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Blood flow restriction

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https://www.readbyqxmd.com/read/28538566/predicting-thrombosis-formation-in-1-mm-diameter-arterial-anastomoses-with-transit-time-ultrasound-technology
#1
Gabrielle Shaughness, Collin Blackburn, Alberto Ballestín, Yelena Akelina, Jeffrey A Ascherman
BACKGROUND: Thrombosis is a common source of failure in anastomoses, flaps, and vascular grafts. Ensuring vessel patency is critical to the success of microvascular procedures. Any tool that can accurately predict the patency of an anastomosis intraoperatively would enable the surgeon to detect and correct flow restrictions while the patient is still in the operating room. METHODS: The authors used transit-time ultrasound technology in this pilot study to investigate whether a minimal cutoff value for quantitative postoperative blood flow (in milliliters per minute) could be established that would reliably predict sustained vessel patency at 24 hours postoperatively...
June 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28534661/characterization-of-human-fetal-brain-endothelial-cells-reveals-barrier-properties-suitable-for-in%C3%A2-vitro-modeling-of-the-bbb-with-syngenic-co-cultures
#2
Allison M Andrews, Evan M Lutton, Lee A Cannella, Nancy Reichenbach, Roshanak Razmpour, Matthew J Seasock, Steven J Kaspin, Steven F Merkel, Dianne Langford, Yuri Persidsky, Servio H Ramirez
Endothelial cells (ECs) form the basis of the blood-brain barrier (BBB), a physical barrier that selectively restricts transport into the brain. In vitro models can provide significant insight into BBB physiology, mechanisms of human disease pathology, toxicology, and drug delivery. Given the limited availability of primary human adult brain microvascular ECs ( aBMVECs), human fetal tissue offers a plausible alternative source for multiple donors and the opportunity to build syngenic tri-cultures from the same host...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28532814/control-aspects-of-the-human-cardiovascular-respiratory-system-under-a-nonconstant-workload
#3
Pio Gabrielle B Calderon, Mustafa Habib, Franz Kappel, Aurelio A de Los Reyes V
The human cardiovascular system (CVS) and respiratory system (RS) work together in order to supply oxygen (O2) and other substrates needed for metabolism and to remove carbon dioxide (CO2). Global and local control mechanisms act on the CVS in order to adjust blood flow to the different parts of the body. This, in turn, affects the RS since the amount of O2 and CO2 transported, respectively to and away from the tissues depends on the cardiac output and blood flow in both the systemic and pulmonary circuits of the CVS...
May 19, 2017: Mathematical Biosciences
https://www.readbyqxmd.com/read/28528294/isoliquiritigenin-reduces-oxidative-damage-and-alleviates-mitochondrial-impairment-by-sirt1-activation-in-experimental-diabetic-neuropathy
#4
Veera Ganesh Yerra, Anil Kumar Kalvala, Ashutosh Kumar
Sirtuin (SIRT1) inactivation underlies the pathogenesis of insulin resistance and hyperglycaemia-associated vascular complications, but its role in diabetic neuropathy (DN) has not been yet explored. We have evaluated hyperglycaemia-induced alteration of SIRT1 signalling and the effect of isoliquiritigenin (ILQ) on SIRT1-directed AMP kinase (AMPK) and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) signalling in peripheral nerves of streptozotocin (STZ) (55 mg/kg, ip)-induced diabetic rats and in high glucose (30 mM)-exposed neuro2a (N2A) cells...
May 11, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28526302/an-important-role-of-vegf-c-in-promoting-lymphedema-development
#5
Epameinondas Gousopoulos, Steven T Proulx, Samia B Bachmann, Lothar C Dieterich, Jeannette Scholl, Sinem Karaman, Roberta Bianchi, Michael Detmar
Secondary lymphedema is a common post-cancer treatment complication but the pathomechanisms underlying the disease remain unclear. Using a mouse-tail lymphedema model, we found an increase in local and systemic levels of the lymphangiogenic factor VEGF-C, and identified CD68+ macrophages as a cellular source. Surprisingly, overexpression of VEGF-C in a transgenic mouse model led to aggravation of lymphedema with increased immune cell infiltration and vascular leakage in comparison to wild-type littermates. Conversely, blockage of VEGF-C by overexpression of soluble VEGFR3 reduced edema development, diminishing inflammation and blood vascular leakage...
