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Alginic acid

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https://www.readbyqxmd.com/read/28543702/microencapsulation-of-rifampicin-a-technique-to-preserve-the-mechanical-properties-of-bone-cement
#1
P Sanz-Ruiz, E Carbó-Laso, J C Del Real-Romero, F Arán-Ais, Y Ballesteros-Iglesias, E Paz-Jiménez, M Sánchez-Navarro, M A Pérez-Limiñana, J Vaquero-Martín
Two-stage exchange with antibiotic-loaded bone cement spacers remains the gold standard for chronic periprosthetic joint infection(PJI). Rifampicin is highly efficient on stationary-phase staphylococci in biofilm; however, its addition to PMMA to manufacture spacers prevents polymerization and reduces mechanical properties. Isolation of rifampicin during polymerization by microencapsulation could allow manufacturing rifampicin-loaded bone cement maintaining elution and mechanical properties. Microcapsules of rifampicin with alginate, polyhydroxybutyratehydroxyvalerate (PHBV), ethylcellulose and stearic acid (SA) were synthesized...
May 23, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28539647/physiological-concentrations-of-soluble-uric-acid-are-chondroprotective-and-anti-inflammatory
#2
Jenn-Haung Lai, Shue-Fen Luo, Li-Feng Hung, Chuan-Yueh Huang, Shiu-Bii Lien, Leou-Chyr Lin, Feng-Cheng Liu, B Linju Yen, Ling-Jun Ho
High uric acid levels are a risk factor for cardiovascular disorders and gout; however, the role of physiological concentrations of soluble uric acid (sUA) is poorly understood. This study aimed to clarify the effects of sUA in joint inflammation. Both cell cultures of primary porcine chondrocytes and mice with collagen-induced arthritis (CIA) were examined. We showed that sUA inhibited TNF-α- and interleukin (IL)-1β-induced inducible nitric oxide synthase, cyclooxygenase-2 and matrix metalloproteinase (MMP)-13 expression...
May 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28536020/%C3%B0-valuation-of-biocompatibility-and-antioxidant-efficiency-of-chitosan-alginate-nanoparticles-loaded-with-quercetin
#3
Denitsa Aluani, Virginia Tzankova, Magdalena Kondeva-Burdina, Yordan Yordanov, Elena Nikolova, Feodor Odzhakov, Alexandar Apostolov, Tzvetanka Markova, Krassimira Yoncheva
The present study deals with development and evaluation of the safety profile of chitosan/alginate nanoparticles as a platform for delivery of a natural antioxidant quercetin. The nanoparticles were prepared by varying the ratios between both biopolymers giving different size and charge of the formulations. The biocompatibility was explored in vitro in cells from different origin: cultivated HepG2 cells, isolated primary rat hepatocytes, isolated murine spleen lymphocytes and macrophages. In vivo toxicological evaluation was performed after repeated 14-day oral administration to rats...
May 20, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28530576/efficient-delivery-of-quercetin-after-binding-to-beta-lactoglobulin-followed-by-formation-soft-condensed-core-shell-nanostructures
#4
Seyedeh Fatemeh Mirpoor, Seyed Mohammad Hashem Hosseini, Abdo-Reza Nekoei
Nature-made inherent transporting property of beta-lactoglobulin (BLG) was exploited to develop delivery systems for quercetin. After binding to BLG, quercetin was nanoencapsulated within soft-condensed nanostructures of BLG and sodium alginate (ALG). Fluorimetry results revealed that quercetin could bind to BLG even at acidic conditions. The amounts of stoichiometry binding (n) were 1.24 and 1.62 at pH values of 4 and 7, respectively. Formation of core-shell type nanostructures was confirmed by transmission electron microscopy...
October 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28529037/diabetes-development-increased-concentrations-of-the-conjugated-bile-acid-taurocholic-acid-in-serum-while-treatment-with-microencapsulated-taurocholic-acid-exerted-no-hypoglycaemic-effects
#5
Sangeetha Mathavan, Momir Mikov, Svetlana Golocorbin-Kon, Hani Al-Salami
CONTEXT: The bile acid taurocholic acid (TCA) is endogenously produced, and has shown formulation-stabilising effects when incorporated into microcapsules containing potential antidiabetic drugs. This study aimed to develop and characterise TCA-microcapsules, and test their antidiabetic effects, in an animal model of Type 1 diabetes (T1D). METHODS: Using the polymer sodium alginate (SA), SA-microcapsules (control) and TCA-microcapsules (test) were prepared, and assessed for morphology, surface composition, chemical and thermal stability, swelling, buoyancy, mechanical, release and rheological properties...
