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https://www.readbyqxmd.com/read/28815175/platelet-rich-plasma-an-elixir-for-treatment-of-alopecia-personal-experience-on-117-patients-with-review-of-literature
#1
REVIEW
Suruchi Garg, Shweta Manchanda
Platelet-rich plasma (PRP) has emerged as a new treatment modality in regenerative plastic surgery and dermatology. PRP is a simple, cost-effective and feasible treatment option with high patient satisfaction for hair loss and can be regarded as a valuable adjuvant treatment modality for androgenic alopecia and other types of non-scarring alopecias. Authors have proposed a hair model termed "Golden anchorage with 'molecular locking' of ectodermal and mesenchymal components for survival and integrity of hair follicle (HF)" in this article...
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/28771982/original-article-platelet-rich-plasma-with-microneedling-in-androgenetic-alopecia-along-with-dermoscopic-pre-and-post-treatment-evaluation
#2
Abhijeet Kumar Jha, Uday Kumar Udayan, Prasoon Kumar Roy, Amar Kant Jha Amar, R K P Chaudhary
BACKGROUND: Platelet-rich plasma has shown beneficial effects in the treatment of androgenic alopecia with its growth factor properties in accelerating the dermal papilla. Dermoscopy is a noninvasive method that allows the in vivo evaluation of microstructures not visible to the naked eye. OBJECTIVE: To ascertain the role of platelet-rich plasma (PRP) with microneedling, and to compare the pre- and post-treatment dermoscopic features in androgenetic alopecia. (AGA)...
August 3, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28757064/synthesis-and-anti-tumor-evaluation-of-panaxadiol-halogen-derivatives
#3
Shengnan Xiao, Shuai Chen, Yuanyuan Sun, Wuxi Zhou, Huri Piao, Yuqing Zhao
In the current work, 13 novel panaxadiol (PD) derivatives were synthesized by reacting with chloroacetyl chloride and bromoacetyl bromide. Their in vitro antitumor activities were evaluated on three human tumor cell lines (HCT-116, BGC-823, SW-480) and three normal cells (human gastric epithelial cell line-GES-1, hair follicle dermal papilla cell line-HHDPC and rat myocardial cell line-H9C2) by MTT assay. Compared with PD, the results demonstrated that compound 1e, 2d, 2e showed significant anti-tumor activity against three tumor cell lines, the IC50 value of compound 2d against HCT-116 was the lowest (3...
June 24, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28735299/identification-of-the-first-dominant-mutation-of-lama5-gene-causing-a-complex-multisystem-syndrome-due-to-dysfunction-of-the-extracellular-matrix
#4
Simone Sampaolo, Filomena Napolitano, Alfonsina Tirozzi, Mafalda Giovanna Reccia, Luca Lombardi, Olimpia Farina, Adriano Barra, Ferdinando Cirillo, Mariarosa Anna Beatrice Melone, Fernando Gianfrancesco, Giuseppe Di Iorio, Teresa Esposito
BACKGROUND: The laminin alpha 5 gene (LAMA5) plays a master role in the maintenance and function of the extracellular matrix (ECM) in mammalian tissues, which is critical in developmental patterning, stem cell niches, cancer and genetic diseases. Its mutations have never been reported in human disease so far. The aim of this study was to associate the first mutation in LAMA5 gene to a novel multisystem syndrome. METHODS: A detailed characterisation of a three-generation family, including clinical, biochemical, instrumental and morphological analysis, together with genetics and expression (WES and RNAseq) studies, was performed...
July 22, 2017: Journal of Medical Genetics
https://www.readbyqxmd.com/read/28725654/stem-cells-from-human-hair-follicles-first-mechanical-isolation-for-immediate-autologous-clinical-use-in-androgenetic-alopecia-and-hair-loss
#5
Pietro Gentile, Maria G Scioli, Alessandra Bielli, Augusto Orlandi, Valerio Cervelli
BACKGROUND: Hair follicles are known to contain a well-characterized niche for adult stem cells: the bulge, which contains epithelial and melanocytic stem cells. Stem cells in the hair bulge, a clearly demarcated structure within the lower permanent portion of hair follicles, can generate the interfollicular epidermis, hair follicle structures, and sebaceous glands. The bulge epithelial stem cells can also reconstitute in an artificial in vivo system to a new hair follicle. METHODS: In this study, we have developed a new method to isolate human adult stem cells by mechanical centrifugation of punch biopsy from human hair follicles without culture condition...
