keyword
MENU ▼
Read by QxMD icon Read
search

Profile keratitis

keyword
https://www.readbyqxmd.com/read/29111996/microbial-keratitis-after-accelerated-corneal-collagen-cross-linking-in-keratoconus
#1
Prafulla K Maharana, Pranita Sahay, M Sujeeth, Deepali Singhal, Anubha Rathi, Jeewan S Titiyal, Namrata Sharma
PURPOSE: To assess the pattern of microbial keratitis after accelerated corneal collagen cross-linkage (aCXL) in patients with keratoconus. METHOD: The medical records of cases of keratoconus that underwent aCXL from June 2014 to May 2017 were reviewed. Cases that developed microbial keratitis after aCXL were included in the study. The clinical, microbiological profile and the treatment outcomes were evaluated. RESULTS: Of 532 eyes that underwent aCXL, 7 cases developed microbial keratitis during the study period...
November 2, 2017: Cornea
https://www.readbyqxmd.com/read/29077941/safety-pharmacokinetics-and-antitumor-response-of-depatuxizumab-mafodotin-as-monotherapy-or-in-combination-with-temozolomide-in-patients-with-glioblastoma
#2
Hui K Gan, David A Reardon, Andrew B Lassman, Ryan Merrell, Martin van den Bent, Nicholas Butowski, Zarnie Lwin, Helen Wheeler, Lisa Fichtel, Andrew M Scott, Erica J Gomez, JuDee Fischer, Helen Mandich, Hao Xiong, Ho-Jin Lee, Wijith P Munasinghe, Lisa A Roberts-Rapp, Peter J Ansell, Kyle D Holen, Priya Kumthekar
Background: We recently reported an acceptable safety and pharmacokinetic profile of depatuxizumab mafodotin (depatux-m), formerly called ABT-414, plus radiation and temozolomide in newly diagnosed glioblastoma (Arm A). The purpose of this study was to evaluate the safety and pharmacokinetics of depatux-m, either in combination with temozolomide in newly diagnosed or recurrent glioblastoma (Arm B) or as monotherapy in recurrent glioblastoma (Arm C). Methods: In this multicenter phase 1 dose escalation study, patients received depatux-m (0...
October 25, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/29072860/clinical-profile-of-herpes-zoster-ophthalmicus-in-a-south-indian-patient-population
#3
Kalpana Babu, Padmamalini Mahendradas, Bhagya Sudheer, Ankush Kawali, Deepika C Parameswarappa, Vibha Pal, Mariamma Philips
PURPOSE: To analyze and compare the clinical profile of herpes zoster ophthalmicus (HZO) patients in a South Indian patient population aged <60 years and ≥60 years and determine the risk factors for recurrence of ocular inflammation. METHODS: Retrospective study of 249 cases between 2006 and 2016 from two tertiary referral eye centres in south india. RESULTS: Out of 249 cases, 189 cases were <60 years (Group 1) and 60 cases were aged ≥60 years (Group2)...
October 26, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28993066/clinical-and-microbiological-profile-of-infectious-keratitis-in-an-area-of-madrid-spain
#4
Soraya Mediero, Ana Boto de Los Bueis, Karina Spiess, Mariana Díaz-Almirón, Almudena Del Hierro Zarzuelo, Isabel Villalaín Rodes, Adela García Perea
INTRODUCTION: To study antibiotic susceptibility in bacterial keratitis (BK), its profile over 10 years and its influence on ophthalmological practice. METHODS: Retrospective review of BK with positive corneal scraping over a 10-year period. Risk factors for keratitis, visual acuity (VA), empirical topical treatment, corneal infection characteristics and outcomes were analyzed for BK due to Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Pseudomonas aeruginosa and Propionibacterium acnes...
October 6, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/28978606/sclerokeratouveitis-and-lens-dislocation-in-a-patient-with-genital-ulcer-was-the-great-imitator-imitated
#5
Anubha Rathi, Brijesh Takkar, Namrata Sharma
Uveitis is the most common ocular manifestation of syphilis, while scleritis is rare. A case of nodular scleritis, peripheral keratitis and uveitis in a patient with genital ulcer is presented in this report. This patient had a clinical profile suggestive of syphilis, though the serology was negative for treponemal antibodies. Other possible differential diagnosis imitating syphilis are discussed.
