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https://www.readbyqxmd.com/read/28100439/considerations-for-an-access-centered-design-of-the-fever-thermometer-in-low-resource-settings-a-literature-review
#1
REVIEW
Rikako Iwamoto, Ana Laura Rodrigues Santos, Niels Chavannes, Ria Reis, Jan Carel Diehl
BACKGROUND: The lack of adequate information about fever in low-resource settings, its unreliable self-assessment, and poor diagnostic practices may result in delayed care and under-or-overdiagnosis of diseases such as malaria. The mismatches of existing fever thermometers in the context of use imply that the diagnostic tools and connected services need to be studied further to address the challenges of fever-related illnesses and their diagnostics. OBJECTIVE: This study aims to inform a product-service system approach to design a reliable and accessible fever thermometer and connected services, as well as contribute to the identification of innovative opportunities to improve health care in low-resource settings...
January 18, 2017: JMIR Human Factors
https://www.readbyqxmd.com/read/28100237/surveillance-and-response-for-high-risk-populations-what-can-malaria-elimination-programmes-learn-from-the-experience-of-hiv
#2
REVIEW
Jerry O Jacobson, Carmen Cueto, Jennifer L Smith, Jimee Hwang, Roly Gosling, Adam Bennett
To eliminate malaria, malaria programmes need to develop new strategies for surveillance and response appropriate for the changing epidemiology that accompanies transmission decline, in which transmission is increasingly driven by population subgroups whose behaviours place them at increased exposure. Conventional tools of malaria surveillance and response are likely not sufficient in many elimination settings for accessing high-risk population subgroups, such as mobile and migrant populations (MMPs), given their greater likelihood of asymptomatic infections, illegal risk behaviours, limited access to public health facilities, and high mobility including extended periods travelling away from home...
January 18, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28096847/transfusion-transmitted-malaria-in-iran-a-narrative-review-article
#3
REVIEW
Ahmad Mardani, Hossein Keshavarz, Ali Akbar Pourfathollah, Mahtab Maghsudlu
BACKGROUND: Malaria is the most important transfusion-transmitted infection (TTI) in worldwide after viral hepatitis and human immunodeficiency virus (HIV) infection. The main objective of the present study was to review and evaluate the transmission of malaria via blood transfusion in Iran. METHODS: A literature search was done without time limitation in the electronic databases as follows: PubMed, Scopus, Google Scholar, Web of Science, Science Direct, scientific information database (SID), Magiran, IranMedex and Irandoc...
April 2016: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/28093995/glycosides-as-possible-lead-antimalarial-in-new-drug-discovery-future-perspectives
#4
Marya, Haroon Khan, Izhar Ahmad
Malaria remains one of the major public health problems worldwide and is responsible for a large number of morbidity and mortality. Especially, in the third world countries, it is still alarming. The development of drug-resistant to Plasmodium falciparum strains has further degraded the overall situation. However, a limited number of effective drugs available emphasizes how essential it is to establish new anti-malarial compounds. New antimalarial agents with distinctive structures and mechanism of action from the natural origin are thus immediately required to treat sensitive and drug-resistant strains of malaria...
January 15, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28088326/acute-kidney-injury-due-to-tropical-infectious-diseases-and-animal-venoms-a-tale-of-2-continents
#5
REVIEW
Emmanuel A Burdmann, Vivekanand Jha
South and Southeast Asia and Latin American together comprise 46 countries and are home to approximately 40% of the world population. The sociopolitical and economic heterogeneity, tropical climate, and malady transitions characteristic of the region strongly influence disease behavior and health care delivery. Acute kidney injury epidemiology mirrors these inequalities. In addition to hospital-acquired acute kidney injury in tertiary care centers, these countries face a large preventable burden of community-acquired acute kidney injury secondary to tropical infectious diseases or animal venoms, affecting previously healthy young individuals...
