keyword
https://read.qxmd.com/read/38532198/analysis-of-endoscopic-and-pathological-features-of-6961-cases-of-gastric-cancer
#21
JOURNAL ARTICLE
Junhui Lu, Qing Wang, Hezhao Zhang, Jingwei Liu, Jinnan Ren, Jing Fan, Jingwen Gong, Yue Sui, Xing Chen
Gastric cancer (GC) stage and tissue differentiation affect treatment efficacy and prognosis, highlighting the importance of understanding the risk factors that affect these parameters. Therefore, this study analyzed risk factors affecting the GC stage and differentiation and the relationships between the cancer site and the sex and age of the patient. We collected clinical data from 6961 patients with GC, including sex, age, endoscopic lesion location, and pathological differentiation. Patients were grouped based on GC stage (early or advanced), differentiation (well or poorly differentiated), and lesion site (upper stomach [cardia and fundus], middle stomach [gastric body], and lower stomach [gastric antrum])...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38532115/enhanced-epithelial-mesenchymal-transition-signatures-are-linked-with-adverse-tumor-microenvironment-angiogenesis-and-worse-survival-in-gastric-cancer
#22
JOURNAL ARTICLE
Masanori Oshi, Arya Mariam Roy, Li Yan, Sachika Kinoshita, Yuko Tamura, Takashi Kosaka, Hirotoshi Akiyama, Chikara Kunisaki, Kazuaki Takabe, Itaru Endo
Epithelial-mesenchymal transition (EMT) is a crucial mechanism that facilitates cancer cell metastasis. Despite its importance, the clinical significance of EMT in gastric cancer (GC) patients has yet to be clearly demonstrated. For gauging the extent of EMT in GC, we employed gene set variation analysis to score 807 patient samples from two large cohorts: TCGA and GSE84437. In both cohorts, EMT high GC showed a significant association with worse overall survival (hazard ratio (HR) = 1.74, p = 0...
March 26, 2024: Cancer Gene Therapy
https://read.qxmd.com/read/38532108/co-targeting-cd47-and-vegf-elicited-potent-anti-tumor-effects-in-gastric-cancer
#23
JOURNAL ARTICLE
Kaiqi Zhang, Yuan Xu, Xusheng Chang, Caili Xu, Wenjing Xue, Dan Ding, Mingming Nie, Hui Cai, Jun Xu, Lu Zhan, Jiangbo Han, Tiancai Cai, Dianwen Ju, Li Feng, Xuyao Zhang, Kai Yin
BACKGROUND: CD47, serving as an intrinsic immune checkpoint, has demonstrated efficacy as an anti-tumor target in hematologic malignancies. Nevertheless, the clinical relevance of CD47 in gastric cancer and its potential as a therapeutic target remains unclear. METHODS: The expression of CD47 in clinical gastric cancer tissues was assessed using immunohistochemistry and Western blot. Patient-derived cells were obtained from gastric cancer tissues and co-cultured with macrophages derived from human peripheral blood mononuclear cells...
March 27, 2024: Cancer Immunology, Immunotherapy: CII
https://read.qxmd.com/read/38531543/a-rare-coexistence-cutaneous-lobular-carcinoma-with-pyoderma-gangrenosum
#24
JOURNAL ARTICLE
Sarah Sutton, Kathryn Haran, Amanda Mullins, Cindy Lamerson
BACKGROUND Pyoderma gangrenosum (PG) is a neutrophilic inflammatory disease associated with inflammatory and autoimmune conditions and malignancies. Previously identified links between PG and cancer have included hematological malignancies, solid-organ tumors such as gastric adenocarcinoma, and breast cancer. While specific histologic subtypes of breast cancer such as ductal carcinoma have been associated with PG of the extremities, the literature is limited on the association between PG and cutaneous metastatic lobular carcinoma...
