keyword
MENU ▼
Read by QxMD icon Read
search

Microbial keratitis

keyword
https://www.readbyqxmd.com/read/27877016/clinical-utility-of-antimicrobial-susceptibility-measurement-plate-covering-formulated-concentrations-of-various-ophthalmic-antimicrobial-drugs
#1
Norihiko Tou, Ryohei Nejima, Yoshifumi Ikeda, Yuichi Hori, Kaoru Araki-Sasaki, Kazunori Miyata, Yoshitsugu Inoue, Akihiko Tawara
PURPOSE: The purpose of this study was to evaluate the clinical utility of SG17, an ophthalmic antimicrobial susceptibility measurement plate. DESIGN: This was a multicenter, retrospective, observational study. PATIENTS AND METHODS: Using clinical isolates from patients with ocular infections, drug susceptibility testing using the Clinical Laboratory and Standards Institute standards was routinely conducted at five facilities. The minimum inhibitory concentrations of the isolated strains were determined using SG17 at the Research Foundation for Microbial Diseases of Osaka University...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27844206/ex-vivo-rabbit-and-human-corneas-as-models-for-bacterial-and-fungal-keratitis
#2
Abigail Pinnock, Nagaveni Shivshetty, Sanhita Roy, Stephen Rimmer, Ian Douglas, Sheila MacNeil, Prashant Garg
PURPOSE: In the study of microbial keratitis, in vivo animal models often require a large number of animals, and in vitro monolayer cell culture does not maintain the three-dimensional structure of the tissues or cell-to-cell communication of in vivo models. Here, we propose reproducible ex vivo models of single- and dual-infection keratitis as an alternative to in vivo and in vitro models. METHODS: Excised rabbit and human corneoscleral rims maintained in organ culture were infected using 10(8) cells of Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans or Fusarium solani...
November 14, 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/27806431/contact-lens-wear-is-intrinsically-inflammatory
#3
REVIEW
Nathan Efron
Eye-care practitioners typically associate ocular inflammation during contact lens wear with serious complications such as microbial keratitis; however, more subtle mechanisms may be at play. This paper tests the notion that contact lens wear is intrinsically inflammatory by exploring whether uncomplicated contact lens wear meets the classical, clinical definition of inflammation - rubor (redness), calor (heat), tumor (swelling), dolor (pain) and functio laesa (loss of function) - as well as the contemporary, sub-clinical definition of inflammation (cellular and biochemical reactions)...
November 2, 2016: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/27768798/melimine-coated-antimicrobial-contact-lenses-reduce-microbial-keratitis-in-an-animal-model
#4
Debarun Dutta, Ajay K Vijay, Naresh Kumar, Mark D P Willcox
Purpose: To determine the ability of antimicrobial peptide melimine-coated contact lenses to reduce the incidence of microbial keratitis (MK) in a rabbit model of contact lens wear. Methods: In vitro antimicrobial activity of melimine-coated contact lenses was determined against Pseudomonas aeruginosa by viable count and a radiolabeled assay. The amount of lipopolysaccharide (LPS) associated with bacteria bound to melimine-coated and control lenses was determined...
October 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27755163/epidemiology-and-outcome-of-microbial-keratitis-private-university-versus-urban-public-hospital-care
#5
David T Truong, Minh-Thuy Bui, H Dwight Cavanagh
PURPOSE: To review the epidemiology, risk factors, microbiologic spectrum, and treatment of microbial keratitis during a 5-year period at an urban public hospital in comparison with an adjacent private university practice. METHODS: Retrospective chart review in the 5-year interval, 2009 through 2014. Primary outcome measures included patient age at presentation, best-corrected visual acuity (BCVA), risk factors, culture and sensitivities, treatment, and complication occurrence...
October 7, 2016: Eye & Contact Lens
https://www.readbyqxmd.com/read/27738866/the-comparison-of-antimicrobial-effectiveness-of-contact-lens-solutions
#6
Ali Kal, Mustafa Ilker Toker, Serpil Kaya
PURPOSE: The aim of this study was to compare the effects of widely used multipurpose contact lens solutions against Staphylococcus aureus and Pseudomonas aeruginosa, in addition to cystic and trophozoite forms of Acanthamoeba castellanii and A. polyphaga, that cause microbial keratitis. METHODS: Three multipurpose solutions were tested: SOLO-care, ReNu, and Opti-Free Express. The test solutions were challenged with P. aeruginosa (ATCC 27853) and S. aureus (ATCC 2913) based on the ISO stand-alone and regiment test procedure for disinfecting products, A...
October 13, 2016: International Ophthalmology
https://www.readbyqxmd.com/read/27688289/ocular-toxicity-by-seeds-of-annona-squamosa-custard-apple
#7
Harsha Nagaraja, Thungappa Kugar, Yathish Shivanna, Archita Agrawal, Rohit Shetty
Custard apple seeds have been used in native medicine from time immemorial for the management of head lice and skin exfoliation. We report six consecutive patients who developed toxic keratoconjunctivitis within 6-12 h of ocular exposure to custard apple seeds. The use of topical steroid worsens the toxicity and predisposes to the development of microbial keratitis in such cases. Patients showed a good response to primary treatment with topical fortified antibiotics and lubricants. This case series highlights the need to educate the patients regarding the potential toxic effects of the custard seeds and the treating physicians about possible deleterious effects on using topical steroid...
