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https://www.readbyqxmd.com/read/28749474/racial-ethnic-differences-in-multiple-gene-sequencing-results-for-hereditary-cancer-risk
#1
Jennifer L Caswell-Jin, Tanya Gupta, Evan Hall, Iva M Petrovchich, Meredith A Mills, Kerry E Kingham, Rachel Koff, Nicolette M Chun, Peter Levonian, Alexandra P Lebensohn, James M Ford, Allison W Kurian
PurposeWe examined racial/ethnic differences in the usage and results of germ-line multiple-gene sequencing (MGS) panels to evaluate hereditary cancer risk.MethodsWe collected genetic testing results and clinical information from 1,483 patients who underwent MGS at Stanford University between 1 January 2013 and 31 December 2015.ResultsAsians and Hispanics presented for MGS at younger ages than whites (48 and 47 vs. 55; P = 5E-16 and 5E-14). Across all panels, the rate of pathogenic variants (15%) did not differ significantly between racial groups...
July 27, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/28749436/disparities-in-snacking-trends-in-us-adults-over-a-35-year-period-from-1977-to-2012
#2
Elizabeth K Dunford, Barry M Popkin
BACKGROUND: Previous studies have indicated that snacking is contributing to increased calories in the American diet, and that the contribution of snacks to energy intake has increased in recent decades. OBJECTIVE: The objective was to examine trends in the energy intake deriving from snacks and food sources of snacks for US adults over 35 years from 1977 to 2012, and whether these trends differ across sociodemographic groups. METHODS: Participants included 74,291 US adults aged ≥19 years who participated in the 1977-1978 Nationwide Food Consumption Survey (NFCS); the 1989-1991 Continuing Survey of Food Intake by Individuals (CSFII), the 1994-1996 CSFII, the 1997-1998 CSFII, National Health and Nutrition Examination Survey (NHANES) 2003-2004, NHANES 2005-2006, NHANES 2009-2010 and NHANES 2011-2012; all surveys are a stratified random sample of the total civilian, non-institutionalized US population...
July 27, 2017: Nutrients
https://www.readbyqxmd.com/read/28749033/co-occurring-down-syndrome-and-sucla2-related-mitochondrial-depletion-syndrome
#3
Natario L Couser, Daniel S Marchuk, Laurie D Smith, Alexandra Arreola, Kathleen A Kaiser-Rogers, Joseph Muenzer, Arti Pandya, Muge Gucsavas-Calikoglu, Cynthia M Powell
Mitochondrial DNA depletion syndrome 5 (MIM 612073) is a rare autosomal recessive disorder caused by homozygous or compound heterozygous pathogenic variants in the beta subunit of the succinate-CoA ligase gene located within the 13q14 band. We describe two siblings of Hispanic descent with SUCLA2-related mitochondrial depletion syndrome (encephalomyopathic form with methylmalonic aciduria); the older sibling is additionally affected with trisomy 21. SUCLA2 sequencing identified homozygous p.Arg284Cys pathogenic variants in both patients...
July 27, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28748403/evaluation-of-innotyper%C3%A2-21-in-a-sample-of-rio-de-janeiro-population-as-an-alternative-forensic-panel
#4
R S Moura-Neto, I C T Mello, R Silva, A P C Maette, C G Bottino, A Woerner, J King, F Wendt, B Budowle
The use of bi-allelic markers such as retrotransposable element insertion polymorphisms or Innuls (for insertion/null) can overcome some limitations of short tandem repeat (STR) loci in typing forensic biological evidence. This study investigated the efficiency of the InnoTyper® 21 Innul markers in an urban admixed population sample in Rio de Janeiro (n = 40) and one highly compromised sample collected as evidence by the Rio de Janeiro police. No significant departures from Hardy-Weinberg equilibrium were detected after the Bonferroni correction (α' ≈ 0...
July 26, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28748344/cigarette-smoking-attributable-burden-of-cancer-by-race-and-ethnicity-in-the-united-states
#5
Joannie Lortet-Tieulent, Ivana Kulhánová, Eric J Jacobs, Jan Willem Coebergh, Isabelle Soerjomataram, Ahmedin Jemal
PURPOSE: Cigarette smoking is the leading preventable cause of death and disability from cancer in the U.S. Smoking prevalence varies by racial and ethnic group, and therefore the smoking-related burden of cancer is expected to vary accordingly. METHODS: We estimated the cigarette smoking-attributable Disability-Adjusted Life Years (DALYs) lost to cancer, overall and within racial/ethnic groups, using published DALY estimates, smoking prevalence from survey data, and relative risks from large cohort studies...
