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https://www.readbyqxmd.com/read/28822903/uterine-clinical-findings-fertility-rate-leucocyte-migration-and-cox-2-protein-levels-in-the-endometrial-tissue-of-susceptible-mares-treated-with-platelet-rich-plasma-before-and-after-ai
#1
Lorenzo G Segabinazzi, Aime M Friso, Sebastian B Correal, André M Crespilho, José Antonio Dell'Aqua, Jordi Miró, Frederico O Papa, Marco Antonio Alvarenga
Persistent mating-induced endometritis (PMIE) results in decreased fertility in horses, thereby causing a significant impact in the horse market. Platelet-rich plasma (PRP), a modulator of the inflammatory response, has been largely used in veterinary medicine. Here, we investigated the effects of PRP on uterine inflammation, conception rate, endometrial polymorphonuclear neutrophil (PMN) migration, and COX-2 protein levels in the endometrial tissue. Thirteen PMIE-susceptible mares were used for artificial insemination (AI)...
August 12, 2017: Theriogenology
https://www.readbyqxmd.com/read/28822776/assessment-of-ovarian-follicular-dynamics-and-folliculogenesis-associated-endocrine-profiles-following-gonadotropin-stimulation-in-the-bonnet-monkey
#2
Bhupathi Sukesh, Muraly Puttabyatappa, Augustine T Peter, Rudraiah Medhamurthy, Polani B Seshagiri
We evaluated ovarian follicular dynamics in bonnet monkeys by employing trans-abdominal ultrasonography. Following the administration of human follicle stimulating hormone (hFSH) and/or human menopausal gonadotropin (hMG), multiple follicular development was assessed and their numbers, size and growth profiles were monitored. The ultrasonograms showed that the follicular antrum appeared distinctly anechoic with well-defined hyperechoic borders. Depending on the type, quantity (12.5-25 IU), and duration (6-9 days) of hormones administered, the number of developing follicles was 2-12 per ovary with their lowest diameter being 2 mm...
August 16, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28822459/oral-propylene-glycol-modifies-follicular-fluid-and-gene-expression-profiles-in-cumulus-oocyte-complexes-and-embryos-in-feed-restricted-heifers
#3
G Gamarra, C Ponsart, S Lacaze, F Nuttinck, A Cordova, P Mermillod, B Marquant-Le Guienne, D Monniaux, P Humblot, A A Ponter
Dietary supplementation with propylene glycol (PG) increases in vitro production of high-quality embryos in feed-restricted heifers. The aim of the present study was to evaluate the effects of PG in feed-restricted heifers on follicular fluid insulin and insulin-like growth factor (IGF) 1 concentrations, expression of IGF system genes in oocytes and cumulus cells and the expression of selected genes in blastocysts. Feed-restricted (R) heifers were drenched with water or PG during induced oestrous cycles (400mL of PG or water/drench, daily drenching at 1600 hours for the first 9 days of the oestrous cycle)...
August 21, 2017: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/28822443/-follicular-lymphoma-with-minimal-change-nephrotic-syndrome-in-a-child
#4
Z B Yang, Y Liu, Z H Zhang
No abstract text is available yet for this article.
August 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/28821386/serum-and-follicular-fluid-testosterone-concentrations-do-not-correlate-questioning-the-impact-of-androgen-supplementation-on-the-follicular-endocrine-milieu
#5
Michael von Wolff, Petra Stute, Markus Eisenhut, Ulrich Marti, Norman Bitterlich, Nick A Bersinger
Basic research into a possible link between serum and follicular fluid androgen concentrations to detemine whether androgen supplementation in low responders affects follicular endocrine milieu is still lacking. Ninety-seven women (aged 28-43 years) undergoing one natural IVF cycle without any hormone stimulation were analysed. Serum and follicular fluid were collected at the time of follicle aspiration, and the concentrations of LH, total testosterone, oestradiol, dehydroepiandrosterone and anti-Mullerian hormone (AMH) were determined...