October 4, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28903964/clinical-profile-of-pythium-keratitis-perioperative-measures-to-reduce-risk-of-recurrence
#6
Shweta Agarwal, Geetha Iyer, Bhaskar Srinivasan, Mamta Agarwal, Shobha Panchalam Sampath Kumar, Lily K Therese
PURPOSE: To report the clinical profile and role of perioperative adjunctive measures to reduce the risk of recurrence in Pythium insidiosum keratitis. METHODS: Retrospective analysis of 10 eyes of 10 patients with P. insidiosum keratitis. Diagnosis was confirmed by PCR DNA sequencing. RESULTS: 7out of 10 patients were from urban locales, and none had any obvious history of injury with vegetative matter and were being treated for fungal keratitis...
September 13, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28873175/development-of-a-poly-%C3%AE%C2%B5-lysine-contact-lens-as-a-drug-delivery-device-for-the-treatment-of-fungal-keratitis
#7
Andrew G Gallagher, Keri McLean, Rosalind M K Stewart, Don A Wellings, Heather E Allison, Rachel L Williams
Purpose: The purpose of this study was to develop a more efficient drug delivery device to overcome the limitations of current drop therapy for the treatment of fungal keratitis. Methods: Amphotericin B (AmpB), 0 to 30 μg/mL, was associated with a poly-ε-lysine (pεK) hydrogel. Fungicidal effect against Candida albicans was assessed at 18 and 42 hours by optical density (OD600) and growth on agar. Tear film dilution effect was mimicked by storage of AmpB pεK gels in 3...
September 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28844988/risk-factors-demographics-and-clinical-profile-of-acanthamoeba-keratitis-in-melbourne-an-18-year-retrospective-study
#8
Matthew Hao Lee, Robin Geoffrey Abell, Biswadev Mitra, Merv Ferdinands, Rasik B Vajpayee
PURPOSE: To assess incidence, risk factors, presentation and final visual outcome of patients with Acanthamoebakeratitis (AK) treated at the Royal Victorian Eye and Ear Hospital (RVEEH), Melbourne, Australia, over an 18-year period. METHODS: A retrospective review of all cases of AK managed at RVEEH between January 1998 and May 2016 was performed. Data collected included age, gender, affected eye, signs and symptoms, time between symptoms and diagnosis, risk factors, presenting and final visual acuity (VA), investigations, medical treatment, surgical interventions and length of follow-up...
August 27, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28837732/candida-species-from-eye-infections-drug-susceptibility-virulence-factors-and-molecular-characterization
#9
Konduri Ranjith, Bhavani Sontam, Savitri Sharma, Joveeta Joseph, Kanchana N Chathoth, Kalyana C Sama, Somasheila I Murthy, Sisinthy Shivaji
Purpose: To determine the type of Candida species in ocular infections and to investigate the relationship of antifungal susceptibility profile to virulence factors. Methods: Fifty isolates of yeast-like fungi from patients with keratitis, endophthalmitis, and orbital cellulitis were identified by Vitek-2 compact system and DNA sequencing of ITS1-5.8S-ITS2 regions of the rRNA gene, followed by phylogenetic analysis for phenotypic and genotypic identification, respectively...
August 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28813424/risk-factors-and-causative-organisms-in-microbial-keratitis-in-daily-disposable-contact-lens-wear
#10
MULTICENTER STUDY
Fiona Stapleton, Thomas Naduvilath, Lisa Keay, Cherry Radford, John Dart, Katie Edwards, Nicole Carnt, Darwin Minassian, Brien Holden
PURPOSE: This study investigated independent risk factors and causative organisms in microbial keratitis in daily disposable contact lens (CL)-wearers. METHODS: A multisite prospective case-control study was undertaken. Cases were daily disposable CL-wearers attending Moorfields Eye Hospital with microbial keratitis and those reported through a one-year surveillance study in Australia and in New Zealand. A population-based telephone survey identified daily disposable CL-wearing controls...
2017: PloS One
https://www.readbyqxmd.com/read/28755026/sensitivity-of-enzymatic-toxins-from-corneal-isolate-of-acanthamoeba-protozoan-to-physicochemical-parameters
#11
Viviane P Sant'Ana, Annette S Foronda, Denise de Freitas, Linda C Carrijo-Carvalho, Fábio Ramos de Souza Carvalho
Acanthamoeba is a free-living amoeba that causes severe corneal infection (Acanthamoeba keratitis) and produces a variety of extracellular enzymes, called exoproteome. Since physicochemical characters are suggested being associated with therapeutic profile and clinical severity of the infection, we investigated the physicochemical properties of proteolysis mediated by amoebic exoproteome. Corneal scraping was collected from a patient who showed typical symptoms of acute Acanthamoeba keratitis. Axenic amoeba was phylogenetically identified by 18S rDNA sequencing analysis...
