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https://www.readbyqxmd.com/read/28292261/genome-wide-analysis-of-a-avirulent-and-reveal-the-strain-induces-pro-tective-immunity-against-challenge-with-virulent-streptococcus-suis-serotype-2
#1
Jing Wang, Youjun Feng, Changjun Wang, Feng Zheng, Bachar Hassan, Liming Zhi, Wenjuan Li, Yi Yao, Elaine He, Shibo Jiang, Jiaqi Tang
BACKGROUND: It was previously reported in China that two recent large-scale outbreaks of Streptococcus suis serotype 2 (S. suis 2) infections in human were caused by two highly virulent S. suis 2 strains, from which a novel genomic island (GEI), associated with disease onset and progression and designated 89 K, was identified. Here, an avirulent strain, 05HAS68, was isolated from a clinically healthy pig. RESULTS: By comparing the genomes of this avirulent strain with virulent strains, it was found that massive genomic rearrangements occurred, resulting in alterations in gene expression that caused enormous single gene gain and loss...
March 14, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28130395/weight-trajectories-of-israeli-pediatric-cancer-survivors
#2
Marilyn Stern, Eytan Bachar, Eyal Ronen Ackerman, Diana Rancourt, Omer Bonne, Michael Weintraub
OBJECTIVE : Cross-national replication of the high rates of overweight/obesity among U.S. pediatric cancer survivors (PCS) is limited. Predictors of weight trajectories of Israeli PCS were examined from diagnosis and end of active cancer treatment to 3 years posttreatment. METHODS : World Health Organization-derived body mass index (z-BMI) values were calculated at each time point from medical records of 135 Israeli PCS (M diagnosis age = 11.4). A three-section piecewise multilevel model including age, ethnicity, gender, treatment length, and diagnosis as predictors was used to estimate z-BMI trajectories...
January 27, 2017: Journal of Pediatric Psychology
https://www.readbyqxmd.com/read/28027285/acute-rhinosinusitis-in-immunosuppressed-children-diagnostic-and-therapeutic-management
#3
Amit Ritter, Salvador Fischer, Eitan Yaniv, Tuvia Hadar, Ethan Soudry, Daniel Shai, Dror Gilony, Gideon Bachar
BACKGROUND: Immunosuppressive therapy places pediatric patients at risk of developing life-threatening sinonasal infections. Diagnosis and treatment are challenging owing to nonspecific signs and symptoms. The aim of this study was to present our department's experience with the surgical management of acute rhinosinusitis in immunosuppressed children. METHODS: The records of all children with a hematologic or oncologic disease who underwent endoscopic sinus surgery (ESS) for acute rhinosinusitis from January 2005 to May 2014 were reviewed...
April 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27884923/clinical-metrics-in-emergency-medicine-the-shock-index-and-the-probability-of-hospital-admission-and-inpatient-mortality
#4
Kamna S Balhara, Yu-Hsiang Hsieh, Bachar Hamade, Ryan Circh, Gabor D Kelen, Jamil D Bayram
STUDY OBJECTIVES: The shock index (SI), defined as the ratio of HR to systolic BP, has been studied as an alternative prognostic tool to traditional vital signs in specific disease states and subgroups of patients. However, literature regarding its utility in the general ED population is lacking. Our main objective was to determine the probability of admission and inpatient mortality based on the first measured SI at initial presentation in the general adult ED population in our tertiary care centre...