July 26, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28748300/psychological-distress-of-ethnically-diverse-adult-caregivers-in-the-california-health-interview-survey
#6
Oanh L Meyer, Xiaoyan Liu, Thuc-Nhi Nguyen, Ladson Hinton, Daniel Tancredi
This study examined factors associated with psychological distress for culturally diverse family caregivers using a population-based sample. Data were analyzed from the 6634 caregivers of adults (i.e. elderly as well as non-elderly) who self-reported as non-Hispanic White, Mexican, Chinese, or Vietnamese in the 2009 California Health Interview Survey. Simple and multiple regression analyses were conducted to assess the potential influence of race/ethnicity, caregiving context, and social contextual variables on psychological distress...
July 26, 2017: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/28748293/racial-disparities-in-outcomes-of-operatively-treated-lower-extremity-fractures
#7
Adam Driesman, Nina Fisher, Sanjit R Konda, Christian A Pean, Philipp Leucht, Kenneth A Egol
PURPOSE: Whether racial differences are associated with function in the long term following surgical repair of lower extremity fractures has not been investigated. The purpose of this study is to compare how race affects function at 3, 6 and 12 months post-surgery following certain lower extremity fractures. METHODS: Four hundred and eighteen patients treated operatively for a lower extremity fracture (199 tibial plateau, 39 tibial shaft, and 180 rotational ankle fractures) were prospectively followed for 1 year...
July 26, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28748197/incidence-long-term-outcomes-and-healthcare-utilization-of-patients-with-human-immunodeficiency-virus-acquired-immune-deficiency-syndrome-and-disseminated-mycobacterium-avium-complex-from-1992-2015
#8
Lauren F Collins, Meredith E Clement, Jason E Stout
BACKGROUND: Despite the advent of combination antiretroviral therapy (cART), patients with human immunodeficiency virus (HIV) continue to develop late-stage complications including acquired immune deficiency syndrome (AIDS), disseminated Mycobacterium avium complex (DMAC), and death. METHODS: We performed an observational retrospective cohort study of HIV-infected adults who developed DMAC in the Duke University Health System from 1992 to 2015 to determine the incidence, long-term outcomes, and healthcare utilization of this population at high risk for poor outcomes...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28748192/extranodal-nk-t-cell-lymphoma-nasal-type-presenting-as-refractory-pseudomonas-aeruginosa-facial-cellulitis
#9
Erika Reategui Schwarz, Katerina G Oikonomou, Megan Reynolds, Juliette Kim, Rajeev L Balmiki, Stephanie A Sterling
Extranodal natural killer T-cell lymphoma, nasal type (ENKL), formerly called lethal midline granuloma or angiocentric T-cell lymphoma, is a predominantly extranodal non-Hodgkin lymphoma characterized by vascular damage, necrosis, and an association with Epstein-Barr virus. In the United States, it is more frequently seen in Asian, Asian Pacific Islander, and Hispanic descent populations and is more prevalent in males in their fifth decade. Clinical presentation of NK nasal lymphoma most commonly involves epistaxis; obstruction; discharge; destructive mass in sinuses, palate, and nose; and skin ulceration...
July 2017: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/28747571/age-specific-sex-difference-in-the-incidence-of-hepatocellular-carcinoma-in-the-united-states
#10
Pian Liu, Shao-Hua Xie, Shaobo Hu, Xiang Cheng, Tianyi Gao, Chen Zhang, Zifang Song
BACKGROUND: Hepatocellular carcinoma possesses a notable sex difference in incidence, and a protective role of estrogens has been hypothesized. METHODS: Using data from 13 cancer registries in the Surveillance, Epidemiology, and End Results Program, we describe the age-specific sex difference in the incidence of hepatocellular carcinoma in the United States during 1992-2013. We used a curve fitting by non-linear regression to quantitatively characterize the age-specific incidence rate of hepatocellular carcinoma by sex...
