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Clinical keratitis

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https://www.readbyqxmd.com/read/29781928/interface-fungal-keratitis-after-descemet-stripping-automated-endothelial-keratoplasty-a-review-of-the-literature-with-a-focus-on-outcomes
#1
Elizabeth McElnea, Billy Power, Conor Murphy
PURPOSE: To examine the management and associated outcomes of reported cases of interface fungal infection after Descemet stripping automated endothelial keratoplasty (EK). METHODS: A literature review identified reports of interface fungal infection after Descemet stripping automated EK. Data retrieved from the same included patient demographics, surgical procedure undertaken, donor rim culture result, clinical course, and outcome. A review of the relevant literature was also conducted...
May 16, 2018: Cornea
https://www.readbyqxmd.com/read/29781927/a-case-of-corneal-neovascularization-misdiagnosed-as-total-limbal-stem-cell-deficiency
#2
Qihua Le, C Michael Samson, Sophie X Deng
PURPOSE: To report a case of corneal neovascularization misdiagnosed as total limbal stem cell deficiency (LSCD). METHODS: This is a case report of a 61-year-old woman who has a history of bilateral idiopathic scleritis, keratitis, and uveitis for more than 20 years. She was diagnosed with total LSCD in her left eye based on clinical presentation alone and was confirmed as a candidate for limbal transplantation at several major tertiary eye care centers in the United States...
May 16, 2018: Cornea
https://www.readbyqxmd.com/read/29779647/in-vitro-susceptibility-and-multilocus-sequence-typing-of-fusarium-isolates-causing-keratitis
#3
P Dallé da Rosa, A Nunes, R Borges, B Batista, A Meneghello Fuentefria, L Z Goldani
Fungal keratitis is recognized as a significant cause of ocular morbidity and blindness especially in developing countries. In this study, we aimed to present the molecular identification and susceptibility of Fusarium isolates causing fungal keratitis in a university hospital in southern Brazil. The samples were identified using the second largest subunit of the RNA polymerase gene (RPB2) and the translation elongation factor 1-alpha (TEF1), while the antifungal susceptibility was tested by the broth microdilution method according to the Clinical and Laboratory Standards Institute (CLSI) methodology...
May 17, 2018: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/29758184/therapeutic-penetrating-keratoplasty-button-cultures-in-the-mycotic-ulcer-treatment-trial-ii-a-randomized-trial-comparing-oral-voriconazole-vs-placebo
#4
Julie Cho, N Venkatesh Prajna, Prajna Lalitha, Revathi Rajaraman, Tiruvengada Krishnan, Yijie Brittany Lin, Kathryn J Ray, Thomas M Lietman, Jennifer Rose-Nussbaumer
OBJECTIVE: To compare oral voriconazole versus placebo in addition to topical antifungals in the treatment of filamentous fungal keratitis. DESIGN: Non-prespecified, secondary case-control analysis from a multicenter, double-masked, randomized placebo-controlled clinical trial STUDY PARTICIPANTS: Patients with smear-positive filamentous fungal ulcers and visual acuity of 20/400 or worse who eventuated to therapeutic penetrating keratoplasty (TPK). INTERVENTION: Study participants were randomized to oral voriconazole versus oral placebo; all received topical antifungal drops...
May 11, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29757853/multiplex-polymerase-chain-reaction-assay-for-screening-of-mycotoxin-genes-from-ocular-isolates-of-fusarium-species
#5
Orapin Anutarapongpan, Jorge Maestre-Mesa, Eduardo C Alfonso, Terrence P OʼBrien, Darlene Miller
PURPOSE: To identify mycotoxin genes among clinical ocular isolates of Fusarium species and to correlate these with clinical outcomes of Fusarium keratitis. METHODS: Fifty-four clinical isolates of Fusarium were retrieved from the Bascom Palmer Eye Institute Ocular Microbiology Laboratory data bank. Multiplex polymerase chain reactions were run to confirm the identification of Fusarium species [internal transcribed spacer sequence, translation elongation factor 1-α (TEF) and β-tubulin] and to detect the presence of genes encoding production of fumonisin B mycotoxins (FUM1 and FUM8) and trichothecene mycotoxins (deoxynivalenol and nivalenol)...
May 1, 2018: Cornea
https://www.readbyqxmd.com/read/29749113/clinical-translation-of-recommendations-from-randomised-trials-for-management-of-herpes-simplex-virus-keratitis
#6
Maria Cabrera-Aguas, Dana Robaei, Peter McCluskey, Stephanie Watson
IMPORTANCE: Standardise initial anti-viral therapy for herpes simplex keratitis (HSK) BACKGROUND: To determine prescribing trends for the management of HSK and compare the trends to available clinical trial evidence. DESIGN: Retrospective review of patients at the Sydney Eye Hospital, Australia. PARTICIPANTS: Three hundred and one eyes of 296 patients prescribed anti-virals for HSK aged 18 years and above, from January 1, 2012 to December 31, 2013...
