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Microbial keratitis

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https://www.readbyqxmd.com/read/29429293/-deep-anterior-lamellar-keratoplasty-combined-with-antiviral-therapy-in-the-treatment-of-severe-herpes-necrotizing-stromal-keratitis
#1
S X Li, J T Wang, Y Jiang, X Wang, W Y Shi
Objective: To evaluate the efficacy of modified deep lamellar keratoplasty (DLKP) combined with antiviral medications for severe herpes necrotizing stromal keratitis. Methods: Retrospective case series study. Modified DLKP was performed in combination with antiviral medications in fifty patients (50 eyes) with severe necrotizing stromal keratitis, which was unresponsive to systemic and topical antiviral treatment for 1 week, at Shandong Eye Hospital. Before surgery, the operated eyes were examined using slit-lamp microscopy...
February 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29423784/ocular-surface-squamous-neoplasia-in-a-setting-of-fungal-keratitis-a-rare-co-occurrence
#2
Swati Singh, Ruchi Mittal, Purvasha Narang, Vikas Mittal
PURPOSE: To describe a rare co-occurrence of ocular surface squamous neoplasia (OSSN) in a patient with microbial keratitis. METHODS: Case report. RESULTS: We describe a 68-years female who developed ocular surface squamous neoplasia (OSSN) in an eye with culture proven severe fungal keratitis of 5 months duration, which progressed to endophthalmitis. She was managed with extended enucleation for left eye. Histopathology examination was consistent with squamous cell carcinoma of ocular surface with no corneal stromal/scleral/anterior chamber involvement...
February 8, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29412494/the-rising-tide-of-acanthamoeba-keratitis-in-auckland-new-zealand-a-7-year-review-of-presentation-diagnosis-and-outcomes-2009-2016
#3
James McKelvie, Moaz Alshiakhi, Mohammed Ziaei, Dipika V Patel, Charles Nj McGhee
IMPORTANCE: Acanthamoeba is an increasingly prevalent cause of vision-threatening microbial keratitis. BACKGROUND: To assess the incidence, clinical presentation, diagnosis and outcomes of patients with Acanthamoeba keratitis (AK) in Auckland, New Zealand over a 7-year period. DESIGN: Retrospective observational consecutive case series. PARTICIPANTS: Fifty-eight eyes of 52 patients diagnosed with AK. METHODS: All cases of AK were identified using a cross-referenced search of clinical, laboratory and pharmacy records from March 2009 to May 2016...
February 7, 2018: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/29390396/acute-keratoconjunctivitis-due-to-contamination-of-contact-lens-care-solution-with-histamine-producing-raoultella-species-a-case-report
#4
Hiroshi Eguchi, Fumika Hotta, Tomomi Kuwahara, Haruyuki Nakayama-Imaohji, Shunji Kusaka, Yoshikazu Shimomura
RATIONALE: Contact lens storage cases are known to be contaminated by a significant number of bacteria. However, histamine-producing Raoultella species has not been reported to contaminate contact lens storage case. PATIENT CONCERNS: A 27-year-old woman with keratoconjunctivitis that developed in the left eye owing to a cosmetic contact lens and poor hygiene was referred to our hospital. The corrected visual acuity was hand motion. DIAGNOSES: Corneal infection other than Acanthamoeba keratitis (AK) and corneal hypoxia were excluded...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29386617/microbial-keratitis-in-corneal-grafts-predisposing-factors-and-outcomes
#5
A C O Okonkwo, W F Siah, H D J Hogg, H Anwar, F C Figueiredo
PurposeTo identify the nature of microbial keratitis in corneal grafts and the clinical outcomes at a tertiary hospital in the United Kingdom.Patients and methodsA retrospective case series of microbial keratitis in corneal grafts at the Royal Victoria Infirmary, Newcastle upon Tyne over a 17-year period (1997-2014).ResultsA total of 759 consecutive corneal grafts were identified from the Cornea Transplantation database. Of these, 59 episodes of microbial keratitis occurred in 41 eyes of 41 patients (5.4%; 19 male, 46...
