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Alginic acid

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https://www.readbyqxmd.com/read/28926758/some-aspects-of-the-iodine-metabolism-of-the-giant-kelp-macrocystis-pyrifera-phaeophyceae
#1
Teresa M Tymon, Eric P Miller, Jennifer L Gonzales, Andrea Raab, Frithjof C Küpper, Carl J Carrano
Despite its paramount role in the functioning of coastal ecosystems, relatively little is known about halogen metabolism in giant kelp (Macrocystis pyrifera). This is an important shortcoming given the potential implications for marine and atmospheric chemical processes in the wide distribution range of Macrocystis. The work presented here constitutes the first in depth investigation of the uptake, efflux, and of the physiological function of iodide in this important kelp species. Iodide uptake and efflux rates were measured in adult sporophytes of Macrocystis under normal and stressed (exogenous hydrogen peroxide and an elicitor-triggered oxidative burst) conditions...
September 8, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28923769/reconstitutable-spray-dried-ultra-fine-dispersion-as-a-robust-platform-for-effective-oral-delivery-of-an-antihyperlipidemic-drug
#2
Mona Basha, Alaa H Salama, Sally El Awdan
The current article highlights the application of spray drying technique to produce an ultra-fine powder encapsulating the antihyperlipidemic drug, atorvastatin calcium (ATV). First, ATV was dissolved in an emulsion formulation, and different carriers (pectin, alginate, chitosan HCl and hydroxypropylmethyl cellulose) in two concentrations (1.5 and 3%) were added. Then, these carrier-containing formulations were subjected to spray drying, whereby ultra-fine ATV-loaded spray dried emulsions were produced (ATV-SDE)...
September 15, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28919419/binding-mode-of-metal-ions-to-the-bacterial-iron-import-protein-efeo
#3
Kanate Temtrirath, Kenji Okumura, Yukie Maruyama, Bunzo Mikami, Kousaku Murata, Wataru Hashimoto
The tripartite EfeUOB system functions as a low pH iron importer in Gram-negative bacteria. In the alginate-assimilating bacterium Sphingomonas sp. strain A1, an additional EfeO-like protein (Algp7) is encoded downstream of the efeUOB operon. Here we show the metal binding mode of Algp7, which carries a M_75 metallopeptidase motif. The Algp7 protein was purified from recombinant E. coli cells and was subsequently characterized using differential scanning fluorimetry, fluorescence spectrometry, atomic absorption spectroscopy, and X-ray crystallography...
September 14, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28917913/microparticle-embedded-fibroin-alginate-beads-for-prolonged-local-release-of-simvastatin-hydroxyacid-to-mesenchymal-stem-cells
#4
F Ungaro, O Catanzano, I d'Angelo, L Diaz-Gomez, A Concheiro, A Miro, C Alvarez-Lorenzo, F Quaglia
In the present work, we propose silk fibroin/alginate (SF/Alg) beads embedding simvastatin-loaded biodegradable microparticles as a versatile platform capable of tuning SVA release and in so doing osteogenic effects. In a first part of the study, microparticles of poly(lactic-co-glycolic) acid incorporating simvastatin either as lactone (SVL) or as hydroxyacid form (SVA) were prepared by spray-drying. While SVA-loaded microparticles released the drug in three days, long-term release of SVA could be obtained from SVL-loaded microparticles...
November 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28917856/the-effect-of-ionic-and-non-ionic-surfactants-and-ph-on-the-stability-adsorption-and-electrokinetic-properties-of-the-alginic-acid-alumina-system
#5
E Grządka, J Matusiak
The influence of ionic (CTAB; SDS) and non-ionic (TX-100; TX-165 and TX-405) surfactants as well as pH of the solution on the stability, adsorption and electrokinetic properties of the alginic acid (AA)/alumina (Al2O3) suspensions was studied. The results obtained using the spectrophotometric method show that the addition of ionic surfactants is an effective way to obtain stable AA/Al2O3 suspensions whereas the changes in pH are not sufficient. Surface tension measurements together with the adsorption data show that the macromolecules of alginic acid are able to form complexes with CTAB, however, they compete for the adsorption centers on the metal oxide surface with SDS...
