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JOURNAL ARTICLE
Xue-Wei Wang, Shu-Guang Yang, Ming-Wen Hu, Rui-Ying Wang, Chi Zhang, Anish R Kosanam, Arinze J Ochuba, Jing-Jing Jiang, Ximei Luo, Yun Guan, Jiang Qian, Chang-Mei Liu, Feng-Quan Zhou
Current treatments for neurodegenerative diseases and neural injuries face major challenges, primarily due to the diminished regenerative capacity of neurons in the mammalian central nervous system (CNS) as they mature. Here, we investigated the role of Ezh2, a histone methyltransferase, in regulating mammalian axon regeneration. We found that Ezh2 declined in the mouse nervous system during maturation but was upregulated in adult dorsal root ganglion neurons following peripheral nerve injury to facilitate spontaneous axon regeneration...
November 28, 2023: Journal of Clinical Investigation
#22
JOURNAL ARTICLE
Ann L Webber, Melinda Toomey, Lisa Keay, Shuan Dai, Glen A Gole, Dana Newcomb, Lynne McKinlay
PURPOSE: The Queensland Children's Hospital Paediatric Optometry Alignment Program commenced with a pilot phase to assess its feasibility, effectiveness and acceptability. This study identified the barriers that hinder effective interprofessional collaboration and the facilitators that contribute to its success, and assessed changes in optometrists' satisfaction since the pilot phase of the collaborative care programme. METHODS: Qualitative deductive and inductive content analysis was applied to open-ended free-text survey responses collected in 2018 from the optometrists involved in the Program's pilot phase...
November 27, 2023: Ophthalmic & Physiological Optics: the Journal of the British College of Ophthalmic Opticians (Optometrists)
#23
REVIEW
Mayank Choubey, Munichandra B Tirumalasetty, Nalini S Bora, Puran S Bora
In recent years, there has been a captivating focus of interest in elucidating the intricate crosstalk between adiponectin (APN), a versatile fat-associated adipokine and ocular pathologies. Unveiling the intricate relationship between adipocytokine APN and its receptors (AdipoRs) with aging eye disorders has emerged as a fascinating frontier in medical research. This review article delves into this connection, illuminating the hidden influence of APN on retinal health. This comprehensive review critically examines the latest findings and breakthroughs that underscore the pivotal roles of APN/AdipoRs signaling in maintaining ocular homeostasis and protecting against eye ailments...
November 14, 2023: Biomedicines
#24
EDITORIAL
Bharat Gurnani, Kirandeep Kaur
In recent years, the advent of artificial intelligence (AI) has transformed many sectors, including medical education. This editorial critically appraises the integration of ChatGPT, a state-of-the-art AI language model, into ophthalmic education, focusing on its potential, limitations, and ethical considerations. The application of ChatGPT in teaching and training ophthalmologists presents an innovative method to offer real-time, customized learning experiences. Through a systematic analysis of both experimental and clinical data, this editorial examines how ChatGPT enhances engagement, understanding, and retention of complex ophthalmological concepts...
November 16, 2023: European Journal of Ophthalmology
#25
JOURNAL ARTICLE
Jesse L Berry, Sarah Pike, Archeta Rajagopalan, Mark W Reid, Ido Didi Fabian
PURPOSE: Globally, disparities exist in retinoblastoma treatment outcomes between high- and low-income countries, but independent analysis of American countries is lacking. We report outcomes of American retinoblastoma patients and explore factors associated with survival and globe salvage. DESIGN: Subanalysis of prospective cohort study data. METHODS: Multicenter analysis at 57 American treatment centers in 23 countries of varying economic levels (low income [LIC], lower-middle income [LMIC], upper-middle income [UMIC], and high income [HIC]) of 491 treatment-naïve retinoblastoma patients diagnosed in 2017 and followed through 2020...
