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https://www.readbyqxmd.com/read/28709911/increased-drug-load-and-polymer-compatibility-of-bilayered-orodispersible-films
#1
J Carolina Visser, Oekie A F Weggemans, René J Boosman, Katja U Loos, Henderik W Frijlink, Herman J Woerdenbag
The addition of enalapril maleate to a casting solution for orodispersible films (ODFs) containing hypromellose and carbomer 974P as film forming agents (standard casting solution, SCS) caused a dose dependent reduction of the viscosity. This phenomenon was a serious problem in the preparation of ODFs with an increased enalapril load (>1mg per ODF) when using the solvent casting method. The aim of the present work was twofold. Firstly, the influence of enalapril on the viscosity of SCS was studied in more detail...
July 12, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28708606/effect-of-hydroxypropyl-cellulose-hpc-polyvinylpyrrolidone-pvp-and-polyethylene-glycol-peg-on-nd-tio2-graphene-oxide-nanocomposite-for-removal-of-lead-ii-and-copper-ii-from-aquatic-media
#2
Susan Samadi, Sayed Mohammad Hosain Mirseyfifard, Mina Assari, Marzieh Hassannejad
In order to investigate the effect of hydroxypropyl cellulose (HPC), polyvinylpyrrolidone (PVP) and polyethylene glycol (PEG) on adsorbing capacity of nanosorbent Nd-TiO2/GO, Nd-TiO2/HPC/GO, Nd-TiO2/PVP/GO and Nd-TiO2/PEG/GO nanocomposites were synthesized. Studies by Fourier transform infrared spectroscopy confirmed the expected structure and X-ray diffraction results confirmed the formation of crystalline phase of anatase titania and also graphene oxide (GO). Scanning electron microscopy pictures and energy dispersive X-ray spectroscopy analysis showed the formation of Nd-TiO2 nanoparticles...
July 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28707628/brainframe-a-node-level-heterogeneous-accelerator-platform-for-neuron-simulations
#3
Georgios Smaragdos, Georgios Chatzikonstantis, Rahul Kukreja, Harry Sidiropoulos, Dimitrios Rodopoulos, Ioannis Sourdis, Zaid Al-Ars, Christoforos Kachris, Dimitrios Soudris, Chris de Zeeuw, Christos Strydis
OBJECTIVE: The advent of High-Performance Computing (HPC) in recent years has led to its increasing use in brain study through computational models. The scale and complexity of such models are constantly increasing, leading to challenging computational requirements. Even though modern HPC platforms can often deal with such challenges, the vast diversity of the modeling field does not permit for a homogeneous acceleration platform to effectively address the complete array of modeling requirements...
July 14, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28695931/methods-of-protein-corona-isolation-for-magnetic-nanoparticles
#4
Debora Bonvin, Diego Chiappe, Marc Moniatte, Heinrich Hofmann, Marijana Mionić Ebersold
Nanoparticles (NPs) in contact with a biological environment get covered by proteins and some are loosely bound and some are tightly bound. The latter form a hard protein corona (HPC) which is known to determine their biological behavior. Therefore, in order to study the biological behaviour of NPs one needs to start from the HPC. However, established methods and standards of HPC isolation are still not known. This is especially a challenge in the case of magnetic NPs which form a major branch of nanomedicine...
July 11, 2017: Analyst
https://www.readbyqxmd.com/read/28691143/meningeal-haemangiopericytoma-and-solitary-fibrous-tumour-a-retrospective-bi-centre-study-for-outcome-and-prognostic-factor-assessment
#5
Charles Champeaux, Akbar Ali Khan, Elena Wilson, Lewis Thorne, Laurence Dunn
To describe the outcome of patients diagnosed with central nervous system haemangiopericytoma (HPC) or solitary fibrous tumour (SFT) and identify factors that may influence recurrence and survival. Between January 2000 and September 2016, a retrospective search identified 55 HPCs/SFTs. The patients underwent a total of 101 surgical resections and 56.9% received radiation therapy. Median follow-up was 7.8 years. 28 patients (50.9%) were re-operated for tumour recurrence. At the end of the study, 21 patients (42%) had no residual tumour on the last scan...
