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https://www.readbyqxmd.com/read/29903589/-corneal-collagen-cross-linking-to-treat-infectious-keratitis
#1
REVIEW
R Atia, L Jouve, J Knoeri, C Georgeon, L Laroche, V Borderie, N Bouheraoua
Infectious keratitis are a frequent cause of ocular morbidity. Today, new treatments are necessary to combat the emergence of antibiotic resistant germs. Corneal collagen cross-linking has been suggested to treat corneal infectious (PACK-CXL). Its action would be both antimicrobial and protective for the cornea, increasing its biochemical resistence to proteolytic enzymes. In vivo, PACK-CXL might demonstrate good efficacy against bacterial keratitis, contrary to herpetic keratitis for which it is contraindicated...
June 11, 2018: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29887864/triggering-receptors-expressed-on-myeloid-cells-2-promotes-corneal-resistance-against-pseudomonas-aeruginosa-by-inhibiting-caspase-1-dependent-pyroptosis
#2
Wenting Qu, Yi Wang, Yongjian Wu, Yiting Liu, Kang Chen, Xi Liu, Zhengyu Zou, Xi Huang, Minhao Wu
Triggering receptors expressed on myeloid cells 2 (TREM2) is a novel cell surface receptor and functions as an immunomodulatory receptor in infectious diseases. In this study, we investigated the function and regulatory mechanism of TREM2 in Pseudomonas aeruginosa ( P. aeruginosa ) keratitis. We found that P. aeruginosa keratitis was more severe in Trem2 -/- versus wild type C57BL/6 mice as indicated by the increased clinical scores, bacterial load, and cornea pathology. The exacerbated disease progression caused by TREM2 deficiency was associated with boosted activation of caspase-1 and subsequent pyroptosis as well as increased expression of IL-1β...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29881840/antibiotic-functionalised-polymers-reduce-bacterial-biofilm-and-bioburden-in-a-simulated-infection-of-the-cornea
#3
Natalya Doroshenko, Stephen Rimmer, Richard Hoskins, Prashant Garg, Thomas Swift, Hannah L M Spencer, Rianne M Lord, Maria Katsikogianni, David Pownall, Sheila MacNeil, C W Ian Douglas, Joanna Shepherd
Microbial keratitis can arise from penetrating injuries to the cornea. Corneal trauma promotes bacterial attachment and biofilm growth, which decrease the effectiveness of antimicrobials against microbial keratitis. Improved therapeutic efficacy can be achieved by reducing microbial burden prior to antimicrobial therapy. This paper assesses a highly-branched poly(N-isopropyl acrylamide) with vancomycin end groups (HB-PNIPAM-van), for reducing bacterial attachment and biofilm formation. The polymer lacked antimicrobial activity against Staphylococcus aureus, but significantly inhibited biofilm formation (p = 0...
June 8, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29846426/seasonal-distribution-of-ocular-conditions-treated-at-the-emergency-room-a-1-year-prospective-study
#4
Emine Sen, Selda Celik, Merve Inanc, Ufuk Elgin, Beyhan Ozyurt, Pelin Yılmazbas
PURPOSE: To determine the clinical characteristics and seasonal distribution of patients admitted to the ocular emergency department of a tertiary ophthalmology care center. METHODS: The study cohort includes 27,120 patients who were admitted to ocular emergency room between November 2013 and November 2014. The age, sex, reason for admission, diagnosis, and complete ocular examination reports were recorded for each patient. X-ray and ultrasonographic examinations were performed if necessary...
April 2018: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/29797413/evaluation-of-microbial-contamination-of-canine-plasma-eyedropper-bottles-following-clinical-use-in-canine-patients
#5
Rachel A Strauss, Ulrike Genschel, Rachel A Allbaugh, Lionel Sebbag, Gil Ben-Shlomo
OBJECTIVE: To investigate microbial contamination of canine plasma eye drops when used clinically and to compare the effect of two different eyedropper bottles on contamination rate. METHODS: Forty-six bottles containing plasma were randomly dispensed for use on 42 dogs with ulcerative keratitis. Of these, 23 were standard eyedropper bottles and 23 were Novelia® bottles designed to prevent contamination. After use for up to 2 weeks, samples for bacterial culture were obtained from a drop of plasma, the bottle tip, the plasma inside the bottle, and the corneal surface...