November 10, 2023: American Journal of Ophthalmology
#26
JOURNAL ARTICLE
Ahmad M Mansour, Lorenzo López-Guajardo, Silvana Belotto, Luiz H Lima, Abdul Razzak Charbaji, Stephen G Schwartz, Lihteh Wu, William E Smiddy, Javier Ascaso, Ignasi Jürgens, Robert E Foster, Ayman G Elnahry, Suthasinee Sinawat, Isabel Pinilla, Eduardo Pérez-Salvador García, Marta Suarez Leoz, Nuria Olivier Pascual, Lucas Zago Ribeiro, Rosa Arroyo Castillo, Amparo Navea, Sibel Kadayifcilar, Abdallah A Ellabban, Amanda Rey, Hana A Mansour, Koushik Tripathy, Igor Kozak, Sami H Uwaydat, María Sacramento Valero, Rosario Cobo-Soriano, María Dolores Díaz-Barreda, Laura Monje Fernández, Fernando González Del Valle, Irene López Liroz, Erika Vazquez Cruchaga, Alex Fonollosa, Olivia Esteban Floria, Maria Isabel Relimpio Lopez, Gaurav Shah, Maxwell J Wingelaar, Raghav Ravani, Juan Donate-López, Elena Rubio Velázquez, Maurizio Parodi
PURPOSE: To investigate best corrected visual acuity (BCVA), subretinal fluid (SRF) absorption time or ellipsoid zone (EZ) restoration time and various variables in patients with persistent SRF after successful primary repair of rhegmatogenous retinal detachment (RRD). METHODS: This retrospective multicenter study allowed independent analysis of the healing pattern by two observers based on composite of serial cross-sectional macular optical coherence tomography (OCT) scans...
October 30, 2023: European Journal of Ophthalmology
#27
JOURNAL ARTICLE
Anna Borelli, Jordan Behr, Maria Ruggeri, Mini Han, Yujia Zhou, C Stephen Foster
BACKGROUND: Behcet disease is a systemic vasculitis, which may involve the eyes and central nervous system. The true prevalence of neurological involvement is not precisely known but may be associated with ocular involvement. This study investigates the association between Behcet uveitis and neuro-Behcet disease. METHODS: A retrospective single-center analysis was conducted for consecutive patients with Behcet uveitis at the Massachusetts Eye Research and Surgery Institution...
October 16, 2023: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
#28
JOURNAL ARTICLE
Shahin Hallaj, Sagar J Shah, Eli K Cehelyk, Lauren E Hock, Daniel Lee, Reza Razeghinejad, Jonathan S Myers, Rosemary Frasso, Natasha Nayak Kolomeyer
PURPOSE: Attempts at engaging relatives of glaucoma patients in education and screening have had limited success. This study explores the feasibility of an electronic intervention to facilitate direct yet reliable glaucoma risk communication between open-angle glaucoma patients (probands) and their first-degree relatives (FDRs). DESIGN: Prospective survey and assessment of intervention. PARTICIPANTS: 50 adult probands, engaging 140 FDRs. METHODS, INTERVENTION, OR TESTING: Phase I was an iterative process involving creating a customized website and Quick Response (QR)-code-based intervention designed with input from probands, FDRs of patients, community members, and researchers...
October 12, 2023: Ophthalmology Glaucoma
#29
JOURNAL ARTICLE
Elizabeth D Hodges, Paul W Chrystal, Tim Footz, Lance P Doucette, Nicole C L Noel, Zixuan Li, Michael A Walter, W Ted Allison
Pigmentary glaucoma has recently been associated with missense mutations in PMEL that are dominantly inherited and enriched in the protein's fascinating repeat domain. PMEL pathobiology is intriguing because PMEL forms functional amyloid in healthy eyes, and this PMEL amyloid acts to scaffold melanin deposition. This is an informative contradistinction to prominent neurodegenerative diseases where amyloid formation is neurotoxic and mutations cause a toxic gain of function called "amyloidosis". Preclinical animal models have failed to model this PMEL "dysamyloidosis" pathomechanism and instead cause recessively inherited ocular pigment defects via PMEL loss of function; they have not addressed the consequences of disrupting PMEL's repetitive region...
September 22, 2023: International Journal of Molecular Sciences
#30
JOURNAL ARTICLE
L L Wang
In recent years, precision minimally invasive surgery has emerged as a significant developmental direction within the field of ophthalmology, bringing about revolutionary changes in the treatment of corneal diseases. Employing cutting-edge techniques and surgical methods, corneal surgeries have achieved greater precision and safety. In cases such as immune-mediated corneal diseases, it remains crucial to underscore the enhancement of vision through minimally invasive surgical approaches, thereby avoiding potential irreversible complications that surgery might induce...
