Elisa Vicente Ribelato, Jéssica Wouk, Gabriela Gomes Celestino, Bianca Cerqueira Dias Rodrigues, Maria Laura Goussain Darido, Mario Gabriel Lopes Barboza, Tatiana Jabor Botura, Maylla Cardoso de Oliveira, Fábio Goulart de Andrade, Audrey A S G Lonni, João Carlos Palazzo de Mello, Sérgio Paulo Dejato da Rocha, Lígia C Faccin-Galhardi
Herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) infect, respectively, 67% and 13% of the world population, most commonly causing mild symptoms, such as blisters/ulcers. However, severe conditions such as keratitis, encephalitis, and systemic infections may occur, generally associated with the patient's immunological condition. Although Acyclovir® (ACV) and its analogs are the reference drugs for herpetic infections, the number of ACV-resistant HSV infections is growing exponentially. Therefore, new natural products' bioactive compounds have been studied to develop novel effective anti-herpetics...
June 20, 2023: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]