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Dengue review

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https://www.readbyqxmd.com/read/29147793/pharmacophoric-characteristics-of-dengue-virus-ns2b-ns3pro-inhibitors-a-systematic-review-of-the-most-promising-compounds
#1
REVIEW
Camyla Alves Leonel, William Gustavo Lima, Michelli Dos Santos, Ariane Coelho Ferraz, Alex Gutterres Taranto, José Carlos de Magalhães, Luciana Lara Dos Santos, Jaqueline Maria Siqueira Ferreira
Dengue virus (DENV) infection can lead to a wide range of clinical manifestations, including fatal hemorrhagic complications. There is a need to find effective pharmacotherapies to treat this disease due to the lack of specific immunotherapies and antiviral drugs. That said, the DENV NS2B/NS3pro protease complex is essential in both the viral multiplication cycle and in disease pathogenesis, and is considered a promising target for new antiviral therapies. Here, we performed a systematic review to evaluate the pharmacophoric characteristics of promising compounds against NS2B/NS3pro reported in the past 10 years...
November 16, 2017: Archives of Virology
https://www.readbyqxmd.com/read/29137006/definition-of-persistent-vomiting-in-current-medical-literature-a-systematic-review
#2
Mostafa Ebraheem Morra, Abdelrahman Elshafay, Aswin Ratna Kansakar, Ghaleb Muhammad Mehyar, Nguyen Phan Hoang Dang, Omar Mohamed Mattar, Somia Iqtadar, Mostafa Reda Mostafa, Vu Ngoc Hai, Tran Le-Huy Vu, Ahmed Abdelmotaleb Ghazy, Fatima Kaboub, Nguyen Tien Huy, Kenji Hirayama
BACKGROUND AND AIM: Persistent vomiting is mentioned as a symptom of a large variety of systemic disorders. It is commonly used interchangeably with chronic, recurrent, or intractable vomiting and widely used as a warning sign of severe illness in dengue infection. However, it has been poorly defined in the medical literature. Therefore, we aimed to systematically review a definition of persistent vomiting in the medical literature. METHODS: A systematic search was done through; PubMed, Google Scholar, Web of Science, Scopus, VHL, WHO-GHL, Grey Literature Report, POPLINE, and SIGLE for the last 10 years...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29135369/t-cell-immunity-to-zika-and-dengue-viral-infections
#3
Jinsheng Wen, Sujan Shresta
The 2015-2016 Zika virus (ZIKV) outbreak in the Americas has brought this relatively unknown flavivirus into the spotlight as the etiologic agent of congenital Zika syndrome in newborns and, potentially, of Guillain-Barré syndrome in adults. ZIKV shares a high degree of amino acid sequence homology with the closely related flavivirus Dengue virus (DENV). Due to the paucity of research investigating T cell-mediated immune responses to ZIKV, the precise roles of T cells in protection against and pathogenesis of ZIKV infection are unclear...
November 2017: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/29131357/zika-virus-what-we-need-to-know
#4
REVIEW
Farakh Javed, Khanzadi N Manzoor, Mubashar Ali, Irshad U Haq, Abid A Khan, Assad Zaib, Sobia Manzoor
Zika virus is one of the emerging viruses and is of significant threat to human health globally. It is a mosquito borne flavivirus similar to dengue, yellow fever, and West Nile viruses. It was reported about 5 decades ago and then it spreads to different parts of the world. Large outbreaks were reported on Yap Islands in 2007. Now it has gained wide attention globally by health communities. Major vector for virus transmission is Aedes aegypti mosquito. ZIKV infection is mostly asymptomatic but it is also responsible to cause mild influenza like illness to serious manifestations...
November 13, 2017: Journal of Basic Microbiology
https://www.readbyqxmd.com/read/29119088/neurological-manifestations-of-dengue-infection
#5
REVIEW
Guo-Hong Li, Zhi-Jie Ning, Yi-Ming Liu, Xiao-Hong Li
Dengue counts among the most commonly encountered arboviral diseases, representing the fastest spreading tropical illness in the world. It is prevalent in 128 countries, and each year >2.5 billion people are at risk of dengue virus infection worldwide. Neurological signs of dengue infection are increasingly reported. In this review, the main neurological complications of dengue virus infection, such as central nervous system (CNS), peripheral nervous system, and ophthalmic complications were discussed according to clinical features, treatment and possible pathogenesis...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29107239/mini-review-gustatory-reception-of-chemicals-affecting-host-feeding-in-aedine-mosquitoes
#6
REVIEW
Jackson T Sparks, Joseph C Dickens
Mosquitoes vector dangerous human diseases during blood feeding. Gustatory (taste) receptor neurons in the mosquito provide important chemical information including the nature and suitability of a potential host. Here we discuss the behavior, neurophysiology and molecular mechanisms associated with feeding in aedine mosquitoes, important vectors of emerging diseases including Zika fever, chikungunya and dengue fever. We describe how interactions between feeding stimulation and deterrency at the peripheral neural receptor level provide input to higher order neural processing centers affecting decisions to feed...
