keyword
https://read.qxmd.com/read/38531173/quality-assurance-for-focused-ultrasound-induced-blood-brain-barrier-opening-procedure-using-passive-acoustic-detection
#1
JOURNAL ARTICLE
Chih-Yen Chien, Lu Xu, Jinyun Yuan, Siaka Fadera, Andrew H Stark, Umeshkumar Athiraman, Eric C Leuthardt, Hong Chen
BACKGROUND: Focused ultrasound (FUS) combined with microbubbles is a promising technique for noninvasive, reversible, and spatially targeted blood-brain barrier opening, with clinical trials currently ongoing. Despite the fast development of this technology, there is a lack of established quality assurance (QA) strategies to ensure procedure consistency and safety. To address this challenge, this study presents the development and clinical evaluation of a passive acoustic detection-based QA protocol for FUS-induced blood-brain barrier opening (FUS-BBBO) procedure...
March 25, 2024: EBioMedicine
https://read.qxmd.com/read/38516775/effect-of-treatment-with-carteolol-and-latanoprost-in-newly-diagnosed-primary-open-angle-glaucoma-on-peripapillary-vessel-density
#2
JOURNAL ARTICLE
Lestak Jan, Fus Martin, Pitrova Sarka
BACKGROUND AND AIM: In a previous follow-up of glaucoma patients taking carteolol or latanoprost, we found a greater progression of visual field changes with the prostaglandin than the betablocker. In the present study we compared the impact of carteolol and latanoprost on peripapillary vessel density in newly diagnosed primary open-angle glaucoma (POAG) patients. METHODS: The study consisted of two groups of POAG patients. There were 46 patient eyes treated with carteolol (Carteol LP 2%) in the first group and 52 eyes treated with latanoprost (Xalatan 0...
March 21, 2024: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://read.qxmd.com/read/38513659/structural-insights-into-a-functional-unit-from-an-immunogenic-mollusk-hemocyanin
#3
JOURNAL ARTICLE
Sebastián M Muñoz, Gabriel Vallejos-Baccelliere, Augusto Manubens, Michelle L Salazar, Andrey F Z Nascimento, Patricio Tapia-Reyes, Claudio Meneses, Andre L B Ambrosio, María Inés Becker, Victoria Guixé, Victor Castro-Fernandez
Mollusk hemocyanins, among the largest known proteins, are used as immunostimulants in biomedical and clinical applications. The hemocyanin of the Chilean gastropod Concholepas concholepas (CCH) exhibits unique properties, which makes it safe and effective for human immunotherapy, as observed in animal models of bladder cancer and melanoma, and dendritical cell vaccine trials. Despite its potential, the structure and amino acid sequence of CCH remain unknown. This study reports two sequence fragments of CCH, representing three complete functional units (FUs)...
March 14, 2024: Structure
https://read.qxmd.com/read/38512820/mutations-in-human-prion-like-domains-pathogenic-but-not-always-amyloidogenic
#4
REVIEW
Andrea Bartolomé-Nafría, Javier García-Pardo, Salvador Ventura
Heterogeneous nuclear ribonucleoproteins (hnRNPs) are multifunctional proteins with integral roles in RNA metabolism and the regulation of alternative splicing. These proteins typically contain prion-like domains of low complexity (PrLDs or LCDs) that govern their assembly into either functional or pathological amyloid fibrils. To date, over 60 mutations targeting the LCDs of hnRNPs have been identified and associated with a spectrum of neurodegenerative diseases including amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and Alzheimer's disease (AD)...
December 2024: Prion
https://read.qxmd.com/read/38508082/an-8%C3%A2-mm-endoscopic-histotripsy-array-with-integrated-high-resolution-ultrasound-imaging
#5
JOURNAL ARTICLE
Matthew G Mallay, Thomas G Landry, Jeremy A Brown
An 8 mm diameter, image-guided, annular array histotripsy transducer was fabricated and characterized. The array was laser etched on a 5 MHz, 1-3 dice and fill, PZT-5H/epoxy composite with a 45 % volume fraction. Flexible PCBs were used to electrically connect to the array elements using wirebonds. The array was backed with a low acoustic impedance epoxy mixture. A 3.6 by 3.8 mm, 64-element, 30 MHz phased array imaging probe was positioned in the center hole, to co-align the imaging plane with the bubble cloud produced by the therapy array...
