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https://www.readbyqxmd.com/read/28806784/structural-analysis-of-p-falciparum-kahrp-and-pfemp1-complexes-with-host-erythrocyte-spectrin-suggests-a-model-for-cytoadherent-knob-protrusions
#1
Erin E Cutts, Niklas Laasch, Dirk M Reiter, Raphael Trenker, Leanne M Slater, Phillip J Stansfeld, Ioannis Vakonakis
Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) and Knob-associated Histidine-rich Protein (KAHRP) are directly linked to malaria pathology. PfEMP1 and KAHRP cluster on protrusions (knobs) on the P. falciparum-infected erythrocyte surface and enable pathogenic cytoadherence of infected erythrocytes to the host microvasculature, leading to restricted blood flow, oxygen deprivation and damage of tissues. Here we characterize the interactions of PfEMP1 and KAHRP with host erythrocyte spectrin using biophysical, structural and computational approaches...
August 14, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28802108/do-environmental-factors-affect-male-fathead-minnow-pimephales-promelas-response-to-estrone-part-2-temperature-and-food-availability
#2
N W Shappell, D J Feifarek, D C Rearick, S E Bartell, H L Schoenfuss
Fish are subject to constantly changing environmental conditions and food availability, factors that may impact their response to endocrine disruptors (EDs). This may, in part, explain outcome discrepancies between field studies and laboratory exposures to EDs. This study assessed whether standard laboratory conditions for fish exposures adequately represent effects of ED exposure at two environmentally realistic temperatures. The impact of temperature and food availability on male fathead minnow response to estrone (E1) exposure was studied in two experiments (3×2×2 factorial design) with three E1 concentrations (range 0-135ng/L); two temperatures (18°C and 26°C, the latter the prescribed laboratory temperature), and two feeding treatments (full fed vs...
August 9, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28772037/cardiac-and-peripheral-autonomic-control-in-restrictive-cardiomyopathy
#3
Ana Luiza C Sayegh, Marcelo R Dos Santos, Adriana O Sarmento, Francis R de Souza, Vera M C Salemi, Viviane T Hotta, Akothirene Cristhina D B Marques, Heidrum H Krämer, Ivani C Trombetta, Charles Mady, Maria Janieire de Nazaré Nunes Alves
AIMS: Autonomic dysfunction determines the advance of dilated cardiomyopathy (DCM) and is related to poor outcomes. However, this autonomic imbalance is unknown in patients with restrictive cardiomyopathy (RCM) even though they have similar symptoms and poor quality of life as DCM patients have. The aim of this study was to evaluate if autonomic and neurovascular controls were altered in RCM patients. METHODS AND RESULTS: Fifteen RCM patients, 10 DCM patients, and 10 healthy subjects were evaluated...
August 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/28770207/aberrant-cerebral-blood-flow-in-response-to-hunger-and-satiety-in-women-remitted-from-anorexia-nervosa
#4
Christina E Wierenga, Amanda Bischoff-Grethe, Grace Rasmusson, Ursula F Bailer, Laura A Berner, Thomas T Liu, Walter H Kaye
The etiology of pathological eating in anorexia nervosa (AN) remains poorly understood. Cerebral blood flow (CBF) is an indirect marker of neuronal function. In healthy adults, fasting increases CBF, reflecting increased delivery of oxygen and glucose to support brain metabolism. This study investigated whether women remitted from restricting-type AN (RAN) have altered CBF in response to hunger that may indicate homeostatic dysregulation contributing to their ability to restrict food. We compared resting CBF measured with pulsed arterial spin labeling in 21 RAN and 16 healthy comparison women (CW) when hungry (after a 16-h fast) and after a meal...
2017: Frontiers in Nutrition
https://www.readbyqxmd.com/read/28759316/conservative-management-for-stable-high-ankle-injuries-in-professional-football-players
#5
Derrick M Knapik, Anthony Trem, Joseph Sheehan, Michael J Salata, James E Voos
CONTEXT: High ankle "syndesmosis" injuries are common in American football players relative to the general population. At the professional level, syndesmotic sprains represent a challenging and unique injury lacking a standardized rehabilitation protocol during conservative management. EVIDENCE ACQUISITION: PubMed, Biosis Preview, SPORTDiscus, PEDro, and EMBASE databases were searched using the terms syndesmotic injuries, American football, conservative management, and rehabilitation...
