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Microbial keratitis

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https://www.readbyqxmd.com/read/29676320/unveiling-opacification-of-intraocular-lens-following-a-successful-penetrating-keratoplasty-for-extensively-scarred-cornea-due-to-microbial-keratitis-after-descemet-s-stripping-automated-endothelial-keratoplasty
#1
https://www.readbyqxmd.com/read/29663139/corneal-biopsy-for-diagnosis-of-recalcitrant-microbial-keratitis
#2
Dana Robaei, U-Teng Chan, Pauline Khoo, Svetlana Cherepanoff, Yi-Chiao Li, Jane Hanrahan, Stephanie Watson
PURPOSE: To document the findings of corneal biopsies for progressive microbial keratitis in a large tertiary referral institution. METHODS: A retrospective medical records review of all patients who underwent at least one corneal biopsy for the diagnosis of microbial keratitis at Sydney Eye Hospital, Australia between January 1, 2010 and December 31, 2016 was performed. RESULTS: Thirty-eight patients (18 men and 20 women) underwent a corneal biopsy for progressive microbial keratitis unresponsive to broad-spectrum topical antimicrobials...
April 16, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29625447/imaging-of-corneal-neovascularization-optical-coherence-tomography-angiography-and-fluorescence-angiography
#3
Matthias Brunner, Vito Romano, Bernhard Steger, Riccardo Vinciguerra, Samuel Lawman, Bryan Williams, Nicholas Hicks, Gabriela Czanner, Yalin Zheng, Colin E Willoughby, Stephen B Kaye
Purpose: The purpose of this study was to compare optical coherence tomography angiography (OCTA) and indocyanine green angiography (ICGA) for the assessment of corneal neovascularization (CoNV). Methods: Patients with CoNV extending at least 3 mm into the cornea were included. All patients underwent corneal imaging at the same visit. Images were recorded using the AngioVue OCTA system (Optovue, Inc.) with the long corneal adaptor module (CAM-L). ICGA images were recorded with fluorescent filters using the Heidelberg system (HRA2 Scanning Laser Ophthalmoscope; Heidelberg Engineering)...
March 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29580152/epidemiology-risk-factors-and-clinical-outcomes-in-severe-microbial-keratitis-in-south-india
#4
Jaya Devi Chidambaram, Namperumalsamy Venkatesh Prajna, Palepu Srikanthi, Shruti Lanjewar, Manisha Shah, Shanmugam Elakkiya, Prajna Lalitha, Matthew J Burton
PURPOSE: Here, we report risk factors associated with outcome in severe bacterial keratitis (BK), fungal keratitis (FK), and Acanthamoeba keratitis (AK) in India. METHODS: Prospective observational cohort study conducted in Aravind Eye Hospital, India. Adults presenting with severe microbial keratitis (MK) were enrolled (size ≥3 mm) and followed to 21 days post-enrolment. Ulcer clinical features were recorded at presentation. Outcomes by final visit were classified as good (completely healed or reduced infiltrate size) or poor (enlarged infiltrate size, perforated, or surgery performed)...
March 26, 2018: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/29550185/in-vivo-confocal-microscopy-cellular-features-of-host-and-organism-in-bacterial-fungal-and-acanthamoeba-keratitis
#5
Jaya D Chidambaram, Namperumalsamy V Prajna, Srikanthi Palepu, Shruti Lanjewar, Manisha Shah, Shanmugam Elakkiya, David Macleod, Prajna Lalitha, Matthew J Burton
PURPOSE: To determine cellular features of fungal (FK), Acanthamoeba (AK) and bacterial keratitis (BK) using HRT3 in vivo confocal microscopy (IVCM). DESIGN: Prospective observational cross-sectional study. METHODS: Eligible participants were adults with microbiologically-positive FK, AK or BK, of size ≥3mm attending Aravind Eye Hospital from Feb 2012 to Feb 2013. EXCLUSION CRITERIA: descemetocele, perforation. At presentation, IVCM imaging was performed, then corneal scrapes obtained for culture/light microscopy...
March 14, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29514379/-in-vitro-study-of-subablative-er-yag-laser-and-diode-laser-therapy-vs-thermal-cautery-in-microbial-keratitis
#6
Jürgen Kampmeier, Jens Ulrich Werner, Peter Wagner, Gerhard K Lang, Detlef Russ
BACKGROUND: In microbial keratitis, thermal cautery leads to thermal necrosis associated with germ reduction. Subablative heating of the cornea using an Er : YAG laser or diode laser is an alternative option. Thermal effects and reproducibility of both procedures were investigated. MATERIAL AND METHODS: Thermal effects were monitored with an infrared imaging system. Temperature of stromal tissue of enucleated porcine eyes was measured. Effects of thermal injury were rated by microscopic photography and histopathologic examination...
March 7, 2018: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29490392/-microbial-keratitis-part-2-specific-aspects-of-mycotic-and-acanthamoeba-keratitis
#7
Ingo Schmack, Michael Müller, Thomas Kohnen
No abstract text is available yet for this article.