March 17, 2024: Ultrasonics
https://read.qxmd.com/read/38506112/endogenous-ewsr1-exists-in-two-visual-modalities-that-reflect-its-associations-with-nucleic-acids-and-concentration-at-sites-of-active-transcription
#6
JOURNAL ARTICLE
Soumya Sundara Rajan, Vernon J Ebegboni, Patricio Pichling, Katelyn R Ludwig, Tamara L Jones, Raj Chari, Andy Tran, Michael J Kruhlak, Jadranka Loncarek, Natasha J Caplen
EWSR1 is a member of the FET family of nucleic acid binding proteins that includes FUS and TAF15. Here, we report the systematic analysis of endogenous EWSR1's cellular organization in human cells. We demonstrate that EWSR1, which contains low complexity and nucleic acid binding domains, is present in cells in faster and slower-recovering fractions, indicative of a protein undergoing both rapid exchange and longer-term interactions. The employment of complementary high-resolution imaging approaches shows EWSR1 exists in two visual modalities, a distributed state which is present throughout the nucleoplasm, and a concentrated state consistent with the formation of foci...
March 20, 2024: Molecular and Cellular Biology
https://read.qxmd.com/read/38503996/tumor-suppression-effect-of-ultrasound-sensitive-nanoparticles-with-focused-ultrasound-in-a-pancreas-cancer-xenograft-model
#7
JOURNAL ARTICLE
Soojin Kim, Jae Young Lee, Eun-Joo Park, Yun Deok Ahn, Yuri Cheon, Wonchul Sim, Hak Jong Lee
BACKGROUND: We investigated the tumor suppression effect of an ultrasound-sensitive doxorubicin-loaded liposome-based nanoparticle, IMP301, to enhance the synergistic effect with focused ultrasound (FUS) in an animal model of pancreatic cancer. METHODS: Thirty nude mice with xenografts of PANC-1 human pancreatic cancer cells were randomly and prospectively allocated to 6 different groups (5 per group) each for Study-1 (dose-response test) and Study-2 (synergistic effect test)...
March 20, 2024: European Radiology Experimental
https://read.qxmd.com/read/38500932/mri-guided-focused-ultrasound-for-the-treatment-of-dystonia-a-narrative-review
#8
REVIEW
Sheikh Muktadir Bin Momin, Kristian Aquilina, Harry Bulstrode, Takaomi Taira, Suneil Kalia, Ammar Natalwala
Contemporary surgical management of dystonia includes neuromodulation via deep brain stimulation (DBS) or ablative techniques such as radiofrequency (RF) ablation. MRI-guided focused ultrasound (MRgFUS) is an emerging modality that uses high-intensity ultrasound to precisely ablate targets in the brain; this is incisionless, potentially avoiding the surgical risks of a burr hole and transcortical tract to reach the anatomical target. There is some evidence of efficacy in essential tremor and Parkinson's disease (PD), but, to date, there is no study aggregating the evidence of MRgFUS in dystonia...
February 2024: Curēus
https://read.qxmd.com/read/38500677/invertebrate-genetic-models-of-amyotrophic-lateral-sclerosis
#9
REVIEW
LiJun Zhou, RenShi Xu
Amyotrophic lateral sclerosis (ALS) is a common adult-onset neurodegenerative disease characterized by the progressive death of motor neurons in the cerebral cortex, brain stem, and spinal cord. The exact mechanisms underlying the pathogenesis of ALS remain unclear. The current consensus regarding the pathogenesis of ALS suggests that the interaction between genetic susceptibility and harmful environmental factors is a promising cause of ALS onset. The investigation of putative harmful environmental factors has been the subject of several ongoing studies, but the use of transgenic animal models to study ALS has provided valuable information on the onset of ALS...
