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https://www.readbyqxmd.com/read/27820876/discriminant-function-of-optical-coherence-tomography-angiography-to-determine-disease-severity-in-glaucoma
#1
Rajesh S Kumar, Neha Anegondi, Rachana S Chandapura, Suria Sudhakaran, Sujatha V Kadambi, Harsha L Rao, Tin Aung, Abhijit Sinha Roy
Purpose: To determine the discriminant function of optical coherence tomography angiography (OCTA) by disease severity in glaucoma. Methods: In this prospective, observational cross-sectional study, all subjects underwent visual fields, retinal nerve fiber layer (RNFL) measurements, and OCTA imaging. Local fractal analysis was applied to OCTA images (radial peripapillary capillaries [RPC] layer). Vessel density en face and inside the disc and spacing between large and small vessels were quantified...
November 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27789225/progress-in-anterior-chamber-angle-imaging-for-glaucoma-risk-prediction-a-review-on-clinical-equipment-practice-and-research
#2
REVIEW
Shinoj V K, Xun Jie Jeesmond Hong, Murukeshan V M, Baskaran M, Aung Tin
The visualization capabilities of various ocular imaging instruments can generally be categorized into photographic (e.g. gonioscopy, Pentacam, RetCam) and optical tomographic (e.g. optical coherence tomography (OCT), photoacoustic (PA) imaging, ultrasound biomicriscopy (UBM)) methods. These imaging instruments allow vision researchers and clinicians to visualize the iridocorneal angle, and are essential in the diagnosis and management of glaucoma. Each of these imaging modalities has particular benefits and associated drawbacks in obtaining repeatable and reliable measurement in the evaluation of the angle...
October 24, 2016: Medical Engineering & Physics
https://www.readbyqxmd.com/read/27777505/plasma-endothelin-1-and-single-nucleotide-polymorphisms-of-endothelin-1-and-endothelin-type-a-receptor-genes-as-risk-factors-for-normal-tension-glaucoma
#3
Ewa Kosior-Jarecka, Dominika Wróbel-Dudzińska, Urszula Łukasik, Tin Aung, Chiea Chuen Khor, Janusz Kocki, Tomasz Żarnowski
PURPOSE: The purpose of this study was to determine whether four single nucleotide polymorphisms (SNPs) of endothelin and endothelin receptor type A genes can constitute a risk factor for normal tension glaucoma (NTG) and high tension glaucoma (HTG). METHODS: The study included 160 patients with NTG, 124 patients with HTG, and 165 healthy controls. To analyze the frequency of polymorphic variants of the endothelin EDN gene (K198N) and the endothelin receptor type A gene EDN RA (C1222T, C70G, G231A), DNA was isolated from peripheral blood, and SNP genotyping was performed using the real-time PCR (RT-PCR) method...
2016: Molecular Vision
https://www.readbyqxmd.com/read/27726963/changes-in-anterior-segment-morphology-and-predictors-of-angle-widening-after-laser-iridotomy-in-south-indian-eyes
#4
Nazlee Zebardast, Srinivasan Kavitha, Palaniswamy Krishnamurthy, David S Friedman, Monisha E Nongpiur, Tin Aung, Harry A Quigley, Pradeep Y Ramulu, Rengaraj Venkatesh
PURPOSE: To compare anterior segment optical coherence tomography (ASOCT) angle morphology before and after laser peripheral iridotomy (LPI) in a cohort of South Indian subjects with primary angle-closure suspect (PACS) or primary angle-closure/primary angle-closure glaucoma (PAC/PACG) and to examine baseline parameters associated with angle widening. DESIGN: Prospective observational study. PARTICIPANTS: A total of 244 subjects aged ≥30 years with PACS or PAC/PACG in at least 1 eye...
