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Dermal papilla

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https://www.readbyqxmd.com/read/29140150/radiotherapy-for-cervical-cancer-impact-on-the-vaginal-epithelium-and-sexual-function
#1
Alexandra Hofsjö, Karin Bergmark, Bo Blomgren, Helen Jahren, Nina Bohm-Starke
BACKGROUND: Women who have been treated for cervical cancer have persistent changes in their sexual function, which result in considerable distress. The aim of this study was to investigate the morphology of the vaginal epithelium in cervical cancer survivors treated with radiotherapy and its correlation to serum levels of sex steroid hormones and sexual function. MATERIAL AND METHODS: We included 34 patients treated for cervical cancer with radiotherapy and 37 healthy age-matched control women scheduled for benign gynecological surgery...
November 15, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/29138430/extracellular-vesicles-derived-from-mscs-activates-dermal-papilla-cell-in-vitro-and-promotes-hair-follicle-conversion-from-telogen-to-anagen-in-mice
#2
Ramya Lakshmi Rajendran, Prakash Gangadaran, Soon Sun Bak, Ji Min Oh, Senthilkumar Kalimuthu, Ho Won Lee, Se Hwan Baek, Liya Zhu, Young Kwan Sung, Shin Young Jeong, Sang-Woo Lee, Jaetae Lee, Byeong-Cheol Ahn
Hair loss is a common medical problem. In this study, we investigated the proliferation, migration, and growth factor expression of human dermal papilla (DP) cells in the presence or absence of treatment with mesenchymal stem cell extracellular vesicles (MSC-EVs). In addition, we tested the efficacy of MSC-EV treatment on hair growth in an animal model. MSC-EV treatment increased DP cell proliferation and migration, and elevated the levels of Bcl-2, phosphorylated Akt and ERK. In addition; DP cells treated with MSC-EVs displayed increased expression and secretion of VEGF and IGF-1...
November 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29129979/hair-germ-model-in-vitro-via-human-postnatal-keratinocyte-dermal-papilla-interactions-impact-of-hyaluronic-acid
#3
Ekaterina Kalabusheva, Vasily Terskikh, Ekaterina Vorotelyak
Hair follicle (HF) reconstruction in vitro is a promising field in alopecia treatment and human HF development research. Here, we combined postnatal human dermal papilla (DP) cells and skin epidermal keratinocytes (KCs) in a hanging drop culture to develop an artificial HF germ. The method is based on DP cell hair-inducing properties and KC self-organization. We evaluated two protocols of aggregate assembling. Mixed HF germ-like structures demonstrated the initiation of epithelial-mesenchymal interaction, including WNT pathway activation and expression of follicular markers...
2017: Stem Cells International
https://www.readbyqxmd.com/read/29119273/immunohistochemical-distribution-of-ki67-in-epidermis-of-thick-glabrous-skin-of-human-digits
#4
Aleksandar Petrovic, Vladimir Petrovic, Bobana Milojkovic, Ivan Nikolic, Dragan Jovanovic, Aleksandra Antovic, Miroslav Milic
The glabrous skin on the flexor sides of hands and feet, compared to other integument regions, has thicker epidermis and more complex pattern of epidermal ridges, wherefore in microscopy is denominated as thick skin. The epidermis of this skin type has individually unique and permanent superficial patterns, called dermatoglyphics, which are maintained by regenerative potential of deep epidermal rete ridges, that interdigitate with adjacent dermis. Using light microscopy, we analyzed cadaveric big toes thick skin samples, described histology of deep epidermal ridges (intermediate, limiting, and transverse), and quantitatively evidenced their pattern of proliferation by immunohistochemical assessment of Ki67...
November 8, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29076290/the-effect-of-plasma-rich-in-growth-factors-combined-with-follicular-unit-extraction-surgery-for-the-treatment-of-hair-loss-a-pilot-study
#5
Roge M Navarro, Ander Pino, Asunción Martinez-Andres, Consuelo Molina, Ana María Martinez, Nahikari Martinez, Gorka Orive, Eduardo Anitua
BACKGROUND: Hair transplant surgery using follicular unit extraction technique (FUE) is a common surgical procedure for the treatment of severe hair loss. Blood-derived autologous growth factors have also proved to promote hair regeneration in patients with different types of alopecia. AIMS: The aim of this study was to evaluate the safety and clinical efficacy of plasma rich in growth factors (PRGF) technology as an adjuvant therapy for FUE surgery in hair loss affected patients...
