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https://www.readbyqxmd.com/read/28893206/efficacy-of-blood-flow-restriction-exercise-during-dialysis-for-end-stage-kidney-disease-patients-protocol-of-a-randomised-controlled-trial
#1
Matthew J Clarkson, Steve F Fraser, Paul N Bennett, Lawrence P McMahon, Catherine Brumby, Stuart A Warmington
BACKGROUND: Exercise during haemodialysis improves strength and physical function. However, both patients and clinicians are time poor, and current exercise recommendations add an excessive time burden making exercise a rare addition to standard care. Hypothetically, blood flow restriction exercise performed during haemodialysis can provide greater value for time spent exercising, reducing this time burden while producing similar or greater outcomes. This study will explore the efficacy of blood flow restriction exercise for enhancing strength and physical function among haemodialysis patients...
September 11, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28892981/effect-of-transdermal-nitroglycerine-on-doppler-velocity-waveforms-of-the-uterine-umbilical-and-fetal-middle-cerebral-arteries-in-patients-with-chronic-placental-insufficiency-a-prospective-rct
#2
Suruchi Gupta, Meenakshi Chauhan, Jyotsna Sen, Smiti Nanda
INTRODUCTION: Increase in Nitric Oxide (NO) may be important in vascular adaptation needed to accommodate increased uteroplacental blood flow as pregnancy advances. Hence, in certain conditions like Pregnancy Induced Hypertension (PIH) and Fetal Growth Restriction (FGR), NO donors may play an effective role in increasing uteroplacental perfusion. Transdermal route appears to be a safe and effective route. AIM: To evaluate the effect of nitroglycerine patch on Doppler velocity waveforms of the uterine, umbilical and fetal middle cerebral arteries in patients with chronic placental insufficiency...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28890678/pregnancy-following-laparoscopic-hysteropexy-a-case-series
#3
Helen Jefferis, Natalia Price, Simon Jackson
BACKGROUND: Uterine-preserving prolapse surgery offers the chance to retain fertility; however, limited data is available for the safety of pregnancy following surgery and the effect of pregnancy on surgical outcome. Our operative technique involves mesh encircling the cervix and uterine arteries, which raises concerns that compromise of uterine blood flow during pregnancy may lead to foetal growth restriction. We also think this necessitates delivery by caesarean section. We report on six pregnancy outcomes following laparoscopic hysteropexy...
2017: Gynecological Surgery
https://www.readbyqxmd.com/read/28889225/effects-of-blood-flow-restriction-during-moderate-intensity-eccentric-knee-extensions
#4
Michael Behringer, Lars Heinke, Jannik Leyendecker, Joachim Mester
We investigated if blood flow restriction (BFR, cuff pressure 20 mmHG below individual occlusion pressure) increases metabolic stress, hormonal response, release of muscle damage markers, and muscle swelling induced by moderate-intensity eccentric contractions. In a randomized, matched-pair design, 20 male subjects (25.3 ± 3.3 years) performed four sets of unilateral eccentric knee extensions (75% 1RM) to volitional failure with (IG) or without (CG) femoral BFR. Despite significant differences of performed repetitions between IG (85...
September 9, 2017: Journal of Physiological Sciences: JPS
https://www.readbyqxmd.com/read/28887730/an-exploration-of-the-reflow-technique-for-the-fabrication-of-an-in-vitro-microvascular-system-to-study-occlusive-clots
#5
Yang Li, Chuer Pan, Yunfeng Li, Eugenia Kumacheva, Arun Ramachandran
Embolic ischemia and pulmonary embolism are health emergencies that arise when a particle such as a blood clot occludes a smaller blood vessel in the brain or the lungs, and restricts flow of blood downstream of the vessel. In this work, the reflow technique (Wang et al. Biomed. Microdevices 2007, 9, 657) was adapted to produce a microchannel network that mimics the occlusion process. The technique was first revisited and a simple geometrical model was developed to quantitatively explain the shapes of the resulting microchannels for different reflow parameters...