January 26, 2018: Eye
https://www.readbyqxmd.com/read/29371536/reduced-multidrug-susceptibility-profile-is-a-common-feature-of-opportunistic-fusarium-species-fusarium-multi-drug-resistant-pattern
#6
REVIEW
Saad J Taj-Aldeen
The resistance among various opportunistic Fusarium species to different antifungal agents has emerged as a cause of public health problems worldwide. Considering the significance of multi-drug resistant (MDR), this paper emphasizes the problems associated with MDR and the need to understand its clinical significance to combat microbial infections. The search platform PubMed/MEDLINE and a review of 32 cases revealed a common multidrug-resistant profile exists, and clinically relevant members of Fusarium are intrinsically resistant to most currently used antifungals...
April 10, 2017: Journal of Fungi (Basel, Switzerland)
https://www.readbyqxmd.com/read/29371064/metagenomic-analysis-for-detecting-fusarium-solani-in-a-case-of-fungal-keratitis
#7
Chika Shigeyasu, Masakazu Yamada, Kotaro Aoki, Yoshikazu Ishii, Kazuhiro Tateda, Takashi Yaguchi, Yukinobu Okajima, Yuichi Hori
PURPOSE: To report a difficult-to-identify case of keratitis due to Fusarium solani, diagnosed with the help of exhaustive gene analysis. CASE: A 47-year-old woman attended our hospital with a refractory corneal ulcer associated with contact lens wear in her left eye that had appeared two weeks earlier. On her initial visit, slit lamp examination revealed a small double-ringed irregular hyphate ulcer in the center of the cornea, which had no epithelial defect, suggesting fungal infection...
January 20, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29369229/stenotrophomonas-maltophilia-a-case-series-of-a-rare-keratitis-affecting-patients-with-bandage-contact-lens
#8
Henry D J Hogg, We Fong Siah, Arthur Okonkwo, Manjusha Narayanan, Francisco C Figueiredo
OBJECTIVES: Stenotrophomonas maltophilia is an opportunistic pathogen known to form biofilms on contact lens and case surfaces that may result in permanent visual loss in cases of microbial keratitis. Because of its multiple drug resistance and extremely low incidence, there is little consensus on treatment. We investigated the predisposing factors, management, and visual outcomes in a small case series of patients to better inform the management of this rarely reported keratitis. METHODS: Retrospective analysis of medical records was performed at a single tertiary referral center between 2011 and 2017...
January 22, 2018: Eye & Contact Lens
https://www.readbyqxmd.com/read/29340642/identifying-corneal-infections-in-formalin-fixed-specimens-using-next-generation-sequencing
#9
Zhigang Li, Florian P Breitwieser, Jennifer Lu, Albert S Jun, Laura Asnaghi, Steven L Salzberg, Charles G Eberhart
Purpose: We test the ability of next-generation sequencing, combined with computational analysis, to identify a range of organisms causing infectious keratitis. Methods: This retrospective study evaluated 16 cases of infectious keratitis and four control corneas in formalin-fixed tissues from the pathology laboratory. Infectious cases also were analyzed in the microbiology laboratory using culture, polymerase chain reaction, and direct staining. Classified sequence reads were analyzed with two different metagenomics classification engines, Kraken and Centrifuge, and visualized using the Pavian software tool...
January 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29326852/unusual-course-of-crystalline-keratopathy-in-a-patient-with-graft-versus-host-disease
#10
Başak Bostancı, Yonca Aydın Akova
We present a case of infectious crystalline keratopathy in a patient with Graft-versus-Host disease (GVHD) who developed satellite fungal keratitis. A 51-year-old man was referred for bilateral total persistent corneal epithelial defects with severe dry eye. Although persistent epithelial defect healed with medical therapy, he developed stromal keratitis with satellite lesions confirmed to be secondary to Candida albicans. After three months of antifungal treatment and debridement, improvement of the infiltrates was obtained...
