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Alginic acid

Sen Zhang, Yu Yang, Satoshi Takizawa, Li-An Hou
This study investigated the pretreatment effect of ferrihydrite (FH) on the removal of dissolved organic matter (DOM) and membrane fouling control in a hybrid adsorption-ultrafiltration (UF) membrane system. Powdered activated carbon (PAC) was chosen for comparative study, and three surrogates, namely, humic acid (HA), sodium alginate (SA) and bovine serum albumin, were applied in feed water to simulate humic substances, polysaccharides and proteins, respectively. In the hybrid adsorption-membrane system, the impacts of adsorbent cake layers on DOM removal and membrane fouling were systematically investigated...
March 10, 2018: Science of the Total Environment
Pengli Li, Jiejie Hao, Haihua Li, Huashi Guan, Chunxia Li
OBJECTIVES: Propylene glycol alginate sodium sulfate (PSS) is poorly absorbed by oral administration due to its large molecular weight and slightly degradability in stomach acidic environment. Here, a novel enteric-coated nano formulation of PSS (enteric PSS-NP) was prepared to improve its bioavailability and efficacy. METHODS: The enteric PSS-NP was prepared by double (W1 /O/W2 ) emulsion and solvent evaporation method. The drug release characteristics in vitro were studied in artificial gastrointestinal fluid...
March 12, 2018: Journal of Pharmacy and Pharmacology
Eun Jeong Lee, Ok Kyung Lee, Eun Yeol Lee
4-Deoxy-L-erythro-hexoseulose uronic acid (DEH) reductase is a key enzyme in alginate utilizing metabolism, but the number of characterized DEH reductase is quite limited. In this study, novel two DEH reductases, VsRed-1 and VsRed-2, were identified in marine bacterium Vibrio splendidus, and the recombinant enzymes were expressed in an Escherichia coli system and purified by Ni-NTA chromatography. The optimal pH and temperature of the recombinant VsRed-1 and VsRed-2 were pH 7.5, 30 °C, and pH 7.0, 35 °C, respectively...
March 13, 2018: Marine Biotechnology
Hisanori Iwai
Humic acid (HA) could become a useful agent for removing trace amounts of Cu(II) from contaminated seawater. This study reports on the use of a thin alginate membrane (TAM) containing immobilized HA as a Cu(II) binding agent for this purpose. The removal efficiency of Cu(II) by a TAM functionalized with HA was significantly increased compared to TAM alone. In this removal method, HA extracted from hardwood bark compost was more effective in removing Cu(II) than that from peat soil.
2018: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
Péter Veres, Dániel Sebők, Imre Dékány, Pavel Gurikov, Irina Smirnova, István Fábián, József Kalmár
Iron(III)-crosslinked alginate aerogel beads (d = 3-5 mm) were prepared and loaded with ibuprofen by using the technique of adsorptive deposition from supercritical CO2 . Additional formulations were prepared where the aerogels were co-impregnated by ibuprofen and ascorbic acid. The release of ibuprofen from the Fe(III)-alginate is much faster in pH = 7.4 (PBS) than in pH = 2.0 (HCl), which can be explained by the faster dissolution and higher swelling of the alginate matrix in PBS. By decreasing the size of the beads and using a higher G content alginate the release rate could be slightly increased...
May 15, 2018: Carbohydrate Polymers
Sandra Rojas-Moreno, Guillermo Osorio-Revilla, Tzayhrí Gallardo-Velázquez, Fernando Cárdenas-Bailón, Gabriela Meza-Márquez
Orange essential oil was microencapsulated by complex coacervation with whey protein isolate (WPI):carboxymethylcellulose (CMC), WPI:sodium alginate (SA) and WPI:chitosan (CH). Effect of pH, protein:polysaccharide ratio and solid concentration on coacervation efficiency were selected for the best coacervation conditions. Tannic acid, sodium tripolyphosphate, oxidized tannic acid and transglutaminase enzyme were used as cross-linking agents. Highest encapsulation efficiency (EE) for wet coacervated microcapsules ranged from 88-94%...
March 7, 2018: Journal of Microencapsulation
Insha Kousar Kalem, Z F Bhat, Sunil Kumar, Sabahu Noor, Ajay Desai
The aim of this study was to assess the effectiveness of calcium alginate edible films incorporated with Terminalia arjuna on the lipid oxidative stability and storage quality of chevon sausages. Chevon sausages were aerobically packaged in the edible films containing different concentrations of T. arjuna viz. T1 (0.0%), T2 (0.50%) and T3 (1.0%) and were stored under refrigerated (4±1 °C) conditions. A significant improvement was observed in the lipid oxidative stability and microbial quality of the products...
