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https://www.readbyqxmd.com/read/29605113/disuse-osteopenia-following-leg-fracture-in-postmenopausal-women-implications-for-hip-fracture-risk-and-fracture-liaison-services
#1
S J Hopkins, A D Toms, M Brown, A Appleboam, K M Knapp
INTRODUCTION: Disuse osteopenia is a known consequence of reduced weight-bearing and has been demonstrated at the hip following leg injury but has not been specifically studied in postmenopausal women. METHOD: Bilateral DXA (GE Lunar Prodigy) bone mineral density (BMD) measurements were taken at the neck of femur (NOF), total hip region (TH) and lumbar spine in postmenopausal female groups comprising controls (N = 43), new leg fractures (#<3wks) (N = 9), and participants who had sustained a leg fracture more than one year previously (#>1yr) (N = 24)...
May 2018: Radiography
https://www.readbyqxmd.com/read/29593808/evaluation-of-the-validity-of-treatment-decisions-based-on-surrogate-country-models-before-introduction-of-the-polish-frax-and-recommendations-in-comparison-to-current-practice
#2
Wojciech M Glinkowski, Jerzy Narloch, Bożena Glinkowska, Małgorzata Bandura
Introduction: Patients diagnosed before the Polish FRAX was introduced may require re-evaluation and treatment changes if the diagnosis was established according to a surrogate country FRAX score. The aim of the study was to evaluate the validity of treatment decisions based on the surrogate country model before introduction of the Polish FRAX and to provide recommendations based on the current practice. Material and methods: We evaluated a group of 142 postmenopausal women (70...
March 2018: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29593339/quantitative-proteomic-profiling-of-primary-cancer-associated-fibroblasts-in-oesophageal-adenocarcinoma
#3
Antigoni Manousopoulou, Annette Hayden, Massimiliano Mellone, Diana J Garay-Baquero, Cory H White, Fergus Noble, Monette Lopez, Gareth J Thomas, Timothy J Underwood, Spiros D Garbis
BACKGROUND: Cancer-associated fibroblasts (CAFs) form the major stromal component of the tumour microenvironment (TME). The present study aimed to examine the proteomic profiles of CAFs vs. normal fibroblasts (NOFs) from patients with oesophageal adenocarcinoma to gain insight into their pro-oncogenic phenotype. METHODS: CAFs/NOFs from four patients were sub-cultured and analysed using quantitative proteomics. Differentially expressed proteins (DEPs) were subjected to bioinformatics and compared with published proteomics and transcriptomics  datasets...
March 29, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29520466/leadless-pacemaker-implantation-in-a-pediatric-patient-with-prolonged-sinus-pauses
#4
Shai Tejman-Yarden, Eyal Nof, Roy Beinart, Nadav Ovadia, Yuval Goldshmit, Jonathan Buber, Hagith Yonath, Eitan Keizman, Michael Glikson
Permanent cardiac pacing is the only effective solution for patients with symptomatic bradycardia and heart block. About 10% of patients undergoing implantation of the conventional pacing system develop complications related to the subcutaneous pocket or the leads and in pediatric patients lead problems may rise in up to 30% of the patients. The leadless pacemaker devices were developed in order to minimize some of those complications. We present a case of an 11-year-old patient who presented after the sudden death of his older brother, with recurrent episodes of syncope and documented prolonged sinus pauses...
April 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29498683/a-modified-distributed-bees-algorithm-for-multi-sensor-task-allocation
#5
Itshak Tkach, Aleksandar Jevtić, Shimon Y Nof, Yael Edan
Multi-sensor systems can play an important role in monitoring tasks and detecting targets. However, real-time allocation of heterogeneous sensors to dynamic targets/tasks that are unknown a priori in their locations and priorities is a challenge. This paper presents a Modified Distributed Bees Algorithm (MDBA) that is developed to allocate stationary heterogeneous sensors to upcoming unknown tasks using a decentralized, swarm intelligence approach to minimize the task detection times. Sensors are allocated to tasks based on sensors' performance, tasks' priorities, and the distances of the sensors from the locations where the tasks are being executed...
