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https://www.readbyqxmd.com/read/29330676/quantitative-outcomes-of-a-one-health-approach-to-study-global-health-challenges
#1
REVIEW
Laura C Falzon, Isabel Lechner, Ilias Chantziaras, Lucie Collineau, Aurélie Courcoul, Maria-Eleni Filippitzi, Riikka Laukkanen-Ninios, Carole Peroz, Jorge Pinto Ferreira, Merel Postma, Pia G Prestmo, Clare J Phythian, Eleonora Sarno, Gerty Vanantwerpen, Timothée Vergne, Douglas J C Grindlay, Marnie L Brennan
Having gained momentum in the last decade, the One Health initiative promotes a holistic approach to address complex global health issues. Before recommending its adoption to stakeholders, however, it is paramount to first compile quantitative evidence of the benefit of such an approach. The aim of this scoping review was to identify and summarize primary research that describes monetary and non-monetary outcomes following adoption of a One Health approach. An extensive literature search yielded a total of 42,167 references, of which 85 were included in the final analysis...
January 12, 2018: EcoHealth
https://www.readbyqxmd.com/read/29313573/p-vivax-malaria-presenting-as-thrombotic-microangiopathy
#2
Dharmendra Bhadauria, Harsh Vardhan, Anupma Kaul, Raj Kumar Sharma, Amit Gupta, Narayan Prasad, Manoj Jain
Introduction: Acute kidney injury (AKI) is reported to occur in patients with falciparum malaria but not uncommon with vivax malaria. AKI, anemia, thrombocytopenia and jaundice is a recurrent finding in severe malaria and can mimic as thrombotic microangiopathy (TMA). Relationship of malaria with TMA is unclear till date however evidences suggest their association. Methods & Material: We reviewed our electronic database to evaluate relationship of malaria with TMA, of cases of malaria, jaundice and AKI...
September 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/29310704/mapping-insecticide-resistance-in-anopheles-gambiae-s-l-from-c%C3%A3-te-d-ivoire
#3
Soromane Camara, Alphonsine A Koffi, Ludovic P Ahoua Alou, Kouakou Koffi, Jean-Paul K Kabran, Aboubacar Koné, Mathieu F Koffi, Raphaël N'Guessan, Cédric Pennetier
BACKGROUND: Insecticide resistance in malaria vectors is an increasing threat to vector control tools currently deployed in endemic countries. Resistance management must be an integral part of National Malaria Control Programmes' (NMCPs) next strategic plans to alleviate the risk of control failure. This obviously will require a clear database on insecticide resistance to support the development of such a plan. The present work gathers original data on insecticide resistance between 2009 and 2015 across Côte d'Ivoire in West Africa...
January 8, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29309574/the-role-of-the-technical-review-panel-of-the-global-fund-to-fight-hiv-aids-tuberculosis-and-malaria-an-analysis-of-grant-recommendations
#4
Guido Schmidt-Traub
The independent Technical Review Panel (TRP) of the Global Fund to Fight HIV/AIDS, Tuberculosis and Malaria is a unique mechanism to review funding proposals and to provide recommendations on their funding. Its functioning and performance have received little attention in the scientific literature. We aimed to identify predictors for TRP recommendations, whether these were in line with the Global Fund's ambition to give priority to countries most in need, and whether they correlated with grant performance. We combined data on proposals and applications under the Rolling Continuation Channel, TRP recommendations and grant implementation during the rounds-based mechanism (2002-2010) with country characteristics...
January 4, 2018: Health Policy and Planning
https://www.readbyqxmd.com/read/29307707/travel-related-infections-among-pregnant-travellers-to-the-tropics-an-overview
#5
Ling Yuan Kong, Michael D Libman, Cedric P Yansouni
Infectious diseases acquired during travel pose a significant health risk to pregnant travellers, who are more susceptible to both acquiring certain infections and developing severe complications. A review of the literature focusing on recent evidence-based guidelines was conducted with attention to tropical infections in the pregnant patient. A summary meant to serve as a succinct reference for health care professionals caring for pregnant women is presented. Magnitude of risk, clinical features, management, and preventive strategies of major travel-acquired infections of pertinence to the pregnant traveller are summarized, including malaria, arboviral infections, foodborne infections, helminthic infections, and influenza...
