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Dermal papilla

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https://www.readbyqxmd.com/read/28017829/12-chloracetyl-ppd-a-novel-dammarane-derivative-shows-anti-cancer-activity-via-delay-the-progression-of-cell-cycle-g2-m-phase-and-reactive-oxygen-species-mediate-cell-apoptosis
#1
Xu De Wang, Yuan Yuan Sun, Chen Zhao, Fan Zhi Qu, Yu Qing Zhao
(20R)-Dammarane-3β, 12β, 20, 25-tetrol (25-OH-PPD) is a ginsenoside isolated from Panax ginseng (C. A. Meyer). This compound exhibits anti-cancer activities on many human cancer cell lines. In this study, we investigated anti-cancer mechanisms of 12β-O-(L-Chloracetyl)-dammar-20(22)-ene-3β,25-diol(12-Chloracetyl-PPD), a modified 25-OH-PPD. We found that compound 12-Chloracetyl-PPD resulted in a concentration-dependent inhibition of viability in prostate, breast, and gastric cancer cells, without affecting the viability of normal cell (human gastric epithelial cell line-GES-1, hair follicle dermal papilla cell line-HHDPC and rat myocardial cell line-H9C2)...
December 22, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28011196/isolating-subpopulations-of-human-epidermal-basal-cells-based-on-polyclonal-serum-against-trypsin-resistant-cspg4-epitopes
#2
Anders Patrik Gunnarsson, Rikke Christensen, Jeppe Praetorius, Uffe Birk Jensen
Chondroitin sulfate proteoglycan 4 (CSPG4) is highly expressed by human epidermal keratinocytes located at the tip of the dermal papilla where keratinocytes show characteristics of stem cells. However, since available antibodies to CSPG4 are directed against trypsin-sensitive epitopes we have been unable to study these keratinocytes isolated directly from skin samples by flow cytometry. By choosing epitopes of CSPG4 relatively close to the cell membrane we were able to generate a polyclonal antibody that successfully detects CSPG4 on keratinocytes after trypsinization...
December 21, 2016: Experimental Cell Research
https://www.readbyqxmd.com/read/28006803/-i-bythaelurus-i-i-bachi-i-n-sp-a-new-deep-water-catshark-carcharhiniformes-%C3%A2-scyliorhinidae-from-the-southwestern-indian-ocean-with-a-review-of-i-bythaelurus-i-species-and-a-key-to-their-identification
#3
Simon Weigmann, David A Ebert, Paul J Clerkin, Matthias F W Stehmann, Gavin J P Naylor
A new deep-water catshark, Bythaelurus bachi, is described based on 44 specimens caught on the southern Madagascar Ridge in the southwestern Indian Ocean. The new species is the only stout-bodied Bythaelurus with oral papillae in the region and is distinguished from all congeners by the plain beige to light gray-brown coloration, high diversity in dermal denticle morphology, and presence of composite oral papillae. Despite resemblance in body shape, Bythaelurus bachi n. sp. is distinguished from its closest congener, B...
December 19, 2016: Zootaxa
https://www.readbyqxmd.com/read/27974920/oxidative-stress-in-androgenetic-alopecia
#4
REVIEW
B E Prie, L Iosif, I Tivig, I Stoian, C Giurcaneanu
: Rationale:Androgenetic alopecia is not considered a life threatening disease but can have serious impacts on the patient's psychosocial life. Genetic, hormonal, and environmental factors are considered responsible for the presence of androgenetic alopecia. Recent literature reports have proved the presence of inflammation and also of oxidative stress at the level of dermal papilla cells of patients with androgenetic alopecia Objective:We have considered of interest to measure the oxidative stress parameters in the blood of patients with androgenetic alopecia Methods and results:27 patients with androgenetic alopecia and 25 age-matched controls were enrolled in the study...
