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https://www.readbyqxmd.com/read/28731923/human-bocavirus-can-it-trigger-hemophagocytic-lymphohistiocytosis
#1
Sevgen Tanir Basaranoglu, Kubra Aykac, Yasemin Ozsurekci, Inci Bajin, Betul Tavil, Fatma Gumruk, Mehmet Ceyhan
With improvements in molecular diagnostic methods, report of Human bocavirus (HBoV) as an etiologic agent in many studies on viral respiratory and gastrointestinal infections has been increasing. Two pediatric patients who presented with secondary hemophagocytic lymphohistiocytosis were examined for etiologic causes, including viruses. Whole bacterial and fungal cultures and viral serological studies were negative. Viral polymerase chain reaction of nasopharyngeal secretions showed HBoV. One was successfully treated with intravenous immunoglobulins, whereas the other died with multiorgan failure...
July 20, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28719504/severe-lower-respiratory-tract-infection-caused-by-human-bocavirus-1-in-an-infant
#2
Vesa Eskola, Man Xu, Maria Söderlund-Venermo
We report a case of human bocavirus 1 (HBoV1) bronchiolitis that led to life-threatening respiratory failure in a 9-month-old boy with no other pathogens detected. The virus-specific diagnosis was confirmed with the detection of HBoV1 DNA in respiratory samples and both DNA and immunoglobulins M and G to HBoV1 in serum samples.
July 13, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28716110/phylogenic-analysis-of-human-bocavirus-detected-in-children-with-acute-respiratory-infection-in-yaounde-cameroon
#3
Sebastien Kenmoe, Marie-Astrid Vernet, Mohamadou Njankouo-Ripa, Véronique Beng Penlap, Astrid Vabret, Richard Njouom
OBJECTIVE: Human Bocavirus (HBoV) was first identified in 2005 and has been shown to be a common cause of respiratory infections and gastroenteritis in children. In a recent study, we found that 10.7% of children with acute respiratory infections (ARI) were infected by HBoV. Genetic characterization of this virus remains unknown in Central Africa, particularly in Cameroon Leeding us to evaluate the molecular characteristics of HBoV strains in Cameroonian children with ARI. RESULTS: Phylogenetic analysis of partial HBoV VP1/2 sequences showed a low level of nucleotide variation and the circulation of HBoV genotype 1 (HBoV-1) only...
July 17, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28708249/the-impact-of-anthropogenic-pressure-on-the-virological-quality-of-water-from-the-tiber-river-italy
#4
G La Rosa, I Sanseverino, S Della Libera, M Iaconelli, V E V Ferrero, A Barra Caracciolo, T Lettieri
The objective of the present study was to assess the occurrence of major waterborne enteric viruses (enterovirus, norovirus, adenovirus, rotavirus, hepatitis A and E virus) along the Tiber River in Italy, in areas affected by different kinds of anthropogenic pressure (agricultural, urban, industrial, and pristine). Moreover, in light of the recent abundant detection of human bocavirus in urban wastewater samples in Italy, the occurrence of this virus was also assessed. Virus detection was based on nested PCR followed by sequencing, and on Real Time PCR...
July 14, 2017: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/28673837/respiratory-viruses-detected-in-mexican-children-younger-than-5-years-old-with-community-acquired-pneumonia-a-national-multicenter-study
#5
Rosa María Wong-Chew, Miguel L García-León, Daniel E Noyola, Luis F Pérez-González, Jesús Gaitán-Meza, Alberto Villaseñor-Sierra, Gerardo Martínez-Aguilar, Victor Hugo Rivera-Nuñez, Oscar A Newton-Sánchez, Verónica Firo-Reyes, Carlos N Del Río-Almendarez, Alejandra Pamela González-Rodríguez, Enrique R Ortiz-García, Susana Navarrete-Navarro, Carmen Soria-Rodríguez, Adoniram Carrasco-Castillo, Eneida Sánchez-Medina, Irma López-Martínez, Teresa Hernández-Andrade, Celia M Alpuche-Aranda, José I Santos-Preciado
BACKGROUND: Acute respiratory infections are the leading cause of mortality in children worldwide, especially in developing countries. Pneumonia accounts for 16% of all deaths of children under 5 years of age and was the cause of death of 935000 children in 2015. Despite its frequency and severity, information regarding its etiology is limited. The aim of this study was to identify respiratory viruses associated with community-acquired pneumonia (CAP) in children younger than 5 years old...
