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Infectious keratitis

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https://www.readbyqxmd.com/read/28106466/phototoxic-effect-of-topical-fluoroquinolones-administered-before-corneal-crosslinking-in-a-murine-model
#1
Victor E Reviglio, Matias Osaba, Gabriela Sambuelli, Irene C Kuo
PURPOSE: Corneal crosslinking by UV light (UV-CXL) has become a popular treatment for keratoconus and corneal ectasia. Fluoroquinolones (FQs), commonly administered topically before UV-CXL, are known to be phototoxic to the skin and lens. The purpose of this study was to investigate phototoxic effects of topical FQ treatment on murine corneas before UV-CXL, in which the corneal epithelium was kept intact. METHODS: Murine corneas were treated with various antibiotics with or without riboflavin before UV-CXL...
January 20, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28092397/update-on-orthokeratology-in-managing-progressive-myopia-in-children-efficacy-mechanisms-and-concerns
#2
Xintong Li, Ilana B Friedman, Norman B Medow, Cheng Zhang
Myopia is an important public health issue, and high myopia may lead to severe complications if left untreated. Orthokeratology lenses, worn overnight to reshape the cornea, are one of many recent modalities used to slow down the progression of myopia in children. This treatment has been proven successful, as evidenced by decreased spherical refractive error and axial length relative to the control at interval follow-up ranging from 6 months to 5 years. In this systematic review, the authors collected published controlled studies that analyzed the efficacy of orthokeratology lens wear and calculated longitudinal relative changes in axial length, revealing a weighted average of -45...
January 13, 2017: Journal of Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28080168/corneal-melt-after-boston-keratoprosthesis-clinical-presentation-management-outcomes-and-risk-factor-analysis
#3
Soumaya Bouhout, Marie-Claude Robert, Sousans Deli, Mona Harissi-Dagher
PURPOSE: To determine the presentation, risk factors, and outcomes of keratolysis after Boston type I keratoprosthesis (B-KPro). METHODS: Retrospective chart review. RESULTS: A total of 16 (14%) of the 110 eyes (96 patients) which underwent B-KPro implantation developed keratolysis at an average 20 ± 11 months. Retroprosthetic membrane (RPM), infectious keratitis, and corneal dellen were identified in 31%, 25%, and 13% of corneal melts, respectively...
January 12, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28040524/corneal-higher-order-aberrations-in-infectious-keratitis
#4
Eisuke Shimizu, Takefumi Yamaguchi, Yukari Yaguchi, Murat Dogru, Yoshiyuki Satake, Kazuo Tsubota, Jun Shimazaki
PURPOSE: To characterize the corneal higher-order aberrations (HOAs) in eyes with acanthoamoeba keratitis (AK), bacterial keratitis (BK), and fungal keratitis (FK). DESIGN: Retrospective consecutive case series. METHODS: This retrospective study includes 18 normal subjects and 63 eyes of 62 consecutive patients with corneal scarring due to AK (20 eyes), BK (35 eyes) and FK (8 eyes) from 2010 to 2016. HOAs of the anterior and posterior surfaces and the total cornea were analyzed by anterior segment optical coherence tomography (AS-OCT)...
December 28, 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28003986/therapeutic-and-inducing-effect-of-corneal-crosslinking-on-infectious-keratitis
#5
REVIEW
Liang-Zhu Jiang, Shi-Yan Qiu, Zhi-Wei Li, Xiao Zhang, Xiang-Chen Tao, Guo-Ying Mu
The corneal crosslinking (CXL) with riboflavin and ultraviolet-A (UVA) is a new therapy method to successfully treat infectious keratitis in clinical practice. However, there are rare reports on the complications of CXL such as the secondary keratitis. The diverse clinical outcomes on keratitis have highlighted the necessity to further evaluate the efficacy and complications of CXL. We reviewed the positive and negative reports on UVA/riboflavin related with keratitis and provided our opinion on the therapeutic and side effect of UVA/riboflavin crosslinking on keratitis...