January 4, 2018: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/29301722/human-interventions-driving-forces-of-mosquito-evolution
#6
REVIEW
Caroline Fouet, Peter Atkinson, Colince Kamdem
One of the most common strategies for controlling mosquito-borne diseases relies on the use of chemical pesticides to repel or kill the mosquito vector. Pesticide exposure interferes with several key biological functions in the mosquito and triggers a variety of adaptive responses whose underlying mechanisms are only partially elucidated. The availability of reference genome sequences opens up the possibility of tracking signatures of evolutionary changes, including the most recent, across the genomes of many vector species...
November 29, 2017: Trends in Parasitology
https://www.readbyqxmd.com/read/29301383/increasing-the-strength-and-production-of-artemisinin-and-its-derivatives
#7
REVIEW
Syed Lal Badshah, Asad Ullah, Nasir Ahmad, Zainab M Almarhoon, Yahia Mabkhot
Artemisinin is a natural sesquiterpene lactone obtained from the Artemisia annua herb. It is widely used for the treatment of malaria. In this article, we have reviewed the role of artemisinin in controlling malaria, spread of resistance to artemisinin and the different methods used for its large scale production. The highest amount of artemisinin gene expression in tobacco leaf chloroplast leads to the production of 0.8 mg/g of the dry weight of the plant. This will revolutionize the treatment and control of malaria in third world countries...
January 3, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29298303/-every-day-they-keep-adding-new-tools-but-they-don-t-take-any-away-producing-indicators-for-intermittent-preventive-treatment-for-malaria-in-pregnancy-iptp-from-routine-data-in-kenya
#8
George Okello, Rene Gerrets, Scholastica Zakayo, Sassy Molyneux, Caroline Jones
BACKGROUND: Intermittent preventive treatment for malaria in pregnancy (IPTp) is part of a multi-pronged strategy aimed at preventing malaria in pregnancy in areas of moderate to high transmission in sub-Saharan Africa. Despite being formally adopted as a malaria prevention policy over a decade ago, IPTp coverage has remained low. Recent demands for action have incorporated calls to strengthen IPTp monitoring and evaluation systems, including the use of routine data, to measure coverage, track implementation and identify roadblocks to improving uptake...
2018: PloS One
https://www.readbyqxmd.com/read/29287981/exploiting-the-apicoplast-apicoplast-targeting-drugs-and-malaria-vaccine-development
#9
Leanne M Low, Danielle I Stanisic, Michael F Good
The apicoplast, a relic plastid found in most Apicomplexan parasites, is a notable drug target. Certain antibiotics elicit a delayed death phenotype by targeting this organelle. Here, we review apicoplast targeting drugs and their targets, particularly those that cause delayed death, and highlight its potential uses in malaria vaccine development.
December 26, 2017: Microbes and Infection
https://www.readbyqxmd.com/read/29284476/why-some-sites-are-responding-better-to-anti-malarial-interventions-a-case-study-from-western-kenya
#10
Anthony Kapesa, Eliningaya J Kweka, Harrysone Atieli, Erasmus Kamugisha, Guofa Zhou, Andrew K Githeko, Guiyun Yan
BACKGROUND: In sub-Saharan Africa, malaria interventions over the last decades have been successful in reducing both mortality and morbidity. In western Kenya however some areas experience contrasting outcomes of the ongoing interventions while the causes for this observation remains not yet clearly known. METHODS: The WHO insecticide (deltamethrin) susceptibility test of the common malaria vectors was studied. Multiple surveys on household use and hospital prescriptions of antimalarial drugs from 2003 to 2015 were done...