May 18, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28528593/polymannuronic-acid-ameliorated-obesity-and-inflammation-associated-with-a-high-fat-and-high-sucrose-diet-by-modulating-the-gut-microbiome-in-a-murine-model
#6
Fang Liu, Xiong Wang, Hongjie Shi, Yuming Wang, Changhu Xue, Qing-Juan Tang
Polymannuronic acid (PM), one of numerous alginates isolated from brown seaweeds, is known to possess antioxidant activities. In this study, we examined its potential role in reducing body weight gain and attenuating inflammation induced by a high-fat and high-sucrose diet (HFD) as well as its effect on modulating the gut microbiome in mice. A 30-d PM treatment significantly reduced the diet-induced body weight gain and blood TAG levels (P2·0). PM also had a profound impact on the microbial composition in the gut microbiome and resulted in a distinct microbiome structure...
May 22, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28526341/preparation-and-characterization-of-amidated-derivatives-of-alginic-acid
#7
Tomáš Taubner, Milan Marounek, Andriy Synytsya
Alginic acid is a suitable material for modification to prepare new derivatives because of presence of its carboxyl groups. The high content of carboxyl groups over the entire length of its chain renders it an easily modifiable material with a possibility of achieving a high degree of substitution in the prepared derivatives. The salt of alginic acid (sodium alginate) is readily commercially available and is widely used in many branches of chemistry. Alginic acid was thus selected as the substrate for amidation...
May 17, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28523825/biphasic-supramolecular-self-assembly-of-ferric-ions-and-tannic-acid-across-interfaces-for-nanofilm-formation
#8
Beom Jin Kim, Sol Han, Kyung-Bok Lee, Insung S Choi
Cell nanoencapsulation provides a chemical tool for the isolation and protection of living cells from harmful, and often lethal, external environments. Although several strategies are available to form nanometric films, most methods heavily rely on time-consuming multistep processes and are not biocompatible. Here, the interfacial supramolecular self-assembly and film formation of ferric ions (Fe(III) ) and tannic acid (TA) in biphasic systems is reported, where Fe(III) and TA come into contact each other and self-assemble across the interface of two immiscible phases...
May 19, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28521994/double-coated-enrofloxacin-microparticles-with-chitosan-and-alginate-preparation-characterization-and-taste-masking-effect-study
#9
Mengxi Liu, Daiping Yin, Hualin Fu, Fengying Deng, Guangneng Peng, Gang Shu, Zhixiang Yuan, Fei Shi, Juchun Lin, Ling Zhao, Lizi Yin, Guoqing Fan
Enrofloxacin (ENRO) is widely used as an antimicrobial drug for treatment of uncomplicated and complicated infections in veterinary medicine. Its bitter taste limits its clinical applications in veterinary. To mask the bitter taste of this drug, double-coated taste-masking microparticles of ENRO (DTME) were prepared through stearic acid solid dispersion and chitosan-alginate microparticle coating technologies. The taste-masking effect was evaluated by pig feeding experiment. Results showed that DTME exhibited a spherical-like shape (170490μm)...
August 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28507467/preparation-and-characterization-of-beta-glucan-particles-containing-a-payload-of-nanoembedded-rifabutin-for-enhanced-targeted-delivery-to-macrophages
#10
Tarun K Upadhyay, Nida Fatima, Deepak Sharma, V Saravanakumar, Rolee Sharma
β-glucan particles (GP) are polymeric carbohydrates, mainly found as components of cell wall fungi, yeast, bacteria and also in cereals such as barley and oat, and have been recently shown to have application in macrophage-targeted drug delivery. The aim of this study was to prepare and characterize GP containing a large payload of Rifabutin (RB), an anti-tuberculosis drug effective against MDR-TB at lower MIC than Rifampicin. GP were prepared from yeast cells by acidic and alkaline extraction were either spray dried or lyophilized, prior to RB loading and alginate sealing...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28504171/tuneable-catechin-functionalisation-of-carbohydrate-polymers
#11
Susan Oliver, Aziidah Jofri, Donald S Thomas, Orazio Vittorio, Maria Kavallaris, Cyrille Boyer
In this contribution, we present a strategy to functionalise three natural carbohydrate polymers (dextran - a neutral polymer, sodium alginate - an anionic polymer and chitosan - a cationic polymer) with catechin with excellent degrees of functionality. In a first step, the carbohydrate polymers were oxidised by sodium periodate to yield aldehyde functionalised carbohydrate polymers. The presence of aldehyde groups was exploited to attach catechin by an acid catalysed nucleophilic reaction. The degree of catechin functionalisation could be easily tuned by varying the acid concentration in the reaction mixture, achieving catechin functionalisation levels of up to 48% for dextran aldehyde catechin, 35% for chitosan-aldehyde-catechin and 22% for sodium alginate aldehyde catechin...