January 11, 2017: Kidney International
https://www.readbyqxmd.com/read/28087910/-progress-on-anti-tumor-molecular-mechanisms-of-dihydroartemisinin
#6
Peng Cao, Dongjin Leng, Ying Li, Ziwei Zhang, Lei Liu, Xiaoyan Li
Artemisinin is an anti-malarial drug with poor water solubility and oral absorption; so a variety of derivatives based on the parent nucleus have been developed. Compared with artemisinin, dihydroartemisinin (DHA) has a stronger anti-malaria activity, and has the advantages of high metabolic rate and better water solubility. Recent studies have discovered that DHA has a good inhibitory effect on tumor cells, which is closely related to the peroxide bridge in its molecular structure. Since tumor cells need more Fe(3+) than normal cells, there are a large number of transferrin receptors on the tumor cell membrane...
May 25, 2016: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
https://www.readbyqxmd.com/read/28086874/new-developments-in-anti-malarial-target-candidate-and-product-profiles
#7
REVIEW
Jeremy N Burrows, Stephan Duparc, Winston E Gutteridge, Rob Hooft van Huijsduijnen, Wiweka Kaszubska, Fiona Macintyre, Sébastien Mazzuri, Jörg J Möhrle, Timothy N C Wells
A decade of discovery and development of new anti-malarial medicines has led to a renewed focus on malaria elimination and eradication. Changes in the way new anti-malarial drugs are discovered and developed have led to a dramatic increase in the number and diversity of new molecules presently in pre-clinical and early clinical development. The twin challenges faced can be summarized by multi-drug resistant malaria from the Greater Mekong Sub-region, and the need to provide simplified medicines. This review lists changes in anti-malarial target candidate and target product profiles over the last 4 years...
January 13, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28077167/role-of-anopheles-cellia-rufipes-gough-1910-and-other-local-anophelines-in-human-malaria-transmission-in-the-northern-savannah-of-cameroon-a-cross-sectional-survey
#8
Raymond N Tabue, Parfait Awono-Ambene, Josiane Etang, Jean Atangana, Antonio-Nkondjio C, Jean C Toto, Salomon Patchoke, Rose G F Leke, Etienne Fondjo, Abraham P Mnzava, Tessa B Knox, Alexis Tougordi, Martin J Donnelly, Jude D Bigoga
BACKGROUND: As part of a study to determine the impact of insecticide resistance on the effectiveness of long-lasting insecticide treated nets (LLINs) in the north of Cameroon, the unexpectedly high density and anthropophilic behaviour of Anopheles rufipes lead us to investigate this species bionomics and role in human malaria parasite transmission. METHODS: For four consecutive years (2011-2014), annual cross-sectional sampling of adult mosquitoes was conducted during the peak malaria season (September-October) in three health districts in northern Cameroon...
January 11, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28076467/the-search-for-novel-insecticide-targets-in-the-post-genomics-era-with-a-specific-focus-on-g-protein-coupled-receptors
#9
Michelle Ngai, Mary Ann McDowell
Insects are considered pests globally, implicated in the destruction of agricultural fields and transmission of pathogens that cause deadly human diseases, such as dengue, Zika and malaria. The diversity of the insecticide arsenal has remained stagnant for decades, but the recent rise of insecticide resistance fueled the discovery of novel modes of action, and the power of genomics has reinvigorated this search. This review discusses the importance of comparative and functional insect genomics in the identification of potential gene targets for an insecticidal mode of action with low off-target toxicity...
January 1, 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28075558/immunological-principles-guiding-the-rational-design-of-particles-for-vaccine-delivery
#10
Katelyn T Gause, Adam K Wheatley, Jiwei Cui, Yan Yan, Stephen J Kent, Frank Caruso
Despite the immense public health successes of immunization over the past century, effective vaccines are still lacking for globally important pathogens such as human immunodeficiency virus, malaria, and tuberculosis. Exciting recent advances in immunology and biotechnology over the past few decades have facilitated a shift from empirical to rational vaccine design, opening possibilities for improved vaccines. Some of the most important advancements include (i) the purification of subunit antigens with high safety profiles, (ii) the identification of innate pattern recognition receptors (PRRs) and cognate agonists responsible for inducing immune responses, and (iii) developments in nano- and microparticle fabrication and characterization techniques...