December 29, 2017: Malaria Journal
https://www.readbyqxmd.com/read/29284196/genome-wide-survey-and-phylogenetic-analysis-of-histone-acetyltransferases-and-histone-deacetylases-of-plasmodium-falciparum
#11
REVIEW
Abhishek Kanyal, Mukul Rawat, Pratima Gurung, Deepak Choubey, Krishanpal Anamika, Krishanpal Karmodiya
Malaria parasites can readily sense and adapt to environmental changes, thus making the control and eradication of this disease difficult. Molecular studies have unraveled a very tightly coordinated transcriptional machinery governed by complex regulatory mechanisms including chromatin modification and spatiotemporal compartmentalization. Histone modifying enzymes play key roles in the regulation of chromatin modification and gene expression, which are associated with cell cycle progression, antigenic variation and immune evasion...
December 28, 2017: FEBS Journal
https://www.readbyqxmd.com/read/29283063/antiplatelet-potential-of-plant-derived-glycosides-as-possible-lead-compounds
#12
Haroon Khan, Aini Pervaiz, Mohammad A Kamal, Seema Patel
Blood platelets are crucial for maintaining hemostasis and several events in the wound-healing. However, platelet up-regulation leads to the development and the complications of several cardiovascular diseases. For the effective management of these complications, several synthetic drugs are in clinical practice such as aspirin and warfarin. since a long time. But some adverse reactions like aspirin resistance and bleed disorders cause patient in compliance and reduce their therapeutic potential. Thus, the search for potent and safer antiplatelet agents is of great interest...
December 27, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/29282155/choreoathetosis-an-unusual-adverse-effect-of-dihydroartemisinin-piperaquine-a-case-report
#13
Benjamin Momo Kadia, Christian Morfaw, Armelle Corrine Gounoue Simo
BACKGROUND: Dihydroartemisinin-piperaquine is a combination of dihydroartemisinin and piperaquine which is highly effective in the treatment of uncomplicated falciparum malaria. Its adverse effects are generally tolerable and temporary. Choreoathetosis, an involuntary movement disorder characterized by continuous irregular twisting of the body, is not a documented adverse effect of this medication. CASE PRESENTATION: A 41-year-old Cameroonian man of black African ethnicity was brought to our primary care hospital because over the previous 6 hours he had been experiencing involuntary twisting movements of his body and he no longer had control of his limbs...
December 28, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29273442/pharmaceutical-interactions-between-antiretroviral-and-antimalarial-drugs-used-in-chemoprophylaxis
#14
REVIEW
Andreas Erich Zautner, Ottmar Herchenröder, Awatef El Moussi, Norbert Georg Schwarz, Dorothea Franziska Wiemer, Uwe Groß, Hagen Frickmann
Human immunodeficiency virus (HIV) is the causative agent of the Acquired Immunodeficiency Syndrome (AIDS). The pandemic is believed to have originated within the Northern Congo basin covering large parts of the Democratic Republic of Congo, the Republic of Congo, the Central African Republic, Cameroon and Gabon. Although over decades, HIV-1 has spread throughout the World leaving no country unaffected, sub-Saharan Africa remains the region with more than 80% of all infected individuals. The HIV-2 epidemic has largely remained restricted to West Africa along the Upper Guinean forests...
December 19, 2017: Acta Tropica
https://www.readbyqxmd.com/read/29273053/are-respiratory-complications-of-plasmodium-vivax-malaria-an-underestimated-problem
#15
Fernando Val, Sara Avalos, André Alexandre Gomes, José Evelio Albornoz Zerpa, Gustavo Fontecha, André Machado Siqueira, Quique Bassat, Maria Graças Costa Alecrim, Wuelton Marcelo Monteiro, Marcus Vinícius Guimarães Lacerda
BACKGROUND: Respiratory complications are uncommon, but often life-threatening features of Plasmodium vivax malaria. This study aimed to estimate the prevalence and lethality associated with such complications among P. vivax malaria patients in a tertiary hospital in the Western Brazilian Amazon, and to identify variables associated with severe respiratory complications, intensive care need and death. Medical records from 2009 to 2016 were reviewed aiming to identify all patients diagnosed with P...
