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https://www.readbyqxmd.com/read/28440955/phase-1-dose-escalation-study-of-mirvetuximab-soravtansine-imgn853-a-folate-receptor-%C3%AE-targeting-antibody-drug-conjugate-in-patients-with-solid-tumors
#1
Kathleen N Moore, Hossein Borghaei, David M O'Malley, Woondong Jeong, Shelly M Seward, Todd M Bauer, Raymond P Perez, Ursula A Matulonis, Kelli L Running, Xiaoyan Zhang, Jose F Ponte, Rodrigo Ruiz-Soto, Michael J Birrer
BACKGROUND: Mirvetuximab soravtansine (IMGN853) is an antibody-drug conjugate that selectively targets folate receptor α (FRα). In this phase 1 dose-escalation study, the authors investigated IMGN853 in patients with FRα-positive solid tumors. METHODS: Patients received IMGN853 on day 1 of a 21-day cycle (once every 3 weeks dosing), with cycles repeated until patients experienced dose-limiting toxicity or progression. Dose escalation commenced in single-patient cohorts for the first 4 planned dose levels and then followed a standard 3 + 3 scheme...
April 25, 2017: Cancer
https://www.readbyqxmd.com/read/28384032/in-vitro-evaluation-of-the-ophthalmic-toxicity-profile-of-chlorhexidine-and-propamidine-isethionate-eye-drops
#2
Anxo Fernández-Ferreiro, María Santiago-Varela, María Gil-Martínez, Miguel González-Barcia, Andrea Luaces-Rodríguez, Victoria Díaz-Tome, María Pardo, José Blanco Méndez, Antonio Piñeiro-Ces, María Teresa Rodríguez-Ares, Maria Jesus Lamas, Francisco J Otero-Espinar
PURPOSE: Acanthamoeba keratitis causes frequent epithelial lesions that fully expose the corneal stroma. The aim of this study was to determine the toxic profile of chlorhexidine and propamidine eye drops. METHODS: We used primary human keratocytes in cell culture in combination with a novel technology that evaluates dynamic real-time cytotoxicity through impedance analysis. Additional studies such as a classic cell viability test (WST-1(®)), a bovine corneal opacity and permeability assay, and an irritation eye study (Hen's Egg Test [HET]) have been made...
April 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28347669/microbial-keratitis-after-penetrating-keratoplasty
#3
Jen-Pin Sun, Wei-Li Chen, Jehn-Yu Huang, Yu-Chih Hou, I-Jong Wang, Fung-Rong Hu
PURPOSE: To report the incidence, microbiological profile, graft survival and determining factors of microbial keratitis after penetrating keratoplasty (PK). DESIGN: Observational case series. METHODS: Fifty-one patients (52 eyes) who were treated at a single tertiary referral center during a 10-year period. Retrospective chart review of medical records of all patients diagnosed with microbial keratitis after penetrating keratoplasty at the National Taiwan University Hospital between January 2000 and December 2009...
March 24, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28298316/paediatric-infectious-keratitis-a-case-series-of-107-children-presenting-to-a-tertiary-referral-centre
#4
Julia Dutra Rossetto, Kara M Cavuoto, Carla J Osigian, Ta Chen Peter Chang, Darlene Miller, Hilda Capo, Oriel Spierer
BACKGROUND/AIMS: Corneal ulcers can result in severe visual impairment in children. The recent trends of paediatric microbial ulcerative keratitis in the USA are unknown. The purpose of this study is to report the risk factors, microbiological profile and treatment outcomes of paediatric microbial keratitis in South Florida. METHODS: A university-based tertiary eye care centre retrospective case series between 1992 and 2015. Medical records of 107 paediatric patients (age <18 years) with the diagnosis of microbial ulcerative keratitis were analysed...
March 15, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28228409/clinical-and-demographic-study-of-microsporidial-keratoconjunctivitis-in-south-india-a-3-year-study-2013-2015
#5
Rohan Agashe, Naveen Radhakrishnan, Sayali Pradhan, Muthiah Srinivasan, Venkatesh N Prajna, Prajna Lalitha
AIM: To study the demographic profile, clinical features, treatment outcome and ocular morbidity of smear-positive microsporidial keratoconjunctivitis. METHODS: Retrospective case series of all patients with clinical features of microsporidial keratoconjunctivitis and who were smear positive for the same on Gram stain from January 2013 to December 2015. Demographic data, predisposing factors, microbiological investigations, clinical course and visual outcome were analysed...
