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Dengue review

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https://www.readbyqxmd.com/read/28917067/dengue-fever-clinical-features-of-567-consecutive-patients-admitted-to-a-tertiary-care-center-in-saudi-arabia
#1
Samar Badreddine, Fahmi Al-Dhaheri, Ammar Al-Dabbagh, Abdulrahman Al-Amoudi, Maged Al-Ammari, Nader Elatassi, Haytham Abbas, Rami Magliah, Abdulbasit Malibari, Hani Almoallim
To delineate the clinical features and outcomes of dengue infection and to guide clinician of early diagnosis and identification of risks factors for dengue hemorrhagic fever. Methods: This study is a retrospective cross-sectional. Clinical records of 567 patients with a confirmed diagnosis of dengue infection, admitted to a single hospital in Jeddah, Saudi Arabia, between January 2010 and  June 2014 were reviewed.  Results: Dengue infection was most common in adult males. Sixty-eight percent of infections were in Saudi nationals...
October 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28904181/progress-and-challenges-towards-point-of-care-diagnostic-development-for-dengue
#2
Junxiong Pang, Po Ying Chia, David C Lye, Yee Sin Leo
Dengue detection strategies involve viral RNA, antigen and/or antibody detection. Each strategy has its advantages and disadvantages. Optimal, user-friendly and rapid diagnostic tests based on immunochromatographic assays are pragmatic point-of-care-test (POCT) in dengue endemic regions where there are limited laboratory capabilities and optimal storage conditions. Increasingly, there is a greater public health significance for multiplexing assay to differentiate dengue from Zika or pathogens with similar clinical presentations...
September 13, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28892964/dengue-haemorrhagic-encephalitis-rare-case-report-with-review-of-literature
#3
Aditya Singh Kutiyal, Chetanya Malik, Gitika Hyanki
Dengue is an endemic arboviral infection prevalent especially in tropical countries including Southern and Southeast Asia. Central Nervous System (CNS) involvement in dengue infection is uncommon. Haemorrhagic encephalitis is a rare presentation in dengue. This is a case of a 58-year-old male who presented with fever, petechial rash and altered sensorium. Dengue serology IgM was reactive and MRI brain was suggestive of haemorrhagic encephalitis. Patient was managed in Intensive Care Unit (ICU) but eventually succumbed to his illness...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28879600/infections-and-the-kidney-a-tale-from-the-tropics
#4
Nivedita Kamath, Arpana Iyengar
Tropical infections are caused by a variety of bacteria, viruses and parasitic organisms across varying geographical regions and are more often reported in adults than in children. Most of the infections are acute, presenting as a febrile illness with involvement of multiple organ systems, including the kidney. The gamut of renal manifestations extends from asymptomatic urinary abnormalities to acute kidney injury and-albeit rarely-chronic kidney disease. Tropical infections can involve the glomerular, tubulointerstitial and vascular compartments of the kidney...
September 6, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28877637/ghost-probiotics-with-a-combined-regimen-a-novel-therapeutic-approach-against-the-zika-virus-an-emerging-world-threat
#5
Vivek K Bajpai, Vishal Chandra, Na-Hyung Kim, Rajni Rai, Pradeep Kumar, Kangmin Kim, Abhinav Aeron, Sun Chul Kang, D K Maheshwari, MinKyun Na, Irfan A Rather, Yong-Ha Park
The Zika virus (ZIKV) used to be an obscure flavivirus closely related to dengue virus (DENV). Transmission of this epidemic pathogen occurs mainly via mosquitoes, but it is also capable of placental and sexual transmission. Although the characteristics of these viruses are well defined, infections are unpredictable in terms of disease severity, unusual clinical manifestations, unexpected methods of transmission, long-term persistence, and the development of new strains. Recently, ZIKV has gained huge medical attention following the large-scale epidemics around the world, and reported cases of congenital abnormalities associated with Zika virus infections which have created a public health emergency of international concern...
