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https://www.readbyqxmd.com/read/29783950/effects-of-the-cardiac-myosin-activator-omecamtiv-mecarbil-on-severe-chronic-aortic-regurgitation-in-wistar-rats
#1
Bachar El-Oumeiri, Kathleen Mc Entee, Filippo Annoni, Antoine Herpain, Frédéric Vanden Eynden, Pascal Jespers, Guido Van Nooten, Philippe van de Borne
BACKGROUND: Aortic regurgitation (AR) is a valvular disease that can lead to systolic heart failure. Treatment options besides cardiac surgery are limited and consequently severe AR is associated with higher mortality and morbidity when not operated. In this investigation, we examined the effects of a novel cardiac myosin activator, Omecamtiv-mecarbil (OM), in rats with chronic severe AR. METHODS: AR was created by retrograde puncture of the aortic valve leaflets in 20 adults Wistar rats...
May 21, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29774016/taxon-function-decoupling-as-an-adaptive-signature-of-lake-microbial-metacommunities-under-a-chronic-polymetallic-pollution-gradient
#2
Bachar Cheaib, Malo Le Boulch, Pierre-Luc Mercier, Nicolas Derome
Adaptation of microbial communities to anthropogenic stressors can lead to reductions in microbial diversity and disequilibrium of ecosystem services. Such adaptation can change the molecular signatures of communities with differences in taxonomic and functional composition. Understanding the relationship between taxonomic and functional variation remains a critical issue in microbial ecology. Here, we assessed the taxonomic and functional diversity of a lake metacommunity system along a polymetallic pollution gradient caused by 60 years of chronic exposure to acid mine drainage (AMD)...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29757457/the-role-of-adjuvant-treatment-in-early-stage-oral-cavity-squamous-cell-carcinoma-an-international-collaborative-study
#3
Eran Fridman, Shorook Na'ara, Jaiprakash Agarwal, Moran Amit, Gideon Bachar, Andrea Bolzoni Villaret, Jose Brandao, Claudio R Cernea, Pankaj Chaturvedi, Jonathan Clark, Ardalan Ebrahimi, Dan M Fliss, Sashikanth Jonnalagadda, Hugo F Kohler, Luiz P Kowalski, Matthias Kreppel, Chun-Ta Liao, Snehal G Patel, Raj P Patel, K Thomas Robbins, Jatin P Shah, Thomas Shpitzer, Tzu-Chen Yen, Joachim E Zöller, Ziv Gil
BACKGROUND: Up to half of patients with oral cavity squamous cell carcinoma (OCSCC) have stage I to II disease. When adequate resection is attained, no further treatment is needed; however, re-resection or radiotherapy may be indicated for patients with positive or close margins. This multicenter study evaluated the outcomes and role of adjuvant treatment in patients with stage I to II OCSCC. METHODS: Overall survival (OS), disease-specific survival, local-free survival, and disease-free survival rates were calculated with Kaplan-Meier analysis...
May 14, 2018: Cancer
https://www.readbyqxmd.com/read/29734907/omega-%C3%AE-pulley-plasty-for-surgical-management-of-dequervain-s-disease
#4
Joseph Bakhach, Bachar Chaya, Nazareth Papazian
BACKGROUND: DeQuervain tenosynovitis, refractory to medical conservative treatment, has been traditionally treated by a simple division of the pulley, a procedure associated with several complications. Many authors attempted to prevent these complications by describing techniques of pulley reconstruction after its release necessitating suturing the different flaps and subsequently promoting extensor tendons adhesions. The authors present an alternative procedure for the first extensor compartment pulley decompression: "Omegaplasty"...
June 2018: Journal of Hand Surgery Asian-Pacific Volume
https://www.readbyqxmd.com/read/29728730/awake-tracheostomy-indications-complications-and-outcome
#5
Doron Sagiv, Yuval Nachalon, Jobran Mansour, Eran Glikson, Eran E Alon, Arkadi Yakirevitch, Gideon Bachar, Michael Wolf, Adi Primov-Fever
BACKGROUND: Awake tracheostomy (AT) is aimed at securing the airway of patients with upper airway obstruction when other means are not feasible or have failed. Reports on AT in the literature are scarce. The goal of this study was to review our experience with the indications, complications and outcome of AT. METHODS: A retrospective chart review was conducted on all ATs performed between 2010 and 2016 in two university-affiliated, tertiary medical centers. Data on demographics, indications, techniques, urgency and postoperative complications were retrieved from the medical charts...