May 16, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28513326/the-effects-of-blood-flow-restricted-electrostimulation-on-strength-hypertrophy
#6
Joshua Slysz, Jamie F Burr
CONTEXT: The combined effect of neuromuscular electrical muscle stimulation (NMES) and blood flow restriction (BFR) on muscle mass and strength has not been thoroughly investigated. OBJECTIVE: To examine the effects of combined and independent BFR and a low-intensity NMES on skeletal muscle adaptation. DESIGN: Exploratory Study. SETTING: Laboratory. PARTICIPANTS: Twenty recreationally active subjects...
May 17, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/28505959/the-application-of-a-pre-positioned-upper-cervical-traction-mobilization-to-patients-with-painful-active-cervical-rotation-impairment-a-case-series
#7
Douglas S Creighton, Doug Marsh, Mark Gruca, Melissa Walter
BACKGROUND: Cervical mobilization and manipulation have been shown to improve cervical range of motion and pain. Cervical rotatory thrust manipulation has been associated with adverse patient reaction and damage to the V3 segment of the vertebral artery (VA). OBJECTIVE: To document and describe the effects of an upper cervical (UC) traction based mobilization on participants with restricted and painful cervical rotation and to document if the mobilization changed blood flow velocity through the vertebral artery...
May 5, 2017: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/28502262/effects-of-combined-iugr-and-prenatal-stress-on-the-development-of-the-hippocampus-in-a-fetal-guinea-pig-model
#8
A L Cumberland, H K Palliser, P Rani, D W Walker, J J Hirst
Intrauterine growth restriction (IUGR) and maternal stress during pregnancy are two compromises that negatively impact neurodevelopment and increase the risk of developing later life neuropsychiatric disorders such as schizophrenia, depression and behavioural disorders. Neurosteroids, particularly allopregnanolone, are important in protecting the developing brain and promoting many essential neurodevelopmental processes. Individually, IUGR and prenatal stress (PS) reduce myelination and neurogenesis within affected fetal brains, however less information is available on the combined effects of these two disorders on the term fetal brain...
May 15, 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/28501908/a-tale-of-three-cuffs-the-hemodynamics-of-blood-flow-restriction
#9
J Grant Mouser, Scott J Dankel, Matthew B Jessee, Kevin T Mattocks, Samuel L Buckner, Brittany R Counts, Jeremy P Loenneke
INTRODUCTION: The blood flow response to relative levels of blood flow restriction (BFR) across varying cuff widths is not well documented. With the variety of cuff widths and pressures reported in the literature, the effects of different cuffs and pressures on blood flow require investigation. PURPOSE: To measure blood pressure using three commonly used BFR cuffs, examine possible venous/arterial restriction pressures, and measure hemodynamic responses to relative levels of BFR using these same cuffs...
May 13, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28500081/quadriceps-strengthening-with-and-without-blood-flow-restriction-in-the-treatment-of-patellofemoral-pain-a-double-blind-randomised-trial
#10
Lachlan Giles, Kate E Webster, Jodie McClelland, Jill L Cook
BACKGROUND: Quadriceps strengthening exercises are part of the treatment of patellofemoral pain (PFP), but the heavy resistance exercises may aggravate knee pain. Blood flow restriction (BFR) training may provide a low-load quadriceps strengthening method to treat PFP. METHODS: Seventy-nine participants were randomly allocated to a standardised quadriceps strengthening (standard) or low-load BFR. Both groups performed 8 weeks of leg press and leg extension, the standard group at 70% of 1 repetition maximum (1RM) and the BFR group at 30% of 1RM...
