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Fungal keratitis

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https://www.readbyqxmd.com/read/28810564/clinical-efficacy-of-conjunctival-flap-surgery-in-the-treatment-of-refractory-fungal-keratitis
#1
Honorine Nizeyimana, Dan-Dan Zhou, Xiu-Fen Liu, Xiao-Tao Pan, Cong Liu, Cheng-Wei Lu, Ji-Long Hao
The aim of the present study was to investigate the use and effectiveness of a selective, partial, pedunculated (tongue-shaped) conjunctival flap (CF) for the treatment of refractory fungal keratitis (FK) with or without perforation. A total of 31 cases of corneal diseases treated by CF surgery between April 2014 and October 2015 were evaluated. Among the 31 cases, 16 cases (male:female, 11:5) with FK were selected. Logistic regression analysis was used to investigate factors associated with complications of CF surgery...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28775086/tailored-lamellar-keratoplasty-a-new-technique
#2
Mohammad Solaimani, Seyed Ali Tabatabaei, Zahra Fallah Tafti
We present a new method for treating complicated corneal gaps among patients who have previously undergone radial keratotomy (RK).After complete healing of a fungal keratitis in a patient who has undergone RK, we removed the oedematous corneal sector and put anterior tailored segment of a corneal button previously used for Descemet stripping endothelial keratoplasty. The patient's best-corrected visual acuity reached to 20/20 6 months later. This technique will compensate for oedematous parts without putting a significant effect on other parts such as purse string sutures...
August 3, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28770882/visual-outcome-in-patients-of-keratomycosis-at-a-tertiary-care-centre-in-larkana-pakistan
#3
Syed Imtiaz Ali Shah, Shujaat Ali Shah, Partab Rai, Naeem Akhtar Katpar, Safdar Ali Abbasi, Akbar Ali Soomro
OBJECTIVE: To study the post-treatment visual outcome of fungal keratitis. METHODS: This prospective study was carried out at Chandka Medical College and Hospital, Larkana, Pakistan, from March 2005 to March 2016. Patients with clinical features of fungal keratitis, with positive corneal scrapings for fungi, and those who followed up for a minimum period of three months after recovery from infection were included.Other causes of infectious keratitis were excluded...
July 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28761565/first-reported-case-of-donor-related-candida-endophthalmitis-after-descemet-membrane-endothelial-keratoplasty
#4
Matthew Thompson, David Carli
PURPOSE: To report the first case of Candida donor to host transmission following descemet membrane endothelial keratoplasty (DMEK). METHODS: A retrospective case report. RESULTS: A patient underwent uneventful DMEK. Following surgery the donor rim was culture positive for Candida. The patient developed fungal endophthalmitis that was treated medically with multiple injections of voriconazole and amphotericin. Medical treatment was unable to clear the infection and removal of the donor material was required...
2017: Open Ophthalmology Journal
https://www.readbyqxmd.com/read/28739646/koh-mount-as-an-aid-in-the-management-of-infectious-keratitis-at-secondary-eye-care-centre
#5
Varsha M Rathi, Monica Thakur, Savitri Sharma, Rohit Khanna, Prashant Garg
AIMS: To report the clinical outcome of infectious keratitis managed after doing 10% KOH mount of corneal smears and reporting done by an ophthalmologist in the secondary eye care centre in South India. METHODS: 103 consecutive cases of microbial keratitis were studied. Inclusion criteria were presence of corneal infiltrate on slit lamp biomicroscopy. An ophthalmologist carried out microbiological evaluation of 10% KOH mount of corneal scrapings. No cultures were done at secondary centres...
July 24, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28708218/microbial-characteristics-of-posttraumatic-infective-keratitis
#6
Blanche X Lim, Victor T C Koh, Manotosh Ray
PURPOSE: To determine the demographics, risk factors, clinical and microbiological characteristics, and treatment outcome of posttraumatic infective keratitis. METHODS: Consecutive patients with posttraumatic infective keratitis presenting to the Ophthalmology Department of a tertiary referral hospital in Singapore between March 2012 and March 2016 were prospectively identified. A standardized data collection form was used to document patient demographics, microbiological diagnosis, antibiotic sensitivity, and pretreatment and posttreatment ocular characteristics...
July 8, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28704321/observation-of-retrocorneal-plaques-in-patients-with-infectious-keratitis-using-anterior-segment-optical-coherence-tomography
#7
Yuki Takezawa, Takashi Suzuki, Atsushi Shiraishi
PURPOSE: Endothelial plaques are a typical characteristic in patients with fungal keratitis. However, bacterial keratitis and herpetic keratouveitis are rarely associated with fibrin formation on the retrocorneal surface. This study was conducted to examine plaques attached to the endothelium in patients with infectious keratitis using anterior segment optical coherence tomography (AS-OCT). METHODS: Seventeen patients (10 women and 7 men; mean age, 75 ± 15.5 years) suspected to have infectious keratitis with retrocorneal plaques were included...
