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https://www.readbyqxmd.com/read/28319361/block-copolymer-templated-hierarchical-porous-carbon-nanostructures-with-nitrogen-rich-functional-groups-for-molecular-sensing
#1
Ya-Sen Sun, Chien-Fu Lin, Shih-Ting Luo, Ching-Yuan Su
The self-assembly of a block copolymer offers access to micellar nanodomains with tunable dimensions and structural diversity through control of such molecular parameters as the volume fraction and molecular mass. We fabricated hierarchical porous carbon (HPC) nanostructures with bundles of aggregated nanospheres and with nitrogen-rich functional groups through pyrolysis of diblock copolymer micelles in multiple layers. The resultant HPC nanostructures with a considerable specific surface area serve as an excellent substrate for surface-enhanced Raman spectroscopy (SERS), coupled with fluorescence quenching, for molecular sensing of physically adsorbed Rhodamine 6G...
March 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28301051/adverse-events-of-cryopreserved-hematopoietic-stem-cell-infusions-in-adults-a-single-center-observational-study
#2
Zaher K Otrock, Diane S Sempek, Sherry Carey, Brenda J Grossman
BACKGROUND: Autologous hematopoietic stem cell (HSC) transplantation has been used for almost three decades for the management of malignant hematologic diseases and some solid tumors. Dimethyl sulfoxide (DMSO) is used as a cryoprotective agent for hematopoietic progenitor cells (HPCs) collected by apheresis (HPC-A). We evaluated the factors contributing to the occurrence of adverse events (AEs) of cryopreserved HPC-A infusion. STUDY DESIGN AND METHODS: Between January 2009 and June 2014, a total of 1269 (1191 patients) consecutive HPC-A infusions were given to adult patients undergoing autologous HSC transplantation at Barnes-Jewish Hospital...
March 16, 2017: Transfusion
https://www.readbyqxmd.com/read/28295484/who-2016-classification-changes-and-advancements-in-the-diagnosis-of-miscellaneous-primary-cns-tumours
#3
Felix Sahm, David E Reuss, Caterina Giannini
This short review highlights significant changes and recent findings incorporated to varying extent in the WHO 2016 definition of a variety of tumours, including peripheral nerve sheath tumours, meningiomas, mesenchymal non-meningothelial tumours, melanocytic tumours, lymphomas and histiocytic tumours, germ cell tumours and non-neuroendocrine pituitary tumours. Most notable classification changes include: adding "hybrid nerve sheath tumours" to the spectrum of benign nerve sheath tumours; an updated definition of atypical meningioma (WHO grade II), including cases with brain invasion; recognizing dural solitary fibrous tumour (SFT) and haemangiopericytoma (HPC) as a single tumour entity characterized by NAB2 and STAT6 gene fusions for which the term solitary SFT/HPC was chosen; recognizing that pituitary granular cell tumour, spindle cell oncocytoma, and pituicytoma all share nuclear expression of TTF-1, possibly representing a spectrum of a single nosological entity derived from posterior pituitary glial cells...
March 12, 2017: Neuropathology and Applied Neurobiology
https://www.readbyqxmd.com/read/28293427/indicator-bacteria-community-in-seawater-and-coastal-sediment-the-persian-gulf-as-a-case
#4
Vahid Noroozi Karbasdehi, Sina Dobaradaran, Iraj Nabipour, Afshin Ostovar, Hossein Arfaeinia, Amir Vazirizadeh, Roghayeh Mirahmadi, Mozhgan Keshtkar, Fatemeh Faraji Ghasemi, Farzaneh Khalifei
BACKGROUND: The aim of present work was to assess the concentration levels as well as vertical distribution of indicator bacteria including total coliform, fecal coliform, Pseudomonas aeruginosa, and Heterotrophic Plate Count (HPC) in the marine environment (seawater and coastal sediments) and evaluate the correlation between indicator bacteria and some physicochemical parameters of surface sediments as well as seawaters. METHODS: A total number of 48 seawater and sediment samples were taken from 8 stations (each site 6 times with an interval time of 2 weeks) between June and September 2014...
2017: Journal of Environmental Health Science & Engineering
https://www.readbyqxmd.com/read/28285498/profiling-total-viable-bacteria-in-a-hemodialysis-water-treatment-system
#5
Lihua Chen, Xuan Zhu, Menglu Zhang, Yuxin Wang, Tianyu Lv, Shenghua Zhang, Xin Yu
The culture-dependent methods such as heterotrophic plate counting (HPC) are usually applied to evaluate the bacteriological quality of the hemodialysis water. However, these methods cannot detect the uncultured or viable but non-culturable (VBNC) bacteria both of which may be quantitatively predominant throughout the hemodialysis water treatment system. Therefore, PMA-qPCR associated with HPC was used together to profile the distribution of the total viable bacteria in such a system. Moreover, high-throughput sequencing of 16s rRNA gene amplicons was utilized to analyze the microbial community structure and diversity...