January 11, 2017: ACS Nano
https://www.readbyqxmd.com/read/28073732/insecticide-resistance-in-anopheles-mosquitoes%C3%A2-additional-obstacles-in-the-battle-against-malaria
#11
A Rubert, L Guillon-Grammatico, J Chandenier, I Dimier-Poisson, G Desoubeaux
Mosquitoes of the genus Anopheles are malaria vectors in tropical areas and were of course designated as primary targets by programs for malaria control. Repellent sprays, indoor use of insecticides, and massive delivery of mosquito nets are standard examples of the means widely used to combat malaria. This synthetic review supplies an overview of all of the modes of resistance developed by Anopheles mosquitoes against these human actions. The misuse of each available tool has gradually led to a decrease in its global effectiveness...
November 1, 2016: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/28072872/population-pharmacokinetic-properties-of-piperaquine-in-falciparum-malaria-an-individual-participant-data-meta-analysis
#12
Richard M Hoglund, Lesley Workman, Michael D Edstein, Nguyen Xuan Thanh, Nguyen Ngoc Quang, Issaka Zongo, Jean Bosco Ouedraogo, Steffen Borrmann, Leah Mwai, Christian Nsanzabana, Ric N Price, Prabin Dahal, Nancy C Sambol, Sunil Parikh, Francois Nosten, Elizabeth A Ashley, Aung Pyae Phyo, Khin Maung Lwin, Rose McGready, Nicholas P J Day, Philippe J Guerin, Nicholas J White, Karen I Barnes, Joel Tarning
BACKGROUND: Artemisinin-based combination therapies (ACTs) are the mainstay of the current treatment of uncomplicated Plasmodium falciparum malaria, but ACT resistance is spreading across Southeast Asia. Dihydroartemisinin-piperaquine is one of the five ACTs currently recommended by the World Health Organization. Previous studies suggest that young children (<5 y) with malaria are under-dosed. This study utilised a population-based pharmacokinetic approach to optimise the antimalarial treatment regimen for piperaquine...
January 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28059665/efficacy-of-phase-3-trial-of-rts-s-as01-malaria-vaccine-in-infants-a-systematic-review-and-meta-analysis
#13
Shima Mahmoudi, Hossein Keshavarz
Although vaccines would be the ideal tool for control, prevention, elimination, and eradication of many infectious diseases, developing of parasites vaccines such as malaria vaccine is very complex. The most advanced malaria vaccine candidate is RTS,S, a pre-erythrocytic vaccine for which pivotal phase III trial design is underway. Few recent malaria vaccine review articles have attempted to outline of all clinical trials that have occurred globally and no meta-analysis was performed on efficacy of Phase 3 Trial of RTS, S/AS01 Malaria vaccine up to now in infants...
January 6, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28057165/current-and-future-diagnostic-tests-for-ebola-virus-disease
#14
Bharti Singh, Advaita Ganguly, Hoon H Sunwoo
Ebola virus disease (EVD) is a major public health concern with a high mortality rate in infected individuals. Outbreaks of Ebola have been widespread-there is no rapid, sensitive, specific, and affordable diagnostic test for the virus, nor there is any treatment for the disease. Overlapping symptoms of other endemic diseases, such as malaria and cholera, make it difficult to diagnose EVD. For clinical management, outbreak investigation, and proper surveillance, EVD requires a detection system, which should be fast, sensitive, specific, efficient, affordable, and user-friendly with in-country staff...
October 2016: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28056035/a-systematic-review-of-the-incidence-risk-factors-and-case-fatality-rates-of-invasive-nontyphoidal-salmonella-ints-disease-in-africa-1966-to-2014
#15
Ifeanyi Valentine Uche, Calman A MacLennan, Allan Saul
This study systematically reviews the literature on the occurrence, incidence and case fatality rate (CFR) of invasive nontyphoidal Salmonella (iNTS) disease in Africa from 1966 to 2014. Data on the burden of iNTS disease in Africa are sparse and generally have not been aggregated, making it difficult to describe the epidemiology that is needed to inform the development and implementation of effective prevention and control policies. This study involved a comprehensive search of PubMed and Embase databases...
