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https://www.readbyqxmd.com/read/28319831/structure-based-prediction-of-host-pathogen-protein-interactions
#1
REVIEW
Rachelle Mariano, Stefan Wuchty
The discovery, validation, and characterization of protein-based interactions from different species are crucial for translational research regarding a variety of pathogens, ranging from the malaria parasite Plasmodium falciparum to HIV-1. Here, we review recent advances in the prediction of host-pathogen protein interfaces using structural information. In particular, we observe that current methods chiefly perform machine learning on sequence and domain information to produce large sets of candidate interactions that are further assessed and pruned to generate final, highly probable sets...
March 16, 2017: Current Opinion in Structural Biology
https://www.readbyqxmd.com/read/28306665/molecular-mechanisms-that-mediate-invasion-and-egress-of-malaria-parasites-from-red-blood-cells
#2
Aditi Alaganan, Pallavi Singh, Chetan E Chitnis
PURPOSE OF REVIEW: Malaria parasites invade and multiply in diverse host cells during their complex life cycle. Some blood stage parasites transform into male and female gametocytes that are transmitted by female anopheline mosquitoes. The gametocytes are activated in the mosquito midgut to form male and female gametes, which egress from RBCs to mate and form a zygote. Here, we will review our current understanding of the molecular mechanisms that mediate invasion and egress by malaria parasites at different life cycle stages...
March 16, 2017: Current Opinion in Hematology
https://www.readbyqxmd.com/read/28302941/organochlorine-pesticide-contamination-of-foods-in-africa-incidence-and-public-health-significance
#3
Lesa A Thompson, Wageh Sobhy Darwish, Yoshinori Ikenaka, Shouta M M Nakayama, Hazuki Mizukawa, Mayumi Ishizuka
Organochlorine pesticides (OCPs) have been used worldwide, particularly in Africa for several decades. Although many are banned, several African countries still use OCPs especially for the prevention and control of malaria. OCPs are characterized by their bio-accumulation in the environment, especially in the food chain, where they find their way into the human body. Despite no clear epidemiological studies confirming hazardous effects of these chemicals on human health, many studies have reported positive associations between the use of OCPs and neurological and reproductive disorders, and cancer risk...
March 16, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28295179/platelets-and-infections-in-the-resource-limited-countries-with-a-focus-on-malaria-and-viral-haemorrhagic-fevers
#4
REVIEW
Jecko Thachil
Infections continue to cause a high incidence of mortality and morbidity in resource-poor nations. Although antimicrobial therapy has aided mostly in dealing with the pathogenic micro-organisms themselves, the collateral damage caused by the infections continue to cause many deaths. Intensive care support and manipulation of the hosts' abnormal response to the infection have helped to improve mortality in well-resourced countries. But, in those areas with limited resources, this is not yet the case and simpler methods of diagnosis and interventions are required...
March 14, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28293406/%C3%AE-thalassemia-distribution-in-the-old-world-an-ancient-disease-seen-from-a-historical-standpoint
#5
REVIEW
Vincenzo De Sanctis, Christos Kattamis, Duran Canatan, Ashraf T Soliman, Heba Elsedfy, Mehran Karimi, Shahina Daar, Yasser Wali, Mohamed Yassin, Nada Soliman, Praveen Sobti, Soad Al Jaouni, Mohamed El Kholy, Bernadette Fiscina, Michael Angastiniotis
BACKGROUND: Haemoglobinopathies constitute the commonest recessive monogenic disorders worldwide, and the treatment of affected individuals presents a substantial global disease burden. β-thalassaemia is characterised by the reduced synthesis (β(+)) or absence (β(o)) of the β-globin chains in the HbA molecule, resulting in accumulation of excess unbound α-globin chains that precipitate in erythroid precursors in the bone marrow and in the mature erythrocytes, leading to ineffective erythropoiesis and peripheral haemolysis...
