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Ema Mataca, Mario Migaldi, Anna M Cesinaro
BACKGROUND: Equivocal pigmented lesions of the head are usually biopsied to avoid inappropriate treatment. Clinical approach has evolved from simple visual examination to sophisticated techniques for selecting the biopsy sites. OBJECTIVE: This study aimed to retrospectively evaluate the efficiency of dermoscopy (DE) and reflectance confocal microscopy (RCM) in sampling a histopathologically representative focus of lentigo maligna/lentigo maligna melanoma. METHODS: Punch biopsies and surgical excisions of 72 patients, 37 men and 35 women (median age 70...
June 15, 2018: American Journal of Dermatopathology
Ayman Abdel-Aziz Swelum, Islam M Saadeldin, Abdullah Moumen, Hani Ba-Awadh, Abdullah N Alowaimer
The reproductive efficiency of camels can be improved using artificial insemination and embryo transfer programs that require a dependable method for synchronization of follicular waves. This study aimed to evaluate the efficacy of a progesterone-releasing intravaginal device (PRIDΔ® ) to induce synchronization for the follicular wave in Camelus dromedarius during the rutting season, by ovarian monitoring, assessing sexual receptivity and fertility, and quantifying progesterone (P4) and estradiol (E2) concentrations...
June 18, 2018: Theriogenology
Maria Papageorgiou, Daniel Martin, Hannah Colgan, Simon Cooper, Julie P Greeves, Jonathan C Y Tang, William D Fraser, Kirsty J Elliott-Sale, Craig Sale
PURPOSE: We aimed to explore the effects of low energy availability (EA)[15 kcal·kg lean body mass (LBM)-1 ·d-1 ] achieved by diet or exercise on bone turnover markers in active, eumenorrheic women. METHODS: By using a crossover design, ten eumenorrheic women (VO2 peak : 48.1 ± 3.3 ml·kg-1 ·min-1 ) completed all three, 3-day conditions in a randomised order: controlled EA (CON; 45 kcal·kgLBM-1 ·d-1 ), low EA through dietary energy restriction (D-RES; 15 kcal·kgLBM-1 ·d-1 ) and low EA through increasing exercise energy expenditure (E-RES; 15 kcal·kgLBM-1 ·d-1 ), during the follicular phase of three menstrual cycles...
June 19, 2018: Bone
Zhipeng Liu, Silin Huang, Zhengyu Chen, Xinying Wang
Lymphoid follicular proctitis (LFP) is an uncommon inflammatory disease that is characterized by rectal bleeding, congested and granular mucosa without ulceration and abnormal and coalescing hyperplastic lymphoid follicles without acute inflammatory changes. The lesions are usually confined to the rectal mucosa. LFP therapy is not well defined. Herein, we present a case of LFP that was resolved with a rapid administration of mesalazine enemas. A 35-year-old male was admitted to our hospital due to intermittent rectal bleeding associated with stools...
June 22, 2018: Revista Española de Enfermedades Digestivas
Wei Zhang, Meimei Wang, Shuang Wang, Hongchu Bao, Qinglan Qu, Ning Zhang, Cuifang Hao
OBJECTIVE: To compare the clinical outcomes of follicular versus luteal phase ovarian stimulation in women with poor ovarian response (Bologna criteria) undergoing IVF. METHODS: This retrospective study investigated 446 patients submitted to 507 cycles in three groups. First, the two larger cohorts were examined: 154 patients treated with luteal phase ovarian stimulation (Group Lu); and 231 patients administered follicular phase ovarian stimulation (Group Fo). Then the clinical outcomes of 61 patients submitted to double ovarian stimulation were analyzed...
June 22, 2018: JBRA Assisted Reproduction
R A Lemcke, C S Stephens, K A Hildebrandt, P A Johnson
Anti-Müllerian hormone (AMH) helps maintain the ovarian reserve by regulating primordial follicle activation and follicular selection in mammals, although its role within the avian ovary is unknown. In mammals, AMH is primarily produced in granulosa cells of preantral and early antral follicles. Similarly, in the hen, the granulosa cells of smaller follicles are the predominant source of AMH. The importance of AMH in mammalian ovarian dynamics suggests the protein and its specific Type II receptor, AMHRII, may have conserved functions in the hen...
June 19, 2018: Biology of Reproduction
Mozhgan Karimifar
Thyroid follicular cancers are one of the thyroid gland cancers. This cancer can lead to metastases to various areas of the body. We describe a patient with thyroid follicular carcinoma who after total thyroidectomy had severe hypercalcemia, increased creatinine, and thyrotoxicosis due to extensive bone metastases. The patient was a 52-year-old man who had femoral neck fracture as the first manifestation of thyroid cancer. He was hospitalized for some time after orthopedic measures because of thyrotoxicosis and deep-venous thrombosis...
2018: Advanced Biomedical Research
Jeong-Whun Kim, Seung Hoon Lee, Hong Joong Kim, Chae-Seo Rhee, Seung-No Hong
OBJECTIVE: Our aim was to radiographically and histologically characterize the tongue base tissues removed after robotic surgery and to analyze their relationship with polysomnographic measurements in obstructive sleep apnea. METHODS: Medical records, radiographs and histologic specimen of the patients who underwent transoral robotic tongue base reduction surgery were retrospectively reviewed. Findings in computed tomography (CT) images, histopathological features of the removed tongue base tissues, and respiratory parameters in polysomnography were compared and analyzed...
June 18, 2018: Auris, Nasus, Larynx
Thomas J Semrad, Theresa Keegan, Alison M Semrad, Ann Brunson, D Gregory Farwell
BACKGROUND: In an era of rising differentiated thyroid cancer incidence, the rate and impact of neck reoperation may inform the intensity of earlier interventions and surveillance. In this study, we sought to define predictors of neck reoperation and to assess its impact on survival. METHODS: Using California Cancer Registry linked to California Office of Statewide Health Planning and Development records, we performed a retrospective cohort study of 24,230 patients with total or near total thyroidectomy for papillary or follicular thyroid cancer during 1991-2008 and follow up through 2013...
