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Ulcerative keratitis

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https://www.readbyqxmd.com/read/28201720/rapid-healing-of-peripheral-ulcerative-keratitis-in-rheumatoid-arthritis-with-prednisone-methotrexate-and-adalimumab-combination-therapy
#1
Peter Korsten, Dirk Bahlmann, Susann A Patschan
No abstract text is available yet for this article.
February 14, 2017: Rheumatology
https://www.readbyqxmd.com/read/28192845/-scleritis-progress-in-diagnosis-and-therapy
#2
D Pohlmann, U Pleyer
Inflammation of the sclera includes a wide range of morphological changes, which often occur in association with systemic diseases. While episcleritis is mainly harmless, scleritis often proceeds and is characterised by a destructive course. This may lead to important complications, that present as ulcerative keratitis, uveitis or secondary increases in intraocular pressure. As this form of inflammation is severe and there are often underlying diseases, this contribution focusses on differential diagnosis and current therapeutic approaches...
February 13, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28147401/necrotising-scleritis-and-peripheral-ulcerative-keratitis-associated-with-rheumatoid-arthritis-treated-with-rituximab
#3
S Hardy, K Hashemi, M Catanese, M Candil, P Zufferey, E Gabison, Y Guex-Crosier
Background Rheumatoid arthritis is a chronic and common inflammatory autoimmune disease. This primarily involves the synovia of the joints, but can cause many extra-articular manifestations as well, including peripheral ulcerative keratitis (PUK) and necrotising scleritis. These are often a threat to vision; they significantly compromise not only the eye's structural integrity but are also important for prognosis and need urgent management. History and signs Three cases of peripheral ulcerative keratitis associated with rheumatoid arthritis were recorded in the electronic databank of the Jules Gonin Uveitis Clinic, two with necrotising scleritis and peripheral ulcerative keratitis and one with only peripheral ulcerative keratitis...
February 1, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28138334/atopic-keratoconjunctivitis-complicated-by-kocuria-koreensis-keratitis-the-first-case
#4
Noriko Inada, Jun Shoji, Satoru Yamagami
BACKGROUND: Patients with atopic dermatitis have a predisposition to Staphylococcus aureus and a Herpes simplex virus infection. The treatment of atopic diseases with steroid and immunosuppressive agents induces opportunistic infection. However, there is a concern regarding visual prognosis in patients with atopic keratoconjunctivitis (AKC) complicated with infectious keratitis. We report an unusual case of an atopic shield ulcer with Kocuria keratitis. CASE PRESENTATION: A 51-year-old Japanese man presented with a 14-day history of eye pain and visual loss in his left eye...
2017: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/28123915/microsporidial-stromal-keratitis-successful-treatment-with-topical-voriconazole-and-oral-itraconazole
#5
Mircea Coca, James Kim, Sudhir Shenoy, Patricia Chévez-Barrios, Manuj Kapur
We report a case of microsporidial stromal keratitis successfully treated with topical voriconazole and oral itraconazole. A 30-year-old Hispanic male construction worker who wears contacts lenses presented with left eye erythematous, epiphora, and mild pain increasing over few days after failing previous antibiotics treatment. His best corrected visual acuity in the left eye was count fingers at three feet, and the slit lamp examination showed 3+ conjunctival injection, a circular central corneal ulcer 3...
December 20, 2016: Curēus
https://www.readbyqxmd.com/read/28109687/-ocular-graft-versus-host-disease-an-often-misdiagnosed-etiology-of-dry-eye-syndrome
#6
L Moyal, R Adam, J Akesbi, F T Rodallec, J-P Nordmann
PURPOSE: To report a case of severe ocular graft-versus-host disease (GVHD) after cataract surgery. METHODS: Observational case report. RESULTS: We describe the case of a 59-year-old man with postoperative corneal ulcer on his only functional eye. His past history reported allogenic bone marrow transplant. His visual acuity (VA) was limited to hand motions. Slit lamp examination revealed diffuse conjunctival hyperemia, severe blepharitis, Meibomian dysfunction, total corneal opacification with epithelial and stromal keratitis and neovascular invasion...
January 18, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28043985/in-vivo-confocal-microscopy-appearance-of-fusarium-and-aspergillus-species-in-fungal-keratitis
#7
Jaya Devi Chidambaram, Namperumalsamy Venkatesh Prajna, Natasha Larke, David Macleod, Palepu Srikanthi, Shruti Lanjewar, Manisha Shah, Prajna Lalitha, Shanmugam Elakkiya, Matthew J Burton
BACKGROUND: Clinical outcomes in fungal keratitis vary between Fusarium and Aspergillus spp, therefore distinguishing between species using morphological features such as filament branching angles, sporulation along filaments (adventitious sporulation) or dichotomous branching may be useful. In this study, we assessed these three features within Heidelberg Retina Tomograph 3 in vivo confocal microscopy (IVCM) images from culture-positive Fusarium and Aspergillus spp keratitis participants...