November 2017: Current Microbiology
https://www.readbyqxmd.com/read/28708219/one-year-efficacy-and-safety-of-0-1-cyclosporine-a-cationic-emulsion-in-the-treatment-of-severe-dry-eye-disease
#12
Christophe Baudouin, Maite Sainz de la Maza, Mourad Amrane, Jean-Sébastien Garrigue, Dahlia Ismail, Francisco C Figueiredo, Andrea Leonardi
PURPOSE: The SANSIKA study evaluated the efficacy/safety of 0.1% (1 mg/mL) cyclosporine A cationic emulsion (CsA CE) for treating dry eye disease (DED) with severe keratitis. The double-masked phase demonstrated that CsA CE was effective in reducing corneal damage and ocular surface inflammation, and was well-tolerated over 6 months. Here we report efficacy and safety findings of SANSIKA's open-label extension (OLE). METHODS: In this multicenter, double-masked, phase III study, patients with severe DED (corneal fluorescein staining [CFS] grade 4, modified Oxford scale) were randomized to once-daily CsA CE (Ikervis®) or its vehicle for 6 months, followed by 6-month open-label, once-daily CsA CE (CsA CE/CsA CE and vehicle/CsA CE groups)...
July 1, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28632575/clinical-profile-etiology-and-outcome-of-infantile-ocular-trauma-a-developing-country-perspective
#13
Vedang D Shah, Madhu Uddaraju, Amitabh Singh, Rashmi Ranjan Das
OBJECTIVE: The aim of this article was to study the clinical profile, etiology, and outcome of infantile ocular trauma in a developing country setting. METHODS: A retrospective study on corneal trauma in infants (≤12 months old) was undertaken in a tertiary care hospital during a 2-year period. An analysis of clinical profile, etiology, microbiological profile, clinical course, and outcome was studied. RESULTS: Seventy-six infants were included...
June 20, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28631638/clinicomicrobiological-profile-of-endophthalmitis-a-10-year-experience-in-a-tertiary-care-center-in-north-india
#14
Gita Satpathy, Niranjan Nayak, Meenakshi Wadhwani, Pradeep Venkwatesh, Atul Kumar, Yograj Sharma, Vishnu Sreenivas
PURPOSE: To determine the clinicomicrobiological profile of infectious agents and their antibiotic susceptibility in different type of endophthalmitis. METHODS: A retrospective review of clinical and microbiological records from January 2001 to December 2010, was performed in 1110 patients diagnosed with different type of endophthalmitis (postoperative, posttraumatic, endogenous and post keratitis) to record the demographic details, clinical presentations; microbiological agents isolated with their antimicrobial sensitivity pattern...
April 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28622198/ocular-sarcoidosis-new-diagnostic-modalities-and-treatment
#15
Sung J Yang, Sherveen Salek, James T Rosenbaum
PURPOSE OF REVIEW: Ocular involvement in sarcoidosis is present in up to 80% of patients and is frequently manifested before diagnosis of the underlying systemic disease. Considering the therapeutic consequences, early diagnosis of the underlying disease is advantageous in patients presenting with ocular inflammation. There are several ocular findings suggestive of underlying sarcoidosis, such as granulomatous keratic precipitates, iris nodules, cells in the vitreous humor known as snowballs and snowbanks, and retinal periphlebitis...