December 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/29308960/collagen-cross-linking-in-the-management-of-microbial-keratitis
#11
Chiara Bonzano, Antonio Di Zazzo, Stefano Barabino, Giulia Coco, Carlo Enrico Traverso
Increasing resistance to antimicrobial agents has contributed to an elevated risk of complications of infectious keratitis. Corneal collagen cross-linking (CXL) has been widely adopted for the management of keratoconus and post-refractive surgery corneal ectasia. It has recently been introduced as an option for treating keratitis due to multidrug resistant organisms. The purpose of this review is to discuss the rationale, safety, and evidence for CXL in infectious keratitis and its possible effect on ocular surface inflammation...
January 8, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29273865/-tintelnotia-destructans-new-enemy-at-the-gates
#12
K J Habbe, A Frings, S Schrader, M Roth, C MacKenzie, G Walther, O Kurzai, G Geerling
Tintelnotia destructans is a fungal species described for the first time in 2016, which can cause infections of the nails and of the cornea. We describe the second known case worldwide of Tintelnotia destructans-associated keratitis and its therapy. A good sensitivity for amphotericin B and voriconazole was demonstrated in the resistogram for the first time and the successful clinical course was confirmed. The present case study also shows the importance of intensive diagnostics in atypical microbial keratitis...
December 22, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/29248979/application-of-modified-jdp-dgge-based-molecular-genotyping-method-to-predict-acanthamoeba-genotype-and-to-analyse-community-diversity-in-aquatic-environments
#13
Tsui-Kang Hsu, Jung-Sheng Chen, Bing-Mu Hsu, Yu-Pin Chen, Tsai-Hsueh Leu, Tung-Yi Huang, Yu-Wen Hsu, Shu-Fen Wu
Acanthamoeba spp. are ubiquitous, opportunistic potential human pathogens, causing granulomatous amoebic encephalitis and keratitis. They are classified as protozoa, and they include at least 20 different genotypes (T1-T20) based on variation in the 18S rRNA gene. Acanthamoeba spp. are diverse in their production of toxins and in their ability to resist environmental factors. Therefore, it is necessary to develop a rapid genotyping method for Acanthamoeba spp. in aquatic environments. Although the denaturing gradient gel electrophoresis (DGGE) method for analysing microbial genotypes is potentially useful for rapid identification of aquatic environmental species, the technique has been compromised by artificial DGGE profiles in which many DNA fragments of identical sequences are segregated and displayed as different bands...
December 17, 2017: Parasitology Research
https://www.readbyqxmd.com/read/29233457/antimicrobial-efficacy-of-a-novel-povidone-iodine-contact-lens-disinfection-system
#14
Katsuhide Yamasaki, Fumio Saito, Ritsue Ota, Simon Kilvington
PURPOSE: Contact lens (CL) wear is a risk factor for the acquisition of microbial keratitis. Accordingly, compliance to manufacturers' recommended hygiene and disinfection procedures are vital to safe (CL) use. In this study we evaluated a novel povidone-iodine (PI) (CL) disinfection system (cleadew, Ophtecs Corporation, Japan) against a range of bacterial, fungal and Acanthamoeba. METHODS: Antimicrobial assays were conducted according to ISO 14729 using the recommended strains of bacteria and fungi, with and without the presence of organic soil...
December 7, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/29227340/corneal-transplantation-in-new-zealand-2000-to-2009
#15
Alexandra Z Crawford, Thiyagaraj Krishnan, Susan E Ormonde, Dipika V Patel, Charles N McGhee
PURPOSE: To quantify all minor/major adverse events in a large cohort of consecutive corneal transplants, particularly in respect to penetrating keratoplasty (PKP). METHODS: All corneal transplants in the Auckland region over a 10-year period (2000-2009) were identified through the New Zealand National Eye Bank. Relevant clinical records were assessed for this period and 2 years after. All intraoperative or postoperative adverse events/complications, visual acuity, and graft outcomes were recorded...