March 13, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28279867/hollow-structured-conjugated-porous-polymer-derived-iron-nitrogen-codoped-hierarchical-porous-carbons-as-highly-efficient-electrocatalysts
#6
Wenbei Zhang, Tianlu Cui, Lingyun Yang, Chao Zhang, Ming Cai, Sai Sun, Yefeng Yao, Xiaodong Zhuang, Fan Zhang
Iron and nitrogen (Fe/N) co-doped porous carbons have already shown great potential as electrocatalysts for oxygen reduction reaction in alkaline media. However, it still remains a great challenge to finely integrate a hierarchical porous structure and Fe/N co-doping effect into one material at the same time. In this work, a rational design toward Fe/N-codoped hierarchical porous carbon spheres was developed by the formation of an iron-porphyrin-containing conjugated microporous polymer sphere with hollow structure (HCMP) through a silica sphere template directed condensation of pyrrole and 1,4-phthalaldehyde, then etched with NaOH, and treated with FeCl2...
February 28, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28276321/downregulation-of-calcium-binding-protein-s100a9-inhibits-hypopharyngeal-cancer-cell-proliferation-and-invasion-ability-through-inactivation-of-nf%C3%AE%C2%BAb-signaling
#7
Ping Wu, Huatao Quan, Jing Kang, Jian He, Shi Luo, Chubo Xie, Jing Xu, Yaoyun Tang, Suping Zhao
Hypopharyngeal cancer (HPC) frequently present at an advanced stage, and display early submucosal spread, resulting inpoor prognosis, among the worst of all head and neck subsites. Detection of HPC at an earlier stage would be beneficial to patients. In this study, we used Differential in-gel electrophoresis (DIGE) and two-dimensional polyacrylamide gel electrophoresis (2-DE) proteomics analysis to indentify the potential biomarkers for HPC. Among the differential proteins identified, calcium binding protein S100A9 was overexpressed in HPC tissues compared with normal adjacent tissues, and S100A9 expression in metastatic tissues and advanced tumor tissues was higher than in non-metastatic tissues and early tumor tissues, respectively...
March 8, 2017: Oncology Research
https://www.readbyqxmd.com/read/28276299/immunohistochemical-analysis-of-the-stem-cell-marker-lgr5-in-pediatric-liver-disease
#8
Zahida Khan, Anne Orr, George K Michalopoulos, Sarangarajan Ranganathan
Aims In regenerating liver, hepatic progenitor cells (HPCs) are recruited in response to injury; however, few highly specific human HPC markers exist for the hepatocyte lineage. Leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5), a Wnt-associated stem cell marker, has been extensively studied in intestinal stem cells, but little is known about its expression in human liver. We hypothesized that LGR5+ HPCs are induced in the regenerative response to pediatric liver injury. Methods and results Immunohistochemistry was used to characterize LGR5 expression in pediatric liver explants (n = 36)...
January 2017: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/28274190/evaluating-the-biosafety-of-conventional-and-o3-bac-process-and-its-relationship-with-nom-characteristics
#9
Xiaobin Liao, Rusen Zou, Chao Chen, Baoling Yuan, Zhenming Zhou, Xiaojian Zhang
It is the priority to guarantee biosafety for drinking water treatment. The objective of this study was to evaluate the impact of widely applied conventional and ozone-biological activated carbon (O3-BAC) advanced treatment technology on biosafety of drinking water. The items, including assimilable organic carbon (AOC), biodegradable dissolved organic carbon (BDOC), heterotrophic plate counts (HPCs) and the microorganism community structures, were used to evaluate the biosafety. Moreover, their relationships with molecular weights (MWs) and fluorescence intensity of dissolved organic matter were investigated...
March 8, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28262530/comparison-of-heater-probe-coagulation-and-argon-plasma-coagulation-in-the-management-of-mallory-weiss-tears-and-high-risk-ulcer-bleeding
#10
Mete Akin, Erhan Alkan, Yasar Tuna, Tolga Yalcinkaya, Bulent Yildirim
BACKGROUND AND STUDY AIMS: Upper gastrointestinal (GI) bleeding is a common medical emergency. Endoscopic treatments often lead to better therapeutic outcomes than conventional conservative treatments. This study aimed to investigate and compare the use of heater probe coagulation (HPC) and argon plasma coagulation (APC) together with epinephrine injection for the treatment of Mallory-Weiss tears and high-risk ulcer bleeding. PATIENTS AND METHODS: A total of 97 patients (54 in the HPC group and 43 in the APC group) who were diagnosed with upper GI bleeding secondary to a Mallory-Weiss tear or high-risk gastric or duodenal ulcers were included in the study...