October 11, 2023: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
#31
JOURNAL ARTICLE
Augusto Azuara-Blanco, John G Lawrenson, Anthony J King, Paul J Foster, Gianni Virgili, Mary Guiney, Winnie Nolan, Anish Jindal, Meenakshi Sharma, Ciaran O'Neill, Christopher R Cardwell, Mike Clarke
INTRODUCTION: Angle-closure is responsible for half of all glaucoma blindness globally. Patients with suspected glaucoma require assessment of the drainage angle by an experienced clinician. The goal of this study is to evaluate the diagnostic performance and cost-effectiveness of two non-contact tests, anterior segment OCT (Optical Coherence Tomography) (AS-OCT) and limbal anterior chamber depth for patients referred to hospital with suspected angle closure compared with gonioscopy by ophthalmologist...
October 4, 2023: BMJ Open
#32
JOURNAL ARTICLE
Karen Eden, Kathie Doliszny, Rohit Shukla, Julia Foster, Mark Bona
OBJECTIVE: To investigate the effect of the South East Ontario Vision Rehabilitation Service (SOVRS), a centrally administered, regionally delivered vision rehabilitation service, on access to vision rehabilitation care. DESIGN: Pre-implementation (n = 1196) and post-implementation (n = 414) observational study. PARTICIPANTS: Patients referred for low-vision assessment at the hospital-based Kingston Health Sciences Centre Vision Rehabilitation Clinic and community-based Southeastern Vision Loss Rehabilitation Ontario clinics from 2014 to 2019...
September 21, 2023: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
#33
COMMENT
Alan Kastner, Kelsey V Stuart, Giovanni Montesano, C Gustavo De Moraes, Jae H Kang, Janey L Wiggs, Louis R Pasquale, Pirro Hysi, Sharon Y L Chua, Praveen J Patel, Paul J Foster, Peng T Khaw, Anthony P Khawaja
IMPORTANCE: Calcium channel blocker (CCB) use has been associated with an increased risk of glaucoma in exploratory studies. OBJECTIVE: To examine the association of systemic CCB use with glaucoma and related traits among UK Biobank participants. DESIGN, SETTING, AND PARTICIPANTS: This population-based cross-sectional study included UK Biobank participants with complete data (2006-2010) for analysis of glaucoma status, intraocular pressure (IOP), and optical coherence tomography (OCT)-derived inner retinal layer thicknesses...
October 1, 2023: JAMA Ophthalmology
#34
JOURNAL ARTICLE
Andrew H Dolinko, Diana Edem Morvey, Shimy Apoorva, Max Chikovsky, Stephen D Anesi, C Stephen Foster
PURPOSE: To describe the course of care and outcomes for 3 uveitis patients formerly on Remicade that were non-medically switched to Inflectra. DESIGN: Retrospective observational case series. METHODS: • Setting: Tertiary care clinical practice.• Patient population: 3 Uveitis patients, observing both eyes for inflammation as applicable. Patients included if they had been on Inflectra for ≥2 infusions and history of Remicade use...
September 6, 2023: European Journal of Ophthalmology
#35
JOURNAL ARTICLE
Suzanne K Freitag, Vinay K Aakalu, Jill A Foster, Timothy J McCulley, Jeremiah P Tao, M Reza Vagefi, Michael T Yen, Stephen J Kim, Edward J Wladis
PURPOSE: To review the literature on the adjuvant use of mitomycin C (MMC) during dacryocystorhinostomy (DCR) in adults with primary nasolacrimal duct obstructions (NLDOs) to determine the efficacy in improving functional and anatomic outcomes with an acceptable level of risk. METHODS: A literature search conducted in November 2020 and updated in November 2022 yielded 137 articles. Twenty-four articles met the inclusion criteria and were rated for level of evidence by the panel methodologist...
