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Ureter obstruction

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https://www.readbyqxmd.com/read/28713267/epoxyeicosatrienoic-acid-analog-decreases-renal-fibrosis-by-reducing-epithelial-to-mesenchymal-transition
#1
Melissa Skibba, Md Abdul Hye Khan, Lauren L Kolb, Michael M Yeboah, John R Falck, Radhika Amaradhi, John D Imig
Renal fibrosis, which is a critical pathophysiological event in chronic kidney diseases, is associated with renal epithelial-to-mesenchymal transition (EMT). Epoxyeicosatrienoic acids (EETs) are Cyp epoxygenase arachidonic acid metabolites that demonstrate biological actions that result in kidney protection. Herein, we investigated the ability of 14,15-EET and its synthetic analog, EET-A, to reduce kidney fibrosis induced by unilateral ureter obstruction (UUO). C57/BL6 male mice underwent sham or UUO surgical procedures and were treated with 14,15-EET or EET-A in osmotic pump (i...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28694567/immunohistochemistry-in-ureteropelvic-junction-obstruction-and-its-correlation-to-postoperative-outcome
#2
Anusiri Inugala, Ramesh Kota Reddy, Bhuvaneshwar Nadipalli Rao, Sreenivas P Reddy, Radhika Othuluru, Lavanya Kanniyan, Nagarjuna Kumbha, Srinivas Srirampur
AIM: To investigate the correlation between the status of interstitial cells of Cajal (ICC) in ureteropelvic junction (UPJ) and the resected ureteric margin and the postoperative outcome of Anderson-Hynes pyeloplasty in UPJ obstruction (UPJO) and to compare the ICC in the UPJ and the resected margin of the normal ureter. MATERIALS AND METHODS: An observational study was conducted over a period of 2 years at the Department of Pediatric Surgery at Niloufer Institute of Women and Child Health...
July 2017: Journal of Indian Association of Pediatric Surgeons
https://www.readbyqxmd.com/read/28693464/polypoid-arteriovenous-malformation-of-the-ureter-mimicking-a-fibroepithelial-polyp-a-case-report
#3
C S Ten Donkelaar, A C Houwert, F J W Ten Kate, M T W T Lock
BACKGROUND: Arteriovenous malformations (AVM) of the urinary tract are extremely rare. To the best of our knowledge, only three case of AVM of the ureter have been described in the literature so far. CASE PRESENTATION: We present an additional, fourth case of an AVM of the ureter, clinically presented as asymptomatic haematuria and an obstructive process in the left ureter. Ureteroscopic evaluation revealed a fibroepithelial polypoid-like lesion in the proximal ureter...
July 10, 2017: BMC Urology
https://www.readbyqxmd.com/read/28683770/laparoscopic-ureterocalicostomy-for-ureteropelvic-junction-obstruction-in-a-10-year-old-female-patient-a-case-report
#4
Yoko Nishimura, Kimihiko Moriya, Michiko Nakamura, Takeya Kitta, Yukiko Kanno, Hiroki Chiba, Masafumi Kon, Nobuo Shinohara
BACKGROUND: Ureterocalicostomy is indicated mainly in cases with failed pyeloplasty or with a completely intrarenal pelvis. While there have been several case series reported in adults, laparoscopic ureterocalicostomy in pediatric cases has rarely been reported. We report a case of pure laparoscopic ureterocalicostomy for ureteropelvic junction obstruction in an Asian female child. CASE PRESENTATION: A 10-year-old female patient was referred to our hospital due to right high-grade hydronephrosis and a right renal stone, which was detected due to hematuria...
July 6, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28667820/human-umbilical-cord-derived-mesenchymal-stem-cells-conditioned-medium-attenuate-interstitial-fibrosis-and-stimulate-the-repair-of-tubular-epithelial-cells-in-an-irreversible-model-of-unilateral-ureteral-obstruction
#5
Bo Liu, Feng-Xia Ding, Yang Liu, Geng Xiong, Tao Lin, Da-Wei He, Yuan-Yuan Zhang, De-Ying Zhang, Guang-Hui Wei
AIM: The growing number of patients suffering from chronic renal disease (CKD) is a challenge for the development of innovative therapies. Researchers have studied the therapeutic effects of cell therapy in acute kidney injury (AKI). However, the therapeutical effect of conditional medium (CM) in the CKD models have been rarely reported. Here, we examined the effects of umbilical cord derived-mesenchymal stem cells (hUC-MSCs) CM on renal fibrosis in a rat model of unilateral ureteral obstruction (UUO)...
