keyword
https://read.qxmd.com/read/38492509/metabolic-profile-of-phellodendron-amurense-rupr-in-vivo-of-rat-and-its-metabolomic-study-on-intervention-in-rheumatoid-arthritis
#1
JOURNAL ARTICLE
Ying Hao, Bingcheng Wang, Yuan Feng, Xiaodong Xin, Yawei Deng, Mingsong Liu, Chunhua Li, Shiqiao Liu, Qingqing Zhang
To analyze the metabolites (blood, urine and feces) in normal rats after intragastric administration of the decoction of Phellodendri Amurensis Cortex (PAC) and to map the metabolic profile of PAC in vivo of rat; meanwhile, to evaluate the anti-rheumatoid arthritis (RA) effect of PAC by blood metabolomics technique and to explore its mechanism. Performing on UPLC-Q-TOF-MS technology with a Waters ACQUITY UPLC BEH-C18 column (100 mm × 2.1 mm, 1.7 μm), the mobile phase was acetonitrile-0...
February 27, 2024: Journal of Pharmaceutical and Biomedical Analysis
https://read.qxmd.com/read/38491066/the-association-between-dietary-intake-of-branched-chain-amino-acids-and-odds-and-severity-of-rheumatoid-arthritis
#2
JOURNAL ARTICLE
Mohadeseh Soleimani Damaneh, Naheed Aryaeian, Shole Khajoenia, Leila Azadbakht, Fatemeh Sadat Hosseini-Baharanchi
This case-control study investigated the link between dietary branched-chain amino acids (BCAAs) and the risk and severity of rheumatoid arthritis (RA). We assessed dietary BCAA intake in 95 RA patients and 190 matched controls using a food frequency questionnaire. We also assessed the disease severity using the disease activity score 28 (DAS-28), ESR, VAS, morning stiffness, and tender and swollen joints. Higher BCAA intake, expressed as a percentage of total protein, was significantly associated with increased risk of RA for total BCAAs (OR 2...
March 15, 2024: Scientific Reports
https://read.qxmd.com/read/38490513/polymorphism-in-the-leucine-rich-repeats-of-tlr7-in-different-breeds-of-chicken-and-in-silico-analysis-of-its-effect-on-tlr7-structure-and-function
#3
JOURNAL ARTICLE
Abinaya Kaliappan, Saravanan Ramakrishnan, Prasad Thomas, Surya Kant Verma, Khushboo Panwar, Mithilesh Singh, Sohini Dey, Madhan Mohan Chellappa
Chicken toll-like receptor 7 (chTLR7) is a viral sensing pattern recognition receptor and detects ssRNA. The ligand binding site comprises leucine-rich repeats (LRRs) located in the ectodomain of chTLR7. Hence, any polymorphism in the binding site would modify its functional interaction with the ligand, resulting in varied strength of immune response. This study first aimed to compare the single nucleotide polymorphisms (SNPs) associated with the ligand binding site of TLR7 in three indigenous chicken breeds namely Aseel, Kadaknath, Nicobari along with an exotic breed White Leghorn...
March 13, 2024: Gene
https://read.qxmd.com/read/38490352/transgenerational-toxicity-induced-by-maternal-afb-1-exposure-in-caenorhabditis-elegans-associated-with-underlying-epigenetic-regulations
#4
JOURNAL ARTICLE
Hongyuan Zhou, Sirui Ren, Yulian Yang, Yuxian Qin, Ting Guo, Ying Zhou, Yuhao Zhang, Liang Ma
Aflatoxin B1 (AFB1 ), usually seriously contaminates in grain and oil foods or feed, displayed significant acute and chronic toxic effects in human and animal populations. However, little is known about the transgenerational toxic effects induced by a maternal AFB1 intake at a lower dose on offspring. In our study, only parental wild-type Caenorhabditis elegans was exposed to AFB1 (0-8 μg/ml) and the following three filial generations were grown on AFB1 -free NGM. Results showed that the toxic effects of AFB1 on the growth (body length) and reproduction (brood size, generation time and morphology of gonad arm) can be transmitted through generations...
