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Microbial keratitis

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https://www.readbyqxmd.com/read/29891552/opposing-effects-of-il-1ra-and-il-36ra-on-innate-immune-response-to-pseudomonas-aeruginosa-infection-in-c57bl-6-mouse-corneas
#1
Nan Gao, Rao Me, Chenyang Dai, Berhane Seyoum, Fu-Shin X Yu
Pseudomonas aeruginosa keratitis is characterized by severe corneal ulceration and may lead to blindness if not treated properly in a timely manner. Although the roles of the IL-1 subfamily of cytokines are well established, as a newly discovered subfamily, IL-36 cytokine regulation, immunological relevance, and relation with IL-1 cytokines in host defense remain largely unknown. In this study, we showed that P. aeruginosa infection induces the expression of IL-36α and IL-36γ, as well as IL-1β and secreted IL-1Ra (sIL-1Ra), but not IL-36Ra...
June 11, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29881840/antibiotic-functionalised-polymers-reduce-bacterial-biofilm-and-bioburden-in-a-simulated-infection-of-the-cornea
#2
Natalya Doroshenko, Stephen Rimmer, Richard Hoskins, Prashant Garg, Thomas Swift, Hannah L M Spencer, Rianne M Lord, Maria Katsikogianni, David Pownall, Sheila MacNeil, C W Ian Douglas, Joanna Shepherd
Microbial keratitis can arise from penetrating injuries to the cornea. Corneal trauma promotes bacterial attachment and biofilm growth, which decrease the effectiveness of antimicrobials against microbial keratitis. Improved therapeutic efficacy can be achieved by reducing microbial burden prior to antimicrobial therapy. This paper assesses a highly-branched poly(N-isopropyl acrylamide) with vancomycin end groups (HB-PNIPAM-van), for reducing bacterial attachment and biofilm formation. The polymer lacked antimicrobial activity against Staphylococcus aureus, but significantly inhibited biofilm formation (p = 0...
June 8, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29859227/acanthamoeba-keratitis-an-emerging-disease-among-microbial-keratitis-in-the-cap-bon-region-of-tunisia
#3
W Zbiba, N Ben Abdesslem
INTRODUCTION: The aim of this study was to describe the prevalence of AK among microbial keratitis as well as their clinical features and to compare their risk factors to those of other infectious keratitis, over the last five years in a referral center in the region of Cap Bon, Tunisia, North Africa. METHODS: A retrospective review of the charts of 230 patients (230 eyes) diagnosed with presumed infectious keratitis between January 2011 and December 2016 at the department of ophthalmology of the university hospital of Nabeul in Tunisia...
May 30, 2018: Experimental Parasitology
https://www.readbyqxmd.com/read/29797413/evaluation-of-microbial-contamination-of-canine-plasma-eyedropper-bottles-following-clinical-use-in-canine-patients
#4
Rachel A Strauss, Ulrike Genschel, Rachel A Allbaugh, Lionel Sebbag, Gil Ben-Shlomo
OBJECTIVE: To investigate microbial contamination of canine plasma eye drops when used clinically and to compare the effect of two different eyedropper bottles on contamination rate. METHODS: Forty-six bottles containing plasma were randomly dispensed for use on 42 dogs with ulcerative keratitis. Of these, 23 were standard eyedropper bottles and 23 were Novelia® bottles designed to prevent contamination. After use for up to 2 weeks, samples for bacterial culture were obtained from a drop of plasma, the bottle tip, the plasma inside the bottle, and the corneal surface...
May 24, 2018: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/29724209/microbial-keratitis-induced-endophthalmitis-incidence-symptoms-therapy-visual-prognosis-and-outcomes
#5
Daniel Zapp, Daria Loos, Nikolaus Feucht, Ramin Khoramnia, Tamer Tandogan, Lukas Reznicek, Christian Mayer
BACKGROUND: To evaluate symptoms, therapies and outcomes in rare microbial keratitis-induced endophthalmitis. METHODS: Retrospective study with 11 patients treated between 2009 and 2014. Clinical findings, corneal diseases, history of steroids and trauma, use of contact lenses, number and type of surgical interventions, determination of causative organisms and visual acuity (VA) were evaluated. RESULTS: The incidence of transformation from microbial keratitis to an endophthalmitis was 0...