May 12, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28493330/improved-panels-for-clinical-immune-phenotyping-utilization-of-the-violet-laser
#11
Mark Ryherd, Matthew Plassmeyer, Connor Alexander, Ines Eugenio, Yuliya Kleschenko, Ariel Badger, Raavi Gupta, Oral Alpan, Søren Ulrik Sønder
BACKGROUND: Clinical diagnostic laboratories are subject to numerous regulations imposed by government agencies. Laboratory developed tests for flow cytometry panels are essentially restricted to the use of analyte-specific reagents (ASR) antibodies. With the advances in clinical flow cytometry systems, there is a trend toward the utilization of blue/red/violet laser flow systems and 8 to 10-color panels. Currently, the selection of commercially available ASR antibodies for the violet laser is very limited...
May 10, 2017: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/28488836/effects-of-low-load-resistance-exercise-with-blood-flow-restriction-on-intramuscular-hemodynamics-oxygenation-level-and-water-content
#12
Osamu Yanagisawa, Atsuki Fukutani
BACKGROUND: Muscle metabolism during and after low-load blood flow restriction (BFR) exercise should be further investigated to clarify the mechanism by which the exercise leads to muscle hypertrophy, and increases strength and endurance. We aimed to investigate the effects of low-load resistance exercise with BFR on intramuscular hemodynamics, oxygenation level, and water content. METHODS: Seven men performed ankle plantar flexion exercise (120 repetitions, 30% one repetition maximum) using a custom-made device with and without BFR inside a magnetic resonance scanner...
May 9, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28483805/treating-the-dysfunctional-placenta
#13
Colin Peter Sibley
Placental dysfunction underlies major obstetric diseases such as pre-eclampsia and fetal growth restriction (FGR). Whilst there has been a little progress in prophylaxis there are still no treatments for placental dysfunction in normal obstetric practice. However, a combination of increasingly well described in vitro systems for studying the human placenta, together with the availability of more appropriate animal models of pre-eclampsia and FGR, has facilitated a recent surge in work aimed at repurposing drugs and therapies, developed for other conditions, as treatments for placental dysfunction...
May 8, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28483555/blood-flow-restriction-walking-and-physical-function-in-older-adults-a-randomized-control-trial
#14
Matthew John Clarkson, Louise Conway, Stuart Anthony Warmington
OBJECTIVES: The progressive age-related declines in muscle health and physical function in older adults are related to muscle size and strength. Walking with an applied blood flow restriction is an alternative to maintain muscle volume in older adults to increase the value for time spent walking. Therefore, the aim of this study was to examine the effect of adding blood flow restriction to low-intensity walking on clinical measures of physical function. DESIGN/METHODS: Sedentary older men and women were randomised to either a low-intensity blood flow restriction walking group (BFRW; n=10), or a non-blood flow restriction walking control group (CON; n=9)...
April 21, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28481416/blood-flow-restricted-training-leads-to-myocelullar-macrophage-infiltration-and-upregulation-of-heat-shock-proteins-but-no-apparent-muscle-damage
#15
Jakob L Nielsen, Per Aagaard, Tatyana A Prokhorova, Tobias Nygaard, Rune Dueholm Bech, Charlotte Suetta, Ulrik Frandsen
Previous studies indicate that low-load muscle contractions performed under local blood-flow restriction (BFR) may initially induce muscle damage and stress. However, whether these factors are evoked with longitudinal BFR training remains unexplored at the myocellular level. Two distinct study protocols were conducted (3 wk/1 wk). Subjects performed BFR exercise (100 mmHg, 20%-1RM) to concentric failure (BFRE) (3 wk/1 wk), while controls performed work-matched (LLE)(3 wk) or high-load (HLE; 70%-1RM)(1 wk), free-flow exercise...
May 8, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28465588/improved-analytical-sensitivity-of-lateral-flow-assay-using-sponge-for-hbv-nucleic-acid-detection
#16
Ruihua Tang, Hui Yang, Yan Gong, Zhi Liu, XiuJun Li, Ting Wen, ZhiGuo Qu, Sufeng Zhang, Qibing Mei, Feng Xu
Hepatitis B virus (HBV) infection is a serious public health problem, which can be transmitted through various routes (e.g., blood donation) and cause hepatitis, liver cirrhosis and liver cancer. Hence, it is necessary to do diagnostic screening for high-risk HBV patients in these transmission routes. Nowadays, protein-based technologies have been used for HBV testing, which however involve the issues of large sample volume, antibody instability and poor specificity. Nucleic acid hybridization-based lateral flow assay (LFA) holds great potential to address these limitations due to its low-cost, rapid, and simple features, but the poor analytical sensitivity of LFA restricts its application...
