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Infectious keratitis

Guigang Li, Jingmin Guo, Rong Liu, Weikun Hu, Lingjuan Xu, Juan Wang, Subo Cai, Hong Zhang, Yingting Zhu
Background: To explore the prevalence of lacrimal duct obstruction in patients with infectious keratitis, and the necessity of lacrimal duct dredge in the treatment of human infectious keratitis. Methodology/Principle Findings: The design is prospective, non-control case series. Thirty-one eyes from twenty-eight continuous patients with infectious keratitis were included in this study. The presence/absence of lacrimal duct obstruction was determined by the lacrimal duct irrigation test. The diagnosis of infectious keratitis was made based on clinical manifestations, cornea scraping microscopic examination and bacterial/fungus culture...
2016: International Journal of Medical Sciences
Myhanh Nguyen, Jay Siak, Soon-Phaik Chee, Vo Quang Hong Diem
PURPOSE: To describe the pattern of uveitis among Vietnamese at two eye hospitals in Southern Vietnam. METHODS: We retrospectively reviewed the charts of 212 consecutive uveitis cases that presented to two eye hospitals in Ho Chi Minh City, Vietnam, from July 2011 to February 2015. The patients were identified from a database maintained by the hospitals. Patients with keratitis, episcleritis, orbital inflammation, post-surgical endophthalmitis, traumatic iritis, and corneal graft rejection were excluded...
October 11, 2016: Ocular Immunology and Inflammation
Shreesha Kumar Kodavoor, Ramamurthy Dandapani, Ajay Ramesh Kaushik
A 32-year-old female patient underwent deep anterior lamellar keratoplasty (DALK) in both eyes for advanced keratoconus. She developed an infiltrate in the nasal paracentral interface of the left eye. In view of the paracentral location, localized epithelial removal/stromal scraping was done and the infiltrate was removed using forceps and sent for microbiological assay, which revealed fungal filaments. The patient successfully responded to intensive topical antifungal therapy with the maintenance of visual acuity...
August 2016: Indian Journal of Ophthalmology
Emmett T Cunningham, Nisha R Acharya, Esen K Akpek, Manfred Zierhut
No abstract text is available yet for this article.
October 2016: Ocular Immunology and Inflammation
Ricardo Alexandre Stock, Elcio Luiz Bonamigo, Emeline Cadore, Rafael Allan Oechsler
BACKGROUND: Infectious crystalline keratopathy is a rare, progressive infection characterized by the insidious progression of branches and crystalline corneal opacities with minimal or no inflammation. This case report describes the evolution of an infectious crystalline keratopathy caused by Cladosporium sp., which developed after tectonic keratoplasty in a patient with a history of ocular trauma. CASE PRESENTATION: A 40-year-old Brazilian male was the victim of firework-induced trauma to the left eye, which resulted in a corneal laceration that could not be sutured as well as a severe traumatic cataract...
2016: International Medical Case Reports Journal
Chia-Yi Lee, Yi-Ju Ho, Chi-Chin Sun, Hsin-Chiung Lin, Ching-Hsi Hsiao, David Hui-Kang Ma, Chi-Chun Lai, Hung-Chi Chen
Aspergillus species produces a wide spectrum of fungal diseases like endophthalmitis and fungal keratitis ophthalmologically, but there has been no report about blepharitis caused by Aspergilus flavus to date. Herein, we report a 61-year-old ethnic Han Taiwanese male who had suffered from pain with burning and foreign body sensation after an insect bite on his left eye. Specimens from bilateral eyelids suggested infection of A. flavus, whereas corneal scraping showed the presence of Gram-negative bacteria. He was admitted for treatment of infectious keratitis with topical antibiotic and antifungal eye drops...
September 12, 2016: American Journal of Tropical Medicine and Hygiene
Takefumi Yamaguchi, Pedram Hamrah, Jun Shimazaki
This review summarizes the recent literature regarding corneal imaging in human subjects using in vivo confocal microscopy. It also covers the recent literature on corneal immune cells, nerves, and tear cytokine levels in ocular surface diseases as well as corneal immune privilege. The significance of interactions between corneal immune cells and nerves in health, neurotrophic keratopathy, and infectious keratitis is discussed. Furthermore, bilateral alterations of immune cells and nerves in clinically unilateral corneal diseases and the link to changes of tear cytokines or neuropeptide levels in contralateral eyes are described...