2024: Frontiers in Molecular Neuroscience
https://read.qxmd.com/read/38499535/htra1-disaggregates-%C3%AE-synuclein-amyloid-fibrils-and-converts-them-into-non-toxic-and-seeding-incompetent-species
#10
JOURNAL ARTICLE
Sheng Chen, Anuradhika Puri, Braxton Bell, Joseph Fritsche, Hector H Palacios, Maurie Balch, Macy L Sprunger, Matthew K Howard, Jeremy J Ryan, Jessica N Haines, Gary J Patti, Albert A Davis, Meredith E Jackrel
Parkinson's disease (PD) is closely linked to α-synuclein (α-syn) misfolding and accumulation in Lewy bodies. The PDZ serine protease HTRA1 degrades fibrillar tau, which is associated with Alzheimer's disease, and inactivating mutations to mitochondrial HTRA2 are implicated in PD. Here, we report that HTRA1 inhibits aggregation of α-syn as well as FUS and TDP-43, which are implicated in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. The protease domain of HTRA1 is necessary and sufficient for inhibiting aggregation, yet this activity is proteolytically-independent...
March 18, 2024: Nature Communications
https://read.qxmd.com/read/38499486/fus-reads-histone-h3k36me3-to-regulate-alternative-polyadenylation
#11
JOURNAL ARTICLE
Junqi Jia, Haonan Fan, Xinyi Wan, Yuan Fang, Zhuoning Li, Yin Tang, Yanjun Zhang, Jun Huang, Dong Fang
Complex organisms generate differential gene expression through the same set of DNA sequences in distinct cells. The communication between chromatin and RNA regulates cellular behavior in tissues. However, little is known about how chromatin, especially histone modifications, regulates RNA polyadenylation. In this study, we found that FUS was recruited to chromatin by H3K36me3 at gene bodies. The H3K36me3 recognition of FUS was mediated by the proline residues in the ZNF domain. After these proline residues were mutated or H3K36me3 was abolished, FUS dissociated from chromatin and bound more to RNA, resulting in an increase in polyadenylation sites far from stop codons genome-wide...
March 18, 2024: Nucleic Acids Research
https://read.qxmd.com/read/38498742/ultrasound-stimulation-attenuates-crs-induced-depressive-behavior-by-modulating-dopamine-release-in-the-prefrontal-cortex
#12
JOURNAL ARTICLE
Ling Wang, Sutong Wang, Weiyi Mo, Yaqing Li, Qing Yang, Yutao Tian, Chenguang Zheng, Jiajia Yang, Dong Ming
Depression is one of the most serious mental disorders affecting modern human life and is often caused by chronic stress. Dopamine system dysfunction is proposed to contribute to the pathophysiology of chronic stress, especially the ventral tegmental area (VTA) which mainly consists of dopaminergic neurons. Focused ultrasound stimulation (FUS) is a promising neuromodulation modality and multiple studies have demonstrated effective ultrasonic activation of cortical, subcortical, and related networks. However, the effects of FUS on the dopamine system and the potential link to chronic stress-induced depressive behaviors are relatively unknown...
