keyword
MENU ▼
Read by QxMD icon Read
search

Soft tissue sarcoma extremity

keyword
https://www.readbyqxmd.com/read/29346043/analysis-of-margin-classification-systems-for-assessing-the-risk-of-local-recurrence-after-soft-tissue-sarcoma-resection
#1
Kenneth R Gundle, Lisa Kafchinski, Sanjay Gupta, Anthony M Griffin, Brendan C Dickson, Peter W Chung, Charles N Catton, Brian O'Sullivan, Jay S Wunder, Peter C Ferguson
Purpose To compare the ability of margin classification systems to determine local recurrence (LR) risk after soft tissue sarcoma (STS) resection. Methods Two thousand two hundred seventeen patients with nonmetastatic extremity and truncal STS treated with surgical resection and multidisciplinary consideration of perioperative radiotherapy were retrospectively reviewed. Margins were coded by residual tumor (R) classification (in which microscopic tumor at inked margin defines R1), the R+1mm classification (in which microscopic tumor within 1 mm of ink defines R1), and the Toronto Margin Context Classification (TMCC; in which positive margins are separated into planned close but positive at critical structures, positive after whoops re-excision, and inadvertent positive margins)...
January 18, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29325767/primary-synovial-sarcoma-arising-from-gingivo-buccal-sulcus-harbouring-ss18-ssx2-positive-fusion-transcript-the-1st-reported-case-in-english-literature
#2
Tanush Vig, Meera Thomas, Rekha Pai, Amit Jiwan Tirkey, Rajnikanth Janakiraman
Synovial sarcoma (SS) is a mesenchymal tumour of uncertain histiogenesis that can show dual epithelial and mesenchymal differentiation. Thought to arise predominantly in deep soft tissue of extremities, these sarcomas have shown that they can affect a wide variety of organs and sites, however intraoral mucosal SS is rarely encountered and herein the authors present possibly the second reported case of a young lady presenting with a slow growing tumour arising in the gingivo-buccal sulcus that was reported as Synovial sarcoma on biopsy and subsequently confirmed using molecular studies, tumour demonstrating SS18-SSX2 fusion transcript...
January 8, 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29323080/recurrent-leiomyosarcoma-scrotum-an-important-differential-in-scrotal-masses
#3
Ranjan Agrawal, Miti Gupta, Nitesh Mohan, Jagdamba Sharan, Parbodh Kumar
Soft tissue sarcomas of the genitourinary tract are rare. Paratesticular sarcomas are extremely rare with majority of scrotal masses localizing to the testis and being neoplastic in nature. Paratesticular leiomyosarcomas (LMSs) are located in the spermatic cord, epididymis, or scrotum. However, their location in the scrotal skin or subcutaneous tissue is extremely rare. Only 10 cases have been reported from India previously. Ours is the 11th case. A 50-year-old male presented with a recurrent scrotal mass which was painless and gradually increasing in size...
October 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29315173/factors-associated-with-acute-and-chronic-wound-complications-in-patients-with-soft-tissue-sarcoma-with-long-term-follow-up
#4
Naveen Karthik, Matthew C Ward, Aditya Juloori, Jacob Scott, Nathan Mesko, Chirag Shah
OBJECTIVES: To identify the rates of acute and chronic wound complications and factors associated in a cohort of patients treated for soft tissue sarcoma (STS) with modern radiotherapy (RT) and surgical techniques. MATERIALS AND METHODS: An Institutional Review Board-approved database was used to identify all adult nonmetastatic patients treated for STS at a single institution between 2006 and 2015 with a minimum follow-up of 1 year. Factors associated with acute and chronic wound complications were analyzed using binomial logistic regression including interaction terms...
January 8, 2018: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29309807/solitary-fibrous-tumor-with-neuroendocrine-and-squamous-dedifferentiation-a-potential-diagnostic-pitfall
#5
Chuanyong Lu, Deepu Alex, Ryma Benayed, Marc K Rosenblum, Meera R Hameed
Solitary fibrous tumor (SFT) is a ubiquitous mesenchymal neoplasm of deep soft tissue with variable and often unpredictable biological behavior. The lineage is presumed to be fibroblastic and histological features range from benign to overtly malignant with rare tumors showing "dedifferentiation" or transformation to undifferentiated pleomorphic sarcoma. Dedifferentiation in mesenchymal neoplasms is a phenomenon of histologic progression of a well-differentiated neoplasm to a high-grade sarcoma which can differentiate along divergent lines...