May 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28465086/dual-7-ethyl-10-hydroxycamptothecin-conjugated-phospholipid-prodrug-assembled-liposomes-with-in-vitro-anticancer-effects
#17
Yawei Du, Wei Zhang, Ruiyu He, Muhammad Ismail, Longbing Ling, Chen Yao, Zhenglin Fu, Xinsong Li
7-Ethyl-10-hydroxycamptothecin (SN38), as a highly active topoisomerase I inhibitor, is 200-2000-fold more cytotoxic than irinotecan (CPT-11) commercially available as Camptosar®. However, poor solubility and low stability extensively restricted its clinical utility. In this report, dual SN38 phospholipid conjugate (Di-SN38-PC) prodrug based liposomes were developed in order to compact these drawbacks. Di-SN38-PC prodrug was first synthesized by inhomogeneous conjugation of two SN38-20-O-succinic acid molecules with L-α-glycerophosphorylcholine (GPC)...
April 22, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28451748/effects-of-4%C3%A2-weeks-of-low-load-unilateral-resistance-training-with-and-without-blood-flow-restriction-on-strength-thickness-v-wave-and-h-reflex-of-the-soleus-muscle-in-men
#18
David Colomer-Poveda, Salvador Romero-Arenas, Antonio Vera-Ibáñez, Manuel Viñuela-García, Gonzalo Márquez
PURPOSE: To test the effects of 4 weeks of unilateral low-load resistance training (LLRT), with and without blood flow restriction (BFR), on maximal voluntary contraction (MVC), muscle thickness, volitional wave (V wave), and Hoffmann reflex (H reflex) of the soleus muscle. METHODS: Twenty-two males were randomly distributed into three groups: a control group (CTR; n = 8); a low-load blood flow restriction resistance training group (BFR-LLRT; n = 7), who were an inflatable cuff to occlude blood flow; and a low-load resistance training group without blood flow restriction (LLRT; n = 7)...
April 27, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28448983/intrauterine-growth-restriction-alters-the-postnatal-development-of-the-rat-cerebellum
#19
Annie R A McDougall, Vanny Wiradjaja, Aminath Azhan, Anqi Li, Nadia Hale, Mary E Wlodek, Stuart B Hooper, Megan J Wallace, Mary Tolcos
Intrauterine growth restriction (IUGR) is a major cause of antenatal brain injury. We aimed to characterize cerebellar deficits following IUGR and to investigate the potential underlying cellular and molecular mechanisms. At embryonic day 18, pregnant rats underwent either sham surgery (controls; n = 23) or bilateral uterine vessel ligation to restrict blood flow to fetuses (IUGR; n = 20). Offspring were collected at postnatal day 2 (P2), P7, and P35. Body weights were reduced at P2, P7, and P35 in IUGR offspring (p < 0...
April 28, 2017: Developmental Neuroscience
https://www.readbyqxmd.com/read/28448687/postexercise-blood-flow-restriction-does-not-enhance-muscle-hypertrophy-induced-by-multiple-set-high-load-resistance-exercise
#20
Haruhiko Madarame, Satoshi Nakada, Takahisa Ohta, Naokata Ishii
To test the applicability of postexercise blood flow restriction (PEBFR) in practical training programmes, we investigated whether PEBFR enhances muscle hypertrophy induced by multiple-set high-load resistance exercise (RE). Seven men completed an eight-week RE programme for knee extensor muscles. Employing a within-subject design, one leg was subjected to RE + PEBFR, whereas contralateral leg to RE only. On each exercise session, participants performed three sets of unilateral knee extension exercise at approximately 70% of their one-repetition maximum for RE leg first, and then performed three sets for RE + PEBFR leg...
April 27, 2017: Clinical Physiology and Functional Imaging
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