2017: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/28291967/phototoxicity-of-doxycycline-a-systematic-review-on-clinical-manifestations-frequency-cofactors-and-prevention
#6
Steven Goetze, Christian Hiernickel, Peter Elsner
BACKGROUND: One of the most important dermatologic side effects of doxycycline is photosensitivity. As doxycycline is important for malaria prophylaxis and malaria is mainly spread in countries with high sun radiation, special attention should be paid to this adverse effect. While there are many publications on the phototoxicity of tetracyclines in general, only a few exist focusing on doxycycline. The objective of this systematic review was to summarize all available reports on clinical manifestations, influencing factors like UV dose or dose of medication, and the possibilities of prevention by sun protection...
March 15, 2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/28290995/uses-of-polypills-for-cardiovascular-disease-and-evidence-to-date
#7
REVIEW
Mark D Huffman, Denis Xavier, Pablo Perel
Polypills have been approved in more than 30 countries, but worldwide experience with and availability of polypills remain limited, unlike fixed-dose combinations in other diseases such as HIV, tuberculosis, and malaria. In this Series review, we aim to propose a guide for the use of polypills in future research and clinical activities and to synthesise contemporary evidence supporting the use of polypills for prevention of atherosclerosis. Polypill uses can be categorised by population and indication, both of which influence the balance between benefits and risks...
March 11, 2017: Lancet
https://www.readbyqxmd.com/read/28284211/a-systematic-review-of-the-clinical-presentation-treatment-and-relapse-characteristics-of-human-plasmodium-ovale-malaria
#8
REVIEW
Mirjam Groger, Hannah S Fischer, Luzia Veletzky, Albert Lalremruata, Michael Ramharter
BACKGROUND: Despite increased efforts to control and ultimately eradicate human malaria, Plasmodium ovale malaria is for the most part outside the focus of research or public health programmes. Importantly, the understanding of P. ovale-nowadays regarded as the two distinct species P. ovale wallikeri and P. ovale curtisi-largely stems from case reports and case series lacking study designs providing high quality evidence. Consecutively, there is a lack of systematic evaluation of the clinical presentation, appropriate treatment and relapse characteristics of P...
March 11, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28276701/genomics-of-apicomplexan-parasites
#9
Lakshmipuram Seshadri Swapna, John Parkinson
The increasing prevalence of infections involving intracellular apicomplexan parasites such as Plasmodium, Toxoplasma, and Cryptosporidium (the causative agents of malaria, toxoplasmosis, and cryptosporidiosis, respectively) represent a significant global healthcare burden. Despite their significance, few treatments are available; a situation that is likely to deteriorate with the emergence of new resistant strains of parasites. To lay the foundation for programs of drug discovery and vaccine development, genome sequences for many of these organisms have been generated, together with large-scale expression and proteomic datasets...
February 22, 2017: Critical Reviews in Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28272734/safety-and-benefits-of-antenatal-oral-iron-supplementation-in-low-income-countries-a-review
#10
REVIEW
Martin N Mwangi, Andrew M Prentice, Hans Verhoef
The World Health Organization recommends universal iron supplementation of 30-60 mg/day in pregnancy but coverage is low in most countries. Its efficacy is uncertain, however, and there has been a vigorous debate in the last decade about its safety, particularly in areas with a high burden of malaria and other infectious diseases. We reviewed the evidence on the safety and efficacy of antenatal iron supplementation in low-income countries. We found no evidence that daily supplementation at a dose of 60 mg leads to increased maternal Plasmodium infection risk...
March 8, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28270257/new-developments-in-probing-and-targeting-protein-acylation-in-malaria-leishmaniasis-and-african-sleeping-sickness
#11
Markus Ritzefeld, Megan H Wright, Edward W Tate
Infections by protozoan parasites, such as Plasmodium falciparum or Leishmania donovani, have a significant health, social and economic impact and threaten billions of people living in tropical and sub-tropical regions of developing countries worldwide. The increasing range of parasite strains resistant to frontline therapeutics makes the identification of novel drug targets and the development of corresponding inhibitors vital. Post-translational modifications (PTMs) are important modulators of biology and inhibition of protein lipidation has emerged as a promising therapeutic strategy for treatment of parasitic diseases...