October 2017: Pesticide Biochemistry and Physiology
https://www.readbyqxmd.com/read/29095822/adherence-to-clinical-practice-guidelines-cpg-management-of-dengue-infection-in-adults-revised-2nd-edition
#7
Marzilawati Abd Rahman, Rafdzah Ahmad Zaki, Roza Sarimin, Mohd Izhar Ariff, Zailiza Suli, Maimunah Mahmud, Ker Hong Bee, Cecilia Anthonysamy, Azahirafairud Abdul Rahim, Balvinder Singh Gill, Shanti Rudra Deva, Ana Fizalinda Abdullah Sani, Erni Zurina Romli, Izzuna Mudla Mohamed Ghazali, Mohd Aminuddin Mohd Yusof, Nafisah Ahmad Lutfi, Shahril Effendi Shuib, Noormah Mohd Darus, Rugayah Bakri, 'Abqariyah Yahya
The Malaysian Dengue Clinical Practice Guidelines (CPG) have been developed to provide evidence-based guidance in the management of dengue infections. The use of these guidelines is essential to ensure its recommendations are being practiced. However, the adherence to the guidelines for management of dengue (revised 2nd edition) by healthcare providers still remains unknown. Therefore, the aim of this study was to evaluate the proportion among healthcare providers that adhere to this Dengue CPG. A retrospective cohort study of dengue cases registered from 1 January 2014 to 1 June 2015 was conducted in public hospitals and health clinics in Selangor, Putrajaya and Kuala Lumpur...
2017: PloS One
https://www.readbyqxmd.com/read/29093104/ability-to-serologically-confirm-recent-zika-virus-infection-in-areas-with-varying-past-incidence-of-dengue-virus-infection-united-states-and-territories-2016
#8
Nicole P Lindsey, J Erin Staples, Krista Powell, Ingrid B Rabe, Marc Fischer, Ann M Powers, Olga I Kosoy, Eric C Mossel, Jorge L Munoz-Jordan, Manuela Beltran, W Thane Hancock, Karrie-Ann E Toews, Esther M Ellis, Brett R Ellis, Amanda J Panella, Alison J Basile, Amanda E Calvert, Janeen Laven, Christin H Goodman, Carolyn V Gould, Stacey W Martin, Jennifer D Thomas, Julie Villanueva, Mary L Mataia, Rebecca Sciulli, Remedios Gose, A Christian Whelen, Susan L Hills
Background. Cross-reactivity within flavivirus antibody assays, produced by shared epitopes in the envelope proteins, can complicate serological diagnosis of Zika virus (ZIKAV) infection. We assessed the utility of the plaque reduction neutralization test (PRNT) to confirm recent ZIKAV infections and rule out misleading positive IgM results in areas with varying past dengue virus (DENV) infection incidence. Methods. We reviewed PRNT results of sera collected for diagnosis of ZIKAV infection from January 1 through August 31, 2016 with positive ZIKAV IgM results and ZIKAV and DENV PRNT performed...
November 1, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29081814/roles-of-interferons-in-pregnant-women-with-dengue-infection-protective-or-dangerous-factors
#9
REVIEW
Hao Zhang, Zhiyi He, Wenting Zeng, Hong-Juan Peng
Dengue infection is a serious public health problem in tropical and subtropical areas. With the recent outbreaks of Zika disease and its reported correlation with microcephaly, the large number of pregnancies with dengue infection has become a serious concern. This review describes the epidemiological characteristics of pregnancy with dengue and the initial immune response to dengue infection, especially in IFNs production in this group of patients. Dengue is much more prevalent in pregnant women compared with other populations...