February 28, 2018: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29490391/-microbial-keratitis-understand-recognize-and-treat-part-1-general-aspects-and-characteristics-of-bacterial-keratitis
#8
Ingo Schmack, Michael Müller, Thomas Kohnen
Infectious inflammation of the cornea (microbial keratitis) represents a potentially vision threatening disease. Depending on the infectious agent and the course of the disease it can result in a complete loss of the involved eye. Early diagnosis and accurate treatment are mandatory to maintain a sufficient visual acuity. The purpose of this review is to highlight and discuss characteristic clinical features, diagnostic procedures, and therapeutic aspects of three major forms of microbial keratitis (bacteria, fungi, and acanthamoeba; the latter two in the 2nd part of this article)...
February 28, 2018: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29429293/-deep-anterior-lamellar-keratoplasty-combined-with-antiviral-therapy-in-the-treatment-of-severe-herpes-necrotizing-stromal-keratitis
#9
S X Li, J T Wang, Y Jiang, X Wang, W Y Shi
Objective: To evaluate the efficacy of modified deep lamellar keratoplasty (DLKP) combined with antiviral medications for severe herpes necrotizing stromal keratitis. Methods: Retrospective case series study. Modified DLKP was performed in combination with antiviral medications in fifty patients (50 eyes) with severe necrotizing stromal keratitis, which was unresponsive to systemic and topical antiviral treatment for 1 week, at Shandong Eye Hospital. Before surgery, the operated eyes were examined using slit-lamp microscopy...
February 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29423784/ocular-surface-squamous-neoplasia-in-a-setting-of-fungal-keratitis-a-rare-co-occurrence
#10
Swati Singh, Ruchi Mittal, Purvasha Narang, Vikas Mittal
PURPOSE: To describe a rare co-occurrence of ocular surface squamous neoplasia (OSSN) in a patient with microbial keratitis. METHODS: Case report. RESULTS: We describe a 68-years female who developed ocular surface squamous neoplasia (OSSN) in an eye with culture proven severe fungal keratitis of 5 months duration, which progressed to endophthalmitis. She was managed with extended enucleation for left eye. Histopathology examination was consistent with squamous cell carcinoma of ocular surface with no corneal stromal/scleral/anterior chamber involvement...
February 8, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29412494/the-rising-tide-of-acanthamoeba-keratitis-in-auckland-new-zealand-a-7-year-review-of-presentation-diagnosis-and-outcomes-2009-2016
#11
James McKelvie, Moaz Alshiakhi, Mohammed Ziaei, Dipika V Patel, Charles Nj McGhee
IMPORTANCE: Acanthamoeba is an increasingly prevalent cause of vision-threatening microbial keratitis. BACKGROUND: To assess the incidence, clinical presentation, diagnosis and outcomes of patients with Acanthamoeba keratitis (AK) in Auckland, New Zealand over a 7-year period. DESIGN: Retrospective observational consecutive case series. PARTICIPANTS: Fifty-eight eyes of 52 patients diagnosed with AK. METHODS: All cases of AK were identified using a cross-referenced search of clinical, laboratory and pharmacy records from March 2009 to May 2016...
February 7, 2018: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/29390396/acute-keratoconjunctivitis-due-to-contamination-of-contact-lens-care-solution-with-histamine-producing-raoultella-species-a-case-report
#12
Hiroshi Eguchi, Fumika Hotta, Tomomi Kuwahara, Haruyuki Nakayama-Imaohji, Shunji Kusaka, Yoshikazu Shimomura
RATIONALE: Contact lens storage cases are known to be contaminated by a significant number of bacteria. However, histamine-producing Raoultella species has not been reported to contaminate contact lens storage case. PATIENT CONCERNS: A 27-year-old woman with keratoconjunctivitis that developed in the left eye owing to a cosmetic contact lens and poor hygiene was referred to our hospital. The corrected visual acuity was hand motion. DIAGNOSES: Corneal infection other than Acanthamoeba keratitis (AK) and corneal hypoxia were excluded...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29386617/microbial-keratitis-in-corneal-grafts-predisposing-factors-and-outcomes
#13
A C O Okonkwo, W F Siah, H D J Hogg, H Anwar, F C Figueiredo
PurposeTo identify the nature of microbial keratitis in corneal grafts and the clinical outcomes at a tertiary hospital in the United Kingdom.Patients and methodsA retrospective case series of microbial keratitis in corneal grafts at the Royal Victoria Infirmary, Newcastle upon Tyne over a 17-year period (1997-2014).ResultsA total of 759 consecutive corneal grafts were identified from the Cornea Transplantation database. Of these, 59 episodes of microbial keratitis occurred in 41 eyes of 41 patients (5.4%; 19 male, 46...