March 8, 2017: Parasitology
https://www.readbyqxmd.com/read/28270154/pandemics-pathogenicity-and-changing-molecular-epidemiology-of-cholera-in-the-era-of-global-warming
#12
REVIEW
Fazle Rabbi Chowdhury, Zannatun Nur, Nazia Hassan, Lorenz von Seidlein, Susanna Dunachie
BACKGROUND: Vibrio cholerae, a Gram-negative, non-spore forming curved rod is found in diverse aquatic ecosystems around the planet. It is classified according to its major surface antigen into around 206 serogroups, of which O1 and O139 cause epidemic cholera. A recent spatial modelling technique estimated that around 2.86 million cholera cases occur globally every year, and of them approximately 95,000 die. About 1.3 billion people are currently at risk of infection from cholera. Meta-analysis and mathematical modelling have demonstrated that due to global warming the burden of vector-borne diseases like malaria, leishmaniasis, meningococcal meningitis, viral encephalitis, dengue and chikungunya will increase in the coming years in the tropics and beyond...
March 7, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/28270152/a-systematic-review-on-malaria-sero-epidemiology-studies-in-the-brazilian-amazon-insights-into-immunological-markers-for-exposure-and-protection
#13
Pedro M Folegatti, André M Siqueira, Wuelton M Monteiro, Marcus Vinícius G Lacerda, Chris J Drakeley, Érika M Braga
BACKGROUND: Considerable success in reducing malaria incidence and mortality has been achieved in Brazil, leading to discussions over the possibility of moving towards elimination. However, more than reporting and counting clinical cases, elimination will require the use of efficient tools and strategies for measuring transmission dynamics and detecting the infectious reservoir as the primary indicators of interest for surveillance and evaluation. Because acquisition and maintenance of anti-malarial antibodies depend on parasite exposure, seroprevalence rates could be used as a reliable tool for assessing malaria endemicity and an adjunct measure for monitoring transmission in a rapid and cost-effective manner...
March 7, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28259160/in-vivo-efficacy-of-top-five-surveyed-ghanaian-herbal-anti-malarial-products
#14
Dennis Wilmot, Elvis Ofori Ameyaw, Daniel Amoako-Sakyi, Johnson Nyarko Boampong, Neils Ben Quashie
BACKGROUND: Anti-malarial herbal preparations (HPs) continue to enjoy high patronage in Ghana despite reports that the artemisinin-based combination therapy (ACT), the recommended first choice for treatment of uncomplicated malaria in the country, remains efficacious. A major issue with the use of these preparations is inadequate or unreliable data on their efficacy and quality. An assessment of the potency and quality of the most popular commercial anti-malarial HPs in Ghana was, therefore, carried out...
March 4, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28258239/the-pushmi-pullyu-of-resistance-to-chloroquine-in-malaria
#15
REVIEW
Ruth Skrzypek, Richard Callaghan
Malarial infection continues to impart devastating health problems in the developing world. Treatment of malaria has involved chemotherapy since 168 BC, with the most prevalent and successful forms using plant alkaloids. Perhaps the greatest treatment success against malaria was by chloroquine, a synthetic derivative of the quinines found in the Cinchona tree bark. Chloroquine is able to kill parasites by interfering with haem metabolism in the parasite's digestive vacuole. The widespread use of chloroquine predictably resulted in the development of drug-resistant malaria and the most highly implicated resistance mediators are the transporter proteins P-glycoprotein (P-gp) homologue 1 (P-gh1) and Plasmodium falciparum chloroquine-resistance transporter (PfCRT), which reside on the parasite's digestive vacuole...
February 28, 2017: Essays in Biochemistry
https://www.readbyqxmd.com/read/28256926/-when-i-am-with-my-husband-i-do-not-feel-mosquito-bite
#16
Mary Anita Quist, Augustine Adomah-Afari
Purpose The purpose of this paper is to explore how socio-cultural beliefs and practices could influence the knowledge, attitude and perception of insecticide-treated net (ITN) use in the control of malaria amongst pregnant women attending antenatal clinic. Design/methodology/approach Data were gathered using interviews and documentary review. Framework analysis was applied to classify emerging themes and the findings interpreted using the health belief model. Findings The findings showed that the pregnant women had appreciable knowledge, both the positive and negative attitudes and the perceptions of insecticide treated nets...