May 4, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29673847/challenges-in-the-management-of-type-2-diabetes-among-native-women-in-the-united-arab-emirates
#6
Walaa Abuelmagd, Bachar Afandi, Helle Håkonsen, Seham Khmidi, Else-Lydia Toverud
AIM: To investigate type 2 diabetes mellitus (T2DM) management in native female patients in the United Arab Emirates (UAE). METHODS: Ninety women from the outpatient diabetes clinic at Tawam Hospital, UAE, were interviewed face-to-face using a structured questionnaire. Glycated hemoglobin (HbA1c), blood pressure, lipid panel, weight and body mass index (BMI) were extracted from medical records. RESULTS: Mean age was 57.5 (SD:12.7) years. Forty-five participants (50...
April 16, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29576820/the-emergency-department-crash-cart-a-systematic-review-and-suggested-contents
#7
REVIEW
Gabrielle A Jacquet, Bachar Hamade, Karim A Diab, Rasha Sawaya, Gilbert Abou Dagher, Eveline Hitti, Jamil D Bayram
BACKGROUND: As the field of Emergency Medicine grows worldwide, the importance of an Emergency Department Crash Cart (EDCC) has long been recognized. Yet, there is paucity of relevant peer-reviewed literature specifically discussing EDCCs or proposing detailed features for an EDCC suitable for both adult and pediatric patients. METHODS: The authors performed a systematic review of EDCC-specific literature indexed in Pubmed and Embase on December 20, 2016. In addition, the authors reviewed the 2015 American Heart Association (AHA) guidelines for cardiopulmonary resuscitation and emergency cardiovascular care, the 2015 European Resuscitation Council (ERC) guidelines for resuscitation, and the 2013 American College of Surgeons (ACS) Advanced Trauma Life Support (ATLS) 9th edition...
2018: World Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29557834/anterior-chamber-angle-tissue-as-an-incidental-optical-coherence-tomography-finding-in-a-large-healthy-caucasian-child-population
#8
José Ignacio Fernández-Vigo, Lucía De-Pablo-Gómez-de-Liaño, Bachar Kudsieh, Cristina Fernández-Vigo, José Ángel Fernández-Vigo, Julián García-Feijóo
PURPOSE: To describe the presence of anterior chamber angle (ACA) tissue as an incidental optical coherence tomography (OCT) finding in healthy children. METHODS: For this cross-sectional study, we reviewed Fourier domain OCT images obtained in 422 children as candidates for inclusion in a prior study who visited our clinic for a routine vision test. The presence of angle tissue was assessed in the nasal and temporal quadrants. On tomographies showing angle tissue, several measurements were made including ACA width and trabecular meshwork (TM) length and size...
March 19, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29527849/how-prevalent-is-hydronephrosis-secondary-to-acute-appendicitis-a-cross-sectional-study
#9
Hanan Goldberg, Gil N Bachar, Riad Majadla, Ofer Yossepowitch, Jack Baniel, Edward Ram
BACKGROUND: Right hydronephrosis secondary to acute appendicitis is an under-reported phenomenon with only several case reports published. OBJECTIVES: To assess the incidence of this phenomenon in our database of patients diagnosed with acute appendicitis. METHODS: Data were collected on 1092 patients who underwent surgery due to acute appendicitis between 2003 and 2007 in our tertiary medical center. The data entailed demographic, surgical, and hospitalization parameters including ultrasound or computed tomography examinations and presence of right hydronephrosis prior to surgery...
March 2018: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29520919/predictors-of-weight-reduction-and-maintenance-in-a-large-cohort-of-overweight-and-obese-adults-in-a-community-setting
#10
Adina Bachar, Gregory Livshits, Ruth Birk
AIM: In overweight/obese individuals, modest 5% weight loss and its maintenance promotes health; however, it is challenging and typically unachievable, especially in community settings. Established predictors of weight loss outcome in a community setting are lacking, hindering the development of practical interventions and prevention tools. Our aim was to identify predictors associated with 5% weight reduction (initial 6 months) and maintenance (1 year) in overweight and obese adults undergoing weight reduction treatment, free of charge, in a community setting...