January 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28049486/towards-eliminating-malaria-in-high-endemic-countries-the-roles-of-community-health-workers-and-related-cadres-and-their-challenges-in-integrated-community-case-management-for-malaria-a-systematic-review
#16
REVIEW
Bruno F Sunguya, Linda B Mlunde, Rakesh Ayer, Masamine Jimba
BACKGROUND: Human resource for health crisis has impaired global efforts against malaria in highly endemic countries. To address this, the World Health Organization (WHO) recommended scaling-up of community health workers (CHWs) and related cadres owing to their documented success in malaria and other disease prevention and management. Evidence is inconsistent on the roles and challenges they encounter in malaria interventions. This systematic review aims to summarize evidence on roles and challenges of CHWs and related cadres in integrated community case management for malaria (iCCM)...
January 3, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28049347/strategies-to-enhance-biologically-active-secondary-metabolites-in-cell-cultures-of-artemisia-current-trends
#17
Mohammad Ali, Bilal Haider Abbasi, Nisar Ahmad, Haji Khan, Gul Shad Ali
The genus Artemisia has been utilized worldwide due to its immense potential for protection against various diseases, especially malaria. Artemisia absinthium, previously renowned for its utilization in the popular beverage absinthe, is gaining resurgence due to its extensive pharmacological activities. Like A. annua, this species exhibits strong biological activities like antimalarial, anticancer and antioxidant. Although artemisinin was found to be the major metabolite for its antimalarial effects, several flavonoids and terpenoids are considered to possess biological activities when used alone and also to synergistically boost the bioavailability of artemisinin...
January 3, 2017: Critical Reviews in Biotechnology
https://www.readbyqxmd.com/read/28044045/recrudescence-of-plasmodium-falciparum-in-a-primigravida-after-nearly-3-years-of-latency
#18
Ahmed Al Hammadi, Michael Mitchell, George M Abraham, Jennifer P Wang
We present a case of a primigravid woman who presented with Plasmodium falciparum nearly 3 years after she last visited a malaria-endemic region. We review the literature to identify case reports of recrudescent P falciparum malaria during pregnancy, including those with prolonged latency. Reports of recrudescence of P falciparum during pregnancy are limited. Plasmodium falciparum infection can persist for years. Recrudescence can occur with waning of immunity following departure from endemic areas. Pregnancy, particularly the primigravid state, is a risk factor for severe infection...
January 2, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28043178/towards-clinical-development-of-a-pfs48-45-based-transmission-blocking-malaria-vaccine
#19
Michael Theisen, Matthijs M Jore, Robert Sauerwein
Malaria is a devastating vector-borne disease caused by the Plasmodium parasite, resulting in almost 0.5 million casualties per year. The parasite has a complex life-cycle that includes asexual replication in human red blood cells, causing symptomatic malaria, and sexual stages which are essential for the transmission to the mosquito vector. A vaccine targeting the sexual stages of the parasite and thus blocking transmission will be instrumental for the eradication of malaria. One of the leading transmission blocking vaccine candidates is the sexual stage antigen Pfs48/45...
January 3, 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/28042865/the-role-of-natural-products-in-drug-discovery-and-development-against-neglected-tropical-diseases
#20
REVIEW
Peter Mubanga Cheuka, Godfrey Mayoka, Peggoty Mutai, Kelly Chibale
Endemic in 149 tropical and subtropical countries, neglected tropical diseases (NTDs) affect more than 1 billion people annually, including 875 million children in developing economies. These diseases are also responsible for over 500,000 deaths per year and are characterized by long-term disability and severe pain. The impact of the combined NTDs closely rivals that of malaria and tuberculosis. Current treatment options are associated with various limitations including widespread drug resistance, severe adverse effects, lengthy treatment duration, unfavorable toxicity profiles, and complicated drug administration procedures...
December 31, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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