November 2016: Cornea
Tamara L Lenis, Stephan Y Chiu, Simon K Law, Fei Yu, Anthony J Aldave
PURPOSE: To evaluate the safety of concurrent Boston type I keratoprosthesis (KPro) and glaucoma drainage device (GDD) implantation. DESIGN: Retrospective comparative study of a consecutive cohort of patients. SUBJECTS: Patients who underwent KPro implantation by a single surgeon (A.J.A.) with or without 1 concurrent Ahmed GDD (New World Medical, Inc., Rancho Cucamonga, CA) implantation between January 1, 2005, and January 31, 2015, were included...
September 7, 2016: Ophthalmology
I-Huang Lin, Yi-Sheng Chang, Sung-Huei Tseng, Yi-Hsun Huang
Infectious keratitis after penetrating keratoplasty (PK) is a devastating condition that may result in graft failure and poor visual outcome. In this study, we retrospectively reviewed the medical records of patients who underwent PK between 2009 and 2014, and recorded those who developed infectious keratitis. We compared the predisposing factors and organisms isolated to those identified in our previous study, conducted between 1989 and 1994. The incidence of post-PK infectious keratitis decreased from 11...
September 2, 2016: Scientific Reports
Anuradha Raj, Neeti Gupta, Renu Dhasmana, Ramesh Chander Nagpal, Harsh Bahadur, Amit Maitreya
INTRODUCTION: Corneal blindness forms significant proportion of visual blindness in developing countries and penetrating keratoplasty (PK) can restore vision for this. The prognosis of PK is dependent on the corneal diseases responsible for corneal blindness. AIM: To evaluate the indications and visual outcome of PK in tertiary eye care institute in Uttarakhand. MATERIALS AND METHODS: Data was reviewed from the medical records of 145 PK done in Department of Ophthalmology, Himalayan Institute of Medical Sciences from January 2012 to October 2014...
June 2016: Journal of Clinical and Diagnostic Research: JCDR
E M Messmer
Histopathological evaluation of ocular tissues is important in differentiating between infectious and autoimmune disease. Inflammation, necrosis and keratolysis are common to most forms of keratitis. Histopathology can be of great help in identifying the causative organism, establishing a final diagnosis and/or managing the patient with herpes simplex virus keratitis, mycotic keratitis, acanthamoeba keratitis or microsporidia keratoconjunctivitis. Important pathogenetic knowledge with therapeutic relevance has been gained from histopathological studies in nummular keratitis after epidemic keratoconjunctivitis and atopic keratoconjunctivitis...
July 2016: Klinische Monatsblätter Für Augenheilkunde
Mehrdad Malihi, Xintong Li, Shriji Patel, Thomas Eck, David S Chu, Marco A Zarbin, Neelakshi Bhagat
PURPOSE: To describe the demographics, characteristics, management, and outcomes of eyes with endophthalmitis related to infectious keratitis. METHODS: Retrospective chart review of all patients treated for infectious keratitis-associated infectious endophthalmitis between 2001 and 2014 at University Hospital, Rutgers New Jersey Medical School. RESULTS: Thirty-eight cases with infectious keratitis-associated infectious endophthalmitis were identified (21 men [55%], mean age: 66...
July 14, 2016: Retina
Onsiri Thanathanee, Wathanee Sripawadkul, Orapin Anutarapongpan, Patanaree Luanratanakorn, Olan Suwan-Apichon
PURPOSE: To report the surgical outcomes and complications of therapeutic penetrating keratoplasty (TPK) using glycerol-preserved corneas in infectious keratitis. METHODS: This is a retrospective, noncomparative case series of patients with severe infectious keratitis who received TPK using glycerol-preserved corneas from 2004 to 2014 in the Department of Ophthalmology, Srinagarind Hospital, Khon Kaen University. The medical records were reviewed for baseline characteristics, visual outcomes, recurrence rate, wound integrity, secondary glaucoma, and donor cornea storage times...
September 2016: Cornea
Soundaram MeenakshiSundaram, Aalia Rasool Sufi, N Venkatesh Prajna, Jeremy D Keenan
IMPORTANCE: In vivo confocal microscopy could be useful in cases of fungal or acanthamoeba keratitis to determine the depth of infectious elements, but its accuracy in determining corneal thickness relative to more traditional techniques has not been well characterized. OBSERVATIONS: In this cross-sectional observational case series, central corneal thickness was determined by in vivo confocal microscopy, ultrasonic pachymetry, and Scheimpflug topography in 47 normal corneas and 23 keratoconic corneas from November 2014 to July 2015...