August 2016: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/27590660/identification-of-pathogenic-factors-potentially-involved-in-staphylococcus-aureus-keratitis-using-proteomics
#8
Shamila Khan, Nerida Cole, Emma B H Hume, Linda L Garthwaite, Terry Nguyen-Khuong, Bradley J Walsh, Mark D P Willcox
Staphylococcus is a leading cause of microbial keratitis, characterized by destruction of the cornea by bacterial exoproteins and host-associated factors. The aim of this study was to compare extracellular and cell-associated proteins produced by two different isolates of S. aureus, a virulent clinical isolate (Staph 38) and a laboratory strain (Staphylococcus aureus 8325-4) of weaker virulence in the mouse keratitis model. Proteins were analyzed using 2D polyacrylamide gel electrophoresis and identified by subsequent mass spectrometry...
October 2016: Experimental Eye Research
https://www.readbyqxmd.com/read/27576913/fungal-keratitis-in-patients-with-corneal-ulcer-attending-minilik-ii-memorial-hospital-addis-ababa-ethiopia
#9
Tihtina Kibret, Adane Bitew
BACKGROUND: Fungal keratitis is an important cause of corneal blindness all over the world. Although there are several reports on fungal keratitis from developing and developed countries, fungal keratitis in Ethiopia is poorly known. The aim of this study was to determine the prevalence of fungal keratitis and spectrum of fungi implicated in causing the infection. METHODS: The present study was a single institutional cross-sectional study carried out in Minilik II Memorial Hospital eye clinic, Addis Ababa, Ethiopia from September 2014 to August 2015...
August 30, 2016: BMC Ophthalmology
https://www.readbyqxmd.com/read/27541969/clinical-and-microbiological-profile-of-bacterial-microbial-keratitis-in-a-portuguese-tertiary-referral-center-where-are-we-in-2015
#10
Carla Sofia Ferreira, Luis Figueira, Nuno Moreira-Gonçalves, Raúl Moreira, Luis Torrão, Fernando Falcão-Reis
OBJECTIVES: To study the microbial profile, antibiotic susceptibility pattern, risk factors, therapeutic trends, and clinical outcomes for microbial keratitis (MK) in a tertiary health care center. METHODS: All cases with suspected bacterial keratitis that were followed at consultation from September 2007 to August 2015 were included. Microbial cultures were obtained and patients were managed following an internal protocol. RESULTS: Two hundred thirty-five patients were included, with a mean age of 50...
July 12, 2016: Eye & Contact Lens
https://www.readbyqxmd.com/read/27538797/prospective-study-of-the-diagnostic-accuracy-of-the-in%C3%A2-vivo-laser-scanning-confocal-microscope-for-severe-microbial-keratitis
#11
Jaya D Chidambaram, Namperumalsamy V Prajna, Natasha L Larke, Srikanthi Palepu, Shruti Lanjewar, Manisha Shah, Shanmugam Elakkiya, Prajna Lalitha, Nicole Carnt, Minna H Vesaluoma, Melanie Mason, Scott Hau, Matthew J Burton
PURPOSE: To determine the diagnostic accuracy of in vivo confocal microscopy (IVCM) for moderate to severe microbial keratitis (MK). DESIGN: Double-masked prospective cohort study. PARTICIPANTS: Consecutive patients presenting to Aravind Eye Hospital, Madurai, India, between February 2012 and February 2013 with MK (diameter ≥3 mm, excluding descemetocele, perforation, or herpetic keratitis). METHODS: Following examination, the corneal ulcer was scanned by IVCM (HRT3/RCM, Heidelberg Engineering, Heidelberg, Germany)...
August 15, 2016: Ophthalmology
https://www.readbyqxmd.com/read/27466717/serratia-liquefaciens-causing-severe-ocular-damage-in-noncontact-lens-wearer
#12
Akshatha Ranganatha, Mrinal Rana, Aidan Murray
Serratia liquefaciens is a rarely encountered gram-negative organism in ophthalmology practice. The only reported ocular infections are from contamination of contact lenses. The authors report the first case of a patient who developed orbital cellulitis secondary to severe S. liquefaciens microbial keratitis.
July 27, 2016: Eye & Contact Lens
https://www.readbyqxmd.com/read/27439630/vitamin-a-deficiency-and-xerophthalmia-in-children-of-a-developed-country
#13
Mimi Chiu, Alexander Dillon, Stephanie Watson
AIM: We aim (i) to characterise the clinical features of vitamin A deficiency (VAD) in a small cohort of Australian children; (ii) to determine the effects of VAD; and (iii) to quantify the prevalence of ophthalmic review in this group. METHODS: Data collected from the charts incorporated patient demographics, laboratory results, past medical history, ophthalmic symptoms and dietary history. Outcome measures were (i) occurrence of VAD in our study population; (ii) presence of associated systemic effects and ocular manifestations in those diagnosed with VAD; and (iii) determination of whether children with VAD had an ophthalmology review...