July 10, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28691017/reduction-of-the-oxidative-stress-status-using-steviol-glycosides-in-a-fish-model-cyprinus-carpio
#6
Livier Mireya Sánchez-Aceves, Octavio Dublán-García, Leticia-Xochitl López-Martínez, Karen Adriana Novoa-Luna, Hariz Islas-Flores, Marcela Galar-Martínez, Sandra García-Medina, María Dolores Hernández-Navarro, Leobardo Manuel Gómez-Oliván
Steviol glycosides are sweetening compounds from the Stevia rebaudiana Bertoni plant. This product is considered safe for human consumption and was approved as a food additive by the Food and Drugs Administration (FDA) and European Food Safety Authority (EFSA). Its effects on the ecosystem have not been studied in depth; therefore, it is necessary to carry out ecotoxicological studies in organisms such as Cyprinus carpio. The present study aimed to evaluate the antioxidant activity by SGs on diverse tissues in C...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28690777/hemangiopericytoma-of-the-thoracic-spine-a-case-report
#7
Luen Shaun Chew, Xinguang Julian Han, Kheng Kooi Tan, Manish Mahadeorao Bundele
Hemangiopericytoma (HPC) has been described to be aggressive and potentially a malignant tumour. We report a rare case of a 63-year-old Chinese male who presented with primary intradural extramedullary HPC of the thoracic spine. The main presenting complaint was gradual progression of back pain, associated with paraparesis and sensory deficit of lower limbs. He had MRI thoracolumbar with contrast which showed T9 lesion compressing on spinal cord and oedema, he was then operated upon and histopathology report confirmed a thoracic spine HPC...
July 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/28686806/hippocampal-damage-causes-retrograde-but-not-anterograde-memory-loss-for-context-fear-discrimination-in-rats
#8
Justin Q Lee, Robert J Sutherland, Robert J McDonald
There is a substantial body of evidence that the hippocampus (HPC) plays and essential role in context discrimination in rodents. Studies reporting anterograde amnesia (AA) used repeated, alternating, distributed conditioning and extinction sessions to measure context fear discrimination. In addition, there is uncertainty about the extent of damage to the HPC. Here, we induced conditioned fear prior to discrimination tests and rats sustained extensive, quantified pre- or post-training HPC damage. Unlike previous work, we found that extensive HPC damage spares context discrimination, we observed no AA...
July 7, 2017: Hippocampus
https://www.readbyqxmd.com/read/28686010/monoclinic-zif-8-nanosheets-derived-2d-carbon-nanosheets-as-sulfur-immobilizer-for-high-performance-lithium-sulfur-batteries
#9
Yi Jiang, Haiqiang Liu, Xinghua Tan, Limin Guo, Jiangtao Zhang, Shengnan Liu, Yanjun Guo, Juan Zhang, Hanfu Wang, Weiguo Chu
2D hierarchically porous carbon (2D-HPC) nanosheets with unique advantages are highly desired as host materials for lithium sulfur (Li-S) batteries and other energy storage devices. Herein, we propose a self-template and organic solvent-free approach to synthesize nanosheets of monoclinic ZIF-8 at room temperature from which 2D-HPC nanosheets (ZIF-8 Nanosheets Carbon denoted as ZIF-8-NS-C) are derived to be an efficient sulfur immobilizer for Li-S batteries for the first time. The anisotropic nanosheets are believed to relate to the symmetry of the monoclinic structure...
July 7, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28683425/sublethal-effects-induced-by-captopril-on-cyprinus-carpio-as-determined-by-oxidative-stress-biomarkers
#10
María Julieta Azalea Cortes-Diaz, Juana Rodríguez-Flores, Gregorio Castañeda-Peñalvo, Marcela Galar-Martínez, Hariz Islas-Flores, Octavio Dublán-García, Leobardo Manuel Gómez-Oliván
To our knowledge, this is the first study to evaluate captopril-induced oxidative stress in fish, and specifically in the common carp Cyprinus carpio. At present, very few studies in the international literature evaluate the sublethal effects of captopril on aquatic organisms such as fish, and available ones focus on determination of median lethal concentration in crustaceans and algae. Also, studies evaluating these effects do not make reference to the mechanism of action of this pharmaceutical or its toxicokinetics...
