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Dengue review

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https://www.readbyqxmd.com/read/29777926/epidemiology-of-acute-febrile-illness-in-latin-america
#1
REVIEW
José Moreira, Clarisse S Bressan, Patricia Brasil, Andre M Siqueira
BACKGROUND: The causes of acute febrile illness (AFI) in Latin America (LA) are diverse and its complexity increase as the proportion of fever due to malaria decreases as control and new pathogens emerge in the region. In this context, it is important to shed light over the gaps on the epidemiological characteristics and the geographic range for many AFI aetiologies. AIMS: To review studies on community-acquired fever etiology other than malaria in LA, and to highlight knowledge gaps and challenges needing further investigation...
May 16, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29777177/controlling-vector-borne-diseases-by-releasing-modified-mosquitoes
#2
REVIEW
Heather A Flores, Scott L O'Neill
Aedes mosquito-transmitted diseases, such as dengue, Zika and chikungunya, are becoming major global health emergencies while old threats, such as yellow fever, are re-emerging. Traditional control methods, which have focused on reducing mosquito populations through the application of insecticides or preventing breeding through removal of larval habitat, are largely ineffective, as evidenced by the increasing global disease burden. Here, we review novel mosquito population reduction and population modification approaches with a focus on control methods based on the release of mosquitoes, including the release of Wolbachia-infected mosquitoes and strategies to genetically modify the vector, that are currently under development and have the potential to contribute to a reversal of the current alarming disease trends...
May 18, 2018: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/29761622/host-heme-oxygenase-1-friend-or-foe-in-tackling-pathogens
#3
REVIEW
Nisha Singh, Zeeshan Ahmad, Navin Baid, Ashwani Kumar
Infectious diseases are a major challenge in management of human health worldwide. Recent literature suggests that host immune system could be modulated to ameliorate the pathogenesis of infectious disease. Heme oxygenase (HMOX1) is a key regulator of cellular signaling and it could be modulated using pharmacological reagents. HMOX1 is a cytoprotective enzyme that degrades heme to generate carbon monoxide (CO), biliverdin, and molecular iron. CO and biliverdin (or bilirubin derived from it) can restrict the growth of a few pathogens...
May 14, 2018: IUBMB Life
https://www.readbyqxmd.com/read/29761104/platelets-in-immune-response-to-virus-and-immunopathology-of-viral-infections
#4
REVIEW
Eugenio D Hottz, Fernando A Bozza, Patrícia T Bozza
Platelets are essential effector cells in hemostasis. Aside from their role in coagulation, platelets are now recognized as major inflammatory cells with key roles in the innate and adaptive arms of the immune system. Activated platelets have key thromboinflammatory functions linking coagulation to immune responses in various infections, including in response to virus. Recent studies have revealed that platelets exhibit several pattern recognition receptors (PRR) including those from the toll-like receptor, NOD-like receptor, and C-type lectin receptor family and are first-line sentinels in detecting and responding to pathogens in the vasculature...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29759074/dengue-fever-complicated-with-guillain-barr%C3%A3-syndrome-a-case-report-and-review-of-the-literature
#5
Chamara Dalugama, John Shelton, Mahendra Ekanayake, Indika Bandara Gawarammana
BACKGROUND: Dengue is an arboviral infection classically presenting with fever, arthralgia, headache, and rashes. It is hyperendemic in Sri Lanka and has a major impact on health. Neurological complications of dengue fever are rare but have been reported in the literature. CASE PRESENTATION: A 60-year-old Sri Lankan man presented with a history of fever, arthralgia, and generalized malaise of 2 days duration. A diagnosis of dengue was confirmed with leukopenia, thrombocytopenia, and positive NS1 antigen done on day 2 without evidence of hemoconcentration...
May 15, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29756760/pre-clinical-antiviral-testing-for-dengue-virus-infection-in-mouse-models-and-its-association-with-clinical-studies
#6
Satoru Watanabe, Jenny Guek Hong Low, Subhash G Vasudevan
At present, there are no licensed antiviral drug against dengue virus (DENV) infection. Mouse models of DENV infection have been widely used for pre-clinical evaluation of antivirals. However, only in a few instances so far have the data obtained from pre-clinical mouse model testing been associated with data from clinical studies in humans. In this review, we focus on the antiviral drugs targeting viral replication that have been tested in animals/humans, and discuss how pre-clinical drug evaluation in suitable mouse/animal models may be more fruitfully used to inform early phase clinical testing...