February 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/27819657/culture-of-previously-uncultured-members-of-the-human-gut-microbiota-by-culturomics
#5
Jean-Christophe Lagier, Saber Khelaifia, Maryam Tidjani Alou, Sokhna Ndongo, Niokhor Dione, Perrine Hugon, Aurelia Caputo, Frédéric Cadoret, Sory Ibrahima Traore, El Hadji Seck, Gregory Dubourg, Guillaume Durand, Gaël Mourembou, Elodie Guilhot, Amadou Togo, Sara Bellali, Dipankar Bachar, Nadim Cassir, Fadi Bittar, Jérémy Delerce, Morgane Mailhe, Davide Ricaboni, Melhem Bilen, Nicole Prisca Makaya Dangui Nieko, Ndeye Mery Dia Badiane, Camille Valles, Donia Mouelhi, Khoudia Diop, Matthieu Million, Didier Musso, Jônatas Abrahão, Esam Ibraheem Azhar, Fehmida Bibi, Muhammad Yasir, Aldiouma Diallo, Cheikh Sokhna, Felix Djossou, Véronique Vitton, Catherine Robert, Jean Marc Rolain, Bernard La Scola, Pierre-Edouard Fournier, Anthony Levasseur, Didier Raoult
Metagenomics revolutionized the understanding of the relations among the human microbiome, health and diseases, but generated a countless number of sequences that have not been assigned to a known microorganism(1). The pure culture of prokaryotes, neglected in recent decades, remains essential to elucidating the role of these organisms(2). We recently introduced microbial culturomics, a culturing approach that uses multiple culture conditions and matrix-assisted laser desorption/ionization-time of flight and 16S rRNA for identification(2)...
November 7, 2016: Nature Microbiology
https://www.readbyqxmd.com/read/27792831/prognostic-factors-in-metastatic-cutaneous-squamous-cell-carcinoma-of-the-head-and-neck
#6
Gideon Bachar, Aviram Mizrachi, Naomi Rabinovics, Dan Guttman, Thomas Shpitzer, Dean Ad-El, Tuvia Hadar
Metastatic cutaneous squamous cell carcinoma (SCC) of the head and neck poses a significant therapeutic challenge due to its aggressive biologic behavior. We conducted a retrospective study of 71 patients-58 men and 13 women, aged 28 to 88 years (mean: 71)-who had been treated at our university-affiliated tertiary care medical center for metastatic cutaneous SCC over a 15-year period. In addition to demographic data, we compiled and analyzed information on tumor characteristics, the site and extent of metastasis, treatment, follow-up, and outcome...
October 2016: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/27696726/parathyroid-adenoma-a-comprehensive-biochemical-and-histological-correlative-study
#7
S Stern, A Mizrachi, Y Strenov, A Knaanie, C Benbassat, T Shpitzer, G Bachar
OBJECTIVE: To investigate the controversial relationship between preoperative calcium and parathyroid hormone levels and the dimensions and histological features of parathyroid adenoma in patients with primary hyperparathyroidism. STUDY DESIGN: Historical cohort. SETTING: Tertiary medical centre. SUBJECTS AND METHODS: Clinical and tumour-related data were collected from the medical files of all patients who underwent parathyroidectomy for primary hyperparathyroidism in 1996-2012...
October 3, 2016: Clinical Otolaryngology
https://www.readbyqxmd.com/read/27680410/radiological-evaluation-of-artificial-stone-silicosis-outbreak-emphasizing-findings-in-lung-transplant-recipients
#8
Ahuva Grubstein, Osnat Shtraichman, Elizabeth Fireman, Gil N Bachar, Noa Noach-Ophir, Mordechai R Kramer
OBJECTIVE: The aim of this study was to describe the computed tomography (CT) findings and correlate pulmonary function tests (PFTs) of silicosis patients with emphasis on the findings in lung transplantation (LTX) recipients. METHODS: We studied the chest CT scans from 82 marble workers exposed to artificial stone dust and who had a diagnosis of silicosis, of whom 13 patients underwent LTX. Silicosis-associated findings were graded and correlated to concomitant PFT...
November 2016: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/27636541/contraceptive-behaviour-of-christian-and-muslim-teenagers-at-the-time-of-abortion-and-post-abortion-in-thrace-greece
#9
Panagiotis Tsikouras, Zacharoula Koukouli, Nikolaos Psarros, Bachar Manav, Nikolaos Tsagias, Georgios Galazios
OBJECTIVES: The aims of the study were to compare the contraceptive behaviour of Christian and Muslim adolescents who had an abortion in Thrace, Greece, and to examine whether extensive contraceptive counselling at the time of abortion modified their subsequent contraceptive practices. METHODS: Adolescents, aged 14-19 years, who had undergone an elective abortion in our department, were included in a prospective 12-year study. Extensive contraceptive counselling was offered before discharge from the hospital...
