Weichen Liu, Xue Tian, Lingwen Gu, Bing Yu, Ziyi Wang, Menghui Chi, Jing Lin, Qian Wang, Guibo Liu, Guiqiu Zhao, Cui Li
Fungal keratitis (FK) is a refractory keratitis caused by excessive inflammation and fungal damage. Excessive inflammation can lead to tissue damage and corneal opacity, resulting in a poor prognosis for FK. Oxymatrine (OMT) is a natural alkaloid, which has rich pharmacological effects, such as antioxidant and anti-inflammation. However, its antifungal activity and the mechanism of action in FK have not been elucidated. This study confirmed that OMT suppressed Aspergillus fumigatus growth, biofilm formation, the integrity of fungal cell and conidial adherence...
February 14, 2024: Experimental Eye Research