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Dermal papill

Anastasia M Konstantinova, Denisa Kacerovska, Colin J R Stewart, Peter Szepe, Jan Pitha, Miroslav Sulc, Vladimir Bencik, Michal Michal, Barbara Shideler, Katrin Kerl, Dmitry V Kazakov
The authors report 11 cases of extramammary Paget disease (EMPD), all of which also demonstrated a combination of histological changes highly reminiscent of syringocystadenocarcinoma papilliferum in situ. In addition to the classical features of EMPD, characterized by the intraepidermal spread of individually dispersed neoplastic cells with ample cytoplasm, many of which contained mucin, there were areas of acanthosis with the substitution of spinous layer keratinocytes by neoplastic cells, whereas the native basal cell layer was intact...
December 2016: American Journal of Dermatopathology
T Ohnishi, H Shiraishi, S Fukaya, T Tanaka, S Watanabe
We report three cases of verruciform xanthoma (VX) in male patients aged 82, 88 and 39 years, respectively. The clinical appearance was of a mulberry-like area consisting of small papillae, which is typical of and specific to VX, and the diagnosis were histologically confirmed in all cases. Dermoscopy revealed that each surface papilla contained linear or hairpin vessels, which were surrounded by a marginal whitish rim. These structures are thought to correspond to dilated vessels in dermal papillae and papillated acanthotic epidermis, respectively...
March 2015: Clinical and Experimental Dermatology
Dimas Suárez-Vilela, Francisco Izquierdo-García, Francisco Domínguez-Iglesias, Jose Ramón Méndez-Álvarez
We describe a case of papillated Bowen disease (PBD), associated with a clear cell atypical fibroxanthoma (CCAFXA). The epidermal lesion showed a bowenoid papillomatous growth pattern with histologic features suggestive of infection by human papilloma virus (HPV). In the dermis a neoplasm made up by spindled or polygonal cells with wide clear cytoplasm and moderate nuclear pleomorphism was found. Immunohistochemical characteristics of these two lesions were clearly different. The atypical cells of the intraepidermal proliferation were positive for AE1-AE3 anticytokeratin antibody, EMA, p16, p53 and p63...
2010: Case Reports in Dermatology
Song Lu, Tien Anh Tran, David M Jones, Dale R Meyer, Jeffrey S Ross, Hugh A Fisher, John Andrew Carlson
BACKGROUND: Lymphedema typically affects a whole limb. Rarely, lymphedema can present as a circumscribed plaque or an isolated skin tumor. OBJECTIVE: To describe the clinical and pathologic characteristics and etiologic factors of localized lymphedema. METHODS: Case-control study of skin biopsy and excision specimens histologically diagnosed with lymphedema and presenting as a localized skin tumor identified during a 4-year period. RESULTS: We identified 24 cases of localized lymphedema presenting as solitary large polyps (11), solid or papillomatous plaques (7), pendulous swellings (4), or tumors mimicking sarcoma (2)...
January 2009: Journal of Cutaneous Pathology
Kevin J McElwee, Sabine Kissling, Elke Wenzel, Andrea Huth, Rolf Hoffmann
Green fluorescent protein (GFP)-expressing wild-type, and nontransgenic mouse vibrissa follicle cells were cultured and implanted to mouse ears and footpads. Dermal papiller (DP)-derived cells and cells from the peribulbar dermal sheath "cup" (DSC) induced new hair follicles in both implanted ears and footpads, while nonbulbar dermal sheath cells did not. Confocal microscopy revealed that GFP-expressing DP and DSC cells induced hair growth associated with the formation of DP exclusively comprised of fluorescent cells...
December 2003: Journal of Investigative Dermatology
R R Maronpot, L G Peterson
The spontaneous occurrence of nephritis and resultant mortality was investigated among 2,836 control or treated (dermal carcinogenesis bioassays) C3H/HeJ male mice. Overall incidence of nephritis putatively caused by Proteus mirabilis was 1.2%. Incidences were similar in control and treated mice and ranged from 2.5--32.5% among 73 unrelated treatment or control groups. Diagnosis was based upon characteristic gross or histologic renal lesions. Grossly affected kidneys contained either multiple, discrete tan foci or elevated pale tan patches...
December 1981: Laboratory Animal Science
B B Gokhale, L N Mehta
A histological study of 74 vitiligo cases revealed inflammatory and degenerative changes in the epidermis, papillation, blood vessels, sweat glands and ducts, sebaceous glands and hair follicles, dermis (connective tissue), and dermal nerves and nerve endings.
October 1983: International Journal of Dermatology
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