August 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28490734/identification-and-activation-of-tlr4-mediated-signalling-pathways-by-alginate-derived-guluronate-oligosaccharide-in-raw264-7-macrophages
#12
Weishan Fang, Decheng Bi, Ruijin Zheng, Nan Cai, Hong Xu, Rui Zhou, Jun Lu, Min Wan, Xu Xu
Alginate, a natural acidic polysaccharide extracted from marine brown seaweeds, is composed of different blocks of β-(1, 4)-D-mannuronate (M) and its C-5 epimer α-(1, 4)-L-guluronate (G). Alginate-derived guluronate oligosaccharide (GOS) readily activates macrophages. However, to understand its role in immune responses, further studies are needed to characterize GOS transport and signalling. Our results show that GOS is recognized by and upregulates Toll-like receptor 4 (TLR4) on RAW264.7 macrophages, followed by its endocytosis via TLR4...
May 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28489424/a-novel-ph-responsive-hydrogel-based-on-calcium-alginate-engineered-by-the-previous-formation-of-polyelectrolyte-complexes-pecs-intended-to-vaginal-administration
#13
Natália Noronha Ferreira, Taciane Alvarenga Perez, Liliane Neves Pedreiro, Fabíola Garavello Prezotti, Fernanda Isadora Boni, Valéria Maria de Oliveira Cardoso, Tiago Venâncio, Maria Palmira Daflon Gremião
This work aimed to develop a calcium alginate hydrogel as a pH responsive delivery system for polymyxin B (PMX) sustained-release through the vaginal route. Two samples of sodium alginate from different suppliers were characterized. The molecular weight and M/G ratio determined were, approximately, 107 KDa and 1.93 for alginate_S and 32 KDa and 1.36 for alginate_V. Polymer rheological investigations were further performed through the preparation of hydrogels. Alginate_V was selected for subsequent incorporation of PMX due to the acquisition of pseudoplastic viscous system able to acquiring a differential structure in simulated vaginal microenvironment (pH 4...
May 10, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28486755/mechanical-stimulations-on-human-bone-marrow-mesenchymal-stem-cells-enhance-cells-differentiation-in-a-3d-layered-scaffold
#14
Jessica Schiavi, Loïc Reppel, Naceur Charif, Natalia de Isla, Didier Mainard, Nadia Benkirane-Jessel, Jean-François Stoltz, Rachid Rahouadj, Céline Huselstein
Scaffolds laden with stem cells are a promising approach for articular cartilage repair. Investigations have shown that implantation of artificial matrices, growth factors or chondrocytes can stimulate cartilage formation; but no existing strategy apply mechanical stimulation on stratified scaffolds to mimic the cartilage environment. The purpose of this study was to adapt a spraying method for stratified cartilage engineering and to stimulate the bio-substitute. Human Mesenchymal Stem Cells from Bone Marrow (BM-MSCs) were seeded in an Alginate/Hyaluronic Acid (Alg/HA) or Alg/Hydroxyapatite (Alg/Hap) gel to direct cartilage and hypertrophic cartilage/sub-chondral bone differentiation, respectively, in different layers linked with polyelectrolyte multilayer films, in a single scaffold...
