Wen Song, Li Liu, Dongli Yu, Hanna Bernardy, Jan Jirschitzka, Shijia Huang, Aolin Jia, Wictoria Jemielniak, Julia Acker, Henriette Laessle, Junli Wang, Qiaochu Shen, Weijie Chen, Pilong Li, Jane E Parker, Zhifu Han, Paul Schulze-Lefert, Jijie Chai
Plant nucleotide-binding leucine-rich repeat (NLR) immune receptors with an N-terminal Toll/interleukin-1 receptor (TIR) domain mediate recognition of strain-specific pathogen effectors, typically via their C-terminal ligand-sensing domains1 . Effector binding enables TIR-encoded enzymatic activities that are required for TIR-NLR (TNL)-mediated immunity2,3 . Many truncated TNL proteins lack effector-sensing domains but retain similar enzymatic and immune activities4,5 . The mechanism underlying the activation of these TIR domain proteins remain unclear...
March 13, 2024: Nature