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/28711498/promotion-of-hair-growth-by-newly-synthesized-ceramide-mimetic-compound
#6
Bu-Mahn Park, Soon-Sun Bak, Kyung-Oh Shin, Minhee Kim, Daehwan Kim, Sang-Hun Jung, Sekyoo Jeong, Young Kwan Sung, Hyun Jung Kim
Based on the crucial roles of ceramides in skin barrier function, use of ceramides or their structural mimetic compounds, pseudoceramides, as cosmetic ingredients are getting more popular. While currently used pseudoceramides are intended to substitute the structural roles of ceramides in stratum corneum, development of bioactive pseudoceramides has been repeatedly reported. In this study, based on the potential involvement of sphingolipids in hair cycle regulation, we investigated the effects of newly synthesized pseudoceramide, bis-oleamido isopropyl alcohol (BOI), on hair growth using cultured human hair follicles and animal models...
July 13, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28708295/cd13-is-a-marker-for-onychofibroblasts-within-nail-matrix-onychodermis-comparison-of-its-expression-patterns-in-the-nail-unit-and-in-the-hair-follicle
#7
Ji-Hye Park, Dong-Youn Lee, Kee-Taek Jang, Sang-Yun Ha, Ghee Young Kwon, Kyung-Hoon Lee, Jong Sup Shim, Eun Ji Kwon
BACKGROUND: We previously demonstrated the presence of onychodermis, a specialized mesenchymal cell population beneath the the nail matrix and proximal nail bed demonstrating CD10 expression. We hypothesize that the onychodermis could be the nail analog of the follicular dermal papilla, which is known to express CD13. We compare CD13 expression patterns between specialized mesenchymes of nail and hair, and compare these findings with CD10 expression patterns. METHODS: CD10 and CD13 immunohistochemisty was performed on polydactyly and adult cadaveric nail units, and on hair follicles in scalp nevus sebaceus excision specimens...
July 14, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28670518/hair-follicle-generation-by-injections-of-adult-human-follicular-epithelial-and-dermal-papilla-cells-into-nude-mice
#8
Mohammadali Nilforoushzadeh, Elham Rahimi Jameh, Fariba Jaffary, Ehsan Abolhasani, Gelavizh Keshtmand, Hajar Zarkob, Parvaneh Mohammadi, Nasser Aghdami
OBJECTIVE: Dermal papilla and hair epithelial stem cells regulate hair formation and the growth cycle. Damage to or loss of these cells can cause hair loss. Although several studies claim to reconstitute hairs using rodent cells in an animal model, additional research is needed to develop a stable human hair follicle reconstitution protocol. In this study, we have evaluated hair induction by injecting adult cultured human dermal papilla cells and a mixture of hair epithelial and dermal papilla cells in a mouse model...
July 2017: Cell Journal
https://www.readbyqxmd.com/read/28668474/dermal-blimp1-acts-downstream-of-epidermal-tgf%C3%AE-and-wnt-%C3%AE-catenin-to-regulate-hair-follicle-formation-and-growth
#9
Stephanie B Telerman, Emanuel Rognoni, Inês Sequeira, Angela Oliveira Pisco, Beate M Lichtenberger, Oliver Culley, Priyalakshmi Viswanathan, Ryan R Driskell, Fiona M Watt
Blimp1 is a transcriptional repressor that regulates cell growth and differentiation in multiple tissues, including skin. While in the epidermis Blimp1 is important for keratinocyte and sebocyte differentiation, its role in dermal fibroblast is unclear. Here we show that Blimp1 is dynamically regulated in dermal papilla (DP) cells during hair follicle (HF) morphogenesis and the postnatal hair cycle, preceding dermal Wnt/β-catenin activation. Blimp1 ablation in E12.5 mouse dermal fibroblasts delayed HF morphogenesis and growth and prevented new HF formation following wounding...