July 11, 2017: Cornea
https://www.readbyqxmd.com/read/28702317/fungal-keratitis-caused-by-metarhizium-anisopliae-complex
#8
Mahmood J Showail, Julianne V Kus, George Kar Tsui, Hall F Chew
PURPOSE: To report a case of fungal keratitis caused by Metarhizium anisopliae complex. METHODS: Case report. RESULTS: Our patient presented with a central corneal infiltrate. Fungal culture yielded a Metarhizium species. She was started on antifungal agents with no significant improvement. A therapeutic corneal transplant was performed after perforation. At two years follow up, she was free of infection. CONCLUSION: Metarhizium anisopliae is a very rare cause of keratitis...
September 2017: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/28691942/rose-bengal-photodynamic-antimicrobial-therapy-a-novel-treatment-for-resistant-fusarium-keratitis
#9
Guillermo Amescua, Alejandro Arboleda, Neda Nikpoor, Heather Durkee, Nidhi Relhan, Mariela C Aguilar, Harry W Flynn, Darlene Miller, Jean-Marie Parel
PURPOSE: To evaluate the efficacy of rose bengal PDAT for the management of a patient with multidrug-resistant Fusarium keratoplasticum keratitis unresponsive to standard clinical treatment. METHODS: This case report presents a clinical case of F. keratoplasticum keratitis not responsive to standard medical care. In vitro studies from patients culture isolated responded to rose bengal PDAT. Patient received two treatments with rose bengal 0.1% and exposure to green light with a total energy of 2...
September 2017: Cornea
https://www.readbyqxmd.com/read/28681884/condition-responsive-nanoparticles-for-managing-infection-and-inflammation-in-keratitis
#10
Saad M Ahsan, Ch Mohan Rao
Keratitis is a major cause of avoidable visual impairment. About 30% of patients with fungal keratitis eventually become permanently blind in the developing world. Proteases, secreted by the pathogen and the host, damage the cornea before the infection is resolved. Treating keratitis is a challenge because both infection and inflammation need to be addressed. An additional challenge is to maintain a therapeutic dose at the corneal surface as blinking and tear film wash away the drugs, administered as eye drops...
July 20, 2017: Nanoscale
https://www.readbyqxmd.com/read/28658821/intracorneal-amphotericin-b-injection-in-a-case-of-indolent-candidal-keratitis
#11
Jyoti Deswal, Sudesh Kumar Arya
Ocular candidiasis is one of the opportunistic infection occurring in human body. Pathogenesis wise, Candida is very virulent and slow growing organism. We report a case of 76-year-old female with left eye candidal stromal abscess, not responding to topical and oral antifungal drugs. Patient was administered intrastromal amphotericin B injection in the affected eye. Four midstromal injections were given in the areas surrounding the corneal abscess. A total of approximately 0.05 mL of amphotericin B, 5 μg per 0...
May 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28632575/clinical-profile-etiology-and-outcome-of-infantile-ocular-trauma-a-developing-country-perspective
#12
Vedang D Shah, Madhu Uddaraju, Amitabh Singh, Rashmi Ranjan Das
OBJECTIVE: The aim of this article was to study the clinical profile, etiology, and outcome of infantile ocular trauma in a developing country setting. METHODS: A retrospective study on corneal trauma in infants (≤12 months old) was undertaken in a tertiary care hospital during a 2-year period. An analysis of clinical profile, etiology, microbiological profile, clinical course, and outcome was studied. RESULTS: Seventy-six infants were included...
June 20, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28631638/clinicomicrobiological-profile-of-endophthalmitis-a-10-year-experience-in-a-tertiary-care-center-in-north-india
#13
Gita Satpathy, Niranjan Nayak, Meenakshi Wadhwani, Pradeep Venkwatesh, Atul Kumar, Yograj Sharma, Vishnu Sreenivas
PURPOSE: To determine the clinicomicrobiological profile of infectious agents and their antibiotic susceptibility in different type of endophthalmitis. METHODS: A retrospective review of clinical and microbiological records from January 2001 to December 2010, was performed in 1110 patients diagnosed with different type of endophthalmitis (postoperative, posttraumatic, endogenous and post keratitis) to record the demographic details, clinical presentations; microbiological agents isolated with their antimicrobial sensitivity pattern...
April 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28611646/corneal-cross-linking-as-a-treatment-for-fungal-keratitis-associated-with-corneal-melting
#14
Vadim Igal, Yael Sara Pikkel Igal, Yoav Yechezkel Pikkel
We present the case of a young male that suffered from fungal corneal abscess and corneal melting. The patient was treated successfully by corneal cross-linking. Taking into account our experience from this case, we offer to consider corneal cross-linking as a therapeutic option in cases of fungal keratitis.