August 2, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28821194/primary-benign-and-malignant-thyroid-neoplasms-with-signet-ring-cells-cytologic-histologic-and-molecular-features
#6
Nada A Farhat, Ayse M Onenerk, Jeffrey F Krane, Dora Dias-Santagata, Peter M Sadow, William C Faquin
Objectives: Signet ring cells (SRCs) can be seen in a variety of thyroid tumors and can pose a diagnostic pitfall on cytology. This study describes the cytologic, histomorphologic, and molecular aspects of a cohort of primary thyroid tumors with SRCs. Methods: A search was performed of the Massachusetts General Hospital and Brigham and Women's Hospital (Boston, MA) pathology archives for the keywords thyroid, signet, and signet ring features between 2000 and 2014...
September 1, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28821191/impact-of-noninvasive-follicular-thyroid-neoplasm-with-papillary-like-features-on-adequacy-criteria-and-risk-of-malignancy-of-thyroid-fine-needle-aspiration
#7
Andrew A Renshaw, Edwin W Gould
Objectives: The impact of noninvasive follicular thyroid neoplasm with papillary-like features (NIFTP) on nondiagnostic and benign diagnoses is not well characterized. Methods: The results of all thyroid fine-needle aspirates (FNAs) performed from 1997 to June 2016 with corresponding resections were reviewed. Results: From 12,764 aspirates, there were 8,106 (64%) benign diagnoses with 412 (5%) resections and 1,888 (14.8%) nondiagnostic diagnoses with 329 (17%) resections...
September 1, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28820403/high-levels-of-soluble-vascular-endothelial-growth-factor-receptor-1-sflt1-and-low-levels-of-vascular-endothelial-growth-factor-in-follicular-fluid-on-the-day-of-oocyte-retrieval-correlate-with-ovarian-hyperstimulation-syndrom-regardless-of-the-stimulation
#8
A J Jakimiuk, M A Nowicka, M Zagozda, K Koziol, P Lewandowski, T Issat
The aim of the study was to assess the predictive value of vascular endothelial growth factor (VEGF), its soluble receptor - sVEGF-R1/sFlt1 and endocrine gland-derived vascular endothelial growth factor (EG-VEGF) concentrations in serum and follicular fluid (FF) for ovarian hyperstimulation syndrome (OHSS) in women undergoing controlled ovarian hyperstimulation (COH) protocols. Patients have been divided into 3 groups: control group on natural cycle, patients stimulated with GnRH agonist and patients stimulated with GnRH antagonist...
June 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/28819333/expression-of-autophagy-related-proteins-in-h%C3%A3-rthle-cell-neoplasm-is-different-from-that-in-follicular-neoplasm
#9
Yoon Jin Cha, Hye Min Kim, Ja Seung Koo
PURPOSE: We aimed to evaluate expression of autophagy-related proteins in Hürthle cell neoplasm (HCN) and follicular neoplasm (FN) and assess the clinical implications. METHODS: 265 FNs (112 follicular carcinomas and 153 follicular adenomas) and 108 HCNs (27 Hürthle cell carcinomas and 81 Hürthle cell adenomas) were made into a tissue microarray. Immunohistochemical staining and Western blot for autophagy-related proteins (beclin-1, light chain (LC) 3A, LC3B, p62, and BNIP3) were performed, and the results were statistically analyzed...
2017: Disease Markers
https://www.readbyqxmd.com/read/28819292/vitrification-versus-slow-freezing-for-human-ovarian-tissue-cryopreservation-a-systematic-review-and-meta-anlaysis
#10
Qingquan Shi, Yidong Xie, Yan Wang, Shangwei Li
Vitrification is a well-accepted procedure for cryopreservation of gametes and embryos. Less is known, however, about its performance in preserving ovarian tissue, for which slow freezing is the current convention. Increasing interest is being focused on vitrification, but there are as yet no standard protocols for its use with ovarian tissue. In part, this is because of the variety of cell types and complex nature of ovarian tissue. We performed a meta-analysis of 14 studies that compared vitrification with slow freezing for cryopreservation of ovarian tissue...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28818832/b-cell-ox40l-supports-t-follicular-helper-cell-development-and-contributes-to-sle-pathogenesis
#11
Andrea Cortini, Ursula Ellinghaus, Talat H Malik, Deborah S Cunningham Grahman, Marina Botto, Timothy James Vyse
OBJECTIVES: TNFSF4 (encodes OX40L) is a susceptibility locus for systemic lupus erythematosus (SLE). Risk alleles increase TNFSF4 expression in cell lines, but the mechanism linking this effect to disease is unclear, and the OX40L-expressing cell types mediating the risk are not clearly established. Blockade of OX40L has been demonstrated to reduce disease severity in several models of autoimmunity, but not in SLE. We sought to investigate its potential therapeutic role in lupus. METHODS: We used a conditional knockout mouse system to investigate the function of OX40L on B and T lymphocytes in systemic autoimmunity...