May 24, 2018: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/29730068/biofilm-testing-of-microbiota-an-essential-step-during-corneal-scrap-examination-in-egyptian-acanthamoebic-keratitis-cases
#6
Marwa A Hasby Saad, Haidy S M Khalil
PURPOSE: To detect co-infections in the culture-proven acanthamoebic keratitis (AK) cases, and to test the capability of biofilm formation in the isolated microbiota. The clinical findings, habit of wearing contact lens and in-vitro antibiotic resistance were analyzed further according to the biofilm formation capability. METHODS: After clinical examination, corneal scraps and swabs were taken from 240 clinically suspected AK cases, for Acanthamoeba and microbiological cultures...
May 3, 2018: Parasitology International
https://www.readbyqxmd.com/read/29695396/-burkholderia-cepacia-a-rare-cause-of-bacterial-keratitis
#7
Mohtar Ibrahim, Jin Yi Yap
We describe the first clinical case of Burkholderia cepacia keratitis registered in Southeast Asia. A man in his mid-70s with underlying poorly controlled diabetes mellitus came with complaints of painful red left eye for 4 days. This was accompanied with photophobia and blurring of vision after being injured by a wooden particle while cutting grass. Slit-lamp examination showed a paracentral anterior corneal stromal infiltrates with overlying epithelial defect. Culture of the corneal smear isolated B. cepacia that was sensitive to ceftazidime, meropenem and bactrim (trimethorprim and sulfomethoxazole)...
April 25, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29673332/expression-of-cytokines-in-aqueous-humor-from-fungal-keratitis-patients
#8
Yingnan Zhang, Qingfeng Liang, Yang Liu, Zhiqiang Pan, Christophe Baudouin, Antoine Labbé, Qingxian Lu
BACKGROUND: Although a series of reports on corneal fungal infection have been published, studies on pathogenic mechanisms and inflammation-associated cytokines remain limited. In this study, aqueous humor samples from fungal keratitis patients were collected to examine cytokine patterns and cellular profile for the pathogenesis of fungal keratitis. METHODS: The aqueous humor samples were collected from ten patients with advanced stage fungal keratitis. Eight aqueous humor samples from patients with keratoconus or corneal dystrophy were taken as control...
April 19, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29657977/expert-practice-patterns-and-opinions-on-corneal-cross-linking-for-infectious-keratitis
#9
Yen C Hsia, Caitlin A Moe, Thomas M Lietman, Jeremy D Keenan, Jennifer Rose-Nussbaumer
Objective: To assess the current opinion and practice patterns from cornea experts regarding the benefit of corneal cross-linking (CXL) for infectious keratitis (IK). Methods and analysis: An international survey was distributed to corneal specialists via an internet survey. The survey data collected were analysed with descriptive statistics. Results: A survey was sent to 190 recipients, and 29 (15%) respondents completed the survey with an average of 7 years' experience using CXL...
2018: BMJ open ophthalmology
https://www.readbyqxmd.com/read/29643799/optical-coherence-tomography-examination-of-the-anterior-segment-in-a-case-of-corneal-perforation-and-lens-trauma-by-chestnut-burr
#10
Takashi Ono, Yosai Mori, Ryohei Nejima, Takuya Iwasaki, Shiro Amano, Kazunori Miyata
Chestnut burrs, the thorny encapsulation of chestnut fruit, can sometimes cause corneal injuries and ulceration, with poor prognoses. We report a case of corneal perforation and damaged anterior lens capsule due to a chestnut burr, using anterior segment optical coherence tomography (AS-OCT). A 67-year-old woman with a chestnut burr injury in her right eye was referred to our hospital. Her right best-corrected visual acuity (BCVA) was 0.8. Slit-lamp examination and AS-OCT showed perforation involving the endothelial layer at the center of the cornea...