May 14, 2018: ACS Infectious Diseases
https://www.readbyqxmd.com/read/29753850/role-of-mitogen-activated-protein-kinase-signaling-in-the-pathogenesis-of-dengue-virus-infection
#7
REVIEW
Gopinathan Pillai Sreekanth, Pa-Thai Yenchitsomanus, Thawornchai Limjindaporn
Dengue virus (DENV) infection is a disease that is endemic to many parts of the world, and its increasing prevalence ranks it among the diseases considered to be a significant threat to public health. The clinical manifestations of DENV infection range from mild dengue fever (DF) to more severe dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). Increased proinflammatory cytokines and vascular permeability, both of which cause organ injury, are the hallmarks of severe dengue disease. Signs of liver injury were observed in studies using hepatic cell lines, mouse models, and autopsy specimens from DENV-infected patients, and these signs substantiated the effects of inflammatory responses and hepatic cell apoptosis...
May 10, 2018: Cellular Signalling
https://www.readbyqxmd.com/read/29751486/current-strategies-for-inhibition-of-chikungunya-infection
#8
REVIEW
Bharat Bhusan Subudhi, Soma Chattopadhyay, Priyadarsee Mishra, Abhishek Kumar
Increasing incidences of Chikungunya virus (CHIKV) infection and co-infections with Dengue/Zika virus have highlighted the urgency for CHIKV management. Failure in developing effective vaccines or specific antivirals has fuelled further research. This review discusses updated strategies of CHIKV inhibition and provides possible future directions. In addition, it analyzes advances in CHIKV lifecycle, drug-target development, and potential hits obtained by in silico and experimental methods. Molecules identified with anti-CHIKV properties using traditional/rational drug design and their potential to succeed in subsequent stages of drug development have also been discussed...
May 3, 2018: Viruses
https://www.readbyqxmd.com/read/29740424/modulation-of-dengue-zika-virus-pathogenicity-by-antibody-dependent-enhancement-and-strategies-to-protect-against-enhancement-in-zika-virus-infection
#9
REVIEW
Rekha Khandia, Ashok Munjal, Kuldeep Dhama, Kumaragurubaran Karthik, Ruchi Tiwari, Yashpal Singh Malik, Raj Kumar Singh, Wanpen Chaicumpa
Antibody-dependent enhancement (ADE) is a phenomenon in which preexisting poorly neutralizing antibodies leads to enhanced infection. It is a serious concern with mosquito-borne flaviviruses such as Dengue virus (DENV) and Zika virus (ZIKV). In vitro experimental evidences have indicated the preventive, as well as a pathogenicity-enhancing role, of preexisting DENV antibodies in ZIKV infections. ADE has been confirmed in DENV but not ZIKV infections. Principally, the Fc region of the anti-DENV antibody binds with the fragment crystallizable gamma receptor (FcγR), and subsequent C1q interactions and immune effector functions are responsible for the ADE...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29720514/secretion-of-the-non-structural-protein-1-of-dengue-virus-from-infected-mosquito-cells-facts-and-speculations
#10
Ana C Alcalá, Laura A Palomares, Juan E Ludert
The dengue virus NS1 is a multifunctional glycoprotein. For decades, the notion in the field was that NS1 was secreted exclusively from vertebrate, but not mosquito, cells. However, recent evidence shows that mosquito cells also secrete NS1 efficiently. In this review, we discuss the evidence for dengue, and other flaviviruses, NS1 secretion from mosquito cells, differences between NS1 secreted from mosquito and vertebrate cells, and possible roles of soluble NS1 in the insect flavivirus vector.