March 13, 2024: Food and Chemical Toxicology
https://read.qxmd.com/read/38490066/the-opioid-peptide-leucine-enkephalin-modulates-hypothalamic-hypophysial-axis-in-the-cichlid-fish-oreochromis-mossambicus
#5
JOURNAL ARTICLE
Deepak Shinde, Shilpa K Bhat, C B Ganesh
In vertebrates, opioid peptides are thought to be involved in the regulation of reproduction; however, the significance of enkephalins in testicular function remains unclear. We examined the influence of δ-opioid receptor agonist leucine enkephalin (L-ENK) on the hypophysial-testicular axis of the cichlid fish Oreochromis mossambicus. Treatment with a low dose of L-ENK (60 µg) caused a significant increase in the numbers of primary and secondary spermatocytes and early and late spermatids, concomitant with intense immunolabelling of testicular androgen receptors, but did not significantly alter serum luteinizing hormone (LH) and 11-ketotestosterone (11-KT) levels compared to those of controls...
March 8, 2024: Animal Reproduction Science
https://read.qxmd.com/read/38489749/an-amino-acid-enabled-separator-for-effective-stabilization-of-li-anodes
#6
JOURNAL ARTICLE
Chenxu Wang, Lulu Ren, Chunhua Ying, Jin Liu, Wei-Hong Zhong
Fundamentally suppressing Li dendrite growth is known to be critical for realizing the potential high energy density for Li-metal batteries (LMBs). Inspired by the ionic transport function of proteins, we previously discovered that utilizing natural proteins was able to stabilize the Li anode but have not demonstrated how a specific amino acid of the protein enabled the function. In this study, we decorate the separator with Leucine ( Leu ) amino acid assisted by poly(acrylic acid) (PAA) for effectively stabilizing the Li-metal anode, so as to dramatically improve the cycling performance of LMBs...
March 15, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38489164/genome-wide-association-study-gwas-reveals-polygenic-architecture-for-limber-pine-quantitative-disease-resistance-to-white-pine-blister-rust
#7
JOURNAL ARTICLE
Jun-Jun Liu, Richard A Sniezko, Sydney Houston, Jodie Krakowski, Genoa Alger, Andy Benowicz, Robert Sissons, Arezoo Zamany, Holly Williams, Angelia Kegley, Benjamin Rancourt
Development of durable resistance effective against a broad range of pathotypes is crucial for restoration of pathogen-damaged ecosystems. This study dissected the complex genetic architecture for limber pine quantitative disease resistance (QDR) to Cronartium ribicola using a genome-wide association study (GWAS). Eighteen-month-old seedlings were inoculated for resistance screening under controlled conditions. Disease development was quantitatively assessed for QDR-related traits over four years post inoculation...
March 15, 2024: Phytopathology
https://read.qxmd.com/read/38488316/one-bite-sized-3d-printed-finger-foods-oriented-to-malnutrition-sarcopenia-and-frailty-prevention-in-the-older-people
#8
JOURNAL ARTICLE
Aušrinė Kurapkienė, Rimantė Vinauskienė, Ina Jasutienė, Gytė Damulevičienė, Jurgita Knašienė, Vita Lesauskaitė, Claire Sulmont-Rosse, Viktorija Eisinaitė, Daiva Leskauskaitė
BACKGROUND: In this study, innovative chocolate, citrus and mixture flavoured tofu-based nutritionally customized, dysphagia-oriented, comfortable-consumed, appetizing, one-bite sized finger foods, oriented to the malnutrition, sarcopenia, and frailty prevention in the older people were created by using 3D printing technology. Developed products were characterised by evaluating chemical composition, physical properties and performing sensory evaluation among geriatric clinic residents (≥60 years)...