January 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28603237/-contact-lens-related-fusarium-keratitis-a-case-report
#15
Silvia Amadasi, Giovanni Federico Pelliccioli, Paolo Colombini, Annalisa Bonomini, Claudio Farina, Filomena Pietrantonio, Palmino Pedroni
We aim to highlight the key factors for a good outcome of fungal keratitis. We describe a case of contact lens-related Fusarium keratitis in a young girl. After identification of Fusarium spp under direct microscopic examination and in culture, a prolonged treatment with topic natamycin 5% was started and administered for five months with restitutio ad integrum of the eye. Prompt microbiological diagnosis and a specific and prolonged treatment are essential for correct management of Fusarium keratitis.
June 1, 2017: Le Infezioni in Medicina
https://www.readbyqxmd.com/read/28599020/isg15-in-host-defense-against-candida-albicans-infection-in-a-mouse-model-of-fungal-keratitis
#16
Chen Dong, Nan Gao, Bing X Ross, Fu-Shin X Yu
Purpose: ISG15, a di-ubiquitin-like protein, is critical for controlling certain viral and bacterial infections. We sought to determine if ISG15 plays a role in corneal innate immunity against Candida albicans (C. albicans) using a C57BL/6 (B6) mouse model of human fungal keratitis. Methods: Scarified corneas of adult B6 mice were pretreated with TLR5 ligand flagellin and then inoculated with C. albicans. The expression of ISG15 and other genes involved in ISG15 conjugation (ISGylation) was determined by real-time PCR...
June 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28582375/pythium-insidiosum-keratitis-histopathology-and-rapid-novel-diagnostic-staining-technique
#17
Ruchi Mittal, Shipra K Jena, Alisha Desai, Sunil Agarwal
PURPOSE: To elucidate the histopathology of Pythium insidiosum keratitis and to describe a novel, simple, and rapid staining technique for identification of oomycete Pythium insidiosum and to differentiate it from fungi. METHODS: This is a laboratory investigation study of 38 nonconsecutive cases (37 ocular samples and 1 colonic biopsy); 14 microbiologically diagnosed as Pythium insidiosum keratitis and 24 as fungal keratitis. Review of clinical, demographic details, microbiological results, and identification of cases that necessitated evisceration was performed...
June 2, 2017: Cornea
https://www.readbyqxmd.com/read/28573109/persistence-of-innate-immune-pathways-in-late-stage-human-bacterial-and-fungal-keratitis-results-from-a-comparative-transcriptome-analysis
#18
Jaya D Chidambaram, Shichina Kannambath, Palepu Srikanthi, Manisha Shah, Prajna Lalitha, Shanmugam Elakkiya, Julien Bauer, Namperumalsamy V Prajna, Martin J Holland, Matthew J Burton
Microbial keratitis (MK) is a major cause of blindness worldwide. Despite adequate antimicrobial treatment, tissue damage can ensue. We compared the human corneal transcriptional profile in late stage MK to normal corneal tissue to identify pathways involved in pathogenesis. Total RNA from MK tissue and normal cadaver corneas was used to determine transcriptome profiles with Illumina HumanHT-12 v4 beadchips. We performed differential expression and network analysis of genes in bacterial keratitis (BK) and fungal keratitis (FK) compared with control (C) samples...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28546688/collagen-cross-linking-for-microbial-keratitis
#19
REVIEW
Prashant Garg, Sujata Das, Aravind Roy
Collagen cross-linking is gaining popularity not only for arresting the progression of keratoconus but also other indications including management of corneal infections. In this review article, we analyzed the published literature to understand the level of evidence for its use in corneal ulcer. Photoactivated riboflavin and ultraviolet A light are known to possess antimicrobial properties. The treatment also induces formation of inter- and intra-fibrillar bonds, thereby making the corneal collagen resistant to the action of proteases arresting stromal melt...
January 2017: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/28524886/fungal-keratitis-in-the-republic-of-ireland
#20
S Farrell, E McElnea, S Moran, S Knowles, C C Murphy
PurposeFungal keratitis is relatively rare in temperate climates with only one previous population-based study, which reported a minimum annual incidence of 0.32 per million population in the United Kingdom. We performed a nationwide study in the Republic of Ireland of cases over a 6-year period to establish the incidence, risk factors, treatment, and outcomes of fungal keratitis.Patients and methodsAll corneal scraping specimens positive for fungal species over a 6-year period were identified at the microbiology departments of the seven main ophthalmology units in the Republic of Ireland...
May 19, 2017: Eye
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