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Fungal keratitis

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https://www.readbyqxmd.com/read/29340642/identifying-corneal-infections-in-formalin-fixed-specimens-using-next-generation-sequencing
#1
Zhigang Li, Florian P Breitwieser, Jennifer Lu, Albert S Jun, Laura Asnaghi, Steven L Salzberg, Charles G Eberhart
Purpose: We test the ability of next-generation sequencing, combined with computational analysis, to identify a range of organisms causing infectious keratitis. Methods: This retrospective study evaluated 16 cases of infectious keratitis and four control corneas in formalin-fixed tissues from the pathology laboratory. Infectious cases also were analyzed in the microbiology laboratory using culture, polymerase chain reaction, and direct staining. Classified sequence reads were analyzed with two different metagenomics classification engines, Kraken and Centrifuge, and visualized using the Pavian software tool...
January 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29326852/unusual-course-of-crystalline-keratopathy-in-a-patient-with-graft-versus-host-disease
#2
Başak Bostancı, Yonca Aydın Akova
We present a case of infectious crystalline keratopathy in a patient with Graft-versus-Host disease (GVHD) who developed satellite fungal keratitis. A 51-year-old man was referred for bilateral total persistent corneal epithelial defects with severe dry eye. Although persistent epithelial defect healed with medical therapy, he developed stromal keratitis with satellite lesions confirmed to be secondary to Candida albicans. After three months of antifungal treatment and debridement, improvement of the infiltrates was obtained...
December 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/29319595/pythium-keratitis-leading-to-fatal-cavernous-sinus-thrombophlebitis
#3
Anubha Rathi, Arunaloke Chakrabarti, Tushar Agarwal, Neelam Pushker, Mukesh Patil, Hemant Kamble, Jeewan S Titiyal, Rishi Mohan, Seema Kashyap, Sanjay Sharma, Seema Sen, Gita Satpathy, Namrata Sharma
PURPOSE: To report a case of Pythium insidiosum keratitis leading to fatal cavernous sinus thrombophlebitis. METHODS: Case report. RESULTS: A 70-year-old man presented with excruciating pain, redness, and diminution of vision in his left eye for 2 weeks after washing his hair with tap water. A total corneal ulcer with surrounding infiltrates and associated corneal thinning was present. Corneal scraping revealed the presence of Gram-positive cocci...
January 9, 2018: Cornea
https://www.readbyqxmd.com/read/29305870/ophthalmic-econazole-hydrogels-for-the-treatment-of-fungal-keratitis
#4
Victoria Díaz-Tomé, Andrea Luaces-Rodríguez, Jesús Silva-Rodríguez, Sara Blanco-Dorado, Laura García-Quintanilla, José Llovo Taboada, José Blanco-Méndez, Michel Herranz, María Gil-Martínez, María Jesús Lamas, Miguel González-Barcia, Francisco J Otero-Espinar, Anxo Fernández-Ferreiro
Econazole is a feasible alternative treatment in the management of fungal keratitis. Nevertheless, its low water solubility is considered the main limitation to the incorporation into ophthalmic formulations. In this work, econazole nitrate is solubilized by using cyclodextrins to achieve an optimum therapeutic concentration. Phase solubility diagrams suggest a-cyclodextrin as the most effective cyclodextrin and later the inclusion complex formed with this one was characterised in solution by 1D, 2D-NMR and molecular modelling...
January 3, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29303885/candida-endophthalmitis-after-descemet-stripping-automated-endothelial-keratoplasty-with-grafts-from-both-eyes-of-a-donor-with-possible-systemic-candidiasis
#5
Sotiria Palioura, Kavitha Sivaraman, Madhura Joag, Adam Sise, Juan F Batlle, Darlene Miller, Edgar M Espana, Guillermo Amescua, Sonia H Yoo, Anat Galor, Carol L Karp
PURPOSE: To report 2 cases with late postoperative Candida albicans interface keratitis and endophthalmitis after Descemet stripping automated endothelial keratoplasty (DSAEK) with corneal grafts originating from a single donor with a history of presumed pulmonary candidiasis. METHODS: Two patients underwent uncomplicated DSAEK by 2 corneal surgeons at different surgery centers but with tissue from the same donor and were referred to the Bascom Palmer Eye Institute with multifocal infiltrates at the graft-host cornea interface 6 to 8 weeks later, and anterior chamber cultures that were positive for the same genetic strain of C...