October 26, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29060675/effect-of-laser-diode-light-irradiation-on-growth-capability-of-human-hair-follicle-dermal-papilla-cells
#6
S Jampa-Ngern, K Viravaidya-Pasuwat, S Suvanasuthi, A Khantachawana
Low level laser therapy is widely used to relieve pain and inflammation, and to restore cellular functions. The photons of light are absorbed by mitochondria in cells, leading to an increase in the production of adenosine triphosphate (ATP), nitric oxide release, blood flow, and reactive oxygen species (ROS). This study proposed the use of a laser diode array at 808 nm to stimulate the proliferation and to activate the functions of dermal papilla cells, which were an important part of the hair growth cycle...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29055410/getting-to-the-core-of-the-dermal%C3%A2-papilla
#7
Mingxing Lei, Li Yang, Cheng-Ming Chuong
Through coordinated and reciprocal interactions between the epithelium and mesenchyme, diverse integumentary organs form and undergo cyclic renewal. The hair follicle has become the main model to understand this extraordinary regenerative behavior. At the core is the dermal papilla, the organizing center, and the epithelial stem cells that respond to dermal papilla signaling. Two recent papers by Telerman et al. and Yang et al. unravel new molecular landscapes within the dermal papilla.
November 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29054756/a-lncrna-h19-transcript-from-secondary-hair-follicle-of-liaoning-cashmere-goat-identification-regulatory-network-and-expression-regulated-potentially-by-its-promoter-methylation
#8
Yu B Zhu, Ze Y Wang, Rong H Yin, Qian Jiao, Su J Zhao, Yu Y Cong, Hui L Xue, Dan Guo, Shi Q Wang, Yan X Zhu, Wen L Bai
The H19 transcript (imprinted maternally expressed transcript) is well-known as long noncoding RNA (lncRNA), and it is thought to be associated with the inductive capacity of dermal papilla cells for hair-follicle reconstruction. In this study, we isolated and characterized a lncRNA-H19 transcript from the secondary hair follicle of Liaoning cashmere goat. Also, we investigated its transcriptional pattern and methylation status of H19 gene in secondary hair follicle of this breed during different stages of hair follicle cycle...
October 17, 2017: Gene
https://www.readbyqxmd.com/read/29047245/11%C3%AE-hydroxysteroid-dehydrogenase-type-1-inhibition-attenuates-the-adverse-effects-of-glucocorticoids-on-dermal-papilla-cells
#9
Sang Eun Lee, Eun Young Lee, Sang Jin Kang, Seung Hun Lee
PURPOSE: Glucocorticoids, stress-related hormones, inhibit hair growth. Intracellular glucocorticoid availability is regulated by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). 11β-HSD1 was recently detected in keratinocytes and fibroblasts. However, the expression of 11β-HSD1 in human hair follicles remains unknown. We aimed to examine 11β-HSD1 expression in human dermal papilla cells (DPCs) and to investigate whether modulation of 11β-HSD1 activity can regulate the negative effects of glucocorticoids on DPCs...
November 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29032741/titrated-extract-of-centella-asiatica-increases-hair-inductive-property-through-inhibition-of-stat-signaling-pathway-in-three-dimensional-spheroid-cultured-human-dermal-papilla-cells
#10
Yeong Min Choi, Sungkwan An, Junwoo Lee, Jae Ho Lee, Jae Nam Lee, Young Sam Kim, Kyu Joong Ahn, In-Sook An, Seunghee Bae
Dermal papilla (DP) is a pivotal part of hair follicle, and the smaller size of the DP is related with the hair loss. In this study, we investigated the effect of titrated extract of Centella asiatica (TECA) on hair growth inductive property on 3D spheroid cultured human DP cells (HDP cells). Significantly increased effect of TECA on cell viability was only shown in 3D sphered HPD cells, not in 2D cultured HDP cells. Also, TECA treatment increased the sphere size of HDP cells. The luciferase activity of STAT reporter genes and the expression of STAT-targeted genes, SOCS1 and SOCS3, were significantly decreased...
