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Foster glaucoma or ophthalmology

Jonathan Clarke, Renata Puertas, Aachal Kotecha, Paul J Foster, Keith Barton
BACKGROUND/AIMS: To examine the agreement in clinical decisions of glaucoma status made in a virtual glaucoma clinic with those made during a face-to-face consultation. METHODS: A trained nurse and technicians entered data prospectively for 204 patients into a proforma. A subsequent face-to-face clinical assessment was completed by either a glaucoma consultant or fellow. Proformas were reviewed remotely by one of two additional glaucoma consultants, and 12 months later, by the clinicians who had undertaken the original clinical examination...
October 11, 2016: British Journal of Ophthalmology
Fang Ko, Paul J Foster, Nicholas G Strouthidis, Yusrah Shweikh, Qi Yang, Charles A Reisman, Zaynah A Muthy, Usha Chakravarthy, Andrew J Lotery, Pearse A Keane, Adnan Tufail, Carlota M Grossi, Praveen J Patel
PURPOSE: To describe associations of ocular and systemic factors with retinal pigment epithelium (RPE)-Bruch's membrane (BM) complex thickness as measured by spectral-domain (SD) optical coherence tomography (OCT). DESIGN: Multisite community-based study. This research has been conducted using the UK Biobank Resource. PARTICIPANTS: Sixty-seven thousand three hundred eighteen people 40 to 69 years old received questionnaires, physical examination, and eye examination, including macular SD OCT...
October 6, 2016: Ophthalmology
Augusto Azuara-Blanco, Jennifer Burr, Craig Ramsay, David Cooper, Paul J Foster, David S Friedman, Graham Scotland, Mehdi Javanbakht, Claire Cochrane, John Norrie
BACKGROUND: Primary angle-closure glaucoma is a leading cause of irreversible blindness worldwide. In early-stage disease, intraocular pressure is raised without visual loss. Because the crystalline lens has a major mechanistic role, lens extraction might be a useful initial treatment. METHODS: From Jan 8, 2009, to Dec 28, 2011, we enrolled patients from 30 hospital eye services in five countries. Randomisation was done by a web-based application. Patients were assigned to undergo clear-lens extraction or receive standard care with laser peripheral iridotomy and topical medical treatment...
October 1, 2016: Lancet
Danny Mitry, Kris Zutis, Baljean Dhillon, Tunde Peto, Shabina Hayat, Kay-Tee Khaw, James E Morgan, Wendy Moncur, Emanuele Trucco, Paul J Foster
PURPOSE: Crowdsourcing is based on outsourcing computationally intensive tasks to numerous individuals in the online community who have no formal training. Our aim was to develop a novel online tool designed to facilitate large-scale annotation of digital retinal images, and to assess the accuracy of crowdsource grading using this tool, comparing it to expert classification. METHODS: We used 100 retinal fundus photograph images with predetermined disease criteria selected by two experts from a large cohort study...
September 2016: Translational Vision Science & Technology
Anthony P Khawaja, Henriët Springelkamp, Catherine Creuzot-Garcher, Cécile Delcourt, Albert Hofman, René Höhn, Adriana I Iglesias, Roger C W Wolfs, Jean-François Korobelnik, Rufino Silva, Fotis Topouzis, Katie M Williams, Alain M Bron, Gabriëlle H S Buitendijk, Maria da Luz Cachulo, Audrey Cougnard-Grégoire, Jean-François Dartigues, Christopher J Hammond, Norbert Pfeiffer, Angeliki Salonikiou, Cornelia M van Duijn, Johannes R Vingerling, Robert N Luben, Alireza Mirshahi, Julia Lamparter, Caroline C W Klaver, Nomdo M Jansonius, Paul J Foster
Raised intraocular pressure (IOP) is the most important risk factor for developing glaucoma, the second commonest cause of blindness globally. Understanding associations with IOP and variations in IOP between countries may teach us about mechanisms underlying glaucoma. We examined cross-sectional associations with IOP in 43,500 European adults from 12 cohort studies belonging to the European Eye Epidemiology (E(3)) consortium. Each study conducted multivariable linear regression with IOP as the outcome variable and results were pooled using random effects meta-analysis...