January 4, 2018: Cornea
https://www.readbyqxmd.com/read/29285615/application-of-image-recognition-based-automatic-hyphae-detection-in-fungal-keratitis
#6
Xuelian Wu, Yuan Tao, Qingchen Qiu, Xinyi Wu
The purpose of this study is to evaluate the accuracy of two methods in diagnosis of fungal keratitis, whereby one method is automatic hyphae detection based on images recognition and the other method is corneal smear. We evaluate the sensitivity and specificity of the method in diagnosis of fungal keratitis, which is automatic hyphae detection based on image recognition. We analyze the consistency of clinical symptoms and the density of hyphae, and perform quantification using the method of automatic hyphae detection based on image recognition...
December 28, 2017: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/29273865/-tintelnotia-destructans-new-enemy-at-the-gates
#7
K J Habbe, A Frings, S Schrader, M Roth, C MacKenzie, G Walther, O Kurzai, G Geerling
Tintelnotia destructans is a fungal species described for the first time in 2016, which can cause infections of the nails and of the cornea. We describe the second known case worldwide of Tintelnotia destructans-associated keratitis and its therapy. A good sensitivity for amphotericin B and voriconazole was demonstrated in the resistogram for the first time and the successful clinical course was confirmed. The present case study also shows the importance of intensive diagnostics in atypical microbial keratitis...
December 22, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/29233457/antimicrobial-efficacy-of-a-novel-povidone-iodine-contact-lens-disinfection-system
#8
Katsuhide Yamasaki, Fumio Saito, Ritsue Ota, Simon Kilvington
PURPOSE: Contact lens (CL) wear is a risk factor for the acquisition of microbial keratitis. Accordingly, compliance to manufacturers' recommended hygiene and disinfection procedures are vital to safe (CL) use. In this study we evaluated a novel povidone-iodine (PI) (CL) disinfection system (cleadew, Ophtecs Corporation, Japan) against a range of bacterial, fungal and Acanthamoeba. METHODS: Antimicrobial assays were conducted according to ISO 14729 using the recommended strains of bacteria and fungi, with and without the presence of organic soil...
December 7, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/29228372/a-novel-tomographic-imaging-probe-for-rapid-diagnosis-of-fungal-keratitis
#9
Min Hee Lee, Gregory Wiedman, Steven Park, Arkady Mustaev, Yanan Zhao, David S Perlin
Fungal keratitis is a leading cause of ocular morbidity and blindness in developing countries. Diagnosing fungal keratitis currently relies on a comparative evaluation of corneal biopsy or scraping using a direct microscopy and culture results. These methods not only carry the risk of developing complications due to the invasive tissue sampling but also are largely limited by diagnostic speed and accuracy, making it difficult to initiate timely appropriate antifungal therapy. Therefore, rapid and noninvasive diagnostic tools are a pressing need for improved outcomes for fungal keratitis...
December 8, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29219900/diagnostic-challenges-in-nocardia-keratitis
#10
Joséphine Behaegel, Sorcha Ní Dhubhghaill, Carina Koppen
OBJECTIVE: To present a case of diagnostic confusion in Nocardia keratitis in a contact lens wearer and to illustrate the characteristic clinical findings of this rare entity. METHODS: Case report of Nocardia keratitis that was mistaken for acanthamoeba, herpetic, and fungal keratitis in three tertiary corneal referral centers before the correct diagnosis of Nocardia infection was made. RESULTS: A 29-year-old contact lens wearer was referred to our hospital for a contact lens-associated bacterial keratitis, not improving under standard bacterial treatment...