July 1, 2017: Sports Health
https://www.readbyqxmd.com/read/28754649/stretching-single-fibrin-fibers-hampers-their-lysis
#6
Wei Li, Tomas Lucioni, Rongzhong Li, Keith Bonin, Samuel S Cho, Martin Guthold
Blood clots, whose main structural component is a mesh of microscopic fibrin fibers, experience mechanical strain from blood flow, clot retraction and interactions with platelets and other cells. We developed a transparent, striated and highly stretchable substrate made from fugitive glue (a styrenic block copolymer) to investigate how mechanical strain affects lysis of single, suspended fibrin fibers. In this suspended fiber assay, lysis manifested itself by fiber elongation, thickening (disassembly), fraying and collapse...
July 25, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28750494/brain-pet-and-functional-mri-why-simultaneously-using-hybrid-pet-mr-systems
#7
Diego Cecchin, Alessandro Palombit, Marco Castellaro, Erica Silvestri, Franco Bui, Henryk Barthel, Osama Sabri, Maurizio Corbetta, Alessandra Bertoldo
INTRODUCTION: In the last 20 years growing attention has been devoted to multimodal imaging. The recent literature is rich of clinical and research studies that have been performed using different imaging modalities on both separate and integrated Positron Emission Tomography (PET) and Magnetic Resonance (MR) scanners. However, today, hybrid PET/MR systems measure signals related to brain structure, metabolism, neurochemistry, perfusion, and neuronal activity simultaneously, i.e. in the same physiological conditions...
July 27, 2017: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28750024/applying-time-frequency-analysis-to-assess-cerebral-autoregulation-during-hypercapnia
#8
Michał M Placek, Paweł Wachel, D Robert Iskander, Peter Smielewski, Agnieszka Uryga, Arkadiusz Mielczarek, Tomasz A Szczepański, Magdalena Kasprowicz
OBJECTIVE: Classic methods for assessing cerebral autoregulation involve a transfer function analysis performed using the Fourier transform to quantify relationship between fluctuations in arterial blood pressure (ABP) and cerebral blood flow velocity (CBFV). This approach usually assumes the signals and the system to be stationary. Such an presumption is restrictive and may lead to unreliable results. The aim of this study is to present an alternative method that accounts for intrinsic non-stationarity of cerebral autoregulation and the signals used for its assessment...
2017: PloS One
https://www.readbyqxmd.com/read/28744885/water-infused-surface-protection-as-an-active-mechanism-for-fibrin-sheath-prevention-in-central-venous-catheters
#9
David W Sutherland, Xin Zhang, Joseph L Charest
Protein adhesion in central venous catheters (CVCs) leads to fibrin sheath formation, the precursor to thrombotic and biofilm-related CVC failures. Advances in material properties and surface coatings do not completely prevent fibrin sheath formation and post-formation treatment options are limited and expensive. We propose water infused surface protection (WISP), an active method for prevention of fibrin sheath formation on CVCs, which creates a blood-free boundary layer on the inner surface of the CVC, limiting blood contact with the CVC lumen wall...
July 26, 2017: Artificial Organs
https://www.readbyqxmd.com/read/28737609/the-effects-of-supplementary-low-load-blood-flow-restriction-training-on-morphological-and-performance-based-adaptations-in-team-sport-athletes
#10
Brendan R Scott, Jeremiah J Peiffer, Paul S R Goods
Scott, BR, Peiffer, JJ, and Goods, PSR. The effects of supplementary low-load blood flow restriction training on morphological and performance-based adaptations in team sport athletes. J Strength Cond Res 31(8): 2147-2154, 2017-Low-load resistance training with blood flow restriction (BFR) may be a method to enhance muscular development even in trained athletes. This study aimed to assess whether supplemental low-load BFR training can improve muscle size, strength, and physical performance characteristics in team sport athletes...