May 3, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29697492/acanthamoeba-an-overview-of-the-challenges-to-the-development-of-a-consensus-methodology-of-disinfection-efficacy-testing-for-contact-lens-care-products
#6
Jeffrey Brocious, Michelle E Tarver, Denise Hampton, Malvina Eydelman
With the increasing incidence of more pathogens that can cause microbial keratitis (MK), it is necessary to periodically reassess disinfection multipurpose solutions testing requirements to ensure that relevant organisms to challenge them are being used. Current testing protocols have included common pathogens such as Pseudomonas aeruginosa, Staphylococcus aureus, Serratia marcescens, Candida albicans, and Fusarium solani but have omitted less common pathogens such as Acanthamoeba. Specifically, Acanthamoeba sp...
April 24, 2018: Eye & Contact Lens
https://www.readbyqxmd.com/read/29687947/comparison-of-3-corneal-cytology-collection-methods-for-evaluating-equine-ulcerative-keratitis-cytobrush-kimura-platinum-spatula-and-handle-edge-of-scalpel-blade
#7
Laura Proietto, Sarah S Beatty, Caryn E Plummer
PURPOSE: To compare corneal cytology samples from three common sampling techniques: cytobrush (CB), Kimura platinum spatula (KS), and the handle edge of a scalpel blade (SB). METHODS: Equine patients presenting to the University of Florida College of Veterinary Medicine with ulcerative keratitis were included. Following diagnosis of corneal ulcer and sampling for microbial culture, two cytology samples per technique were collected with sterile CB, KS, and SB in a randomized order...
April 24, 2018: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/29676320/unveiling-opacification-of-intraocular-lens-following-a-successful-penetrating-keratoplasty-for-extensively-scarred-cornea-due-to-microbial-keratitis-after-descemet-s-stripping-automated-endothelial-keratoplasty
#8
https://www.readbyqxmd.com/read/29663139/corneal-biopsy-for-diagnosis-of-recalcitrant-microbial-keratitis
#9
Dana Robaei, U-Teng Chan, Pauline Khoo, Svetlana Cherepanoff, Yi-Chiao Li, Jane Hanrahan, Stephanie Watson
PURPOSE: To document the findings of corneal biopsies for progressive microbial keratitis in a large tertiary referral institution. METHODS: A retrospective medical records review of all patients who underwent at least one corneal biopsy for the diagnosis of microbial keratitis at Sydney Eye Hospital, Australia between January 1, 2010 and December 31, 2016 was performed. RESULTS: Thirty-eight patients (18 men and 20 women) underwent a corneal biopsy for progressive microbial keratitis unresponsive to broad-spectrum topical antimicrobials...
April 16, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29625447/imaging-of-corneal-neovascularization-optical-coherence-tomography-angiography-and-fluorescence-angiography
#10
Matthias Brunner, Vito Romano, Bernhard Steger, Riccardo Vinciguerra, Samuel Lawman, Bryan Williams, Nicholas Hicks, Gabriela Czanner, Yalin Zheng, Colin E Willoughby, Stephen B Kaye
Purpose: The purpose of this study was to compare optical coherence tomography angiography (OCTA) and indocyanine green angiography (ICGA) for the assessment of corneal neovascularization (CoNV). Methods: Patients with CoNV extending at least 3 mm into the cornea were included. All patients underwent corneal imaging at the same visit. Images were recorded using the AngioVue OCTA system (Optovue, Inc.) with the long corneal adaptor module (CAM-L). ICGA images were recorded with fluorescent filters using the Heidelberg system (HRA2 Scanning Laser Ophthalmoscope; Heidelberg Engineering)...