January 26, 2018: Eye
https://www.readbyqxmd.com/read/29371536/reduced-multidrug-susceptibility-profile-is-a-common-feature-of-opportunistic-fusarium-species-fusarium-multi-drug-resistant-pattern
#14
REVIEW
Saad J Taj-Aldeen
The resistance among various opportunistic Fusarium species to different antifungal agents has emerged as a cause of public health problems worldwide. Considering the significance of multi-drug resistant (MDR), this paper emphasizes the problems associated with MDR and the need to understand its clinical significance to combat microbial infections. The search platform PubMed/MEDLINE and a review of 32 cases revealed a common multidrug-resistant profile exists, and clinically relevant members of Fusarium are intrinsically resistant to most currently used antifungals...
April 10, 2017: Journal of Fungi (Basel, Switzerland)
https://www.readbyqxmd.com/read/29371064/metagenomic-analysis-for-detecting-fusarium-solani-in-a-case-of-fungal-keratitis
#15
Chika Shigeyasu, Masakazu Yamada, Kotaro Aoki, Yoshikazu Ishii, Kazuhiro Tateda, Takashi Yaguchi, Yukinobu Okajima, Yuichi Hori
PURPOSE: To report a difficult-to-identify case of keratitis due to Fusarium solani, diagnosed with the help of exhaustive gene analysis. CASE: A 47-year-old woman attended our hospital with a refractory corneal ulcer associated with contact lens wear in her left eye that had appeared two weeks earlier. On her initial visit, slit lamp examination revealed a small double-ringed irregular hyphate ulcer in the center of the cornea, which had no epithelial defect, suggesting fungal infection...
January 20, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29369229/stenotrophomonas-maltophilia-a-case-series-of-a-rare-keratitis-affecting-patients-with-bandage-contact-lens
#16
Henry D J Hogg, We Fong Siah, Arthur Okonkwo, Manjusha Narayanan, Francisco C Figueiredo
OBJECTIVES: Stenotrophomonas maltophilia is an opportunistic pathogen known to form biofilms on contact lens and case surfaces that may result in permanent visual loss in cases of microbial keratitis. Because of its multiple drug resistance and extremely low incidence, there is little consensus on treatment. We investigated the predisposing factors, management, and visual outcomes in a small case series of patients to better inform the management of this rarely reported keratitis. METHODS: Retrospective analysis of medical records was performed at a single tertiary referral center between 2011 and 2017...
January 22, 2018: Eye & Contact Lens
https://www.readbyqxmd.com/read/29340642/identifying-corneal-infections-in-formalin-fixed-specimens-using-next-generation-sequencing
#17
Zhigang Li, Florian P Breitwieser, Jennifer Lu, Albert S Jun, Laura Asnaghi, Steven L Salzberg, Charles G Eberhart
Purpose: We test the ability of next-generation sequencing, combined with computational analysis, to identify a range of organisms causing infectious keratitis. Methods: This retrospective study evaluated 16 cases of infectious keratitis and four control corneas in formalin-fixed tissues from the pathology laboratory. Infectious cases also were analyzed in the microbiology laboratory using culture, polymerase chain reaction, and direct staining. Classified sequence reads were analyzed with two different metagenomics classification engines, Kraken and Centrifuge, and visualized using the Pavian software tool...
January 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29326852/unusual-course-of-crystalline-keratopathy-in-a-patient-with-graft-versus-host-disease
#18
Başak Bostancı, Yonca Aydın Akova
We present a case of infectious crystalline keratopathy in a patient with Graft-versus-Host disease (GVHD) who developed satellite fungal keratitis. A 51-year-old man was referred for bilateral total persistent corneal epithelial defects with severe dry eye. Although persistent epithelial defect healed with medical therapy, he developed stromal keratitis with satellite lesions confirmed to be secondary to Candida albicans. After three months of antifungal treatment and debridement, improvement of the infiltrates was obtained...
December 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/29308960/collagen-cross-linking-in-the-management-of-microbial-keratitis
#19
Chiara Bonzano, Antonio Di Zazzo, Stefano Barabino, Giulia Coco, Carlo Enrico Traverso
Increasing resistance to antimicrobial agents has contributed to an elevated risk of complications of infectious keratitis. Corneal collagen cross-linking (CXL) has been widely adopted for the management of keratoconus and post-refractive surgery corneal ectasia. It has recently been introduced as an option for treating keratitis due to multidrug resistant organisms. The purpose of this review is to discuss the rationale, safety, and evidence for CXL in infectious keratitis and its possible effect on ocular surface inflammation...
January 8, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29273865/-tintelnotia-destructans-new-enemy-at-the-gates
#20
K J Habbe, A Frings, S Schrader, M Roth, C MacKenzie, G Walther, O Kurzai, G Geerling
Tintelnotia destructans is a fungal species described for the first time in 2016, which can cause infections of the nails and of the cornea. We describe the second known case worldwide of Tintelnotia destructans-associated keratitis and its therapy. A good sensitivity for amphotericin B and voriconazole was demonstrated in the resistogram for the first time and the successful clinical course was confirmed. The present case study also shows the importance of intensive diagnostics in atypical microbial keratitis...
December 22, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
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