September 1, 2016: JAMA Ophthalmology
Mozhgan Rezaei Kanavi, Mohammad Ali Javadi, Tahmineh Motevasseli, Tahereh Chamani, Mahnoush Rezaei Kanavi, Bahareh Kheiri, Sare Safi
PURPOSE: To report changing trends in indications and techniques of corneal transplantation in Iran. METHODS: We reviewed eye bank records of 47,129 patients who had undergone corneal transplantation between 2006 and 2013 at different eye centers throughout Iran. RESULTS: The most common indication for corneal transplantation was keratoconus (KCN, n = 21,350 eyes, 45.3%), followed by bullous keratopathy (BK, n = 8,566 eyes, 18.2%), corneal opacity and scar (COS, n = 7,158 eyes, 15...
April 2016: Journal of Ophthalmic & Vision Research
Clara C Chan, Lorena LoVerde, Judy Qiang, Michael L Nordlund, Edward J Holland
PURPOSE: To determine the rate of Boston type 1 keratoprosthesis (Kpro)-related corneal melts, leaks, and extrusions requiring surgical repair and to analyze possible risk factors and visual outcomes. METHODS: Retrospective chart review of 110 patients (128 eyes) who received a Kpro between November 2004 and December 2010 (average follow-up of 29 mo). The rate of corneal complications, risk factors for melts, and postmelt repair visual outcomes were evaluated. RESULTS: Twenty eyes from 18 patients developed Kpro-related melts requiring surgical repair...
August 2016: Cornea
Alireza Mashaghi, Jiaxu Hong, Sunil K Chauhan, Reza Dana
The prevalence of ocular surface immunopathologies is enhanced in the elderly. This increased prevalence has been attributed to age-related dysregulation of innate and adaptive immune system responses. Age-related changes in ocular surface immunity have similar and distinct characteristics to those changes seen in other mucosal tissues. This mini review provides a brief outline of key findings in the field of ocular ageing, draws comparisons with other mucosal tissues and, finally, discusses age-related changes in the context of immunopathogenesis of infectious keratitis and dry eye disease, two of the most common inflammatory disorders of the ocular surface...
July 4, 2016: British Journal of Ophthalmology
Jun Du, Guang-Ying Zheng, Cheng-Lin Wen, Xiao-Fang Zhang, Yu Zhu
AIM: To evaluate the clinical value of wedge resection at corneal limbus in patients with traumatic corneal scarring and high irregular astigmatism. METHODS: Patients with traumatic corneal astigmatism received wedge resection at least 6mo after suture removal from corneal wound. The uncorrected distance visual acuities (UCVA) and best corrected distance visual acuities (BCVA), pre- and post-operation astigmatism, spherical equivalent (SE), safety and complications were evaluated...
2016: International Journal of Ophthalmology
Ferdy R van Diemen, Elisabeth M Kruse, Marjolein J G Hooykaas, Carlijn E Bruggeling, Anita C Schürch, Petra M van Ham, Saskia M Imhof, Monique Nijhuis, Emmanuel J H J Wiertz, Robert Jan Lebbink
Herpesviruses infect the majority of the human population and can cause significant morbidity and mortality. Herpes simplex virus (HSV) type 1 causes cold sores and herpes simplex keratitis, whereas HSV-2 is responsible for genital herpes. Human cytomegalovirus (HCMV) is the most common viral cause of congenital defects and is responsible for serious disease in immuno-compromised individuals. Epstein-Barr virus (EBV) is associated with infectious mononucleosis and a broad range of malignancies, including Burkitt's lymphoma, nasopharyngeal carcinoma, Hodgkin's disease, and post-transplant lymphomas...
June 2016: PLoS Pathogens
Eric C Ledbetter, Patrick L McDonough, Kay Kim
OBJECTIVE: To describe clinical, in vivo confocal microscopic, histopathologic, and microbiologic features of canine and feline cases of infectious crystalline keratopathy (ICK). ANIMALS STUDIED: Six dogs and two cats with naturally acquired ICK. PROCEDURES: Medical records of dogs and cats with a clinical diagnosis of ICK were reviewed. Signalment, medical history, clinical findings, and diagnostic evaluations were retrieved, including corneal cytology, histopathology, in vivo confocal microscopy, and microbiology results...
June 29, 2016: Veterinary Ophthalmology
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