July 2016: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/27355655/risk-factors-for-ocular-burn-injuries-requiring-surgery
#14
Miguel S Cabalag, Jason Wasiak, Quaderi Syed, Eldho Paul, Anthony J Hall, Heather Cleland
The surgical management of severe ocular burns is challenging and often associated with variable long-term outcome. The aims of this study were to analyze the clinical course of these injuries and determine the factors associated with the need for surgery. A retrospective medical records review was conducted for patients admitted to the Victorian Adult Burns Services, with ocular burns, from January 2000 to January 2010. One hundred and twenty-nine patients were admitted with ocular burns, of which 17 (13.2%) required surgery...
June 22, 2016: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/27236644/clinical-and-corneal-microbial-profile-of-infectious-keratitis-in-a-high-hiv-prevalence-setting-in-rural-south-africa
#15
E Schaftenaar, R P H Peters, G S Baarsma, C Meenken, N S Khosa, S Getu, J A McIntyre, A D M E Osterhaus, G M G M Verjans
The purpose of this investigation was to determine the clinical and corneal microbial profile of infectious keratitis in a high human immunodeficiency virus (HIV) prevalence setting in rural South Africa. Data in this cross-sectional study were collected from patients presenting with symptoms of infectious keratitis (n = 46) at the ophthalmology outpatient department of three hospitals in rural South Africa. Corneal swabs were tested for herpes simplex virus type 1 (HSV-1) and 2 (HSV-2), varicella zoster virus (VZV) and adenovirus DNA by real-time polymerase chain reaction (PCR) and for bacteria and fungi by culture...
September 2016: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/27220229/collagen-crosslinking-in-the-management-of-microbial-keratitis
#16
Barac Ileana Ramona, Corbu Catalina, Merticariu Andrei, Stefan Daciana, Tataru Calin
OBJECTIVE: The evaluation of the efficiency of corneal cross linking in the management of corneal ulcers. METHOD: A prospective study that included 10 patients, 10 eyes, with chronic corneal ulcer, bacterial and/ or fungal. The patients were divided into two groups. Group A included 5 patients with unperforated corneal ulcer and group B included 5 patients with perforated corneal ulcer. These patients were treated with general and local antibiotic and antifungal drugs, but the response was poor after two weeks...
January 2016: Romanian Journal of Ophthalmology
https://www.readbyqxmd.com/read/27191669/acute-corneal-hydrops-complicated-by-microbial-keratitis-case-series-reveals-poor-immediate-and-long-term-prognosis
#17
Jay J Meyer, Charles N J McGhee
PURPOSE: Acute corneal hydrops is a rare complication of keratoconus and may be a risk factor for further complications such as microbial keratitis. METHODS: Retrospective, case series. RESULTS: Six eyes developed microbial keratitis during acute corneal hydrops. Risk factors for the development of microbial keratitis included epithelial defect, contact lens wear, trichiasis, and use of topical steroids. Two eyes developed corneal perforation and 1 eye was treated for possible endophthalmitis...
July 2016: Cornea
https://www.readbyqxmd.com/read/27176217/emerging-trends-in-contact-lens-related-infections
#18
Natalie Cheung, Parveen Nagra, Kristin Hammersmith
PURPOSE OF REVIEW: This article reviews the literature on past and recent trends in contact lens-related microbial keratitis from bacterial, fungal, and Acanthamoeba infections. RECENT FINDINGS: Contact lens wear is the most important risk factor for microbial keratitis. Despite increased use of daily disposable contact lens wear, the incidence of bacterial ulcers related to contact lens wear remains high. Overnight contact lens wear is the leading risk factor in contact lens-related bacterial infections...
July 2016: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/27139484/component-analysis-of-multipurpose-contact-lens-solutions-to-enhance-activity-against-pseudomonas-aeruginosa-and-staphylococcus-aureus
#19
Leo Lin, Janie Kim, Hope Chen, Regis Kowalski, Victor Nizet
More than 125 million people wear contact lenses worldwide, and contact lens use is the single greatest risk factor for developing microbial keratitis. We tested the antibacterial activity of multipurpose contact lens solutions and their individual component preservatives against the two most common pathogens causing bacterial keratitis, Pseudomonas aeruginosa and Staphylococcus aureus The in vitro antibacterial activity of five multipurpose contact lens solutions (Opti-Free GP, Boston Simplus, Boston Advance, Menicare GP, and Lobob) was assayed by the standard broth dilution method...
July 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27138637/infections-after-keratoprosthesis
#20
Emma Davies, James Chodosh
PURPOSE OF REVIEW: The purpose is to provide an overview of the recent advancements in the diagnosis and treatment of microbial keratitis and endophthalmitis after keratoprosthesis implantation. RECENT FINDINGS: The addition of vancomycin daily to a fluoroquinolone in the postoperative management of keratoprosthesis patients successfully reduced the number of cases of bacterial keratitis and endophthalmitis with an increased number of fungal infections now documented both in the United States and abroad...
July 2016: Current Opinion in Ophthalmology
keyword
keyword
25690
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"