May 2, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29718912/microrna-profiles-and-functions-in-mosquitoes
#11
Xinyu Feng, Shuisen Zhou, Jingwen Wang, Wei Hu
Mosquitoes are incriminated as vectors for many crippling diseases, including malaria, West Nile fever, Dengue fever, and other neglected tropical diseases (NTDs). microRNAs (miRNAs) can interact with multiple target genes to elicit biological functions in the mosquitoes. However, characterization and function of individual miRNAs and their potential targets have not been fully determined to date. We conducted a systematic review of published literature following PRISMA guidelines. We summarize the information about miRNAs in mosquitoes to better understand their metabolism, development, and responses to microorganisms...
May 2, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29706319/zika-virus-epidemiological-study-and-its-association-with-public-health-risk
#12
REVIEW
Rashed Noor, Tasnia Ahmed
Propagation of Zika virus has become an alarming global public health issue. The infection is spreading rapidly to different countries by several methods, especially by the transmission through traveling. Bangladesh is also at a risk to be affected with such newly viral infections. Though the virus initially appears to cause mild problems, the long term effects are more devastating to the next generation as seen in case of the delivery of the microcephalic babies. Current review discussed the epidemiologic era of the virus; i...
April 26, 2018: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/29695688/-human-genetic-predisposition-to-diseases-caused-by-viruses-from-flaviviridae-family
#13
N S Yudin, A V Barkhash, V N Maksimov, E V Ignatieva, A G Romaschenko
The identification of human predisposition genes to severe forms of infectious diseases is important for understanding the mechanisms of pathogenesis, as well as for the detection of the risk groups. This will allow one to carry out targeted vaccination and preventive therapy. The most common approaches to the genetic risk estimation include conducting association studies, in which the groups of patients and control individuals are compared using both preliminarily selected candidate genes and using genome-wide analysis...
March 2018: Molekuliarnaia Biologiia
https://www.readbyqxmd.com/read/29695282/effects-of-desiccation-stress-on-adult-female-longevity-in-aedes-aegypti-and-ae-albopictus-diptera-culicidae-results-of-a-systematic-review-and-pooled-survival-analysis
#14
Chris A Schmidt, Genevieve Comeau, Andrew J Monaghan, Daniel J Williamson, Kacey C Ernst
BACKGROUND: Transmission dynamics of mosquito-borne viruses such as dengue, Zika and chikungunya are affected by the longevity of the adult female mosquito. Environmental conditions influence the survival of adult female Aedes mosquitoes, the primary vectors of these viruses. While the association of temperature with Aedes mortality has been relatively well-explored, the role of humidity is less established. The current study's goals were to compile knowledge of the influence of humidity on adult survival in the important vector species Aedes aegypti and Ae...
April 25, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29692243/isatin-derivatives-and-their-antiviral-properties-against-arboviruses-a-review
#15
Paulo Andre Teixeira De Moraes Gomes, Lindomar Jose Pena, Ana Cristina Lima Leite
Arboviruses have been spreading rapidly throughout the Western Hemisphere in recent decades. Among the arboviruses with high morbidity and mortality are members of the Alphavirus and Flavivirus genera. Within the first genus, Chikungunya virus (CHIKV) is considered one of the most challenging human arboviral infections with global significance and without any specific antiviral agent. Flaviviruses are some of the most important causes of encephalitis, haemorrhagic disease, and developmental defects. Japanese encephalitis virus (JEV), West Nile virus (WNV), dengue virus (DENV) and Zika virus (ZIKV) are examples of flaviviruses without clinically approved antiviral agents...
April 23, 2018: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/29691914/definitions-for-warning-signs-and-signs-of-severe-dengue-according-to-the-who-2009-classification-systematic-review-of-literature
#16
REVIEW
Mostafa Ebraheem Morra, Ahmed M A Altibi, Somia Iqtadar, Le Huu Nhat Minh, Sameh Samir Elawady, Asma Hallab, Abdelrahman Elshafay, Omer Abedlbagi Omer, Ahmed Iraqi, Purushottam Adhikari, Jonair Hussein Labib, Khaled Mosaad Elhusseiny, Ahmed Elgebaly, Sophie Yacoub, Le Thi Minh Huong, Kenji Hirayama, Nguyen Tien Huy
Since warning signs and signs of severe dengue are defined differently between studies, we conducted a systematic review on how researchers defined these signs. We conducted an electronic search in Scopus to identify relevant articles, using key words including dengue, "warning signs," "severe dengue," and "classification." A total of 491 articles were identified through this search strategy and were subsequently screened by 2 independent reviewers for definitions of any of the warning or severe signs in the 2009 WHO dengue classification...
