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https://www.readbyqxmd.com/read/29135604/chemical-burns-of-the-eye-the-role-of-retinal-injury-and-new-therapeutic-possibilities
#1
Claes H Dohlman, Fabiano Cade, Caio V Regatieri, Chengxin Zhou, Fengyang Lei, Alja Crnej, Mona Harissi-Dagher, Marie-Claude Robert, George N Papaliodis, Dongfeng Chen, James V Aquavella, Esen K Akpek, Anthony J Aldave, Kimberly C Sippel, Donald J DʼAmico, Jan G Dohlman, Per Fagerholm, Liqiang Wang, Lucy Q Shen, Miguel González-Andrades, James Chodosh, Kenneth R Kenyon, C Stephen Foster, Roberto Pineda, Samir Melki, Kathryn A Colby, Joseph B Ciolino, Demetrios G Vavvas, Shigeru Kinoshita, Reza Dana, Eleftherios I Paschalis
PURPOSE: To propose a new treatment paradigm for chemical burns to the eye - in the acute and chronic phases. METHODS: Recent laboratory and clinical data on the biology and treatment of chemical burns are analyzed. RESULTS: Corneal blindness from chemical burns can now be successfully treated with a keratoprosthesis, on immediate and intermediate bases. Long term outcomes, however, are hampered by early retinal damage causing glaucoma. New data suggest that rapid diffusion of inflammatory cytokines posteriorly (TNF-α, etc) can severely damage the ganglion cells...
November 9, 2017: Cornea
https://www.readbyqxmd.com/read/28903935/glaucoma-and-intraocular-pressure-in-epic-norfolk-eye-study-cross-sectional-study
#2
Michelle P Y Chan, David C Broadway, Anthony P Khawaja, Jennifer L Y Yip, David F Garway-Heath, Jennifer M Burr, Robert Luben, Shabina Hayat, Nichola Dalzell, Kay-Tee Khaw, Paul J Foster
Objectives To report the distribution of intraocular pressure (IOP) by age and sex and the prevalence of glaucoma.Design Community based cross sectional observational study.Setting EPIC-Norfolk cohort in Norwich and the surrounding rural and urban areas.Participants 8623 participants aged 48-92 recruited from the community who underwent ocular examination to identify glaucoma.Main outcome measures Prevalence and characteristics of glaucoma, distribution of IOP, and the sensitivity and specificity of IOP for case finding for glaucoma...
September 13, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28821554/developing-standards-for-the-development-of-glaucoma-virtual-clinics-using-a-modified-delphi-approach
#3
Aachal Kotecha, Simon Longstaff, Augusto Azuara-Blanco, James F Kirwan, James Edwards Morgan, Anne Fiona Spencer, Paul J Foster
PURPOSE: To obtain consensus opinion for the development of a standards framework for the development and implementation of virtual clinics for glaucoma monitoring in the UK using a modified Delphi methodology. METHODS: A modified Delphi technique was used that involved sampling members of the UK Glaucoma and Eire Society (UKEGS). The first round scored the strength of agreement to a series of standards statements using a 9-point Likert scale. The revised standards were subjected to a second round of scoring and free-text comment...
August 18, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28794074/the-incidence-of-acute-angle-closure-in-scotland-a-prospective-surveillance-study
#4
Paul Y Chua, Alexander C Day, Ken L Lai, Nikki Hall, Lai L Tan, Kamran Khan, Lik Thai Lim, Barny Foot, Paul J Foster, Augusto Azuara-Blanco
PURPOSE: To estimate the incidence, and describe the clinical features and short-term clinical outcomes of acute angle closure (AAC). METHODS: Patients with newly diagnosed AAC were identified prospectively over a 12-month period (November 2011 to October 2012) by active surveillance through the Scottish Ophthalmic Surveillance Unit reporting system. Data were collected at case identification and at 6 months follow-up. RESULTS: There were 114 cases (108 patients) reported, giving an annual incidence of 2...