December 8, 2017: Cornea
https://www.readbyqxmd.com/read/29135707/outcome-of-therapeutic-keratoplasty-in-hopeless-microbial-keratitis-cases-otherwise-advised-evisceration
#16
Rajat Jain, Karma L Bhutia, Neha Mohan, Col K C Gupta, Ashwani Ghai
PURPOSE: To study the outcome of therapeutic keratoplasty in severe microbial keratitis cases otherwise advised evisceration. METHODS: A retrospective, single-center clinical audit included 28 patients with severe microbial keratitis presenting from April 2014 to April 2016. Patients with microbial keratitis either affecting more than 2 quadrants of the limbus and/or cases with infections involving more than 180 mm of the cornea who were advised evisceration by more than one ophthalmologist were included...
February 2018: Cornea
https://www.readbyqxmd.com/read/29111996/microbial-keratitis-after-accelerated-corneal-collagen-cross-linking-in-keratoconus
#17
Prafulla K Maharana, Pranita Sahay, M Sujeeth, Deepali Singhal, Anubha Rathi, Jeewan S Titiyal, Namrata Sharma
PURPOSE: To assess the pattern of microbial keratitis after accelerated corneal collagen cross-linkage (aCXL) in patients with keratoconus. METHOD: The medical records of cases of keratoconus that underwent aCXL from June 2014 to May 2017 were reviewed. Cases that developed microbial keratitis after aCXL were included in the study. The clinical, microbiological profile and the treatment outcomes were evaluated. RESULTS: Of 532 eyes that underwent aCXL, 7 cases developed microbial keratitis during the study period...
November 2, 2017: Cornea
https://www.readbyqxmd.com/read/29111995/diagnostic-evaluation-of-co-occurrence-of-acanthamoeba-and-fungi-in-keratitis-a-preliminary-report
#18
Anita Raghavan, Shaffie Baidwal, Prabhu Vijayaraghavan, Sakthi Rajeswari, Revathi Rajaraman, Narendran Venkatapathy, Sunitha Menon, Ram Rammohan
PURPOSE: To test the hypothesis that the coexistence of Acanthamoeba with other forms of microbial keratitis, especially fungal keratitis (FK), is more prevalent than suspected. METHODS: A prospective diagnostic study whereby patients presenting with stromal keratitis were additionally tested for Acanthamoeba, irrespective of the initial diagnosis. In addition to the routine workup with Gram stain, KOH mount, and cultures on blood agar and potato dextrose agar, nonnutrient agar was included...
November 14, 2017: Cornea
https://www.readbyqxmd.com/read/29053557/bacterial-keratitis-isolated-organisms-and-antibiotic-resistance-patterns-in-san-francisco
#19
Michelle Y Peng, Vicky Cevallos, Stephen D McLeod, Thomas M Lietman, Jennifer Rose-Nussbaumer
PURPOSE: Understanding the spectrum of pathogens in a given geographic region is important when deciding on empiric antibiotic therapy. In this study, we evaluate the spectrum of bacterial organisms cultured from corneal samples and their antibiotic sensitivities to guide initial treatment of keratitis. METHODS: We performed a retrospective case review of cultures from suspected infectious keratitis cases at the Francis I. Proctor Foundation, University of California, San Francisco, from 1996 through 2015...
October 17, 2017: Cornea
https://www.readbyqxmd.com/read/29044738/overview-of-mechanisms-of-antibiotic-resistance-in-pseudomonas-aeruginosa-an-ocular-perspective
#20
REVIEW
Dinesh Subedi, Ajay Kumar Vijay, Mark Willcox
Treatment of Pseudomonas aeruginosa eye infections often becomes a challenge due to the ability of this bacterium to be resistant to antibiotics via intrinsic and acquired mechanisms. Transfer of resistance due to interchangeable genetic elements is an important mechanism for the rapid transfer of antibiotic resistance in this pathogen. As a result, drug-resistant strains are becoming increasingly prevalent worldwide. This review systematically analyses data from recent publications to describe the global prevalence and antibiotic sensitivity of ocular P...
October 18, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
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