December 5, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/29210317/enhanced-ocular-bioavailability-of-fluconazole-from-niosomal-gels-and-microemulsions-formulation-optimization-and-in-vitro-in-vivo-evaluation
#11
Osama Abd El-Aazeem Soliman, Elham Abdel Monem Mohamed, Nabil Abdullah Ali Khatera
Fungal keratitis may cause vision loss if it is not treated. Methods other than ocular delivery exhibited several limitations. No previous studies investigated and compared ocular bioavailability of fluconazole (FLZ) from niosomal gels and microemulsions. Niosomal gels of FLZ (0.3% w/w) based on Span® 60 and cholesterol (CH) using 1% w/w carbopol® 934 (CP) were evaluated. FLZ microemulsions (0.3% w/v) containing isopropyl myristate (IPM, as oil phase) and a 3:1 mixture of Tween® 80 (as surfactant) and polyethylene glycol 400 (PEG 400, as cosurfactant) were characterized...
December 6, 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/29193858/exophiala-phaeomuriformis-keratitis-in-a-subarctic-climate-region-a-case-report
#12
André Vicente, Fátima Pedrosa Domellöf, Berit Byström
PURPOSE: To report a case of Exophiala phaeomuriformis mycotic keratitis in a patient from a subarctic climate region. Dematiaceous fungi (black yeasts) have been gaining importance as corneal keratitis and ulcer causative agents in certain regions, but no cases have been described in Scandinavia. METHODS: Case report of a patient with a persistent corneal erosion that eventually presented a brown-pigmented infiltrate. The patient had a history of several months of topical therapy comprising medication for glaucoma, corticosteroids and antibiotics...
November 29, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29192684/early-deep-anterior-lamellar-keratoplasty-for-fungal-keratitis-poorly-responsive-to-medical-treatment
#13
F Sabatino, E Sarnicola, C Sarnicola, G M Tosi, P Perri, V Sarnicola
PurposeTo investigate the efficacy of early therapeutic deep anterior lamellar keratoplasty (DALK) in eradicating fungal keratitis that is poorly responsive to medical treatment.Patients and methodsTwenty-three eyes (23 patients) underwent early therapeutic DALK within 15 to 50 days from the onset of symptoms. The adopted eligibility criteria for early DALK included the following: active fungal keratitis affecting the optical zone with ulcer confined in the 6.00 mm central cornea; deeper than 150 μm but not exceeding 300 μm; and poorly responsive to medical treatment...
December 1, 2017: Eye
https://www.readbyqxmd.com/read/29181230/fungal-keratitis-study-of-increasing-trend-and-common-determinants
#14
Yogesh Acharya, Bhawana Acharya, Priyanka Karki
Fungal keratitis is one of the leading cause of ocular morbidity. Fungal keratitis possesses a clinical challenge due to its slow pathologic process, overlapping features, diagnostic difficulty, and potential complications. Its increasing trend can be attributed to the use of contact lens, non-judiciary corticosteroid, and vegetative trauma. Early diagnosis and treatment is the cornerstone for its effective control. Knowledge of pathological course and clinical characteristics of fungal keratitis will definitely add in early diagnosis and treatment, with reduction in ocular morbidity...
June 2017: Nepal journal of epidemiology
https://www.readbyqxmd.com/read/29176453/role-of-confocal-microscopy-in-the-diagnosis-of-pythium-insidiosum-keratitis
#15
Orapin Anutarapongpan, Onsiri Thanathanee, Jittraporn Worrawitchawong, Olan Suwan-Apichon
PURPOSE: To investigate the role of in vivo confocal microscopy for detection of Pythium insidiosum keratitis. METHODS: Medical records and confocal microscopy findings of 20 patients (21 eyes) with culture- or polymerase chain reaction-proven P. insidiosum keratitis diagnosed at the Khon Kaen University Eye Center from January 2009 to December 2015 were retrospectively reviewed. Confocal microscopy was performed using Nidek ConfoScan 4. The images from 21 eyes with P...
