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Fungal keratitis

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https://www.readbyqxmd.com/read/28087293/first-itraconazole-resistant-aspergillus-fumigatus-clinical-isolate-harbouring-a-g54e-substitution-in-cyp51ap-in-south-america
#1
Florencia Leonardelli, Laura Theill, María Elena Nardin, Daiana Macedo, Catiana Dudiuk, Emilce Mendez, Soledad Gamarra, Guillermo Garcia-Effron
BACKGROUND: A 27-year-old male rural worker was admitted with a fungal keratitis due to an injury involving plant detritus. MATERIALS AND METHODS: Specimens were collected for microscopy examination and culture. The isolate was identified by morphological and molecular criteria. Susceptibility testing was performed using CLSI methods. CYP51A gene was PCR amplified and sequenced. RESULTS: An Aspergillus fumigatus strain resistant to itraconazole (MIC>8μg/ml) was isolated...
January 10, 2017: Revista Iberoamericana de Micología
https://www.readbyqxmd.com/read/28081296/short-synthetic-%C3%AE-helical-forming-peptide-amphiphiles-for-fungal-keratitis-treatment-in-vivo
#2
Hong Wu, Shaoqiong Liu, Nikken Wiradharma, Zhan Yuin Ong, Yan Li, Yi Yan Yang, Jackie Y Ying
The emergence of fungal keratitis is on the rise globally. However, current antifungal therapeutics are ineffective in severe keratomycosis. Previously reported α-helical peptides comprising 8-14 amino acids demonstrate broad-spectrum antimicrobial activity both in vitro and in vivo. Here, α-helical peptides of the optimized sequences are investigated for antifungal biofilm in vitro and in vivo using a fungal biofilm-caused mouse keratitis model. The peptides with the optimal composition demonstrate higher α-helical propensity and improve antifungal activity in dispersing Candida albicans biofilm in vitro...
January 12, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28043985/in-vivo-confocal-microscopy-appearance-of-fusarium-and-aspergillus-species-in-fungal-keratitis
#3
Jaya Devi Chidambaram, Namperumalsamy Venkatesh Prajna, Natasha Larke, David Macleod, Palepu Srikanthi, Shruti Lanjewar, Manisha Shah, Prajna Lalitha, Shanmugam Elakkiya, Matthew J Burton
BACKGROUND: Clinical outcomes in fungal keratitis vary between Fusarium and Aspergillus spp, therefore distinguishing between species using morphological features such as filament branching angles, sporulation along filaments (adventitious sporulation) or dichotomous branching may be useful. In this study, we assessed these three features within Heidelberg Retina Tomograph 3 in vivo confocal microscopy (IVCM) images from culture-positive Fusarium and Aspergillus spp keratitis participants...
January 2, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28040524/corneal-higher-order-aberrations-in-infectious-keratitis
#4
Eisuke Shimizu, Takefumi Yamaguchi, Yukari Yaguchi, Murat Dogru, Yoshiyuki Satake, Kazuo Tsubota, Jun Shimazaki
PURPOSE: To characterize the corneal higher-order aberrations (HOAs) in eyes with acanthoamoeba keratitis (AK), bacterial keratitis (BK), and fungal keratitis (FK). DESIGN: Retrospective consecutive case series. METHODS: This retrospective study includes 18 normal subjects and 63 eyes of 62 consecutive patients with corneal scarring due to AK (20 eyes), BK (35 eyes) and FK (8 eyes) from 2010 to 2016. HOAs of the anterior and posterior surfaces and the total cornea were analyzed by anterior segment optical coherence tomography (AS-OCT)...
December 28, 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28035615/epidemio-clinico-microbiological-study-of-mycotic-keratitis-in-north-west-region-of-rajasthan
#5
Abhishek Binnani, Priyanka Soni Gupta, Ankur Gupta
AIM AND OBJECTIVES: Mycotic keratitis, with its diverse clinical presentation and difficulties in treatment, makes it a challenging task for clinicians and an important object of study. The aim of present study was to determine the frequency of occurrence and epidemiological association with identification of fungal isolates from mycotic keratitis cases. MATERIALS AND METHODS: This was a prospective and observational study conducted in Mycology Laboratory, Department of Microbiology, S...
December 29, 2016: Mycopathologia
https://www.readbyqxmd.com/read/28025573/diagnosis-and-treatment-of-pythium-insidiosum-corneal-ulcer-in-a-chinese-child-a-case-report-and-literature-review
#6
Hong He, Hongshan Liu, Xiaolian Chen, Jiaochan Wu, Miao He, Xingwu Zhong
BACKGROUND Pythium insidiosum keratitis is a rare but sight-threatening disease with a high morbidity rate. It can be misdiagnosed as fungal keratitis in clinic settings. We report a case of severe Pythium insidiosum keratitis in a Chinese child, treated with combined approaches. CASE REPORT A 7-year-old boy from Hainan province in the south of China developed a suppurative corneal ulcer after being in a forest. A mass of hyphae was detected by confocal imaging in vivo, fungal smear test, and histochemical examination...