October 16, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28994714/inhibition-of-5%C3%AE-reductase-il-6-secretion-and-oxidation-process-of-equisetum-debile-roxb-ex-vaucher-extract-as-functional-food-and-nutraceuticals-ingredients
#11
Wantida Chaiyana, Chanun Punyoyai, Suvimol Somwongin, Pimporn Leelapornpisid, Kornkanok Ingkaninan, Neti Waranuch, Jukkarin Srivilai, Natthawut Thitipramote, Wudtichai Wisuitiprot, Roswitha Schuster, Helmut Viernstein, Monika Mueller
This study aims to investigate the biological activities related to hair loss of Equisetum debile extracts, including 5α-reductase inhibition, interleukin-6 (IL-6) secretion reduction, and anti-oxidation. E. debile extracts were obtained by maceration in various solvents. Crude extract (CE) was obtained by maceration in 95% ethanol. Chlorophyll-free extract (CF) was the CE which of the chlorophyll has been removed by electrocoagulation. Hexane extract (HE), ethyl acetate extract (EA), and ethanolic extract (ET) were fraction extracts obtained from maceration in hexane, ethyl acetate, and 95% ethanol, respectively...
October 10, 2017: Nutrients
https://www.readbyqxmd.com/read/28979149/conventional-and-novel-stem-cell-based-therapies-for-androgenic-alopecia
#12
REVIEW
Dodanim Talavera-Adame, Daniella Newman, Nathan Newman
The prevalence of androgenic alopecia (AGA) increases with age and it affects both men and women. Patients diagnosed with AGA may experience decreased quality of life, depression, and feel self-conscious. There are a variety of therapeutic options ranging from prescription drugs to non-prescription medications. Currently, AGA involves an annual global market revenue of US$4 billion and a growth rate of 1.8%, indicating a growing consumer market. Although natural and synthetic ingredients can promote hair growth and, therefore, be useful to treat AGA, some of them have important adverse effects and unknown mechanisms of action that limit their use and benefits...
2017: Stem Cells and Cloning: Advances and Applications
https://www.readbyqxmd.com/read/28944964/wnt-%C3%AE-catenin-and-erk-pathway-activation-a-possible-mechanism-of-photobiomodulation-therapy-with-light-emitting-diodes-that-regulate-the-proliferation-of-human-outer-root-sheath-cells
#13
Jung E Kim, Young J Woo, Ki M Sohn, Kwan H Jeong, Hoon Kang
BACKGROUND: Outer root sheath cells (ORSCs) play important roles in maintaining hair follicle structure and provide support for the bulge area. The hair growth promoting effects of photobiomodulation therapy (PBMT) have been reported, but the mechanisms for this in human ORCs (hORSCs) have rarely been studied. OBJECTIVE: The aim of this study was to investigate the effect of various wavelengths of light-emitting diode (LED) irradiation on human ORSCs (hORSCs). METHODS: LED irradiation effects on hORSC proliferation and migration were examined with MTT assay, BrdU incorporation assay and migration assays...
September 25, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28916740/mad2b-acts-as-a-negative-regulatory-partner-of-tcf4-on-proliferation-in-human-dermal-papilla-cells
#14
Nanlan Yu, Zhiqiang Song, Kezhou Zhang, Xichuan Yang
Dermal papilla cells (DPCs) are important components of hair follicles and play a critical role in hair follicle development. However, the mechanisms by which DPCs induce hair follicle development remain unclear. In the present study, we identified the mitotic arrest deficient protein MAD2B as a modifier of DPCs. Overexpression of MAD2B inhibited DPC aggregative growth and proliferation induced by the Wnt signaling activator T cell factor 4 (TCF4), and decreased TCF4-induced expression and the release of hair growth-related cytokines, including hepatocyte growth factor, insulin-like growth factor-1, and vascular endothelial growth factor in DPCs...
September 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28912571/comparative-global-immune-related-gene-profiling-of-somatic-cells-human-pluripotent-stem-cells-and-their-derivatives-implication-for-human-lymphocyte-proliferation
#15
Chia-Eng Wu, Chen-Wei Yu, Kai-Wei Chang, Wen-Hsi Chou, Chen-Yu Lu, Elisa Ghelfi, Fang-Chun Wu, Pey-Shynan Jan, Mei-Chi Huang, Patrick Allard, Shau-Ping Lin, Hong-Nerng Ho, Hsin-Fu Chen
Human pluripotent stem cells (hPSCs), including embryonic stem cells (ESCs) and induced PSCs (iPSCs), represent potentially unlimited cell sources for clinical applications. Previous studies have suggested that hPSCs may benefit from immune privilege and limited immunogenicity, as reflected by the reduced expression of major histocompatibility complex class-related molecules. Here we investigated the global immune-related gene expression profiles of human ESCs, hiPSCs and somatic cells and identified candidate immune-related genes that may alter their immunogenicity...