March 15, 2024: Journal of the Science of Food and Agriculture
https://read.qxmd.com/read/38487927/natural-products-that-contain-higher-homologated-amino-acids
#9
JOURNAL ARTICLE
Skyler L Owens, Shopno R Ahmed, Rebecca M Lang, Laura E Stewart, Shogo Mori
This review focuses on discussing natural products (NPs) that contain higher homologs of amino acids (homoAAs) in the structure as well as the proposed and characterized biosynthesis of these non-proteinogenic amino acids. Homologation of amino acids includes the insertion of a methylene group into its side chain. It is not a very common modification found in NP biosynthesis as approximately 450 homoAA-containing NPs have been isolated from four bacterial phyla (Cyanobacteria, Actinomycetota, Myxococcota, and Pseudomonadota), two fungal phyla (Ascomycota and Basidiomycota), and one animal phylum (Porifera), except for a few examples...
March 15, 2024: Chembiochem: a European Journal of Chemical Biology
https://read.qxmd.com/read/38486709/visualizing-the-trans-synaptic-arrangement-of-synaptic-proteins-by-expansion-microscopy
#10
JOURNAL ARTICLE
Stefan Sachs, Sebastian Reinhard, Janna Eilts, Markus Sauer, Christian Werner
High fidelity synaptic neurotransmission in the millisecond range is provided by a defined structural arrangement of synaptic proteins. At the presynapse multi-epitope scaffolding proteins are organized spatially at release sites to guarantee optimal binding of neurotransmitters at receptor clusters. The organization of pre- and postsynaptic proteins in trans-synaptic nanocolumns would thus intuitively support efficient information transfer at the synapse. Visualization of these protein-dense regions as well as the minute size of protein-packed synaptic clefts remains, however, challenging...
2024: Frontiers in Cellular Neuroscience
https://read.qxmd.com/read/38486106/cancer-derived-exosomal-alu-rna-promotes-colorectal-cancer-progression
#11
JOURNAL ARTICLE
Sara Magliacane Trotta, Antonio Adinolfi, Luca D'Orsi, Sonia Panico, Grazia Mercadante, Patrick Mehlen, Jayakrishna Ambati, Sandro De Falco, Valeria Tarallo
Inflammation plays a crucial role in cancer progression, but the relevance of the inflammasome remains unclear. Alu RNA was the first endogenous nucleic acid shown to activate the NLRP3 (nucleotide-binding domain leucine-rich repeat containing 3) inflammasome. Here, we showed that Alu RNA can induce epithelial-to-mesenchymal transition (EMT) through NLRP3 inflammasome activation and IL-1β release in colorectal cancer (CRC) cells. Alu RNA is stored, transported and transferred to CRC cells by exosomes...
March 14, 2024: Experimental & Molecular Medicine
https://read.qxmd.com/read/38485609/cancer-associated-snps-in-bacteria-lessons-from-helicobacter-pylori
#12
REVIEW
Bodo Linz, Heinrich Sticht, Nicole Tegtmeyer, Steffen Backert
Several single-nucleotide polymorphisms (SNPs) in human chromosomes are known to predispose to cancer. However, cancer-associated SNPs in bacterial pathogens were unknown until discovered in the stomach pathogen Helicobacter pylori. Those include an alanine-threonine polymorphism in the EPIYA-B phosphorylation motif of the injected effector protein CagA that affects cancer risk by modifying inflammatory responses and loss of host cell polarity. A serine-to-leucine change in serine protease HtrA is associated with boosted proteolytic cleavage of epithelial junction proteins and introduction of DNA double-strand breaks (DSBs) in host chromosomes, which co-operatively elicit malignant alterations...