July 1, 2017: Nephrology
https://www.readbyqxmd.com/read/28655168/bmp4-uses-several-different-effector-pathways-to-regulate-proliferation-and-differentiation-in-the-epithelial-and-mesenchymal-tissue-compartments-of-the-developing-mouse-ureter
#6
Tamrat M Mamo, Anna B Wittern, Marc-Jens Kleppa, Tobias Bohnenpoll, Anna-Carina Weiss, Andreas Kispert
Heterozygous loss of Bmp4 results both in humans and mice in severe malformation of the urinary tract. These defects have at least partially been attributed to loss of expression of Bmp4 in the ureteric mesenchyme, yet the cellular and molecular function of this signal as well as its effector pathways in this tissue have remained incompletely resolved. Here, we show that mice with a conditional deletion of Bmp4 in the ureteric mesenchyme exhibited hydroureter and hydronephrosis at newborn stages due to functional and physical ureter obstruction...
June 26, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28637368/emergency-ureteral-stone-treatment-score-predicts-outcomes-of-ureteroscopic-intervention-in-acute-obstructive-uropathy-secondary-to-urolithiasis
#7
Timothy Y Tran, Natalia Hernandez Bustos, Avinash Kambadakone, Brian Eisner, Gyan Pareek
INTRODUCTION: Immediate ureteroscopic treatment for patients presenting to the emergency room with symptomatic ureterolithiasis is more commonly being utilized. Recent reports demonstrate good efficacy for emergency ureteroscopy (URS); however, preoperative predictors of treatment success have not been described. In this study, we report our multicenter experience with emergency URS and identify predictors of successful treatment. We also describe the Emergency Ureteral Stone Treatment (EUST) score, which integrates these predictors and stratifies patients into those that are likely and unlikely to have successful treatment...
July 19, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28623649/allium-stent-for-the-treatment-of-a-malignant-ureteral-stenosis-a-paradigmatic-case
#8
Marco Oderda, Sergio Lacquaniti, Giuseppe Fasolis
OBJECTIVE: The aim of this study was to present a paradigmatic case where the new-generation Allium URS stent was the optimal choice to treat a malignant ureteral stenosis. METHODS: We describe in detail all the steps of our surgery, performed on a 69-year-old patient with left hydronephrosis caused by lumbo-aortic nodal metastases compressing the ureter. The patient was intolerant to double-J stent due to strong irritative urinary symptoms. Allium URS stent was positioned under fluoroscopy in replacement of pre-existing double-J stent...
June 14, 2017: Urologia
https://www.readbyqxmd.com/read/28621602/resolution-of-nonurine-transudative-pleural-effusion-in-a-cat-after-removal-of-a-hydronephrotic-kidney
#9
Maura E Duffy, Andrew J Specht, Ahmira R Torres, May-Li Cuypers
CASE DESCRIPTION A 3-year-old spayed female Bengal cat was evaluated because of a history of bilateral pleural effusion and hydronephrosis of the right kidney. CLINICAL FINDINGS Cytologic analysis of a pleural fluid sample revealed characteristics of a pure transudate with a high percentage of lymphocytes. Results of fluid biochemical testing were not consistent with urine or chyle. Serum biochemical analysis and echocardiography yielded no evidence of hypoalbuminemia or high hydrostatic pressure secondary to cardiac disease...
July 1, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/28611171/pitfalls-of-the-duplex-system-the-mystery-of-the-missing-stone
#10
Donald Kudakwashe Nyanhongo, Satpal Antil, Syed Nasir
A duplex ureter constitutes about 1% of the renal tract anomalies.A 39-year-old man presented with a 4-week history of left loin pain and microscopic haematuria. Investigation with a non-contrast CT KUB revealed a 6 mm non-obstructing calculus in the left distal ureter.Left ureteroscopy and lithotripsy was planned. However, ureteroscopy failed to identify the calculus. A double J ureteric stent was left in situ and the procedure abandoned in favour of further assessment with a CT urogram. Imaging surprisingly showed a left duplex ureter with the calculus in the non-stented ureter...
