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Ulcerative keratitis

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https://www.readbyqxmd.com/read/29341837/ocular-permeation-of-topical-tazocin-and-its-effectiveness-in-the-treatment-of-pseudomonas-aeruginosa-induced-keratitis-in-rabbits
#1
Sujaya Singh, Renu Agarwal, Zulhilmi Abdul Razak, Robin Ngu, Lwin L Nyein, Sushil Vasudevan, Marina Kapitonova, Azida Juana Kadir, Subrayan Visvaraja
PURPOSE: Pseudomonas aeruginosa is the most common causative organism for contact lens-associated corneal ulcer and is commonly treated with fluoroquinolones. With the emergence of resistant strains, it is important to investigate alternative therapies. Despite well-established efficacy of tazocin against systemic Pseudomonas infections, its topical use for the treatment of Pseudomonas keratitis has not been described, hence this study was aimed to find the ocular permeation of Tazocin and its efficacy in treating keratitis in rabbit eyes...
January 17, 2018: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29340650/colocalization-of-galectin-3-with-cd147-is-associated-with-increased-gelatinolytic-activity-in-ulcerating-human-corneas
#2
Andrea Cruzat, Miguel Gonzalez-Andrades, Jérôme Mauris, Dina B AbuSamra, Preethi Chidambaram, Kenneth R Kenyon, James Chodosh, Claes H Dohlman, Pablo Argüeso
Purpose: Galectin-3 is a carbohydrate-binding protein known to promote expression of matrix metalloproteinases, a hallmark of ulceration, through interaction with the extracellular matrix metalloproteinase inducer CD147. The aim of this study was to investigate the distribution of galectin-3 in corneas of patients with ulcerative keratitis and to determine its relationship to CD147 and the presence of gelatinolytic activity. Methods: This was an observational case series involving donor tissue from 13 patients with active corneal ulceration and 6 control corneas...
January 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29338721/infectious-keratoconjunctivitis-in-semi-domesticated-eurasian-tundra-reindeer-rangifer-tarandus-tarandus-microbiological-study-of-clinically-affected-and-unaffected-animals-with-special-reference-to-cervid-herpesvirus-2
#3
Javier Sánchez Romano, Torill Mørk, Sauli Laaksonen, Erik Ågren, Ingebjørg H Nymo, Marianne Sunde, Morten Tryland
BACKGROUND: Infectious keratoconjunctivitis (IKC) is one of the most common ocular diseases in ruminants worldwide. In addition to keratitis and conjunctivitis, animals with IKC can develop uveitis, corneal ulcer, and in severe cases, blindness. The bacteria Moraxella spp. has been described as the primary causative agent of infectious bovine keratoconjunctivitis (IBK) in cattle (Bos taurus), while Chlamydia spp. and Mycoplasma conjunctivae are considered the main causative agents of IKC in sheep (Ovis aries)...
January 16, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29321417/peripheral-ulcerative-keratitis-associated-with-granulomatosis-with-polyangiitis-emerging-despite-cyclophosphamide-successfully-treated-with-rituximab
#4
Yuya Fujita, Shoichi Fukui, Yushiro Endo, Sosuke Tsuji, Ayuko Takatani, Toshimasa Shimizu, Masataka Umeda, Ayako Nishino, Tomohiro Koga, Shin-Ya Kawashiri, Naoki Iwamoto, Kunihiro Ichinose, Mami Tamai, Hideki Nakamura, Tomoki Origuchi, Ryotaro Ueki, Masafumi Uematsu, Kaori Ishida, Kuniko Abe, Atsushi Kawakami
A 67-year-old Japanese man was diagnosed with granulomatosis with polyangiitis based on the presence of right maxillary sinusitis, proteinase 3 antineutrophil cytoplasmic antibody positivity, and right scleritis. A conjunctival biopsy specimen showed neutrophil-predominant infiltration around the vessels without granuloma. Because there was a risk of blindness, pulsed methylprednisolone and intravenous cyclophosphamide pulse therapy (IVCY) was started. However, it was ineffective, and peripheral ulcerative keratitis newly emerged...