March 13, 2024: Trends in Microbiology
https://read.qxmd.com/read/38482164/effect-of-%C3%AE-alanine-on-the-athletic-performance-and-blood-amino-acid-metabolism-of-speed-racing-yili-horses
#13
JOURNAL ARTICLE
Xiaobin Li, Jun Ma, Haiying Li, Hai Li, Yuhui Ma, Haifeng Deng, Kailun Yang
The objective of this study was to examine the effects of supplemental β-alanine feeding on the athletic performance of Yili horses involved in speed racing, focusing on alterations in plasma free amino acid patterns pre and post exercise. Additionally, the research aimed to evaluate the effects of carnosine on the plasma acid-base buffering capacity and antioxidant levels in these horses. Twelve Yili horse stallions, averaging 3 years in age and 346.50 ± 21.39 kg in weight, were chosen and randomly divided into two groups: a control group and a test group, each comprising six horses...
2024: Frontiers in Veterinary Science
https://read.qxmd.com/read/38480885/substrate-induced-condensation-activates-plant-tir-domain-proteins
#14
JOURNAL ARTICLE
Wen Song, Li Liu, Dongli Yu, Hanna Bernardy, Jan Jirschitzka, Shijia Huang, Aolin Jia, Wictoria Jemielniak, Julia Acker, Henriette Laessle, Junli Wang, Qiaochu Shen, Weijie Chen, Pilong Li, Jane E Parker, Zhifu Han, Paul Schulze-Lefert, Jijie Chai
Plant nucleotide-binding leucine-rich repeat (NLR) immune receptors with an N-terminal Toll/interleukin-1 receptor (TIR) domain mediate recognition of strain-specific pathogen effectors, typically via their C-terminal ligand-sensing domains1 . Effector binding enables TIR-encoded enzymatic activities that are required for TIR-NLR (TNL)-mediated immunity2,3 . Many truncated TNL proteins lack effector-sensing domains but retain similar enzymatic and immune activities4,5 . The mechanism underlying the activation of these TIR domain proteins remain unclear...
March 13, 2024: Nature
https://read.qxmd.com/read/38479028/tear-metabolomics-for-the-diagnosis-of-primary-open-angle-glaucoma
#15
JOURNAL ARTICLE
Marina Botello-Marabotto, M Carmen Martínez-Bisbal, M Dolores Pinazo-Durán, Ramón Martínez-Máñez
Primary Open-Angle Glaucoma (POAG) is the most prevalent glaucoma type, and the leading cause of irreversible visual impairment and blindness worldwide. Identification of early POAG biomarkers is of enormous value, as there is not an effective treatment for the glaucomatous optic nerve degeneration (OND). In this pilot study, a metabolomic analysis, by using proton (1 H) nuclear magnetic resonance (NMR) spectroscopy was conducted in tears, in order to determine the changes of specific metabolites in the initial glaucoma eyes and to discover potential diagnostic biomarkers...
February 25, 2024: Talanta
https://read.qxmd.com/read/38477690/development-of-an-easy-to-set-up-multiple-heart-cutting-achiral-chiral-lc-lc-method-for-the-analysis-of-branched-chain-amino-acids-in-commercial-tablets
#16
JOURNAL ARTICLE
Ina Varfaj, Ghaid W A Abualzulof, Simone Moretti, Anna Migni, Irene Uda, Laura Goracci, Federica Ianni, Andrea Carotti, Roccaldo Sardella
In this paper, the development and application of a multiple heart-cutting achiral-chiral LC-LC method (mLC-LC) for the analysis of dansylated (Dns) branched-chain amino acids in commercial tablets are described. In the first dimension, a Waters Xbridge RP C18 achiral column was used under gradient conditions with buffered aqueous solution and acetonitrile. The elution order Dns-valine (Dns-Val) < Dns-isoleucine (Dns-Ile) < Dns-leucine (Dns-Leu) turned out with full resolution between adjacent peaks: 7...