June 13, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28597914/computed-tomographic-features-of-urinary-bladder-torsion-in-two-dogs
#11
M Ricciardi, A Campanella, R Martino
Urinary bladder torsion is rare in dogs. It is characterised by rotation of the organ along its longitudinal axis and is potentially life-threatening because of urinary flow obstruction with subsequent urine retention, hydroureter, hydronephrosis and azotaemia. This report describes the computed tomographic features of urinary bladder torsion in two dogs. In both cases, the hallmark indicative of torsion was the "whirl sign," originating from the twisted pelvic urethra and urinary bladder neck encircling the ureters, blood vessels and bladder ligaments in a characteristic spiral pattern...
June 9, 2017: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/28595936/the-peak-site-of-stone-distribution-in-the-upper-ureter-is-unlikely-the-ureteropelvic-junction-ct-analysis-of-stone-lodging-site-with-respect-to-a-newly-identified-area-of-constriction
#12
Minobu Kamo, Taiki Nozaki, Jay Starkey, Saya Horiuchi, Natsuka Muraishi, Kazunori Hattori, Keiichi Akita
OBJECTIVES: To investigate the relationship between the upper urinary stone distribution and the "crossing point"; an area of relative fixation within the upper ureter at approximately the level where the ureter crosses the gonadal vein. METHODS: We reviewed 298 consecutive patients presenting with acute renal colic, identified upper ureteral stones in computed tomography. For stones located at "renal pelvis and upper ureter", we measured the vertebral level of each renal pelvis, crossing point, and stone...
June 5, 2017: Urology
https://www.readbyqxmd.com/read/28595935/predictors-of-renal-functional-improvement-after-pyeloplasty-in-ureteropelvic-junction-obstruction-clinical-value-of-visually-assessed-renal-tissue-tracer-transit-in-99m-tc-mercaptoacetyltriglycine-renography
#13
Sang Hoon Song, Sahyun Park, Sun Young Chae, Dae Hyuk Moon, Sungchan Park, Kun Suk Kim
OBJECTIVE: To determine the clinical value of visually assessed renal tissue transit time (TTT) in (99m)Tc-mercaptoacetyltriglycine ((99m)Tc-MAG3) renography for patients undergoing pyeloplasty. MATERIALS AND METHODS: Medical records of 164 patients who underwent dismembered pyeloplasty were retrospectively reviewed. Baseline and postoperative renal ultrasonography and (99m)Tc-MAG3 renography were performed. Two urologists blinded to clinical data evaluated the renography and classified TTT as timely or delayed based on visualization of the tracer in the kidney pelvis between 2 and 10 minutes...
July 3, 2017: Urology
https://www.readbyqxmd.com/read/28585302/rictor-mtorc2-promotes-macrophage-activation-and-kidney-fibrosis
#14
Jiafa Ren, Jianzhong Li, Ye Feng, Bingyan Shu, Yuan Gui, Wei Wei, Weichun He, Junwei Yang, Chunsun Dai
Mammalian target of rapamycin (mTOR) signaling controls many essential cellular functions. However, the role for Rictor/mTORC2 in regulating macrophage activation and kidney fibrosis remains largely unknown. We report here that Rictor/mTORC2 was activated in macrophages from the fibrotic kidneys of mice. Ablation of Rictor in macrophages diminished kidney fibrosis, inflammatory cell accumulation, macrophage proliferation and polarization after unilateral ureter obstruction (UUO) or ischemia/reperfusion injury (IRI)...
June 6, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/28580040/pseudo-prune-belly-syndrome-diagnosis-revealed-by-imaging-a-case-report-and-brief-review
#15
Hemal Grover, Sanjay Sethi, Jatin Garg, Amrit Pal Ahluwalia
BACKGROUND: Prune Belly Syndrome (PBS) is a rare entity, usually found in male neonates. It comprises complex urinary tract anomalies, bilateral undescended testis and absence of anterior abdominal wall muscles. Patients with unilateral abdominal wall deficiency, unilateral undescended testis and female neonates with abdominal wall laxity are classified as Pseudo Prune Belly syndrome (PPBS). Reports on PPBS do not highlight the radiological and imaging characteristics of this syndrome and the current literature on the role of newer imaging modalities, such as Magnetic Resonance Imaging (MRI), remains relatively sparse...