February 19, 2018: Meat Science
Trudy Christiansen-Weber, Alexander Noskov, Dylan Cardiff, Ibon Garitaonandia, Alexa Dillberger, Andrey Semechkin, Rodolfo Gonzalez, Russell Kern
Repair or regeneration of hyaline cartilage in knees, shoulders, intervertebral discs and other assorted joints is a major therapeutic target. To date, therapeutic strategies utilizing chondrocytes or mesenchymal stem cells are limited by expandability or the generation of mechanically inferior cartilage. Our objective is to generate robust cartilage-specific matrix from human mesenchymal stem cells suitable for further therapeutic development. Human mesenchymal stem cells, in an alginate 3D format, were supplied with individual sugars and chains which comprise the glycan component of proteoglycans in articular cartilage (galactose, hyaluronic acid, glucuronic acid and xylose) during chondrogenesis...
February 28, 2018: Journal of Tissue Engineering and Regenerative Medicine
Shuang Zhao, Longyue Shi, Yu Ma, Zhan Wang
In order to find a model solution to simulate actual extracellular polymeric substances (EPS) solution in terms of filterability behavior, a series of experiments were conducted in a dead-end unstirred cell with 0.1 μm polyvinylidene fluoride membranes using binary/ternary mixtures consisting of sodium alginate (SA), bovine serum albumin (BSA) and humic acid (HA). Three target parameters (cumulative filtrate volume (CFV), specific cake resistance (αc ) and rejection (R)) were compared and the roles of mixture components were investigated...
February 2018: Water Science and Technology: a Journal of the International Association on Water Pollution Research
Mari Matoba, Toshitaka Takagi, Hiroyuki Tsujimoto, Yuki Ozamoto, Jo Ueda, Akeo Hagiwara
Postoperative air leaks remain a major cause of morbidity after lung resection. This study evaluated the effect of a combination of polyglycolic acid (PGA) sheet and alginate gel on pulmonary air leaks in rats. Four pulmonary sealing materials were evaluated in lung injury: fibrin glue, combination of PGA sheet and fibrin glue, alginate gel, and combination of PGA sheet and alginate gel. With the airway pressure maintained at 20 cmH2 O, a 2 mm deep puncture wound was created on the lung surface using a needle...
2018: BioMed Research International
Zi-Jian Shao, Xue-Lian Huang, Fan Yang, Wei-Feng Zhao, Xin-Zhi Zhou, Chang-Sheng Zhao
Sodium alginate (SA) beads with ultrahigh adsorption capacity were prepared via hydrogen bonds between SA and 2-acrylamido-2-methylpropa-1-propanesulfonic acid (AMPS), and the AMPS was then post-cross-linked to manufacture SA/PAMPS beads. The equilibrium adsorption capacities of methylene blue (MB) and Pb2+ for the SA/PAMPS10 beads were 2977 and 2042 mg/g, respectively. Although the SA beads exhibited higher equilibrium adsorption capacities of MB and Pb2+ than those of the SA/PAMPS10 beads, the SA/PAMPS10 beads had better mechanical property and higher stability...
May 1, 2018: Carbohydrate Polymers
João C Boga, Sónia P Miguel, Duarte de Melo-Diogo, António G Mendonça, Ricardo O Louro, Ilídio J Correia
The incidence of fractures and bone-related diseases like osteoporosis has been increasing due to aging of the world's population. Up to now, grafts and titanium implants have been the principal therapeutic approaches used for bone repair/regeneration. However, these types of treatment have several shortcomings, like limited availability, risk of donor-to-recipient infection and tissue morbidity. To overcome these handicaps, new 3D templates, capable of replicating the features of the native tissue, are currently being developed by researchers from the area of tissue engineering...
February 21, 2018: Colloids and Surfaces. B, Biointerfaces
K X Xie, Y G Li, P Zhang, X Wang
OBJECTIVE: To evaluate the effect of acid etching of retropreps on seal of different retrofill materials. METHODS: In the study, 80 freshly extracted lower molar teeth were used. They were examined under 3.5× magnifying glass to rull out fractures. They were cleaned and stored in distilled water before use. The distal roots were sectioned off and underwent root canal treatment. Rotary nickel-titanium instruments were used during instrumentation and the roots were obturated using lateral condensation technique...