March 13, 2024: Electrophoresis
https://read.qxmd.com/read/38477642/batf-promotes-extramedullary-infiltration-through-tgf-%C3%AE-1-smad-mmps-axis-in-acute-myeloid-leukemia
#17
JOURNAL ARTICLE
Ru Zhang, Jiyu Miao, Meng Zhai, Rui Liu, Fangmei Li, Xuezhu Xu, Lingjuan Huang, Ting Wang, Rui Yang, Ruoyu Yang, Yiwen Wang, Aili He, Jianli Wang
Acute myeloid leukemia (AML) is one of the most prevalent types of leukemia and is challenging to cure for most patients. Basic Leucine Zipper ATF-Like Transcription Factor (BATF) has been reported to participate in the development and progression of numerous tumors. However, its role in AML is largely unknown. In this study, the expression and prognostic value of BATF were examined in AML. Our results demonstrated that BATF expression was upregulated in AML patients, which was significantly correlated with poor clinical characteristics and survival...
March 13, 2024: Molecular Carcinogenesis
https://read.qxmd.com/read/38477420/lrrk2-regulates-ferroptosis-through-the-system-xc-gsh-gpx4-pathway-in-the-neuroinflammatory-mechanism-of-parkinson-s-disease
#18
JOURNAL ARTICLE
Zijian Zheng, Shushan Zhang, Xinjie Liu, Xiangrong Wang, Cheng Xue, Xiao Wu, Xinran Zhang, Xinping Xu, Zheng Liu, Longping Yao, Guohui Lu
Parkinson's disease (PD) is the most prevalent neurodegenerative disorder. Neuroinflammation mediated by activated microglia and apoptosis of dopaminergic (DA) neurons in the midbrain are its primary pathological manifestations. Leucine-rich repeat protein kinase 2 (LRRK2) kinase has been observed to increase expression during neuroinflammation, however, the effect of LRRK2 on microglia activation remains poorly understood. In this study, we have established lipopolysaccharide (LPS) treated BV2 cells and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) models for both in vivo and in vitro investigation...
March 13, 2024: Journal of Cellular Physiology
https://read.qxmd.com/read/38477306/evaluation-of-individual-variation-of-d-amino-acids-in-human-plasma-by-a-two-dimensional-lc-ms-ms-system-and-application-to-the-early-diagnosis-of-chronic-kidney-disease
#19
JOURNAL ARTICLE
Chiharu Ishii, Takeyuki Akita, Tomonori Kimura, Shinsuke Sakai, Masashi Mita, Tomomi Ide, Yoshitaka Isaka, Kenji Hamase
For the discovery of sensitive biomarkers of kidney function focusing on chiral amino acids, a multiple heart-cutting two-dimensional (2D) liquid chromatography-mass spectrometry (LC-MS)/MS system has been designed/developed. As the target analytes, alanine (Ala), aspartic acid, glutamic acid (Glu), leucine (Leu), lysine, methionine, phenylalanine (Phe), proline (Pro), serine (Ser), and valine were selected considering the presence of their d-forms in mammals. The 2D LC-MS/MS system consisted of the nonenantioselective reversed-phase separation of the target amino acids, the separations of the d- and l-enantiomers, and detection using MS/MS...
March 13, 2024: Analytical Chemistry
https://read.qxmd.com/read/38476461/lrrc25-expression-during-physiological-aging-and-in-mouse-models-of-alzheimer-s-disease-and-ipsc-derived-neurons
#20
JOURNAL ARTICLE
Dinesh Devadoss, Juliet Akkaoui, Madhavan Nair, Madepalli K Lakshmana
The leucine-rich repeat-containing protein 25 (LRRC25) is relatively a novel protein with no information on its role in neuronal or brain function. A recent study suggested LRRC25 is a potential risk factor for Alzheimer's disease (AD). As a first step to understanding LRRC25's role in the brain and AD, we found LRRC25 is expressed in both cell membranes and cytoplasm in a punctuate appearance in astrocytes, microglia, and neurons in cell lines as well as mouse brain. We also found that LRRC25 expression is both age- and brain region-dependent and that 1-day-old (1D) pups expressed the least amount of LRRC25 protein compared to adult ages...
2024: Frontiers in Molecular Neuroscience
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