March 8, 2018: Nutrition & Dietetics: the Journal of the Dietitians Association of Australia
https://www.readbyqxmd.com/read/29506045/impact-of-minimal-extra-thyroid-extension-in-differentiated-thyroid-cancer-systematic-review-and-meta-analysis
#11
Talia Diker-Cohen, Dania Hirsch, Ilan Shimon, Gideon Bachar, Amit Akirov, Hadar Duskin-Bitan, Eyal Robenshtok
Background: Minimal extra-thyroid extension (mETE) in differentiated thyroid cancer (DTC) patients was defined as an intermediate risk feature in the 2015 American Thyroid Association guidelines. However, controversy persists as several studies suggested mETE has little effect on disease outcome. Objective: To assess the impact of mETE on DTC patients' outcome. Methods: Meta-analysis of controlled trials comparing DTC patients with and without mETE...
March 1, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29499138/the-ubiquitin-e3-e4-ligase-ube4a-adjusts-protein-ubiquitylation-and-accumulation-at-sites-of-dna-damage-facilitating-double-strand-break-repair
#12
Keren Baranes-Bachar, Adva Levy-Barda, Judith Oehler, Dylan A Reid, Isabel Soria-Bretones, Ty C Voss, Dudley Chung, Yoon Park, Chao Liu, Jong-Bok Yoon, Wei Li, Graham Dellaire, Tom Misteli, Pablo Huertas, Eli Rothenberg, Kristijan Ramadan, Yael Ziv, Yosef Shiloh
Double-strand breaks (DSBs) are critical DNA lesions that robustly activate the elaborate DNA damage response (DDR) network. We identified a critical player in DDR fine-tuning: the E3/E4 ubiquitin ligase UBE4A. UBE4A's recruitment to sites of DNA damage is dependent on primary E3 ligases in the DDR and promotes enhancement and sustainment of K48- and K63-linked ubiquitin chains at these sites. This step is required for timely recruitment of the RAP80 and BRCA1 proteins and proper organization of RAP80- and BRCA1-associated protein complexes at DSB sites...
March 1, 2018: Molecular Cell
https://www.readbyqxmd.com/read/29491015/clostridium-scindens-is-present-in-the-gut-microbiota-during-clostridium-difficile-infection-a-metagenomic-and-culturomic-analysis
#13
LETTER
Sophie Amrane, Dipankar Bachar, Jean Christophe Lagier, Didier Raoult
No abstract text is available yet for this article.
May 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29462872/ten-years-of-experience-in-contraception-options-for-teenagers-in-a-family-planning-center-in-thrace-and-review-of-the-literature
#14
Panagiotis Tsikouras, Dorelia Deuteraiou, Anastasia Bothou, Xanthi Anthoulaki, Anna Chalkidou, Eleftherios Chatzimichael, Fotini Gaitatzi, Bachar Manav, Zacharoula Koukoul, Stefanos Zervoudis, Grigorios Trypsianis, George Galazios
Abstract : Introduction : The goal of our study was to investigate and evaluate the contraceptive behavior in teenagers from our family planning centre that services two different religious and socioeconomic populations living in the Thrace area. Methods : During the last 10 years 115 Christian Orthodox (group A) and 53 Muslim teenagers (group B) were enrolled in our retrospective study. Contraceptive practice attitudes were assessed by a questionnaire. Religion, demographics, socio-economic characteristics were key factors used to discuss contraception and avoid unplanned pregnancy in each group and to compare with the contraceptive method used...
February 15, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29402183/temporal-trends-in-the-presentation-treatment-and-outcome-of-medullary-thyroid-carcinoma-an-israeli-multicenter-study
#15
Dania Hirsch, Orit Twito, Sigal Levy, Gideon Bachar, Eyal Robenshtok, David J Gross, Haggi Mazeh, Carlos Benbassat, Simona Grozinsky-Glasberg
BACKGROUND: The widespread use of neck sonography in recent years has led to a dramatic increase in the detection of thyroid cancer, accompanied by changes in the clinicopathologic features of the disease. However, small papillary carcinomas account for the bulk of this increase, while little is known about temporal changes in medullary thyroid carcinoma (MTC). The aim of this study was to evaluate trends in the presentation, treatment, and outcome of MTC. METHODS: Patients treated for MTC at four medical centers in Israel were divided into three groups by year of diagnosis: 19811995 (period A), 1996-2005 (period B), and 2006-2016 (period C)...