July 3, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28680212/-18-f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-findings-of-pancreatic-hemangiopericytoma
#11
Funda Ustun, Salim Aksoy, Burcu Dirlik Serim, Gülay Durmus Altun
A 42-year-old woman with a large pancreatic tumor had undergone (18)F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) imaging. Moderate metabolic activity was detected on the head of the pancreas. The tumor was resected and it was histopathologically diagnosed as malign pancreatic hemangiopericytoma (HPC). HPC is a rare soft tissue sarcoma. The tumor is considered aggressive with high rates of local recurrence and metastasis regardless the localization. Herein, we present the imaging characteristics of HPC with (18)F-FDG PET/CT...
July 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/28662623/engagement-of-primary-care-physicians-in-home-palliative-care
#12
Shiraz Malik, Russell Goldman, Nanor Kevork, Kirsten Wentlandt, Amna Husain, Nancy Merrow, Lisa W Le, Camilla Zimmermann
PURPOSE: To describe prevalence and characteristics associated with family physician and general practitioner (FP/GP) provision of home palliative care (HPC). METHODS: We surveyed FP/GPs in an urban health region of Ontario, Canada, to determine their current involvement in HPC, the nature of services provided, and perceived barriers and enablers. RESULTS: A total of 1439 surveys were mailed. Of the 302 FP/GP respondents, 295 provided replies regarding engagement in HPC: 101 of 295 (33%) provided HPC, 76 (26%) were engageable with further support, and 118 (40%) were not engageable regardless of support...
January 2017: Journal of Palliative Care
https://www.readbyqxmd.com/read/28661266/argon-and-helium-plasma-coagulation-of-porcine-liver-tissue
#13
Tim R Glowka, Jens Standop, Pascal Paschenda, Michael Czaplik, Jörg C Kalff, René H Tolba
Objective Argon plasma coagulation (APC) and helium plasma coagulation (HPC) are electrosurgical techniques that provide noncontact monopolar electrothermal haemostasis. Although these techniques have been widely used clinically during the last three decades, their in vivo effects on liver tissue remain unclear. Methods We investigated the effects of different power levels (10-100 W) of APC and HPC on liver coagulation in 11 Landrace pigs. Capillary blood flow and capillary blood flow velocity were recorded with a combined laser Doppler flowmeter and spectrophotometer...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28659516/surface-modified-polythiophene-nanocomposite-using-hpc-and-dbsna-for-heavy-metal-ion-removal
#14
Vahideh Arabahmadi, Mohsen Ghorbani
In the present work, surface modified nanocomposite adsorbents polythiophene (PTh)/rice husk ash (RHA) have successfully been synthesized in the presence of hydroxyl propyl cellulose (HPC) and sodium dodecyl benzene sulfonate (DBSNa) as surfactants. The synthesized nanoparticles were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM) and Fourier transform infrared spectroscopy (FTIR), and the synthesized nanocomposite adsorbents were applied as an efficient sorbent for Pb(II) ion removal from contaminated water and the removal efficiency was compared to pure PTh/RHA composite...
June 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28659031/gypenosides-ameliorate-carbon-tetrachloride-induced-liver-fibrosis-by-inhibiting-the-differentiation-of-hepatic-progenitor-cells-into-myofibroblasts
#15
Jiamei Chen, Xuewei Li, Yonghong Hu, Wei Liu, Qun Zhou, Hua Zhang, Yongping Mu, Ping Liu
Gypenosides (GPs), the predominant components of Gynostemma pentaphyllum, exert antifibrotic effects; however, the mechanisms underlying their ability to ameliorate liver fibrosis are unclear. Liver fibrosis was induced in C57BL/6 mice via subcutaneous injection of 10% carbon tetrachloride (CCl[Formula: see text] three times a week for two weeks. Then, CCl4 was administered in conjunction with intragastric GPs for another three weeks. For in vitro analyses, WB-F344, hepatatic progenitor cells (HPCs) were treated with transforming growth factor beta 1 (TGF-β1) with or without GPs for 48[Formula: see text]h...
