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https://www.readbyqxmd.com/read/29683314/enantioselective-effects-of-metalaxyl-enantiomers-in-adolescent-rat-metabolic-profiles-using-nmr-based-metabolomics
#1
Jinping Gu, Chenyang Ji, Siqing Yue, Dan Shu, Feng Su, Yinjun Zhang, Yuanyuan Xie, Yi Zhang, Weiping Liu, Meirong Zhao
More than 30% of the registered pesticides are chiral with one or more chiral centers and exist as two or more enantiomers. The frequency of chiral chemicals and their environmental safety has been considered in their risk assessment in recent decades. Despite the fact that metabolic disturbance is an important sensitive molecular initiating event of toxicology effects, the potential mechanisms of how chiral compounds affect metabolism phenotypes in organisms remain unclear. As a typical chiral pesticide, metalaxyl is an acylalanine fungicide with systemic function...
April 23, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29682004/investigating-plasma-amino-acids-for-differentiating-individuals-with-autism-spectrum-disorder-and-typically-developing-peers
#2
Troy Vargason, Uwe Kruger, Deborah L McGuinness, James B Adams, Elizabeth Geis, Eva Gehn, Devon Coleman, Juergen Hahn
Background: Plasma amino acid measurements have been extensively investigated in individuals with autism spectrum disorder (ASD). Results thus far have been inconclusive as studies generally disagree on which amino acids are different in individuals with ASD versus their typically developing (TD) peers, due in part to methodological limitations of several studies. Method: This paper investigates plasma amino acids in children and adults with ASD using data from Arizona State University's Comprehensive Nutritional and Dietary Intervention Study...
June 2018: Research in Autism Spectrum Disorders
https://www.readbyqxmd.com/read/29681857/a-synthesized-glucocorticoid-induced-leucine-zipper-peptide-inhibits-retinal-m%C3%A3-ller-cell-gliosis
#3
Ruiping Gu, Xinyi Ding, Wenyi Tang, Boya Lei, Chen Jiang, Gezhi Xu
Purpose: The anti-inflammatory activities of protein glucocorticoid-induced leucine zipper (GILZ) have been demonstrated in vivo and in vitro . Here, we examined the potential effect of a synthetic peptide derived from the leucine zipper motif and proline-rich region of GILZ on suppressing inflammatory responses in primary cultured rat Müller cells. Methods: Peptides were selected from amino acids 98-134 of the GILZ protein (GILZ-p). Solid-phase peptide synthesis was used to generate the cell-penetrating peptide TAT, which was bound to the amino terminus of GILZ-p...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29681752/molecular-aspects-of-flower-senescence-and-strategies-to-improve-flower-longevity
#4
REVIEW
Kenichi Shibuya
Flower longevity is one of the most important traits for ornamental plants. Ethylene plays a crucial role in flower senescence in some plant species. In several species that show ethylene-dependent flower senescence, genetic modification targeting genes for ethylene biosynthesis or signaling has improved flower longevity. Although little is known about regulatory mechanisms of petal senescence in flowers that show ethylene-independent senescence, a recent study of Japanese morning glory revealed that a NAC transcription factor, EPHEMERAL1 (EPH1), is a key regulator in ethylene-independent petal senescence...
January 2018: Breeding Science
https://www.readbyqxmd.com/read/29681447/acute-pancreatitis-in-a-patient-with-maple-syrup-urine-disease-a-management-paradox
#5
Nina B Gold, Jennifer A Blumenthal, Ann E Wessel, Deborah R Stein, Adam Scott, Victor L Fox, Amy Turner, Amy Kritzer, Farrah Rajabi, Katherine Peeler, Wen-Hann Tan
Maple syrup urine disease (MSUD) is an inborn error of metabolism that causes elevated leucine in the setting of acute illnesses. We describe an 8-year-old boy with MSUD who developed acute pancreatitis and subsequent leucinosis. This case highlights the complexities of fluid management in patients with MSUD.
April 19, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29680709/parkinson-s-disease-like-burst-firing-activity-in-subthalamic-nucleus-induced-by-aav-%C3%AE-synuclein-is-normalized-by-lrrk2-modulation
#6
Michael Aagaard Andersen, Kenneth Vielsted Christensen, Lassina Badolo, Garrick Paul Smith, Ross Jeggo, Poul Henning Jensen, Kathrine Just Andersen, Florence Sotty
Parkinson's disease (PD) affects motor function through degenerative processes and synaptic transmission impairments in the basal ganglia. None of the treatments available delays or stops the progression of the disease. While α-synuclein pathological accumulation represents a hallmark of the disease in its idiopathic form, leucine rich repeat kinase 2 (LRRK2) is genetically associated with familial and sporadic forms of PD. The genetic information suggests that LRRK2 kinase activity plays a role in the pathogenesis of the disease...