January 11, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29319595/pythium-keratitis-leading-to-fatal-cavernous-sinus-thrombophlebitis
#5
Anubha Rathi, Arunaloke Chakrabarti, Tushar Agarwal, Neelam Pushker, Mukesh Patil, Hemant Kamble, Jeewan S Titiyal, Rishi Mohan, Seema Kashyap, Sanjay Sharma, Seema Sen, Gita Satpathy, Namrata Sharma
PURPOSE: To report a case of Pythium insidiosum keratitis leading to fatal cavernous sinus thrombophlebitis. METHODS: Case report. RESULTS: A 70-year-old man presented with excruciating pain, redness, and diminution of vision in his left eye for 2 weeks after washing his hair with tap water. A total corneal ulcer with surrounding infiltrates and associated corneal thinning was present. Corneal scraping revealed the presence of Gram-positive cocci...
January 9, 2018: Cornea
https://www.readbyqxmd.com/read/29318025/feline-dry-eye-syndrome-of-presumed-neurogenic-origin-a-case-report
#6
Lionel Sebbag, Patricia A Pesavento, Sebastian E Carrasco, Christopher M Reilly, David J Maggs
Case summary: A 14-year-old female spayed Abyssinian cat, which about 1 year previously underwent thoracic limb amputation, radiotherapy and chemotherapy for an incompletely excised vaccine-related fibrosarcoma, was presented for evaluation of corneal opacity in the left eye (OS). The ocular surface of both eyes (OU) had a lackluster appearance and there was a stromal corneal ulcer OS. Results of corneal aesthesiometry, Schirmer tear test-1 (STT-1) and tear film breakup time revealed corneal hypoesthesia, and quantitative and qualitative tear film deficiency OU...
January 2018: JFMS Open Reports
https://www.readbyqxmd.com/read/29308970/clinical-characteristics-of-17-patients-with-moraxella-keratitis
#7
Yui Tobimatsu, Noriko Inada, Jun Shoji, Satoru Yamagami
PURPOSE: To retrospectively investigate the clinical characteristics of Moraxella keratitis. PATIENTS AND METHODS: We reviewed the medical records of 17 patients with Moraxella keratitis. Onset age, sex, predisposing factors, initial clinical presentations, culture and antimicrobial susceptibility testing, and management and outcome of medical treatment were investigated. RESULT: Moraxella keratitis was more common in patients older than 40 years of age, and its representative initial presentation was a round-shaped ulcer with endothelial plaque (70...
January 8, 2018: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/29303889/factors-influencing-the-diagnostic-accuracy-of-laser-scanning-in-vivo-confocal-microscopy-for-acanthamoeba-keratitis
#8
Ahmad Kheirkhah, Vannarut Satitpitakul, Zeba A Syed, Rodrigo Müller, Sunali Goyal, Elmer Y Tu, Reza Dana
PURPOSE: To determine the factors that influence the sensitivity and specificity of laser-scanning in vivo confocal microscopy (IVCM) for diagnosing Acanthamoeba keratitis (AK). METHODS: This retrospective, controlled study included 28 eyes of 27 patients with AK and 34 eyes of 34 patients with bacterial keratitis (as the control group). All patients had undergone corneal imaging with a laser-scanning IVCM (Heidelberg Retina Tomograph 3 with the Rostock Cornea Module)...
January 4, 2018: Cornea
https://www.readbyqxmd.com/read/29300262/accelerated-corneal-cross-linking-with-photoactivated-chromophore-for-moderate-therapy-resistant-infectious-keratitis
#9
Boris Knyazer, Yonit Krakauer, Yael Baumfeld, Tova Lifshitz, Sabine Kling, Farhad Hafezi
PURPOSE: To evaluate the effect of accelerated corneal cross-linking with photoactivated chromophore (PACK-CXL) as additional treatment for therapy-resistant infectious keratitis. METHODS: In this interventional cohort study, 20 patients (11 men and 9 women), aged 65.5 (interquartile range = 21.5-78.5) years, who were hospitalized for moderate-sized therapy-resistant bacterial corneal ulcers (11/20 microbiologically confirmed) were treated with hypoosmolar 0.1% riboflavin solution and Ultraviolet A (UVA) irradiation for 3 minutes at 30 mW/cm (5...