January 2, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28025573/diagnosis-and-treatment-of-pythium-insidiosum-corneal-ulcer-in-a-chinese-child-a-case-report-and-literature-review
#8
Hong He, Hongshan Liu, Xiaolian Chen, Jiaochan Wu, Miao He, Xingwu Zhong
BACKGROUND Pythium insidiosum keratitis is a rare but sight-threatening disease with a high morbidity rate. It can be misdiagnosed as fungal keratitis in clinic settings. We report a case of severe Pythium insidiosum keratitis in a Chinese child, treated with combined approaches. CASE REPORT A 7-year-old boy from Hainan province in the south of China developed a suppurative corneal ulcer after being in a forest. A mass of hyphae was detected by confocal imaging in vivo, fungal smear test, and histochemical examination...
December 27, 2016: American Journal of Case Reports
https://www.readbyqxmd.com/read/27995356/tripartite-motif-8-trim8-positively-regulates-pro-inflammatory-responses-in-pseudomonas-aeruginosa-induced-keratitis-through-promoting-k63-linked-polyubiquitination-of-tak1-protein
#9
Litao Guo, Weili Dong, Xiaoxiao Fu, Jing Lin, Zhijun Dong, Xiaobo Tan, Tiemin Zhang
Pseudomonas aeruginosa (PA)-induced keratitis is a rapidly progressive ocular infectious disease that often leads to inflammatory epithelial edema, stromal infiltration, tissue destruction, corneal ulceration, and vision loss. In this study, we investigate the role of tripartite motif 8 (TRIM8) in regulating the inflammatory process of PA-induced keratitis. The expression of TRIM8 was increased in mouse corneas and in vitro-cultured macrophages after PA infection. Knockdown of the expression of TRIM8 significantly inhibited the activation of NF-κB signaling and decreased the production of pro-inflammatory cytokines both in vivo and in vitro after infected with PA...
December 19, 2016: Inflammation
https://www.readbyqxmd.com/read/27994804/microbial-profile-of-corneal-ulcers-in-a-tertiary-care-hospital-in-south-india
#10
Chittur Y Ranjini, Vishnu V Waddepally
PURPOSE: To identify the prevalence and microbial profile of infectious keratitis in a tertiary eye care hospital, and to test for the in vitro antimicrobial resistance of the bacterial isolates. METHODS: A total of 312 patients presenting to a tertiary eye care hospital with infected corneal ulcer were enrolled in this study. Their socio-demographic data and risk factors were recorded. Corneal scrapings collected from the edge of the ulcer were processed for direct gram stain and KOH mount...
October 2016: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/27990355/corneal-collagen-cross-linking-and-liposomal-amphotericin-b-combination-therapy-for-fungal-keratitis-in-rabbits
#11
Zhao-Qin Hao, Jin-Xin Song, Shi-Yin Pan, Lin Zhang, Yan Cheng, Xian-Ning Liu, Jie Wu, Xiang-Hua Xiao, Wei Gao, Hai-Feng Zhu
AIM: To observe the therapeutic effect of corneal collagen cross-linking (CXL) in combination with liposomal amphotericin B in fungal corneal ulcers. METHODS: New Zealand rabbits were induced fungal corneal ulcers by scratching and randomly divided into 3 groups, i.e. control, treated with CXL, and combined therapy of CXL with 0.25% liposomal amphotericin B (n=5 each). The corneal lesions were documented with slit-lamp and confocal microscopy on 3, 7, 14, 21 and 28d after treatment...
2016: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/27989423/-diagnostic-and-therapeutic-contribution-of-microbiological-analysis-in-severe-microbial-keratitis-at-reims-university-hospital-between-2012%C3%A2-and-2014
#12
J Caliot, D Guindolet, A Ducasse, L Andreoletti, C Arndt
PURPOSE: To investigate the contribution of microbial analysis in the diagnosis and management of severe microbial keratitis. MATERIAL AND METHOD: This is a monocentric retrospective study at the University Hospital of Reims from January 2012 to December 2014. Corneal scrapings with infectious keratitis were subjected to routine bacterial and fungal culture. PCR was also performed to detect various viral DNA (VZV, CMV, EBV, HSV 1 & 2, adenovirus) and Acanthamoeba sp...
December 15, 2016: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/27987408/label-free-electrical-sensing-of-bacteria-in-eye-wash-samples-a-step-towards-point-of-care-detection-of-pathogens-in-patients-with-infectious-keratitis
#13
Hardik J Pandya, Manoj Kumar Kanakasabapathy, Saloni Verma, Manjyot Kaur Chug, Adnan Memic, Mihaela Gadjeva, Hadi Shafiee
The diagnosis of keratitis is based on visual exam, tissue cytology, and standard microbial culturing to determine the type of the infectious pathogen. To prescribe appropriate therapy, it is important to distinguish between bacterial, fungal, and viral keratitis, as the treatments are quite different. Diagnosis of the causative organism has a substantial prognostic importance. Further, timely knowledge of the nature of the pathogen is also critical to adapt therapy in patients unresponsive to empiric treatment options, which occurs in 10% of all cases...