November 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28915492/enhancement-of-5-aminolevulinic-acid-phototoxicity-by-encapsulation-in-polysaccharides-based-nanocomplexes-for-photodynamic-therapy-application
#6
Antonio Di Martino, Alena Pavelkova, Pavel S Postnikov, Vladimir Sedlarik
Polysaccharides based nanocomplexes have been developed for encapsulation, controlled delivery and to enhance the phototoxicity of the photosensitizer 5-aminolevulinic acid for application in photodynamic therapy. The nanocomplexes were prepared by coacervation in a solvent free environment using chitosan as polycation while alginic and polygalacturonic acid as polyanions. The complexes showed average dimension in the range 90-120nm, good stability in simulated physiological media and high drug encapsulation efficiency, up to 800μg per mg of carrier...
August 8, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28914533/m%C3%A3-ssbauer-spectroscopic-characterization-of-iron-iii-polysaccharide-coordination-complexes-photochemistry-biological-and-photoresponsive-materials-implications
#7
Hendrik Auerbach, Giuseppe E Giammanco, Volker Schünemann, Alexis D Ostrowski, Carl J Carrano
While polycarboxylates and hydroxyl-acid complexes have long been known to be photoactive, simple carboxylate complexes which lack a significant LMCT band are not typically strongly photoactive. Hence, it was somewhat surprising that a series of reports demonstrated that materials synthesized from iron(III) and polysaccharides such as alginate (poly[guluronan-co-mannuronan]) or pectate (poly[galacturonan]) formed photoresponsive materials that convert from hydrogels to sols under the influence of visible light...
September 15, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28914392/alginate-hyaluronic-acid-hydrogel-delivery-system-characteristics-regulate-the-differentiation-of-periodontal-ligament-stem-cells-toward-chondrogenic-lineage
#8
Sahar Ansari, Ivana M Diniz, Chider Chen, Tara Aghaloo, Benjamin M Wu, Songtao Shi, Alireza Moshaverinia
Cartilage tissue regeneration often presents a challenging clinical situation. Recently, it has been shown that Periodontal Ligament Stem Cells (PDLSCs) possess high chondrogenic differentiation capacity. In this study, we developed a stem cell delivery system based on alginate/hyaluronic acid (HA) loaded with TGF-β1 ligand, encapsulating PDLSCs; and investigated the chondrogenic differentiation of encapsulated cells in alginate/HA hydrogel microspheres in vitro and in vivo. The results showed that PDLSCs, as well as human bone marrow mesenchymal stem cells (hBMMSCs), as the positive control, were stained positive for both toluidine blue and alcian blue staining, while exhibiting high levels of gene expression related to chondrogenesis (Col II, Aggrecan and Sox-9), as assessed via qPCR...
September 15, 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28914179/neutralization-of-acidic-drainage-by-cryptococcus-sp-t1-immobilized-in-alginate-beads
#9
Masahiko Okai, Chisato Suwa, Shintaro Nagaoka, Nobuo Obara, Daisuke Mitsuya, Ayako Kurihara, Masami Ishida, Naoto Urano
We isolated Cryptococcus sp. T1 from Lake Tazawa's acidic water in Japan. Cryptococcus sp. T1 neutralized an acidic casamino acid solution (pH 3.0) and released ammonia from the casamino acids to aid the neutralization. The neutralization volume was estimated to be approximately 0.4 mL/h. The casamino acids' amino acids decreased (1.24→0.15 mM); ammonia increased (0.22→0.99 mM). We neutralized acidic drainage water (1 L) from a Tamagawa River neutralization plant, which was run through the column with the T1-immobilized alginate beads at a flow rate of 0...
September 15, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28910183/the-effects-of-barrier-agents-in-postoperative-pelvic-adhesion-formation-a-comparative-study-of-a-temperature-sensitive-poloxamer-based-solution-gel-and-a-hyaluronic-acid-based-solution-in-a-rat-uterine-horn-model
#10
Hyeon-Ji Kim, Hyun Kang, Mi-Kyung Kim, Seung-Su Han
OBJECTIVE: The aim is to evaluate the efficacy of poloxamer/alginate/CaCl2 mixture (PACM) solution/gel and hyaluronic acid/carboxymethylcellulose (HA-CMC) solution for reducing pelvic adhesion in a rat uterine horn model. STUDY DESIGN: A total of 48 females, Sprague Dawley rats, were divided into three groups according to the applied materials. A uterine horn adhesion model was created. The control group (group CO; n = 16) received no special materials except saline infusion...