March 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29580152/epidemiology-risk-factors-and-clinical-outcomes-in-severe-microbial-keratitis-in-south-india
#11
Jaya Devi Chidambaram, Namperumalsamy Venkatesh Prajna, Palepu Srikanthi, Shruti Lanjewar, Manisha Shah, Shanmugam Elakkiya, Prajna Lalitha, Matthew J Burton
PURPOSE: Here, we report risk factors associated with outcome in severe bacterial keratitis (BK), fungal keratitis (FK), and Acanthamoeba keratitis (AK) in India. METHODS: Prospective observational cohort study conducted in Aravind Eye Hospital, India. Adults presenting with severe microbial keratitis (MK) were enrolled (size ≥3 mm) and followed to 21 days post-enrolment. Ulcer clinical features were recorded at presentation. Outcomes by final visit were classified as good (completely healed or reduced infiltrate size) or poor (enlarged infiltrate size, perforated, or surgery performed)...
March 26, 2018: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/29550185/in-vivo-confocal-microscopy-cellular-features-of-host-and-organism-in-bacterial-fungal-and-acanthamoeba-keratitis
#12
Jaya D Chidambaram, Namperumalsamy V Prajna, Srikanthi Palepu, Shruti Lanjewar, Manisha Shah, Shanmugam Elakkiya, David Macleod, Prajna Lalitha, Matthew J Burton
PURPOSE: To determine cellular features of fungal (FK), Acanthamoeba (AK), and bacterial keratitis (BK) using HRT3 in vivo confocal microscopy (IVCM). DESIGN: Prospective observational cross-sectional study. METHODS: Eligible participants were adults with microbiologically positive FK, AK, or BK, of size ≥ 3 mm, attending Aravind Eye Hospital from February 2012 to February 2013. Exclusion criteria were descemetocele or perforation. At presentation, IVCM imaging was performed, then corneal scrapes were obtained for culture/light microscopy...
June 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29514379/-in-vitro-study-of-subablative-er-yag-laser-and-diode-laser-therapy-vs-thermal-cautery-in-microbial-keratitis
#13
Jürgen Kampmeier, Jens Ulrich Werner, Peter Wagner, Gerhard K Lang, Detlef Russ
BACKGROUND: In microbial keratitis, thermal cautery leads to thermal necrosis associated with germ reduction. Subablative heating of the cornea using an Er : YAG laser or diode laser is an alternative option. Thermal effects and reproducibility of both procedures were investigated. MATERIAL AND METHODS: Thermal effects were monitored with an infrared imaging system. Temperature of stromal tissue of enucleated porcine eyes was measured. Effects of thermal injury were rated by microscopic photography and histopathologic examination...
March 7, 2018: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29490392/-microbial-keratitis-part-2-specific-aspects-of-mycotic-and-acanthamoeba-keratitis
#14
Ingo Schmack, Michael Müller, Thomas Kohnen
No abstract text is available yet for this article.
April 2018: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29490391/-microbial-keratitis-understand-recognize-and-treat-part-1-general-aspects-and-characteristics-of-bacterial-keratitis
#15
Ingo Schmack, Michael Müller, Thomas Kohnen
Infectious inflammation of the cornea (microbial keratitis) represents a potentially vision threatening disease. Depending on the infectious agent and the course of the disease it can result in a complete loss of the involved eye. Early diagnosis and accurate treatment are mandatory to maintain a sufficient visual acuity. The purpose of this review is to highlight and discuss characteristic clinical features, diagnostic procedures, and therapeutic aspects of three major forms of microbial keratitis (bacteria, fungi, and acanthamoeba; the latter two in the 2nd part of this article)...