March 13, 2017: International Journal of Health Care Quality Assurance
https://www.readbyqxmd.com/read/28255648/short-term-effects-of-fine-particulate-matter-pollution-on-daily-health-events-in-latin-america-a-systematic-review-and-meta-analysis
#17
REVIEW
Laís Fajersztajn, Paulo Saldiva, Luiz Alberto Amador Pereira, Victor Figueiredo Leite, Anna Maria Buehler
OBJECTIVES: Ambient air pollution is among the leading risks for health worldwide and by 2050 will largely overcome deaths due to unsafe sanitation and malaria, but local evidence from Latin America (LA) is scarce. We aimed to summarize the effect of short-term exposure to fine particulate air pollution (PM2.5) on morbidity and mortality in Latin America and evaluate evidence coverage and quality, using systematic review and meta-analysis. METHODS: The comprehensive search (six online databases and hand-searching) identified studies investigating the short-term associations between PM2...
March 2, 2017: International Journal of Public Health
https://www.readbyqxmd.com/read/28254675/from-ancient-herb-to-modern-drug-artemisia-annua-and-artemisinin-for-cancer-therapy
#18
REVIEW
Thomas Efferth
Artemisia annua L. is used throughout Asia and Africa as tea and press juice to treat malaria and related symptomes (fever, chills). Its active ingredient, artemisinin (ARS), has been developed as antimalarial drug and is used worldwide. Interestingly, the bioactivity is not restricted to malaria treatment. We and others found that ARS-type drugs also reveal anticancer in vitro and in vivo. In this review, we give a systematic overview of the literature published over the past two decades until the end of 2016...
February 28, 2017: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/28253926/exo-erythrocytic-development-of-avian-malaria-and-related-haemosporidian-parasites
#19
REVIEW
Gediminas Valkiūnas, Tatjana A Iezhova
BACKGROUND: Avian malaria parasites (Plasmodium spp.) and related haemosporidians (Haemosporida) are responsible for diseases which can be severe and even lethal in avian hosts. These parasites cause not only blood pathology, but also damage various organs due to extensive exo-erythrocytic development all over the body, which is not the case during Plasmodium infections in mammals. However, exo-erythrocytic development (tissue merogony or schizogony) remains the most poorly investigated part of life cycle in all groups of wildlife haemosporidian parasites...
March 3, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28253315/introducing-malaria-rapid-diagnostic-tests-in-private-medicine-retail-outlets-a-systematic-literature-review
#20
Theodoor Visser, Katia Bruxvoort, Kathleen Maloney, Toby Leslie, Lawrence M Barat, Richard Allan, Evelyn K Ansah, Jennifer Anyanti, Ian Boulton, Siân E Clarke, Jessica L Cohen, Justin M Cohen, Andrea Cutherell, Caitlin Dolkart, Katie Eves, Günther Fink, Catherine Goodman, Eleanor Hutchinson, Sham Lal, Anthony Mbonye, Obinna Onwujekwe, Nora Petty, Julie Pontarollo, Stephen Poyer, David Schellenberg, Elizabeth Streat, Abigail Ward, Virginia Wiseman, Christopher J M Whitty, Shunmay Yeung, Jane Cunningham, Clare I R Chandler
BACKGROUND: Many patients with malaria-like symptoms seek treatment in private medicine retail outlets (PMR) that distribute malaria medicines but do not traditionally provide diagnostic services, potentially leading to overtreatment with antimalarial drugs. To achieve universal access to prompt parasite-based diagnosis, many malaria-endemic countries are considering scaling up malaria rapid diagnostic tests (RDTs) in these outlets, an intervention that may require legislative changes and major investments in supporting programs and infrastructures...
2017: PloS One
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