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Soft tissue sarcoma extremity

Petra Balogh, Rita Bánusz, Monika Csóka, Zsófia Váradi, Edit Varga, Zoltán Sápi
BACKGROUND: Rhabdomyosarcoma (RMS) is a malignant tumor of mesenchymal origin and comprises the largest category of soft-tissue sarcomas both in children and adolescents. From a pediatric oncology point of view, RMS has traditionally been classified into alveolar (ARMS) and embryonal (ERMS) subtypes. The anatomical localization of the tumor may vary, but commonly involve the head/neck regions, male and female urogenital tract or the trunk and extremities. CASE PRESENTATION: Here, we report two challenging cases involving 17- and 9-years-olds males where diffuse and multiplex bone lesions suggested either a hematological disease or a primary bone tumor (mesenchymal chondrosarcoma)...
October 18, 2016: Diagnostic Pathology
Fien Hoefkens, Charlotte Dehandschutter, Johan Somville, Paul Meijnders, Dirk Van Gestel
Soft tissue sarcomas are uncommon tumours of mesenchymal origin, most commonly arising in the extremities. Treatment includes surgical resection in combination with radiotherapy. Resection margins are of paramount importance in surgical treatment of soft tissue sarcomas but unambiguous guidelines for ideal margins of resection are still missing as is an uniform guideline on the use of radiotherapy.The present paper reviews the literature on soft tissue sarcomas of the extremities regarding the required resection margins, the impact of new radiotherapy techniques and the timing of radiotherapy, more particularly if it should be administered before or after surgical resection...
October 12, 2016: Radiation Oncology
Anna M Stagner, Frederick A Jakobiec, Aaron Fay
Synovial sarcoma (SS) is a soft tissue sarcoma of the extremities developing in young adults that has rarely been reported in the orbit. SS is associated with a unique translocation, resulting in an SYT-SSX fusion gene. We analyze seven published periocular cases, together with the current one, to gain a better appreciation of the features of the tumor in this location and to compare the findings with those derived from non-ophthalmic studies. A 31-year-old woman developed an inferior orbital mass after experiencing periorbital and hemifacial pain for more than a decade...
September 30, 2016: Survey of Ophthalmology
Laura A Davis, Firas Dandachli, Robert Turcotte, Oren K Steinmetz
BACKGROUND: The standard of care for lower extremity soft tissue sarcoma (STS) is limb-sparing surgery. A small subset of these patients will require concomitant vascular reconstruction to ensure adequate resection and to preserve limb viability and function. The aim of this study was to evaluate outcomes in these patients with respect to wound healing and postoperative functional status. METHODS: Outcomes for a total of 154 patients treated for malignant lower extremity STS during an 8-year period between 2005 and 2013 were entered in a prospective registry...
September 26, 2016: Journal of Vascular Surgery
Safina Ahmed, Shoaib Naiyar Hashmi
OBJECTIVE: To determine friend leukaemia integration 1 transcription factor protein expression in cases of Ewing sarcoma. METHODS: This retrospective, descriptive study was conducted at the Armed Forces Institute of Pathology, Rawalpindi, Pakistan, and comprised data of diagnosed cases of Ewing sarcoma related to the period from February 2013 to December 2014. Clinico-pathological features, including patient age, gender and site of biopsy were studied. Positivity of immunohistochemical markers such as cluster of differentiation 99(membranous staining) and Friend leukaemia integration 1 transcription factor (nuclear staining) were noted...
October 2016: JPMA. the Journal of the Pakistan Medical Association
N Sen, M Batus, E B Jeans, L Miller, S Gitelis, D Wang, R A Abrams
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
M H Robinson, P Gaunt, R Grimer, B Seddon, J Wylie, A Davis, D Hughes, D Peake, A Cassoni, D Spooner, A Miah, A Hughes, C M L West, K Venables, L Billingham
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Naoko Ishiguro, Haruhiko Yoshida
Alveolar soft part sarcoma is an extremely rare soft tissue sarcoma with poor prognosis. It is characterized by the unbalanced recurrent chromosomal translocation der(17)t(X;17)(p11;q25), resulting in the generation of an ASPL-TFE3 fusion gene. ASPL-TFE3 oncoprotein functions as an aberrant transcriptional factor and is considered to play a crucial role in the tumorigenesis of alveolar soft part sarcoma. However, the underlying molecular mechanisms are poorly understood. In this study, we identified p21 (p21(WAF1/CIP1)) as a direct transcriptional target of ASPL-TFE3...