August 17, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28817118/altered-marginal-zone-and-innate-like-b-cells-in-aged-senescence-accelerated-samp8-mice-with-defective-igg1-responses
#12
Isabel Cortegano, Mercedes Rodríguez, Isabel Martín, Maria Carmen Prado, Carolina Ruíz, Rafael Hortigüela, Mario Alía, Marçal Vilar, Helena Mira, Eva Cano, Mercedes Domínguez, Belén de Andrés, María Luisa Gaspar
Aging has a strong impact on the activity of the immune system, enhancing susceptibility to pathogens and provoking a predominant pre-inflammatory status, whereas dampening responses to vaccines in humans and mice. Here, we demonstrate a loss of marginal zone B lymphocytes (MZ, CD19(+)CD45R(+)CD21(++)CD23(lo)) and a decrease of naive B cells (CD19(+)IgD(+)), whereas there is an enhancement of a CD19(+)CD45R(lo) innate-like B cell population (B1REL) and the so-called aged B cell compartment (ABC, CD45R(+)CD21(lo)CD23(lo)CD5(-)CD11b(-)) in aged senescence-accelerated (SAMP8) mice but not in aged senescence-resistant (SAMR1) mice...
August 17, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28817115/administration-of-follicle-stimulating-hormone-induces-autophagy-via-upregulation-of-hif-1%C3%AE-in-mouse-granulosa-cells
#13
Jilong Zhou, Wang Yao, Chengyu Li, Wangjun Wu, Qifa Li, Honglin Liu
Recent studies reported the important role of autophagy in follicular development. However, the underlying molecular mechanisms remain elusive. In this study, we investigated the effect of follicle-stimulating hormone (FSH) on mouse granulosa cells (MGCs). Results indicated that autophagy was induced by FSH, which is known to be the dominant hormone regulating follicular development and granulosa cell (GC) proliferation. The activation of mammalian target of rapamycin (mTOR), a master regulator of autophagy, was inhibited during the process of MGC autophagy...
August 17, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28816924/treatment-of-premenstrual-breakthrough-of-depression-with-adjunctive-oral-contraceptive-pills-compared-with-placebo
#14
Whitney Peters, Marlene P Freeman, Semmie Kim, Lee S Cohen, Hadine Joffe
PURPOSE/BACKGROUND: Two-thirds of women with depressive disorders report reemergence of depression premenstrually, or premenstrual exacerbation (PME), despite effective treatment of the underlying mood disorder during the remainder of the cycle. There is a paucity of studies that rigorously assess treatments targeting PME. Open-label data suggest that augmentation of antidepressants with the oral contraceptive pill (OCP) drospirenone and ethinyl estradiol (DRSP/EE) improves depressive symptoms that break through treatment premenstrually...
August 15, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28816743/elastic-staining-in-differentiating-between-follicular-streamers-and-follicular-scars-in-horizontal-scalp-biopsy-sections
#15
Timothy Tan, Joan Guitart, Pedram Gerami, Pedram Yazdan
BACKGROUND: Accurate identification of follicular streamers versus follicular scars on horizontal scalp biopsy sections is important to differentiate between cicatricial and noncicatricial alopecias. However, distinguishing between them can be difficult especially in nonoptimal specimens. The utility of elastic Verhoeff-Van Gieson (EVG) stain in cicatricial alopecias has been described on vertical sections, but its evaluation on horizontal sections has not been performed. METHODS: Sixty-four cicatricial alopecias (25 lichen planopilaris, 29 central centrifugal cicatricial alopecias, and 10 discoid lupus erythematosus) and 53 noncicatricial alopecias (34 androgenic alopecia, 8 telogen effluvium, and 11 alopecia areata) were identified, and EVG staining was performed on horizontal sections...
