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Andrea Mayado, Cristina Teodosio, Noelia Dasilva Freire, Maria Jara-Acevedo, Andrés C Garcia-Montero, Ivan Álvarez-Twose, Laura Sánchez-Muñoz, Almudena Matito, Carolina Caldas, Javier I Muñoz-González, Ana Henriques, José I Sánchez-Gallego, Luis Escribano, Alberto Orfao
BACKGROUND: Recent studies show that most systemic mastocytosis (SM) patients, including indolent SM (ISM) with (ISMs+) and without skin lesions (ISMs-), carry the KIT D816V mutation in PB leukocytes. We investigated the potential association between the degree of involvement of BM hematopoiesis by the KIT D816V mutation and the distribution of different maturation-associated compartments of bone marrow (BM) and peripheral blood (PB) CD34+ hematopoietic precursors (HPC) in ISM, and identified the specific PB cell compartments that carry this mutation...
January 13, 2018: Allergy
Seung Hyuck Jeon, Sung-Hye Park, Jin Wook Kim, Chul-Kee Park, Sun Ha Paek, Il Han Kim
We retrospectively evaluated an efficacy of adjuvant radiotherapy (RT) in the intracranial hemangiopericytoma (HPC) and analyzed prognostic factors influencing treatment outcomes. Among 49 patients diagnosed as localized intracranial HPC between 1995 and 2016, 31 patients received adjuvant RT after surgery; 26 with fractionated RT and 5 with stereotactic radiosurgery using Gamma Knife. After gross total resection (GTR) (n = 32) and subtotal resection (STR) (n = 17), histopathological grade was confirmed to be grade II (n = 9) or grade III (n = 40)...
January 11, 2018: Journal of Neuro-oncology
Bo Yoon Chang, Dae Sung Kim, Hye Soo Kim, Sung Yeon Kim
HPC 03 is herbal formula that consists of extracts from Angelica gigas, Cnidium officinale Makino and Cinnamomum cassia Presl. The present study evaluated the estrogenic potential of HPC 03 by using in vitro and in vivo models. The regulatory mechanisms of HPC 03 in estrogen-dependent MCF-7 cells were assessed. HPC 03 induced the proliferation of estrogen receptor-positive MCF-7 cells, and the proliferation was blocked by the addition of the estrogen antagonist tamoxifen. The estrogen receptorα/β luciferase activities were significantly increased by HPC 03 treatment, which also increased the mRNA expression of the estrogen-responsive genes Psen2, Pgr and Ctsd Also, we evaluated the ameliorative effects of HPC 03 on menopausal symptoms in ovariectomized rats...
February 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
Dariush Naghipour, Seyed Davoud Ashrafi, Ali Mojtahedi, Masoud Vatandoost, Loghman Hosseinzadeh, Esmail Roohbakhsh
In this research, we measured various parameters related to drinking water quality include turbidity, temperature, pH, EC, TDS, Alkalinity, fecal and total coliform, heterotrophic plate count (HPC), free chlorine, Mn, Ca, Mg, Fe, Na, Cl-, F-, HCO3, in the inlet and outlet of household water treatment devices according to the standard methods for the examination of water and wastewater (W.E. Federation and Association and A.P.H., 2005) [1]. Sixty four inlet and outlet water samples were taken from thirty two household water treatment devices from eight different residential blocks in Golsar town of Rasht, Iran...
February 2018: Data in Brief
Kaushalendra Chaturvedi, Bhavin Y Gajera, Ting Xu, Harsh Shah, Rutesh H Dave
The objective of the present study was to investigate the influence of processing methods on the physical and mechanical properties of formulations containing Ibuprofen and HPC-SSL. The powder blends, containing Ibuprofen and HPC-SSL in ratio of 9:0.5, were processed using melt granulation (MG) by hot melt extrusion (HME) and wet granulation (WG) by high shear mixer. Formulated granules and powder blends were compressed into round flat faced tablets using Riva Piccola tablet press. Differential scanning calorimetry (DSC) and X-ray powder diffraction (XRPD) studies proved that granulation process did not significantly alter the crystallinity of Ibuprofen, however particle density and flow properties were significantly improved...