September 7, 2017: Critical Reviews in Biotechnology
https://www.readbyqxmd.com/read/28874014/updated-reported-distribution-of-aedes-stegomyia-aegypti-and-aedes-stegomyia-albopictus-diptera-culicidae-in-the-united-states-1995-2016
#6
Micah B Hahn, Lars Eisen, Janet McAllister, Harry M Savage, John-Paul Mutebi, Rebecca J Eisen
Aedes (Stegomyia) aegypti (L.) and Aedes (Stegomyia) albopictus (Skuse) are potential vectors of Zika, dengue, and chikungunya viruses in the United States. A Zika virus outbreak in Florida in the summer of 2016, driven by Ae. aegypti and resulting in > 200 locally acquired cases of human illness, underscored the need for up-to-date information on the geographic distribution of Ae. aegypti and Ae. albopictus in the United States. In early 2016, we conducted a survey and literature review to compile county records for presence of Ae...
September 1, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/28859087/community-effectiveness-of-indoor-spraying-as-a-dengue-vector-control-method-a-systematic-review
#7
REVIEW
Moody Samuel, Dorit Maoz, Pablo Manrique, Tara Ward, Silvia Runge-Ranzinger, Joao Toledo, Ross Boyce, Olaf Horstick
BACKGROUND: The prevention and control of dengue rely mainly on vector control methods, including indoor residual spraying (IRS) and indoor space spraying (ISS). This study aimed to systematically review the available evidence on community effectiveness of indoor spraying. METHODS: A systematic review was conducted using seven databases (PubMed, EMBASE, LILACS, Web of Science, WHOLIS, Cochrane, and Google Scholar) and a manual search of the reference lists of the identified studies...
August 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28846635/regulation-of-apoptosis-during-flavivirus-infection
#8
REVIEW
Toru Okamoto, Tatsuya Suzuki, Shinji Kusakabe, Makoto Tokunaga, Junki Hirano, Yuka Miyata, Yoshiharu Matsuura
Apoptosis is a type of programmed cell death that regulates cellular homeostasis by removing damaged or unnecessary cells. Its importance in host defenses is highlighted by the observation that many viruses evade, obstruct, or subvert apoptosis, thereby blunting the host immune response. Infection with Flaviviruses such as Japanese encephalitis virus (JEV), Dengue virus (DENV) and West Nile virus (WNV) has been shown to activate several signaling pathways such as endoplasmic reticulum (ER)-stress and AKT/PI3K pathway, resulting in activation or suppression of apoptosis in virus-infected cells...
August 28, 2017: Viruses
https://www.readbyqxmd.com/read/28846489/zika-chikungunya-and-other-emerging-vector-borne-viral-diseases
#9
Scott C Weaver, Caroline Charlier, Nikos Vasilakis, Marc Lecuit
Arthropod-borne viruses (arboviruses) have a long history of emerging to infect humans, but during recent decades, they have been spreading more widely and affecting larger populations. This is due to several factors, including increased air travel and uncontrolled mosquito vector populations. Emergence can involve simple spillover from enzootic (wildlife) cycles, as in the case of West Nile virus accompanying geographic expansion into the Americas; secondary amplification in domesticated animals, as seen with Japanese encephalitis, Venezuelan equine encephalitis, and Rift Valley fever viruses; and urbanization, in which humans become the amplification hosts and peridomestic mosquitoes, mainly Aedes aegypti, mediate human-to-human transmission...
August 28, 2017: Annual Review of Medicine
https://www.readbyqxmd.com/read/28840835/skin-innate-immune-response-to-flaviviral-infection
#10
Magali Garcia, Michel Wehbe, Nicolas Lévêque, Charles Bodet
Skin is a complex organ and the largest interface of the human body exposed to numerous stress and pathogens. Skin is composed of different cell types that together perform essential functions such as pathogen sensing, barrier maintenance and immunity, at once providing the first line of defense against microbial infections and ensuring skin homeostasis. Being inoculated directly through the epidermis and the dermis during a vector blood meal, emerging Dengue, Zika and West Nile mosquito-borne viruses lead to the initiation of the innate immune response in resident skin cells and to the activation of dendritic cells, which migrate to the draining lymph node to elicit an adaptive response...
