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Newtonian fluid blood

Mohammad Yaghoub Abdollahzadeh Jamalabadi, Mohammadreza Daqiqshirazi, Hossein Nasiri, Mohammad Reza Safaei, Truong Khang Nguyen
We present a numerical investigation of tapered arteries that addresses the transient simulation of non-Newtonian bio-magnetic fluid dynamics (BFD) of blood through a stenosis artery in the presence of a transverse magnetic field. The current model is consistent with ferro-hydrodynamic (FHD) and magneto-hydrodynamic (MHD) principles. In the present work, blood in small arteries is analyzed using the Carreau-Yasuda model. The arterial wall is assumed to be fixed with cosine geometry for the stenosis. A parametric study was conducted to reveal the effects of the stenosis intensity and the Hartman number on a wide range of flow parameters, such as the flow velocity, temperature, and wall shear stress...
2018: PloS One
Johanna Clauser, Marius S Knieps, Martin Büsen, Andreas Ding, Thomas Schmitz-Rode, Ulrich Steinseifer, Jutta Arens, Giorgio Cattaneo
Particle image velocimetry (PIV) is a commonly used method for in vitro investigation of fluid dynamics in biomedical devices, such as flow diverters for intracranial aneurysm treatment. Since it is limited to transparent blood substituting fluids like water-glycerol mixture, the influence of coagulation and platelet aggregation is neglected. We aimed at the development and the application of a modified platelet rich plasma as a new PIV fluid with blood-like rheological and coagulation properties. In standardized intracranial aneurysm silicone models, the effect of this new PIV plasma on the fluid dynamics before and after flow diverter implantation was evaluated and compared with water-glycerol measurements...
February 27, 2018: Annals of Biomedical Engineering
Dongyang Cai, Qiaolian Yi, Chaohua Shen, Ying Lan, Gerald Urban, Wenbin Du
The full potential of microfluidic techniques as rapid and accurate methods for the detection of disease-causing agents and foodborne pathogens is critically limited by the complex sample preparation process, which commonly comprises the enrichment of bacterial cells to detectable levels. In this manuscript, we describe a microfluidic device which integrates H-filter desalination with positive dielectrophoresis (pDEP) for direct enrichment of bacterial cells from physiological samples of high conductivity and viscosity, such as cow's milk and whole human blood...
January 2018: Biomicrofluidics
Qinlong Ren
Efficient pumping of blood flow in a microfluidic device is essential for rapid detection of bacterial bloodstream infections (BSI) using alternating current (AC) electrokinetics. Compared with AC electroosmosis (ACEO) phenomenon, the advantage of AC electrothermal (ACET) mechanism is its capability of pumping biofluids with high electrical conductivities at a relatively high AC voltage frequency. In the current work, the microfluidic pumping of non-Newtonian blood flow using ACET forces is investigated in detail by modeling its multi-physics process with hybrid boundary element method (BEM) and immersed boundary-lattice Boltzmann method (IB-LBM)...
February 10, 2018: Electrophoresis
Eleonora Tubaldi, Michael Paidoussis, Marco Amabili
This study addresses the dynamic response to pulsatile physiological blood flow and pressure of a woven Dacron graft currently used in thoracic aortic surgery. The model of the prosthesis assumes a cylindrical orthotropic shell described by means of nonlinear Novozhilov shell theory. The blood flow is modeled as Newtonian pulsatile flow, and unsteady viscous effects are included. Coupled fluid-structure Lagrange equations for open systems with wave propagation subject to pulsatile flow are applied. Physiological waveforms of blood pressure and velocity are approximated with the first eight harmonics of the corresponding Fourier series...
February 8, 2018: Journal of Biomechanical Engineering
Vikas Thondapu, Erhan Tenekecioglu, Eric K W Poon, Carlos Collet, Ryo Torii, Christos V Bourantas, Cheng Chin, Yohei Sotomi, Hans Jonker, Jouke Dijkstra, Eve Revalor, Frank Gijsen, Yoshinobu Onuma, Andrew Ooi, Peter Barlis, Patrick W Serruys
Aims: As a sine qua non for arterial wall physiology, local hemodynamic forces such as endothelial shear stress (ESS) may influence long-term vessel changes as bioabsorbable scaffolds dissolve. The aim of this study was to perform serial computational fluid dynamic (CFD) simulations to examine immediate and long-term haemodynamic and vascular changes following bioresorbable scaffold placement. Methods and results: Coronary arterial models with long-term serial assessment (baseline and 5 years) were reconstructed through fusion of intravascular optical coherence tomography and angiography...