August 9, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28505676/-new-therapeutic-approaches-in-inflammatory-diseases-of-the-eye-targeting-lymphangiogenesis-and-cellular-immunity-research-unit-for-2240-presents-itself
#5
Claus Cursiefen, Felix Bock, Thomas Clahsen, Birgit Regenfuss, Andre Reis, Philipp Steven, Ludwig M Heindl, Jacobus J Bosch, Deniz Hos, Sabine Eming, Rafael Grajewski, Arnd Heiligenhaus, Sascha Fauser, Jennifer Austin, Thomas Langmann
Background Ophthalmology, principally, is a very successful subdiscipline in medicine. Nonetheless, there are still unmet medical needs which necessitate translational research. Methods The funding instrument of a Research Unit (RU) of the German Research Foundation (DFG) is presented as exemplified by the RU 2240 at the Department of Ophthalmology at the University of Cologne. Results The Research Unit integrates different research groups working on pathologic ocular inflammation, macrophages/microglia and (lymph)angiogenesis to collaborate in a synergistic way...
May 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28493391/haplotype-reference-consortium-panel-practical-implications-of-imputations-with-large-reference-panels
#6
Adriana I Iglesias, Sven J van der Lee, Pieter W M Bonnemaijer, René Höhn, Abhishek Nag, Puya Gharahkhani, Anthony P Khawaja, Linda Broer, Paul J Foster, Christopher J Hammond, Pirro G Hysi, Elisabeth M van Leeuwen, Stuart MacGregor, David A Mackey, Johanna Mazur, Stefan Nickels, André G Uitterlinden, Caroline C W Klaver, Najaf Amin, Cornelia M van Duijn
Recently, the Haplotype Reference Consortium (HRC) released a large imputation panel that allows more accurate imputation of genetic variants. In this study, we compared a set of directly assayed common and rare variants from an exome array to imputed genotypes, that is, 1000 genomes project (1000GP) and HRC. We showed that imputation using the HRC panel improved the concordance between assayed and imputed genotypes at common, and especially, low-frequency variants. Furthermore, we performed a genome-wide association meta-analysis of vertical cup-disc ratio, a highly heritable endophenotype of glaucoma, in four cohorts using 1000GP and HRC imputations...
August 2017: Human Mutation
https://www.readbyqxmd.com/read/28211881/a-technician-delivered-virtual-clinic-for-triaging-low-risk-glaucoma-referrals
#7
A Kotecha, J Brookes, P J Foster
PurposeThe purpose of this study is to describe the outcomes of a technician-delivered glaucoma referral triaging service with 'virtual review' of resultant data by a consultant ophthalmologist.Patients and methodsThe Glaucoma Screening Clinic reviewed new optometrist or GP-initiated glaucoma suspect referrals into a specialist ophthalmic hospital. Patients underwent testing by three ophthalmic technicians in a dedicated clinical facility. Data were reviewed at a different time and date by a consultant glaucoma ophthalmologist...