May 10, 2018: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/29730068/biofilm-testing-of-microbiota-an-essential-step-during-corneal-scrap-examination-in-egyptian-acanthamoebic-keratitis-cases
#7
Marwa A Hasby Saad, Haidy S M Khalil
PURPOSE: To detect co-infections in the culture-proven acanthamoebic keratitis (AK) cases, and to test the capability of biofilm formation in the isolated microbiota. The clinical findings, habit of wearing contact lens and in-vitro antibiotic resistance were analyzed further according to the biofilm formation capability. METHODS: After clinical examination, corneal scraps and swabs were taken from 240 clinically suspected AK cases, for Acanthamoeba and microbiological cultures...
May 3, 2018: Parasitology International
https://www.readbyqxmd.com/read/29724209/microbial-keratitis-induced-endophthalmitis-incidence-symptoms-therapy-visual-prognosis-and-outcomes
#8
Daniel Zapp, Daria Loos, Nikolaus Feucht, Ramin Khoramnia, Tamer Tandogan, Lukas Reznicek, Christian Mayer
BACKGROUND: To evaluate symptoms, therapies and outcomes in rare microbial keratitis-induced endophthalmitis. METHODS: Retrospective study with 11 patients treated between 2009 and 2014. Clinical findings, corneal diseases, history of steroids and trauma, use of contact lenses, number and type of surgical interventions, determination of causative organisms and visual acuity (VA) were evaluated. RESULTS: The incidence of transformation from microbial keratitis to an endophthalmitis was 0...
May 3, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29715322/clinical-analysis-of-fungal-keratitis-in-patients-with-and-without-diabetes
#9
Jing Dan, Qingjun Zhou, Hualei Zhai, Jun Cheng, Lei Wan, Cheng Ge, Lixin Xie
We compared the clinical characteristics, treatments, and prognoses of fungal keratitis in patients with and without diabetes. Patients diagnosed with fungal keratitis at Shandong Eye Institute between January 2010 and December 2016 were retrospectively reviewed and classified as diabetic and nondiabetic groups. One-hundred-and-eleven patients (111 eyes) with diabetes and 740 patients (740 eyes) without diabetes were included. The diabetic patients showed significantly older (p< 0.05) and lower male:female ratio (p<0...
2018: PloS One
https://www.readbyqxmd.com/read/29708932/adenoviral-keratitis-a-review-of-the-epidemiology-pathophysiology-clinical-features-diagnosis-and-management
#10
Amro A Omari, Shahzad I Mian
INTRODUCTION: Adenoviral keratitis is a common and bothersome ocular infection that produces a lot of burden on healthcare systems and patients. The goal of this article is to provide a review of the topic, with an emphasis on current attempts at advancing strategies in diagnosis and management. PATIENTS/MATERIALS AND METHODS: Sixty-eight articles and one textbook published on adenoviral keratitis were reviewed. The findings on the epidemiology, pathophysiology, clinical features, diagnosis, and management were summarized...
April 27, 2018: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/29708927/cytomegalovirus-keratitis
#11
Samuel C Faith, Asad F Durrani, Vishal Jhanji
PURPOSE OF REVIEW: Cytomegalovirus (CMV) keratitis, albeit an uncommon manifestation of this ubiquitous pathogen, can lead to devastating ocular morbidity. Timely diagnosis and appropriate treatment are also unfortunately uncommon. The purpose of this review is to discuss recently published literature regarding the epidemiology, pathophysiology, diagnosis, and therapy of CMV keratitis. RECENT FINDINGS: Classic clinical presentations of CMV keratitis are known; however, current investigations further elucidate characteristics of typical versus atypical disease...
April 27, 2018: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/29698816/common-staining-techniques-for-highlighting-acanthamoeba-cysts
#12
Y Le Govic, A Gonçalves, L de Gentile, M Pihet
As illustrated by our clinical case, microscopic examination of cultures using common stains as cotton blue or Kop-Color® may improve the efficiency of conventional laboratory diagnosis for Acanthamoeba keratitis.
April 23, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29695396/-burkholderia-cepacia-a-rare-cause-of-bacterial-keratitis
#13
Mohtar Ibrahim, Jin Yi Yap
We describe the first clinical case of Burkholderia cepacia keratitis registered in Southeast Asia. A man in his mid-70s with underlying poorly controlled diabetes mellitus came with complaints of painful red left eye for 4 days. This was accompanied with photophobia and blurring of vision after being injured by a wooden particle while cutting grass. Slit-lamp examination showed a paracentral anterior corneal stromal infiltrates with overlying epithelial defect. Culture of the corneal smear isolated B. cepacia that was sensitive to ceftazidime, meropenem and bactrim (trimethorprim and sulfomethoxazole)...
April 25, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29694651/antiglaucomatous-treatments-and-ocular-surface
#14
Houda Lajmi, Wady Ben Jalel, Wassim Hmaied, Amin Zahaf, Besma Ben Achour, Lamia El Fekih
BACKGROUND: the antiglaucomatous treatments interact with the ocular surface and can induce its alteration which may affect the therapeutic results Aim : to describe the interactions between the ocular surface and anti-glaucoma medications and to propose practical attitudes to prevent and manage this issue. METHODS: a retrospective study about 100 patients with a primary opened angle glaucoma treated with anti-glaucomatous drops containing preservatives. We performed an exhaustive examination of the ocular surface with fluorescein instillation to search superficial punctuate keratitis and to evaluate the break up time...
