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Dermal papilla

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https://www.readbyqxmd.com/read/29787625/a-bald-statement-current-approaches-to-manipulate-miniaturisation-focus-only-on-promoting-hair-growth
#1
Nikolaos Pantelireis, Claire A Higgins
Hair plays a large part in communication and society with its role changing through time and across cultures. Most people don't leave the house before combing their hair or shaving their beard and for many hair loss or irregular hair growth can have a significant impact on their psychological health. Somewhat unsurprisingly, according to GMR Data today's global hair care industry is worth an estimated $87 Billion in 2018, with hair loss estimated at $2.8 Billion. Considering that no current hair loss related products can completely reverse hair loss, it is reasonable to believe this market could expand significantly with the discovery of a comprehensive therapy...
May 22, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29771334/%C3%AE-catenin-activation-in-hair-follicle-dermal-stem-cells-induces-ectopic-hair-outgrowth-and-skin-fibrosis
#2
Yixin Tao, Qingchun Yang, Lei Wang, Jie Zhang, Xuming Zhu, Qianqian Sun, Yunbin Han, Qian Luo, Yushu Wang, Xizhi Guo, Ji Wu, Baojie Li, Xiao Yang, Lin He, Gang Ma
Hair follicle dermal sheath (DS) harbors hair follicle dermal stem cells (hfDSCs), which can be recruited to replenish DS and dermal papilla (DP). Cultured DS cells can differentiate into various cell lineages in vitro. However, it is unclear how its plasticity is modulated in vivo. Wnt/β-catenin signaling plays an important role in maintaining stem cells of various lineages and is required for HF development and regeneration. Here we report that activation of β-catenin in DS generates ectopic HF outgrowth (EF) by reprogramming HF epidermal cells and DS cells themselves, and endows DS cells with hair inducing ability...
May 16, 2018: Journal of Molecular Cell Biology
https://www.readbyqxmd.com/read/29765966/further-clinical-evidence-for-the-effect-of-igf-1-on-hair-growth-and-alopecia
#3
Ralph M Trüeb
Observations on the Laron syndrome originally offered the opportunity to explore the effect of insulin-like growth factor 1 (IGF-1) deficiency on human hair growth and differentiation. According to its expression in the dermal hair papilla, IGF-1 is likely involved in reciprocal signaling. It has been shown to affect follicular proliferation, tissue remodeling, and the hair growth cycle, as well as follicular differentiation, identifying IGF-1 signaling as an important mitogenic and morphogenetic regulator in hair follicle biology...
April 2018: Skin Appendage Disorders
https://www.readbyqxmd.com/read/29761053/nature-derived-lignan-compound-vb-1-exerts-hair-growth-promoting-effects-by-augmenting-wnt-%C3%AE-catenin-signaling-in-human-dermal-papilla-cells
#4
Jieshu Luo, Mengting Chen, Yingzi Liu, Hongfu Xie, Jian Yuan, Yingjun Zhou, Jinsong Ding, Zhili Deng, Ji Li
Background: Vitexin is a kind of lignan compound which has been shown to possess a variety of pharmacological effects, such as anti-inflammatory, anti-oxidative and anti-cancer activities. However the effect of vitexin on hair regeneration has not been elaborated. Methods: The proliferation of human dermal papilla cells (hDPCs) was examined by cell counting and continuous cell culture after vitexin compound 1 (VB-1) was treated. The expression of lef1 , wnt5a , bmp2 , bmp4 , alpl and vcan was examined by RT-PCR...
2018: PeerJ
https://www.readbyqxmd.com/read/29760984/the-value-of-ultrahigh-resolution-oct-in-dermatology-delineating-the-dermo-epidermal-junction-capillaries-in-the-dermal-papillae-and-vellus-hairs
#5
Niels Møller Israelsen, Michael Maria, Mette Mogensen, Sophie Bojesen, Mikkel Jensen, Merete Haedersdal, Adrian Podoleanu, Ole Bang
Optical coherence tomography (OCT) imaging of the skin is gaining recognition and is increasingly applied to dermatological research. A key dermatological parameter inferred from an OCT image is the epidermal (Ep) thickness as a thickened Ep can be an indicator of a skin disease. Agreement in the literature on the signal characters of Ep and the subjacent skin layer, the dermis (D), is evident. Ambiguities of the OCT signal interpretation in the literature is however seen for the transition region between the Ep and D, which from histology is known as the dermo-epidermal junction (DEJ); a distinct junction comprised of the lower surface of a single cell layer in epidermis (the stratum basale) connected to an even thinner membrane (the basement membrane)...