April 19, 2018: Neurobiology of Disease
https://www.readbyqxmd.com/read/29679865/generation-and-characterization-of-hagfish-variable-lymphocyte-receptor-b-against-glycoprotein-of-viral-hemorrhagic-septicemia-virus-vhsv
#7
Jung Seok Lee, Jaesung Kim, Se Pyeong Im, Si Won Kim, Jassy Mary S Lazarte, Jae Wook Jung, Tae Won Gong, Young Rim Kim, Jeong Ho Lee, Hyoung Jun Kim, Tae Sung Jung
Variable lymphocyte receptors B (VLRBs) are non-immunoglobulin components of the humoral immune system in jawless vertebrates including hagfish (Eptatretus burgeri) and lamprey (Petromyzon marinus). Hagfish VLRBs consist of leucine rich repeat (LRR) modules with a superhydrophobic C-terminal tail, the latter of which leads to extremely low expression levels in recombinant protein technology. Here, we present an artificially oligomerized VLRB (arVLRB) that conjugates via the C4bp oligomerization domain derived from human C4b-binding protein (hC4bp) rather than the superhydrophobic tail...
April 18, 2018: Molecular Immunology
https://www.readbyqxmd.com/read/29678858/the-receptor-like-kinase-atvrlk1-regulates-secondary-cell-wall-thickening
#8
Cheng Huang, Rui Zhang, Jinshan Gui, Yu Zhong, Laigeng Li
During the growth and development of land plants, some specialized cells, such as tracheary elements, undergo secondary cell wall thickening. Secondary cell walls contain additional lignin, compared with primary cell walls, thus providing mechanical strength and potentially improving defenses against pathogens. However, the molecular mechanisms that initiate wall thickening are unknown. In this study, we identified an Arabidopsis thaliana leucine-rich repeat receptor-like kinase, encoded by AtVRLK1 (Vascular-Related RLK 1), that is specifically expressed in cells undergoing secondary cell wall thickening...
April 20, 2018: Plant Physiology
https://www.readbyqxmd.com/read/29678544/influence-of-excipients-on-physical-and-aerosolization-stability-of-spray-dried-high-dose-powder-formulations-for-inhalation
#9
Nivedita Shetty, Heejun Park, Dmitry Zemlyanov, Sharad Mangal, Sonal Bhujbal, Qi Tony Zhou
The aim of this study is to investigate the influence of excipients on physical and aerosolization stability of spray dried Ciprofloxacin dry powder inhaler formulations. The model drug, Ciprofloxacin hydrochloride, was co-spray dried with excipients such as disaccharides (sucrose, lactose, trehalose), mannitol and L-leucine. The spray dried samples were stored at two different relative humidity (RH) conditions of: (1) 20% and (2) 55% RH at 20°C. Ciprofloxacin co-spray dried with disaccharides and L-leucine in the mass ratio of 1:1 demonstrated an increase in fine particle fraction (FPF) as compared with the spray dried Ciprofloxacin alone when stored at 20% RH...
April 17, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29677681/pphb22-a-member-of-hd-zip-proteins-activates-ppdam1-to-regulate-bud-dormancy-transition-in-suli-pear-pyrus-pyrifolia-white-pear-group
#10
Qinsong Yang, Qingfeng Niu, Jianzhao Li, Xiaoyan Zheng, Yunjing Ma, Songling Bai, Yuanwen Teng
Homeodomain-leucine zipper (HD-Zip) proteins, which form one of the largest and most diverse families, regulate many biological processes in plants, including differentiation, flowering, vascular development, and stress signaling. Abscisic acid (ABA) has been proved to be one of the key regulators of bud dormancy and to influence several HD-Zip genes expression. However, the role of HD-Zip genes in regulating bud dormancy remains unclear. We identified 47 pear (P. pyrifolia White Pear Group) HD-Zip genes, which were classified into four subfamilies (HD-Zip I-IV)...