October 2016: Neoplasia: An International Journal for Oncology Research
K Ghazikhanlou-Sani, S M P Firoozabadi, L Agha-Ghazvini, H Mahmoodzadeh
INTRODUCTION: There is many ways to assessing the electrical conductivity anisotropy of a tumor. Applying the values of tissue electrical conductivity anisotropy is crucial in numerical modeling of the electric and thermal field distribution in electroporation treatments. This study aims to calculate the tissues electrical conductivity anisotropy in patients with sarcoma tumors using diffusion tensor imaging technique. MATERIALS AND METHOD: A total of 3 subjects were involved in this study...
June 2016: Journal of Biomedical Physics & Engineering
Bill Pass, Maria Johnson, Elizabeth M A Hensor, Harun Gupta, Philip Robinson
OBJECTIVES: To evaluate quantitative sonoelastography of benign and malignant musculoskeletal soft tissue masses. METHODS: We conducted a prospective study of 50 patients from a specialist sarcoma center who had extremity soft tissue masses referred for biopsy. After consent, the quantitative shear wave velocity (meters per second) was measured in longitudinal and transverse planes (3 readings in each plane and mean calculated). All masses subsequently underwent biopsy, excision, or both, with the histologic diagnosis taken as the reference standard...
October 2016: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
Deepak Chandrasekaran, Kathiresan Narayanaswamy, Shirley Sundersingh, Karthikeyan Senniappan, Anand Raja
Synovial sarcomas occurs primarily in the soft tissues, mostly in para-articular regions of the extremities. These tumors have been described in other unusual locations like the pleura, lungs, mediastinum, and kidneys. Primary synovial sarcoma of the kidney is a recently described entity; to date, a total of approximately 35 cases have been reported. Only three cases of primary synovial sarcoma of kidney with IVC thrombus have been reported so far. Here we present the case of a 44 year old gentleman, with primary synovial sarcoma of the left kidney with caval thrombus...
September 2016: Indian Journal of Surgical Oncology
N H Alotaibi, Aurélie Bornand, Nicolas Dulguerov, M Becker, Pavel Dulguerov
INTRODUCTION: Synovial sarcoma (SS) is uncommon high grade soft tissue sarcoma, accounting for less than 10% of all head and neck sarcomas. Also, about 10% of SS occur within the Head & Neck. In the pediatric population, SS is an extremely rare head & neck malignancy. PRESENTATION OF CASE: We present a case of sixteen years old boy diagnosed with SS situated of the hypopharynx treated by surgical excision and post operative radio-chemotherapy. DISCUSSION: This anatomical location brings additional functional challenges (swallowing, phonation, respiration), especially in the pediatric population...
September 3, 2016: International Journal of Surgery Case Reports
Ghadah Al Sannaa, Kelsey L Watson, Adriana Olar, Wei-Lien Wang, Gregory N Fuller, Ian McCutcheon, Keila E Torres, Alexander J Lazar
BACKGROUND: Brain metastasis from sarcoma is rare, thus limited information is available. We examined sarcoma brain metastases diagnosed at our institution over a period of 28 years. METHODS: This is a retrospective study of 112 cases. Clinical records were reviewed and clinical, pathological, and survival data were tabulated. RESULTS: Undifferentiated sarcoma was the most common source. In 50 % of cases, the primary sarcoma was in the extremities...
September 19, 2016: Annals of Surgical Oncology
Khin Thway, Dirk C Strauss, Dorte Wren, Cyril Fisher
Angiomatoid fibrous histiocytoma (AFH) is a soft tissue tumor of intermediate biologic potential and uncertain differentiation that most frequently occurs in the superficial extremities of children and young adults. It is histologically typified by nodules of ovoid to spindle cells with pseudoangiomatoid spaces and a surrounding dense lymphoplasmacytic infiltrate, desmin expression in about 50%, and association with EWSR1-CREB1, EWSR1-ATF1 or FUS-ATF1 gene fusions. The diagnosis still poses a challenge because AFH may not display all classic features, can show a variety of unusual histologic findings and lacks a specific immunoprofile...