October 7, 2016: Ophthalmology
https://www.readbyqxmd.com/read/27488067/glaucoma-genetics-recent-advances-and-future-directions
#5
Tin Aung, Chiea Chuen Khor
Once considered primarily a disease of aging caused by unknown environmental influences, the notion that heritable factors could significantly contribute to the pathogenesis of sporadic glaucoma has rapidly gained traction. In part, this is due to the rapid and definitive identification of genes with strong effects on familial, earlier onset forms of glaucoma. Although the endpoint of glaucoma is irreversible optic nerve damage accompanied by blindness, the initial inciting trigger could differ. To this end, well-powered genome-wide association studies have each been conducted for primary open-angle glaucoma, primary angle-closure glaucoma, along with exfoliation syndrome and glaucoma...
July 2016: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/27486303/inter-eye-comparison-of-retinal-oximetry-and-vessel-caliber-between-eyes-with-asymmetrical-glaucoma-severity-in-different-glaucoma-subtypes
#6
Clarissa Shu Ming Cheng, Yi Fang Lee, Charles Ong, Zhu Li Yap, Andrew Tsai, Aditi Mohla, Monisha E Nongpiur, Tin Aung, Shamira A Perera
BACKGROUND: To compare retinal vessel oxygenation and vessel caliber in primary angle-closure glaucoma (PACG), primary open-angle glaucoma (POAG), normal-tension glaucoma (NTG), and normal controls, as well as between eyes of asymmetrical glaucoma severity. METHODS: This was a prospective, cross-sectional study. The 159 subjects (PACG, n=39; POAG, n=41; NTG, n=41; normal controls, n=38) underwent retinal oxygen saturation measurements using the Oxymap T1 Retinal Oximeter, optical coherence tomography, and Humphrey visual field testing...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27471000/high-resolution-iridocorneal-angle-imaging-system-by-axicon-lens-assisted-gonioscopy
#7
Sandeep Menon Perinchery, Anant Shinde, Chan Yiu Fu, Xun Jie Jeesmond Hong, Mani Baskaran, Tin Aung, Vadakke Matham Murukeshan
Direct visualization and assessment of the iridocorneal angle (ICA) region with high resolution is important for the clinical evaluation of glaucoma. However, the current clinical imaging systems for ICA do not provide sufficient structural details due to their poor resolution. The key challenges in achieving high quality ICA imaging are its location in the anterior region of the eye and the occurrence of total internal reflection due to refractive index difference between cornea and air. Here, we report an indirect axicon assisted gonioscopy imaging probe with white light illumination...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27423311/pattern-of-visual-field-loss-in-primary-angle-closure-glaucoma-across-different-severity-levels
#8
Eray Atalay, Monisha E Nongpiur, Sae Cheong Yap, Tina T Wong, David Goh, Rahat Husain, Shamira A Perera, Tin Aung
PURPOSE: To investigate the patterns of visual field (VF) defects in primary angle-closure glaucoma (PACG) across different severity levels and to assess hemifield differences within each severity level. DESIGN: Cross-sectional study. PARTICIPANTS: Three hundred four patients diagnosed with PACG were recruited from glaucoma clinics at a Singapore hospital. METHODS: Point-wise total deviation values were recorded from the static automated perimetry (Swedish interactive threshold algorithm standard program 24-2; Humphrey model 750 [Carl Zeiss Meditec, Dublin, CA]) printouts...
September 2016: Ophthalmology
https://www.readbyqxmd.com/read/27421069/inter-relationships-between-retinal-vascular-caliber-retinal-nerve-fiber-layer-thickness-and-glaucoma-a-mediation-analysis-approach
#9
Yih-Chung Tham, Rosalynn Grace Siantar, Carol Yim-Lui Cheung, Shu-Pei Tan, Victor T Koh, Tin Aung, Tien Y Wong, Ching-Yu Cheng
PURPOSE: The purpose of this study was to explore the interrelationships among retinal vascular caliber, retinal nerve fiber layer (RNFL), and glaucoma; in particular, whether the relationship between narrower retinal vascular caliber and glaucoma is mediated by thinning of RNFL. METHODS: A total of 9407 participants, including 253 glaucoma and 195 primary open-angle glaucoma (POAG) cases from the Singapore Epidemiology of Eye Diseases Study were included in this study...