September 14, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28902456/safety-and-efficacy-of-hydroxyapatite-scaffold-in-the-prevention-of-jaw-osteonecrosis-in-vivo
#11
Adriana Duarte de Almeida, Fernanda Gomes Leite, Marco Vinícius Chaud, Márcia de Araújo Rebelo, Liliane Cristine Ferreira de Souza Borges, Fabia Judice Marques Viroel, Alessandre Hataka, Denise Grotto
Two scaffolds of chitosan/sodium alginate/hydroxyapatite (Ch/NaAlg/Hap) 1:1:0.2 and 1:1:0.6 were evaluated in the prevention of bisphosphonate-induced jaw osteonecrosis. Two groups of rats (n = 24, according to the euthanasia time: 15 or 30 days after the last Zoledronic acid (ZA) administration) were subdivided in four subgroups (n = 6): I - Control (saline + teeth extraction); II - ZA 0.6 mg/kg + teeth extraction; III - ZA + teeth extraction + scaffold 1:1:0.2; IV - ZA + teeth extraction + scaffold 1:1:0...
September 13, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28901673/catanionic-coacervate-micro-droplets-as-a-surfactant-based-membrane-free-protocell-model
#12
Jean-Paul Douliez, Nicolas Martin, Stephen Mann, Cédric Gaillard, Thomas Beneyton, Jean-Christophe Baret, Laure Beven
We report on the formation of surfactant complex catanionic coacervate micro-droplets in mixtures of decanoic acid and cetyl pyridinium chloride or cetyl trimethyl ammonium bromide. We show that coacervation occurs over a broad range of composition, pH and ionic strength. The catanionic coacervates consist of elongated micelles, sequester a wide range of solutes including water-soluble organic dyes, polysaccharides, proteins, enzymes and DNA, and can be structurally stabilized by sodium alginate or gelatin-based hydrogelation...
September 13, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28893657/the-effect-of-adjuvant-treatment-to-prevent-and-treat-intrauterine-adhesions-a-network-meta-analysis-of-randomized-controlled-trials
#13
REVIEW
Yu Yan, Dongmei Xu
Intrauterine adhesions (IUA) can lead to partial or complete closure of the uterine cavity, which may result in symptoms including abnormal menstruation, infertility, and pelvic pain. A network meta-analysis was performed to assess the effect of adjuvant therapy on the prevention and treatment of intrauterine adhesions. We searched electronic databases, including PubMed, EmBase, and the Cochrane Library, up to May 5, 2017 without language restrictions. The primary outcomes in the present analysis were the rate of IUAs for prevention and the rate of IUA recurrence for treatment...
September 8, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28880273/tailored-therapy-guided-by-multichannel-intraluminal-impedance-ph-monitoring-for-refractory-non-erosive-reflux-disease
#14
Nunzio Ranaldo, Giuseppe Losurdo, Andrea Iannone, Mariabeatrice Principi, Michele Barone, Massimo De Carne, Enzo Ierardi, Alfredo Di Leo
A relevant percentage of non-erosive reflux disease (NERD) is refractory to proton pump inhibitors (PPIs) treatment. Multichannel intraluminal impedance pH (MII-pH) monitoring should give useful pathophysiological information about refractoriness. Therefore, our aim was to assess whether this technique could be useful to guide a 'tailored' therapy in refractory NERD. We retrospectively recruited NERD patients undergoing MII-pH monitoring for unsuccessful treatment. All patients had undergone upper endoscopy, and those with erosive esophagitis were excluded...