January 2016: Journal of Medicine and Life
https://www.readbyqxmd.com/read/27974900/the-hair-growth-promoting-effect-of-rumex-japonicus-houtt-extract
#5
Hyunkyoung Lee, Na-Hyun Kim, Hyeryeon Yang, Seong Kyeong Bae, Yunwi Heo, Indu Choudhary, Young Chul Kwon, Jae Kuk Byun, Hyeong Jun Yim, Byung Seung Noh, Jeong-Doo Heo, Euikyung Kim, Changkeun Kang
Rumex japonicus Houtt. is traditionally used as a medicinal plant to treat patients suffering from skin disease in Korea. However, the beneficial effect of Rumex japonicus Houtt. on hair growth has not been thoroughly examined. Therefore, the present study aims to investigate the hair growth-promoting effect of Rumex japonicus (RJ) Houtt. root extract using human dermal papilla cells (DPCs), HaCaT cells, and C57BL/6 mice model. RJ induced antiapoptotic and proliferative effects on DPCs and HaCaT cells by increasing Bcl-2/Bax ratio and activating cellular proliferation-related proteins, ERK and Akt...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27922680/identification-of-key-genes-induced-by-platelet-rich-plasma-in-human-dermal-papilla-cells-using-bioinformatics-methods
#6
Haiyan Shen, Hanxiao Cheng, Haihua Chen, Jufang Zhang
Dermal papilla cells (DPCs) are located at the base of hair follicles, and are known to induce hair follicle regeneration. Platelet-rich plasma (PRP) functions in hair follicle regeneration. To investigate the influence of PRP on DPCs, the present study analyzed RNA‑seq data of human hair dermal papilla cells (HHDPCs) that were treated or untreated by PRP. The data included in the RNA‑seq were from two normal and two treated HHDPC samples. Following identification by Cuffdiff software, differentially expressed genes (DEGs) underwent enrichment analyses, and protein-protein interaction networks were constructed using Cytoscape software...
January 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27907131/itraq-based-quantitative-proteomic-comparison-of-early-and-late-passage-human-dermal-papilla-cell-secretome-in-relation-to-inducing-hair-follicle-regeneration
#7
Huan Zhang, Ning-Xia Zhu, Keng Huang, Bo-Zhi Cai, Yang Zeng, Yan-Ming Xu, Yang Liu, Yan-Ping Yuan, Chang-Min Lin
Alopecia is an exceedingly prevalent problem that lacks effective therapy. Recently, research has focused on early-passage dermal papilla cells (DPCs), which have hair inducing activity both in vivo and in vitro. Our previous study indicated that factors secreted from early-passage DPCs contribute to hair follicle (HF) regeneration. To identify which factors are responsible for HF regeneration and why late-passage DPCs lose this potential, we collected 48-h-culture medium (CM) from both of passage 3 and 9 DPCs, and subcutaneously injected the DPC-CM into NU/NU mice...
2016: PloS One
https://www.readbyqxmd.com/read/27848170/vegas-verruciform-genital-associated-xanthoma-a-comprehensive-literature-review
#8
REVIEW
Katherine M Stiff, Philip R Cohen
INTRODUCTION: Verruciform xanthoma is a wart-like benign lesion. The classic histologic appearance consists of foamy histiocytes within elongated dermal papillae and epithelial acanthosis. The lesion most commonly occurs in the oral cavity, but has been reported in extra-oral sites such as the penis, scrotum, and vulva. The clinical and histologic characteristics of verruciform genital-associated (Vegas) xanthomas of the penis, scrotum, and vulva are reviewed. METHODS: PubMed was used to search the following term: verruciform xanthoma...
November 15, 2016: Dermatology and Therapy
https://www.readbyqxmd.com/read/27837338/analysis-of-debrided-and-non-debrided-invasive-squamous-cell-carcinoma-skin-lesions-by-in-vivo-reflectance-confocal-microscopy-before-and-after-therapy
#9
Wenzhong Xiang, Jianzhong Peng, Xiuzu Song, Aie Xu, Zhigang Bi
Hyperkeratosis hinders the application of reflectance confocal microscopy (RCM) to image squamous cell carcinoma (SCC). Not all lesions with SCC show hyperkeratosis, and these lesions can be directly imaged. However, lesions with hyperkeratosis can be treated by debriding the hyperkeratotic surface for further imaging. RCM was used to investigate patients with suspected SCC. Lesions without obvious keratosis underwent direct RCM examinations. Lesions with obvious keratosis were treated by debriding the hyperkeratotic surface...