March 12, 2024: American Journal of Case Reports
https://read.qxmd.com/read/38531232/staging-laparoscopy-in-gastric-cancer-patients-from-a-dutch-nationwide-delphi-consensus-towards-a-standardized-protocol
#25
JOURNAL ARTICLE
Karen van der Sluis, Niels A D Guchelaar, Lianne Triemstra, Ron H J Mathijssen, Jelle P Ruurda, Bas P L Wijnhoven, Johanna W van Sandick
BACKGROUND: Staging laparoscopy is a common diagnostic tool in gastric cancer, but its performance varies widely. The aim of this study was to gain Dutch nationwide consensus regarding the indications for and execution of staging laparoscopy in patients with gastric cancer. METHODS: All surgeons in the Netherlands specialized in gastric cancer surgery (n = 52) were asked to participate in a Delphi consensus study. The study involved an initial questionnaire with a 3-point Likert scale, an online consensus meeting, and a second questionnaire using a 2-point Likert scale (agree/disagree)...
March 19, 2024: European Journal of Surgical Oncology
https://read.qxmd.com/read/38531231/long-term-outcomes-of-endoscopic-therapy-versus-surgical-resection-for-2-5%C3%A2-cm-gastric-gastrointestinal-stromal-tumors-a-population-based-comparative-study
#26
JOURNAL ARTICLE
Yixia Chai, Bitao Lin, Jun Zhong, Xiaosheng Wu, Xin Lin, Xiaoyue Ge, Jiayi Jiang, Zhenye Liang, Side Liu, Chuncai Gu
BACKGROUND: Endoscopic therapy (ET) of gastrointestinal stromal tumors (GIST) has become a viable treatment. We intended to compare long-term outcomes of ET versus surgical resection for 2-5 cm GIST using the Surveillance, Epidemiology, and End Results (SEER) database. METHODS: A multicenter retrospective study was conducted to compare the long-term outcomes of patients treated with ET and surgical resection for GIST. The multivariate Cox proportional hazards models were used to identify predictors for patients survival...
March 15, 2024: European Journal of Surgical Oncology
https://read.qxmd.com/read/38531150/discovery-of-cinnamylaldehyde-derived-mono-carbonyl-curcumin-analogs-as-anti-gastric-cancer-agents-via-suppression-of-stat3-and-akt-pathway
#27
JOURNAL ARTICLE
Xi Chen, Peiqin Zhang, Huating Zhang, Xueqiang Ma, Ye Zhang, Yajie Wu, Kaiwen Jin, Jiabing Wang, Jianzhang Wu
The structural modification of curcumin has always been a hotspot in drug development. In this paper, a class of cinnamylaldehyde-derived mono-carbonyl curcumin analogs (MCAs) with 7-carbon-links were designed and synthesized and their anticancer properties were evaluated. Through screening anti-gastric cancer activity of these compounds, H1 exhibited the strongest cytotoxic activity by inhibiting cell viability and colony formation, inducing cell cycle G2/M phase arrest in vitro (SGC-7901 and AGS gastric cancer cells)...
March 24, 2024: Bioorganic Chemistry
https://read.qxmd.com/read/38531046/experience-with-laparoscopic-and-robotic-colon-surgery-together-with-other-major-minimally-invasive-procedures-for-unrelated-pathologies
#28
JOURNAL ARTICLE
Hugo J R Bonatti
Background: Indications for combined colon surgery together with other procedures include oncologic multivisceral resections and abdominal trauma. It is unclear if combining minimally invasive (MI) colon surgery with unrelated other procedures increases the risk for complications. Patients and Methods: The surgical database from two institutions during a 10-year period was queried for combined colon surgeries together with other interventions. All open cases, combined cases performed for one pathology and MI colectomies together with a minor procedure, were excluded...
March 27, 2024: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://read.qxmd.com/read/38530746/a-review-on-the-traditional-applications-phytochemistry-and-pharmacology-of-the-genus-physochlaina-g-don
#29
JOURNAL ARTICLE
Younas Rasheed Tantray, Ishrat Jan, Irshad Mohiuddin, Preeti Gorla, Charul Anand, Jagdesh Chandra Arya, Shahnawaz Ahmad Bhat, Vijay Kumar, Shiddamallayya Nagayya, Rabinaryana Acharya
Physochlaina is a genus of flowering plants belonging to the family Solanaceae and consists of 10 species distributed in various Asian countries. The species of the genus have been traditionally used to cure a variety of illnesses due to their highly valuable medicinal properties, including cancer, asthma, cough, weakness, stomachache, diarrhea, swelling, spasms, toothache, boils, ulcers, rheumatic pain, chronic bronchitis, gastric problems, abdominal pain, palpitation, and insomnia. The species have gained significant attention due to their remarkable ethnopharmacological and ethnomedicinal significance...