August 9, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28816737/necrotizing-infundibular-crystalline-folliculitis-an-unusual-clinical-presentation-and-demonstration-of-the-presence-of-calcium-palmitate
#16
Aurélie Beaufrère, Valérie Garcia, Vincent Frochot, Thierry Molina, Michel Daudon, Sylvie Fraitag
Necrotizing infundibular crystalline folliculitis (NICF) is a rare disorder, which was described for the first time by Lucke et al in 1999. NICF is characterized by multiple folliculocentric papules with a predilection for occurring in seborrheic areas in adults and corresponding dilated follicular ostia containing crystalline material. The precise pathogenesis and nature of this crystalline material are currently unknown. Here, we report an unusual case of NICF presented as an uncommon generalized skin rash in an adolescent...
August 8, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28816516/vibrio-vulnificus-vvha-induces-th1-and-tfh-cells-to-proliferate-against-vibrio-vulnificus-in-a-mouse-model-of-infection
#17
Ming-Yi Wang, Xiao-Fei Liu, Jun Xia, Yu Li, Jian-Li Geng, Cheng-Jin Hu
AIM: To characterize the roles of VvhA in host's acquired immune response to Vibrio vulnificus infection. MATERIALS & METHODS: The recombinant VvhA fusion protein was used to immunize mice and the anti-VvhA polyclonal antibody was produced in vivo for prophylactic and therapeutic efficacy assay. The roles of VvhA in T helper (Th) cells differentiation were analyzed by vvhA-deleted mutant during the early phase of infection, while the ratio of Th2 and T follicular helper (Tfh) cells were examined in VvhA immunization...
August 17, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28816214/synchronous-malignancies-of-thyroglossal-duct-cyst-and-thyroid-gland
#18
Chinna Naik, Sandip Basu
Malignant involvement of thyroglossal duct cyst is rare, still rarer is the synchronous malignant involvement of the thyroid gland. Although the Sistrunk procedure is often regarded as adequate, controversy exists of the need for an additional total thyroidectomy and radioiodine ablative therapy, the decision of which depends upon the presence of (i) suspicious thyroid gland nodule; (ii) presence of lymphadenopathy; or (iii) a previous history of neck irradiation. We report a 47-year-old woman diagnosed with papillary carcinoma within a recurrent thyroglossal duct cyst with infiltration into surrounding soft tissues and a suspicious thyroid nodule of the left thyroid lobe with no regional lymph node involvement...
March 2017: National Medical Journal of India
https://www.readbyqxmd.com/read/28814605/adam10-mediated-icos-ligand-shedding-on-b-cells-is-necessary-for-proper-t-cell-icos-regulation-and-t-follicular-helper-responses
#19
Joseph C Lownik, Andrea J Luker, Sheela R Damle, Lauren Folgosa Cooley, Riham El Sayed, Andreas Hutloff, Costantino Pitzalis, Rebecca K Martin, Mohey Eldin M El Shikh, Daniel H Conrad
The proper regulation of ICOS and ICOS ligand (ICOSL) has been shown to be essential for maintaining proper immune homeostasis. Loss of either protein results in defective humoral immunity, and overexpression of ICOS results in aberrant Ab production resembling lupus. How ICOSL is regulated in response to ICOS interaction is still unclear. We demonstrate that a disintegrin and metalloproteinase (ADAM)10 is the primary physiological sheddase of ICOSL in mice and humans. Using an in vivo system in which ADAM10 is deleted only on B cells, elevated levels of ICOSL were seen...
August 16, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28814600/fungating-groin-mass-in-a-woman-with-a-history-of-follicular-lymphoma
#20
Kunal Bailoor, Tony Chen
No abstract text is available yet for this article.
August 16, 2017: BMJ Case Reports
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