May 1, 2018: Biomedical Optics Express
https://www.readbyqxmd.com/read/29760951/molecular-functional-analyses-revealed-essential-roles-of-hsp90-and-lamin-a-c-in-growth-migration-and-self-aggregation-of-dermal-papilla-cells
#6
Kanchalit Thanomkitti, Kedsarin Fong-Ngern, Kanyarat Sueksakit, Rattapon Thuangtong, Visith Thongboonkerd
Previous expression study using quantitative proteomics has shown that immune-mediated pathway may not be the main mechanism inducing alopecia areata (AA). Nevertheless, functional impact of such expression data set remained unknown and unexplored. This study thus aimed to define potentially novel mechanisms of the AA pathogenesis by functional investigations of the differentially expressed proteins previously identified from lesional biopsies. From 122 altered proteins, protein-protein interactions network analysis revealed that downregulated heat shock protein 90 (HSP90) and lamin A/C served as the central nodes of protein-protein interactions involving in several crucial biological functions, including cytoskeleton organization, extracellular matrix organization, and tissue development...
2018: Cell Death Discovery
https://www.readbyqxmd.com/read/29738529/identifying-novel-strategies-for-treating-human-hair-loss-disorders-cyclosporine-a-suppresses-the-wnt-inhibitor-sfrp1-in-the-dermal-papilla-of-human-scalp-hair-follicles
#7
Nathan J Hawkshaw, Jonathan A Hardman, Iain S Haslam, Asim Shahmalak, Amos Gilhar, Xinhong Lim, Ralf Paus
Hair growth disorders often carry a major psychological burden. Therefore, more effective human hair growth-modulatory agents urgently need to be developed. Here, we used the hypertrichosis-inducing immunosuppressant, Cyclosporine A (CsA), as a lead compound to identify new hair growth-promoting molecular targets. Through microarray analysis we identified the Wnt inhibitor, secreted frizzled related protein 1 (SFRP1), as being down-regulated in the dermal papilla (DP) of CsA-treated human scalp hair follicles (HFs) ex vivo...
May 2018: PLoS Biology
https://www.readbyqxmd.com/read/29724581/reversal-of-the-hair-loss-phenotype-by-modulating-the-estradiol-angpt2-axis-in-the-mouse-model-of-female-pattern-hair-loss
#8
Yujiro Endo, Yuko Obayashi, Tomoji Ono, Tetsushi Serizawa, Michiaki Murakoshi, Manabu Ohyama
BACKGROUND: Despite high demand for a remedy, the treatment options for female pattern hair loss (FPHL) are limited. FPHL is frequent in postmenopausal women. In ovariectomized (OVX) mice, which lack β-estradiol (E2) and manifest hair loss mimicking FPHL, E2 supplementation has been shown to increase hair density. However, the mechanism by which E2 exhibits its biological activity remains elusive. OBJECTIVE: To identify the downstream targets of E2 in the context of FPHL pathophysiology and discover a potential therapeutic agent for the E2-dependent subtype of FPHL...
April 6, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29691589/gene-expression-profiling-of-the-intact-dermal-sheath-cup-of-human-hair-follicles
#9
Shiro Niiyama, Yumiko Ishimatsu-Tsuji, Yosuke Nakazawa, Yuzo Yoshida, Tsutomu Soma, Ritsuro Ideta, Hideki Mukai, Jiro Kishimoto
Cells that constitute the dermal papillae of hair follicles might be derived from the dermal sheath, the peribulbar component of which is the dermal sheath cup. The dermal sheath cup is thought to include the progenitor cells of the dermal papillae and possesses hair inductive potential; however, it has not yet been well characterized. This study investigated the gene expression profile of the intact dermal sheath cup, and identified dermal sheath cup signature genes, including extracellular matrix components and BMP-binding molecules, as well as TGF-b1 as an upstream regulator...
April 24, 2018: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/29687797/impact-of-substrate-stiffness-on-dermal-papilla-aggregates-in-microgels
#10
Justin J Y Tan, Jie Kai Tee, Keat Onn Chou, Shi Ya Au Yong, Jing Pan, Han Kiat Ho, Paul C L Ho, Lifeng Kang
Interaction between cells and the extracellular environment plays a vital role in cellular development. The mechanical property of a 3-dimensional (3D) culture can be modified to mimic in vivo conditions. Dermal papilla (DP) cells are shown to gradually lose their inductivity in hair cycle development in a 2-dimensional culture. They are shown to partially restore their inductivity when transferred into a 3D microenvironment. In this study, a microarray fabricated from three different concentrations of poly-ethylene-glycol-diacrylate 3500, namely 5%, 10% and 15% w/v, yielded increasing substrate stiffness...