September 9, 2016: European Journal of Epidemiology
Arash Maleki, Robert T Swan, Andres F Lasave, Lina Ma, C Stephen Foster
No abstract text is available yet for this article.
September 1, 2016: Ophthalmology
Soumendra Sahoo
BACKGROUND: To know the individual's current level of readiness and to manage self-directed learning (SDL) not only help learners but also the instructors. The objectives of this study were to find SDL readiness among 4(th) year medical student and to analyze the effect of weekly assessment of SDL topics. METHODOLOGY: This was a cross-sectional study to analyze the effect of weekly assessment of SDL topics in fostering SDL. The 51 4(th) year students during a clinical posting in ophthalmology participated for this study...
July 2016: International Journal of Applied and Basic Medical Research
Claude Pinnock, Jennifer L Y Yip, Anthony P Khawaja, Robert Luben, Shabina Hayat, David C Broadway, Paul J Foster, Kay-Tee Khaw, Nick Wareham
PURPOSE: To determine if topical beta-blocker use is associated with increased cardiovascular mortality, particularly among people with self-reported glaucoma. METHODS: All participants who participated in the first health check (N = 25,639) of the European Prospective Investigation into Cancer (EPIC) Norfolk cohort (1993-2013) were included in this prospective cohort study, with a median follow-up of 17.0 years. We determined use of topical beta-blockers at baseline through a self-reported questionnaire and prescription check at the first clinical visit...
October 2016: Ophthalmic Epidemiology
Suzanne T Anderson, Lois M Nora, Christine W McEntee, Matthew E Fitzgerald, Samantha Guastella Nugent
The mission of the American Board of Ophthalmology (ABO) is to serve the public by improving the quality of ophthalmic practice through a continuing certification process that fosters excellence and encourages continual learning. Since 2001, achieving this mission has been enhanced by including public directors in the ABO governance. We review the evolution of including nonprofessional members on the governing boards of professional regulatory and self-regulatory organizations generally, provide history about the incorporation of non-professional public directors into the governance structure of the American Board of Medical Specialties and the ABO, and offer insights about the perceived impact of public directors on the ABO...
September 2016: Ophthalmology
C F Amaral, J M Cordeiro, T C S Emídio, A G C Presotto, C M R Barbosa
The absence of the eyeball can generate psychosocial and facial harmony changes, such as atrophy of the muscles around it. In these cases, the use of an orthostatic prosthesis with expanding function fosters distension of the tissues for subsequent rehabilitation. This technique consists of making individual ocular prostheses with gradual enlargement of size. The aim of this following clinical report was to describe the technique used in the standing prosthetic rehabilitation of a patient, 73 years old, who underwent enucleation of the right eye as a result of glaucoma...
October 2016: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
Ursula Staubli, Natalie Rangel-Diaz, Miguel Alcantara, Yong-Xin Li, Jia-Ying Yang, Kai-Ming Zhang, Alan C Foster
The NMDA subtype of glutamate receptor and its co-agonist d-serine play a key role in synaptic function in the central nervous system (CNS), including visual cortex and retina. In retinal diseases such as glaucoma and macular degeneration, a loss of vision arises from malfunction of retinal cells, resulting in a glutamate hypofunctional state along the visual pathway in the affected parts of the visual field. An effective strategy to remedy this loss of function might be to increase extracellular levels of d-serine and thereby boost synaptic NMDA receptor-mediated visual transmission and/or plasticity to compensate for the impairment...
October 2016: Vision Research
Swetha Dhanireddy, Ninani C Kombo, Abhishek R Payal, Clovis Arcoverde Freitas-Neto, Janine Preble, C Stephen Foster
PURPOSE: To evaluate the outcomes of the Ex-PRESS Filtration Device in patients with uveitic glaucoma. METHODS: We reviewed 23 eyes, comparing control simple glaucoma patients (n = 11) to uveitic glaucoma patients (n = 12). Intraocular pressure (IOP) and glaucoma medications at the preoperative examination were compared with those at the 6-month and 10-14-month postoperative examination. Surgical success was defined as ≥25% decrease in intraocular pressure without hypotony, and/or decrease in glaucoma medications at 6 months follow-up...