March 26, 2024: Chemistry & Biodiversity
https://read.qxmd.com/read/38530538/the-impact-of-transcriptional-profiling-cadherin-family-and-therapeutic-approaches-of-gastric-cancer-a-translational-outlook-on-multi-omics-data-analysis
#30
JOURNAL ARTICLE
Huan Wang, Baomin Zhang
The classical cadherin gene has been linked to a variety of human malignancies, including gastric cancer. However, the link between cadherin genes and gastric cancer outcome is still unclear. This study used multi-omics data to examine the cadherin genes that were differentially regulated in gastric cancer. Differential expression of genes, epigenetic, molecular alterations, and protein expression analyses was conducted. Male SD rats were given N-methyl-N-nitrosourea (MNU) to induce stomach carcinoma in order to verify the activation of cadherin genes...
March 26, 2024: Applied Biochemistry and Biotechnology
https://read.qxmd.com/read/38530528/distribution-of-perigastric-station-4d-lymph-nodes-in-vascularized-gastroepiploic-lymph-node-transfer-an-anatomic-study-and-case-series
#31
JOURNAL ARTICLE
Hyokyung Yoo, Ki Yong Hong, Sally Min, Hye Seung Lee, Do-Joong Park, Yi-Suk Kim, Seong-Ho Kong, Hak Chang
BACKGROUND: Vascularized gastroepiploic lymph node transfer (VGLNT) is a well-accepted surgical treatment for restoring physiological function in chronic lymphedema. However, the inclusion of substantial lymph nodes (LNs) in the flap remains uncertain. This study aimed to identify the anatomical basis for reliable flap harvest for VGLNT. PATIENTS AND METHODS: The anatomy of perigastric station 4d LNs was studied in healthy cadavers (n = 15) and patients with early gastric cancer (EGC) (n = 27)...
March 26, 2024: Annals of Surgical Oncology
https://read.qxmd.com/read/38530439/clinical-implication-of-megestrol-acetate-in-metastatic-gastric-cancer-a-big-data-analysis-from-health-insurance-review-and-assessment-hira-database
#32
JOURNAL ARTICLE
Chang Min Lee, Jung Hun Kang, Se-Il Go
OBJECTIVE: Megestrol acetate (MA) is used to manage anorexia and cachexia in patients with advanced cancer. This study investigated the prescription patterns of MA in patients with metastatic gastric cancer, as well as evaluated its impact on survival outcomes and the incidence of venous thromboembolism (VTE). METHODS: A Health Insurance Review and Assessment (HIRA) service database was used to investigate differences in baseline characteristics, survival, and the incidence of VTE according to MA prescription patterns (i...
March 26, 2024: Supportive Care in Cancer
https://read.qxmd.com/read/38528931/integration-of-o-2-economised-tumour-targeted-photosensitive-magnetic-nanomaterials-in-the-diagnosis-and-therapy-of-gastric-cancer
#33
JOURNAL ARTICLE
JinRong Situ, Yingying Yang, Lingle Zhang, Hongzhang Yan, Yingsheng Cheng
Hypoxia in the tumour microenvironment is a major limiting factor in photodynamic therapy. The present study employed a novel O2 -economised photosensitizer, ACSN, to effectively curtail oxygen consumption by impeding the aerobic respiration of tumour cells, thereby increasing the reactive oxygen species (ROS) production in photodynamic therapy. To enhance the efficacy of photodynamic therapy, the active targeting peptide iRGD was employed to facilitate drug accumulation in the tumour tissue. Therefore, we constructed a targeted drug platform, ACSN/Fe3 O4 @MSNs-iRGD, that integrates diagnosis and treatment...