August 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28735814/tyrosine-kinase-inhibitors-as-modulators-of-trastuzumab-mediated-antibody-dependent-cell-mediated-cytotoxicity-in-breast-cancer-cell-lines
#11
Denis M Collins, Kathy Gately, Clare Hughes, Connla Edwards, Anthony Davies, Stephen F Madden, Kenneth J O'Byrne, Norma O'Donovan, John Crown
BACKGROUND: Trastuzumab is an anti-HER2 monoclonal antibody (mAb) therapy capable of antibody-dependent cell-mediated cytotoxicity (ADCC) and used in the treatment of HER2+ breast cancer. Through interactions with FcƴR+ immune cell subsets, trastuzumab functions as a passive immunotherapy. The EGFR/HER2-targeting tyrosine kinase inhibitor (TKI) lapatinib and the next generation TKIs afatinib and neratinib, can alter HER2 levels, potentially modulating the ADCC response to trastuzumab...
July 15, 2017: Cellular Immunology
https://www.readbyqxmd.com/read/28726984/physiology-and-endocrinology-symposium-alterations-in-uteroplacental-hemodynamics-during-melatonin-supplementation-in-sheep-and-cattle
#12
C O Lemley, K A Vonnahme
Compromised placental function can result in fetal growth restriction which is associated with greater risk of neonatal morbidity and mortality. Large increases in transplacental nutrient and waste exchange, which support the exponential increase in fetal growth during the last half of gestation, are dependent primarily on the rapid growth and vascularization of the uteroplacenta. The amplitude of melatonin secretion has been associated with improved oxidative status and altered cardiovascular function in several mammalian species; however, melatonin mediated alterations of uteroplacental capacity in sheep and cattle are lacking...
May 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28725318/detection-of-apolipoprotein-e-gene-polymorphism-and-blood-lipid-level-in-hemodialysis-patients
#13
Yuxin Wang, Ning Wang, Yuanshan Lu, Qing Yu, Lina Zhou, Qinjun Xu
BACKGROUND: The aim was to investigate the clinical characteristics of lipid metabolism and the effect of apolipoprotein E (ApoE) gene polymorphism on lipid metabolism in hemodialysis patients. METHODS: The serum levels of total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDLC), low-density lipoprotein cholesterol (LDLC), ApoA1, ApoB, ApoE and lipoprotein Lp(a) were detected by polymerase chain reaction-restriction fragment length (PCR-RFLP)...
August 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28714969/endothelial-notch-signalling-limits-angiogenesis-via-control-of-artery-formation
#14
Sana S Hasan, Roman Tsaryk, Martin Lange, Laura Wisniewski, John C Moore, Nathan D Lawson, Karolina Wojciechowska, Hans Schnittler, Arndt F Siekmann
Angiogenic sprouting needs to be tightly controlled. It has been suggested that the Notch ligand dll4 expressed in leading tip cells restricts angiogenesis by activating Notch signalling in trailing stalk cells. Here, we show using live imaging in zebrafish that activation of Notch signalling is rather required in tip cells. Notch activation initially triggers expression of the chemokine receptor cxcr4a. This allows for proper tip cell migration and connection to the pre-existing arterial circulation, ultimately establishing functional arterial-venous blood flow patterns...
August 2017: Nature Cell Biology
https://www.readbyqxmd.com/read/28712063/resisting-sleep-pressure-impact-on-resting-state-functional-network-connectivity
#15
Laura Tüshaus, Joshua Henk Balsters, Anthony Schläpfer, Daniel Brandeis, Ruth O'Gorman Tuura, Peter Achermann
In today's 24/7 society, sleep restriction is a common phenomenon which leads to increased levels of sleep pressure in daily life. However, the magnitude and extent of impairment of brain functioning due to increased sleep pressure is still not completely understood. Resting state network (RSN) analyses have become increasingly popular because they allow us to investigate brain activity patterns in the absence of a specific task and to identify changes under different levels of vigilance (e.g. due to increased sleep pressure)...