February 22, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28165809/ocular-ketoconazole-loaded-proniosomal-gels-formulation-ex-vivo-corneal-permeation-and-in-vivo-studies
#6
Ghada A Abdelbary, Maha M Amin, Mohamed Y Zakaria
CONTEXT: Vesicular drug carriers for ocular delivery have gained a real potential. Proniosomal gels as ocular drug carriers have been proven to be an effective way to improve bioavailability and patient compliance. OBJECTIVE: Formulation and in vitro/ex vivo/in vivo characterization of ketoconazole (KET)-loaded proniosomal gels for the treatment of ocular keratitis. MATERIALS AND METHODS: The effect of formulation variables; HLB value, type and concentration of non-ionic surfactants (Tweens, Spans, Brijs and Pluronics) with or without lecithin on the entrapment efficiency (EE%), vesicle size and in vitro KET release was evaluated...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28151861/shifting-trends-in-microbial-keratitis-following-penetrating-keratoplasty-in-taiwan
#7
Hung-Chi Chen, Chia-Yi Lee, Hung-Yu Lin, David Hui-Kang Ma, Phil Yeong-Fong Chen, Ching-Hsi Hsiao, Hsin-Chiung Lin, Lung-Kun Yeh, Hsin-Yuan Tan
To investigate the clinical and microbiological profiles from microbial keratitis following penetrating keratoplasty (PKP) in a tertiary referral center in Taiwan, the medical records of 648 consecutive patients (648 eyes) undergoing PKP between January 2003 and December 2007 were retrospectively reviewed. Patients who subsequently sustained microbial keratitis were enrolled and analyzed for potential risk factors, clinical manifestations, microbiological profiles, complications, graft survival, and final visual outcome...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28039367/efficacy-and-safety-results-of-abt-414-in-combination-with-radiation-and-temozolomide-in-newly-diagnosed-glioblastoma
#8
David A Reardon, Andrew B Lassman, Martin van den Bent, Priya Kumthekar, Ryan Merrell, Andrew M Scott, Lisa Fichtel, Erik P Sulman, Erica Gomez, JuDee Fischer, Ho-Jin Lee, Wijith Munasinghe, Hao Xiong, Helen Mandich, Lisa Roberts-Rapp, Peter Ansell, Kyle D Holen, Hui K Gan
BACKGROUND: The purpose of this study was to determine the maximum tolerated dose (MTD), recommended phase II dose (RPTD), safety, and pharmacokinetics of ABT-414 plus radiation and temozolomide in newly diagnosed glioblastoma. ABT-414 is a first-in-class, tumor-specific antibody-drug conjugate that preferentially targets tumors expressing overactive epidermal growth factor receptor (EGFR). METHODS: In this multicenter phase I study, patients received 0.5-3.2 mg/kg ABT-414 every 2 weeks by intravenous infusion...
December 29, 2016: Neuro-oncology
https://www.readbyqxmd.com/read/27994804/microbial-profile-of-corneal-ulcers-in-a-tertiary-care-hospital-in-south-india
#9
Chittur Y Ranjini, Vishnu V Waddepally
PURPOSE: To identify the prevalence and microbial profile of infectious keratitis in a tertiary eye care hospital, and to test for the in vitro antimicrobial resistance of the bacterial isolates. METHODS: A total of 312 patients presenting to a tertiary eye care hospital with infected corneal ulcer were enrolled in this study. Their socio-demographic data and risk factors were recorded. Corneal scrapings collected from the edge of the ulcer were processed for direct gram stain and KOH mount...
October 2016: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/27982205/microbiological-and-epidemiological-study-of-infectious-keratitis-in-children-and-adolescents
#10
Maria Cecilia Zorat Yu, Ana Luisa Höfling-Lima, Guilherme Henrique Campos Furtado
Purpose: To analyze epidemiological and microbiological aspects of microbial keratitis in children and adolescents. Methods: This retrospective cohort study was conducted at the Department of Ophthalmology and Visual Science, Escola Paulista de Medicina, Universidade Federal de São Paulo, between July 15, 1975, and December 31, 2010. We analyzed corneal samples from 859 patients with clinical suspicion of infectious keratitis, comparing epidemiological and microbiological characteristics of bacterial keratitis with those of non-bacterial and non-viral keratitis...