December 2016: European Journal of Contraception & Reproductive Health Care
https://www.readbyqxmd.com/read/27602107/distinctive-pattern-of-let-7-family-micrornas-in-aggressive-carcinoma-of-the-oral-tongue-in-young-patients
#10
Ohad Hilly, Nir Pillar, Sagit Stern, Yulia Strenov, Gideon Bachar, Noam Shomron, Thomas Shpitzer
Oral cavity squamous cell carcinoma may be more aggressive at presentation and recurrence in young patients compared with older patients. Dysregulation of microRNAs (miRNAs or miRs) has been associated with the development and prognosis of oral cavity cancer. The present study investigated miRNA expression in carcinoma of the oral tongue in young patients. miRNA expression profiles were evaluated in formalin-fixed, paraffin-embedded samples of tumor and normal mucosa from 12 patients aged <30 years old with squamous cell carcinoma of the tongue...
September 2016: Oncology Letters
https://www.readbyqxmd.com/read/27578328/gut-microbiome-and-dietary-patterns-in-different-saudi-populations-and-monkeys
#11
Emmanouil Angelakis, Muhammad Yasir, Dipankar Bachar, Esam I Azhar, Jean-Christophe Lagier, Fehmida Bibi, Asif A Jiman-Fatani, Maha Alawi, Marwan A Bakarman, Catherine Robert, Didier Raoult
Host genetics, environment, lifestyle and proximity between hosts strongly influence the composition of the gut microbiome. To investigate the association of dietary variables with the gut microbiota, we used 16S rDNA sequencing to test the fecal microbiome of Bedouins and urban Saudis and we compared it to the gut microbiome of baboons living in close contact with Bedouins and eating their leftovers. We also analyzed fermented dairy products commonly consumed by Bedouins in order to investigate their impact on the gut microbiome of this population...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27556178/phase-ii-organ-preservation-trial-concurrent-cisplatin-and-radiotherapy-for-advanced-laryngeal-cancer-after-response-to-docetaxel-cisplatin-and-5-fluorouracil-based-induction-chemotherapy
#12
Aron Popovtzer, Hanna Burnstein, Salomon Stemmer, Dror Limon, Ohad Hili, Gideon Bachar, Vladamir Sopov, Raphael Feinmesser, David Groshar, Jacob Shvero
BACKGROUND: The optimal treatment for locally advanced laryngeal cancer remains controversial. The purpose of this trial was to determine if the response to induction chemotherapy could select patients for organ preservation protocols, and improve larynx-preservation rates without compromising overall survival (OS). METHODS: The cohort comprised 12 patients with T3 disease and 14 with T4. Induction chemotherapy consisted of docetaxel, cisplatin, and 5-fluorouracil (TPF)...
February 2017: Head & Neck
https://www.readbyqxmd.com/read/27547442/gut-microbiota-associated-with-hiv-infection-is-significantly-enriched-in-bacteria-tolerant-to-oxygen
#13
Grégory Dubourg, Jean-Christophe Lagier, Sophie Hüe, Mathieu Surenaud, Dipankar Bachar, Catherine Robert, Caroline Michelle, Isabelle Ravaux, Saadia Mokhtari, Matthieu Million, Andreas Stein, Philippe Brouqui, Yves Levy, Didier Raoult
OBJECTIVES: Gut microbiota modifications occurring during HIV infection have recently been associated with inflammation and microbial translocation. However, discrepancies between studies justified a comprehensive analysis performed on a large sample size. DESIGN AND METHODS: In a case-control study, next-generation sequencing of the 16S rRNA gene was applied to the faecal microbiota of 31 HIV-infected patients, of whom 18 were treated with antiretroviral treatment (ART), compared with 27 healthy controls...
2016: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/27535789/ph-drop-impacts-differentially-skin-and-gut-microbiota-of-the-amazonian-fish-tambaqui-colossoma-macropomum
#14
François-Étienne Sylvain, Bachar Cheaib, Martin Llewellyn, Tiago Gabriel Correia, Daniel Barros Fagundes, Adalberto Luis Val, Nicolas Derome
Aquatic organisms are increasingly exposed to lowering of environmental pH due to anthropogenic pressure (e.g. acid rain, acid mine drainages). Such acute variations trigger imbalance of fish-associated microbiota, which in turn favour opportunistic diseases. We used the tambaqui (Colossoma macropomum), an Amazonian fish tolerant to significant pH variation in its natural environment, to assess the response of fish endogenous microbiota to acute short-term acid stress. We exposed 36 specimens of tambaquis to acidic water (pH 4...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27533926/neuromonitoring-during-adult-cardiac-surgery
#15
Anna K Kowalczyk, Bradlee J Bachar, Hong Liu
No abstract text is available yet for this article.