July 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27175058/feasibility-study-of-sustained-release-travoprost-punctum-plug-for-intraocular-pressure-reduction-in-an-asian-population
#10
Shamira A Perera, Daniel Sw Ting, Monisha E Nongpiur, Paul T Chew, Maria Cecilia D Aquino, Chelvin Ca Sng, Sue-Wei Ho, Tin Aung
PURPOSE: To investigate the efficacy and safety of a punctum plug-based sustained drug release system for a prostaglandin analog, travoprost (OTX-TP), for intraocular pressure (IOP) reduction in an Asian population. METHODS: This is an initial feasibility, prospective, single-arm study involving 26 eyes and a bioresorbable punctum plug containing OTX-TP. An OTX-TP was placed in the vertical portion of the superior or inferior canaliculus of patients with primary open-angle glaucoma or ocular hypertension...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27149695/finite-element-analysis-predicts-large-optic-nerve-head-strains-during-horizontal-eye-movements
#11
Xiaofei Wang, Helmut Rumpel, Winston Eng Hoe Lim, Mani Baskaran, Shamira A Perera, Monisha E Nongpiur, Tin Aung, Dan Milea, Michaël J A Girard
PURPOSE: We combined finite element (FE) analysis and dynamic magnetic resonance imaging (MRI) to estimate optic nerve head (ONH) strains during horizontal eye movements, and identified factors influencing such strains. We also compared ONH strains (prelamina, lamina cribrosa, and retrolamina strains) induced by eye movements to those induced by IOP. METHODS: The ocular globes and orbits of a healthy subject were visualized during horizontal eye movements (up to 13°), using dynamic MRI...
May 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27064256/genome-wide-association-study-identifies-five-new-susceptibility-loci-for-primary-angle-closure-glaucoma
#12
Chiea Chuen Khor, Tan Do, Hongyan Jia, Masakazu Nakano, Ronnie George, Khaled Abu-Amero, Roopam Duvesh, Li Jia Chen, Zheng Li, Monisha E Nongpiur, Shamira A Perera, Chunyan Qiao, Hon-Tym Wong, Hiroshi Sakai, Mônica Barbosa de Melo, Mei-Chin Lee, Anita S Chan, Yaakub Azhany, Thi Lam Huong Dao, Yoko Ikeda, Rodolfo A Perez-Grossmann, Tomasz Zarnowski, Alexander C Day, Jost B Jonas, Pancy O S Tam, Tuan Anh Tran, Humaira Ayub, Farah Akhtar, Shazia Micheal, Paul T K Chew, Leyla A Aljasim, Tanuj Dada, Tam Thi Luu, Mona S Awadalla, Naris Kitnarong, Boonsong Wanichwecharungruang, Yee Yee Aung, Jelinar Mohamed-Noor, Saravanan Vijayan, Sripriya Sarangapani, Rahat Husain, Aliza Jap, Mani Baskaran, David Goh, Daniel H Su, Huaizhou Wang, Vernon K Yong, Leonard W Yip, Tuyet Bach Trinh, Manchima Makornwattana, Thanh Thu Nguyen, Edgar U Leuenberger, Ki-Ho Park, Widya Artini Wiyogo, Rajesh S Kumar, Celso Tello, Yasuo Kurimoto, Suman S Thapa, Kessara Pathanapitoon, John F Salmon, Yong Ho Sohn, Antonio Fea, Mineo Ozaki, Jimmy S M Lai, Visanee Tantisevi, Chaw Chaw Khaing, Takanori Mizoguchi, Satoko Nakano, Chan-Yun Kim, Guangxian Tang, Sujie Fan, Renyi Wu, Hailin Meng, Thi Thuy Giang Nguyen, Tien Dat Tran, Morio Ueno, Jose Maria Martinez, Norlina Ramli, Yin