January 9, 2018: Pharmaceutical Development and Technology
Joseph A Carnevale, David J Segar, Andrew Y Powers, Meghal Shah, Cody Doberstein, Benjamin Drapcho, John F Morrison, John R Williams, Scott Collins, Kristina Monteiro, Wael F Asaad
OBJECTIVE Traumatic brain injury (TBI) remains a significant cause of neurological morbidity and mortality. Each year, more than 1.7 million patients present to the emergency department with TBI. The goal of this study was to evaluate the prognosis of traumatic cerebral intraparenchymal hemorrhage (tIPH), to develop subclassifications of these injuries that relate to prognosis, and to provide a more comprehensive assessment of hemorrhagic progression contusion (HPC) by analyzing the rate at which tIPH "blossom" (i...
January 5, 2018: Journal of Neurosurgery
Aminata Kilungo, Linda Powers, Nathan Arnold, Kelli Whelan, Kurt Paterson, Dale Young
The objective of this study was to examine three well designs: drilled wells (20-30 m deep), closed dug wells (>5 m deep), and hand-dug open wells (<5 m deep), to determine the water quality for improving access to safe and clean water in rural communities. Heterotrophic plate count (HPC), total coliforms (TC), Escherichia coli (E. coli) and turbidity, were used to assess the water quality of 97 wells. Additionally, the study looked at the microflora diversity of the water, focusing on potential pathogens using outgrowth, PCR, and genome sequencing for 10 wells...
January 4, 2018: International Journal of Environmental Research and Public Health
Mike Mikailov, Fu-Jyh Luo, Stuart Barkley, Lohit Valleru, Stephen Whitney, Zhichao Liu, Shraddha Thakkar, Weida Tong, Nicholas Petrick
BACKGROUND: Recent breakthroughs in molecular biology and next generation sequencing technologies have led to the expenential growh of the sequence databases. Researchrs use BLAST for processing these sequences. However traditional software parallelization techniques (threads, message passing interface) applied in newer versios of BLAST are not adequate for processing these sequences in timely manner. METHODS: A new method for array job parallelization has been developed which offers O(T) theoretical speed-up in comparison to multi-threading and MPI techniques...
December 28, 2017: BMC Bioinformatics
Nichole M Neugebauer, Masanori Miyauchi, Tatsuya Sato, Jun Tadano, Hanife Akal, Hossein Ardehali, Herbert Y Meltzer
BACKGROUND: Abnormalities in prefrontal cortical and hippocampal GABAergic function are postulated to be major causes of the cognitive impairment associated with schizophrenia (CIAS). There are conflicting views on whether diminished or enhanced GABAergic activity contributes to the deficit in short-term novel object recognition (NOR) in the sub-chronic phencyclidine (scPCP) rodent model of CIAS. This study assessed the role of GABAA signaling in the medial prefrontal cortex (mPFC) and ventral hippocampus (vHPC) in NOR in saline (scSAL)- and scPCP-treated rats...
December 28, 2017: Behavioural Brain Research
J Serrano-Lopez, K Nattamai, N A Pease, M S Shephard, A M Wellendorf, M Sertorio, E A Smith, H Geiger, S I Wells, J A Cancelas, L M Privette Vinnedge
Self-renewing hematopoietic stem cells and multipotent progenitor cells are responsible for maintaining hematopoiesis throughout an individual's lifetime. For overall health and survival, it is critically important that the genome stability of these cells is maintained and that the cell population is not exhausted. Previous reports have demonstrated that the DEK protein, a chromatin structural protein that functions in numerous nuclear processes, is required for DNA damage repair in vitro and long-term engraftment of hematopoietic stem cells in vivo...