January 5, 2018: Human Pathology
https://www.readbyqxmd.com/read/29308306/analysis-of-the-immune-infiltrate-in-undifferentiated-pleomorphic-sarcoma-of-the-extremity-and-trunk-in-response-to-radiotherapy-rationale-for-combination-neoadjuvant-immune-checkpoint-inhibition-and-radiotherapy
#6
Emily Z Keung, Jen-Wei Tsai, Ali M Ali, Janice N Cormier, Andrew J Bishop, B Ashleigh Guadagnolo, Keila E Torres, Neeta Somaiah, Kelly K Hunt, Jennifer A Wargo, Alexander J Lazar, Wei-Lien Wang, Christina L Roland
Background: Undifferentiated pleomorphic sarcoma of the extremity and trunk (ET-UPS) presents a unique therapeutic challenge. Although immunotherapy has recently been employed in advanced soft tissue sarcoma, there is limited data characterizing the immune infiltrate in ET-UPS. Radiotherapy (RT) has been shown in other tumor types to promote tumor antigen release and enhance tumor-specific targeting by the adaptive immune system. The aim of this study was to 1) characterize the baseline immune infiltrate and 2) evaluate the effect of preoperative RT on the histologic appearance of and the immune infiltrate in ET-UPS...
2018: Oncoimmunology
https://www.readbyqxmd.com/read/29302306/alveolar-soft-part-sarcoma-of-flexure-tendon
#7
Chatchai Pruksapong, Kantang Satayasoontorn
Alveolar soft part sarcoma (ASPS) is a very rare sarcoma, report <1% of all soft tissue tumor. Majority of cases were young adult and tumor occurred in lower extremities and trunk. Here, we present a case of 53-year-old Thai female with rapidly glowing mass over her right forearm. The magnetic resonance imaging scan demonstrated a hypervascular mass with multiple feeding vessels located in flexure tendon of right forearm. Ultrasound-guided biopsy revealed malignant poorly differentiated epithelioid neoplasm with clear cell feature and focal necrosis...
December 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29283939/rabdomyosarcoma-of-the-mandible-an-uncommon-clinical-presentation
#8
Cleverton Roberto de Andrade, Guilherme Dos Santos Trento, Fabiano Jeremias, Elisa Maria Aparecida Giro, Marisa Aparecida Cabrini Gabrielli, Mario Francisco Real Gabrielli, Oslei Paes de Almeida, Valfrido Antonio Pereira-Filho
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and adolescents. Most patients present with a mass in the head and neck region, urogenital region, or with distal extremity involvement. The authors describe a challenging case of a 6-year-old male patient presenting with mandibular RMS. The clinical/radiographic/tomographic evaluations classified the tumor as an advanced stage (stage IV), with a mass of 6.0 cm involving the left side of the mandible and parotid region. The biopsy revealed round, spindled, and pleomorphic cells with hyperchromatic nuclei and rare larger rhabdomyoblasts with eosinophilic cytoplasm...
December 27, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29275911/flap-reconstruction-does-not-increase-complication-rates-following-surgical-resection-of-extremity-soft-tissue-sarcoma
#9
Jelena Slump, Stefan O P Hofer, Peter C Ferguson, Jay S Wunder, Anthony M Griffin, Harald J Hoekstra, Esther Bastiaannet, Anne C O'Neill
BACKGROUND: Flap reconstruction plays an essential role in the surgical management of extremity soft tissue sarcoma (ESTS) for many patients. But flaps increase the duration and complexity of the surgery and their contribution to overall morbidity is unclear. This study directly compares the complication rates in patients with ESTS undergoing either flap reconstruction or primary wound closure and explores contributing factors. METHODS: Eight hundred and ninety-seven patients who underwent ESTS resection followed by primary closure (631) or flap reconstruction (266) were included in this study...
November 26, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29274042/sclerosing-epithelioid-fibrosarcoma-of-the-jaw-late-recurrence-from-a-low-grade-fibromyxoid-sarcoma
#10
Catherine Laliberte, Iona T Leong, Howard Holmes, Eric A Monteiro, Brian O'Sullivan, Brendan C Dickson
Sclerosing epithelioid fibrosarcoma (SEF) is an uncommon variant of fibrosarcoma that is characterized by a distinct morphology. It most frequently presents in the deep soft tissues of the lower extremities, often in intimate association with fascia and periosteum, although reports of the head and neck involvement have been reported. A minority of cases show morphological, immunohistochemical and molecular overlap with low grade fibromyxoid sarcoma (LG-FMS). Herein, we describe a case of a bland spindle cell neoplasm presenting in the jaw that was initially incompletely excised...