June 2017: Eye
https://www.readbyqxmd.com/read/28073927/new-insights-into-the-genetics-of-primary-open-angle-glaucoma-based-on-meta-analyses-of-intraocular-pressure-and-optic-disc-characteristics
#8
Henriët Springelkamp, Adriana I Iglesias, Aniket Mishra, René Höhn, Robert Wojciechowski, Anthony P Khawaja, Abhishek Nag, Ya Xing Wang, Jie Jin Wang, Gabriel Cuellar-Partida, Jane Gibson, Jessica N Cooke Bailey, Eranga N Vithana, Puya Gharahkhani, Thibaud Boutin, Wishal D Ramdas, Tanja Zeller, Robert N Luben, Ekaterina Yonova-Doing, Ananth C Viswanathan, Seyhan Yazar, Angela J Cree, Jonathan L Haines, Jia Yu Koh, Emmanuelle Souzeau, James F Wilson, Najaf Amin, Christian Müller, Cristina Venturini, Lisa S Kearns, Jae Hee Kang, Yih Chung Tham, Tiger Zhou, Elisabeth M van Leeuwen, Stefan Nickels, Paul Sanfilippo, Jiemin Liao, Herma van der Linde, Wanting Zhao, Leonieke M E van Koolwijk, Li Zheng, Fernando Rivadeneira, Mani Baskaran, Sven J van der Lee, Shamira Perera, Paulus T V M de Jong, Ben A Oostra, André G Uitterlinden, Qiao Fan, Albert Hofman, E-Shyong Tai, Johannes R Vingerling, Xueling Sim, Roger C W Wolfs, Yik Ying Teo, Hans G Lemij, Chiea Chuen Khor, Rob Willemsen, Karl J Lackner, Tin Aung, Nomdo M Jansonius, Grant Montgomery, Philipp S Wild, Terri L Young, Kathryn P Burdon, Pirro G Hysi, Louis R Pasquale, Tien Yin Wong, Caroline C W Klaver, Alex W Hewitt, Jost B Jonas, Paul Mitchell, Andrew J Lotery, Paul J Foster, Veronique Vitart, Norbert Pfeiffer, Jamie E Craig, David A Mackey, Christopher J Hammond, Janey L Wiggs, Ching-Yu Cheng, Cornelia M van Duijn, Stuart MacGregor
Primary open-angle glaucoma (POAG), the most common optic neuropathy, is a heritable disease. Siblings of POAG cases have a ten-fold increased risk of developing the disease. Intraocular pressure (IOP) and optic nerve head characteristics are used clinically to predict POAG risk. We conducted a genome-wide association meta-analysis of IOP and optic disc parameters and validated our findings in multiple sets of POAG cases and controls. Using imputation to the 1000 genomes (1000G) reference set, we identified 9 new genomic regions associated with vertical cup-disc ratio (VCDR) and 1 new region associated with IOP...
January 15, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/27729310/virtual-clinics-in-glaucoma-care-face-to-face-versus-remote-decision-making
#9
Jonathan Clarke, Renata Puertas, Aachal Kotecha, Paul J Foster, Keith Barton
BACKGROUND/AIMS: To examine the agreement in clinical decisions of glaucoma status made in a virtual glaucoma clinic with those made during a face-to-face consultation. METHODS: A trained nurse and technicians entered data prospectively for 204 patients into a proforma. A subsequent face-to-face clinical assessment was completed by either a glaucoma consultant or fellow. Proformas were reviewed remotely by one of two additional glaucoma consultants, and 12 months later, by the clinicians who had undertaken the original clinical examination...
July 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27720551/associations-with-retinal-pigment-epithelium-thickness-measures-in-a-large-cohort-results-from-the-uk-biobank
#10
MULTICENTER STUDY
Fang Ko, Paul J Foster, Nicholas G Strouthidis, Yusrah Shweikh, Qi Yang, Charles A Reisman, Zaynah A Muthy, Usha Chakravarthy, Andrew J Lotery, Pearse A Keane, Adnan Tufail, Carlota M Grossi, Praveen J Patel
PURPOSE: To describe associations of ocular and systemic factors with retinal pigment epithelium (RPE)-Bruch's membrane (BM) complex thickness as measured by spectral-domain (SD) optical coherence tomography (OCT). DESIGN: Multisite community-based study. This research has been conducted using the UK Biobank Resource. PARTICIPANTS: Sixty-seven thousand three hundred eighteen people 40 to 69 years old received questionnaires, physical examination, and eye examination, including macular SD OCT...
January 2017: Ophthalmology
https://www.readbyqxmd.com/read/27707497/effectiveness-of-early-lens-extraction-for-the-treatment-of-primary-angle-closure-glaucoma-eagle-a-randomised-controlled-trial
#11
COMMENT
Augusto Azuara-Blanco, Jennifer Burr, Craig Ramsay, David Cooper, Paul J Foster, David S Friedman, Graham Scotland, Mehdi Javanbakht, Claire Cochrane, John Norrie
BACKGROUND: Primary angle-closure glaucoma is a leading cause of irreversible blindness worldwide. In early-stage disease, intraocular pressure is raised without visual loss. Because the crystalline lens has a major mechanistic role, lens extraction might be a useful initial treatment. METHODS: From Jan 8, 2009, to Dec 28, 2011, we enrolled patients from 30 hospital eye services in five countries. Randomisation was done by a web-based application. Patients were assigned to undergo clear-lens extraction or receive standard care with laser peripheral iridotomy and topical medical treatment...