November 2023: Ophthalmology
#36
Jiang Qian, Cheng Qian, Ying Xin, Cheng Qi, Hui Wang, Donald Zack, Seth Blackshaw, Samer Hattar, Feng-Quan Zhou
The progressive death of mature neurons often results in neurodegenerative diseases. While the previous studies have mostly focused on identifying intrinsic mechanisms controlling neuronal survival, the extracellular environment also plays a critical role in regulating cell viability. Here we explore how intercellular communication contributes to the survival of retinal ganglion cells (RGCs) following the optic nerve crush (ONC). Although the direct effect of the ONC is restricted to the RGCs, we observed transcriptomic responses in other retinal cells to the injury based on the single-cell RNA-seq, with astrocytes and Müller glia having the most interactions with RGCs...
August 17, 2023: Research Square
#37
REVIEW
Jeremiah P Tao, Joanne F Shen, Vinay K Aakalu, Jill A Foster, Suzanne K Freitag, Timothy J McCulley, M Reza Vagefi, Stephen J Kim, Edward J Wladis
PURPOSE: To review the literature to determine the efficacy and safety of thermal pulsation technologies in improving signs or symptoms of meibomian gland dysfunction (MGD) and dry eye compared with no therapy or with conventional warm compress therapy or eyelid hygiene. METHODS: A literature search was conducted in the PubMed database in June 2022 and again in March 2023 to identify all studies in the English language on the use of thermal pulsation to treat MGD or dry eye...
December 2023: Ophthalmology
#38
JOURNAL ARTICLE
Piotr Musialek, Leo H Bonati, Richard Bulbulia, Alison Halliday, Birgit Bock, Laura Capoccia, Hans-Henning Eckstein, Iris Q Grunwald, Peck Lin Lip, Andre Monteiro, Kosmas I Paraskevas, Anna Podlasek, Barbara Rantner, Kenneth Rosenfield, Adnan H Siddiqui, Henrik Sillesen, Isabelle Van Herzeele, Tomasz J Guzik, Lucia Mazzolai, Victor Aboyans, Gregory Y H Lip
Carotid atherosclerotic disease continues to be an important cause of stroke, often disabling or fatal. Such strokes could be largely prevented through optimal medical therapy and carotid revascularization. Advancements in discovery research and imaging along with evidence from recent pharmacology and interventional clinical trials and registries and the progress in acute stroke management have markedly expanded knowledge base for clinical decisions in carotid stenosis. Nevertheless, there is variability in carotid-related stroke prevention and management strategies across medical specialities...
August 25, 2023: Cardiovascular Research
#39
JOURNAL ARTICLE
Sayuri Sekimitsu, David Xiang, Sophie Lloyd Smith, Katie Curran, Tobias Elze, David S Friedman, Paul J Foster, Yuyang Luo, Louis R Pasquale, Tunde Peto, Ayellet V Segrè, Yusrah Shweikh, Alasdair Warwick, Yan Zhao, Janey L Wiggs, Nazlee Zebardast
IMPORTANCE: Better understanding of primary open-angle glaucoma (POAG) genetics could enable timely screening and promote individualized disease risk prognostication. OBJECTIVE: To evaluate phenotypic features across genetic burden for POAG. DESIGN, SETTING, AND PARTICIPANTS: This was a cross-sectional, population-based study conducted from 2006 to 2010. Included participants were individuals from the UK Biobank aged 40 to 69 years. Individuals with non-POAG forms of glaucoma were excluded from the analysis...
August 17, 2023: JAMA Ophthalmology
#40
JOURNAL ARTICLE
Grace S Yin, Frank van der Heide, Thomas J Littlejohns, Elżbieta Kuźma, Shabina Hayat, Carol Brayne, Paul J Foster, Robert Luben, Anthony P Khawaja
BACKGROUND: Retinal nerve fiber layer (RNFL) thickness may reflect cerebral status. OBJECTIVE: This study assessed the relationship between RNFL thickness and incident all-cause dementia in the European Prospective Investigation into Cancer in Norfolk (EPIC-Norfolk) Eye Study. METHODS: Glaucoma detection with variable corneal compensation (GDx-VCC) and Heidelberg Retinal Tomograph II (HRT II) derived global mean RNFL thickness from dementia-free participants at baseline within the EPIC-Norfolk Eye Study were analyzed...
August 9, 2023: Journal of Alzheimer's Disease: JAD
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