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Newtonian fluid blood

Johannes V Soulis, Dimitrios K Fytanidis, Olga P Lampri, George D Giannoglou
BACKGROUND: The temporal variation of the hemodynamic mechanical parameters during cardiac pulse wave is considered as an important atherogenic factor. Applying non-Newtonian blood molecular viscosity simulation is crucial for hemodynamic analysis. Understanding low density lipoprotein (LDL) distribution in relation to flow parameters will possibly spot the prone to atherosclerosis aorta regions. METHODS: The biomechanical parameters tested were averaged wall shear stress (AWSS), oscillatory shear index (OSI) and relative residence time (RRT) in relation to the LDL concentration...
April 2016: Cardiology Research
M M Bhatti, A Zeeshan, R Ellahi
In this article, heat transfer analysis on clot blood model of the particle-fluid suspension through a non-uniform annulus has been investigated. The blood propagating along the whole length of the annulus was induced by peristaltic motion. The effects of variable viscosity and slip condition are also taken into account. The governing flow problem is modeled using lubrication approach by taking the assumption of long wavelength and creeping flow regime. The resulting equation for fluid phase and particle phase is solved analytically and closed form solutions are obtained...
December 2016: Computer Methods and Programs in Biomedicine
M Y Abdollahzadeh Jamalabadi, Amin Ali Akbari Bidokhti, Hamid Khak Rah, Siavash Vaezi, Payam Hooshmand
Current paper is focused on transient modeling of blood flow through a tapered stenosed arteries surrounded a by solenoid under the presence of heat transfer. The oxygenated and deoxygenated blood are considered here by the Newtonian and Non-Newtonian fluid (power law and Carreau-Yasuda) models. The governing equations of bio magnetic fluid flow for an incompressible, laminar, homogeneous, non-Newtonian are solved by finite volume method with SIMPLE algorithm for structured grid. Both magnetization and electric current source terms are well thought-out in momentum and energy equations...
2016: PloS One
M M Bhatti, A Zeeshan, R Ellahi
In this article, simultaneous effects of coagulation (blood clot) and variable magnetic field on peristaltically induced motion of non-Newtonian Jeffrey nanofluid containing gyrotactic microorganism through an annulus have been studied. The effects of an endoscope also taken into consideration in our study as a special case. The governing flow problem is simplified by taking the approximation of long wavelength and creeping flow regime. The resulting highly coupled differential equations are solved analytically with the help of perturbation method and series solution have been presented up to second order approximation...
November 29, 2016: Microvascular Research
Oualid Kafi, Nader El Khatib, Jorge Tiago, Adelia Sequeira
The inflammatory process of atherosclerosis leads to the formation of an atheromatous plaque in the intima of the blood vessel. The plaque rupture may result from the interaction between the blood and the plaque. In each cardiac cycle, blood interacts with the vessel, considered as a compliant nonlinear hyperelastic. A three dimensional idealized fluid-structure interaction (FSI) model is constructed to perform the blood-plaque and blood-vessel wall interaction studies. An absorbing boundary condition (BC) is imposed directly on the outflow in order to cope with the spurious reflexions due to the truncation of the computational domain...
February 1, 2017: Mathematical Biosciences and Engineering: MBE
Theresa Stotesbury, Michael C Taylor, Mark C Jermy
The spreading dynamics of blood dripping onto hard surfaces is compared to two spreading models. Samples of human blood, porcine blood, and Millipore(®) water were dripped onto cardboard, foamcore, and glass surfaces in low velocity passive drip simulations. Final stain diameter, the total number of spines and scallops, and angle of impact were measured and analyzed. Spreading is best predicted by applying the concept of effective viscosity to the Scheller and Bousfield (R(2)  = 0.91) and Roisman (R(2)  = 0...
January 2017: Journal of Forensic Sciences
Jinkee Lee, Sunho Kim, Sung-Min Kim, Ryungeun Song, Hyun Kyu Kim, Jang Sang Park, Sun Cheol Park
INTRODUCTION: A radiocephalic arteriovenous fistula (AVF) is the best choice for achieving vascular access (VA) for hemodialysis, but this AVF has high rates of early failure due to juxta-anastomotic stenosis, making it impossible to use for dialysis. Low hemodynamic shear stress contributes to the pathophysiology of VA failure due to secondary thrombosis, stenosis, and re-occlusion after percutaneous intervention. METHODS: We used a computational fluid dynamics (CFDs) approach to evaluate the shear stress distribution and minimize its effects under various conditions including changes in the anastomosis angle...