March 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29398645/the-potency-of-lemon-citrus-limon-l-essential-oil-to-control-some-fungal-diseases-of-grapevine-wood
#16
Faiza Ammad, Oussama Moumen, Abdelbaset Gasem, Salam Othmane, Kato-Noguchi Hisashi, Bachar Zebib, Othmane Merah
This study aimed to evaluate the in vitro antifungal activity (AA) of the essential oil (EO) of lemon (Citrus limon L.) against three pathogenic fungi attacking grapevine wood. The composition of the EO was also studied. Ten volatile components were identified by gas chromatography-mass spectrometry. The results showed that the EO consists of volatile components where monoterpene hydrocarbons are the most abundant ones. Four major components were identified, which represent 99.9% of the total EO (limonene, neral, β-pinene, and γ-terpinene)...
February 2018: Comptes Rendus Biologies
https://www.readbyqxmd.com/read/29327191/iron-impregnated-zeolite-catalyst-for-efficient-removal-of-micropollutants-at-very-low-concentration-from-meurthe-river
#17
Hawraa Ayoub, Thibault Roques-Carmes, Olivier Potier, Bachar Koubaissy, Steve Pontvianne, Audrey Lenouvel, Cédric Guignard, Emmanuel Mousset, Hélène Poirot, Joumana Toufaily, Tayssir Hamieh
In this paper, for the first time, faujasite Y zeolite impregnated with iron (III) was employed as a catalyst to remove a real cocktail of micropollutants inside real water samples from the Meurthe river by the means of the heterogeneous photo-Fenton process. The catalyst was prepared by the wet impregnation method using iron (III) nitrate nonahydrate as iron precursor. First, an optimization of the process parameters was conducted using phenol as model macro-pollutant. The hydrogen peroxide concentration, the light wavelength (UV and visible) and intensity, the iron loading immobilized, as well as the pH of the solution were investigated...
January 11, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29299518/an-updated-review-of-pediatric-drug-induced-sleep-endoscopy
#18
REVIEW
Lyndy J Wilcox, Mathieu Bergeron, Saranya Reghunathan, Stacey L Ishman
Objectives: Drug-induced sleep endoscopy (DISE) involves assessment of the upper airway using a flexible endoscope while patients are in a pharmacologically-induced sleep-like state. The aim of this article is to review the current literature regarding the role of DISE in children with obstructive sleep apnea (OSA). The indications, typical anesthetic protocol, comparison to other diagnostic modalities, scoring systems, and outcomes are discussed. Methods: A comprehensive review of literature regarding pediatric DISE up through May 2017 was performed...
December 2017: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/29296864/immune-tolerance-induction-by-nonmyeloablative-haploidentical-hsct-combining-t-cell-depletion-and-posttransplant-cyclophosphamide
#19
Franco Aversa, Esther Bachar-Lustig, Noga Or-Geva, Lucia Prezioso, Sabrina Bonomini, Ilenia Manfra, Alessandro Monti, Chiara Schifano, Yael Zlotnikov-Klionsky, Massimo F Martelli, Gabriella Sammarelli, Maria Sassi, Maurizio Soli, Silvia Giuliodori, Magda Benecchi, Nicola Giuliani, Frank Lohr, Silvia Pratissoli, Yair Reisner
The establishment of safe approaches to attain durable donor-type chimerism and immune tolerance toward donor antigens represents a major challenge in transplantation biology. Haploidentical hematopoietic stem cell transplantation (HSCT) is currently used for cancer therapy either as a T-cell-depleted megadose HSCT following myeloablative conditioning or with T-cell-replete HSCT following nonmyeloablative conditioning (NMAC) and high-dose posttransplant cyclophosphamide (PTCY). The latter approach suffers from a significant rate of chronic graft-versus-host disease (GVHD), despite prolonged immunosuppression...
November 14, 2017: Blood Advances
https://www.readbyqxmd.com/read/29277498/retinal-astrocytoma-regression-in-tuberous-sclerosis-patients-treated-with-everolimus
#20
Anat Bachar Zipori, Nasrin N Tehrani, Asim Ali
Everolimus is an inhibitor of the mammalian target of rapamycin (mTOR) that has been approved by the US Food and Drug Administration for the treatment of subependymal giant cell astrocytoma (SEGA) in patients with tuberous sclerosis complex (TSC). Retinal hamartomas, which are one of the major diagnostic features of TSC, tend to remain stable or gradually progress in the natural history of the disease. We report 2 patients with TSC treated with everolimus for SEGA in whom fundus photographs and spectral domain optical coherence tomography demonstrated regression of previously documented multiple retinal hamartomas in all 4 eyes...
February 2018: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
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