March 20, 2024: RSC Advances
https://read.qxmd.com/read/38528582/lncrna-wfdc21p-interacts-with-sec63-to-promote-gastric-cancer-malignant-behaviors-by-regulating-calcium-homeostasis-signaling-pathway
#34
JOURNAL ARTICLE
Jinyao Dong, Yongqiang Lv, Debin Meng, Ruyi Shi, Feng Li, Rui Guo, Yi Wang, Jiansheng Guo, Yanyan Zhang
BACKGROUND: Gastric cancer is currently estimated to be the fifth leading common cancer in the world, and responsible for about one million new cases and an estimated 769,000 cancer-related deaths each year. WFDC21P is long non-coding RNA and has been reported to play critical roles in serval types of cancer. Our research aims to investigate the biological effects and molecular mechanism of WFDC21P in gastric cancer. METHODS: Datasets (GSE53137, GSE58828, and GSE109476) in GEO database were used to screen differential expressed lncRNAs in gastric cancer by online GEO2R analysis tool...
March 25, 2024: Cancer Cell International
https://read.qxmd.com/read/38528532/integrated-analysis-of-disulfidptosis-related-immune-genes-signature-to-boost-the-efficacy-of-prognostic-prediction-in-gastric-cancer
#35
JOURNAL ARTICLE
Jie Li, Tian Yu, Juan Sun, Mingwei Ma, Zicheng Zheng, Yixuan He, Weiming Kang, Xin Ye
BACKGROUND: Gastric cancer (GC) remains a malignant tumor with high morbidity and mortality, accounting for approximately 1,080,000 diagnosed cases and 770,000 deaths worldwide annually. Disulfidptosis, characterized by the stress-induced abnormal accumulation of disulfide, is a recently identified form of programmed cell death. Substantial studies have demonstrated the significant influence of immune clearance on tumor progression. Therefore, we aimed to explore the intrinsic correlations between disulfidptosis and immune-related genes (IRGs) in GC, as well as the potential value of disulfidptosis-related immune genes (DRIGs) as biomarkers...
March 25, 2024: Cancer Cell International
https://read.qxmd.com/read/38528113/a-randomized-controlled-study-to-assess-the-effect-of-mosapride-citrate-on-intestinal-recovery-following-gastrectomy
#36
RANDOMIZED CONTROLLED TRIAL
Shiyeol Jun, Seyeol Oh, Ji Eun Jung, In Gyu Kwon, Sung Hoon Noh
The enhanced recovery after surgery (ERAS) protocol, including prokinetic medications, is commonly used to prevent postoperative ileus. Prospective studies evaluating the effectiveness of mosapride citrate, a prokinetic 5-hydroxytryptamine 4 receptor agonist, in patients undergoing gastrectomy within the ERAS framework are lacking. This double-blind randomized trial included patients who were scheduled for laparoscopic or robotic gastrectomy for gastric cancer. Participants were randomly assigned to either a control (placebo) or experimental (mosapride citrate) group, with drugs administered on postoperative days 1-5...
March 25, 2024: Scientific Reports
https://read.qxmd.com/read/38528050/first-line-camrelizumab-a-pd-1-inhibitor-plus-apatinib-an-vegfr-2-inhibitor-and-chemotherapy-for-advanced-gastric-cancer-space-a-phase-1-study
#37
JOURNAL ARTICLE
Xiaofeng Chen, Hao Xu, Xiaobing Chen, Tongpeng Xu, Yitong Tian, Deqiang Wang, Fen Guo, Kangxin Wang, Guangfu Jin, Xiao Li, Rong Wang, Fengyuan Li, Yongbin Ding, Jie Tang, Yueyu Fang, Jing Zhao, Liang Liu, Ling Ma, Lijuan Meng, Zhiguo Hou, Rongrong Zheng, Yang Liu, Ni Guan, Bei Zhang, Shuang Tong, Shiqing Chen, Xing Li, Yongqian Shu
Patients with advanced gastric cancer typically face a grim prognosis. This phase 1a (dose escalation) and phase 1b (dose expansion) study investigated safety and efficacy of first-line camrelizumab plus apatinib and chemotherapy for advanced gastric or gastroesophageal junction adenocarcinoma. The primary endpoints included maximum tolerated dose (MTD) in phase 1a and objective response rate (ORR) across phase 1a and 1b. Phase 1a tested three dose regimens of camrelizumab, apatinib, oxaliplatin, and S-1. Dose regimen 1: camrelizumab 200 mg on day 1, apatinib 250 mg every other day, oxaliplatin 100 mg/m² on day 1, and S-1 40 mg twice a day on days 1-14...