May 26, 2016: Ocular Immunology and Inflammation
Evan S Caplan, Aaron S Kesselheim
Vascular endothelial growth factor (VEGF) inhibitors have revolutionized the care of vasoproliferative ophthalmologic disease and their history can provide insights into transformative drug development. Experts involved in the basic science through clinical development of VEGF inhibitors were interviewed and interviews were analyzed to synthesize key themes. Extensive basic science investigations by a multidisciplinary network of scientists and clinicians, most affiliated with Harvard Medical School, over the course of decades enabled a deep understanding of VEGF...
June 2016: Drug Discovery Today
Ana M Suelves, Neerav Lamba, Halea K Meese, C Stephen Foster, Jesus Maria González-Martín, Manuel Díaz-Llopis, William G Christen
PURPOSE: To analyze factors predictive of having treatment-resistant uveitis in patients with juvenile idiopathic arthritis (JIA)-associated uveitis. METHODS: The medical records of patients diagnosed with JIA-associated uveitis treated at a single tertiary referral center from October 2005 to March 2013 were reviewed retrospectively. The main outcome measures were demographic characteristics, ocular comorbidity, clinical course, treatments, and baseline risk factors associated with poor response to first-line therapies...
June 2016: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
Sukhum Silpa-Archa, Joan J Lee, Sutasinee Boonsopon, Marisol T Lizárraga, Janine M Preble, Dusit Sujirarat, Pranav Patel, C Stephen Foster
PURPOSE: To identify prognostic factors for poor visual outcome in patients with birdshot retinochoroidopathy. METHODS: A case-control study of 98 patients with birdshot retinochoroidopathy (196 eyes) was evaluated with a follow-up period of at least 12 months. After exclusion of glaucoma, optic atrophy, and macular scar, the remaining eligible patients were categorized into two groups: poor visual outcomes and good visual outcomes. Poor visual outcome was defined as less than -6 mean deviation score on Swedish interactive threshold algorithm (SITA) short-wavelength automated perimetry (SWAP) test and abnormality (amplitude or implicit time) of 30 Hz flicker electroretinogram at 4-year follow-up and at the most recent visit for separate analysis...
April 25, 2016: Retina
Chiea Chuen Khor, Tan Do, Hongyan Jia, Masakazu Nakano, Ronnie George, Khaled Abu-Amero, Roopam Duvesh, Li Jia Chen, Zheng Li, Monisha E Nongpiur, Shamira A Perera, Chunyan Qiao, Hon-Tym Wong, Hiroshi Sakai, Mônica Barbosa de Melo, Mei-Chin Lee, Anita S Chan, Yaakub Azhany, Thi Lam Huong Dao, Yoko Ikeda, Rodolfo A Perez-Grossmann, Tomasz Zarnowski, Alexander C Day, Jost B Jonas, Pancy O S Tam, Tuan Anh Tran, Humaira Ayub, Farah Akhtar, Shazia Micheal, Paul T K Chew, Leyla A Aljasim, Tanuj Dada, Tam Thi Luu, Mona S Awadalla, Naris Kitnarong, Boonsong Wanichwecharungruang, Yee Yee Aung, Jelinar Mohamed-Noor, Saravanan Vijayan, Sripriya Sarangapani, Rahat Husain, Aliza Jap, Mani Baskaran, David Goh, Daniel H Su, Huaizhou Wang, Vernon K Yong, Leonard W Yip, Tuyet Bach Trinh, Manchima Makornwattana, Thanh Thu Nguyen, Edgar U Leuenberger, Ki-Ho Park, Widya Artini Wiyogo, Rajesh S Kumar, Celso Tello, Yasuo Kurimoto, Suman S Thapa, Kessara Pathanapitoon, John F Salmon, Yong Ho Sohn, Antonio