March 2, 2017: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
https://www.readbyqxmd.com/read/28259094/prediction-of-the-hydroxypropyl-cellulose-poly-vinyl-alcohol-ratio-in-aqueous-solution-containing-papaverine-hydrochloride-in-terms-of-drug-loaded-electrospun-fiber-formation
#11
Adrienn Kazsoki, Péter Szabó, Romána Zelkó
Papaverine hydrochloride loaded electrospun fibers were prepared for buccal drug delivery with the aim of improving the oral bioavailability of the crystalline drug, which can be achieved by the increased solubility and by the circumvention of the intensive first pass metabolism. The water soluble hydroxypropyl cellulose (HPC) was chosen as a mucoadhesive polymer. In order to improve the electrospinnability of HPC, the also mucoadhesive poly(vinyl alcohol) (PVA) was used. During the experiments, the total polymer concentration was kept constantly at 15% (w/w), and only the ratio of the two polymers was changed...
February 22, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28257889/chronic-intermittent-ethanol-exposure-leads-to-alterations-in-brain-derived-neurotrophic-factor-within-the-frontal-cortex-and-impaired-behavioral-flexibility-in-both-adolescent-and-adult-rats
#12
Gina M Fernandez, Brandon J Lew, Lindsey C Vedder, Lisa M Savage
Chronic intermittent exposure to ethanol (EtOH; CIE) that produces binge-like levels of intoxication has been associated with age-dependent deficits in cognitive functioning. Male Sprague-Dawley rats were exposed to CIE (5g/kg, 25% EtOH, 13 intragastric gavages) beginning at three ages: early adolescence (postnatal day [PD] 28), mid-adolescence (PD35) and adulthood (PD72). In experiment 1, rats were behaviorally tested following CIE. Spatial memory was not affected by CIE, but adult CIE rats were impaired at acquiring a non-spatial discrimination task and subsequent reversal tasks...
February 28, 2017: Neuroscience
https://www.readbyqxmd.com/read/28257885/production-of-aprepitant-nanocrystals-by-wet-media-milling-and-subsequent-solidification
#13
F Toziopoulou, M Malamatari, I Nikolakakis, K Kachrimanis
The present study investigates the effects of formulation and process parameters on the production of aprepitant nanosuspensions applying wet media milling and subsequent solidification. Six stabilizers were used: two brands of hydroxylpropylmethyl cellulose (HPMC E-15LV and Pharmacoat 603), hydroxypropyl cellulose (HPC-SSL), polyvinylpyrollidone (PVP), D-α-Tocopherol polyethylene glycol 1000 succinate (TPGS 1000), Poloxamer P188 and sodium dodecyl sulfate (SDS), while two diluents (mannitol and sucrose) were incorporated prior to solidification by two methods (spray- and freeze drying)...
February 28, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28257035/rnase-l-suppresses-androgen-receptor-signaling-cell-migration-and-matrix-metalloproteinase-activity-in-prostate-cancer-cells
#14
Shubham Dayal, Jun Zhou, Praveen Manivannan, Mohammad Adnan Siddiqui, Omaima Farid Ahmad, Matthew Clark, Sahezeel Awadia, Rafael Garcia-Mata, Lirim Shemshedini, Krishnamurthy Malathi
The interferon antiviral pathways and prostate cancer genetics converge on a regulated endoribonuclease, RNase L. Positional cloning and linkage studies mapped Hereditary Prostate Cancer 1 (HPC1) to RNASEL. To date, there is no correlation of viral infections with prostate cancer, suggesting that RNase L may play additional roles in tumor suppression. Here, we demonstrate a role of RNase L as a suppressor of androgen receptor (AR) signaling, cell migration and matrix metalloproteinase activity. Using RNase L mutants, we show that its nucleolytic activity is dispensable for both AR signaling and migration...
March 1, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28252235/toll-like-receptor-induced-expression-of-epithelial-cytokine-receptors-on-hemopoietic-progenitors-is-altered-in-allergic-asthma
#15
Damian Tworek, Delia Heroux, Seamus N O'Byrne, Patrick Mitchell, Paul M O'Byrne, Judah A Denburg
BACKGROUND: Hemopoietic progenitor cells (HPC) migrate to sites of allergic inflammation where, upon stimulation with epithelial cytokines, they produce Th2 cytokines and differentiate into mature eosinophils and basophils. They also express Toll-like receptors (TLR) involved in anti-microbial responses. OBJECTIVE: The objective of this study was to compare TLR expression on peripheral blood HPC and TLR-induced responses, in particular changes in epithelial cytokine receptors, in healthy and asthmatic subjects at baseline and following allergen challenge...