December 22, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/29259650/cytologic-features-of-primary-monophasic-synovial-sarcoma-of-the-thyroid-gland
#11
Chang-Soo Park, Young Kim, Eun-Hui Jeong, Nah-Ihm Kim, Yoo-Duk Choi
Synovial sarcoma (SS) is a rare soft tissue tumor, commonly arising in para-articular areas of extremities, but can also present in the head and neck area. However, primary SS of the thyroid gland is an extremely rare tumor which has been reported only five times in previous English literatures. This report presents fine needle aspiration (FNA) cytology of primary monophasic SS of the thyroid gland. A 47-year- old woman incidentally detected thyroid nodule in the isthmus of right thyroid gland on an ultrasonography by regular health check-up...
2017: CytoJournal
https://www.readbyqxmd.com/read/29234656/amputation-risk-after-the-revascularization-procedures-in-sarcoma-resections
#12
Luiz Eduardo Moreira Teixeira, Thiago Marques Leão, Daniel Barbosa Regazzi, Cláudio Beling Gonçalves Soares
Objective: The objective of this study is to evaluate the efficacy of vascular reconstructive surgery after resection of bone and soft tissue tumors in extremities and the risk of progression to amputation. Methods: This is a retrospective, observational data collection from medical records of patients who underwent resection of bone and soft tissue tumors in the period of 2002-2015. Thirteen patients met the inclusion criteria, which evaluated the correlations between certain factors (gender, tumor type, location, reconstruction, revascularization and patency, infection) with amputation in the postoperative period...
November 2017: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/29228461/imaging-of-liposarcomas-for-clinicians-characteristic-features-and-differential-considerations
#13
REVIEW
Oluwadamilola Teniola, Kevin Yuqi Wang, Wei-Lien Wang, WilliamW Tseng, Behrang Amini
Liposarcoma (LPS) is a malignancy of fat and one of the most common soft tissue sarcomas. There are three major subtypes of LPS: Well-differentiated / dedifferentiated, myxoid, and pleomorphic. We review the imaging features of LPS in the abdomen and extremities, describe features that help differentiate the subtypes, and provides alternative considerations for fat-containing lesions (many benign) that can mimic LPS.
December 11, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29220299/perioperative-management-of-extremity-soft-tissue-sarcomas
#14
Rick L Haas, Alessandro Gronchi, Michiel A J van de Sande, Elizabeth H Baldini, Hans Gelderblom, Christina Messiou, Eva Wardelmann, Axel Le Cesne
Surgery is potentially curative for primary nonmetastatic extremity soft tissue sarcomas. After surgery alone, patients may remain at risk for local recurrences and/or metastatic disease. To reduce the likelihood of a local relapse, the addition of radiotherapy (RT) to limb-sparing surgery may result in higher local control rates of at least 85%. Generally, it can be stated that local control after both preoperative and postoperative RT is comparable, but that preoperative RT comes with a more favorable toxicity profile after prolonged follow-up, albeit at the cost of a higher wound complication rate...
December 8, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29220297/local-control-of-soft-tissue-and-bone-sarcomas
#15
Joseph G Crompton, Koichi Ogura, Nicholas M Bernthal, Akira Kawai, Fritz C Eilber
Sarcomas of soft tissue and bone are mesenchymal malignancies that can arise in any anatomic location, most commonly the extremity, retroperitoneum, and trunk. Even for lower grade histologic subtypes, local recurrence can cause significant morbidity and even disease-related death. Although surgery remains the cornerstone of local control, perioperative radiation and systemic therapy are often important adjuvants. This review will summarize the current therapeutic approaches for local control of soft tissue and bone sarcomas...
December 8, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29212731/clinical-activity-of-pazopanib-in-patients-with-advanced-desmoplastic-small-round-cell-tumor
#16
Brian A Menegaz, Branko Cuglievan, Jalen Benson, Pamela Camacho, Salah-Eddine Lamhamedi-Cherradi, Cheuk Hong Leung, Carla L Warneke, Winston Huh, Vivek Subbiah, Robert S Benjamin, Shreyaskumar Patel, Najat Daw, Andrea Hayes-Jordan, Joseph A Ludwig
BACKGROUND: Desmoplastic small round cell tumor (DSRCT) is an aggressive, often fatal soft tissue sarcoma that lacks an optimal salvage regimen. We retrospectively reviewed data from 29 pretreated DSRCT patients who received pazopanib at MD Anderson Cancer Center after failure of standard chemotherapies. SUBJECTS, MATERIALS, AND METHODS: Medical records of patients treated from January 2012 to December 2016 were reviewed and regression analyses were performed. Median progression-free survival (PFS) and overall survival (OS) were estimated using the Kaplan-Meier method and differences in survival were assessed by a log-rank test...