June 30, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28672995/human-bocavirus-induces-apoptosis-and-autophagy-in-human-bronchial-epithelial-cells
#6
You-Ping Deng, Ying-Juan Liu, Zhan-Qiu Yang, Yan-Jun Wang, Bing-Yan He, Pin Liu
Human bocavirus (HBoV) is classified in the Bocavirus genus within the Parvoviridae family, first identified from children with respiratory diseases. Previous studies have investigated the stimulating effect of HBoV on cell apoptosis and autophagy. In the present study, human bronchial epithelial cells (HBECs) were utilized to examine the mechanism of HBoV recombination expressing vector (pWHL-1) on the promotion of cell apoptosis and autophagy. The results from the present study indicated that pWHL-1 inhibited the proliferation of HBECs in a time-dependent manner...
July 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28662150/a-viral-metagenomic-approach-on-a-non-metagenomic-experiment-mining-next-generation-sequencing-datasets-from-pig-dna-identified-several-porcine-parvoviruses-for-a-retrospective-evaluation-of-viral-infections
#7
Samuele Bovo, Gianluca Mazzoni, Anisa Ribani, Valerio Joe Utzeri, Francesca Bertolini, Giuseppina Schiavo, Luca Fontanesi
Shot-gun next generation sequencing (NGS) on whole DNA extracted from specimens collected from mammals often produces reads that are not mapped (i.e. unmapped reads) on the host reference genome and that are usually discarded as by-products of the experiments. In this study, we mined Ion Torrent reads obtained by sequencing DNA isolated from archived blood samples collected from 100 performance tested Italian Large White pigs. Two reduced representation libraries were prepared from two DNA pools constructed each from 50 equimolar DNA samples...
2017: PloS One
https://www.readbyqxmd.com/read/28659483/human-bocavirus-1-is-a-novel-helper-for-adeno-associated-virus-replication
#8
Zekun Wang, Xuefeng Deng, Wei Zou, John F Engelhardt, Ziying Yan, Jianming Qiu
Human bocavirus 1 (HBoV1) is an autonomous parvovirus that infects well-differentiated primary human airway epithelia (HAE) in vitro. In human embryonic kidney (HEK) 293 cells, transfection of a duplex HBoV1 genome initiates viral DNA replication and produces progeny virions that are infectious in HAE. HBoV1 takes advantage of signaling pathways in the DNA damage response for efficient genome amplification in both well-differentiated (non-dividing) HAE and dividing HEK293 cells. On the other hand, adeno-associated virus 2 (AAV2) is a helper-dependent dependoparvovirus, and productive AAV2 replication requires co-infection with a helper virus (e...
June 28, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28657532/-human-bocavirus-1-role-in-the-acute-respiratory-infection-and-epidemiology-in-cordoba-argentina
#9
REVIEW
María Pilar Adamo
Human bocavirus 1 (HBoV1) is an agent of acute respiratory infection frequent in children. It can cause pneumonia in infants, in the absence of epidemiological risk factors and comorbidities. Well-controlled studies of clinical cases and case series are still useful for the characterization of the clinicoepideiological features of the infection, while research dives on the molecular biology of the virus and the virus-cell relationship allowing to unveil tha natural history of the infection. This article reviews the state of the art and future perspectives on this new human parvovirus and its etiological role in the respiratory pathology...
2017: Revista de la Facultad de Ciencias Médicas
https://www.readbyqxmd.com/read/28649326/viral-gut-metagenomics-of-sympatric-wild-and-domestic-canids-and-monitoring-of-viruses-insights-from-an-endangered-wolf-population
#10
Nádia Conceição-Neto, Raquel Godinho, Francisco Álvares, Claude K Yinda, Ward Deboutte, Mark Zeller, Lies Laenen, Elisabeth Heylen, Sara Roque, Francisco Petrucci-Fonseca, Nuno Santos, Marc Van Ranst, João R Mesquita, Jelle Matthijnssens
Animal host-microbe interactions are a relevant concern for wildlife conservation, particularly regarding generalist pathogens, where domestic host species can play a role in the transmission of infectious agents, such as viruses, to wild animals. Knowledge on viral circulation in wild host species is still scarce and can be improved by the recent advent of modern molecular approaches. We aimed to characterize the fecal virome and identify viruses of potential conservation relevance of diarrheic free-ranging wolves and sympatric domestic dogs from Central Portugal, where a small and threatened wolf population persists in a highly anthropogenically modified landscape...