June 28, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/28652936/divide-and-conquer-dc-blast-fast-and-easy-blast-execution-within-hpc-environments
#16
Won Cheol Yim, John C Cushman
Bioinformatics is currently faced with very large-scale data sets that lead to computational jobs, especially sequence similarity searches, that can take absurdly long times to run. For example, the National Center for Biotechnology Information (NCBI) Basic Local Alignment Search Tool (BLAST and BLAST+) suite, which is by far the most widely used tool for rapid similarity searching among nucleic acid or amino acid sequences, is highly central processing unit (CPU) intensive. While the BLAST suite of programs perform searches very rapidly, they have the potential to be accelerated...
2017: PeerJ
https://www.readbyqxmd.com/read/28651556/clinical-outcomes-of-transoral-videolaryngoscopic-surgery-for-hypopharyngeal-and-supraglottic-cancer
#17
Yorihisa Imanishi, Hiroyuki Ozawa, Koji Sakamoto, Ryoichi Fujii, Seiji Shigetomi, Noboru Habu, Kuninori Otsuka, Yoichiro Sato, Yoshihiro Watanabe, Mariko Sekimizu, Fumihiro Ito, Toshiki Tomita, Kaoru Ogawa
BACKGROUND: Transoral videolaryngoscopic surgery (TOVS) was developed as a new distinct surgical procedure for hypopharyngeal cancer (HPC) and supraglottic cancer (SGC) staged at up to T3. However, long-term treatment outcomes of TOVS remain to be validated. METHODS: Under a straight broad intraluminal view provided by combined use of a distending laryngoscope and a videolaryngoscope, we performed en bloc tumor resection via direct bimanual handling of the ready-made straight-form surgical instruments and devices...
June 26, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28650817/memaxes-visualization-and-analytics-for-characterizing-complex-memory-performance-behaviors
#18
Adolfo Alfredo Gimenez, Todd Gamblin, Ilir Jusufi, Abhinav Bhatele, Martin Schulz, Peer-Timo Bremer, Bernd Hamann
Memory performance is often a major bottleneck for high-performance computing (HPC) applications. Deepening memory hierarchies, complex memory management, and non-uniform access times have made memory performance behavior difficult to characterize, and users require novel, sophisticated tools to analyze and optimize this aspect of their codes. Existing tools target only specific factors of memory performance, such as hardware layout, allocations, or access instructions. However, today's tools do not suffice to characterize the complex relationships between these factors...
June 22, 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/28650454/analysis-of-hematopoietic-recovery-after-autologous-transplantation-as-method-of-quality-control-for-long-term-progenitor-cell-cryopreservation
#19
J Pavlů, H W Auner, R M Szydlo, B Sevillano, R Palani, F O'Boyle, A Chaidos, C Jakob, E Kanfer, D MacDonald, D Milojkovic, A Rahemtulla, A Bradshaw, E Olavarria, J F Apperley, O M Pello
Hematopoietic precursor cells (HPC) are able to restore hematopoiesis after high-dose chemotherapy and their cryopreservation is routinely employed prior to the autologous hematopoietic cell transplantation (AHCT). Although previous studies showed feasibility of long-term HPC storage, concerns remain about possible negative effects on their potency. To study the effects of long-term cryopreservation, we compared time to neutrophil and platelet recovery in 50 patients receiving two AHCT for multiple myeloma at least 2 years apart between 2006 and 2016, using HPC obtained from one mobilization and collection attempt before the first transplant...
June 26, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28650336/design-and-content-determination-of-genhuang-dispersible-tablet-herbal-formulation
#20
Rui-Hua Xin, Ge Liang, Ji-Fang Zheng
The aim of the present study was to optimize the shaping technology of the traditional herbal formula Genhuang dispersible tablets, and also establish a method for content determination. The optimal formulation of Genhuang dispersible tablets was determined based on the results of single factor test and orthogonal design test. The disintegration was used as the main study indicator. The proportion of each adjuvant in the optimal formulation consisted of 40% MCC as bulking agent, 15% PVPP and 7% L-HPC as disintegrant, ethanol as adhesive, CSD as lubricant, preparing the dispersible tablets with wet granulation...
March 2017: Pakistan Journal of Pharmaceutical Sciences
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