May 2016: Journal of Biomedical Research
https://www.readbyqxmd.com/read/27507221/radiotherapy-in-early-stage-tongue-squamous-cell-carcinoma-with-minor-adverse-features
#16
Orna Katz, Yuval Nachalon, Ohad Hilly, Thomas Shpitzer, Gideon Bachar, Dror Limon, Aron Popovtzer
BACKGROUND: Treatment for early-stage tongue squamous cell carcinoma (SCC) is usually surgery alone. There is ambiguity regarding the impact of minor adverse features (MAFs) on outcome and the role of postoperative radiotherapy (PORT) in tongue SCC. METHODS: A retrospective analysis was performed on 48 patients diagnosed with tongue SCC treated in our center. Patients with MAFs received adjuvant PORT. Disease outcome in patients with MAFs, and the effect of PORT were analyzed using the Kaplan-Meier method and log-rank test...
January 2017: Head & Neck
https://www.readbyqxmd.com/read/27426658/chronic-kidney-disease-as-major-determinant-of-the-renal-risk-related-to-on-pump-cardiac-surgery-a-single-center-cohort-study
#17
Jean-Michel Hougardy, Perrine Revercez, Aline Pourcelet, Bachar El Oumeiri, Judith Racapé, Alain Le Moine, Frédéric Vanden Eynden, Daniel De Backer
BACKGROUND: Cardiac surgery-associated acute kidney injury (CSA-AKI) is a common complication and is associated with the poorest outcomes. Therefore, early prediction of CSA-AKI remains a major issue. Severity scores such as the STS score could estimate the risk of AKI preoperatively. The main objective of this study was to evaluate the risk factors of on-pump CSA-AKI and to assess the performance of the STS score in order to predict CSA-AKI. PATIENTS: We identified 252 patients with on-pump cardiac surgery, and the STS score was defined retrospectively...
August 2016: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/27292600/varicella-zoster-virus-encephalitis-in-an-immunocompetent-patient-without-a-rash
#18
Candice D Jordan, Frederick Korley, Bachar Hamade
No abstract text is available yet for this article.
November 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27273940/cervical-cancer-screening-diagnosis-and-staging
#19
REVIEW
Panagiotis Tsikouras, Stefanos Zervoudis, Bachar Manav, Eirini Tomara, George Iatrakis, Constantinos Romanidis, Anastasia Bothou, George Galazios
Purpose: Despite the widespread screening programs, cervical cancer remains the third most common cancer in developing countries. Based on the implementation of cervical screening programs with the referred adoption of improved screening methods in cervical cytology with the knowledge of the important role of the human papilloma virus (HPV) it's incidence is decreased in the developed world. Even if cervical HPV infection is incredibly common, cervical cancer is relatively rare. Depending on the rarity of invasive disease and the improvement of detection of pre-cancerous lesions due to the participation in screening programs, the goal of screening is to detect the cervical lesions early in order to be treated before cancer is developed...
March 2016: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/27271723/radiographic-templating-of-total-hip-arthroplasty-for-femoral-neck-fractures
#20
Dror Lakstein, Ira Bachar, Ronen Debi, Omri Lubovsky, Ornit Cohen, Zachary Tan, Ehud Atoun
PURPOSE: The purpose of this study was to evaluate the use of pre-operative digital templating to minimize complications including limb length discrepancy (LLD), intraoperative fractures and early dislocations in patients with intracapsular femoral neck fractures. METHODS: We retrospectively compared 23 patients undergoing total hip arthroplasty (THA) for intracapsular femoral fractures with pre-operative digital templating and 48 patients without templating. RESULTS: The mean post-operative LLD was significantly lower in patients who had pre-operative templating than in the control group (6...
June 7, 2016: International Orthopaedics
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