Mon Aung, Rigo Daniel Reyes, Stephen A Vernon, Seng Kheong Fang, Zhicheng Xie, Xiao Yin Chen, Jia Nee Foo, Kar Seng Sim, Tina T Wong, Desmond T Quek, Rengaraj Venkatesh, Srinivasan Kavitha, Subbiah R Krishnadas, Nagaswamy Soumittra, Balekudaru Shantha, Boon-Ang Lim, Jeanne Ogle, José P C de Vasconcellos, Vital P Costa, Ricardo Y Abe, Bruno B de Souza, Chelvin C Sng, Maria C Aquino, Ewa Kosior-Jarecka, Guillermo Barreto Fong, Vania Castro Tamanaja, Ricardo Fujita, Yuzhen Jiang, Naushin Waseem, Sancy Low, Huan Nguyen Pham, Sami Al-Shahwan, E Randy Craven, Muhammad Imran Khan, Rrima Dada, Kuldeep Mohanty, Muneeb A Faiq, Alex W Hewitt, Kathryn P Burdon, Eng Hui Gan, Anuwat Prutthipongsit, Thipnapa Patthanathamrongkasem, Mary Ann T Catacutan, Irene R Felarca, Chona S Liao, Emma Rusmayani, Vira Wardhana Istiantoro, Giulia Consolandi, Giulia Pignata, Carlo Lavia, Prin Rojanapongpun, Lerprat Mangkornkanokpong, Sunee Chansangpetch, Jonathan C H Chan, Bonnie N K Choy, Jennifer W H Shum, Hlaing May Than, Khin Thida Oo, Aye Thi Han, Victor H Yong, Xiao-Yu Ng, Shuang Ru Goh, Yaan Fun Chong, Martin L Hibberd, Mark Seielstad, Eileen Png, Sarah J Dunstan, Nguyen Van Vinh Chau, Jinxin Bei, Yi Xin Zeng, Abhilasha Karkey, Buddha Basnyat, Francesca Pasutto, Daniela Paoli, Paolo Frezzotti, Jie Jin Wang, Paul Mitchell, John H Fingert, R Rand Allingham, Michael A Hauser, Soon Thye Lim, Soo Hong Chew, Richard P Ebstein, Anavaj Sakuntabhai, Kyu Hyung Park, Jeeyun Ahn, Greet Boland, Harm Snippe, Richard Stead, Raquel Quino, Su Nyunt Zaw, Urszula Lukasik, Rohit Shetty, Mimiwati Zahari, Hyoung Won Bae, Nay Lin Oo, Toshiaki Kubota, Anita Manassakorn, Wing Lau Ho, Laura Dallorto, Young Hoon Hwang, Christine A Kiire, Masako Kuroda, Zeiras Eka Djamal, Jovell Ian M Peregrino, Arkasubhra Ghosh, Jin Wook Jeoung, Tung S Hoan, Nuttamon Srisamran, Thayanithi Sandragasu, Saw Htoo Set, Vi Huyen Doan, Shomi S Bhattacharya, Ching-Lin Ho, Donald T Tan, Ramanjit Sihota, Seng-Chee Loon, Kazuhiko Mori, Shigeru Kinoshita, Anneke I den Hollander, Raheel Qamar, Ya-Xing Wang, Yik Y Teo, E-Shyong Tai, Curt Hartleben-Matkin, David Lozano-Giral, Seang Mei Saw, Ching-Yu Cheng, Juan C Zenteno, Chi Pui Pang, Huong T T Bui, Owen Hee, Jamie E Craig, Deepak P Edward, Michiko Yonahara, Jamil Miguel Neto, Maria L Guevara-Fujita, Liang Xu, Robert Ritch, Ahmad Tajudin Liza-Sharmini, Tien Y Wong, Saleh Al-Obeidan, Nhu Hon Do, Periasamy Sundaresan, Clement C Tham, Paul J Foster, Lingam Vijaya, Kei Tashiro, Eranga N Vithana, Ningli Wang, Tin Aung
Primary angle closure glaucoma (PACG) is a major cause of blindness worldwide. We conducted a genome-wide association study (GWAS) followed by replication in a combined total of 10,503 PACG cases and 29,567 controls drawn from 24 countries across Asia, Australia, Europe, North America, and South America. We observed significant evidence of disease association at five new genetic loci upon meta-analysis of all patient collections. These loci are at EPDR1 rs3816415 (odds ratio (OR) = 1.24, P = 5.94 × 10(-15)), CHAT rs1258267 (OR = 1...