July 2017: La Tunisie Médicale
https://www.readbyqxmd.com/read/29687947/comparison-of-3-corneal-cytology-collection-methods-for-evaluating-equine-ulcerative-keratitis-cytobrush-kimura-platinum-spatula-and-handle-edge-of-scalpel-blade
#15
Laura Proietto, Sarah S Beatty, Caryn E Plummer
PURPOSE: To compare corneal cytology samples from three common sampling techniques: cytobrush (CB), Kimura platinum spatula (KS), and the handle edge of a scalpel blade (SB). METHODS: Equine patients presenting to the University of Florida College of Veterinary Medicine with ulcerative keratitis were included. Following diagnosis of corneal ulcer and sampling for microbial culture, two cytology samples per technique were collected with sterile CB, KS, and SB in a randomized order...
April 24, 2018: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/29681463/-fungal-keratitis-a-5-year-monocentric-retrospective-study-on-reunion-island
#16
G Hoarau, M Albrieux, T Martin-Phipps, K Zitte-Zehler, L Borry, J Peytral, D Garcia-Hermoso, S Picot
OBJECTIVES: Fungal keratitis is rare in France, but could be a severe sight-threatening condition. Here, we aimed to describe the epidemiology of fungal keratitis in Réunion Island. METHODS: In a retrospective study, we analyzed 13 culture-proven keratitis episodes, occurred between January 2013 and July 2017 in the ophthalmology ward of a University Hospital, Saint-Pierre. Twelve isolates were genotyped and antifungal susceptibility testing was performed. RESULTS: Corneal abrasion caused by vegetable matter was the main predisposing factor...
April 19, 2018: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29675368/mincle-in-the-innate-immune-response-of-mice-fungal-keratitis
#17
Guo-Rong Yu, Jing Lin, Jie Zhang, Cheng-Ye Che, Xu-Dong Peng, Cui Li, Li-Ting Hu, Guo-Qiang Zhu, Kun He, Gui-Qiu Zhao
AIM: To investigate how macrophage inducible C-type lectin (Mincle) influences inflammation in mice fungal keratitis induced by Aspergillus fumigatus ( A. fumigatus ). METHODS: C57BL/6 mice were infected with A. fumigatus after pretreated with Mincle agonist TDB or Mincle neutralizing antibody (MincleAb), taking DMSO or IgG as control group respectively. The cornea lesions were monitored with slit-lamp microscope and evaluated by clinical score. Mincle expression was assessed using reverse transcription-ploymerase chain reaction (RT-PCR) and immunostaining...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29670328/treatment-outcomes-in-the-dry-eye-amniotic-membrane-dream-study
#18
Marguerite B McDonald, Hosam Sheha, Sean Tighe, Susan B Janik, Frank W Bowden, Amit R Chokshi, Michael A Singer, Seema Nanda, Mujtaba A Qazi, Damon Dierker, Adam T Shupe, Brittany J McMurren
Purpose: To evaluate the efficacy of cryopreserved amniotic membrane (CAM) in reducing signs and symptoms of dry eye disease (DED) in a large patient population. Methods: A retrospective chart review at 10 clinical sites was done of patients with refractory DED who received CAM and completed at least 3 months of follow-up. Data collected were demographics; medical history including previous and current ocular treatment, diagnosis, clinical presentations, comorbidity, duration and frequency of treatment with CAM; and concomitant medications...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29657982/epithelial-ingrowth-following-laser-in-situ-keratomileusis-lasik-prevalence-risk-factors-management-and-visual-outcomes
#19
REVIEW
Darren Shu Jeng Ting, Sathish Srinivasan, Jean-Pierre Danjoux
The number of laser in situ keratomileusis (LASIK) procedures is continuing to rise. Since its first application for correcting simple refractive errors over 25 years ago, the role of LASIK has extended to treat other conditions, including postkeratoplasty astigmatism/ametropia, postcataract surgery refractive error and presbyopia, among others. The long-term effectiveness, predictability and safety have been well established by many large studies. However, due to the creation of a potential interface between the flap and the underlying stroma, interface complications such as infectious keratitis, diffuse lamellar keratitis and epithelial ingrowth may occur...
2018: BMJ open ophthalmology
https://www.readbyqxmd.com/read/29657977/expert-practice-patterns-and-opinions-on-corneal-cross-linking-for-infectious-keratitis
#20
Yen C Hsia, Caitlin A Moe, Thomas M Lietman, Jeremy D Keenan, Jennifer Rose-Nussbaumer
Objective: To assess the current opinion and practice patterns from cornea experts regarding the benefit of corneal cross-linking (CXL) for infectious keratitis (IK). Methods and analysis: An international survey was distributed to corneal specialists via an internet survey. The survey data collected were analysed with descriptive statistics. Results: A survey was sent to 190 recipients, and 29 (15%) respondents completed the survey with an average of 7 years' experience using CXL...
2018: BMJ open ophthalmology
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