2016: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28002114/treatment-of-pseudomonas-keratitis-by-continuous-infusion-of-topical-antibiotics-with-the-morgan-lens
#6
Mingwu Wang, Whitney A Smith, Joshua K Duncan, Joseph M Miller
PURPOSE: Despite following standard treatment, Pseudomonas keratitis can continue to progress and result in loss of vision or of the eye. Our cases demonstrate that the Morgan Lens can be an effective topical antibiotic delivery vehicle in advanced keratitis. METHODS: Two patients (3 eyes) with Pseudomonas keratitis were included in this report after failing to respond to intense inpatient topical treatment. Because loss of the eyes was imminent, the Morgan Lenses were used for continuous lavage with ceftazidime (50 mg/mL), in conjunction with other conventional treatment...
December 20, 2016: Cornea
https://www.readbyqxmd.com/read/28002111/outcome-of-therapeutic-penetrating-keratoplasty-using-glycerol-preserved-donor-corneas-in-infectious-keratitis
#7
Parul Chawla Gupta, Jagat Ram
No abstract text is available yet for this article.
December 20, 2016: Cornea
https://www.readbyqxmd.com/read/27998698/ocular-complications-in-survivors-of-the-ebola-outbreak-in-guinea
#8
Esther Hereth He'bert, Mamadou Oury Bah, Jean François E'tard, Mamadou Saliou Sow, Serge Resnikoff, Christine Fardeau, Abdoulaye Toure', Alexis Niouma Ouendeno, Isaac Ceougna Sagno, Laura March, Suzanne Izard, Pierre Louis Lama, Moumié Barry, Eric Delaporte
PURPOSE: The Ebola outbreak of 2013-2016 severely affected West Africa and resulted in 2544 deaths and 1270 survivors in Guinea, the country where it began. This Ebola virus was the Zaire strain of the virus family Filoviridae. In this outbreak the case fatality rate was about 67%. The survivors, declared cured after two negative blood PCR results, face psychosocial disorders, rheumatic, ear-nose-throat, neurocognitive, and ophthalmological complications. The goal of this study was to detect and describe ocular complications afflicting these survivors and to observe their occurrence and recurrences...
December 17, 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/27995356/tripartite-motif-8-trim8-positively-regulates-pro-inflammatory-responses-in-pseudomonas-aeruginosa-induced-keratitis-through-promoting-k63-linked-polyubiquitination-of-tak1-protein
#9
Litao Guo, Weili Dong, Xiaoxiao Fu, Jing Lin, Zhijun Dong, Xiaobo Tan, Tiemin Zhang
Pseudomonas aeruginosa (PA)-induced keratitis is a rapidly progressive ocular infectious disease that often leads to inflammatory epithelial edema, stromal infiltration, tissue destruction, corneal ulceration, and vision loss. In this study, we investigate the role of tripartite motif 8 (TRIM8) in regulating the inflammatory process of PA-induced keratitis. The expression of TRIM8 was increased in mouse corneas and in vitro-cultured macrophages after PA infection. Knockdown of the expression of TRIM8 significantly inhibited the activation of NF-κB signaling and decreased the production of pro-inflammatory cytokines both in vivo and in vitro after infected with PA...
December 19, 2016: Inflammation
https://www.readbyqxmd.com/read/27994804/microbial-profile-of-corneal-ulcers-in-a-tertiary-care-hospital-in-south-india
#10
Chittur Y Ranjini, Vishnu V Waddepally
PURPOSE: To identify the prevalence and microbial profile of infectious keratitis in a tertiary eye care hospital, and to test for the in vitro antimicrobial resistance of the bacterial isolates. METHODS: A total of 312 patients presenting to a tertiary eye care hospital with infected corneal ulcer were enrolled in this study. Their socio-demographic data and risk factors were recorded. Corneal scrapings collected from the edge of the ulcer were processed for direct gram stain and KOH mount...