February 2, 2018: European Heart Journal
Dharmendra Tripathi, Ashu Yadav, O Anwar Bég, Rakesh Kumar
An analytical study of microvascular non-Newtonian blood flow is investigated in presence of electro-osmosis phenomenon. Blood is considered as a Bingham rheological aqueous ionic solutions. An externally applied static axial electrical field is imposed on the system. The Poisson-Boltzmann equation for electric potential distribution is implemented to accommodate the electrical double layer in the microvascular. With long wavelength, lubrication and Debye-Hückel approximations, the boundary value problem is rendered non-dimensional...
January 3, 2018: Microvascular Research
A Abbas Nejad, Z Talebi, D Cheraghali, A Shahbani-Zahiri, M Norouzi
BACKGROUND AND OBJECTIVE: In this study, the interaction of pulsatile blood flow with the viscoelastic walls of the axisymmetric artery is numerically investigated for different severities of stenosis. The geometry of artery is modeled by an axisymmetric cylindrical tube with a symmetric stenosis in a two-dimensional case. The effects of stenosis severity on the axial velocity profile, pressure distribution, streamlines, wall shear stress, and wall radial displacement for the viscoelastic artery are also compared to the elastics artery...
February 2018: Computer Methods and Programs in Biomedicine
Joshua A Gregory, Cecilia Kemi, Jie Ji, Jakob Karén, Ingrid Delin, Per Gerde, Michael P Pieper, Mikael Adner, Kjell Larsson
INTRODUCTION: Acute exposure to organic dust (OD) in pig barns induces intense airway inflammation with neutrophilia and hyperresponsiveness. This reaction is likely associated with increased cholinergic activity. Therefore, the involvement of cholinergic mechanisms in the reaction to acute exposure of OD was investigated in mice using the long-acting muscarinic antagonist tiotropium. METHODS: BALB/c mice received tiotropium (2-200 ng) intranasally on day 1 of the study...
December 13, 2017: Pulmonary Pharmacology & Therapeutics
Thijs C de Goede, Nick Laan, Karla de Bruin, Daniel Bonn
We investigate the impact velocity beyond which the ejection of smaller droplets from the main droplet (splashing) occurs for droplets of different liquids impacting different smooth surfaces. We examine its dependence on the surface wetting properties and droplet surface tension. We show that the splashing velocity is independent of the wetting properties of the surface, but increases roughly linearly with increasing surface tension of the liquid. A preexisting splashing model and simplification are considered that predicts the splashing velocity by incorporating the air viscosity...
December 13, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
Abas Ramiar, Morsal Momenti Larimi, Ali Akbar Ranjbar
PURPOSE: Hemodynamic factors, such as Wall Shear Stress (WSS), play a substantial role in arterial diseases. In the larger arteries, such as the carotid artery, interaction between the vessel wall and blood flow affects the distribution of hemodynamic factors. The fluid is considered to be non-Newtonian, whose flow is governed by the equation of a second-grade viscoelastic fluid and the effects of viscoelastic on blood flow in carotid artery is investigated. METHODS: Pulsatile flow studies were carried out in a 3D model of carotid artery...
2017: Acta of Bioengineering and Biomechanics
R Jayendiran, B M Nour, A Ruimi
Aortic dissection (AD) is a serious medical condition characterized by a tear in the intima, the inner layer of the aortic walls. In such occurrence, blood is being diverted to the media (middle) layer and may result in patient death if not quickly attended. In the case where the diseased portion of the aorta needs to be replaced, one common surgical technique is to use a graft made of Dacron, a synthetic fabric. We investigate the response of a composite human aortic segment-Dacron graft structure subjected to blood flow using the three-dimensional fluid-structure-interaction (FSI) capability in Abaqus...
February 2018: Journal of the Mechanical Behavior of Biomedical Materials
M P Thon, A Hemmler, A Glinzer, M Mayr, M Wildgruber, A Zernecke-Madsen, M W Gee
This work is devoted to the development of a mathematical model of the early stages of atherosclerosis incorporating processes of all time scales of the disease and to show their interactions. The cardiovascular mechanics is modeled by a fluid-structure interaction approach coupling a non-Newtonian fluid to a hyperelastic solid undergoing anisotropic growth and a change of its constitutive equation. Additionally, the transport of low-density lipoproteins and its penetration through the endothelium is considered by a coupled set of advection-diffusion-reaction equations...