January 2018: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29589177/time-dependent-antimicrobial-effect-of-photodynamic-therapy-with-tons-504-on-pseudomonas-aeruginosa
#11
Kentaro Sueoka, Taiichiro Chikama, Miftahul Akhyar Latief, Ji-Ae Ko, Yoshiaki Kiuchi, Takemasa Sakaguchi, Akira Obana
Pseudomonas aeruginosa (P. aeruginosa) is a major cause of infectious keratitis, which itself is a major cause of blindness worldwide. We have now evaluated the time-dependent effectiveness of photodynamic antimicrobial chemotherapy (PACT) with the chlorin derivative TONS 504 and a light-emitting diode (LED) on P. aeruginosa in vitro. PACT with TONS 504 (10 mg/L) and irradiation (30 J/m2 ) by an LED device that delivers light centered on a wavelength of 660 nm was applied to 1 × 106 colony-forming units of P...
March 27, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29580152/epidemiology-risk-factors-and-clinical-outcomes-in-severe-microbial-keratitis-in-south-india
#12
Jaya Devi Chidambaram, Namperumalsamy Venkatesh Prajna, Palepu Srikanthi, Shruti Lanjewar, Manisha Shah, Shanmugam Elakkiya, Prajna Lalitha, Matthew J Burton
PURPOSE: Here, we report risk factors associated with outcome in severe bacterial keratitis (BK), fungal keratitis (FK), and Acanthamoeba keratitis (AK) in India. METHODS: Prospective observational cohort study conducted in Aravind Eye Hospital, India. Adults presenting with severe microbial keratitis (MK) were enrolled (size ≥3 mm) and followed to 21 days post-enrolment. Ulcer clinical features were recorded at presentation. Outcomes by final visit were classified as good (completely healed or reduced infiltrate size) or poor (enlarged infiltrate size, perforated, or surgery performed)...
March 26, 2018: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/29550185/in-vivo-confocal-microscopy-cellular-features-of-host-and-organism-in-bacterial-fungal-and-acanthamoeba-keratitis
#13
Jaya D Chidambaram, Namperumalsamy V Prajna, Srikanthi Palepu, Shruti Lanjewar, Manisha Shah, Shanmugam Elakkiya, David Macleod, Prajna Lalitha, Matthew J Burton
PURPOSE: To determine cellular features of fungal (FK), Acanthamoeba (AK), and bacterial keratitis (BK) using HRT3 in vivo confocal microscopy (IVCM). DESIGN: Prospective observational cross-sectional study. METHODS: Eligible participants were adults with microbiologically positive FK, AK, or BK, of size ≥ 3 mm, attending Aravind Eye Hospital from February 2012 to February 2013. Exclusion criteria were descemetocele or perforation. At presentation, IVCM imaging was performed, then corneal scrapes were obtained for culture/light microscopy...
June 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29490391/-microbial-keratitis-understand-recognize-and-treat-part-1-general-aspects-and-characteristics-of-bacterial-keratitis
#14
Ingo Schmack, Michael Müller, Thomas Kohnen
Infectious inflammation of the cornea (microbial keratitis) represents a potentially vision threatening disease. Depending on the infectious agent and the course of the disease it can result in a complete loss of the involved eye. Early diagnosis and accurate treatment are mandatory to maintain a sufficient visual acuity. The purpose of this review is to highlight and discuss characteristic clinical features, diagnostic procedures, and therapeutic aspects of three major forms of microbial keratitis (bacteria, fungi, and acanthamoeba; the latter two in the 2nd part of this article)...
March 2018: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29429293/-deep-anterior-lamellar-keratoplasty-combined-with-antiviral-therapy-in-the-treatment-of-severe-herpes-necrotizing-stromal-keratitis
#15
S X Li, J T Wang, Y Jiang, X Wang, W Y Shi
Objective: To evaluate the efficacy of modified deep lamellar keratoplasty (DLKP) combined with antiviral medications for severe herpes necrotizing stromal keratitis. Methods: Retrospective case series study. Modified DLKP was performed in combination with antiviral medications in fifty patients (50 eyes) with severe necrotizing stromal keratitis, which was unresponsive to systemic and topical antiviral treatment for 1 week, at Shandong Eye Hospital. Before surgery, the operated eyes were examined using slit-lamp microscopy...