October 2016: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/27989423/-diagnostic-and-therapeutic-contribution-of-microbiological-analysis-in-severe-microbial-keratitis-at-reims-university-hospital-between-2012%C3%A2-and-2014
#11
J Caliot, D Guindolet, A Ducasse, L Andreoletti, C Arndt
PURPOSE: To investigate the contribution of microbial analysis in the diagnosis and management of severe microbial keratitis. MATERIAL AND METHOD: This is a monocentric retrospective study at the University Hospital of Reims from January 2012 to December 2014. Corneal scrapings with infectious keratitis were subjected to routine bacterial and fungal culture. PCR was also performed to detect various viral DNA (VZV, CMV, EBV, HSV 1 & 2, adenovirus) and Acanthamoeba sp...
December 15, 2016: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/27987408/label-free-electrical-sensing-of-bacteria-in-eye-wash-samples-a-step-towards-point-of-care-detection-of-pathogens-in-patients-with-infectious-keratitis
#12
Hardik J Pandya, Manoj Kumar Kanakasabapathy, Saloni Verma, Manjyot Kaur Chug, Adnan Memic, Mihaela Gadjeva, Hadi Shafiee
The diagnosis of keratitis is based on visual exam, tissue cytology, and standard microbial culturing to determine the type of the infectious pathogen. To prescribe appropriate therapy, it is important to distinguish between bacterial, fungal, and viral keratitis, as the treatments are quite different. Diagnosis of the causative organism has a substantial prognostic importance. Further, timely knowledge of the nature of the pathogen is also critical to adapt therapy in patients unresponsive to empiric treatment options, which occurs in 10% of all cases...
December 13, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27982205/microbiological-and-epidemiological-study-of-infectious-keratitis-in-children-and-adolescents
#13
Maria Cecilia Zorat Yu, Ana Luisa Höfling-Lima, Guilherme Henrique Campos Furtado
Purpose: To analyze epidemiological and microbiological aspects of microbial keratitis in children and adolescents. Methods: This retrospective cohort study was conducted at the Department of Ophthalmology and Visual Science, Escola Paulista de Medicina, Universidade Federal de São Paulo, between July 15, 1975, and December 31, 2010. We analyzed corneal samples from 859 patients with clinical suspicion of infectious keratitis, comparing epidemiological and microbiological characteristics of bacterial keratitis with those of non-bacterial and non-viral keratitis...
September 2016: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/27977029/painful-acute-corneal-ulceration-and-anterior-stromal-keratitis-in-an-adolescent-with-reactive-arthritis
#14
Christopher J Lyons, Elham AlQahtani, Hughie Tsang, Gregory T Moloney, Jane Gardiner
Reactive arthritis is occasionally associated with conjunctivitis and uveitis, but rarely keratitis. The authors describe a patient with paracentral anterior stromal keratitis with overlying epithelial erosion and multiple satellite subepithelial infiltrates. The initial appearance and the severe pain were suggestive of an infectious process. Recovery was rapid following introduction of topical steroid, with features suggesting an immune process in the recovery phase. The authors suggest that a history of arthritis and/or recent enteritis should be sought in the work-up of an atypical keratitis with or without epithelial defect...
December 8, 2016: Journal of Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/27960579/genus-distribution-of-bacteria-and-fungi-associated-with-keratitis-in-a-large-eye-center-located-in-southern-china
#15
Lixia Lin, Weizhong Lan, Bingsheng Lou, Hongmin Ke, Yuanzhe Yang, Xiaofeng Lin, Lingyi Liang
PURPOSE: To investigate the genus distribution of bacteria and fungi associated with keratitis in a large eye center located in Southern China and to compare the results with existing data from other areas in China. METHODS: All results of corneal microbiological examinations from 2009 to 2013 of patients who had been clinically diagnosed with bacterial or fungal keratitis were obtained chronologically and anonymously from the microbiology database at Zhongshan Ophthalmic Center...