January 3, 2018: Cornea
https://www.readbyqxmd.com/read/29273391/acanthamoeba-in-the-eye-can-the-parasite-hide-even-more-latest-developments-on-the-disease
#10
REVIEW
M M Juárez, L I Tártara, A G Cid, J P Real, J M Bermúdez, V B Rajal, S D Palma
Acanthamoeba spp. is a free living protozoan in the environment, but can cause serious diseases. Acanthamoeba keratitis (AK), a severe and painful eye infection, must be treated as soon as possible to prevent ulceration of the cornea, loss of visual acuity, and eventually blindness or enucleation. Although the disease affects principally contact lens (CLs) wearers, it is recognized nowadays as a cause of keratitis also in non-CLs wearers. Although the number of infections caused by these amoebae is low, AK is an emerging disease presenting an extended number of cases each year worldwide mostly due to the increasing use of CLs, but also to better diagnostic methods and awareness...
December 19, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/29260080/moraxella-atlantae-keratitis-presenting-with-an-infectious-ring-ulcer
#11
Alexander Barash, Timothy Y Chou
Purpose: Moraxella atlantae is a rare pathogen. Keratitis from this organism has never been specifically reported or described. In this report we provide the first clinical description and photograph of Moraxella atlantae infectious keratitis. Observations: A 41 year-old man presented with a three day history of left eye pain. He was found to have a corneal ring ulcer and infiltrate from which Moraxella atlantae was cultured. The patient was successfully treated with intensive topical gatifloxacin (0...
September 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29260079/a-stepping-stone-in-treating-dendritic-keratitis
#12
Hosam Sheha, Sean Tighe, Anny M S Cheng, Scheffer C G Tseng
Purpose: To report the outcome of self-retained amniotic membrane after debridement in recurrent dendritic keratitis. Observations: A 70-year-old female with a recurrent dendritic corneal ulcer received debridement followed by placement of self-retained amniotic membrane. Five days after treatment, the patient experienced a complete resolution of symptoms, marked reduction of inflammation, complete re-epithelialization of the cornea and improvement of visual acuity...
September 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29226254/empirical-treatment-of-bacterial-keratitis-an-international-survey-of-corneal-specialists
#13
Ariana Austin, Julie Schallhorn, Mike Geske, Mark Mannis, Tom Lietman, Jennifer Rose-Nussbaumer
Background/aims: New antibiotic agents and changing susceptibility patterns may have changed the empirical treatment of bacterial keratitis. Our objective in this study was to survey cornea specialists' practice patterns in the initial treatment of bacterial ulcers. Methods: This study consisted of a short online survey emailed to members of the Cornea Society listserv for an international sample of cornea specialists. Data collection began July 2014 and ended October 2014...
August 2017: BMJ open ophthalmology
https://www.readbyqxmd.com/read/29219900/diagnostic-challenges-in-nocardia-keratitis
#14
Joséphine Behaegel, Sorcha Ní Dhubhghaill, Carina Koppen
OBJECTIVE: To present a case of diagnostic confusion in Nocardia keratitis in a contact lens wearer and to illustrate the characteristic clinical findings of this rare entity. METHODS: Case report of Nocardia keratitis that was mistaken for acanthamoeba, herpetic, and fungal keratitis in three tertiary corneal referral centers before the correct diagnosis of Nocardia infection was made. RESULTS: A 29-year-old contact lens wearer was referred to our hospital for a contact lens-associated bacterial keratitis, not improving under standard bacterial treatment...
December 5, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/29212473/case-report-bilateral-mooren-ulcer-in-association-with-hepatitis-c
#15
Vesa Aaltonen, Mari Alavesa, Laura Pirilä, Eija Vesti, Mohammad Al-Juhaish
BACKGROUND: Mooren ulcer has been considered as an idiopathic autoimmune keratitis. However, it has been in some cases suggested to be associated with hepatitis C, although the evidence is very vague. CASE PRESENTATION: We present a case of a man who was diagnosed with a primary Mooren ulcer in his right eye. The eye became blind despite of intensive treatment with local medications and extensive surgical procedures. After 10 years, the patient was diagnosed with the same disease, now in his left, previously healthy eye...