May 9, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28482588/neuronal-production-from-induced-pluripotent-stem-cells-in-self-assembled-collagen-hyaluronic-acid-alginate-microgel-scaffolds-with-grafted-grgdsp-ln5-p4
#15
Yung-Chih Kuo, Cheng-Hong Hsueh
Self-assembled microgel functionalized with peptides was developed and applied to regenerate neurons from induced pluripotent stem cells (iPSCs). Collagen (COL), hyaluronic acid (HA), and alginate (ALG) were modified with methacrylic anhydride (MA), photocrosslinked for patterned particles, grafted with GRGDSP and Ln5-P4, and self-assembled to integrate the microgel into three-dimensional scaffolds. Physicochemical assessments revealed that the ternary microgel scaffolds had an optimal chemical composition at COLMA:HAMA:ALGMA=1:2:1...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28481253/drug-loadable-calcium-alginate-hydrogel-system-for-use-in-oral-bone-tissue-repair
#16
Luyuan Chen, Renze Shen, Satoshi Komasa, Yanxiang Xue, Bingyu Jin, Yepo Hou, Joji Okazaki, Jie Gao
This study developed a drug-loadable hydrogel system with high plasticity and favorable biological properties to enhance oral bone tissue regeneration. Hydrogels of different calcium alginate concentrations were prepared. Their swelling ratio, degradation time, and bovine serum albumin (BSA) release rate were measured. Human periodontal ligament cells (hPDLCs) and bone marrow stromal cells (BMSCs) were cultured with both calcium alginate hydrogels and polylactic acid (PLA), and then we examined the proliferation of cells...
May 6, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28464242/surface-functionalized-magnetic-nanoparticles-shift-cell-behavior-with-on-off-magnetic-fields
#17
Seongbeom Jeon, Ramesh Subbiah, Taufik Bonaedy, Seyoung VAN, Kwideok Park, Kyusik Yun
Magnetic nanoparticles (MNPs) are used as contrast agents and targeted drug delivery systems (TDDS) due to their favorable size, surface charge, and magnetic properties. Unfortunately, the toxicity associated with MNPs limits their biological applications. Surface functionalization of MNPs with selective polymers alters the surface chemistry to impart better biocompatibility. We report the preparation of surface functionalized MNPs using iron oxide NPs (MNPs), poly (lactic-co-glycolic acid) (PLGA) and sodium alginate via co-precipitation, emulsification, and electro-spraying, respectively...
May 2, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28458387/biodiesel-production-by-catalytic-esterification-of-oleic-acid-over-copper-ii-alginate-complexes
#18
Qiuyun Zhang, Fangfang Wei, Yutao Zhang, Fuhua Wei, Peihua Ma, Wei Zheng, Yongting Zhao, Hongliang Chen
A systematic study on copper (II)-alginate beads as catalysts for the synthesis of biodiesel via esterification of oleic acid and methanol is here reported for the first time. The chemical structure and morphologies of these catalysts were fully characterized by XRD, FT-IR, and SEM. The copper (II)-alginate beads showed a tubular structure with entangled reticulation. In the presence of copper (II)-alginate catalyst, the biodiesel conversion of 71.8% was achieved from oleic acid with methanol under the most mild conditions (1/10 oleic acid to methanol molar ratio, 250 mg catalyst, 70°C for 3 h), optimized by single-factor experiments...
2017: Journal of Oleo Science
https://www.readbyqxmd.com/read/28457462/characterization-of-methacrylated-alginate-and-acrylic-monomers-as-versatile-saps
#19
Arn Mignon, Jolien Vermeulen, Geert-Jan Graulus, José Martins, Peter Dubruel, Nele De Belie, Sandra Van Vlierberghe
Superabsorbent polymers (SAPs) based on polysaccharides, especially alginate, could offer a valuable solution in a plethora of applications going from drug delivery to self-healing concrete. This has already been proven with both calcium alginate and methacrylated alginate combined with acrylic acid. In this manuscript, the effect of varying the degree of methacrylation and use of a combination of acrylic acid and acrylamide is investigated to explore the effects on the relevant SAP characteristics. The materials showed high gel fractions and a strong swelling capacity up to 630gwater/gSAP, especially for superabsorbent polymers with a low degree of substitution...
July 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28457428/superabsorbent-hydrogel-made-of-naalg-g-poly-aa-co-aam-and-rice-husk-ash-synthesis-characterization-and-swelling-kinetic-studies
#20
Hamed Gharekhani, Ali Olad, Abdolreza Mirmohseni, Ahmad Bybordi
The sodium alginate-g-poly(acrylic acid-co-acrylamide)/rice husk ash (NaAlg-g-P(AA-co-AAm)/RHA) superabsorbent nanocomposite was synthesized by the free-radical graft copolymerization of alginate (NaAlg), acrylic acid (AA), acrylamide (AAm), and RHA in aqueous solution. FTIR spectra revealed that the monomers were grafted onto NaAlg chains, and the nanocomposite was formed successfully. Incorporation of RHA into hydrogel matrix formed porous interlinked channels within hydrogel network. Superabsorbent nanocomposite showed greater equilibrium swelling capacity (1070g/g) compared with neat hydrogel (830g/g)...
July 15, 2017: Carbohydrate Polymers
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