March 2018: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29429293/-deep-anterior-lamellar-keratoplasty-combined-with-antiviral-therapy-in-the-treatment-of-severe-herpes-necrotizing-stromal-keratitis
#16
S X Li, J T Wang, Y Jiang, X Wang, W Y Shi
Objective: To evaluate the efficacy of modified deep lamellar keratoplasty (DLKP) combined with antiviral medications for severe herpes necrotizing stromal keratitis. Methods: Retrospective case series study. Modified DLKP was performed in combination with antiviral medications in fifty patients (50 eyes) with severe necrotizing stromal keratitis, which was unresponsive to systemic and topical antiviral treatment for 1 week, at Shandong Eye Hospital. Before surgery, the operated eyes were examined using slit-lamp microscopy...
February 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29423784/ocular-surface-squamous-neoplasia-in-a-setting-of-fungal-keratitis-a-rare-co-occurrence
#17
Swati Singh, Ruchi Mittal, Purvasha Narang, Vikas Mittal
PURPOSE: To describe a rare co-occurrence of ocular surface squamous neoplasia (OSSN) in a patient with microbial keratitis. METHODS: Case report. RESULTS: We describe a 68-years female who developed ocular surface squamous neoplasia (OSSN) in an eye with culture proven severe fungal keratitis of 5 months duration, which progressed to endophthalmitis. She was managed with extended enucleation for left eye. Histopathology examination was consistent with squamous cell carcinoma of ocular surface with no corneal stromal/scleral/anterior chamber involvement...
February 8, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29412494/the-rising-tide-of-acanthamoeba-keratitis-in-auckland-new-zealand-a-7-year-review-of-presentation-diagnosis-and-outcomes-2009-2016
#18
James McKelvie, Moaz Alshiakhi, Mohammed Ziaei, Dipika V Patel, Charles Nj McGhee
IMPORTANCE: Acanthamoeba is an increasingly prevalent cause of vision-threatening microbial keratitis. BACKGROUND: To assess the incidence, clinical presentation, diagnosis and outcomes of patients with Acanthamoeba keratitis (AK) in Auckland, New Zealand over a 7-year period. DESIGN: Retrospective observational consecutive case series. PARTICIPANTS: Fifty-eight eyes of 52 patients diagnosed with AK. METHODS: All cases of AK were identified using a cross-referenced search of clinical, laboratory and pharmacy records from March 2009 to May 2016...
February 7, 2018: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/29390396/acute-keratoconjunctivitis-due-to-contamination-of-contact-lens-care-solution-with-histamine-producing-raoultella-species-a-case-report
#19
Hiroshi Eguchi, Fumika Hotta, Tomomi Kuwahara, Haruyuki Nakayama-Imaohji, Shunji Kusaka, Yoshikazu Shimomura
RATIONALE: Contact lens storage cases are known to be contaminated by a significant number of bacteria. However, histamine-producing Raoultella species has not been reported to contaminate contact lens storage case. PATIENT CONCERNS: A 27-year-old woman with keratoconjunctivitis that developed in the left eye owing to a cosmetic contact lens and poor hygiene was referred to our hospital. The corrected visual acuity was hand motion. DIAGNOSES: Corneal infection other than Acanthamoeba keratitis (AK) and corneal hypoxia were excluded...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29386617/microbial-keratitis-in-corneal-grafts-predisposing-factors-and-outcomes
#20
A C O Okonkwo, W F Siah, H D J Hogg, H Anwar, F C Figueiredo
PurposeTo identify the nature of microbial keratitis in corneal grafts and the clinical outcomes at a tertiary hospital in the United Kingdom.Patients and methodsA retrospective case series of microbial keratitis in corneal grafts at the Royal Victoria Infirmary, Newcastle upon Tyne over a 17-year period (1997-2014).ResultsA total of 759 consecutive corneal grafts were identified from the Cornea Transplantation database. Of these, 59 episodes of microbial keratitis occurred in 41 eyes of 41 patients (5.4%; 19 male, 46...
April 2018: Eye
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