June 28, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28662062/reflectance-confocal-microscopy-features-of-braf-v600e-mutated-thin-melanomas-detected-by-immunohistochemistry
#10
Ana Claudia Urvanegia, Juliana Casagrande Tavoloni Braga, Danielle Shitara, Jose Humberto Fregnani, Jose Ivanildo Neves, Clovis Antonio Pinto, Ashfaq A Marghoob, Joao Pedreira Duprat, Gisele Gargantini Rezze
The classification of melanoma into four histological subtypes has been questioned regarding its clinical validity in providing relevant information for treatment for metastatic tumors. Specific genetic alterations are associated with particular clinical and histopathological features, suggesting that these could be helpful in refining existing melanoma classification schemes. We analyzed BRAF V600E mutated melanomas to explore the Reflectance confocal microscopy (RCM) utility as a screening aid in the evaluation of the most appropriate patients for genetic testing...
2017: PloS One
https://www.readbyqxmd.com/read/28627680/bmp%C3%A2-7-suppresses-excessive-scar-formation-by-activating-the-bmp%C3%A2-7-smad1-5-8-signaling-pathway
#11
Jingdong Guo, Quan Lin, Ying Shao, Li Rong, Duo Zhang
Scarring is the inevitable consequence of wound repair, which may cause significant physical and mental pain to patients when excessive. Bone morphogenetic protein‑7 (BMP‑7) has been proved to inhibit TGF‑β‑induced fibrosis in various tissues including dermal papilla cells. However, the effect of BMP‑7 on hypertrophic scarring, a common proliferative disorder of dermal fibroblasts, has not been determined. To overcome this problem, the present study established a mouse model of thermal injury to investigate the inhibitory effects of BMP‑7 on scar formation...
August 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28609882/bythaelurus-vivaldii-a-new-deep-water-catshark-carcharhiniformes-scyliorhinidae-from-the-northwestern-indian-ocean-off-somalia
#12
Simon Weigmann, Carina Julia Kaschner
A new very small deep-water catshark, Bythaelurus vivaldii, is described based on two female specimens caught off Somalia in the northwestern Indian Ocean during the German 'Valdivia' expedition in 1899. It is morphologically closest to the recently described B. bachi, which is the only other Bythaelurus species in the western Indian Ocean that shares a stout body of large specimens and the presence of oral papillae. It further resembles B. vivaldii in the broad mouth and broad posterior head, but differs in the presence of composite oral papillae and a higher diversity in dermal denticle morphology...
May 8, 2017: Zootaxa
https://www.readbyqxmd.com/read/28595998/targeting-of-cxxc5-by-a-competing-peptide-stimulates-hair-re-growth-and-wound-induced-hair-neogenesis
#13
Soung-Hoon Lee, Seol Hwa Seo, Dong-Hwan Lee, Long-Quan Pi, Won-Soo Lee, Kang-Yell Choi
The Wnt/β-catenin pathway has been implicated in hair follicle development and hair regeneration in adults. We discovered that CXXC-type zinc finger protein 5 (CXXC5) is a negative regulator of the Wnt/β-catenin pathway involved in hair re-growth and wound-induced hair follicle neogenesis (WIHN) via an interaction with Dishevelled (Dvl). CXXC5 was up-regulated in miniaturized hair follicles and arrector pili muscles in human balding scalps. The inhibitory effects of CXXC5 on alkaline phosphatase activity and cell proliferation were demonstrated using human hair follicle dermal papilla cells...
June 5, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28584630/connexin-43-key-roles-in-the-skin
#14
Xiao-Fei Zhang, Xiaofeng Cui
Gap junctions are tightly packed intercellular channels that serve a common purpose of allowing the intercellular exchange of small metabolites, second messengers and electrical signals. Connexins (Cxs) are gap junction proteins. Currently, 20 and 21 members of Cxs have been characterized in mice and humans, respectively. Connexin 43 (Cx43) is the most ubiquitously expressed type of Cx in the skin. It is produced by various different types of skin cell, such as keratinocytes, fibroblasts, endothelial and basal cells, melanocytes and dermal papilla cells...
June 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28541264/basement-membrane-matrix-promotes-the-efficiency-of-hair-follicle-reconstruction-in-vivo-and-is-a-cell-delivery-vehicle-for-follicle-regeneration
#15
Shune Xiao, Yong Miao, Jin Wang, Bojie Lin, Zhiqi Hu
BACKGROUND: The efficiency of hair follicle (HF) reconstruction is decreased by extensive apoptotic remodeling that occurs soon after grafting. OBJECTIVE: To evaluate a basement membrane matrix (matrix) to improve the efficiency of HF reconstruction and serve as a cell delivery vehicle. MATERIALS AND METHODS: Newborn mouse skin cells were suspended in a matrix and transplanted in a chamber assay. The viability and proliferation of mouse dermal papilla cells seeded in the matrix were tested...