May 2016: Nature Genetics
https://www.readbyqxmd.com/read/26992836/in%C3%A2-vivo-3-dimensional-strain-mapping-of-the%C3%A2-optic-nerve-head-following-intraocular-pressure-lowering-by-trabeculectomy
#13
Michaël J A Girard, Meghna R Beotra, Khai Sing Chin, Amanjeet Sandhu, Monica Clemo, Eleni Nikita, Deborah S Kamal, Maria Papadopoulos, Jean Martial Mari, Tin Aung, Nicholas G Strouthidis
PURPOSE: To map the 3-dimensional (3D) strain of the optic nerve head (ONH) in vivo after intraocular pressure (IOP) lowering by trabeculectomy (TE) and to establish associations between ONH strain and retinal sensitivity. DESIGN: Observational case series. PARTICIPANTS: Nine patients with primary open-angle glaucoma (POAG) and 3 normal controls. METHODS: The ONHs of 9 subjects with POAG (pre-TE IOP: 25.3±13.9 mmHg; post-TE IOP: 11...
June 2016: Ophthalmology
https://www.readbyqxmd.com/read/26810838/determinants-of-pupil-diameters-and-pupil-dynamics-in-an-adult-chinese-population
#14
Ce Zheng, John Mark S de Leon, Carol Y Cheung, Arun K Narayanaswamy, Sim-Heng Ong, Clement W Tan, Paul T Chew, Shamira A Perera, Tien Y Wong, Tin Aung
BACKGROUND: To investigate the determinants of pupil diameter (PD), amplitude of pupil diameter change (PD-change) and speed of pupil constriction (SPC) using video anterior segment optical coherence tomography (AS-OCT) in a population-based sample of Chinese adults. METHODS: Chinese adults aged 40 to 80 years who were free from glaucoma were consecutively recruited from the population-based Singapore Chinese Eye Study. The SPC was measured by AS-OCT videography...
May 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/26707418/argon-laser-peripheral-iridoplasty-for-primary-angle-closure-glaucoma-a-randomized-controlled-trial
#15
RANDOMIZED CONTROLLED TRIAL
Arun Narayanaswamy, Mani Baskaran, Shamira A Perera, Monisha E Nongpiur, Hla M Htoon, Tin A Tun, Tina T Wong, David Goh, Daniel H Su, Paul T K Chew, Ching-Lin Ho, Tin Aung
PURPOSE: To determine the effectiveness of argon laser peripheral iridoplasty (ALPI) in primary angle closure (PAC) and primary angle-closure glaucoma (PACG). DESIGN: Randomized controlled trial. PARTICIPANTS: Eighty PAC or PACG subjects who underwent laser iridotomy (LI) and had at least 180° of persistent appositional angle closure and intraocular pressure (IOP) of more than 21 mmHg were enrolled. METHODS: Subjects were randomized to receive either 360° ALPI (Visulas 532s; Carl Zeiss Meditec, Jena, Germany) or medical therapy (Travoprost 0...
March 2016: Ophthalmology
https://www.readbyqxmd.com/read/26648686/clinical-effectiveness-of-brinzolamide-1-brimonidine-0-2-fixed-combination-for-primary-open-angle-glaucoma-and-ocular-hypertension
#16
REVIEW
Sourabh Sharma, Sameer Trikha, Shamira A Perera, Tin Aung
The main first-line treatment strategy for glaucoma is to reduce intraocular pressure (IOP) by topical ocular hypotensive medications, but many patients require multiple medications for adequate IOP control. Fixed-combination therapies provide several benefits, including simplified treatment regimens, theoretical improved treatment adherence, elimination of the potential for washout of the first drug by the second, and the reduction in ocular exposure to preservatives. β-Adrenoceptor antagonists (particularly 0...