March 2, 2018: Sensors
https://www.readbyqxmd.com/read/29404625/performance-of-frax-in-clinical-practice-according-to-sex-and-osteoporosis-definitions-the-manitoba-bmd-registry
#6
W D Leslie, S R Majumdar, S N Morin, L M Lix, J T Schousboe, K E Ensrud, H Johansson, E V McCloskey, J A Kanis
Among 62,275 women and 6455 men, FRAX stratified risk for incident major osteoporotic fracture (MOF) and incident hip fracture (HF) without sex interaction. Performance was good in those with osteoporosis regardless of how this was defined. INTRODUCTION: Some studies have reported that FRAX performance differs according to sex and/or osteoporosis definitions. We evaluated whether the performance of FRAX to predict incident MOF and HF in women and men was affected by the presence or absence of osteoporosis defined by World Health Organization (WHO) or National Osteoporosis Foundation (NOF) criteria...
March 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29403315/high-potency-statins-but-not-all-statins-decrease-the-risk-of-new-onset-osteoporotic-fractures-a-nationwide-population-based-longitudinal-cohort-study
#7
Tsung-Kun Lin, Yi-Sheng Liou, Ching-Heng Lin, Pesus Chou, Gwo-Ping Jong
Background: Statins have been linked to new-onset osteoporotic fractures (NOFs), and different statins may alter the risk for the development of NOFs. Aim: In this study, we investigated the association between different statins and the development of NOFs. Patients and methods: This was a longitudinal cohort study performed using data from claim forms submitted to the Taiwan Bureau of National Health Insurance, including case patients with NOFs from January 2004 to December 2013 and non-NOF subjects...
2018: Clinical Epidemiology
https://www.readbyqxmd.com/read/29360827/cxcl1-induces-senescence-of-cancer-associated-fibroblasts-via-autocrine-loops-in-oral-squamous-cell-carcinoma
#8
Eun Kyoung Kim, Sook Moon, Do Kyeong Kim, Xianglan Zhang, Jin Kim
Cancer-associated fibroblasts (CAFs) have emerged as one of the main factors related to cancer progression, however, the conversion mechanism of normal fibroblasts (NOFs) to CAFs has not been well elucidated. The aim of this study was to investigate the underlying mechanism of CAF transformation from NOFs in oral squamous cell carcinoma (OSCC). This study found that NOFs exposed to OSCC cells transformed to senescent cells. The cytokine antibody array showed the highest secretion levels of IL-6 and CXCL1 in NOFs co-cultured with OSCC cells...
2018: PloS One
https://www.readbyqxmd.com/read/29348860/silencing-ror1-and-ror2-inhibits-invasion-and-adhesion-in-an-organotypic-model-of-ovarian-cancer-metastasis
#9
Claire Henry, Neville Hacker, Caroline Ford
OBJECTIVE: Elevated expression of the ROR1 and ROR2 Wnt receptors has been noted in both the tumour and stromal compartments of ovarian cancer patient tissue samples. In vitro studies have suggested these receptors play a role in ovarian cancer metastasis. However, these previous studies have utilised simple 2D in vitro models to investigate cancer cell growth and migration, which does not allow investigation of stromal involvement in Wnt driven metastasis. AIM: To investigate targeting ROR1 and ROR2 using a primary co-culture 3D model of epithelial ovarian cancer dissemination to the omentum...
December 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29328790/hospital-stay-and-blood-transfusion-in-elderly-patients-with-hip-fractures
#10
Efthymios Iliopoulos, Sohail Yousaf, Hazel Watters, Arshad Khaleel
Neck of femur (NOF) fractures in elderly patients are the most frequent condition which an orthopaedic surgeon confronts nowadays. The incidence of these fractures is increasing as the population continues to age. These patients absorb the majority of the resources in the hospitals, as their healthcare demands are increased. This study included all patients who were admitted to our hospital between January and October 2015 following a neck of femur fracture. A total of 336 patients were included (72.3% female)...