November 20, 2017: Biomechanics and Modeling in Mechanobiology
Marcello Iasiello, Kambiz Vafai, Assunta Andreozzi, Nicola Bianco
The geometry of the arteries at or near arterial bifurcation influences the blood flow field, which is an important factor affecting arteriogenesis. The blood can act sometimes as a non-Newtonian fluid. However, many studies have argued that for large and medium arteries, the blood flow can be considered to be Newtonian. In this work a comprehensive investigation of non-Newtonian effects on the blood fluid dynamic behavior in an aorta-iliac bifurcation is presented. The aorta-iliac geometry is reconstructed with references to the values reported in Shah et al...
October 13, 2017: Journal of Biomechanics
Fiona R Smith, Naomi C Buntsma, David Brutin
Bloodstain pattern analysis (BPA) is used on a daily basis as evidence in crime scene reconstruction. However, though the impact behavior of complex fluid droplets have been extensively studied, important questions still remain. We investigate the influence of surface roughness and wettability on the splashing limit of droplets of blood, a non-Newtonian colloidal fluid. Droplets of blood perpendicularly impacting different surfaces at different velocities were recorded with a high-speed camera. The recordings were analyzed as well as the surfaces characteristics in order to find an empirical solution because we found that roughness plays a major role in the threshold of the splashing/nonsplashing behavior of blood compared to the wettability...
November 7, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
Shahrokh Rahmani, Amin Jarrahi, Mahdi Navidbakhsh, Mansour Alizadeh
One of the important parts of the cardiac system is aorta which is the fundamental channel and supply of oxygenated blood in the body. Diseases of the aorta represent critical cardiovascular bleakness and mortality around the world. This study aims at investigation of hemodynamic parameters in a two-dimensional axisymmetric model of three-layer grafted aorta using fluid-structure interaction (FSI). It assumes that a damaged part of aorta, which may happen as a result of some diseases like aneurysm, dissection and post-stenotic dilatation, is replaced with a biomaterial graft...
October 27, 2017: Journal of Medical Engineering & Technology
Julien Aniort, Laurent Chupin, Nicolae Cîndea
Calcium has two important roles in haemodialysis. It participates in the activation of blood coagulation and calcium intakes have a major impact on patient mineral and bone metabolism. The aim of this article is to propose a mathematical model for calcium ions concentration in a dialyzer during haemodialysis using a citrate dialysate. The model is composed of two elements. The first describes the flows of blood and dialysate in a dialyzer fibre. It was obtained by asymptotic analysis and takes into account the anisotropy of the fibres forming a dialyzer...
October 20, 2017: Mathematical Medicine and Biology: a Journal of the IMA
Justin K S Tan, Sung-Yong Park, Hwa Liang Leo, Sangho Kim
White blood cells (WBCs) are the only cellular constituent containing genetic materials, and, hence, are candidate biomarkers for a host of diseases. However, conventional methods for WBC separation tend to have low sample purity and separation efficiency, which will have adverse implications on downstream polymerase chain reaction (PCR) analyses. In this study, we introduce a two-stage microfluidic device which harnesses the elastic property of a non-Newtonian fluid for size-based separation of WBCs from whole blood...
October 5, 2017: IEEE Transactions on Biomedical Circuits and Systems
G Ahmed, O Arjmandi Tash, J Cook, A Trybala, V Starov
Wetting and spreading kinetics of biological fluids has gained a substantial interest recently. The importance of these fluids in our lives has driven the pace of publications. Globally scientists have ever growing interest in understanding wetting phenomena due to its vast applications in biological fluids. It is impractical to review extremely large number of publications in the field of kinetics of complex biological fluids and cosmetic solutions on diverse surfaces. Therefore, biological and cosmetic applications of wetting and spreading dynamics are considered in the following areas: (i) Spreading of Newtonian liquids in the case of non-porous and porous substrates...
August 18, 2017: Advances in Colloid and Interface Science
Hamed Rezaie, Ali Ashrafizadeh, Afsaneh Mojra
Circle of Willis (CoW) is one of the most important cerebral arteries in the human body and various attempts have been made to study the hemodynamic of blood flow in this vital part of the brain. In the present study, blood flow in a patient specific CoW is numerically modeled to predict disease-prone regions of the CoW. Medical images and computer aided design software are used to construct a realistic three-dimensional model of the CoW for this particular case. The arteries are considered as elastic conduits and the interactions between arterial walls and the blood flow are taken into account...
December 2017: Cardiovascular Engineering and Technology
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