March 19, 2024: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://read.qxmd.com/read/38496764/case-report-primary-pulmonary-low-grade-fibromyxoid-sarcoma-progressing-to-dedifferentiation-probably-due-to-tp53-driver-mutation
#13
Jiawen Zhang, Haisheng Fang, Xiaomei Zhu, Chenchen Yao, Qinhe Fan, Qixing Gong
Low Grade Fibromyxoid Sarcoma (LGFMS), a rare entity characterized by bland histologic features, typically affects deep soft tissues of the trunk and lower extremities. Rare cases have been reported arising from the viscera and few demonstrating morphology of high-grade dedifferentiation. Here we report a 39-year-old Chinese woman presenting with primary lung LGFMS, which metastasized to the pancreas five years after diagnosis and then relapsed ten years later as a mediastinum mass. Microscopically, the lung and pancreatic lumps shared similar classical features of LGFMS, composed of bland spindle-shaped cells with low mitotic activity...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38493058/neuroprotective-effects-of-niclosamide-on-disease-progression-via-inflammatory-pathways-modulation-in-sod1-g93a-and-fus-associated-amyotrophic-lateral-sclerosis-models
#14
JOURNAL ARTICLE
Martina Milani, Ilaria Della Valle, Simona Rossi, Paola Fabbrizio, Cassandra Margotta, Giovanni Nardo, Mauro Cozzolino, Nadia D'Ambrosi, Savina Apolloni
Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disease influenced by genetic, epigenetic, and environmental factors, resulting in dysfunction in cellular and molecular pathways. The limited efficacy of current treatments highlights the need for combination therapies targeting multiple aspects of the disease. Niclosamide, an anthelminthic drug listed as an essential medicine, has been repurposed in clinical trials for different diseases due to its anti-inflammatory and anti-fibrotic properties...
March 15, 2024: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://read.qxmd.com/read/38492239/insights-into-molecular-diversity-within-the-fus-ews-taf15-protein-family-unraveling-phase-separation-of-the-n-terminal-low-complexity-domain-from-rna-binding-protein-ews
#15
JOURNAL ARTICLE
Courtney N Johnson, Kandarp A Sojitra, Erich J Sohn, Alma K Moreno-Romero, Antoine Baudin, Xiaoping Xu, Jeetain Mittal, David S Libich
The FET protein family, comprising FUS, EWS, and TAF15, plays crucial roles in mRNA maturation, transcriptional regulation, and DNA damage response. Clinically, they are linked to Ewing family tumors and neurodegenerative diseases such as amyotrophic lateral sclerosis. The fusion protein EWS::FLI1, the causative mutation of Ewing sarcoma, arises from a genomic translocation that fuses a portion of the low-complexity domain (LCD) of EWS (EWSLCD ) with the DNA binding domain of the ETS transcription factor FLI1...
March 16, 2024: Journal of the American Chemical Society
https://read.qxmd.com/read/38488009/cytoplasmic-retention-of-the-dna-rna-binding-protein-fus-ameliorates-organ-fibrosis-in-mice
#16
JOURNAL ARTICLE
Manuel Chiusa, Youngmin A Lee, Ming-Zhi Zhang, Raymond C Harris, Taylor Sherrill, Volkhard Lindner, Craig R Brooks, Gang Yu, Agnes B Fogo, Charles R Flynn, Jozef Zienkiewicz, Jacek Hawiger, Roy Zent, Ambra Pozzi
Uncontrolled accumulation of extracellular matrix leads to tissue fibrosis and loss of organ function. We previously demonstrated in vitro that the DNA/RNA-binding protein fused in sarcoma (FUS) promotes fibrotic responses by translocating to the nucleus, where it initiates collagen gene transcription. However, it is still not known whether FUS is profibrotic in vivo and whether preventing its nuclear translocation might inhibit development of fibrosis following injury. We now demonstrate that levels of nuclear FUS are significantly increased in mouse models of kidney and liver fibrosis...