December 2017: Journal of Perioperative Practice
https://www.readbyqxmd.com/read/29315354/implications-of-guidelines-for-osteoporosis-and-its-treatment
#11
Stephen Tuck, Elizabeth A Little, Terry J Aspray
The development of clinical guidelines is now a more uniform process, with formalised methods to ensure that recommendations are based on current best available evidence from randomised controlled trials and systematic reviews. Over the past 20 years we have seen a growth in guidelines including those relating to osteoporosis, with recommendations varying between and within countries. Some guidelines are concerned with case finding and primary or secondary prevention, such as those produced by the National Institute for Health and Care Excellence (NICE CG146, TA-160, -161, -464), while others focus on specific conditions or risk factors associated with osteoporosis, such as the menopause, coeliac disease and eating disorder...
January 5, 2018: Age and Ageing
https://www.readbyqxmd.com/read/29224172/evaluation-of-clinical-risk-factors-for-osteoporosis-and-applicability-of-the-frax-tool-in-joinville-city-southern-brazil
#12
Dalisbor Marcelo Weber Silva, Victoria Zeghbi Cochenski Borba, John A Kanis
Clinical risk factors for fracture in Southern Brazil are similar to those used in Fracture Risk Assessment Tool (FRAX®). Age-dependent intervention thresholds had higher accuracy than a fixed cut-off point. INTRODUCTION: Access to bone mineral density testing is wanted for a large part of the Brazilian population. The FRAX® has an option to calculate the risk of fracture without this costly evaluation but relies on the clinical risk factors (CRFs) identified in the source cohorts used to generate FRAX...
December 9, 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/29221185/tgf%C3%AE-1-in-fibroblasts-derived-exosomes-promotes-epithelial-mesenchymal-transition-of-ovarian-cancer-cells
#13
Wenqian Li, Xiaoxue Zhang, Ji Wang, Mengchen Li, Canhui Cao, Jiahong Tan, Ding Ma, Qinglei Gao
Cancer-associated fibroblasts (CAF), a major component of the tumor microenvironment, play an important role in interacting with neoplastic cells to promote ovarian cancer progression. Exosomes are nano-sized vesicles that mediate the cross-talk between different cell types. An increasing number of studies have focused on the fact that tumor cell-derived exosomes influence stromal cells. However, the mechanism by which CAF-derived exosomes modulate cancer cells in ovarian cancer remains obscure. To investigate the role of CAF exosomes in ovarian cancer, we examined the exosomal content of paired primary, metastatic and normal fibroblasts from seven stage IIIC ovarian cancer patients by ELISA...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29217332/revisiting-high-frequency-oscillatory-ventilation-in-vitro-and-in-silico-in-neonatal-conductive-airways
#14
REVIEW
Katrin Bauer, Eliram Nof, Josué Sznitman
BACKGROUND: High frequency oscillatory ventilation is often used for lung support in premature neonates suffering from respiratory distress syndrome. Despite its broad use in neonatal intensive care units, there are to date no accepted protocols for the choice of appropriate ventilation parameter settings. In this context, the underlying mass transport mechanisms are still not fully understood. METHODS: We revisit the question of flow phenomena under conventional mechanical ventilation and high frequency oscillatory ventilation in an anatomically-inspired model of neonatal conductive airways spanning the first few airway generations...
November 28, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/29203402/lamin-a-expression-in-circulating-osteoprogenitors-as-a-potential-biomarker-for-frailty-the-nepean-osteoporosis-and-frailty-nof-study
#15
Ahmed Al Saedi, Piumali Gunawardene, Sandra Bermeo, Sara Vogrin, Derek Boersma, Steven Phu, Lakshman Singh, Pushpa Suriyaarachchi, Gustavo Duque
Lamin A is a protein of the nuclear lamina. Low levels of lamin A expression are associated with osteosarcopenia in mice. In this study, we hypothesized that low lamin A expression is also associated with frailty in humans. We aimed to develop a non-invasive method to quantify lamin A expression in epithelial and circulating osteoprogenitor (COP) cells, and to determine the relationship between lamin A expression and frailty in older individuals. COP cells and buccal swabs were obtained from 66 subjects (median age 74; 60% female; 26 non-frail, 23 pre-frail, and 17 frail) participating at the Nepean Osteoporosis and Frailty (NOF) Study...