April 24, 2018: Reviews in Medical Virology
https://www.readbyqxmd.com/read/29690895/history-epidemiology-and-diagnostics-of-dengue-in-the-american-and-brazilian-contexts-a-review
#17
REVIEW
Tiago Souza Salles, Thayane da Encarnação Sá-Guimarães, Evelyn Seam Lima de Alvarenga, Victor Guimarães-Ribeiro, Marcelo Damião Ferreira de Meneses, Patricia Faria de Castro-Salles, Carlucio Rocha Dos Santos, Ana Claudia do Amaral Melo, Marcia Regina Soares, Davis Fernandes Ferreira, Monica Ferreira Moreira
Dengue virus (DENV), an arbovirus transmitted by mosquitoes, has become a major threat to American human life, reaching approximately 23 million cases from 1980 to 2017. Brazil is among the countries most affected by this terrible viral disease, with 13.6 million cases. DENV has four different serotypes, DENV1-4, which show a broad clinical spectrum. Dengue creates a staggering epidemiological and economic burden for endemic countries. Without a specific therapy and with a commercial vaccine that presents some problems relative to its full effectiveness, initiatives to improve vector control strategies, early disease diagnostics and the development of vaccines and antiviral drugs are priorities...
April 24, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29678952/subverting-the-mechanisms-of-cell-death-flavivirus-manipulation-of-host-cell-responses-to-infection
#18
REVIEW
Elisa Vicenzi, Isabel Pagani, Silvia Ghezzi, Sarah L Taylor, Timothy R Rudd, Marcelo A Lima, Mark A Skidmore, Edwin A Yates
Viruses exploit host metabolic and defence machinery for their own replication. The flaviviruses, which include Dengue (DENV), Yellow Fever (YFV), Japanese Encephalitis (JEV), West Nile (WNV) and Zika (ZIKV) viruses, infect a broad range of hosts, cells and tissues. Flaviviruses are largely transmitted by mosquito bites and humans are usually incidental, dead-end hosts, with the notable exceptions of YFV, DENV and ZIKV. Infection by flaviviruses elicits cellular responses including cell death via necrosis, pyroptosis (involving inflammation) or apoptosis (which avoids inflammation)...
April 20, 2018: Biochemical Society Transactions
https://www.readbyqxmd.com/read/29678172/validity-of-international-classification-of-diseases-icd-coding-for-dengue-infections-in-hospital-discharge-records-in-malaysia
#19
Yuan-Liang Woon, Keng-Yee Lee, Siti Fatimah Zahra Mohd Anuar, Pik-Pin Goh, Teck-Onn Lim
BACKGROUND: Hospitalization due to dengue illness is an important measure of dengue morbidity. However, limited studies are based on administrative database because the validity of the diagnosis codes is unknown. We validated the International Classification of Diseases, 10th revision (ICD) diagnosis coding for dengue infections in the Malaysian Ministry of Health's (MOH) hospital discharge database. METHODS: This validation study involves retrospective review of available hospital discharge records and hand-search medical records for years 2010 and 2013...
April 20, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29674002/dengue-virus-ns2-and-ns4-minor-proteins-mammoth-roles
#20
REVIEW
Sindhoora Bhargavi Gopala Reddy, Wei-Xin Chin, Nanjunda Swamy Shivananju
Despite the ever increasing global incidence of dengue fever, there are no specific chemotherapy regimens for its treatment. Structural studies on dengue virus (DENV) proteins have revealed potential drug targets. Major DENV proteins such as the envelope protein and non-structural (NS) proteins 3 and 5 have been extensively investigated in antiviral studies, but with limited success in vitro. However, the minor NS proteins NS2 and NS4 have remained relatively underreported. Emerging evidence indicating their indispensable roles in virus propagation and host immunomodulation should encourage us to target these proteins for drug discovery...
April 16, 2018: Biochemical Pharmacology
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