September 2016: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/27928519/antimicrobial-susceptibility-and-minimal-inhibitory-concentration-of-pseudomonas-aeruginosa-isolated-from-septic-ocular-surface-disease-in-different-animal-species
#11
L Leigue, F Montiani-Ferreira, B A Moore
The purpose of this study was to evaluate the antibiotic susceptibility profile of Pseudomonas aeruginosa isolated from different animal species with septic ocular surface disease. Sixteen strains of P. aeruginosa were isolated from different species of animals (dog, cat, horse, penguin and brown bear) with ocular surface diseases such as conjunctivitis, keratocojnuctivits sicca and ulcerative keratitis. These isolates were tested against 11 different antimicrobials agents using the Kirby-Bauer disk-diffusion method...
2016: Open veterinary journal
https://www.readbyqxmd.com/read/27872886/data-set-of-aspergillus-flavus-induced-alterations-in-tear-proteome-understanding-the-pathogen-induced-host-response-to-fungal-infection
#12
Jeyalakshmi Kandhavelu, Naveen Luke Demonte, Venkatesh Prajna Namperumalsamy, Lalitha Prajna, Chitra Thangavel, Jeya Maheshwari Jayapal, Dharmalingam Kuppamuthu
Fungal keratitis is one of the leading causes of blindness in the tropical countries affecting individuals in their most productive age. The host immune response during this infection is poorly understood. We carried out comparative tear proteome analysis of Aspergillus flavus keratitis patients and uninfected controls. Proteome was separated into glycosylated and non-glycosylated fractions using lectin column chromatography before mass spectrometry. The data revealed the major processes activated in the human host in response to fungal infection and reflected in the tear...
December 2016: Data in Brief
https://www.readbyqxmd.com/read/27867111/anti-inflammatory-activity-of-punica-granatum-l-pomegranate-rind-extracts-applied-topically-to-ex-vivo-skin
#13
David M J Houston, Joachim Bugert, Stephen P Denyer, Charles M Heard
Coadministered pomegranate rind extract (PRE) and zinc (II) produces a potent virucidal activity against Herpes simplex virus (HSV); however, HSV infections are also associated with localised inflammation and pain. Here, the objective was to determine the anti-inflammatory activity and relative depth penetration of PRE, total pomegranate tannins (TPT) and zinc (II) in skin, ex vivo. PRE, TPT and ZnSO4 were dosed onto freshly excised ex vivo porcine skin mounted in Franz diffusion cells and analysed for COX-2, as a marker for modulation of the arachidonic acid inflammation pathway, by Western blotting and immunohistochemistry...
March 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/27863549/cytokine-and-chemokine-profiles-of-aqueous-humor-and-serum-in-horses-with-uveitis-measured-using-multiplex-bead-immunoassay-analysis
#14
Elizabeth Curto, Kristen M Messenger, Jacklyn H Salmon, Brian C Gilger
OBJECTIVE: To determine whether horses with clinically diagnosed Equine Recurrent Uveitis (ERU) and those with Leptospirosis infection have a specific cytokine profile in their aqueous humor (AH) and serum that differs from horses with uveitis secondary to other ocular inflammatory processes and from horses with normal eyes. ANIMALS STUDIED: Twenty-five client-owned horses with uveitis that were presented to the North Carolina State University Ophthalmology Service, and four University-owned horses without history or clinical signs of ocular disease...
December 2016: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/27836717/therapeutic-agents-and-biocides-for-ocular-infections-by-free-living-amoebae-of-acanthamoeba-genus
#15
REVIEW
Linda Christian Carrijo-Carvalho, Viviane Peracini Sant'ana, Annette Silva Foronda, Denise de Freitas, Fabio Ramos de Souza Carvalho
Acanthamoeba keratitis is a sight-threatening infectious disease. Resistance of the cystic form of the protozoan to biocides and the potential toxicity of chemical compounds to corneal cells are the main concerns related to long-term treatment with the clinically available ophthalmic drugs. Currently, a limited number of recognized antimicrobial agents are available to treat ocular amoebic infections. Topical application of biguanide and diamidine antiseptic solutions is the first-line therapy. We consider the current challenges when treating Acanthamoeba keratitis and review the chemical properties, toxicities, and mechanisms of action of the available biocides...