November 2, 2016: Journal of Vascular Access
Wei-Tao Wu, Andrea Blue Martin, Alberto Gandini, Nadine Aubry, Mehrdad Massoudi, James F Antaki
This study is motivated by the development of a blood cell filtration device for removal of malaria-infected, parasitized red blood cells (pRBCs). The blood was modeled as a multi-component fluid using the computational fluid dynamics discrete element method (CFD-DEM), wherein plasma was treated as a Newtonian fluid and the red blood cells (RBCs) were modeled as soft-sphere solid particles which move under the influence of drag, collisions with other RBCs, and a magnetic force. The CFD-DEM model was first validated by a comparison with experimental data from Han et al...
2016: Microfluidics and Nanofluidics
L L Xiao, Y Liu, S Chen, B M Fu
Adhesion of circulating tumor cells (CTCs) to the microvessel wall largely depends on the blood hydrodynamic conditions, one of which is the blood viscosity. Since blood is a non-Newtonian fluid, whose viscosity increases with hematocrit, in the microvessels at low shear rate. In this study, the effects of hematocrit, vessel size, flow rate and red blood cell (RBC) aggregation on adhesion of a CTC in the microvessels were numerically investigated using dissipative particle dynamics. The membrane of cells was represented by a spring-based network connected by elastic springs to characterize its deformation...
October 13, 2016: Biomechanics and Modeling in Mechanobiology
Roman Štukelj, Karin Schara, Apolonija Bedina-Zavec, Vid Šuštar, Manca Pajnič, Ljubiša Pađen, Judita Lea Krek, Veronika Kralj-Iglič, Anita Mrvar-Brečko, Rado Janša
During harvesting of nanovesicles (NVs) from blood, blood cells and other particles in blood are exposed to mechanical forces which may cause activation of platelets, changes of membrane properties, cell deformation and shedding of membrane fragments. We report on the effect of shear forces imposed upon blood samples during the harvesting process, on the concentration of membrane nanovesicles in isolates from blood. Mathematical models of blood flow through the needle during sampling with vacuumtubes and with free flow were constructed, starting from the Navier-Stokes formalism...
October 11, 2016: European Journal of Pharmaceutical Sciences
Chubin Ou, Wei Huang, Matthew Ming-Fai Yuen, Yi Qian
Hemodynamics has been recognized as an important factor in the development, growth, and rupture of cerebral aneurysms, and investigated by computational fluid dynamics techniques using a single phase approach. However, flow-dependent cell transport and interactions are usually ignored in single phase models, in which blood is usually treated as a single phase Newtonian fluid. For getting better insight into the underlying pathology of intracranial aneurysm, cell transport and interactions should be covered in hemodynamic studies...
October 3, 2016: Journal of Biomechanics
M O Khan, D A Steinman, K Valen-Sendstad
Computational fluid dynamics (CFD) shows promise for informing treatment planning and rupture risk assessment for intracranial aneurysms. Much attention has been paid to the impact on predicted hemodynamics of various modelling assumptions and uncertainties, including the need for modelling the non-Newtonian, shear-thinning rheology of blood, with equivocal results. Our study clarifies this issue by contextualizing the impact of rheology model against the recently demonstrated impact of CFD solution strategy on the prediction of aneurysm flow instabilities...
October 1, 2016: International Journal for Numerical Methods in Biomedical Engineering
Akbar Zaman, Nasir Ali, M Sajid, Tasawar Hayat
The pulsatile flow of blood in a catheterized blood vessel is analyzed. The flow of blood in vessel is modeled as the flow of two immiscible fluids. The fluid in the core region is characterized as a non-Newtonian viscoelastic fluid satisfying the constitutive equation of an Oldroyd-B fluid. The fluid in the peripheral region is treated as a Newtonian fluid. The catheter inside the vessel is modeled as a rigid tube of very small radius. The resulting differential system for velocity in each region is computed numerically by finite-difference scheme and analytically by Laplace transform...