June 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28647513/respiratory-syncytial-virus-bronchiolitis-weather-conditions-and-air-pollution-in-an-italian-urban-area-an-observational-study
#11
Raffaella Nenna, Melania Evangelisti, Antonella Frassanito, Carolina Scagnolari, Alessandra Pierangeli, Guido Antonelli, Ambra Nicolai, Serena Arima, Corrado Moretti, Paola Papoff, Maria Pia Villa, Fabio Midulla
BACKGROUND: In this study we sought to evaluate the association between viral bronchiolitis, weather conditions, and air pollution in an urban area in Italy. METHODS: We included infants hospitalized for acute bronchiolitis from 2004 to 2014. All infants underwent a nasal washing for virus detection. A regional agency network collected meteorological data (mean temperature, relative humidity and wind velocity) and the following air pollutants: sulfur dioxide, nitrogen oxide, carbon monoxide, ozone, benzene and suspended particulate matter measuring less than 10µm (PM10) and less than 2...
June 22, 2017: Environmental Research
https://www.readbyqxmd.com/read/28639594/viral-aetiology-of-wheezing-in-children-under-five
#12
Prithi Sureka Mummidi, Radha Tripathy, Bhagirathi Dwibedi, Amarendra Mahapatra, Suryakanta Baraha
BACKGROUND & OBJECTIVES: Wheezing is a common problem in children under five with acute respiratory infections (ARIs). Viruses are known to be responsible for a considerable proportion of ARIs in children. This study was undertaken to know the viral aetiology of wheezing among the children less than five years of age, admitted to a tertiary care hospital in eastern India. METHODS: Seventy five children, under the age of five years admitted with wheezing, were included in the study...
February 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28634031/does-atopy-affect-the-course-of-viral-pneumonia
#13
S B Erdem, D Can, S Girit, F Çatal, V Şen, S Pekcan, H Yüksel, A Bingöl, I Bostancı, D Erge, R Ersu
BACKGROUND: The presence of atopy is considered as a risk factor for severe respiratory symptoms in children. The objective of this study was to examine the effect of atopy on the course of disease in children hospitalised with viral pneumonia. METHODS: Children between the ages of 1 and 6 years hospitalised due to viral pneumonia between the years of 2013 and 2016 were included to this multicentre study. Patients were classified into two groups as mild-moderate and severe according to the course of pneumonia...
June 17, 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/28616242/first-complete-genome-sequence-of-canine-bocavirus-2-in-mainland-china
#14
S-L Zhai, T Lin, Y-W Chen, R Liu, D-H Lv, X-H Wen, X-L Zhu, D Wang, F Li, W-K Wei
We obtained the first full-length genome sequence of canine bocavirus 2 (CBoV2) from the faeces of a healthy dog in Guangzhou city, Guangdong province, mainland China. The genome of GZHD15 consisted of 5059 nucleotides. Sequence analysis suggested that GZHD15 was close to a previously circulated Hong Kong isolate.
July 2017: New Microbes and New Infections
https://www.readbyqxmd.com/read/28507089/atypical-pneumonia-due-to-human-bocavirus-in-an-immunocompromised-patient
#15
Kaien Gu, Paul Van Caeseele, Kerry Dust, Julie Ho
No abstract text is available yet for this article.
May 15, 2017: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/28500864/identification-of-human-bocavirus-type-4-in-a-child-asymptomatic-for-respiratory-tract-infection-and-acute-gastroenteritis-goi%C3%A3-nia-goi%C3%A3-s-brazil
#16
Teresinha Teixeira de Sousa, Tâmera Nunes Vieira Almeida, Fabíola Souza Fiaccadori, Menira Souza, Kareem Rady Badr, Divina das Dôres de Paula Cardoso
Human Bocavirus (HBoV) has been identified from feces and respiratory samples from cases of both acute gastroenteritis and respiratory illness as well as in asymptomatic individuals. The aim of this study was to detect and characterize HBoV from fecal samples collected from hospitalized children aged less than five years old with no symptoms of respiratory tract infection (RTI) or acute gastroenteritis (AGE). The study involved 119 children and one fecal sample was collected from each participant between 2014 and 2015...