September 8, 2017: Biomedical Microdevices
https://www.readbyqxmd.com/read/28883228/paget-schroetter-syndrome-resulting-from-thoracic-outlet-syndrome-and-kaatsu-training
#6
Tatsunori Noto, Go Hashimoto, Takahito Takagi, Toru Awaya, Tadashi Araki, Masanori Shiba, Raisuke Iijima, Hidehiko Hara, Masao Moroi, Masato Nakamura, Kaoru Sugi
A 29-year-old woman who worked as a KAATSU (a type of body exercise that involves blood flow restriction) instructor visited our emergency room with a chief complaint of swelling and left upper limb pain. Chest computed tomography (CT) showed non-uniform contrast images corresponding to the site from the left axillary vein to the left subclavian vein; vascular ultrasonography of the upper limb revealed a thrombotic obstruction at the same site, leading to a diagnosis of Paget-Schroetter syndrome (PSS). We herein report our experience with a case of PSS derived from thoracic outlet syndrome (TOS), in a patient who was a KAATSU instructor...
September 6, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28854716/livebirth-and-utero-placental-insufficiency-in-papio-hamadryas-baboons-with-uterus-angiosome-perfused-by-bilateral-utero-ovarian-microsurgical-anastomoses-alone
#7
B Beran, K Arnolds, M Shockley, K Rivas, M Medina, P F Escobar, A Tzakis, T Falcone, M L Sprague, S Zimberg
STUDY QUESTION: Can the baboon uterus support a gestation to livebirth with an angiosome using microsurgically anastomosed utero-ovarian vessels and lacking uterine arteries and veins? SUMMARY ANSWER: Our angiosome model allows healthy livebirth albeit with risk of fetal growth restriction and stillbirth. WHAT IS KNOWN ALREADY: Uterine transplant can provide livebirth in humans, but requires a living donor to undergo a prolonged laparotomy for hysterectomy...
September 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28853118/occlusion-training-pilot-study-for-postoperative-lower-extremity-rehabilitation-following-primary-total-knee-arthroplasty
#8
Christopher L Gaunder, Michael P Hawkinson, David J Tennent, Creighton C Tubb
With continued emphasis on the value of healthcare, factors such as quality of life and patient reported outcomes are critical in evaluating high-demand procedures such as knee replacement surgery. Equally important to the surgery itself is maximizing the effectiveness and efficiency of the treatment, both preoperatively and postoperatively, which can have a significant effect the final outcome. Technical outcomes of total knee replacement are generally considered excellent; however, many patients continue to have postoperative pain, functional limitations, and low treatment satisfaction...
July 2017: U.S. Army Medical Department Journal
https://www.readbyqxmd.com/read/28846579/comparison-of-direct-site-endovascular-repair-utilizing-expandable-polytetrafluoroethylene-stent-grafts-versus-standard-vascular-shunts-in-a-porcine-sus-scrofa-model
#9
COMPARATIVE STUDY
Anders J Davidson, Lucas P Neff, J Kevin Grayson, Nathan F Clement, Erik S DeSoucy, Meryl A Simon Logan, Christopher M Abbot, James B Sampson, Timothy K Williams
INTRODUCTION: The small diameter of temporary vascular shunts for vascular trauma management may restrict flow and result in ischemia or early thrombosis. We have previously reported a clinical experience with direct, open surgical reconstruction using expandable polytetrafluoroethylene stent grafts to create a "sutureless" anastomosis as an alternative to standard temporary vascular shunts. We sought to characterize patency and flow characteristics of these grafts compared with standard shunts in a survival model of porcine vascular injury...
September 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28835448/cyclical-blood-flow-restriction-resistance-exercise-a-potential-parallel-to-remote-ischemic-preconditioning
#10
Justin Daniel Sprick, Caroline A Rickards
Remote ischemic preconditioning (RIPC) is characterized by the cyclical application of limb blood flow restriction and reperfusion, and has been shown to protect vital organs during a subsequent ischemic insult. Blood flow restriction exercise (BFRE) similarly combines bouts of blood flow restriction with low-intensity exercise and thus could potentially emulate the protection demonstrated by RIPC. One concern with BFRE, however, is the potential for an augmented rise in sympathetic outflow, due to greater activation of the exercise pressor reflex...