March 1, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28238612/6-benzylidene-2-4-pyridin-3-ylcarboxy-benzylidene-cyclohexanones-a-novel-cluster-of-tumour-selective-cytotoxins
#16
Atulya K Panda, Umashankar Das, Naoki Umemura, Hiroshi Sakagami, Masami Kawase, Jan Balzarini, Erik De Clercq, Stephen G Dimmock, Praveen K Roayapalley, Jonathan R Dimmock
Novel cytotoxins 3-5 containing the 1,5-diaryl-3-oxo-1,4-pentadienyl pharmacophore are disclosed. The compounds in series 3 and 5 have the potential to liberate niacin which may reduce some of the side effects of antineoplastic compounds. 3a-c emerged as the most potent cytotoxic compounds with IC50 values in the low micromolar range against human Molt4/C8 and CEM CD4(+) T-lymphocytes as well as murine L1210 leukemia cells. QSAR studies revealed that cytotoxic potencies were negatively correlated with the magnitude of the Hammett sigma values of the aryl substituents...
April 1, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28235601/a-part-of-patients-with-autism-spectrum-disorder-has-haploidy-of-hpc-1-syntaxin1a-gene-that-possibly-causes-behavioral-disturbance-as-in-experimentally-gene-ablated-mice
#17
Takefumi Kofuji, Yuko Hayashi, Tomonori Fujiwara, Masumi Sanada, Masao Tamaru, Kimio Akagawa
Autism spectrum disorder (ASD) is highly heritable and encompasses a various set of neuropsychiatric disorders with a wide-ranging presentation. HPC-1/syntaxin1A (STX1A) encodes a neuronal plasma membrane protein that regulates the secretion of neurotransmitters and neuromodulators. STX1A gene ablated mice (null and heterozygote mutant) exhibit abnormal behavioral profiles similar to human autistic symptoms, accompanied by reduction of monoamine secretion. To determine whether copy number variation of STX1A gene and the change of its expression correlate with ASD as in STX1A gene ablated mice, we performed copy number assay and real-time quantitative RT-PCR using blood or saliva samples from ASD patients...
February 22, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28231381/hippocampal-prefrontal-theta-phase-synchrony-in-planning-of-multi-step-actions-based-on-memory-retrieval
#18
Seiya Ishino, Susumu Takahashi, Masaaki Ogawa, Yoshio Sakurai
Planning of multi-step actions based on the retrieval of acquired information is essential for efficient foraging. The hippocampus (HPC) and prefrontal cortex (PFC) may play critical roles in this process. However, in rodents, many studies investigating such roles utilized T-maze tasks that only require one-step actions (i.e., selection of one of two alternatives), in which memory retrieval and selection of an action based on the retrieval cannot be clearly differentiated. In monkeys, PFC has been suggested to be involved in planning of multi-step actions; however, the synchrony between HPC and PFC has not been evaluated...
February 23, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28230593/hemangiopericytoma-arose-from-the-site-of-meningioma-resection
#19
Xiang Wang, Xiejun Zhang, Qian Zhou, Xiuming Zhou, Lei Chen, Guodong Huang, Weiping Li
Intracranial hemangiopericytoma (HPC) is a rare tumor and accounts for 0.4% of all primary central nervous system tumors. However, it has aggressive behavior in growth and infiltration. The importance of diagnosis and treatment between HPC and meningioma cannot be overemphasized. It is rare that HPC arises from the site of benign meningioma resection. And it would be benefitted to take HPC into account when coming across a patient with meningioma "recurrence."
February 22, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28228091/exploring-the-transcriptome-of-non-model-oleaginous-microalga-dunaliella-tertiolecta-through-high-throughput-sequencing-and-high-performance-computing
#20
Lina Yao, Kenneth Wei Min Tan, Tin Wee Tan, Yuan Kun Lee
BACKGROUND: RNA-Seq technology has received a lot of attention in recent years for microalgal global transcriptomic profiling. It is widely used in transcriptome-wide analysis of gene expression., particularly for microalgal strains with potential as biofuel sources. However, insufficient genomic or transcriptomic information of non-model microalgae has limited the understanding of their regulatory mechanisms and hampered genetic manipulation to enhance biofuel production. As such, an optimal microalgal transcriptomic database construction is a subject of urgent investigation...
February 22, 2017: BMC Bioinformatics
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