April 24, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29678305/the-effect-of-cilostazol-a-phosphodiesterase-3-pde3-inhibitor-on-human-hair-growth-with-the-dual-promoting-mechanisms
#11
Hye-In Choi, Dong Young Kim, Soon-Jin Choi, Chang-Yup Shin, Sungjoo Tommy Hwang, Kyu Han Kim, Ohsang Kwon
BACKGROUND: Cilostazol, a phosphodiesterase 3 (PDE3) inhibitor, increases the intracellular level of cyclic adenosine monophosphate to cause vasodilation. Topical application of cilostazol is reported to improve local blood flow and enhance wound healing; however, its effect on human hair follicles is unknown. OBJECTIVE: The purpose of this study was to determine the effect of cilostazol on hair growth. METHODS: We investigated the expression of PDE3 in human dermal papilla cells (DPCs), outer root sheath cells (ORSCs), and hair follicles...
April 11, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29615099/multimodal-label-free-imaging-of-living-dermal-equivalents-including-dermal-papilla-cells
#12
Aleksandra V Meleshina, Olga S Rogovaya, Varvara V Dudenkova, Marina A Sirotkina, Maria M Lukina, Alena S Bystrova, Victoria G Krut, Daria S Kuznetsova, Ekaterina P Kalabusheva, Andrey V Vasiliev, Ekaterina A Vorotelyak, Elena V Zagaynova
BACKGROUND: Despite the significant progress in the development of skin equivalents (SEs), the problem of noninvasively assessing the quality of the cell components and the collagen structure of living SEs both before and after transplantation remains. Undoubted preference is given to in vivo methods of noninvasive, label-free monitoring of the state of the SEs. Optical bioimaging methods, such as cross-polarization optical coherence tomography (CP OCT), multiphoton tomography (MPT), and fluorescence lifetime imaging microscopy (FLIM), present particular advantages for the visualization of such SEs...
April 3, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29605938/establishment-of-dermal-sheath-cell-line-from-cashmere-goat-and-characterizing-cytokeratin-13-as-its-novel-biomarker
#13
Bing Zhu, Zhili Guo, Muzi Jin, Yujuan Bai, Wenliang Yang, Lihua Hui
OBJECTIVE: To establish a dermal sheath cell line, a dermal papilla cell line and a outer root sheath cell line from Cashmere goat and clarify the similarities and differences among them. RESULTS: We established a dermal sheath cell line, a dermal papilla cell line and a outer root sheath cell line from the pelage skin hair follicles of Cashmere goat. The growth rate of dermal sheath cells was intermediate between that of dermal papilla cells and outer root sheath cells...
March 31, 2018: Biotechnology Letters
https://www.readbyqxmd.com/read/29583066/naturally-occurring-hair-growth-peptide-water-soluble-chicken-egg-yolk-peptides-stimulate-hair-growth-through-induction-of-vascular-endothelial-growth-factor-production
#14
Toshio Nakamura, Haruo Yamamura, Kyungho Park, Caroline Pereira, Yoshikazu Uchida, Noriko Horie, Mujo Kim, Satoshi Itami
Alopecia is divided into two categories: androgenic alopecia and nonandrogenic alopecia. An androgen-dependent abnormality of biological functions causes alopecia in males, but the role of androgens is not yet elucidated in female pattern hair loss (FPHL). Modulation of androgenic activity is not effective in certain kinds of androgenic alopecia in females, as well as in cases of nonandrogenic alopecia in males and females. The hair growth drug, minoxidil, stimulates vascular endothelial growth factor (VEGF) production as well as vascularization and hair growth in females...
March 27, 2018: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29581745/rat-vibrissa-dermal-papilla-cells-promote-healing-of-spinal-cord-injury-following-transplantation
#15
Meiying Li, Xianglin Mei, Shuang Lv, Zechuan Zhang, Jinying Xu, Dongjie Sun, Jiayi Xu, Xia He, Guangfan Chi, Yulin Li
Bone marrow mesenchymal stem cell (BMSC) transplantation is effective for repairing spinal cord injuries (SCIs); however, there are limitations of clinical BMSC applications. Previously, we reported that dermal papilla cells (DPCs) secrete brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor more actively than BMSCs. To analyze the therapeutic function of DPCs in SCI, primary DPCs and BMSCs were cultured from the same green fluorescence protein-transgenic rat. The cells were suspended in rat-tail collagen I and transplanted separately into completely transected spinal cord lesion sites...