July 15, 2017: Brain Topography
https://www.readbyqxmd.com/read/28710313/ex-vivo-pd-l1-pd-1-pathway-blockade-reverses-dysfunction-of-circulating-cea-specific-t-cells-in-pancreatic-cancer-patients
#16
Yuan Chen, Shao-An Xue, Shahriar Behboudi, Goran Hamid Mohammad, Stephen P Pereira, Emma Morris
Carcinoembryonic antigen (CEA) is a candidate target for cellular immunotherapy of pancreatic cancer (PC). In this study, we have characterised the antigen-specific function of autologous cytotoxic T lymphocytes (CTL) specific for the HLA-A2 restricted peptide, pCEA691-699, isolated from the peripheral T cell repertoire of PC patients and sought to determine if ex vivo PD-L1 & TIM3 blockade could enhance CTL function. CD8(+) T cell lines were generated from peripheral blood mononuclear cells (PBMCs) of 18 HLA-A2(+) patients with PC and from 15 healthy controls...
July 14, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28710023/transient-brain-hypothermia-reduces-the-reperfusion-injury-of-delayed-tissue-plasminogen-activator-and-extends-its-therapeutic-time-window-in-a-focal-embolic-stroke-model
#17
Mohammadreza Zarisfi, Fatemeh Allahtavakoli, Mahsa Hassanipour, Mohammad Khaksari, Hossain Rezazadeh, Mohammad Allahtavakoli, Mohammad Mohsen Taghavi
It has been reported that restriction of reperfusion after thrombolytic therapy in ischemic stroke may reduce tissue plasminogen activator (tPA) adverse effects and extend its time window. We examined whether shortIt has been reported that restriction of reperfusion after thrombolytic therapy in ischemic stroke may reduce tissue plasminogen activator (tPA) adverse effects and extend its time window. We examined whether short-term and mild local brain cooling can prevent hyperemia and/or adverse effects of delayed tPA in rat embolic stroke model...
July 11, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28708246/three-dimensional-power-doppler-evaluation-of-cerebral-vascular-blood-flow-a-novel-tool-in-the-assessment-of-fetal-growth-restriction
#18
Katherine R Goetzinger, Alison G Cahill, Linda Odibo, George A Macones, Anthony O Odibo
OBJECTIVES: To determine whether fetuses with fetal growth restriction (FGR) are more likely to have abnormal cerebral vascular flow patterns compared to fetuses who are appropriate for gestational age (AGA) when quantified by using 3-dimensional (3D) power Doppler ultrasound. METHODS: We conducted a prospective cohort study of singleton gestations presenting for growth ultrasound examination between 24 and 36 weeks' gestation. Patients with FGR (estimated fetal weight < 10th percentile) were enrolled and matched 1:1 for gestational age (±7 days) with AGA fetuses...
July 14, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28706859/role-of-metabolic-stress-for-enhancing-muscle-adaptations-practical-applications
#19
REVIEW
Marcelo Conrado de Freitas, Jose Gerosa-Neto, Nelo Eidy Zanchi, Fabio Santos Lira, Fabrício Eduardo Rossi
Metabolic stress is a physiological process that occurs during exercise in response to low energy that leads to metabolite accumulation [lactate, phosphate inorganic (Pi) and ions of hydrogen (H(+))] in muscle cells. Traditional exercise protocol (i.e., Resistance training) has an important impact on the increase of metabolite accumulation, which influences hormonal release, hypoxia, reactive oxygen species (ROS) production and cell swelling. Changes in acute exercise routines, such as intensity, volume and rest between sets, are determinants for the magnitude of metabolic stress, furthermore, different types of training, such as low-intensity resistance training plus blood flow restriction and high intensity interval training, could be used to maximize metabolic stress during exercise...
June 26, 2017: World Journal of Methodology
https://www.readbyqxmd.com/read/28704612/blood-flow-in-humans-following-low-load-exercise-with-and-without-blood-flow-restriction
#20
J Grant Mouser, Gilberto C Laurentino, Scott J Dankel, Samuel L Buckner, Matthew B Jessee, Brittany R Counts, Kevin T Mattocks, Jeremy P Loenneke
Blood flow restriction (BFR) in combination with exercise has been used to increase muscle size and strength using relatively low loads (20%-30% 1RM). In research, the range of applied pressures based on a percentage of arterial occlusion pressure (AOP), is wide. PURPOSE: To measure the blood flow response before, following each set of exercise, and post exercise to low-load elbow flexion combined with no restriction (NOBFR), 40% of AOP (40BFR), and 80% of AOP (80BFR). METHODS: 152 participants volunteered; 140 completed the protocol (women=75, men=65)...
July 13, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
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