December 13, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27977029/painful-acute-corneal-ulceration-and-anterior-stromal-keratitis-in-an-adolescent-with-reactive-arthritis
#14
Christopher J Lyons, Elham AlQahtani, Hughie Tsang, Gregory T Moloney, Jane Gardiner
Reactive arthritis is occasionally associated with conjunctivitis and uveitis, but rarely keratitis. The authors describe a patient with paracentral anterior stromal keratitis with overlying epithelial erosion and multiple satellite subepithelial infiltrates. The initial appearance and the severe pain were suggestive of an infectious process. Recovery was rapid following introduction of topical steroid, with features suggesting an immune process in the recovery phase. The authors suggest that a history of arthritis and/or recent enteritis should be sought in the work-up of an atypical keratitis with or without epithelial defect...
December 8, 2016: Journal of Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/27964790/the-eye-and-inflammatory-rheumatic-diseases-the-eye-and-rheumatoid-arthritis-ankylosing-spondylitis-psoriatic-arthritis
#15
REVIEW
Philip Ian Murray, Saaeha Rauz
Rheumatoid arthritis, ankylosing spondylitis and psoriatic arthritis are associated with potentially sight-threatening inflammatory eye disease. Although the ocular manifestations associated with ankylosing spondylitis and psoriatic arthritis are similar, such as anterior uveitis, this differs from rheumatoid arthritis where dry eye, peripheral ulcerative keratitis and scleritis are the major ocular complications. Apart from causing sight loss, these conditions are painful, debilitating, often recurrent or chronic and may require long-term therapy...
October 2016: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/27928519/antimicrobial-susceptibility-and-minimal-inhibitory-concentration-of-pseudomonas-aeruginosa-isolated-from-septic-ocular-surface-disease-in-different-animal-species
#16
L Leigue, F Montiani-Ferreira, B A Moore
The purpose of this study was to evaluate the antibiotic susceptibility profile of Pseudomonas aeruginosa isolated from different animal species with septic ocular surface disease. Sixteen strains of P. aeruginosa were isolated from different species of animals (dog, cat, horse, penguin and brown bear) with ocular surface diseases such as conjunctivitis, keratocojnuctivits sicca and ulcerative keratitis. These isolates were tested against 11 different antimicrobials agents using the Kirby-Bauer disk-diffusion method...
2016: Open veterinary journal
https://www.readbyqxmd.com/read/27923939/ocular-surface-squamous-neoplasia-masquerading-as-peripheral-ulcerative-keratitis
#17
Anita Ganger, Saranya Devi, Noopur Gupta, Murugesan Vanathi, Radhika Tandon
No abstract text is available yet for this article.
December 5, 2016: Tropical Doctor
https://www.readbyqxmd.com/read/27896784/ocular-involvement-associated-with-varicella-in-adults
#18
Salma Gargouri, Sana Khochtali, Sourour Zina, Molka Khairallah, Imen Zone-Abid, Imen Kaibi, Salim Ben Yahia, Jamel Feki, Moncef Khairallah
BACKGROUND: Varicella is a common infectious disease primarily of childhood that is usually benign and self-limited. It is, however, increasingly seen in adults who are at a higher risk of severe infection. Ocular complications of varicella are relatively uncommon and have been rarely described in adults. We describe herein five adults who developed ocular involvement in association with primary varicella-zoster virus infection. FINDINGS: Ocular manifestations included acute anterior uveitis in four eyes, with associated stromal keratitis in one of them, epithelial ulcerative keratitis in the two eyes of one patient, and acute retinal necrosis in one eye...
December 2016: Journal of Ophthalmic Inflammation and Infection
https://www.readbyqxmd.com/read/27894405/inhibition-of-matrix-metalloproteins-9-attenuated-candida-albicans-induced-inflammation-in-mouse-cornea
#19
C Dong, M G Yang
Since the severe corneal ulceration of mouse cornea is known to occur with inflammation. As one of imperative matrix metalloproteinase, the potential roles of matrix metalloproteins 9 (MMP9) in corneal ulceration and keratitis are still unveiled caused by fungal invasion. In this study, Candida albicans (CA) inoculated wild-type KM mice cornea was used as a model pathogen in corneal inflammation.  CA invasion significantly stimulated the expression of collagen IV and MMP9 detected by RT-PCR, Real-time PCR and Immunofluorescent staining in mouse cornea as soon as 6 hours post infection, and relatively decreased at 1 day post infection...
October 31, 2016: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/27861312/peripheral-ulcerative-keratitis-secondary-to-chronic-hepatitis-b-infection
#20
David W Wei, Christian Pagnoux, Clara C Chan
PURPOSE: To report a unique case of peripheral ulcerative keratitis secondary to hepatitis B virus (HBV)-associated cryoglobulinemia and vasculitis and its pharmacological and surgical treatment and 2-year follow-up. METHODS: A 52-year-old woman presented with unilateral eye pain and photophobia, arthralgia, remnants of a maculopapular rash, and subsequently facial numbness several weeks later. Her best spectacle-corrected visual acuity (BSCVA) in the affected eye was 20/80...
November 16, 2016: Cornea
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