2016: PloS One
Bruno Guerciotti, Christian Vergara, Sonia Ippolito, Alfio Quarteroni, Carlo Antona, Roberto Scrofani
Coronary artery disease, caused by the buildup of atherosclerotic plaques in the coronary vessel wall, is one of the leading causes of death in the world. For high-risk patients, coronary artery bypass graft is the preferred treatment. Despite overall excellent patency rates, bypasses may fail due to restenosis. In this context, the purpose of this work was to perform a parametric computational study of the fluid dynamics in patient-specific geometries with the aim of investigating a possible relationship between coronary stenosis degree and risk of graft failure...
February 2017: Biomechanics and Modeling in Mechanobiology
Takashi Suzuki, Hiroyuki Takao, Takamasa Suzuki, Tomoaki Suzuki, Shunsuke Masuda, Chihebeddine Dahmani, Mitsuyoshi Watanabe, Hiroya Mamori, Toshihiro Ishibashi, Hideki Yamamoto, Makoto Yamamoto, Yuichi Murayama
BACKGROUND: In most simulations of intracranial aneurysm hemodynamics, blood is assumed to be a Newtonian fluid. However, it is a non-Newtonian fluid, and its viscosity profile differs among individuals. Therefore, the common viscosity assumption may not be valid for all patients. OBJECTIVE: This study aims to test the suitability of the common viscosity assumption. METHODS: Blood viscosity datasets were obtained from two healthy volunteers...
July 29, 2016: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
Hiroyuki Tsukui, Manabu Shinke, Young Kwang Park, Kenji Yamazaki
Distal anastomosis technique affects graft patency and long-term outcomes in coronary artery bypass grafting, however, there is no standard for the appropriate length of distal anastomosis. The purpose of this study is to evaluate whether longer distal anastomosis provides higher quality of distal anastomosis and better hemodynamic patterns. Off pump CABG training simulator, YOUCAN (EBM Corporation, Japan), was used for distal anastomosis model. Two lengths of distal anastomosis model (10 versus 4 mm) were prepared by end-to-side anastomosis technique...
August 2, 2016: Heart and Vessels
Alireza Sharifi, Mohammad Charjouei Moghadam
INTRODUCTION: Buerger's disease is an occlusive arterial disease that occurs mainly in medium and small vessels. This disease is associated with Tobacco usage. The existence of corkscrew collateral is one of the established characteristics of the Buerger's disease. METHODS: In this study, the computational fluid dynamics (CFD) simulation of blood flow within the corkscrew artery of the Buerger's disease is conducted. The geometry of the artery is constructed based on the actual corkscrew artery of a patient diagnosed with the Buerger's disease...
2016: BioImpacts: BI
M A El Kot, W Abbas
This study is concerned with the surgical technique for the injection of a catheter through arteries with overlapping stenosis in the presence of externally applied magnetic field and Hall currents influences. The nature of blood is analyzed mathematically by considering it as a micropolar fluid. The analysis is carried out for an artery with a mild stenosis. The governing equations with the corresponding boundary conditions solved numerically using Crank-Nicolson implicit finite difference scheme. The numerical technique give excellent agreement for axial velocity of the fluid, the circumferential microrotation, the wall shear stress distribution and the contour plots of stream lines...
January 2017: Computer Methods in Biomechanics and Biomedical Engineering
Dhananjay Radhakrishnan Subramaniam, David J Gee
Particle suspensions are common to biological fluid flows; for example, flow of red- and white-blood cells, and platelets. In medical technology, current and proposed methods for drug delivery use membrane-bounded liquid capsules for transport via the microcirculation. In this paper, we consider a 3D linear elastic particle inserted into a Newtonian fluid and investigate the time-dependent deformation using a numerical simulation. Specifically, a boundary element technique is used to investigate the motion and deformation of initially spherical or spheroidal particles in bounded linear shear flow...
September 2016: Journal of the Mechanical Behavior of Biomedical Materials
Sophie Roman, Adlan Merlo, Paul Duru, Frédéric Risso, Sylvie Lorthois
Despite the development of microfluidics, experimental challenges are considerable for achieving a quantitative study of phase separation, i.e., the non-proportional distribution of Red Blood Cells (RBCs) and suspending fluid, in microfluidic bifurcations with channels smaller than 20 μm. Yet, a basic understanding of phase separation in such small vessels is needed for understanding the coupling between microvascular network architecture and dynamics at larger scale. Here, we present the experimental methodologies and measurement techniques developed for that purpose for RBC concentrations (tube hematocrits) ranging between 2% and 20%...
May 2016: Biomicrofluidics
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