Fea, Mineo Ozaki, Jimmy S M Lai, Visanee Tantisevi, Chaw Chaw Khaing, Takanori Mizoguchi, Satoko Nakano, Chan-Yun Kim, Guangxian Tang, Sujie Fan, Renyi Wu, Hailin Meng, Thi Thuy Giang Nguyen, Tien Dat Tran, Morio Ueno, Jose Maria Martinez, Norlina Ramli, Yin Mon Aung, Rigo Daniel Reyes, Stephen A Vernon, Seng Kheong Fang, Zhicheng Xie, Xiao Yin Chen, Jia Nee Foo, Kar Seng Sim, Tina T Wong, Desmond T Quek, Rengaraj Venkatesh, Srinivasan Kavitha, Subbiah R Krishnadas, Nagaswamy Soumittra, Balekudaru Shantha, Boon-Ang Lim, Jeanne Ogle, José P C de Vasconcellos, Vital P Costa, Ricardo Y Abe, Bruno B de Souza, Chelvin C Sng, Maria C Aquino, Ewa Kosior-Jarecka, Guillermo Barreto Fong, Vania Castro Tamanaja, Ricardo Fujita, Yuzhen Jiang, Naushin Waseem, Sancy Low, Huan Nguyen Pham, Sami Al-Shahwan, E Randy Craven, Muhammad Imran Khan, Rrima Dada, Kuldeep Mohanty, Muneeb A Faiq, Alex W Hewitt, Kathryn P Burdon, Eng Hui Gan, Anuwat Prutthipongsit, Thipnapa Patthanathamrongkasem, Mary Ann T Catacutan, Irene R Felarca, Chona S Liao, Emma Rusmayani, Vira Wardhana Istiantoro, Giulia Consolandi, Giulia Pignata, Carlo Lavia, Prin Rojanapongpun, Lerprat Mangkornkanokpong, Sunee Chansangpetch, Jonathan C H Chan, Bonnie N K Choy, Jennifer W H Shum, Hlaing May Than, Khin Thida Oo, Aye Thi Han, Victor H Yong, Xiao-Yu Ng, Shuang Ru Goh, Yaan Fun Chong, Martin L Hibberd, Mark Seielstad, Eileen Png, Sarah J Dunstan, Nguyen Van Vinh Chau, Jinxin Bei, Yi Xin Zeng, Abhilasha Karkey, Buddha Basnyat, Francesca Pasutto, Daniela Paoli, Paolo Frezzotti, Jie Jin Wang, Paul Mitchell, John H Fingert, R Rand Allingham, Michael A Hauser, Soon Thye Lim, Soo Hong Chew, Richard P Ebstein, Anavaj Sakuntabhai, Kyu Hyung Park, Jeeyun Ahn, Greet Boland, Harm Snippe, Richard Stead, Raquel Quino, Su Nyunt Zaw, Urszula Lukasik, Rohit Shetty, Mimiwati Zahari, Hyoung Won Bae, Nay Lin Oo, Toshiaki Kubota, Anita Manassakorn, Wing Lau Ho, Laura Dallorto, Young Hoon Hwang, Christine A Kiire, Masako Kuroda, Zeiras Eka Djamal, Jovell Ian M Peregrino, Arkasubhra Ghosh, Jin Wook Jeoung, Tung S Hoan, Nuttamon Srisamran, Thayanithi Sandragasu, Saw Htoo Set, Vi Huyen Doan, Shomi S Bhattacharya, Ching-Lin Ho, Donald T Tan, Ramanjit Sihota, Seng-Chee Loon, Kazuhiko Mori, Shigeru Kinoshita, Anneke I den Hollander, Raheel Qamar, Ya-Xing Wang, Yik Y Teo, E-Shyong Tai, Curt Hartleben-Matkin, David Lozano-Giral, Seang Mei Saw, Ching-Yu Cheng, Juan C Zenteno, Chi Pui Pang, Huong T T Bui, Owen Hee, Jamie E Craig, Deepak P Edward, Michiko Yonahara, Jamil Miguel Neto, Maria L Guevara-Fujita, Liang Xu, Robert Ritch, Ahmad Tajudin Liza-Sharmini, Tien Y Wong, Saleh Al-Obeidan, Nhu Hon Do, Periasamy Sundaresan, Clement C Tham, Paul J Foster, Lingam Vijaya, Kei Tashiro, Eranga N Vithana, Ningli Wang, Tin Aung
Primary angle closure glaucoma (PACG) is a major cause of blindness worldwide. We conducted a genome-wide association study (GWAS) followed by replication in a combined total of 10,503 PACG cases and 29,567 controls drawn from 24 countries across Asia, Australia, Europe, North America, and South America. We observed significant evidence of disease association at five new genetic loci upon meta-analysis of all patient collections. These loci are at EPDR1 rs3816415 (odds ratio (OR) = 1.24, P = 5.94 × 10(-15)), CHAT rs1258267 (OR = 1...