April 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29572803/nerve-growth-and-interaction-in-gelfoam-%C3%A2-histoculture-a-nervous-system-organoid
#16
Robert M Hoffman, Sumiyuki Mii, Jennifer Duong, Yasuyuki Amoh
Nestin-expressing hair follicle-associated pluripotent (HAP) stem cells reside mainly in the bulge area (BA) of the hair follicle but also in the dermal papilla (DP). The BA appears to be origin of HAP stem cells. Long-term Gelfoam® histoculture was established of whiskers isolated from transgenic mice, in which there is nestin-driven green fluorescent protein (ND-GFP). HAP stem cells trafficked from the BA toward the DP area and extensively grew out onto Gelfoam® forming nerve-like structures. These fibers express the neuron marker β-III tubulin-positive fibers and consisted of ND-GFP-expressing cells and extended up to 500 mm from the whisker nerve stump in Gelfoam® histoculture...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29572802/hair-follicle-associated-pluripotent-hap-stem-cells-in-gelfoam-%C3%A2-histoculture-for-use-in-spinal-cord-repair
#17
Fang Liu, Robert M Hoffman
The stem cell marker, nestin, is expressed in the hair follicle, both in cells in the bulge area (BA) and the dermal papilla (DP). Nestin-expressing hair follicle-associated-pluripotent (HAP) stem cells of both the BA and DP have been previously shown to be able to form neurons, heart muscle cells, and other non-follicle cell types. The ability of the nestin-expressing HAP stem cells from the BA and DP to repair spinal cord injury was compared. Nestin-expressing HAP stem cells from both the BA and DP grew very well on Gelfoam® ...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29567388/inducing-hair-follicle-neogenesis-with-secreted-proteins-enriched-in-embryonic-skin
#18
Sabrina Mai-Yi Fan, Chia-Feng Tsai, Chien-Mei Yen, Miao-Hsia Lin, Wei-Hung Wang, Chih-Chieh Chan, Chih-Lung Chen, Kyle K L Phua, Szu-Hua Pan, Maksim V Plikus, Sung-Liang Yu, Yu-Ju Chen, Sung-Jan Lin
Organ development is a sophisticated process of self-organization. However, despite growing understanding of the developmental mechanisms, little is known about how to reactivate them postnatally for regeneration. We found that treatment of adult non-hair fibroblasts with cell-free extract from embryonic skin conferred upon them the competency to regenerate hair follicles. Proteomics analysis identified three secreted proteins enriched in the embryonic skin, apolipoprotein-A1, galectin-1 and lumican that together were essential and sufficient to induce new hair follicles...
March 13, 2018: Biomaterials
https://www.readbyqxmd.com/read/29559602/-clinical-efficacy-of-ozonated-oil-in-the-treatment-of-psoriasis-vulgaris
#19
Lina Tan, Jian Huang, Jing Lu, Jianyun Lu
To compare the efficacy and safety between ozonated oil and compound flumethasone ointment in the treatment of psoriasis vulgaris.
 Methods: A left/right self-controlled, parallel group study was conducted. Forty patients with stable psoriasis vulgaris were enrolled in the study, whose lesions were symmetrical and involvement areas were <30% body surface. The patients were divided into 2 groups. Patients with left lesions served as a test group were treated daily for ozonated oil twice, and patients with right lesions served as a control group were treated daily for compound flumetasone ointment twice...
February 28, 2018: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/29555367/laminin-332-regulates-differentiation-of-human-interfollicular-epidermal-stem-cells
#20
Takaaki Yamada, Seiji Hasegawa, Katsuma Miyachi, Yasushi Date, Yu Inoue, Akiko Yagami, Masaru Arima, Yohei Iwata, Naoki Yamamoto, Satoru Nakata, Kayoko Matsunaga, Kazumitsu Sugiura, Hirohiko Akamatsu
Interfollicular epidermal stem cells (IFE-SCs) have self-renewal and differentiation potentials, and maintain epidermal homeostasis. Stem cells in vivo are regulated by the surrounding environment called niche to function properly, however, IFE-SC niche components are not fully understood. In order to elucidate the mechanisms of keeping epidermal homeostasis and of skin aging, and also to develop new therapeutic technologies for skin diseases, we searched for niche factors that regulate IFE-SCs. We found that laminin-332, a basement membrane component, was highly expressed at the tips of the dermal papillae, where IFE-SCs are localized, and that the stem cells by themselves expressed laminin-332...
April 2018: Mechanisms of Ageing and Development
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