July 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28747492/responsiveness-to-cigarette-prices-by-different-racial-ethnic-groups-of-us-adults
#11
Tingting Yao, Michael K Ong, Wendy Max, Courtney Keeler, Yingning Wang, Valerie B Yerger, Hai-Yen Sung
OBJECTIVE: To evaluate the impact of cigarette prices on adult smoking for four US racial/ethnic groups: whites, African-Americans, Asians and Hispanics. METHODS: We analysed pooled cross-sectional data from the 2006/2007 and 2010/2011 Tobacco Use Supplement to the Current Population Survey (n=339 921 adults aged 18+) and cigarette price data from the Tax Burden on Tobacco. Using a two-part econometric model of cigarette demand that controlled for sociodemographic characteristics, state-level antismoking sentiment, local-level smoke-free air laws and monthly indicator, we estimated for each racial/ethnic group the price elasticities of smoking participation, smoking intensity and total demand for cigarettes...
July 26, 2017: Tobacco Control
https://www.readbyqxmd.com/read/28747255/adjuvant-gemcitabine-docetaxel-chemotherapy-for-stage-i-uterine-leiomyosarcoma-trends-and-survival-outcomes
#12
Ramey D Littell, Lue-Yen Tucker, Tina Raine-Bennett, Ted E Palen, Eve Zaritsky, Romain Neugebauer, Julia Embry-Schubert, Scott E Lentz
OBJECTIVE: To assess recent trends of administering adjuvant gemcitabine-docetaxel (GD) chemotherapy for Stage I uterine leiomyosarcoma, and to compare disease-free and overall survival between women who received and did not receive adjuvant GD chemotherapy. METHODS: All patients diagnosed with Stage I uterine leiomyosarcoma in a California-Colorado population-based health plan inclusive of 2006-2013 were included in a retrospective cohort. Adjuvant GD chemotherapy rates, clinico-pathologic characteristics and survival estimates were assessed...
July 24, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28744699/evaluating-iowa-severe-maternal-morbidity-trends-and-maternal-risk-factors-2009-2014
#13
Brittni N Frederiksen, Catherine J Lillehoj, Debra J Kane, Dave Goodman, Kristin Rankin
Objectives To describe statewide SMM trends in Iowa from 2009 to 2014 and identify maternal characteristics associated with SMM, overall and by age group. Methods We used 2009-2014 linked Iowa birth certificate and hospital discharge data to calculate SMM based on a 25-condition definition and 24-condition definition. The 24-condition definition parallels the 25-condition definition, but excludes blood transfusions. We calculated SMM rates for all delivery hospitalizations (N = 196,788) using ICD-9-CM diagnosis and procedure codes...
July 25, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/28742913/the-effect-of-nursing-quality-improvement-and-mobile-health-interventions-on-infant-sleep-practices-a-randomized-clinical-trial
#14
Rachel Y Moon, Fern R Hauck, Eve R Colson, Ann L Kellams, Nicole L Geller, Timothy Heeren, Stephen M Kerr, Emily E Drake, Kawai Tanabe, Mary McClain, Michael J Corwin
Importance: Inadequate adherence to recommendations known to reduce the risk of sudden unexpected infant death has contributed to a slowing in the decline of these deaths. Objective: To assess the effectiveness of 2 interventions separately and combined to promote infant safe sleep practices compared with control interventions. Design, Setting, and Participants: Four-group cluster randomized clinical trial of mothers of healthy term newborns who were recruited between March 2015 and May 2016 at 16 US hospitals with more than 100 births annually...
July 25, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28742704/racial-ethnic-disparities-in-longer-term-outcomes-among-emergency-general-surgery-patients-the-unique-experience-of-universally-insured-older-adults
#15
Cheryl K Zogg, Wei Jiang, Taylor D Ottesen, Shahid Shafi, Kevin Schuster, Robert Becher, Kimberly A Davis, Adil H Haider
OBJECTIVES: To determine whether racial/ethnic disparities in 30/90/180-day mortality, major morbidity, and unplanned readmissions exist among universally insured older adult (≥65 years) emergency general surgery patients; vary by diagnostic category; and can be explained by variations in geography, teaching status, age-cohort, and a hospital's percentage of minority patients. SUMMARY OF BACKGROUND DATA: As the US population ages and discussions surrounding the optimal method of insurance provision increasingly enter into national debate, longer-term outcomes are of paramount concern...