January 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/27795451/3-deoxysappanchalcone-promotes-proliferation-of-human-hair-follicle-dermal-papilla-cells-and-hair-growth-in-c57bl-6-mice-by-modulating-wnt-%C3%AE-catenin-and-stat-signaling
#10
Young Eun Kim, Hyung Chul Choi, In-Chul Lee, Dong Yeon Yuk, Hyosung Lee, Bu Young Choi
3-Deoxysappanchalcone (3-DSC) has been reported to possess anti-allergic, antiviral, anti-inflammatory and antioxidant activities. In the present study, we investigated the effects of 3-DSC on the proliferation of human hair follicle dermal papilla cells (HDPCs) and mouse hair growth in vivo. A real-time cell analyzer system, luciferase assay, Western blot and real-time polymerase chain reaction (PCR) were employed to measure the biochemical changes occurring in HDPCs in response to 3-DSC treatment. The effect of 3-DSC on hair growth in C57BL/6 mice was also examined...
November 1, 2016: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/27782310/reflectance-confocal-microscopy-for-the-evaluation-of-sensitive-skin
#11
Y-F Ma, C Yuan, W-C Jiang, X-L Wang, P Humbert
BACKGROUND: Nowadays, the diagnosis for sensitive skin relies on subjective assessment or on the combination of subjective and objective evaluation. No quantitative evaluation is available. It could be expected that confocal microscopy imaging could be of interest to better define the condition. METHODS: Total 166 healthy female subjects were recruited in this study. Firstly, all subjects completed the sensitive questionnaire. Then, the cutaneous structures were measured by the reflectance confocal microscopy (RCM) on the face and fossa cubitalia...
October 26, 2016: Skin Research and Technology
https://www.readbyqxmd.com/read/27772548/jak-stat-signaling-jump-starts-the-hair-cycle
#12
Etienne Wang, Sivan Harel, Angela M Christiano
Legrand et al show that JAK/STAT5 signaling in the dermal papilla is required for anagen onset in the murine hair cycle. Interestingly, others have shown that JAK-inhibition is able to induce telogen-to-anagen transition in wild-type mice. This apparent contradiction highlights the complexity of interactions within the hair follicle, and encourages further discussion on the role of JAK-STAT signaling in the various stem cell niches of the hair follicle.
November 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/27769713/androgens-modify-wnt-agonists-antagonists-expression-balance-in-dermal-papilla-cells-preventing-hair-follicle-stem-cell-differentiation-in-androgenetic-alopecia
#13
Gustavo José Leirós, Julieta María Ceruti, María Lía Castellanos, Ana Gabriela Kusinsky, María Eugenia Balañá
In androgenetic alopecia, androgens impair dermal papilla-induced hair follicle stem cell (HFSC) differentiation inhibiting Wnt signaling. Wnt agonists/antagonists balance was analyzed after dihydrotestosterone (DHT) stimulation in androgen-sensitive dermal papilla cells (DPC) cultured as spheroids or monolayer. In both culture conditions, DHT stimulation downregulated Wnt5a and Wnt10b mRNA while the Wnt antagonist Dkk-1 was upregulated. Notably, tissue architecture of DPC-spheroids lowers Dkk-1 and enhances Wnt agonists' basal expression; probably contributing to DPC inductivity...
January 5, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/27765088/-effects-of-local-transplantation-of-autologous-adipose-derived-mesenchymal-stem-cells-on-the-formation-of-hyperplastic-scar-on-rabbit-ears
#14
L Chen, D L Wang, Z R Wei, B Wang, J P Qi, G F Sun
Objective: To investigate the effects of local transplantation of autologous adipose-derived mesenchymal stem cells (ADSCs) on the formation of hyperplastic scar on rabbit ears. Methods: ADSCs were isolated from inguinal fat of six New Zealand rabbits and then sub-cultured. ADSCs of the third passage of each rabbit were used in the following experiments. Six full-thickness skin defect wounds with diameter of 6 mm on the ventral surface of every rabbit ear were made. Wound healing and local-tissue proliferation were observed, and complete epithelization time of wounds and formation time of hyperplastic scar were recorded...