August 23, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28835447/combining-remote-ischemic-preconditioning-and-aerobic-exercise-a-novel-adaptation-of-blood-flow-restriction-exercise
#11
Justin Daniel Sprick, Caroline A Rickards
Remote ischemic preconditioning (RIPC) can attenuate tissue damage sustained by ischemia-reperfusion injury. Blood flow restriction exercise (BFRE) restricts blood flow to exercising muscles. We implemented a novel approach to BFRE with cyclical bouts of blood flow restriction-reperfusion, reflecting the RIPC model. A concern about BFRE, however, is potential amplification of the exercise pressor reflex, which could be unsafe in at-risk populations. We hypothesized that cyclical BFRE would elicit greater increases in sympathetic outflow and arterial pressure than conventional exercise (CE), performed at the same relative intensity...
August 23, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28828264/exercise-training-with-dietary-restriction-enhances-circulating-irisin-level-associated-with-increasing-endothelial-progenitor-cell-number-in-obese-adults-an-intervention-study
#12
Junhao Huang, Shen Wang, Fengpeng Xu, Dan Wang, Honggang Yin, Qinhao Lai, Jingwen Liao, Xiaohui Hou, Min Hu
OBJECTIVE: Circulating endothelial progenitor cells (EPCs) correlate negatively with obesity. Previous studies have shown that exercise significantly restores circulating EPC levels in obese people; however, the underlying mechanisms have not been elucidated. Recently, irisin has been reported to have a critical role in the regulation of EPCs. This exercise-induced myokine has been demonstrated to play a therapeutic role in obesity. In this study, we hypothesized that the increase in circulating irisin may form a link with increasing EPC levels in obese people after exercise...
2017: PeerJ
https://www.readbyqxmd.com/read/28820467/aquaporin-4-functionality-and-virchow-robin-space-water-dynamics-physiological-model-for-neurovascular-coupling-and-glymphatic-flow
#13
REVIEW
Tsutomu Nakada, Ingrid L Kwee, Hironaka Igarashi, Yuji Suzuki
The unique properties of brain capillary endothelium, critical in maintaining the blood-brain barrier (BBB) and restricting water permeability across the BBB, have important consequences on fluid hydrodynamics inside the BBB hereto inadequately recognized. Recent studies indicate that the mechanisms underlying brain water dynamics are distinct from systemic tissue water dynamics. Hydrostatic pressure created by the systolic force of the heart, essential for interstitial circulation and lymphatic flow in systemic circulation, is effectively impeded from propagating into the interstitial fluid inside the BBB by the tightly sealed endothelium of brain capillaries...
August 18, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28806784/structural-analysis-of-p-falciparum-kahrp-and-pfemp1-complexes-with-host-erythrocyte-spectrin-suggests-a-model-for-cytoadherent-knob-protrusions
#14
Erin E Cutts, Niklas Laasch, Dirk M Reiter, Raphael Trenker, Leanne M Slater, Phillip J Stansfeld, Ioannis Vakonakis
Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) and Knob-associated Histidine-rich Protein (KAHRP) are directly linked to malaria pathology. PfEMP1 and KAHRP cluster on protrusions (knobs) on the P. falciparum-infected erythrocyte surface and enable pathogenic cytoadherence of infected erythrocytes to the host microvasculature, leading to restricted blood flow, oxygen deprivation and damage of tissues. Here we characterize the interactions of PfEMP1 and KAHRP with host erythrocyte spectrin using biophysical, structural and computational approaches...
August 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28802108/do-environmental-factors-affect-male-fathead-minnow-pimephales-promelas-response-to-estrone-part-2-temperature-and-food-availability
#15
N W Shappell, D J Feifarek, D C Rearick, S E Bartell, H L Schoenfuss
Fish are subject to constantly changing environmental conditions and food availability, factors that may impact their response to endocrine disruptors (EDs). This may, in part, explain outcome discrepancies between field studies and laboratory exposures to EDs. This study assessed whether standard laboratory conditions for fish exposures adequately represent effects of ED exposure at two environmentally realistic temperatures. The impact of temperature and food availability on male fathead minnow response to estrone (E1) exposure was studied in two experiments (3×2×2 factorial design) with three E1 concentrations (range 0-135ng/L); two temperatures (18°C and 26°C, the latter the prescribed laboratory temperature), and two feeding treatments (full fed vs...