April 5, 2018: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29676290/increased-expression-of-pelp1-in-human-sperm-is-correlated-with-decreased-semen-quality
#11
Izabela Skibinska, Miroslaw Andrusiewicz, Michal Soin, Magdalena Jendraszak, Paulina Urbaniak, Piotr Jedrzejczak, Malgorzata Kotwicka
Proline-, glutamic acid-, and leucine-rich protein 1 (PELP1) is a scaffolding protein involved in both genomic and nongenomic estrogen signal transduction pathways. To date, the role of PELP1 protein has yet to be characterized in human sperm and has not been associated with sperm parameters. To confirm the presence of PELP1 in human sperm, fresh semen samples were obtained from 178 donors. The study was designed to establish both mRNA and protein presence, and protein cellular localization. Additionally, the number of PELP1-positive spermatozoa was analyzed in men with normal and abnormal semen parameters...
April 20, 2018: Asian Journal of Andrology
https://www.readbyqxmd.com/read/29675572/baicalin-modulates-appl2-glucocorticoid-receptor-signaling-cascade-promotes-neurogenesis-and-attenuates-emotional-and-olfactory-dysfunctions-in-chronic-corticosterone-induced-depression
#12
Chong Gao, Qiaohui Du, Wenting Li, Ruixia Deng, Qi Wang, Aimin Xu, Jiangang Shen
Olfactory dysfunction is often accompanied with anxiety- and depressive-like behaviors in depressive patients. Impaired neurogenesis in hippocampus and subventricular zone (SVZ)-olfactory bulb (OB) contribute to anxiety- and depressive-like behaviors and olfactory dysfunctions. However, the underlying mechanisms of olfactory dysfunction remain unclear. Our previous study indicates that adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 (APPL2), could affect the activity and sensitivity of glucocorticoid receptor (GR) and mediate impaired hippocampal neurogenesis, which contribute the development of depression...
April 19, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29675568/effect-of-selenium-on-lipid-and-amino-acid-metabolism-in-yeast-cells
#13
Marek Kieliszek, Stanisław Błażejak, Anna Bzducha-Wróbel, Anna M Kot
This article discusses the effect of selenium in aqueous solutions on aspects of lipid and amino acid metabolism in the cell biomass of Saccharomyces cerevisiae MYA-2200 and Candida utilis ATCC 9950 yeasts. The yeast biomass was obtained by using waste products (potato wastewater and glycerol). Selenium, at a dose of 20 mg/L of aqueous solution, affected the differentiation of cellular morphology. Yeast enriched with selenium was characterized by a large functional diversity in terms of protein and amino acid content...
April 19, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29675451/cftr-modulates-wnt-%C3%AE-catenin-signaling-and-stem-cell-proliferation-in-murine-intestine
#14
Ashlee M Strubberg, Jinghua Liu, Nancy M Walker, Casey D Stefanski, R John MacLeod, Scott T Magness, Lane L Clarke
Background & Aims: Cystic fibrosis (CF) patients and CF mouse models have increased risk for gastrointestinal tumors. CF mice show augmented intestinal proliferation of unknown etiology and an altered intestinal environment. We examined the role of the cystic fibrosis transmembrane conductance regulator (Cftr) in Wnt/β-catenin signaling, stem cell proliferation, and its functional expression in the active intestinal stem cell (ISC) population. Dysregulation of intracellular pH (pHi ) in CF ISCs was investigated for facilitation of Wnt/β-catenin signaling...
March 2018: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29674953/salm-lrfn-family-synaptic-adhesion-molecules
#15
REVIEW
Eunkyung Lie, Yan Li, Ryunhee Kim, Eunjoon Kim
Synaptic adhesion-like molecules (SALMs) are a family of cell adhesion molecules involved in regulating neuronal and synapse development that have also been implicated in diverse brain dysfunctions, including autism spectrum disorders (ASDs). SALMs, also known as leucine-rich repeat (LRR) and fibronectin III domain-containing (LRFN) proteins, were originally identified as a group of novel adhesion-like molecules that contain LRRs in the extracellular region as well as a PDZ domain-binding tail that couples to PSD-95, an abundant excitatory postsynaptic scaffolding protein...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29674115/a-novel-l-leucine-5-hydroxylase-from-nostoc-piscinale-unravels-unexpected-sulfoxidation-activity-toward-l-methionine
#16
Dengyue Sun, Dengke Gao, Panpan Xu, Qianqian Guo, Zhangliang Zhu, Xiaotao Cheng, Song Bai, Hui-Min Qin, Fuping Lu
Hydroxy amino acids are produced by Fe(II)/αKG-dependent dioxygenases and used widely as medicinal intermediates for chemical synthesis. A novel l-leucine 5-hydroxylase gene from Nostoc piscinale (NpLDO) was cloned into pET28a (+), pColdI and pQE-80 L plasmids. Using a two-step purification process (Ni-affinity chromatography and gel filtration), highly purified recombinant NpLDO was obtained. Recombinant NpLDO displayed unexpectedly high sulfoxidation activity toward l-methionine. The reaction products were analyzed by high-performance liquid chromatography...