February 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29125120/canal-to-diaphysis-ratio-as-a-risk-factor-for-hip-fractures-and-hip-fracture-pattern
#16
Prasad Ellanti, Kunal Mohan, Andrew Moriarity, Niall Hogan, Tom McCarthy
INTRODUCTION: Osteoporosis and related fractures constitute a significant burden on modern healthcare. The standard method of diagnosing osteoporosis with a dual-energy X-ray absorptiometry (DXA) scan is limited by accessibility and expense. The thickness of the cortex of the proximal femur on plain radiographs has been suggested to be a method for indicating osteoporosis and as a risk factor of hip fractures in the elderly. METHODS: A retrospective study was undertaken to assess the usefulness of the canal-diaphysis ratio (CDR) as a risk factor for developing a hip fracture, excluding patients presenting under 50 years old, following high-energy trauma or pathological fractures...
2017: SICOT-J
https://www.readbyqxmd.com/read/29116139/integrated-plasmon-enhanced-raman-scattering-ipers-spectroscopy
#17
Hailong Wang, Haibo Li, Shuping Xu, Bing Zhao, Weiqing Xu
A new strategy named integrated plasmon-enhanced Raman scattering (iPERS) spectroscopy that features a configuration of evanescent field excitation and inverted collection is presented, which well unites the local field enhancement and far field emission, couples localized and propagating surface plasmons, integrates the SERS substrates and Raman spectrometers via a self-designed aplanatic solid immersion lens. A metallic nanoparticle-on-a film (NOF) system was adopted in this configuration because it improves the amplification of the incidence light field in near field by 10 orders of magnitude due to the simultaneous excitation of quadrupolar and dipolar resonance modes...
November 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29081852/the-aetiology-of-the-non-ossifying-fibroma-of-the-distal-femur-and-its-relationship-to-the-surrounding-soft-tissues
#18
A Goldin, D A Muzykewicz, J Dwek, S J Mubarak
PURPOSE: We aim to retrospectively evaluate patients with non-ossifying fibroma (NOF) of the distal femur by radiographs, CT and MRI, and to provide a theory describing the reasoning for the distal femur NOF's location and aetiology. METHODS: Charts of patients with NOFs between 2003 and 2014 were retrospectively reviewed. Inclusion criteria encompassed a diagnosis of NOF of the distal femur by imaging, and histologically, if available. Radiographs, CT and MRI were used to characterise the relationship of the NOF lesions with the surrounding soft tissues...
October 1, 2017: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/28990129/differences-in-lethal-response-between-male-and-female-calanoid-copepods-and-life-cycle-traits-to-cadmium-toxicity
#19
Esther U Kadiene, Capucine Bialais, Baghdad Ouddane, Jiang-Shiou Hwang, Sami Souissi
This study determined the effect of cadmium (Cd) toxicity comparatively on two copepods, Eurytemora affinis (Poppe 1880) from a temperate region (Seine Estuary, France) and Pseudodiaptomus annandalei (Sewell 1919) from a subtropical region (Danshuei Estuary, Taiwan), according to their sex and reproductive stages. In addition, the effect of Cd to their life cycle traits was quantified. In the first experiment, both copepod sexes were exposed to 40, 80, 150, 220, and 360 µg/L of Cd and a control cultured in salinity 15, except that the temperature was 18 °C for E...
November 2017: Ecotoxicology
https://www.readbyqxmd.com/read/28951638/non-parallel-screw-fixation-for-femoral-neck-fractures-in-young-adults
#20
Sherif Galal, Mohamed Nagy
INTRODUCTION: Current literature shows divergence of views regarding screws positioning in femoral neck fractures fixation. The goal of this study is to evaluate the efficiency of divergent screw fixation for fracture neck of femur (NOF). METHODS: The study was conducted at an academic Level 1 Trauma Center. This is a retrospective study conducted from October 2013 to October 2016. The study included 41 patients (33 males, 8 females) suffering from fracture NOF who were fixed using BDSF technique (26 within 24 h...
July 2017: Journal of Clinical Orthopaedics and Trauma
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