June 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28539964/preclinical-and-clinical-studies-demonstrate-that-the-proprietary-herbal-extract-da-5512-effectively-stimulates-hair-growth-and-promotes-hair-health
#16
Jae Young Yu, Biki Gupta, Hyoung Geun Park, Miwon Son, Joon-Ho Jun, Chul Soon Yong, Jeong Ah Kim, Jong Oh Kim
The proprietary DA-5512 formulation comprises six herbal extracts from traditional oriental plants historically associated with therapeutic and other applications related to hair. Here, we investigated the effects of DA-5512 on the proliferation of human dermal papilla cells (hDPCs) in vitro and on hair growth in C57BL/6 mice and conducted a clinical study to evaluate the efficacy and safety of DA-5512. DA-5512 significantly enhanced the viability of hDPCs in a dose-dependent manner (p < 0.05), and 100 ppm of DA-5512 and 1 μM minoxidil (MXD) significantly increased the number of Ki-67-positive cells, compared with the control group (p < 0...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28512199/dominant-negative-sox18-function-inhibits-dermal-papilla-maturation-and-differentiation-in-all-murine-hair-types
#17
Rehan Villani, Samantha Hodgson, Julien Legrand, Jessica Greaney, Ho Yi Wong, Cathy Pichol-Thievend, Christelle Adolphe, Brandon Wainwight, Mathias Francois, Kiarash Khosrotehrani
SOX family proteins SOX2 and SOX18 have been reported as being essential in determining hair follicle type; however, the role they play during development remains unclear. Here, we demonstrate that Sox18 regulates the normal differentiation of the dermal papilla of all hair types. In guard (primary) hair dermal condensate (DC) cells, we identified transient Sox18 in addition to SOX2 expression at E14.5, which allowed fate tracing of primary DC cells until birth. Similarly, expression of Sox18 was detected in the DC cells of secondary hairs at E16...
May 15, 2017: Development
https://www.readbyqxmd.com/read/28504397/hair-follicle-dermal-papilla-and-sheath-fibroblasts-provide-a-supportive-microenvironment-for-human-skin-regeneration
#18
P Kaur
No abstract text is available yet for this article.
May 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28497393/effect-of-miscanthus-sinensis-var-purpurascens-flower-extract-on-proliferation-and-molecular-regulation-in-human-dermal-papilla-cells-and-stressed-c57bl-6-mice
#19
GiHee Jeong, William A Boisvert, Mei-Zhu Xi, Yi-Lin Zhang, Young-Bin Choi, Sunghun Cho, Sanghyun Lee, Changsun Choi, Bog-Hieu Lee
OBJECTIVES: To investigate the hair growth-promoting effect of Miscanthus sinensis var. purpurascens (MSP) flower extracton on in vitro and in vivo models. METHODS: MSP flower extract was extracted in 99.9% methanol and applied to examine the proliferation of human dermal papilla cells (hDPCs) in vitro at the dose of 3.92-62.50 μg/mL and hair growth of C57BL/6 mice in vivo at the dose of 1000 μg/mL. The expression of transforming growth factor β1 (TGF-β1), hepatocyte growth factor (HGF), β-catenin, substance P was measured by relative quantitative realtime polymerase chain reaction...
May 11, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28475144/undariopsis-peterseniana-promotes-hair-growth-by-the-activation-of-wnt-%C3%AE-catenin-and-erk-pathways
#20
Jung-Il Kang, Min-Kyoung Kim, Ji-Hyeok Lee, You-Jin Jeon, Eun-Kyoung Hwang, Young-Sang Koh, Jin-Won Hyun, Soon-Young Kwon, Eun-Sook Yoo, Hee-Kyoung Kang
In this study, we investigated the effect and mechanism of Undariopsis peterseniana, an edible brown alga, on hair growth. The treatment of vibrissa follicles with U. peterseniana extract ex vivo for 21 days significantly increased the hair-fiber lengths. The U. peterseniana extract also significantly accelerated anagen initiation in vivo. Moreover, we found that U. peterseniana extract was able to open the KATP channel, which may contribute to increased hair growth. The U. peterseniana extract decreased 5α-reductase activity and markedly increased the proliferation of dermal papilla cells, a central regulator of the hair cycle...
May 5, 2017: Marine Drugs
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