April 16, 2018: Protein Expression and Purification
https://www.readbyqxmd.com/read/29673542/maternal-nutritional-supplementation-with-fish-oil-and-or-leucine-improves-hepatic-function-and-antioxidant-defenses-and-minimizes-cachexia-indexes-in-walker-256-tumor-bearing-rats-offspring
#17
Natália Angelo da Silva Miyaguti, Sarah Christine Pereira de Oliveira, Maria Cristina Cintra Gomes-Marcondes
In this study, we hypothesized that throughout the pregnancy/weaning period, nutritional supplementation with leucine (which improves protein synthesis) and/or fish oil (rich in omega-3, which modulates oxidative stress) can minimize/improve cachexia-induced damage in rat offspring. Thus, we investigated the maternal supplementation with these nutrients over the modulation of cachexia index and liver function in tumor-bearing rats offspring. Pregnant rats were fed control, leucine, omega-3, and leucine/omega-3 diets, which were given throughout the gestational and weaning periods...
March 2018: Nutrition Research
https://www.readbyqxmd.com/read/29671916/assembly-and-annotation-of-a-draft-genome-sequence-for-glycine-latifolia-a-perennial-wild-relative-of-soybean
#18
Qiong Liu, Sungyul Chang, Glen L Hartman, Leslie L Domier
Glycine latifolia (Benth.) Newell & Hymowitz (2n=40), one of the 27 wild perennial relatives of soybean, possesses genetic diversity and agronomically favorable traits that are lacking in soybean. Here, we report the 939-Mb draft genome assembly of G. latifolia (PI 559298) using exclusively linked-reads sequenced from a single Chromium library. We organized scaffolds into 20 chromosome-scale pseudomolecules utilizing two genetic maps and the Glycine max (L.) Merr. genome sequence. High copy numbers of putative 91-bp centromere-specific tandem repeats were observed in consecutive blocks within predicted pericentromeric regions on several pseudomolecules...
April 19, 2018: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/29671767/effects-of-whey-protein-hydrolysate-ingestion-on-postprandial-aminoacidemia-compared-with-a-free-amino-acid-mixture-in-young-men
#19
Kyosuke Nakayama, Chiaki Sanbongi, Shuji Ikegami
To stimulate muscle protein synthesis, it is important to increase the plasma levels of essential amino acids (EAA), especially leucine, by ingesting proteins. Protein hydrolysate ingestion can induce postprandial hyperaminoacidemia; however, it is unclear whether protein hydrolysate is associated with higher levels of aminoacidemia compared with a free amino acid mixture when both are ingested orally. We assessed the effects of whey protein hydrolysate (WPH) ingestion on postprandial aminoacidemia, especially plasma leucine levels, compared to ingestion of a free amino acid mixture...
April 19, 2018: Nutrients
https://www.readbyqxmd.com/read/29671669/confirmation-and-refinement-of-the-heterozygous-deletion-of-the-small-leucine-rich-proteoglycans-associated-with-posterior-amorphous-corneal-dystrophy
#20
Aleck E Cervantes, Katherine M Gee, Martha F Whiting, Ricardo F Frausto, Anthony J Aldave
PURPOSE: To present the clinical and cytogenetic features of a previously unreported family with posterior amorphous corneal dystrophy (PACD) associated with a heterozygous deletion of the small leucine-rich proteoglycan (SRLP) genes on chromosome 12. METHODS: Clinical characterization was performed using slit lamp biomicroscopic and optical coherence tomography (OCT) imaging. Genomic DNA was collected from affected and unaffected family members, and a cytogenomic array was used to identify copy number variations (CNV) present in the PACD locus...
April 19, 2018: Ophthalmic Genetics
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