October 1, 2016: Lancet
https://www.readbyqxmd.com/read/27668130/the-accuracy-and-reliability-of-crowdsource-annotations-of-digital-retinal-images
#12
Danny Mitry, Kris Zutis, Baljean Dhillon, Tunde Peto, Shabina Hayat, Kay-Tee Khaw, James E Morgan, Wendy Moncur, Emanuele Trucco, Paul J Foster
PURPOSE: Crowdsourcing is based on outsourcing computationally intensive tasks to numerous individuals in the online community who have no formal training. Our aim was to develop a novel online tool designed to facilitate large-scale annotation of digital retinal images, and to assess the accuracy of crowdsource grading using this tool, comparing it to expert classification. METHODS: We used 100 retinal fundus photograph images with predetermined disease criteria selected by two experts from a large cohort study...
September 2016: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/27613171/associations-with-intraocular-pressure-across-europe-the-european-eye-epidemiology-e-3-consortium
#13
Anthony P Khawaja, Henriët Springelkamp, Catherine Creuzot-Garcher, Cécile Delcourt, Albert Hofman, René Höhn, Adriana I Iglesias, Roger C W Wolfs, Jean-François Korobelnik, Rufino Silva, Fotis Topouzis, Katie M Williams, Alain M Bron, Gabriëlle H S Buitendijk, Maria da Luz Cachulo, Audrey Cougnard-Grégoire, Jean-François Dartigues, Christopher J Hammond, Norbert Pfeiffer, Angeliki Salonikiou, Cornelia M van Duijn, Johannes R Vingerling, Robert N Luben, Alireza Mirshahi, Julia Lamparter, Caroline C W Klaver, Nomdo M Jansonius, Paul J Foster
Raised intraocular pressure (IOP) is the most important risk factor for developing glaucoma, the second commonest cause of blindness globally. Understanding associations with IOP and variations in IOP between countries may teach us about mechanisms underlying glaucoma. We examined cross-sectional associations with IOP in 43,500 European adults from 12 cohort studies belonging to the European Eye Epidemiology (E(3)) consortium. Each study conducted multivariable linear regression with IOP as the outcome variable and results were pooled using random effects meta-analysis...
November 2016: European Journal of Epidemiology
https://www.readbyqxmd.com/read/27594199/selective-laser-trabeculoplasty-in-controlled-uveitis-with-steroid-induced-glaucoma
#14
Arash Maleki, Robert T Swan, Andres F Lasave, Lina Ma, C Stephen Foster
No abstract text is available yet for this article.
September 1, 2016: Ophthalmology
https://www.readbyqxmd.com/read/27563580/finding-self-directed-learning-readiness-and-fostering-self-directed-learning-through-weekly-assessment-of-self-directed-learning-topics-during-undergraduate-clinical-training-in-ophthalmology
#15
Soumendra Sahoo
BACKGROUND: To know the individual's current level of readiness and to manage self-directed learning (SDL) not only help learners but also the instructors. The objectives of this study were to find SDL readiness among 4(th) year medical student and to analyze the effect of weekly assessment of SDL topics. METHODOLOGY: This was a cross-sectional study to analyze the effect of weekly assessment of SDL topics in fostering SDL. The 51 4(th) year students during a clinical posting in ophthalmology participated for this study...