May 10, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28497552/a-novel-porcine-kobuvirus-emerged-in-piglets-with-severe-diarrhoea-in-china
#17
S-L Zhai, H Zhang, T Lin, S-N Chen, X Zhou, Q-L Chen, D-H Lv, X-H Wen, X-R Zhou, C-L Jia, W-K Wei
Since the first report of porcine kobuvirus (PKV) in 2008, it has been confirmed that PKV is widely present in several countries and plays an important role in diarrhoea outbreak in pigs. Studies have shown that the biggest difference among PKVs is the presence or absence of a specific 30-amino acid (aa) sequence in the 2B region of the polyprotein gene. Based on this unique feature, most PKV sequences could be divided into two groups (Group 1 without deletion and Group 2 with deletion), but a few sequences did not follow this rule due to possible recombination...
May 11, 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/28495649/identification-and-molecular-characterization-of-novel-primate-bocaparvoviruses-from-wild-western-lowland-gorillas-of-moukalaba-doudou-national-park-gabon
#18
Chimene Nze-Nkogue, Masayuki Horie, Shiho Fujita, Eiji Inoue, Etienne-François Akomo-Okoue, Makoto Ozawa, Alfred Ngomanda, Juichi Yamagiwa, Kyoko Tsukiyama-Kohara
Bocaparvoviruses have been studied extensively owing to their ability to cause respiratory illness or gastroenteritis in humans. Some bocaparvoviruses have been detected in non-human primates (gorillas and chimpanzees), but the diversity and evolution of these viruses are not fully understood. In this study, we collected 107 fecal samples from wild western lowland gorillas in Moukalaba-Doudou National Park in Gabon to investigate the presence of bocaparvoviruses. Using a combination of pan-bocaparvovirus PCR and individual identification by microsatellite genotyping, we found that two samples from two apparently healthy infant gorillas were positive for bocaparvovirus...
May 8, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28490200/human-bocavirus-type-1-capsid-facilitates-the-transduction-of-ferret-airways-by-adeno-associated-virus-genomes
#19
Ziying Yan, Zehua Feng, Xingshen Sun, Yulong Zhang, Wei Zou, Zekun Wang, Chandler Jensen-Cody, Bo Liang, Soo-Yeun Park, Jianming Qiu, John F Engelhardt
Human bocavirus type-1 (HBoV1) has a high tropism for the apical membrane of human airway epithelia. The packaging of a recombinant adeno-associated virus 2 (rAAV2) genome into HBoV1 capsid produces a chimeric vector (rAAV2/HBoV1) that also efficiently transduces human airway epithelia. As such, this vector is attractive for use in gene therapies to treat lung diseases such as cystic fibrosis. However, preclinical development of rAAV2/HBoV1 vectors has been hindered by the fact that humans are the only known host for HBoV1 infection...
May 10, 2017: Human Gene Therapy
https://www.readbyqxmd.com/read/28471975/thymic-stromal-lymphopoietin-il-33-and-periostin-in-hospitalized-infants-with-viral-bronchiolitis
#20
María Luz García-García, Cristina Calvo, Ana Moreira, José Antonio Cañas, Francisco Pozo, Beatriz Sastre, Sergio Quevedo, Inmaculada Casas, Victoria Del Pozo
Much attention has recently been focused on thymic stromal lymphopoietin (TSLP), IL-33, and periostin in allergic disease, but less is known about their role in viral bronchiolitis.The aim of the study was to investigate whether infants exhibit enhanced nasal airway secretion of TSLP, IL-33, and periostin during natural respiratory viral bronchiolitis compared to healthy controls.In total, 213 infants < 2 years of age, hospitalized with bronchiolitis from October/2013 to April/2016 were enrolled alongside 45 healthy infants...
May 2017: Medicine (Baltimore)
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