June 1, 2017: European Cytokine Network
https://www.readbyqxmd.com/read/28802204/humanized-mouse-models-to-study-human-cell-mediated-and-humoral-responses-to-dengue-virus
#11
REVIEW
Anuja Mathew
Several candidate dengue virus vaccines are in clinical trials and show promise as an effective measure to control dengue. However, it is becoming clear that additional vaccine candidates may be needed as there is concern about the durability of the immune response to all four serotypes of vaccine components and efficacy varies dependent on the immune status of the individual. The lack of an appropriate animal model to mimic human dengue has deterred the development of vaccines and anti-viral therapies to dengue virus...
August 9, 2017: Current Opinion in Virology
https://www.readbyqxmd.com/read/28791003/dengue-virus-glycosylation-what-do-we-know
#12
REVIEW
Sally S L Yap, Terry Nguyen-Khuong, Pauline M Rudd, Sylvie Alonso
In many infectious diseases caused by either viruses or bacteria, pathogen glycoproteins play important roles during the infection cycle, ranging from entry to successful intracellular replication and host immune evasion. Dengue is no exception. Dengue virus glycoproteins, envelope protein (E) and non-structural protein 1 (NS1) are two popular sub-unit vaccine candidates. E protein on the virion surface is the major target of neutralizing antibodies. NS1 which is secreted during DENV infection has been shown to induce a variety of host responses through its binding to several host factors...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28763150/pneumonia-in-the-tropics
#13
REVIEW
Tow Keang Lim, Wen Ting Siow
Pneumonia in the tropics poses a heavy disease burden. The complex interplay of climate change, human migration influences and socio-economic factors lead to changing patterns of respiratory infections in tropical climate but also increasingly in temperate countries. Tropical and poorer countries, especially South East Asia, also bear the brunt of the global tuberculosis (TB) pandemic, accounting for almost one-third of the burden. But, as human migration patterns evolve, we expect to see more TB cases in higher income as well as temperate countries, and rise in infections like scrub typhus from ecotourism activities...
August 1, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28755145/mosquito-control-with-green-nanopesticides-towards-the-one-health-approach-a-review-of-non-target-effects
#14
Giovanni Benelli, Filippo Maggi, Roman Pavela, Kadarkarai Murugan, Marimuthu Govindarajan, Baskaralingam Vaseeharan, Riccardo Petrelli, Loredana Cappellacci, Suresh Kumar, Anders Hofer, Mohammad Reza Youssefi, Abdullah A Alarfaj, Jiang-Shiou Hwang, Akon Higuchi
The rapid spread of highly aggressive arboviruses, parasites, and bacteria along with the development of resistance in the pathogens and parasites, as well as in their arthropod vectors, represents a huge challenge in modern parasitology and tropical medicine. Eco-friendly vector control programs are crucial to fight, besides malaria, the spread of dengue, West Nile, chikungunya, and Zika virus, as well as other arboviruses such as St. Louis encephalitis and Japanese encephalitis. However, research efforts on the control of mosquito vectors are experiencing a serious lack of eco-friendly and highly effective pesticides, as well as the limited success of most biocontrol tools currently applied...
July 28, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28748176/global-epidemiology-of-dengue-outbreaks-in-1990-2015-a-systematic-review-and-meta-analysis
#15
Congcong Guo, Zixing Zhou, Zihao Wen, Yumei Liu, Chengli Zeng, Di Xiao, Meiling Ou, Yajing Han, Shiqi Huang, Dandan Liu, Xiaohong Ye, Xiaoqian Zou, Jing Wu, Huanyu Wang, Eddy Y Zeng, Chunxia Jing, Guang Yang
Dengue is an arthropod-borne infectious disease caused by dengue virus (DENV) infection and transmitted by Aedes mosquitoes. Approximately 50-100 million people are infected with DENV each year, resulting in a high economic burden on both governments and individuals. Here, we conducted a systematic review and meta-analysis to summarize information regarding the epidemiology, clinical characteristics, and serotype distribution and risk factors for global dengue outbreaks occurring from 1990 to 2015. We searched the PubMed, Embase and Web of Science databases through December 2016 using the term "dengue outbreak...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28740942/anti-viral-effects-of-medicinal-plants-in-the-management-of-dengue-a-systematic-review
#16
REVIEW