September 3, 2016: Pathology, Research and Practice
Darin Davidson, Ronald D Barr, Soha Riad, Anthony M Griffin, Peter W Chung, Charles N Catton, Brian O'Sullivan, Peter C Ferguson, Aileen M Davis, Jay S Wunder
BACKGROUND AND OBJECTIVES: The primary objective of this study was to estimate the change in health-related quality of life (HRQL) 1 year following treatment for extremity soft tissue sarcoma (STS), measured by the EQ-5D. Secondary objectives included determining clinical variables associated with HRQL at 1 year, estimating the proportion with a clinically important difference (CID) in HRQL, and evaluating variability within EQ-5D domains. METHODS: Patients over the age of 16 years, treated for a localized extremity STS, were included...
September 16, 2016: Journal of Surgical Oncology
Yeon Joo Kim, Si Yeol Song, Wonsik Choi, Hyoung Uk Je, Jin-Hee Ahn, Hye Won Chung, Jong-Seok Lee
BACKGROUND: Soft-tissue sarcomas (STS) of the distal extremities are a rare disease entity, hence proper treatment strategy is not well established. We evaluated the local control, survival and complications of treating sarcomas in the wrist, hand, ankle and foot with limb-sparing surgery (LSS) and postoperative radiotherapy (PORT). PATIENTS AND METHODS: Seventeen patients with STS in wrist, hand, ankle and foot who received PORT after LSS from August 2008 to November 2015 were retrospectively reviewed...
September 2016: Anticancer Research
C Llacer-Moscardo, C Bourgier, A Morel, P Fenoglietto, S Carrère, N Firmin, D Azria
The standard treatment for extremity soft tissue sarcomas is based on the association of surgery and radiotherapy. This strategy allows local control improvement with the risk of increased toxicity. There is therefore a growing interest to identify those patients who will benefit from radiotherapy and those who will have the same local control with surgery alone. Furthermore, the development of toxicity has been correlated with the extension of the irradiated volume and the volume receiving high doses. Technological development as intensity modulated radiotherapy and image-guided radiotherapy allows limited irradiated volume improving the protection of the organs at risk leading to clinical benefit improvement...
October 2016: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
A Ducassou, C Haie-Méder, M Delannes
The standard of care for local treatment for extremities soft tissue sarcomas relies on conservative surgery combined with external beam radiotherapy. Brachytherapy can be realized instead of external beam radiotherapy in selected cases, or more often used as a boost dose on a limited volume on the area at major risk of relapse, especially if a microscopic positive resection is expected. Close interaction and communication between radiation oncologists and surgeons are mandatory at the time of implantation to limit the risk of side effects...
October 2016: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
Mehmet Sabri Balik, Adem Erkut, Yılmaz Guvercin, Recep Bedir
A calcification mass was incidentally found in the soft tissue of a patient who had a history of trauma to the extremity during examination. The patient had no symptom. The pathological analysis of the mass revealed it was an early-phase synovial sarcoma (SS). The diagnosis was made before the onset of symptoms and proper surgical intervention was performed. Therefore, in case of a <1 cm lesion clinically suspicious of myositis ossificans, SS should be taken into consideration as a possible diagnosis.
September 2016: Knee Surgery & related Research
Nicole A Larrier, Brian G Czito, David G Kirsch
Soft tissue sarcomas are rare mesenchymal cancers that pose a treatment challenge. Although small superficial soft tissue sarcomas can be managed by surgery alone, adjuvant radiotherapy in addition to limb-sparing surgery substantially increases local control of extremity sarcomas. Compared with postoperative radiotherapy, preoperative radiotherapy doubles the risk of a wound complication, but decreases the risk for late effects, which are generally irreversible. For retroperitoneal sarcomas, intraoperative radiotherapy can be used to safely escalate the radiation dose to the tumor bed...
October 2016: Surgical Oncology Clinics of North America
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