June 21, 2018: Thyroid: Official Journal of the American Thyroid Association
Vijayakumar Velu, Geetha Mylvaganam, Chris Ibegbu, Rama Rao Amara
T follicular helper CD4 cells (Tfh) are essential for the development and maintenance of germinal center (GC) reactions, a critical process that promotes the generation of long-lived high affinity humoral immunity. It is becoming increasingly evident that GC-Tfh cells are heterogeneous in nature with some cellular characteristics associated with a Th1, Th2, and Th17 phenotype. Emerging studies suggest that GC-Tfh cells are directed to differentiate into distinct phenotypes during chronic HIV/SIV infection and these changes in GC-Tfh cells can greatly impact the B cell response and subclass of antibodies generated...
2018: Frontiers in Immunology
Reem Akel, Ghina Fakhri, Rana Salem, Fouad Boulos, Khaled Habib, Arafat Tfayli
Background: Follicular dendritic cell sarcoma (FDCS) is an extremely rare malignant tumor caused by proliferation of antigen-presenting follicular dendritic cells. The tumor most commonly arises in lymph nodes, with fewer than 30% of cases originating in extranodal sites. Case Presentation: We report the case of a 39-year-old previously healthy male patient who presented with paraneoplastic pemphigus in the setting of a large intraperitoneal mass with no associated lymphadenopathy...
May 2018: Case Reports in Oncology
Pinar Incel Uysal, Onder Bozdogan, Ahmet Atilan, Basak Yalcin
We report a juvenile case of mycosis fungoides with prominent follicular mucinosis (FM). The patient was a 9-year old boy who presented with a 2-month history of enlarging alopecic patch with fine scales on the scalp. Dermatologic examination revealed orange-tan slightly palpable plaques with follicular prominence on his trunk. The patient and his family were not aware of these asymptomatic truncal plaques. Histopathologic examination of both-scalp and trunk-lesions revealed folliculotropic lymphocytic infiltration with mucin...
January 23, 2018: American Journal of Dermatopathology
Mike Fillon
No abstract text is available yet for this article.
June 21, 2018: CA: a Cancer Journal for Clinicians
Chen Liu
We are very pleased to hear from Prof. Luis Graca and his colleagues. Their study plays an important role in improving the understanding of the significance of Tfr cells in RA, and raised key points for this issue, which is of great significance for further in-depth research. First we would like to explain some details about our research (1). This article is protected by copyright. All rights reserved.
June 21, 2018: Arthritis & Rheumatology
Tatjana Zake, Sandra Skuja, Ieva Kalere, Ilze Konrade, Valerija Groma
Th17 cells together with their hallmark cytokine interleukin (IL)-17 were identified as crucial contributing factors in the pathogenesis of thyroid autoimmunity. The cytokine-regulated tight junction (Tj) disruption is thought to be essential in the initiation and/or development of several diseases. Still, the role of IL-17 maintaining Tj integrity in autoimmune thyroid diseases (AITDs) has not yet been evaluated. We aimed to investigate integrity of the thyroid follicle by studying immunoexpression of cellular Tj - zonula occludens (ZO)-1 and claudin-1 proteins coupled to IL-17A and CD68 detection in AITD patients compared with controls...
June 2018: Medicine (Baltimore)
Fredrik Salvesen Haukaas, Audun Ohna, Tania Krivasi
AIMS: To evaluate the cost-effectiveness of obinutuzumab in combination with bendamustine followed by obinituzumab maintenance (Obin-Benda) compared to bendamustine alone (Benda) in patients with refractory follicular lymphoma (FL) in a Norwegian setting. METHODS: A three-state area-under-the-curve (AUC) model was developed. The states included were progression-free-survival (PFS), progressed disease (PD), and death. Each state had costs and utilities assigned to it...
June 19, 2018: Applied Health Economics and Health Policy
Kimberly Point du Jour, Alessandra C Schmitt, Amy Y Chen, Christopher C Griffith
In the original publication, the author name Kimberly Point du Jour was incorrectly captured. The correct Given name should be Kimberly and the Family name should be Point du Jour. The correct author name is presented in this correction article.
June 19, 2018: Endocrine Pathology
A Gaudchau, N Pfeiffer, A Gericke
We present a case of a toxic reaction in both eyes caused by secretions from an encrusting anemone of the genus Protopalythoa. The patient presented with chemosis and follicular reaction of the conjunctiva and whitish spots on the limbus. Under local treatment with steroids and antibiotic eyedrops, remission was achieved within a few days. Palytoxin, a poisonous component of Protopalythoa secretions, leads to inhibition of the sodium-potassium-ATPase, to destabilization of the membrane potential and to cell death...
June 19, 2018: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
Wael M Al-Amoudi
Lambda-cyhalothrin (LCT) is a synthetic pyrethroid that is widely used to control insecticide. Ginger is a traditional plant that is widely used as a spice or folk medicine. This study evaluates the antioxidant effect of ginger extract on thyroid toxicity induced by LCT in albino rats. Adult Rats were divided into 4 experimental groups: Group 1: control, Group 2: oral ginger treatment (24 mg/ml, 3 days/week for 4 weeks), Group 3: oral LCT treatment (1/100 LD50 , 3 days/week for 4 weeks), Group 4: oral LCT and ginger mixture treatment...
2018: Toxicology Reports
Disha Arora, Niti Singh, Veena Doda
No abstract text is available yet for this article.
May 2018: Journal of Family & Community Medicine
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