November 22, 2017: Cornea
https://www.readbyqxmd.com/read/29162991/magnusiomyces-capitatus-a-new-and-emerging-pathogen-linked-to-keratomycosis
#16
Ankit Shah, Thomas Mauger
We describe our experience managing a case of fungal keratitis in a 71-year-old immunocompetent woman. Intracameral cultures isolated Magnusiomyces capitatus, a dimorphic commensal microbe with limited pathogenicity, in an immune competent patient. Repeated corneal cultures for bacteria and fungus were negative. Initial broad-spectrum topical fortified antibiotics were eventually escalated to include topical natamycin and voriconazole and oral voriconazole. The patient underwent emergent corneal transplantation, but recurrent infection eventually required anterior chamber washout and intracameral injection of amphotericin B...
2017: Digital Journal of Ophthalmology: DJO
https://www.readbyqxmd.com/read/29155590/semisynthesis-and-biological-evaluation-of-xanthone-amphiphilics-as-selective-highly-potent-antifungal-agents-to-combat-fungal-resistance
#17
Shuimu Lin, Wan Ling Wendy Sin, Jun-Jie Koh, Fanghui Lim, Lin Wang, Derong Cao, Roger W Beuerman, Li Ren, Shouping Liu
New efficient antifungal agents are urgently needed to treat drug-resistant fungal infections. Here, we designed and synthesized a series of cationic xanthone amphiphilics as antifungal agents from natural α-mangostin to combat fungal resistance. The attachment of cationic residues on the xanthone scaffold of α-mangostin resulted in interesting antifungal agents with a novel mode of action. Two lead compounds (1 and 2) showed potent antifungal activity against a wide range of fungal pathogens, including drug-resistant C...
November 20, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29150218/keratitis-secondary-to-fusarium-spp-in-spain-2012-2014
#18
M A Mosquera Gordillo, N Barón Cano, A Garralda Luquin, C López Gutiérrez, E Mengual Verdú, G Trujillo Cabrera, J M Garrido Fierro, J Lamarca Mateu, J C Sánchez España, P Marticorena Álvarez, R Feijoó Lera, S Martín Nalda, T Marti Huguet, V Gacía Conca
OBJECTIVE: To describe the clinical-epidemiological characteristics of a case series of fungal keratitis associated with Fusarium spp.., in Spain during the years 2012 to 2014. METHODS: A retrospective study of a case series was conducted on a systematic random sample of 10% of patients identified in Health Centres of provincial capitals (n=250). The centres were asked whether they had been presented with cases of Fusarium spp. keratitis characterised by microbiological methods...
November 14, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/29150029/-fungal-keratitis
#19
REVIEW
T Bourcier, A Sauer, A Dory, J Denis, M Sabou
Fungal keratitis, or keratomycoses, are corneal infections which must be considered in cases of corneal trauma, prior corneal surgery, chronic ocular surface disease, topical corticosteroids or contact lens wear. Filamentous fungi or yeasts may be involved. Presenting clinical features such as corneal infiltrates with feathery edges and/or raised surface, intact epithelium with deep stromal involvement, satellite lesions, endothelial plaques, lack of improvement with antibiotics and worsening with steroids are suggestive of fungal keratitis...
November 14, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29135707/outcome-of-therapeutic-keratoplasty-in-hopeless-microbial-keratitis-cases-otherwise-advised-evisceration
#20
Rajat Jain, Karma L Bhutia, Neha Mohan, Col K C Gupta, Ashwani Ghai
PURPOSE: To study the outcome of therapeutic keratoplasty in severe microbial keratitis cases otherwise advised evisceration. METHODS: A retrospective, single-center clinical audit included 28 patients with severe microbial keratitis presenting from April 2014 to April 2016. Patients with microbial keratitis either affecting more than 2 quadrants of the limbus and/or cases with infections involving more than 180 mm of the cornea who were advised evisceration by more than one ophthalmologist were included...
February 2018: Cornea
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