2017: Canadian Journal of Infectious Diseases & Medical Microbiology
https://www.readbyqxmd.com/read/29074038/protection-of-the-house-against-chagas-disease-dengue-leishmaniasis-and-lymphatic-filariasis-a-systematic-review
#10
REVIEW
Olaf Horstick, Silvia Runge-Ranzinger
In light of the recent Zika virus outbreak, vector control has received renewed interest. However, which interventions are efficacious and community effective and how to best deliver them remains unclear. Following PRISMA guidelines, we did a systematic review to assess evidence for applied vector control interventions providing protection against Chagas disease, dengue, leishmaniasis, and lymphatic filariasis at the household level. We searched for published literature and grey literature between Jan 1, 1980, and Nov 30, 2015, and updated our search on April 2, 2017, using databases including the Cochrane, Embase, LILACS, PubMed, Web of Science, and WHOLIS...
October 23, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29063879/review-on-transovarial-transmission-potentiality-of-dengue-vectors-an-international-perspective-with-special-reference-to-north-eastern-region-of-india
#11
REVIEW
Monika Soni, Jitendra Sharma
Despite extensive research in vaccine development, there is at present no known method of controlling dengue except by the mosquito vectors. Virologic surveillance which involves the detection of dengue virus (DENV) in human serum and followed by isolation of virus using cell culture or mosquito inoculation is used as an early warning symptom to predict the outbreak. The technique is not much effective as the virus is in the human population. However, if the virus is detected in mosquito before it can infect humans could be more effective approach...
July 2017: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29054571/associations-of-dc-sign-cd209-promoter-336g-a-polymorphism-rs4804803-with-dengue-infection-a-systematic-review-and-meta-analysis
#12
Noel Pabalan, Suwit Chaisri, Sompong Tabunhan, Achara Phumyen, Hamdi Jarjanazi, Theodore S Steiner
BACKGROUND AND AIM: Dengue virus entry into a host is associated with a cell surface protein, DC-SIGN (dendritic cell-specific intercellular adhesion molecule-3 grabbing non-integrin). A common CD209-336G/A (rs4804803) polymorphism in DC-SIGN may affect severity of dengue virus infection (DEN) and incidence of dengue fever (DF) or the more severe dengue hemorrhagic fever (DHF). However, the reported associations of these two outcomes and CD-209 have been inconsistent, which prompted a meta-analysis to obtain more precise estimates...
October 18, 2017: Acta Tropica
https://www.readbyqxmd.com/read/29035317/systematic-review-land-cover-meteorological-and-socioeconomic-determinants-of-aedes-mosquito-habitat-for-risk-mapping
#13
REVIEW
Mohamed F Sallam, Chelsea Fizer, Andrew N Pilant, Pai-Yei Whung
Asian tiger and yellow fever mosquitoes (Aedes albopictus and Ae. aegypti) are global nuisances and are competent vectors for viruses such as Chikungunya (CHIKV), Dengue (DV), and Zika (ZIKV). This review aims to analyze available spatiotemporal distribution models of Aedes mosquitoes and their influential factors. A combination of five sets of 3-5 keywords were used to retrieve all relevant published models. Five electronic search databases were used: PubMed, MEDLINE, EMBASE, Scopus, and Google Scholar through 17 May 2017...
October 16, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29026637/a-review-of-selected-arboviruses-during-pregnancy
#14
REVIEW
Penélope Saldanha Marinho, Antonio José Cunha, Joffre Amim Junior, Arnaldo Prata-Barbosa
Arboviruses are emerging infectious diseases with the ability to expand geographically and rapidly affect large populations. The recent epidemic caused by the Zika virus in the Americas and congenital Zika syndrome associated with maternal infection has called out attention to the importance of studying arboviruses during pregnancy. This is a review on selected arboviruses infections during gestation, including Zika, Chikungunya, Dengue and Yellow Fever viruses. Issues such as historical overview, pathogenesis, transmission, clinical conditions, diagnosis, treatment and prevention are addressed...
2017: Maternal Health, Neonatology and Perinatology
https://www.readbyqxmd.com/read/29018589/neurological-complications-in-a-polynesian-traveler-with-dengue
#15
Maegan Lm Doi, Sydney Y Tatsuno, Gurdev Singh, Eric M Tatsuno, Marjorie M Mau
In recent times, there has been an increased focus on mosquito-borne Flaviviruses, in particular dengue and Zika. With the reappearance of dengue in Hawai'i and the mainland United States (US), clinicians should be aware of both the common presentations of dengue, as well as other less common complications associated with the disease. Dengue can result in neurologic disorders such as encephalopathy, encephalitis, immune-mediated syndromes, neuromuscular dysfunction, and neuro-ophthalmologic disorders. We present an interesting case of dengue that initially presented with classic symptoms (arthropathy, biphasic fever, and rash) and subsequently developed into a neurologic movement disorder with muscle tightening and twitching of the face, chest, and extremities...