December 27, 2016: American Journal of Case Reports
https://www.readbyqxmd.com/read/28003991/the-pathogenic-spectrum-of-fungal-keratitis-in-northwestern-china
#7
Na An, Xian-Ning Liu, Ya-Ni Wang, Juan-Li Zhu, Hua Yang, Jie Wu, Xiao-Zhao Yang, Xiu-Ping Zhu
No abstract text is available yet for this article.
2016: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28002842/efficacy-of-antibody-to-pnag-against-keratitis-caused-by-fungal-pathogens
#8
Ge Zhao, Tanweer S Zaidi, Cagla Bozkurt-Guzel, Tauqeer H Zaidi, James A Lederer, Gregory P Priebe, Gerald B Pier
Purpose: Developing immunotherapies for fungal eye infections is a high priority. We analyzed fungal pathogens for expression of the surface polysaccharide, poly-N-acetyl glucosamine (PNAG), and used a mouse model of ocular keratitis caused by Aspergillus flavus, A. fumigatus, or Fusarium solani to determine if PNAG was an immunotherapy target and requirements for ancillary cellular and molecular immune effectors. Methods: Enzyme-linked immunosorbent assay (ELISA) or immunofluorescence was used to detect PNAG on fungal cells...
December 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28001007/fungal-keratitis-dealing-with-a-diverse-kingdom-of-ocular-assailants
#9
EDITORIAL
Charles Nj McGhee, Bia Z Kim
No abstract text is available yet for this article.
December 2016: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/27998732/pathogenesis-of-microbial-keratitis
#10
REVIEW
Sahreena Lakhundi, Ruqaiyyah Siddiqui, Naveed Ahmed Khan
Microbial keratitis is a sight-threatening ocular infection caused by bacteria, fungi, and protist pathogens. Epithelial defects and injuries are key predisposing factors making the eye susceptible to corneal pathogens. Among bacterial pathogens, the most common agents responsible for keratitis include Staphylococcus aureus, Pseudomonas aeruginosa, Streptococcus pneumonia and Serratia species. Fungal agents of corneal infections include both filamentous as well as yeast, including Fusarium, Aspergillus, Phaeohyphomycetes, Curvularia, Paecilomyces, Scedosporium and Candida species, while in protists, Acanthamoeba spp...
December 17, 2016: Microbial Pathogenesis
https://www.readbyqxmd.com/read/27994804/microbial-profile-of-corneal-ulcers-in-a-tertiary-care-hospital-in-south-india
#11
Chittur Y Ranjini, Vishnu V Waddepally
PURPOSE: To identify the prevalence and microbial profile of infectious keratitis in a tertiary eye care hospital, and to test for the in vitro antimicrobial resistance of the bacterial isolates. METHODS: A total of 312 patients presenting to a tertiary eye care hospital with infected corneal ulcer were enrolled in this study. Their socio-demographic data and risk factors were recorded. Corneal scrapings collected from the edge of the ulcer were processed for direct gram stain and KOH mount...
October 2016: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/27994401/streptococcus-agalactiae-endophthalmitis-in-boston-keratoprosthesis-in-a-patient-with-steven-johnson-syndrome
#12
Humoud M Al-Otaibi, Mohammed Talea, Omar Kirat, Donald U Stone, William N May, Igor Kozak
A 25-year-old Syrian male with a previous episode of Stevens-Johnson syndrome with bilateral corneal cicatrization previously underwent surgery for Type 1 Boston Keratoprosthesis (K-Pro). Sixteen months after the K-Pro surgery, the patient presented with decreased vision to hand motion and microbial keratitis of the graft around the K-Pro with purulent discharge. Corneal scrapings were nonrevealing. B-scan in 3 days showed increased debris in the vitreous cavity and thickened retinochoroidal layer. Intravitreal tap and injections of vancomycin and ceftazidime were performed...
October 2016: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/27990375/review-of-clinical-and-basic-approaches-of-fungal-keratitis
#13
REVIEW
Jie Wu, Wen-Song Zhang, Jing Zhao, Hong-Yan Zhou
Fungal keratitis (FK) is a serious disease which can cause blindness. This review has current information about the pathogenesis, limitations of traditional diagnosis and therapeutic strategies, immune recognition and the diagnosis and therapy of FK. The information of this summary was reviewed regularly and updated as what we need in the diagnosis and therapy of FK nowadays.
2016: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/27990355/corneal-collagen-cross-linking-and-liposomal-amphotericin-b-combination-therapy-for-fungal-keratitis-in-rabbits
#14
Zhao-Qin Hao, Jin-Xin Song, Shi-Yin Pan, Lin Zhang, Yan Cheng, Xian-Ning Liu, Jie Wu, Xiang-Hua Xiao, Wei Gao, Hai-Feng Zhu
AIM: To observe the therapeutic effect of corneal collagen cross-linking (CXL) in combination with liposomal amphotericin B in fungal corneal ulcers. METHODS: New Zealand rabbits were induced fungal corneal ulcers by scratching and randomly divided into 3 groups, i.e. control, treated with CXL, and combined therapy of CXL with 0.25% liposomal amphotericin B (n=5 each). The corneal lesions were documented with slit-lamp and confocal microscopy on 3, 7, 14, 21 and 28d after treatment...