July 2016: International Journal of Applied and Basic Medical Research
https://www.readbyqxmd.com/read/27551956/topical-beta-blockers-and-cardiovascular-mortality-systematic-review-and-meta-analysis-with-data-from-the-epic-norfolk-cohort-study
#16
REVIEW
Claude Pinnock, Jennifer L Y Yip, Anthony P Khawaja, Robert Luben, Shabina Hayat, David C Broadway, Paul J Foster, Kay-Tee Khaw, Nick Wareham
PURPOSE: To determine if topical beta-blocker use is associated with increased cardiovascular mortality, particularly among people with self-reported glaucoma. METHODS: All participants who participated in the first health check (N = 25,639) of the European Prospective Investigation into Cancer (EPIC) Norfolk cohort (1993-2013) were included in this prospective cohort study, with a median follow-up of 17.0 years. We determined use of topical beta-blockers at baseline through a self-reported questionnaire and prescription check at the first clinical visit...
October 2016: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/27550003/the-history-role-and-value-of-public-directors-on-certifying-boards-the-american-board-of-ophthalmology-experience
#17
Suzanne T Anderson, Lois M Nora, Christine W McEntee, Matthew E Fitzgerald, Samantha Guastella Nugent
The mission of the American Board of Ophthalmology (ABO) is to serve the public by improving the quality of ophthalmic practice through a continuing certification process that fosters excellence and encourages continual learning. Since 2001, achieving this mission has been enhanced by including public directors in the ABO governance. We review the evolution of including nonprofessional members on the governing boards of professional regulatory and self-regulatory organizations generally, provide history about the incorporation of non-professional public directors into the governance structure of the American Board of Medical Specialties and the ABO, and offer insights about the perceived impact of public directors on the ABO...
September 2016: Ophthalmology
https://www.readbyqxmd.com/read/27503126/rehabilitation-of-atrophic-anophthalmic-cavity-with-orthostatic-ocular-prosthesis-a-clinical-report
#18
C F Amaral, J M Cordeiro, T C S Emídio, A G C Presotto, C M R Barbosa
The absence of the eyeball can generate psychosocial and facial harmony changes, such as atrophy of the muscles around it. In these cases, the use of an orthostatic prosthesis with expanding function fosters distension of the tissues for subsequent rehabilitation. This technique consists of making individual ocular prostheses with gradual enlargement of size. The aim of this following clinical report was to describe the technique used in the standing prosthetic rehabilitation of a patient, 73 years old, who underwent enucleation of the right eye as a result of glaucoma...
October 2016: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/27461280/restoration-of-visual-performance-by-d-serine-in-models-of-inner-and-outer-retinal-dysfunction-assessed-using-sweep-vep-measurements-in-the-conscious-rat-and-rabbit
#19
Ursula Staubli, Natalie Rangel-Diaz, Miguel Alcantara, Yong-Xin Li, Jia-Ying Yang, Kai-Ming Zhang, Alan C Foster
The NMDA subtype of glutamate receptor and its co-agonist d-serine play a key role in synaptic function in the central nervous system (CNS), including visual cortex and retina. In retinal diseases such as glaucoma and macular degeneration, a loss of vision arises from malfunction of retinal cells, resulting in a glutamate hypofunctional state along the visual pathway in the affected parts of the visual field. An effective strategy to remedy this loss of function might be to increase extracellular levels of d-serine and thereby boost synaptic NMDA receptor-mediated visual transmission and/or plasticity to compensate for the impairment...
October 2016: Vision Research
https://www.readbyqxmd.com/read/27230295/the-ex-press-glaucoma-filtration-device-implantation-in-uveitic-glaucoma
#20
Swetha Dhanireddy, Ninani C Kombo, Abhishek R Payal, Clovis Arcoverde Freitas-Neto, Janine Preble, C Stephen Foster
PURPOSE: To evaluate the outcomes of the Ex-PRESS Filtration Device in patients with uveitic glaucoma. METHODS: We reviewed 23 eyes, comparing control simple glaucoma patients (n = 11) to uveitic glaucoma patients (n = 12). Intraocular pressure (IOP) and glaucoma medications at the preoperative examination were compared with those at the 6-month and 10-14-month postoperative examination. Surgical success was defined as ≥25% decrease in intraocular pressure without hypotony, and/or decrease in glaucoma medications at 6 months follow-up...
May 26, 2016: Ocular Immunology and Inflammation
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