March 25, 2024: Signal Transduction and Targeted Therapy
https://read.qxmd.com/read/38527410/sers-based-ai-diagnosis-of-lung-and-gastric-cancer-via-exhaled-breath
#38
JOURNAL ARTICLE
Xin Xie, Wenrou Yu, Li Wang, Junjun Yang, Xiaobin Tu, Xiaochun Liu, Shihong Liu, Han Zhou, Runwei Chi, Yingzhou Huang
Distinct diagnosis between Lung cancer (LC) and gastric cancer (GC) according to the same biomarkers (e.g. aldehydes) in exhaled breath based on surface-enhanced Raman spectroscopy (SERS) remains a challenge in current studies. Here, an accurate diagnosis of LC and GC is demonstrated, using artificial intelligence technologies (AI) based on SERS spectrum of exhaled breath in plasmonic metal organic frameworks nanoparticle (PMN) film. In the PMN film with optimal structure parameters, 1780 SERS spectra are collected, in which 940 spectra come from healthy people (n = 49), another 440 come from LC patients (n = 22) and the rest 400 come from GC patients (n = 8)...
March 22, 2024: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://read.qxmd.com/read/38527388/prognostic-relevance-of-the-most-predominant-and-least-differentiated-grades-of-gastric-adenocarcinoma-after-curative-gastrectomy
#39
JOURNAL ARTICLE
Yasuo Imai, Yoshihiro Kurata, Masanori Ichinose
BACKGROUND: Prognostic relevance of differentiation grade has remained controversial in gastric adenocarcinoma (GAC) after curative resection. METHODS: GAC patients who underwent curative gastrectomy were analyzed. Differentiation grade was evaluated according to either the most predominant or least differentiated component. Impacts of clinicopathologic parameters on postoperative recurrence and nodal metastasis were analyzed by the multivariate Cox regression analysis in pT1/2/3/4a and pT1b/2/3 GAC and by the logistic regression analysis in pT1b GAC, respectively...
March 20, 2024: Surgical Oncology
https://read.qxmd.com/read/38526832/impact-of-18f-fdg-pet-ct-and-laparoscopy-in-staging-of-locally-advanced-gastric-cancer-a-cost-analysis-in-the-prospective-multicenter-plastic-study
#40
JOURNAL ARTICLE
Cas de Jongh, Miriam P van der Meulen, Emma C Gertsen, Hylke J F Brenkman, Johanna W van Sandick, Mark I van Berge Henegouwen, Suzanne S Gisbertz, Misha D P Luyer, Grard A P Nieuwenhuijzen, Jan J B van Lanschot, Sjoerd M Lagarde, Bas P L Wijnhoven, Wobbe O de Steur, Henk H Hartgrink, Jan H M B Stoot, Karel W E Hulsewe, Ernst Jan Spillenaar Bilgen, Marc J van Det, Ewout A Kouwenhoven, Freek Daams, Donald L van der Peet, Nicole C T van Grieken, Joos Heisterkamp, Boudewijn van Etten, Jan-Willem van den Berg, Jean-Pierre Pierie, Hasan H Eker, Annemieke Y Thijssen, Eric J T Belt, Peter van Duijvendijk, Eelco Wassenaar, Kevin P Wevers, Lieke Hol, Frank J Wessels, Nadia Haj Mohammad, Geert W J Frederix, Richard van Hillegersberg, Peter D Siersema, Erik Vegt, Jelle P Ruurda
BACKGROUND: Unnecessary D2-gastrectomy and associated costs can be prevented after detecting non-curable gastric cancer, but impact of staging on treatment costs is unclear. This study determined the cost impact of 18 F-fluorodeoxyglucose positron emission tomography/computed tomography (18F FDG-PET/CT) and staging laparoscopy (SL) in gastric cancer staging. MATERIALS AND METHODS: In this cost analysis, four staging strategies were modeled in a decision tree: (1) 18F FDG-PET/CT first, then SL, (2) SL only, (3) 18F FDG-PET/CT only, and (4) neither SL nor 18F FDG-PET/CT...
March 25, 2024: Annals of Surgical Oncology
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