December 14, 2016: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/27902849/oral-antivirals-for-preventing-recurrent-herpes-simplex-keratitis-in-people-with-corneal-grafts
#16
REVIEW
Uday K Bhatt, M N Abdul Karim, Jeremy I Prydal, Senthil V Maharajan, Usama Fares
BACKGROUND: Ocular herpes is a viral infection of the eye caused by the herpes simplex virus (HSV), a double-stranded DNA virus. Corneal scarring caused by herpes simplex keratitis (HSK) is the leading infectious cause of penetrating corneal graft in high-income countries. Acyclovir is an antiviral drug known to have a protective effect against recurrences in herpetic eye disease. While there are some studies which have evaluated the effects of intervention with oral antiviral in preventing such recurrences in people with corneal grafts, a systematic review of all comparative clinical trials has not been previously undertaken...
November 30, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27896784/ocular-involvement-associated-with-varicella-in-adults
#17
Salma Gargouri, Sana Khochtali, Sourour Zina, Molka Khairallah, Imen Zone-Abid, Imen Kaibi, Salim Ben Yahia, Jamel Feki, Moncef Khairallah
BACKGROUND: Varicella is a common infectious disease primarily of childhood that is usually benign and self-limited. It is, however, increasingly seen in adults who are at a higher risk of severe infection. Ocular complications of varicella are relatively uncommon and have been rarely described in adults. We describe herein five adults who developed ocular involvement in association with primary varicella-zoster virus infection. FINDINGS: Ocular manifestations included acute anterior uveitis in four eyes, with associated stromal keratitis in one of them, epithelial ulcerative keratitis in the two eyes of one patient, and acute retinal necrosis in one eye...
December 2016: Journal of Ophthalmic Inflammation and Infection
https://www.readbyqxmd.com/read/27893743/trends-of-bacterial-keratitis-culture-isolates-in-jerusalem-a-13-years-analysis
#18
Michael Politis, Denise Wajnsztajn, Boris Rosin, Colin Block, Abraham Solomon
PURPOSE: To describe the trends in pathogens and antibacterial resistance of corneal culture isolates in infectious keratitis during a period of 13 years at Hadassah-Hebrew University Medical Center. METHODS: A Retrospective analysis of bacterial corneal isolates was performed during the months of January 2002 to December 2014 at Hadassah Hebrew University Medical Center. Demographics, microbiological data and antibiotic resistance and sensitivity were collected...
2016: PloS One
https://www.readbyqxmd.com/read/27863549/cytokine-and-chemokine-profiles-of-aqueous-humor-and-serum-in-horses-with-uveitis-measured-using-multiplex-bead-immunoassay-analysis
#19
Elizabeth Curto, Kristen M Messenger, Jacklyn H Salmon, Brian C Gilger
OBJECTIVE: To determine whether horses with clinically diagnosed Equine Recurrent Uveitis (ERU) and those with Leptospirosis infection have a specific cytokine profile in their aqueous humor (AH) and serum that differs from horses with uveitis secondary to other ocular inflammatory processes and from horses with normal eyes. ANIMALS STUDIED: Twenty-five client-owned horses with uveitis that were presented to the North Carolina State University Ophthalmology Service, and four University-owned horses without history or clinical signs of ocular disease...
December 2016: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/27836717/therapeutic-agents-and-biocides-for-ocular-infections-by-free-living-amoebae-of-acanthamoeba-genus
#20
REVIEW
Linda Christian Carrijo-Carvalho, Viviane Peracini Sant'ana, Annette Silva Foronda, Denise de Freitas, Fabio Ramos de Souza Carvalho
Acanthamoeba keratitis is a sight-threatening infectious disease. Resistance of the cystic form of the protozoan to biocides and the potential toxicity of chemical compounds to corneal cells are the main concerns related to long-term treatment with the clinically available ophthalmic drugs. Currently, a limited number of recognized antimicrobial agents are available to treat ocular amoebic infections. Topical application of biguanide and diamidine antiseptic solutions is the first-line therapy. We consider the current challenges when treating Acanthamoeba keratitis and review the chemical properties, toxicities, and mechanisms of action of the available biocides...
November 9, 2016: Survey of Ophthalmology
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