February 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29390522/delayed-onset-mycobacterium-intracellulare-keratitis-after-laser-in-situ-keratomileusis-a-case-report-and-literature-review
#16
REVIEW
JaeSang Ko, Se Kyung Kim, Dong Eun Yong, Tae-Im Kim, Eung Kweon Kim
RATIONALE: Infectious keratitis is a relatively uncommon but potentially sight-threatening complication of laser in situ keratomileusis (LASIK). Mycobacterial keratitis is usually regarded as late onset keratitis among post-LASIK keratitis. There has been no documented case of Mycobacterium intracellulare post-LASIK keratitis of a long-latent period. PATIENT CONCERNS: A 36-year-old man was referred to our out-patient clinic, for persistent corneal epithelial defect with intrastromal infiltration...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29375989/a-comparative-study-of-risk-factors-for-corneal-infection-in-diabetic-and-non-diabetic-patients
#17
Bin Wang, Shuo Yang, Hua-Lei Zhai, Yang-Yang Zhang, Chun-Xia Cui, Jun-Yi Wang, Li-Xin Xie
AIM: To compare the clinical characteristics of infectious keratopathy in type 2 diabetes mellitus (T2DM) and non-diabetes mellitus (NDM) and to investigate risk factors for infectious keratopathy in T2DM patients. METHODS: Totally 230 patients with T2DM and 168 with NDM diagnosed as infectious keratopathy were hospitalized at Qingdao Eye Hospital from 2001 to 2015. Data including sex, age, occupation, season, smoking and alcohol consumption habits, duration between onset and treatments, duration of hospitalization were collected...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29369234/in-vitro-evaluation-of-a-hypochlorous-acid-hygiene-solution-on-established-biofilms
#18
Eric G Romanowski, Nicholas A Stella, Kathleen A Yates, Kimberly M Brothers, Regis P Kowalski, Robert M Q Shanks
OBJECTIVES: The purpose of this study was to determine whether a commercial formulation of hypochlorous acid hygiene solution (0.01%), Avenova, can destroy existing biofilms formed by ocular clinical bacterial isolates, including blepharitis isolates of Staphylococcus aureus and coagulase-negative staphylococci, and a keratitis isolate of Pseudomonas aeruginosa. METHODS: Biofilms grown in bacterial growth media on disposable contact lens cases were challenged with hypochlorous acid hygiene solution...
January 15, 2018: Eye & Contact Lens
https://www.readbyqxmd.com/read/29363971/design-and-syntheses-of-highly-potent-teixobactin-analogues-against-staphylococcus-aureus-methicillin-resistant-staphylococcus-aureus-mrsa-and-vancomycin-resistant-enterococci-vre-in-vitro-and-in-vivo
#19
Anish Parmar, Rajamani Lakshminarayanan, Abhishek Iyer, Venkatesh Mayandi, Eunice Tze Leng Goh, Daniel G Lloyd, Madhavi Latha S Chalasani, Navin K Verma, Stephen H Prior, Roger W Beuerman, Annemieke Madder, Edward J Taylor, Ishwar Singh
The cyclic depsipeptide, teixobactin, kills a number of Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), and Mycobacterium tuberculosis without detectable resistance. To date, teixobactin is the only molecule in its class that has shown in vivo antibacterial efficacy. In this work, we designed and synthesized 10 new in vivo ready teixobactin analogues. These analogues showed highly potent antibacterial activities against Staphylococcus aureus, MRSA, and vancomycin-resistant enterococci (VRE) in vitro...
March 8, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29350163/amebaborne-attilina-massiliensis-keratitis-france
#20
Alexandre Battaini, Bernard La Scola, Gaëlle Ho Wang Yin, Louis Hoffart, Michel Drancourt
We report a case of Acanthamoeba castellani keratitis in a person who wore contact lenses. The amebae hosted an ameba-resistant bacterial symbiont, provisionally named "Attilina massiliensis," a yet undescribed α-Proteobacterium.
February 2018: Emerging Infectious Diseases
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