December 6, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/29193858/exophiala-phaeomuriformis-keratitis-in-a-subarctic-climate-region-a-case-report
#16
André Vicente, Fátima Pedrosa Domellöf, Berit Byström
PURPOSE: To report a case of Exophiala phaeomuriformis mycotic keratitis in a patient from a subarctic climate region. Dematiaceous fungi (black yeasts) have been gaining importance as corneal keratitis and ulcer causative agents in certain regions, but no cases have been described in Scandinavia. METHODS: Case report of a patient with a persistent corneal erosion that eventually presented a brown-pigmented infiltrate. The patient had a history of several months of topical therapy comprising medication for glaucoma, corticosteroids and antibiotics...
November 29, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29192684/early-deep-anterior-lamellar-keratoplasty-for-fungal-keratitis-poorly-responsive-to-medical-treatment
#17
F Sabatino, E Sarnicola, C Sarnicola, G M Tosi, P Perri, V Sarnicola
PurposeTo investigate the efficacy of early therapeutic deep anterior lamellar keratoplasty (DALK) in eradicating fungal keratitis that is poorly responsive to medical treatment.Patients and methodsTwenty-three eyes (23 patients) underwent early therapeutic DALK within 15 to 50 days from the onset of symptoms. The adopted eligibility criteria for early DALK included the following: active fungal keratitis affecting the optical zone with ulcer confined in the 6.00 mm central cornea; deeper than 150 μm but not exceeding 300 μm; and poorly responsive to medical treatment...
December 1, 2017: Eye
https://www.readbyqxmd.com/read/29169733/use-of-copaifera-multijuga-for-acute-corneal-repair-after-chemical-injury-a-clinical-histopathological-and-toxicogenetic-study
#18
Fernanda Gosuen Gonçalves Dias, Adriana Torrecilhas Jorge, Lucas de Freitas Pereira, Ricardo Andrade Furtado, Sérgio Ricardo Ambrósio, Jairo Kenupp Bastos, Salvador Boccaletti Ramos, Fernando Chahud, Luis Gustavo Gosuen Gonçalves Dias, Cristiane Dos Santos Honsho, Denise Crispim Tavares
Copaiba oil is widely used in medicine, but there are no reports regarding its application in ophthalmology. Therefore, the objective of this study was to evaluate the clinical, histopathological and toxicogenetic effects of eye drops containing 0.1 and 0.5% of Copaifera multijuga Hayne oil on superficial corneal ulcers induced with alkali in the left eye of rats. For histological analysis, the percent reduction in ulcers and thickness of the corneal epithelium and stroma were evaluated 48 and 72 h after ulcer induction...
November 20, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29165410/-surgical-treatment-of-purulent-corneal-ulcers-in-eyes-with-neurotrophic-keratitis-and-paralytic-lagophthalmos
#19
Evg A Kasparova, O I Sobkova, E A Kasparova, A A Fedorov, A A Kasparov
AIM: to develop a surgical approach to the treatment of purulent corneal ulcer in eyes with neurotrophic keratitis with lagophthalmos after auditory neuroma removal or stroke. MATERIAL AND METHODS: A total of 12 patients (13 eyes) have been managed. All received combined surgery that included simultaneous keratoplasty, autoconjunctivoplasty, and permanent partial tarsorrhaphy. RESULTS: Ocular integrity was preserved in all cases, and also vision - in half of them...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/29129978/a-case-of-peripheral-ulcerative-keratitis-associated-with-autoimmune-hepatitis
#20
Hamoon Eshraghi, Aria Mahtabfar, Mohammad H Dastjerdi
Purpose: To describe a case of peripheral ulcerative keratitis in the setting of autoimmune hepatitis and possible overlap syndrome with primary sclerosing cholangitis. Case Report: A 48-year-old African American female with autoimmune hepatitis with possible overlap syndrome with primary sclerosing cholangitis presented with tearing, irritation, and injection of the left eye that was determined to be peripheral ulcerative keratitis. The patient was treated with topical and systemic steroids, immunosuppressant drugs (azathioprine and mycophenolate mofetil), a biologic (rituximab), and surgery (conjunctival resection), and the peripheral ulcerative keratitis epithelialized but ultimately led to corneal perforation...
2017: Case Reports in Medicine
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