2015: Clinical Ophthalmology
https://www.readbyqxmd.com/read/26550974/cyp1b1-and-myoc-mutations-in-vietnamese-primary-congenital-glaucoma-patients
#17
Tan Do, William Shei, Pham Thi Minh Chau, Doan Le Trang, Victor H K Yong, Xiao Yu Ng, Yue Ming Chen, Tin Aung, Eranga N Vithana
PURPOSE: Primary congenital glaucoma (PCG, OMIM 231300), the most common glaucoma in infancy, is caused by developmental defects in the anterior chamber angle. The 3 implicated genes are cytochrome P450 family I subfamily B polypeptide 1 (CYP1B1), latent transforming growth factor β-binding protein 2 (LTBP2), and myocilin (MYOC). In this study, we sought to determine CYP1B1 and MYOC sequence variations in a Vietnamese cohort of index cases with PCG and their families. METHODS: Thirty Vietnamese subjects with PCG and 120 normal Vietnamese subjects were recruited...
May 2016: Journal of Glaucoma
https://www.readbyqxmd.com/read/26550964/persistence-of-glaucoma-therapy-and-visual-field-progression
#18
John M S de Leon, Desmond T Quek, Hla M Htoon, Tin A Tun, Shamira A Perera, Ecosse L Lamoureux, Tin Aung
PURPOSE: To determine the association of visual field (VF) progression with medication persistence in a cohort on glaucoma therapy. PATIENTS AND METHODS: Pharmacy records were examined over 3 years for patients started on glaucoma monotherapy. A patient was persistent if a prescription was refilled for the same medication < 90 days after the previous prescription had lapsed; otherwise was nonpersistent. Only patients with > 5 reliable VFs within 1-year pretherapy and 6-year posttherapy were included...
April 2016: Journal of Glaucoma
https://www.readbyqxmd.com/read/26549406/impact-of-visual-impairment-and-eye-diseases-on-mortality-the-singapore-malay-eye-study-simes
#19
Rosalynn Grace Siantar, Ching-Yu Cheng, Chui Ming Gemmy Cheung, Ecosse L Lamoureux, Peng Guan Ong, Khuan Yew Chow, Paul Mitchell, Tin Aung, Tien-Yin Wong, Carol Y Cheung
We investigated the relationship of visual impairment (VI) and age-related eye diseases with mortality in a prospective, population-based cohort study of 3,280 Malay adults aged 40-80 years between 2004-2006. Participants underwent a full ophthalmic examination and standardized lens and fundus photographic grading. Visual acuity was measured using logMAR chart. VI was defined as presenting (PVA) and best-corrected (BCVA) visual acuity worse than 0.30 logMAR in the better-seeing eye. Participants were linked with mortality records until 2012...
2015: Scientific Reports
https://www.readbyqxmd.com/read/26383992/a-genetic-variant-in-tgfbr3-cdc7-is-associated-with-visual-field-progression-in-primary-open-angle-glaucoma-patients-from-singapore
#20
Sameer Trikha, Ehsan Saffari, Monisha Nongpiur, Mani Baskaran, Henrietta Ho, Zheng Li, Peng-Yi Tan, John Allen, Chiea-Chuen Khor, Shamira A Perera, Ching-Yu Cheng, Tin Aung, Eranga Vithana
PURPOSE: To investigate whether known genetic loci for primary open-angle glaucoma (POAG) are associated with visual field (VF) progression in patients from a Singaporean Chinese population. DESIGN: Retrospective study. PARTICIPANTS: Patients with 5 or more reliable VF measurements who were being followed up at a Singapore hospital. METHODS: Visual field progression was identified using Progressor software version 3...
December 2015: Ophthalmology
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