July 24, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28739461/perforator-vein-access-for-venous-pharmacomechanical-thrombolysis
#16
Afsha Aurshina, Arkady Ganelin, Anil Hingorani, Borislav Kheyson, Natalie Marks, Enrico Ascher
A 28-year-old Hispanic female with a history of deep vein thrombosis presented to the emergency room with left lower extremity swelling and pain. On duplex venous exam, an extensive left lower extremity DVT extending to her left common iliac vein was identified. A perforator vein measuring 2.6 mm located in the mid-calf area was used to access and perform mechanical and chemical thrombolysis. Complete resolution of symptoms was observed.
July 21, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28739148/food-insecurity-and-adult-overweight-obesity-gender-and-race-ethnic-disparities
#17
Daphne C Hernandez, Layton M Reesor, Rosenda Murillo
The majority of the food insecurity-obesity research has indicated a positive association among women, especially minority women. Less research has been conducted on men, and the findings are inconsistent. The aim was to assess whether gender and race/ethnic disparities exists between the food insecurity and overweight/obesity relationship among adults ages 18-59. We used the cross-sectional 2011 and 2012 National Health Interview Survey data (N = 19,990). Three or more affirmative responses on the 10-item USDA Food Security Scale indicated food insecure experiences...
July 21, 2017: Appetite
https://www.readbyqxmd.com/read/28739122/idiopathic-granulomatous-mastitis-a-diagnostic-and-therapeutic-challenge
#18
C M Freeman, B T Xia, G C Wilson, J D Lewis, S Khan, S J Lee, E E Lower, M J Edwards, E A Shaughnessy
BACKGROUND: Idiopathic granulomatous mastitis is a rare benign breast disease of women of reproductive age. It usually presents as a painful mass. Since the etiology is unclear, directed diagnosis and management is lacking. METHODS: This is a retrospective chart review of 14 patients, over twelve years (2004-2016), identified through query of pathology findings. RESULTS: Two asymptomatic patients were diagnosed after oncologic breast resection following neoadjuvant chemotherapy...
July 8, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28738127/early-onset-alzheimer-disease-and-candidate-risk-genes-involved-in-endolysosomal-transport
#19
Brian W Kunkle, Badri N Vardarajan, Adam C Naj, Patrice L Whitehead, Sophie Rolati, Susan Slifer, Regina M Carney, Michael L Cuccaro, Jeffery M Vance, John R Gilbert, Li-San Wang, Lindsay A Farrer, Christiane Reitz, Jonathan L Haines, Gary W Beecham, Eden R Martin, Gerard D Schellenberg, Richard P Mayeux, Margaret A Pericak-Vance
Importance: Mutations in APP, PSEN1, and PSEN2 lead to early-onset Alzheimer disease (EOAD) but account for only approximately 11% of EOAD overall, leaving most of the genetic risk for the most severe form of Alzheimer disease unexplained. This extreme phenotype likely harbors highly penetrant risk variants, making it primed for discovery of novel risk genes and pathways for AD. Objective: To search for rare variants contributing to the risk for EOAD. Design, Setting, and Participants: In this case-control study, whole-exome sequencing (WES) was performed in 51 non-Hispanic white (NHW) patients with EOAD (age at onset <65 years) and 19 Caribbean Hispanic families previously screened as negative for established APP, PSEN1, and PSEN2 causal variants...
July 24, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28737667/prenatal-vitamin-d-intake-cord-blood-25-hydroxyvitamin-d-and-offspring-body-composition-the-healthy-start-study
#20
Katherine A Sauder, Hallie J Koeppen, Allison L B Shapiro, Kathryn E Kalata, Alexandra V Stamatoiu, Brandy M Ringham, Deborah H Glueck, Jill M Norris, Dana Dabelea
Vitamin D deficiency in pregnancy may be associated with increased offspring adiposity, but evidence from human studies is inconclusive. We examined associations between prenatal vitamin D intake, 25-hydroxyvitamin D (25(OH)D) in cord blood, and offspring size and body composition at birth and 5 months. Participants included 605 mother-offspring dyads from the Healthy Start study, an ongoing, pre-birth prospective cohort study in Denver, Colorado, USA. Prenatal vitamin D intake was assessed with diet recalls and questionnaires, and offspring body composition was measured via air displacement plethysmography at birth and 5 months...
July 22, 2017: Nutrients
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