2017: Polish Journal of Radiology
https://www.readbyqxmd.com/read/28570883/terminal-ileostomy-and-on-table-enteroscopy-a-case-report-describing-a-novel-approach-for-retrieval-of-foreign-bodies-in-the-difficult-abdomen
#16
Shadi Al-Bahri, Esther Cha, Gregory Burgoyne
INTRODUCTION: With any abdominal surgery in a difficult abdomen, the procedure is filled with potential hazards. In addition to a prolonged operative time, there is a risk of enterotomy or damage to blood vessels and ureters. An irradiated pelvis increases this risk and may cause additional morbidity such as delayed healing. An impacted foreign body can also be a challenging problem to deal with alone but when combined with a difficult abdomen can make the problem impossible. PRESENTATION OF CASE: A 67 year-old male presented with a small bowel obstruction secondary to a foreign body impacted in the distal...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28566415/a-rare-cause-of-anuria-in-a-case-of-pre-b-acute-lymphoblastic-leukaemia
#17
Siddhesh Arun Kalantri, Rahul Singla, Malay Kumar Bera, Maitreyee Bhattyacharyya
Renal failure in cases of acute lymphoblastic leukaemia during induction is mainly because of sepsis and tumour lysis syndrome. This 18-year-old man had sudden onset anuria with increase in creatine. At this time, patient did not have any overt signs or laboratory features suggestive of sepsis. Imaging studies documented bilateral hydronephrosis. Ureteroscopy was done, and it showed presence of soft tissue mass obstructing the ureter. On the the left side, it was noted in its middle part and on the right, at the ureteropelvic junction...
May 31, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28537409/-ureterointestinal-anastomosis-in-urinary-diversion-current-opinion
#18
J Doležel
Uretero-intestinal anastomosis (UIA) is one of the most critical points for the occurrence of severe complications of intestinal urinary diversion. Perfection of the current techniques and development of new UIA methods are motivated by the effort to reduce both early and late post-surgical complications. The necessity of using antireflux UIA, especially with an orthotopic neobladder, is controversial: according to some authors, antireflux UIA of any type generally increases, in comparison with reflux UIA, the risk of obstruction that endangers renal function more than the urine reflux itself...
2017: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
https://www.readbyqxmd.com/read/28536083/preoperatively-dilated-ureters-are-a-specific-risk-factor-for-the-development-of-ureteroenteric-strictures-after-open-radical-cystectomy-and-ileal-neobladder
#19
Richard E Hautmann, Robert de Petriconi, Andreas Kahlmeyer, Melanie Enders, Bjoern Volkmer
PURPOSE: To evaluate preoperative ureteral obstruction as risk factor for the development of benign UEAS in patients undergoing open RC and INB diversion. MATERIAL AND METHODS: 953 patients with bilateral ileoureterostomy, performed between 01/86 and 03/09, form the study population with a non-refluxing (Le Duc) technique in 357 and a refluxing (Wallace type) technique in 596 consecutive patients. We defined UEAS as need for specific therapy (e.g. stenting, dilatation, reimplantation) or proven loss of renal function...
May 20, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28508426/the-role-of-transvaginal-ultrasound-in-the-evaluation-of-ureteral-involvement-in-deep-endometriosis
#20
P Carfagna, C De Cicco Nardone, A De Cicco Nardone, A C Testa, G Scambia, R Marana, F De Cicco Nardone
OBJECTIVE: To assess whether routine visualization of the pelvic ureter during transvaginal ultrasonography should be performed in all patients with deep endometriosis candidate to surgery, in order to identify a potential silent ureteral involvement by the disease. METHODS: This was a prospective study of 200 consecutive patients undergoing surgery for deep endometriosis, evaluated between January 2012 and December 2014 at a tertiary endometriosis center at the Department of Obstetrics and Gynecology, Fondazione Policlinico Universitario A...
May 15, 2017: Ultrasound in Obstetrics & Gynecology
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