September 7, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28874846/hyaluronic-acid-coated-chitosan-nanoparticles-reduced-the-immunogenicity-of-the-formed-protein-corona
#15
Abdulaziz Almalik, Hicham Benabdelkamel, Afshan Masood, Ibrahim O Alanazi, Ibrahim Alradwan, Majed A Majrashi, Assim A Alfadda, Waleed M Alghamdi, Haitham Alrabiah, Nicola Tirelli, Ali H Alhasan
Studying the interactions of nanoparticles (NPs) with serum proteins is necessary for the rational development of nanocarriers. Optimum surface chemistry is a key consideration to modulate the formation of the serum protein corona (PC) and the resultant immune response. We investigated the constituent of the PC formed by hyaluronic acid-coated chitosan NPs (HA-CS NPs). Non-decorated chitosan NPs (CS NPs) and alginate-coated chitosan NPs (Alg-CS NPs) were utilized as controls. Results show that HA surface modifications significantly reduced protein adsorption relative to controls...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28873701/encapsulation-of-omega-3-fatty-acids-in-nanoemulsions-and-microgels-impact-of-delivery-system-type-and-protein-addition-on-gastrointestinal-fate
#16
Fang Chen, Guang-Qin Fan, Zipei Zhang, Ruojie Zhang, Ze-Yuan Deng, David Julian McClements
Carefully designed delivery systems are required to encapsulate and protect omega-3 fatty acids in commercial food and beverage products, but then release them at the required site-of-action within the human gastrointestinal tract (GIT). Previously, we showed that the oxidative stability of flaxseed oil (a plant-based source of omega-3 fatty acids) encapsulated in nanoemulsion droplets or calcium alginate microgels (hydrogel beads) was improved using caseinate as a natural antioxidant. In this study, the impact of caseinate on the digestion of flaxseed oil encapsulated in these delivery systems was investigated using a simulated GIT...
October 2017: Food Research International
https://www.readbyqxmd.com/read/28873554/influence-of-the-uronic-acid-composition-on-the-gastroprotective-activity-of-alginates-from-three-different-genus-of-tunisian-brown-algae
#17
Hiba Hadj Ammar, Sirine Lajili, Nawfel Sakly, Dora Cherif, Christophe Rihouey, Didier Le Cerf, Abderrahman Bouraoui, Hatem Majdoub
Alginates from three genus of Tunisian brown algae were isolated and characterized by size exclusion chromatography and Solid-state NMR spectroscopy. Alginate from Padina pavonica (APP) had the highest molecular weight (Mw) with 147,000g/mol while it was 85,000g/mol for alginate from Cystoseira compressa (ACC) and 58,000g/mol for alginate from Dictyopteris membranaceae (ADM). The mannuronate (M) to guluronate (G) ratios were estimated from spectral deconvolution of the (13)C CP/MAS spectra and the results has shown that all the extracts are mannuronic acid-rich alginates with M/G ratio increased in the order ADM - ACC - APP...
January 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/28872995/eva-vacuum-formed-alternative-splinting-of-alveolar-fractures-in-primary-dentition-a-case-report
#18
Konstantina Chatzidimitriou, Nikos N Lygidakis, Nick A Lygidakis
Alveolar fractures treatment includes repositioning of displaced segments and splinting. In children, splinting procedures may occasionally present clinical problems resulting from fewer teeth available for splinting or presence of occlusal disturbances. An alternative clinical approach for splinting in alveolar fractures of primary dentition is described. CLINICAL CASE: A 4.5-year-old girl was referred to our clinic 8 hours after a fall accident. Clinical examination revealed mandibular alveolar process segmental fracture in the right canine area with frontal dislodgement of the labial cortical bone resulting to occluding inability...
2017: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28862732/preparation-bioactivity-and-mechanism-of-nano-hydroxyapatite-sodium-alginate-chitosan-bone-repair-material
#19
Jianguo Liao, Yanqun Li, Haiyan Li, Jingxian Liu, Yufen Xie, Jianping Wang, Yongxiang Zhang
BACKGROUND: As the major inorganic component of natural bone, nano-hydroxyapatite (n-HA) on its own is limited in its use in bone repair, due to its brittleness. Chitosan (CS) and sodium alginate (SAL) are used to reduce its brittleness and tendency to degradation. However, the compressive strength of the composite is still low, and its biological performance needs further study. METHODS: Nano-hydroxyapatite/sodium alginate/chitosan (n-HA/SAL/CS) composite was prepared via an in situ synthesis method...
August 11, 2017: Journal of Applied Biomaterials & Functional Materials
https://www.readbyqxmd.com/read/28859383/effect-of-alginate-in-patients-with-gerd-hiatal-hernia-matters
#20
R Vardar, M Keskin, E Valitova, B Bayrakci, E Yildirim, S Bor
Alginate-based formulations are frequently used as add-on proton pump inhibitor (PPI) therapy to help control of heartburn and regurgitation. There are limited data regarding the mechanisms and effects of alginate-based formulations. We aimed to evaluate the effects of the sodium alginate intake and its likely temporal relations on intraesophageal reflux events by MII-pH in patients with and without hiatal hernia (HH). Fifty GERD patients (18 with HH, 32 without HH) with heartburn or regurgitation once a week or more common were included...
October 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
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