March 15, 2024: Journal of Clinical Investigation
https://read.qxmd.com/read/38481939/assessment-of-focused-ultrasound-stimulation-to-induce-peripheral-nerve-activity-and-potential-damage-in-vivo
#17
JOURNAL ARTICLE
Bruno Rodríguez-Meana, Eva Santos-Nogueira, Sònia Trujillo-Vázquez, Anette Jakob, Esther Udina, Marc Fournelle, Xavier Navarro
INTRODUCTION: Peripheral neuroprostheses are aimed to restore loss of sensory and motor functions by interfacing axons in the peripheral nerves. Most common interfaces in neuroprostheses are electrodes that establish electrical connection with peripheral axons. However, some challenges arise related to long-term functionality, durability, and body response. Recently, focused ultrasound stimulation (FUS) has emerged as a non-invasive approach to modulate the nervous system. However, it is controversial whether FUS can induce axon depolarization...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38480701/prmt5-is-an-actionable-therapeutic-target-in-cdk4-6-inhibitor-resistant-er-rb-deficient-breast-cancer
#18
JOURNAL ARTICLE
Chang-Ching Lin, Tsung-Cheng Chang, Yunguan Wang, Lei Guo, Yunpeng Gao, Emmanuel Bikorimana, Andrew Lemoff, Yisheng V Fang, He Zhang, Yanfeng Zhang, Dan Ye, Isabel Soria-Bretones, Alberto Servetto, Kyung-Min Lee, Xuemei Luo, Joseph J Otto, Hiroaki Akamatsu, Fabiana Napolitano, Ram Mani, David W Cescon, Lin Xu, Yang Xie, Joshua T Mendell, Ariella B Hanker, Carlos L Arteaga
CDK4/6 inhibitors (CDK4/6i) have improved survival of patients with estrogen receptor-positive (ER+) breast cancer. However, patients treated with CDK4/6i eventually develop drug resistance and progress. RB1 loss-of-function alterations confer resistance to CDK4/6i, but the optimal therapy for these patients is unclear. Through a genome-wide CRISPR screen, we identify protein arginine methyltransferase 5 (PRMT5) as a molecular vulnerability in ER+/RB1-knockout breast cancer cells. Inhibition of PRMT5 blocks the G1-to-S transition in the cell cycle independent of RB, leading to growth arrest in RB1-knockout cells...
March 13, 2024: Nature Communications
https://read.qxmd.com/read/38478631/cortical-hyperexcitability-in-mouse-models-and-patients-with-amyotrophic-lateral-sclerosis-is-linked-to-noradrenaline-deficiency
#19
JOURNAL ARTICLE
Jelena Scekic-Zahirovic, Cristina Benetton, Aurore Brunet, XiaoQian Ye, Evgeny Logunov, Vincent Douchamps, Salim Megat, Virginie Andry, Vanessa Wing Yin Kan, Geoffrey Stuart-Lopez, Johan Gilet, Simon J Guillot, Sylvie Dirrig-Grosch, Charlotte Gorin, Margaux Trombini, Stéphane Dieterle, Jérôme Sinniger, Mathieu Fischer, Frédérique René, Zeynep Gunes, Pascal Kessler, Luc Dupuis, Pierre-François Pradat, Yannick Goumon, Romain Goutagny, Véronique Marchand-Pauvert, Sabine Liebscher, Caroline Rouaux
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease, characterized by the death of upper (UMN) and lower motor neurons (LMN) in the motor cortex, brainstem, and spinal cord. Despite decades of research, ALS remains incurable, challenging to diagnose, and of extremely rapid progression. A unifying feature of sporadic and familial forms of ALS is cortical hyperexcitability, which precedes symptom onset, negatively correlates with survival, and is sufficient to trigger neurodegeneration in rodents...
March 13, 2024: Science Translational Medicine
https://read.qxmd.com/read/38476865/focused-ultrasound-thalamotomy-for-tremor-relief-in-atypical-parkisnsonism
#20
JOURNAL ARTICLE
Alon Sinai, Maria Nassar, Lev Shornikov, Marius Constantinescu, Menashe Zaaroor, Ilana Schlesinger
BACKGROUND: Magnetic resonance imaging (MRI)-guided focused ultrasound (FUS) VIM-thalamotomy has established efficacy and safety in tremor relief in patients with essential tremor and Parkinson's disease. The efficacy and safety in patients with atypical parkinsonism have not been reported. OBJECTIVE: To report on the efficacy and safety of FUS VIM-thalamotomy in 8 patients with parkinsonism, multiple system atrophy-Parkinsonian type (MSA-P) ( n  = 5), and dementia with Lewy bodies (DLB) ( n  = 3)...
2024: Parkinson's Disease
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