Éric Heleno Freira Ferreira Frederico, André Luiz Bandeira Dionísio Cardoso, Eloá Moreira-Marconi, Danúbia da Cunha de Sá-Caputo, Carlos Alberto Sampaio Guimarães, Carla da Fontoura Dionello, Danielle Soares Morel, Laisa Liane Paineiras-Domingos, Patricia Lopes de Souza, Samuel Brandão-Sobrinho-Neto, Rafaelle Pacheco Carvalho-Lima, Eliane de Oliveira Guedes-Aguiar, Rebeca Graça Costa-Cavalcanti, Cristiane Ribeiro Kutter, Mario Bernardo-Filho
BACKGROUND: Dengue is considered as an important arboviral disease. Safe, low-cost, and effective drugs that possess inhibitory activity against dengue virus (DENV) are mostly needed to try to combat the dengue infection worldwide. Medicinal plants have been considered as an important alternative to manage several diseases, such as dengue. As authors have demonstrated the antiviral effect of medicinal plants against DENV, the aim of this study was to review systematically the published research concerning the use of medicinal plants in the management of dengue using the PubMed database...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28738211/the-immunopathology-of-dengue-and-zika-virus-infections
#17
REVIEW
Abigail Culshaw, Juthathip Mongkolsapaya, Gavin R Screaton
A large proportion of the world's population live in areas with dengue virus (DENV) transmission resulting in tens of millions of symptomatic dengue cases each year. Serious complications following DENV infection occur more frequently in those suffering from a second or subsequent infection implicating virus-specific immunity as having a role in pathogenesis. In recent years outbreaks of the related Zika virus (ZIKV) have been associated with birth defects and neurological complications. As DENV and ZIKV share a viral vector sequential infections can occur...
July 21, 2017: Current Opinion in Immunology
https://www.readbyqxmd.com/read/28732476/evaluation-of-creatine-kinase-and-liver-enzymes-in-identification-of-severe-dengue
#18
Saiful Safuan Md Sani, Winn Hui Han, Mohamad Adam Bujang, Hui Jen Ding, Kiah Loon Ng, Mohd Azizuddin Amir Shariffuddin
BACKGROUND: Existing biomarkers such as AST, ALT and hematocrit have been associated with severe dengue but evidence are mixed. Recently, interests in creatine kinase as a dengue biomarker have risen. These biomarkers represent several underlying pathophysiological processes in dengue. Hence, we aimed to assess AST, ALT, CK and hematocrit in identification of severe dengue and to assess the correlational relationship amongst common biomarkers of dengue. METHODS: This was a retrospective cohort study of confirmed dengue patients who were warded in Kuala Lumpur Hospital between December 2014 and January 2015...
July 21, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28730853/dengue-in-the-elderly-a-review
#19
Ray Junhao Lin, Tau Hong Lee, Yee Sin Leo
Changing dengue epidemiological trends have resulted in a shift in the disease burden to the adult population. Older adults suffer from poorer outcomes as compared to their younger counterparts, making clinical management of this sub-population particularly challenging. Areas covered: We present a review of the current literature on the changing epidemiology of dengue in the elderly, the atypical features of the clinical disease in this population with emphasis on severe disease presentations and challenges in the current management strategies...
August 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/28727779/contemporary-status-of-insecticide-resistance-in-the-major-aedes-vectors-of-arboviruses-infecting-humans
#20
REVIEW
Catherine L Moyes, John Vontas, Ademir J Martins, Lee Ching Ng, Sin Ying Koou, Isabelle Dusfour, Kamaraju Raghavendra, João Pinto, Vincent Corbel, Jean-Philippe David, David Weetman
Both Aedes aegytpi and Ae. albopictus are major vectors of 5 important arboviruses (namely chikungunya virus, dengue virus, Rift Valley fever virus, yellow fever virus, and Zika virus), making these mosquitoes an important factor in the worldwide burden of infectious disease. Vector control using insecticides coupled with larval source reduction is critical to control the transmission of these viruses to humans but is threatened by the emergence of insecticide resistance. Here, we review the available evidence for the geographical distribution of insecticide resistance in these 2 major vectors worldwide and map the data collated for the 4 main classes of neurotoxic insecticide (carbamates, organochlorines, organophosphates, and pyrethroids)...
July 2017: PLoS Neglected Tropical Diseases
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