February 18, 2018: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
Seyed Ramin Pajoumshariati, Morteza Azizi, Daniel Wesner, Paula G Miller, Michael Shuler, Alireza Abbaspourrad
Microfluidic-based cell encapsulation has promising potential in therapeutic applications. It also provides a unique approach for studying cellular dynamics and interactions, though this concept has not yet been fully explored. No in vitro model currently exists that allows us to study the interaction between crypt cells and Peyer's patch immune cells due to the difficulty in recreating with sufficient control the two different microenvironments in the intestine in which these cell types belong. However, we demonstrate that our microfluidic technique is able to provide such precise control and that these cells can proliferate inside the microgels...
February 23, 2018: ACS Applied Materials & Interfaces
Jiqing Yang, Xiaotong Hu, Jia Xu, Xin Liu, Li Yang
A novel capillary electrophoresis-integrated immobilized enzyme reactor (CE-integrated IMER) is developed using single-step in-situ acetylcholinesterase (AChE)-mediated alginate hydrogelation and enzyme encapsulation. Alginate hydrogelation with "egg-box" structure is triggered inside a capillary with releasing of Ca2+ by changing the pH of the sol solution, which is accomplished in-situ by AChE-catalyzed hydrolysis reaction of acetylthiocholine to produce acetic acid. AChE and any other enzyme initially contained in the sol solution [e...
February 22, 2018: Analytical Chemistry
Jasmina Stojkovska, Zeljka Djurdjevic, Ivan Jancic, Biljana Bufan, Marina Milenkovic, Radmila Jankovic, Vesna Miskovic-Stankovic, Bojana Obradovic
In the present study, possibilities for using novel nanocomposites based on alginate and silver nanoparticles for wound treatment were investigated in a second-degree thermal burn model in Wistar rats. Silver nanoparticles (AgNPs) were electrochemically synthesized in alginate solutions that were further utilized to obtain the Ag/alginate solution and microfibers for subsequent in vivo studies. Daily applications of the Ag/alginate colloid solution, containing AgNPs, alginate and ascorbic acid (G3), wet Ag/alginate microfibers containing AgNPs (G5) and dry Ag/alginate microfibers containing AgNPs (G6) were compared to treatments with a commercial cream containing silver sulfadiazine (G2) and a commercial Ca-alginate wound dressing containing silver ions (G4), as well as to the untreated controls (G1)...
January 1, 2018: Journal of Biomaterials Applications
Pingyun Yuan, Xinyu Qiu, Ronghua Jin, Yongkang Bai, Shiyu Liu, Xin Chen
Herein, we reveal a double emulsion method combining the sol-gel method to prepare poly(lactic-co-glycolic acid) microspheres with different porous structures for sequential release of two types of biomolecules. By controlling the ripening time of the emulsion, multiple interconnected chambers could be easily chosen to be either embedded in microspheres or opened to the surface. These two types of microspheres exhibited different kinetics for the release of both small molecules and proteins, where the release from microspheres with open pores (5 day over 90%) was much faster than the release from microspheres with embedded pores (25 day over 90%)...
February 20, 2018: Biomaterials Science
Sabahu Noor, Z F Bhat, Sunil Kumar, Reshan J Mudiyanselage
Asparagus racemosus was used as a bioactive ingredient for the development of a novel calcium alginate edible film with preservative potential for improved lipid oxidative stability and storage quality of meat products. Chevon sausages were used as a model system and were aerobically packaged in the edible films incorporated with A. racemosus viz. T0 (0.0%), T1 (1.0%) and T2 (2.0%) and were stored under refrigerated (4 ± 1 °C) conditions. Products packaged in T1 and T2 edible films exhibited significantly (P < 0...
February 2, 2018: Meat Science
Fu-Chen Kung
Imbalance crosslink density and polymer concentration gradient is formed within the traditional alginate hydrogel using calcium chloride as a crosslinking agent in external gelation for instantaneously process. In this studying, type I collagen (Col I) blended calcium salt form of poly(γ-glutamic acid) (γCaPGA) was mixing with RGD-modified alginate with convenient gelation process and suitable for practical use. The hydrophilicity of the resulting hydrogels was evaluated through swelling tests, water retention capacity tests, and water vapor permeation tests...
2018: Bio-medical Materials and Engineering
Anita Krouwels, Ferry Melchels, Mattie H P Van Rijen, F Cumhur Oner, Wouter Dhert, M Tryfonidou, Laura Creemers
Hydrogels can facilitate nucleus pulposus regeneration, either for clinical application or research into mechanisms of regeneration. However, many different hydrogels and culture conditions for human degenerated nucleus pulposus (NP) have been employed, making literature data difficult to compare. Therefore, we compared six different hydrogels of natural polymers and investigated the role of serum in the medium and of osmolarity during expansion or redifferentation in an attempt to provide comparators for future studies...
February 17, 2018: Tissue Engineering. Part C, Methods
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