September 2017: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/28573109/persistence-of-innate-immune-pathways-in-late-stage-human-bacterial-and-fungal-keratitis-results-from-a-comparative-transcriptome-analysis
#16
Jaya D Chidambaram, Shichina Kannambath, Palepu Srikanthi, Manisha Shah, Prajna Lalitha, Shanmugam Elakkiya, Julien Bauer, Namperumalsamy V Prajna, Martin J Holland, Matthew J Burton
Microbial keratitis (MK) is a major cause of blindness worldwide. Despite adequate antimicrobial treatment, tissue damage can ensue. We compared the human corneal transcriptional profile in late stage MK to normal corneal tissue to identify pathways involved in pathogenesis. Total RNA from MK tissue and normal cadaver corneas was used to determine transcriptome profiles with Illumina HumanHT-12 v4 beadchips. We performed differential expression and network analysis of genes in bacterial keratitis (BK) and fungal keratitis (FK) compared with control (C) samples...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28567072/hyperimmunoglobulin-e-syndrome-genetics-immunopathogenesis-clinical-findings-and-treatment-modalities
#17
REVIEW
Hassan Hashemi, Masoumeh Mohebbi, Shiva Mehravaran, Mehdi Mazloumi, Hamidreza Jahanbani-Ardakani, Seyed-Hossein Abtahi
The hyperimmunoglobulin E syndromes (HIESs) are very rare immunodeficiency syndromes with multisystem involvement, including immune system, skeleton, connective tissue, and dentition. HIES are characterized by the classic triad of high serum levels of immunoglobulin E (IgE), recurrent staphylococcal cold skin abscess, and recurrent pneumonia with pneumatocele formation. Most cases of HIES are sporadic although can be inherited as autosomal dominant and autosomal recessive traits. A fundamental immunologic defect in HIES is not clearly elucidated but abnormal neutrophil chemotaxis due to decreased production or secretion of interferon γ has main role in the immunopathogenesis of syndrome, also distorted Th1/Th2 cytokine profile toward a Th2 bias contributes to the impaired cellular immunity and a specific pattern of infection susceptibility as well as atopic-allergic constitution of syndrome...
2017: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/28534320/infectious-keratitis-and-orthokeratology-lens-use-a-systematic-review
#18
REVIEW
Ka Wai Kam, Wing Yung, Gabriel Ka Hin Li, Li Jia Chen, Alvin L Young
PURPOSE: Myopia is a prevalent condition among Asians. Orthokeratology lens has gained popularity as a method of myopia control. This systematic review is to summarize the clinical profile of infectious keratitis in association with orthokeratology lens wear. METHODS: We searched in the PubMed and EMBASE for articles adopting the search strategy "(orthokeratology lens OR orthokeratology) AND (bacterial eye infection OR keratitis OR cornea ulcer OR microbial keratitis OR bacterial keratitis)", from the start date of the databases to August 23, 2016...
May 22, 2017: Infection
https://www.readbyqxmd.com/read/28489721/tear-cytokine-levels-in-contact-lens-wearers-with-acanthamoeba-keratitis
#19
Nicole Carnt, Vicente M Montanez, Grazyna Galatowicz, Neyme Veli, Virginia Calder
PURPOSE: To determine differences in key tear film cytokines between mild and severe cases of acanthamoeba keratitis (AK) and control contact lens (CL) wearers. METHODS: This was a prospective study of CL wearers with AK attending Moorfields Eye Hospital and control CL wearers from the Institute of Optometry, London. Basal tear specimens were collected by 10-μL capillary tubes (BLAUBRAND intraMark, Wertheim, Germany), and tear protein levels were measured with a multiplex magnetic bead array (Luminex 100; Luminex Corporation, Austin, TX) for cytokines interleukin (IL)-1β, IL-6, IL-8, IL-10, IL-17A, IL-17E, IL-17F, IL-22, and interferon gamma and with enzyme-linked immunosorbent assay (Abcam, Cambridge, United Kingdom) for CXCL2...
July 2017: Cornea
https://www.readbyqxmd.com/read/28440955/phase-1-dose-escalation-study-of-mirvetuximab-soravtansine-imgn853-a-folate-receptor-%C3%AE-targeting-antibody-drug-conjugate-in-patients-with-solid-tumors
#20
Kathleen N Moore, Hossein Borghaei, David M O'Malley, Woondong Jeong, Shelly M Seward, Todd M Bauer, Raymond P Perez, Ursula A Matulonis, Kelli L Running, Xiaoyan Zhang, Jose F Ponte, Rodrigo Ruiz-Soto, Michael J Birrer
BACKGROUND: Mirvetuximab soravtansine (IMGN853) is an antibody-drug conjugate that selectively targets folate receptor α (FRα). In this phase 1 dose-escalation study, the authors investigated IMGN853 in patients with FRα-positive solid tumors. METHODS: Patients received IMGN853 on day 1 of a 21-day cycle (once every 3 weeks dosing), with cycles repeated until patients experienced dose-limiting toxicity or progression. Dose escalation commenced in single-patient cohorts for the first 4 planned dose levels and then followed a standard 3 + 3 scheme...
August 15, 2017: Cancer
keyword
keyword
25700
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"