March 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/27789337/aspergillus-flavus-induced-alterations-in-tear-protein-profile-reveal-pathogen-induced-host-response-to-fungal-infection
#16
Jeyalakshmi Kandhavelu, Naveen Luke Demonte, Venkatesh Prajna Namperumalsamy, Lalitha Prajna, Chitra Thangavel, Jeya Maheshwari Jayapal, Dharmalingam Kuppamuthu
Aspergillus flavus and Fusarium sp. are primary causative agents of keratitis that results in corneal tissue damage leading to vision loss particularly in individuals from the tropical parts of the world. Proteins in the tear film collected from control and keratitis patients was profiled and compared. A total of 1873 proteins from control and 1400 proteins from patient tear were identified by mass spectrometry. While 847 proteins were found to be glycosylated in the patient tear, only 726 were glycosylated in control tear...
January 30, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/27755163/epidemiology-and-outcome-of-microbial-keratitis-private-university-versus-urban-public-hospital-care
#17
David T Truong, Minh-Thuy Bui, H Dwight Cavanagh
PURPOSE: To review the epidemiology, risk factors, microbiologic spectrum, and treatment of microbial keratitis during a 5-year period at an urban public hospital in comparison with an adjacent private university practice. METHODS: Retrospective chart review in the 5-year interval, 2009 through 2014. Primary outcome measures included patient age at presentation, best-corrected visual acuity (BCVA), risk factors, culture and sensitivities, treatment, and complication occurrence...
October 7, 2016: Eye & Contact Lens
https://www.readbyqxmd.com/read/27742299/epidemiological-profile-of-patients-undergoing-urgent-corneal-transplant-in-a-referral-center-in-northeastern-brazil
#18
G K P Cruz, S B da Silva, I C de Azevedo, D P S R P Carvalho, P F Meireles, M A F Júnior, A F Vitor
BACKGROUND: The purpose of the study was to characterize the epidemiological profile and average time on the waiting list of patients undergoing an urgent corneal transplantation (CT) in a referral center in the state of Rio Grande do Norte, northeastern Brazil. METHODS: This cross-sectional study included cases of urgent corneal transplants performed in a referral center from January 2010 to December 2014. Data were collected between January and March 2015. RESULTS: Seventy-four cases of emergency CT were analyzed...
September 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27587283/a-comparative-retrospective-observational-study-of-the-clinical-and-microbiological-profiles-of-post-penetrating-keratoplasty-keratitis
#19
I-Huang Lin, Yi-Sheng Chang, Sung-Huei Tseng, Yi-Hsun Huang
Infectious keratitis after penetrating keratoplasty (PK) is a devastating condition that may result in graft failure and poor visual outcome. In this study, we retrospectively reviewed the medical records of patients who underwent PK between 2009 and 2014, and recorded those who developed infectious keratitis. We compared the predisposing factors and organisms isolated to those identified in our previous study, conducted between 1989 and 1994. The incidence of post-PK infectious keratitis decreased from 11...
September 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27541969/clinical-and-microbiological-profile-of-bacterial-microbial-keratitis-in-a-portuguese-tertiary-referral-center-where-are-we-in-2015
#20
Carla Sofia Ferreira, Luis Figueira, Nuno Moreira-Gonçalves, Raúl Moreira, Luis Torrão, Fernando Falcão-Reis
OBJECTIVES: To study the microbial profile, antibiotic susceptibility pattern, risk factors, therapeutic trends, and clinical outcomes for microbial keratitis (MK) in a tertiary health care center. METHODS: All cases with suspected bacterial keratitis that were followed at consultation from September 2007 to August 2015 were included. Microbial cultures were obtained and patients were managed following an internal protocol. RESULTS: Two hundred thirty-five patients were included, with a mean age of 50...
July 12, 2016: Eye & Contact Lens
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