December 6, 2017: Oncologist
https://www.readbyqxmd.com/read/29209518/diagnosis-and-treatment-of-soft-tissue-sarcomas-of-the-extremities-and-trunk
#17
Maria Anna Smolle, Dimosthenis Andreou, Per-Ulf Tunn, Joanna Szkandera, Bernadette Liegl-Atzwanger, Andreas Leithner
The relatively low incidence and often atypical clinical presentation of soft-tissue sarcomas (STS) impedes early and adequate diagnosis. Patients may report on recently enlarged soft-tissue swellings, infrequently complain of painful lesions, or even have no symptoms at all.A thorough diagnostic work-up is essential in order to distinguish between benign soft-tissue tumours and STSs. Patient history, clinical features and radiological findings all help in assessing the underlying pathology. 'Worrying' features such as recent increase in size, deep location relative to the fascia, a tumour exceeding 4 cm in size, and invasive growth patterns seen on imaging should prompt verification by biopsy...
October 2017: EFORT Open Reviews
https://www.readbyqxmd.com/read/29208319/defining-the-incidence-and-clinical-significance-of-lymph-node-metastasis-in-soft-tissue-sarcoma
#18
Emily Z Keung, Yi-Ju Chiang, Rachel K Voss, Janice N Cormier, Keila E Torres, Kelly K Hunt, Barry W Feig, Christina L Roland
INTRODUCTION: The incidence and clinical significance of lymph node metastasis (LNM, N1) in soft tissue sarcoma (STS) is unclear. Recent studies have focused on extremity/trunk STS (ETSTS). We sought to define the subgroup of patients with LNM at sarcoma diagnosis across all disease sites and histologies. METHODS: We identified and categorized 89,870 STS patients from the National Cancer Data Base (1998-2012) by nodal stage. Pathologically confirmed LNM (pN1) were identified in 1404 patients; 1750 had clinically suspicious but not pathologically confirmed LNM (cN1)...
November 27, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29205902/therapeutic-options-and-postoperative-wound-complications-after-extremity-soft-tissue-sarcoma-resection-and-postoperative-external-beam-radiotherapy
#19
Mohamed H Abouarab, Iman L Salem, Magdy M Degheidy, Dominic Henn, Christoph Hirche, Ahmad Eweida, Matthias Uhl, Ulrich Kneser, Thomas Kremer
Soft tissue sarcomas occur most commonly in the lower and upper extremities. The standard treatment is limb salvage surgery combined with radiotherapy. Postoperative radiotherapy is associated with wound complications. This systematic review aims to summarise the available evidence and review the literature of the last 10 years regarding postoperative wound complications in patients who had limb salvage surgical excision followed by direct closure vs flap coverage together with postoperative radiotherapy and to define the optimal timeframe for adjuvant radiotherapy after soft tissue sarcomas resection and flap reconstruction...
December 5, 2017: International Wound Journal
https://www.readbyqxmd.com/read/29202999/epithelioid-sarcoma-of-the-plantar-fascia-mimicking-morbus-ledderhose-a-severe-pitfall-for-clinical-and-histopathological-misinterpretation
#20
Andreas Toepfer, Norbert Harrasser, Florian Dreyer, Carolin Mogler, Markus Walther, Rüdiger von Eisenhart-Rothe
Plantar fibromatosis, also known as Morbus Ledderhose, is a well known and frequently encountered disorder of the planta pedis. When conservative treatment fails, surgical therapy with complete resection is the therapeutical procedure of choice. Soft tissue sarcoma is a heterogeneous and rare malignant disease of the musculoskeletal system with over 50 histopathological subtypes which can potentially arise in any localization but is most commonly found at the extremities. Here, we report the case of an epithelioid sarcoma of the sole of the foot which was initially and repeatedly clinically and histopathologically misinterpreted as plantar fibromatosis, receiving insufficient resection and subsequently ending in amputation of the lower leg...
December 2017: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
keyword
keyword
25705
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"