October 20, 2016: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/27764761/human-platelet-lysate-versus-minoxidil-stimulates-hair-growth-by-activating-anagen-promoting-signaling-pathways
#15
Maryam Dastan, Nowruz Najafzadeh, Ali Abedelahi, Mohammadreza Sarvi, Ali Niapour
Minoxidil and human platelet lysate (HPL) are commonly used to treat patients with hair loss. However, the roles of HPL versus minoxidil in hair follicle biology largely remain unknown. Here, we hypothesized that bulge and dermal papilla (DP) cells may express specific genes, including Kras, Erk, Akt, Shh and β-catenin after exposure to minoxidil or HPL. The mouse hair follicles were isolated on day 10 after depilation and bulge or DP regions were dissected. The bulge and DP cells were cultured for 14days in DMEM/F12 medium...
December 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27746657/poor-capability-of-3d-cultured-adipose-derived-stem-cells-to-induce-hair-follicles-in-contrast-to-3d-cultured-dermal-papilla-cells
#16
Chang Hoon Seo, Mi Hee Kwack, Soo-Hong Lee, Moon Kyu Kim, Jung Chul Kim, Young Kwan Sung
No abstract text is available yet for this article.
October 2016: Annals of Dermatology
https://www.readbyqxmd.com/read/27746640/acute-stress-induced-changes-in-follicular-dermal-papilla-cells-and-mobilization-of-mast-cells-implications-for-hair-growth
#17
Hyoseung Shin, Soon-Jin Choi, A-Ri Cho, Dong Young Kim, Kyu Han Kim, Ohsang Kwon
BACKGROUND: Stress is a known cause of hair loss in many species. OBJECTIVE: In this study, we investigated the role of acute stress on hair growth using a rat model. METHODS: Rats were immobilized for 24 hours and blood samples, and skin biopsies were taken. The effect of stress-serum on the in vitro proliferation of rat and human dermal papilla cells (hDPCs), as well as serum cortisol and corticotropin-releasing hormone levels, were measured...
October 2016: Annals of Dermatology
https://www.readbyqxmd.com/read/27726200/activin-a-induced-signaling-controls-hair-follicle-neogenesis
#18
Chang Hoon Seo, Mi Hee Kwack, Moon Kyu Kim, Jung Chul Kim, Young Kwan Sung
Acquisition of potent human dermal papilla (DP) cells that can induce hair follicle neogenesis is an overarching concern and various approaches have been tried. In an attempt to solve the problem, we previously introduced the three-dimensional (3D) culture of human DP cells and observed de novo formation of hair follicles when conducting a patch hair reconstitution assay using 3D-cultured DP spheres with mouse epidermal cells. In this study, we have subsequently focused our attention on activin A, one of the notably up-regulated proteins in DP spheres compared with 2D-cultured DP cells...
October 10, 2016: Experimental Dermatology
https://www.readbyqxmd.com/read/27679975/multifaceted-role-of-hair-follicle-dermal-cells-in-bioengineered-skins
#19
C A Higgins, M Roger, R Hill, A S Ali-Khan, J Garlick, A M Christiano, C A B Jahoda
BACKGROUND: The method to generate bioengineered skin constructs was pioneered several decades ago, and nowadays these constructs are used regularly for the treatment of severe burns and non-healing wounds. Commonly, these constructs are comprised of skin fibroblasts within a collagen scaffold, forming the skin dermis, and stratified keratinocytes overlying this, forming the skin epidermis. In the past decade there has been a surge of interest in bioengineered skins, with researchers searching for alternative cell sources, or scaffolds, from which constructs can be established, and for more biomimetic equivalents with skin appendages...
September 28, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27647656/hair-growth-promoting-effect-of-dermal-papilla-like-tissues-from-canine-adipose-derived-mesenchymal-stem-cells-through-vascular-endothelial-growth-factor
#20
Aeri Lee, Sohee Bae, Seung Hoon Lee, Oh-Kyeong Kweon, Wan Hee Kim
The purpose of this study was to investigate the protein expression pattern and the in vivo trichogenicity of dermal papilla like tissues (DPLTs) made from canine adipose-derived mesenchymal stem cells (ASCs) in athymic nude mice. Canine ASCs were isolated and cultured from adipose tissue, and differentiation was induced by culturing ASCs in dermal papilla forming media. DPLTs were embedded in collagen gel, and their structural characteristics and protein expression were evaluated by hematoxylin and eosin stain and immunohistochemistry...
September 16, 2016: Journal of Veterinary Medical Science
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