September 15, 2017: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/28912032/androgens-and-androgen-receptor-action-in-skin-and-hair-follicles
#16
REVIEW
Julieta María Ceruti, Gustavo José Leirós, María Eugenia Balañá
Beyond sexual functions, androgens exert their action in skin physiology and pathophysiology. Skin cells are able to synthesize most active androgens from gonadal or adrenal precursors and the enzymes involved in skin steroidogenesis are implicated both in normal or pathological processes. Even when the role of androgens and androgen receptor (AR) in skin pathologies has been studied for decades, their molecular mechanisms in skin disorders remain largely unknown. Here, we analyze recent studies of androgens and AR roles in several skin-related disorders, focusing in the current understanding of their molecular mechanisms in androgenetic alopecia (AGA)...
September 12, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28906049/alitretinoin-treatment-of-lichen-amyloidosis
#17
Won Seon Koh, Eui Hyun Oh, Jeong Eun Kim, Young Suck Ro
Lichen amyloidosis (LA) is characterized by the deposition of amyloid that may respond to chronic scratching that may be secondary to atopic dermatitis, stasis dermatitis, or interface dermatitis. Despite the development of several therapeutic strategies, including topical steroids, oral antihistamines, cyclosporine, and retinoids, an effective treatment for LA has not been established. A 49-year-old woman who has been treated irregularly for atopic dermatitis for 7 years presented with localized brownish papules on the left forearm and right elbow...
September 14, 2017: Dermatologic Therapy
https://www.readbyqxmd.com/read/28875863/the-basic-mechanism-of-hair-growth-stimulation-by-adipose-derived-stem-cells-and-their-secretory-factors
#18
Chong-Hyun Won, Gyeong-Hun Park, Xunwei Wu, Thanh-Nga Tran, Ki-Young Park, Byung-Soon Park, Dong Young Kim, Ohsang Kwon, Kyu-Han Kim
Adipose-derived stem cells (ADSCs) are mesenchymal stem cells (MSCs) within the stromal vascular fraction of subcutaneous adipose tissue. ADSCs secrete growth factors and other proteins, and have been used to regenerate skin with satisfactory results. ADSCs promote hair growth in vitro, ex vivo, and in vivo. The conditioned media of ADSCs (ADSC-CM) increases the proliferation rate of human follicular cells. ADSCs-derived proteins improve hair growth and protect human dermal papilla cells against cytotoxic injury caused by androgen and reactive oxygen species...
August 29, 2017: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28865317/photoprotection-against-uv-induced-damage-by-skin-derived-precursors-in-hairless-mice
#19
Dehai Xian, Xiaoqing Gao, Xia Xiong, Jixiang Xu, Lingyu Yang, Lun Pan, Jianqiao Zhong
BACKGROUND: Skin photodamage is associated with UV-induced overproduction of reactive oxygen species (ROS) and the inactivation of NF-E2-related factor 2 (Nrf2). Skin-derived precursor cells (SKPs), a population of dermal stem cells, are considered to be involved in wound repair and skin regeneration through the activation of Nrf2. However, no reports concentrate on the treatment of skin photodamage with SKPs. OBJECTIVE: To investigate the photoprotective role of SKPs against UV-induced damage in mice...
August 23, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28833447/psoriasis-or-not-review-of-51-clinically-confirmed-cases-reveals-an-expanded-histopathologic-spectrum-of-psoriasis
#20
Thinh Chau, Kory K Parsi, Toru Ogawa, Maija Kiuru, Thomas Konia, Chin-Shang Li, Maxwell A Fung
BACKGROUND: Psoriasis is usually diagnosed clinically, so only non-classic or refractory cases tend to be biopsied. Diagnostic uncertainty persists when dermatopathologists encounter features regarded as non-classic for psoriasis. OBJECTIVE: Define and document classic and non-classic histologic features in skin biopsies from patients with clinically confirmed psoriasis. METHODS: Minimal clinical diagnostic criteria were informally validated and applied to a consecutive series of biopsies histologically consistent with psoriasis...
August 22, 2017: Journal of Cutaneous Pathology
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