August 9, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28772037/cardiac-and-peripheral-autonomic-control-in-restrictive-cardiomyopathy
#16
Ana Luiza C Sayegh, Marcelo R Dos Santos, Adriana O Sarmento, Francis R de Souza, Vera M C Salemi, Viviane T Hotta, Akothirene Cristhina D B Marques, Heidrum H Krämer, Ivani C Trombetta, Charles Mady, Maria Janieire de Nazaré Nunes Alves
AIMS: Autonomic dysfunction determines the advance of dilated cardiomyopathy (DCM) and is related to poor outcomes. However, this autonomic imbalance is unknown in patients with restrictive cardiomyopathy (RCM) even though they have similar symptoms and poor quality of life as DCM patients have. The aim of this study was to evaluate if autonomic and neurovascular controls were altered in RCM patients. METHODS AND RESULTS: Fifteen RCM patients, 10 DCM patients, and 10 healthy subjects were evaluated...
August 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/28770207/aberrant-cerebral-blood-flow-in-response-to-hunger-and-satiety-in-women-remitted-from-anorexia-nervosa
#17
Christina E Wierenga, Amanda Bischoff-Grethe, Grace Rasmusson, Ursula F Bailer, Laura A Berner, Thomas T Liu, Walter H Kaye
The etiology of pathological eating in anorexia nervosa (AN) remains poorly understood. Cerebral blood flow (CBF) is an indirect marker of neuronal function. In healthy adults, fasting increases CBF, reflecting increased delivery of oxygen and glucose to support brain metabolism. This study investigated whether women remitted from restricting-type AN (RAN) have altered CBF in response to hunger that may indicate homeostatic dysregulation contributing to their ability to restrict food. We compared resting CBF measured with pulsed arterial spin labeling in 21 RAN and 16 healthy comparison women (CW) when hungry (after a 16-h fast) and after a meal...
2017: Frontiers in Nutrition
https://www.readbyqxmd.com/read/28759316/conservative-management-for-stable-high-ankle-injuries-in-professional-football-players
#18
Derrick M Knapik, Anthony Trem, Joseph Sheehan, Michael J Salata, James E Voos
CONTEXT: High ankle "syndesmosis" injuries are common in American football players relative to the general population. At the professional level, syndesmotic sprains represent a challenging and unique injury lacking a standardized rehabilitation protocol during conservative management. EVIDENCE ACQUISITION: PubMed, Biosis Preview, SPORTDiscus, PEDro, and EMBASE databases were searched using the terms syndesmotic injuries, American football, conservative management, and rehabilitation...
July 1, 2017: Sports Health
https://www.readbyqxmd.com/read/28754649/stretching-single-fibrin-fibers-hampers-their-lysis
#19
Wei Li, Tomas Lucioni, Rongzhong Li, Keith Bonin, Samuel S Cho, Martin Guthold
Blood clots, whose main structural component is a mesh of microscopic fibrin fibers, experience mechanical strain from blood flow, clot retraction and interactions with platelets and other cells. We developed a transparent, striated and highly stretchable substrate made from fugitive glue (a styrenic block copolymer) to investigate how mechanical strain affects lysis of single, suspended fibrin fibers. In this suspended fiber assay, lysis manifested itself by fiber elongation, thickening (disassembly), fraying and collapse...
July 25, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28750494/brain-pet-and-functional-mri-why-simultaneously-using-hybrid-pet-mr-systems
#20
Diego Cecchin, Alessandro Palombit, Marco Castellaro, Erica Silvestri, Franco Bui, Henryk Barthel, Osama Sabri, Maurizio Corbetta, Alessandra Bertoldo
INTRODUCTION: In the last 20 years growing attention has been devoted to multimodal imaging. The recent literature is rich of clinical and research studies that have been performed using different imaging modalities on both separate and integrated Positron Emission Tomography (PET) and Magnetic Resonance (MR) scanners. However, today, hybrid PET/MR systems measure signals related to brain structure, metabolism, neurochemistry, perfusion, and neuronal activity simultaneously, i.e. in the same physiological conditions...
July 27, 2017: Quarterly Journal of Nuclear Medicine and Molecular Imaging
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