May 2016: Nature Genetics
Charles D Scales, Tannaz Moin, Arlene Fink, Sandra H Berry, Nasim Afsar-Manesh, Carol M Mangione, B Price Kerfoot
OBJECTIVE: Several barriers challenge resident engagement in learning quality improvement (QI). We investigated whether the incorporation of team-based game mechanics into an evidence-based online learning platform could increase resident participation in a QI curriculum. DESIGN: Randomized, controlled trial. SETTING: Tertiary-care medical center residency training programs. PARTICIPANTS: Resident physicians (n = 422) from nine training programs (anesthesia, emergency medicine, family medicine, internal medicine, ophthalmology, orthopedics, pediatrics, psychiatry and general surgery) randomly allocated to a team competition environment (n = 200) or the control group (n = 222)...
April 2016: International Journal for Quality in Health Care
Brian C Toy, David J Myung, Lingmin He, Carolyn K Pan, Robert T Chang, Alison Polkinhorne, Douglas Merrell, Doug Foster, Mark S Blumenkranz
PURPOSE: To compare clinical assessment of diabetic eye disease by standard dilated examination with data gathered using a smartphone-based store-and-forward teleophthalmology platform. METHODS: 100 eyes of 50 adult patients with diabetes from a health care safety-net ophthalmology clinic. All patients underwent comprehensive ophthalmic examination. Concurrently, a smartphone was used to estimate near visual acuity and capture anterior and dilated posterior segment photographs, which underwent masked, standardized review...
May 2016: Retina
Michelle P Y Chan, Carlota M Grossi, Anthony P Khawaja, Jennifer L Y Yip, Kay-Tee Khaw, Praveen J Patel, Peng T Khaw, James E Morgan, Stephen A Vernon, Paul J Foster
PURPOSE: To describe the associations of physical and demographic factors with Goldmann-correlated intraocular pressure (IOPg) and corneal-compensated intraocular pressure (IOPcc) in a British cohort. DESIGN: Cross-sectional study within the UK Biobank, a large-scale multisite cohort study in the United Kingdom. PARTICIPANTS: We included 110 573 participants from the UK Biobank with intraocular pressure (IOP) measurements available. Their mean age was 57 years (range, 40-69 years); 54% were women, and 90% were white...
April 2016: Ophthalmology
Cécile Delcourt, Jean-François Korobelnik, Gabriëlle H S Buitendijk, Paul J Foster, Christopher J Hammond, Stefano Piermarocchi, Tunde Peto, Nomdo Jansonius, Alireza Mirshahi, Ruth E Hogg, Lionel Bretillon, Fotis Topouzis, Gabor Deak, Jakob Grauslund, Rebecca Broe, Eric H Souied, Catherine Creuzot-Garcher, José Sahel, Vincent Daien, Terho Lehtimäki, Hans-Werner Hense, Elena Prokofyeva, Konrad Oexle, Jugnoo S Rahi, Phillippa M Cumberland, Steffen Schmitz-Valckenberg, Sascha Fauser, Geir Bertelsen, Carel Hoyng, Arthur Bergen, Rufino Silva, Sebastian Wolf, Andrew Lotery, Usha Chakravarthy, Astrid Fletcher, Caroline C W Klaver
The European Eye Epidemiology (E3) consortium is a recently formed consortium of 29 groups from 12 European countries. It already comprises 21 population-based studies and 20 other studies (case-control, cases only, randomized trials), providing ophthalmological data on approximately 170,000 European participants. The aim of the consortium is to promote and sustain collaboration and sharing of data and knowledge in the field of ophthalmic epidemiology in Europe, with particular focus on the harmonization of methods for future research, estimation and projection of frequency and impact of visual outcomes in European populations (including temporal trends and European subregions), identification of risk factors and pathways for eye diseases (lifestyle, vascular and metabolic factors, genetics, epigenetics and biomarkers) and development and validation of prediction models for eye diseases...
February 2016: European Journal of Epidemiology
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