October 2017: Hawai'i Journal of Medicine & Public Health: a Journal of Asia Pacific Medicine & Public Health
https://www.readbyqxmd.com/read/28993774/the-clinical-application-of-micrornas-in-infectious-disease
#16
REVIEW
Ruth E Drury, Daniel O'Connor, Andrew J Pollard
MicroRNAs (miRNAs) are short single-stranded non-coding RNA sequences that posttranscriptionally regulate up to 60% of protein encoding genes. Evidence is emerging that miRNAs are key mediators of the host response to infection, predominantly by regulating proteins involved in innate and adaptive immune pathways. miRNAs can govern the cellular tropism of some viruses, are implicated in the resistance of some individuals to infections like HIV, and are associated with impaired vaccine response in older people...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28991321/-role-of-dendritic-cells-in-infection-by-dengue-virus-targets-for-replication-and-immune-response
#17
Jahnnyer Martínez, Juan C Hernández, Silvio Urcuqui-Inchima
Dengue fever, caused by dengue virus (DENV) infection, is one of the most important diseases in the world, not only due to the high morbidity/mortality rates it causes, but also because of its great economic and social impact in tropical/subtropical countries. DENV infection has a wide range of clinical manifestations ranging from asymptomatic infection or infection with mild symptoms to severe dengue that can lead to death. At present, no etiological treatment or effective globally distributed vaccine against the four DENV serotypes exists...
June 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/28991189/translational-implication-of-galectin-9-in-the-pathogenesis-and-treatment-of-viral-infection
#18
REVIEW
Jenn-Haung Lai, Shue-Fen Luo, Mei-Yi Wang, Ling-Jun Ho
The interaction between galectin-9 and its receptor, Tim-3, triggers a series of signaling events that regulate immune responses. The expression of galectin-9 has been shown to be increased in a variety of target cells of many different viruses, such as hepatitis C virus (HCV), hepatitis B virus (HBV), herpes simplex virus (HSV), influenza virus, dengue virus (DENV), and human immunodeficiency virus (HIV). This enhanced expression of galectin-9 following viral infection promotes significant changes in the behaviors of the virus-infected cells, and the resulting events tightly correlate with the immunopathogenesis of the viral disease...
October 8, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28991176/innate-immune-evasion-mediated-by-flaviviridae-non-structural-proteins
#19
REVIEW
Shun Chen, Zhen Wu, Mingshu Wang, Anchun Cheng
Flaviviridae-caused diseases are a critical, emerging public health problem worldwide. Flaviviridae infections usually cause severe, acute or chronic diseases, such as liver damage and liver cancer resulting from a hepatitis C virus (HCV) infection and high fever and shock caused by yellow fever. Many researchers worldwide are investigating the mechanisms by which Flaviviridae cause severe diseases. Flaviviridae can interfere with the host's innate immunity to achieve their purpose of proliferation. For instance, dengue virus (DENV) NS2A, NS2B3, NS4A, NS4B and NS5; HCV NS2, NS3, NS3/4A, NS4B and NS5A; and West Nile virus (WNV) NS1 and NS4B proteins are involved in immune evasion...
October 7, 2017: Viruses
https://www.readbyqxmd.com/read/28977949/is-folfoxiri-alone-or-combined-with-targeted-therapy-administered-as-first-line-treatment-a-reasonable-choice-for-most-patients-with-mcrc-systematic-review-and-network-meta-analysis
#20
Mingyi Zhou, Ping Yu, Dengue Bilibili Hernick Davin, Yanrong Li, Yuanhe Wang, Lingyu Fu, Jingdong Zhang
Whether the intensive administration of folinic acid, 5-fluorouracil, oxaliplatin and irinotecan (FOLFOXIRI) alone or combined with target therapy as first-line treatment could improve the prognosis of metastatic colorectal cancer (mCRC) patients is controversial. PubMed, the Cochrane Collaboration Central Register of Controlled Clinical Trials, Cochrane Systematic Reviews, ClinicalTrials.gov, the databases of conferences were queried to identify RCTs evaluating the efficacies and toxicities of intensive therapies used for first-line treatment of mCRC patients...
September 22, 2017: Oncotarget
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