2016: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/27989423/-diagnostic-and-therapeutic-contribution-of-microbiological-analysis-in-severe-microbial-keratitis-at-reims-university-hospital-between-2012%C3%A2-and-2014
#15
J Caliot, D Guindolet, A Ducasse, L Andreoletti, C Arndt
PURPOSE: To investigate the contribution of microbial analysis in the diagnosis and management of severe microbial keratitis. MATERIAL AND METHOD: This is a monocentric retrospective study at the University Hospital of Reims from January 2012 to December 2014. Corneal scrapings with infectious keratitis were subjected to routine bacterial and fungal culture. PCR was also performed to detect various viral DNA (VZV, CMV, EBV, HSV 1 & 2, adenovirus) and Acanthamoeba sp...
December 15, 2016: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/27987408/label-free-electrical-sensing-of-bacteria-in-eye-wash-samples-a-step-towards-point-of-care-detection-of-pathogens-in-patients-with-infectious-keratitis
#16
Hardik J Pandya, Manoj Kumar Kanakasabapathy, Saloni Verma, Manjyot Kaur Chug, Adnan Memic, Mihaela Gadjeva, Hadi Shafiee
The diagnosis of keratitis is based on visual exam, tissue cytology, and standard microbial culturing to determine the type of the infectious pathogen. To prescribe appropriate therapy, it is important to distinguish between bacterial, fungal, and viral keratitis, as the treatments are quite different. Diagnosis of the causative organism has a substantial prognostic importance. Further, timely knowledge of the nature of the pathogen is also critical to adapt therapy in patients unresponsive to empiric treatment options, which occurs in 10% of all cases...
December 13, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27960579/genus-distribution-of-bacteria-and-fungi-associated-with-keratitis-in-a-large-eye-center-located-in-southern-china
#17
Lixia Lin, Weizhong Lan, Bingsheng Lou, Hongmin Ke, Yuanzhe Yang, Xiaofeng Lin, Lingyi Liang
PURPOSE: To investigate the genus distribution of bacteria and fungi associated with keratitis in a large eye center located in Southern China and to compare the results with existing data from other areas in China. METHODS: All results of corneal microbiological examinations from 2009 to 2013 of patients who had been clinically diagnosed with bacterial or fungal keratitis were obtained chronologically and anonymously from the microbiology database at Zhongshan Ophthalmic Center...
December 14, 2016: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/27930797/unusual-severe-interface-inflammation-after-uneventful-small-incision-lenticule-extraction-smile
#18
Damien Guindolet, Abdellatif Badaoui, Maud Elluard, Sophie Stephan, Serge Doan, Isabelle Cochereau, Eric E Gabison
PURPOSE: To describe a 40-year-old woman who complained of visual loss in her left eye 3 days after an uneventful bilateral myopic refractive surgery by small incision lenticule extraction (SMILE). METHODS: Case report. RESULTS: A 4 × 5 mm anterior central stromal infiltration was observed with moderate pain associated with decreased corneal sensitivity and neither discharge nor fluorescein staining. Bacterial and fungal smears and cultures from the SMILE interface were negative and local antibiotic ineffective...
December 1, 2016: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/27910191/tintelnotia-a-new-genus-in-phaeosphaeriaceae-harbouring-agents-of-cornea-and-nail-infections-in-humans
#19
S A Ahmed, W Hofmüller, M Seibold, G S de Hoog, H Harak, I Tammer, A D van Diepeningen, W Behrens-Baumann
Phaeosphaeriaceae is a family in the order Pleosporales containing numerous plant pathogens, endophytes, lichenised fungi, and environmental saprobes. A novel genus, Tintelnotia is introduced containing two species, one of which caused an eye infection and several nail infections in humans. All species of Tintelnotia produce conidia in soft pycnidia with a wide ostiole. The generic type species is T. opuntiae causing necrotic spots on cactus plants. The isolates of the human opportunist T. destructans showed variable susceptibility pattern to a panel of common antifungal agents...
December 1, 2016: Mycoses
https://www.readbyqxmd.com/read/27898982/evaluation-of-corneal-cross-linking-for-treatment-of-fungal-keratitis-using-confocal-laser-scanning-microscopy-on-an-ex-vivo-human-corneal-model
#20
Jawaher M Alshehri, David Caballero-Lima, M Chantal Hillarby, Susan G Shawcross, Arun Brahma, Fiona Carley, Nick D Read, Hema Radhakrishnan
Purpose: Some previous reports have established the use of photoactivated chromophore-induced corneal cross-linking (PACK-CXL) in treating fungal keratitis. The results of these case reports have often been conflicting. To systematically study the effect of PACK-CXL in the management of Fusarium keratitis, we have developed an ex vivo model of human corneal infection using eye-banked human corneas. Methods: Sixteen healthy ex vivo human corneas were divided into four study groups: (1) untreated control, (2) cross-linked, (3) infected with fungal spores, and (4) infected with fungal spores and then cross-linked...
November 1, 2016: Investigative Ophthalmology & Visual Science
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