December 22, 2017: Malaria Journal
https://www.readbyqxmd.com/read/29259767/the-protective-effectiveness-of-control-interventions-for-malaria-prevention-a-systematic-review-of-the-literature
#16
Thomas Kesteman, Milijaona Randrianarivelojosia, Christophe Rogier
Background: Thanks to a considerable increase in funding, malaria control interventions (MCI) whose efficacy had been demonstrated by controlled trials have been largely scaled up during the last decade. Nevertheless, it was not systematically investigated whether this efficacy had been preserved once deployed on the field. Therefore, we sought the literature to assess the disparities between efficacy and effectiveness and the effort to measure the protective effectiveness (PE) of MCI. Methods: The PubMed database was searched for references with keywords related to malaria, to control interventions for prevention and to study designs that allow for the measure of the PE against parasitemia or against clinical outcomes...
2017: F1000Research
https://www.readbyqxmd.com/read/29249333/beyond-hemoglobin-screening-for-malaria-host-factors
#17
REVIEW
Elizabeth S Egan
Severe malaria is caused by the Apicomplexan parasite Plasmodium falciparum, and results in significant global morbidity and mortality, particularly among young children and pregnant women. P. falciparum exclusively infects human erythrocytes during clinical illness, and several natural erythrocyte polymorphisms are protective against severe malaria. Since erythrocytes are enucleated and lack DNA, genetic approaches to understand erythrocyte determinants of malaria infection have historically been limited. This review highlights recent advances in the use of hematopoietic stem cells to facilitate genetic screening for malaria host factors...
December 14, 2017: Trends in Genetics: TIG
https://www.readbyqxmd.com/read/29248635/immunological-bases-of-increased-susceptibility-to-invasive-nontyphoidal-salmonella-infection-in-children-with-malaria-and-anaemia
#18
Tonney S Nyirenda, Wilson L Mandala, Melita A Gordon, Piero Mastroeni
Malaria and anaemia are key underlying factors for iNTS disease in African children. Knowledge of clinical and epidemiological risk-factors for iNTS disease has not been paralleled by an in-depth knowledge of the immunobiology of the disease. Herein, we review human and animal studies on mechanisms of increased susceptibility to iNTS in children.
December 14, 2017: Microbes and Infection
https://www.readbyqxmd.com/read/29243579/recent-development-of-coumarin-derivatives-as-potential-antiplasmodial-and-antimalarial-agents
#19
Xin-Liang Hu, Chuan Gao, Zhi Xu, Ming-Liang Liu, Lian-Shun Feng, Guang-De Zhang
Malaria still remains one of the leading deadliest diseases throughout the world, leading to around 1 million deaths annually. The emergence and spread of growing resistance to the first-line antimalarials, alarming the serious problem in malaria control and demanding the need for new drugs more potent than earlier with improved absorption, distribution, metabolism, and excretion (ADME) profiles. Coumarins, which exhibited various biological properties, also displayed potential in vitro antiplasmodial and in vivo antimalarial activities...
December 14, 2017: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/29242831/novel-concepts-for-hiv-vaccine-vector-design
#20
REVIEW
Quazim A Alayo, Nicholas M Provine, Pablo Penaloza-MacMaster
The unprecedented challenges of developing effective vaccines against intracellular pathogens such as HIV, malaria, and tuberculosis have resulted in more rational approaches to vaccine development. Apart from the recent advances in the design and selection of improved epitopes and adjuvants, there are also ongoing efforts to optimize delivery platforms. Viral vectors are the best-characterized delivery tools because of their intrinsic adjuvant capability, unique cellular tropism, and ability to trigger robust adaptive immune responses...
November 2017: MSphere
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