December 27, 2017: Experimental Hematology
Jiangchun Wu, Ruobing Wang, Dianxu Yang, Wenbin Tang, Zeli Chen, Qinglei Sun, Lin Liu, Rongyu Zang
Retinal ischemia/reperfusion injury (IRI) plays a crucial role in the pathophysiology of various ocular diseases. Our previous study have shown that postconditioning with inhaled hydrogen (H2) (HPC) can protect retinal ganglion cells (RGCs) in a rat model of retinal IRI. Our further study aims to investigate potential mechanisms underlying HPC-induced protection. Retinal IRI was performed on the right eyes of rats and was followed by inhalation of 67% H2 mixed with 33% oxygen immediately after ischemia for 1 h daily for one week...
December 27, 2017: Biochemical and Biophysical Research Communications
Yiyan Liu
Bone hemangiopericytoma (HPC) is extremely rare, and its clinical manifestations and radiographic features are nonspecific. There are few case reports about application of F18-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in HPC. A total of four subjects with pathologically diagnosed bone HPC had FDG PET/CT for staging and/or restaging bone HPC. Medical records were retrospectively reviewed for radiological, pathological and follow-up information. All primary bone and metastatic lesions demonstrated high FDG avidity on PET/CT, which also revealed the adjacent soft tissue involvement and synchronous lesion...
December 2017: Molecular and Clinical Oncology
Adam Bria, Jorgessen Marda, Junmei Zhou, Xiaowei Sun, Qi Cao, Bryon E Petersen, Liya Pi
The liver possesses an extraordinary ability to regenerate after injury. Hepatocyte-driven liver regeneration is the default pathway in response to mild-to-moderate acute liver damage. When replication of mature hepatocytes is blocked, facultative hepatic progenitor cells (HPCs), also referred to as oval cells (OCs) in rodents, are activated. HPC/OCs have the ability to proliferate clonogenically and differentiate into several lineages including hepatocytes and bile ductal epithelia. This is a conserved liver injury response that has been studied in many species ranging from mammals (rat, mouse, and human) to fish...
September 2017: Liver Research
Mari-Liis Kauts, Carmen Rodriguez-Seoane, Polynikis Kaimakis, Sandra C Mendes, Xabier Cortés-Lavaud, Undine Hill, Elaine Dzierzak
In vivo hematopoietic generation occurs in waves of primitive and definitive cell emergence. Differentiation cultures of pluripotent embryonic stem cells (ESCs) offer an accessible source of hematopoietic cells for blood-related research and therapeutic strategies. However, despite many approaches, it remains a goal to robustly generate hematopoietic progenitor and stem cells (HP/SCs) in vitro from ESCs. This is partly due to the inability to efficiently promote, enrich, and/or molecularly direct hematopoietic emergence...
December 15, 2017: Stem Cell Reports
Zhiyu Li, JinHee Kim, Fred E Regnier
The objective in routine analyses is generally to determine a small number of analytes. With samples containing ~103 or more components there will be insufficient peak capacity to resolve analytes from non-analytes. This issue was addressed herein through a new type of separation mechanism in which small groups of targeted analytes are bound with high affinity to a soluble analyte sequestering transport phase (ASTP) composed of a ~25 nm Stokes radius hydrophilic polymer core (HPC). When introduced into a 30 nm pore diameter size exclusion chromatography (SEC) column ASTP:analyte complexes elute within minutes, together, unretained, and relatively pure in the first chromatographic peak...
December 20, 2017: Analytical Chemistry
Rosemary Bateta, Jingwen Wang, Yineng Wu, Brian L Weiss, Wesley C Warren, Grace A Murilla, Serap Aksoy, Paul O Mireji
BACKGROUND: Tsetse flies (Glossina spp.) are the prominent vector of African trypanosome parasites (Trypanosoma spp.) in sub-Saharan Africa, and Glossina pallidipes is the most widely distributed species in Kenya. This species displays strong resistance to infection by parasites, which are typically eliminated in the midgut shortly after acquisition from the mammalian host. Although extensive molecular information on immunity for the related species Glossina morsitans morsitans exists, similar information is scarce for G...
December 19, 2017: Parasites & Vectors
Xia Wu, Feng Zhang, Peng Hu, Lumin Chen, Guocan Han, Weixian Bai, Jingfeng Luo, Ran Chen, Yurong Zhou, Jihong Sun, Xiaoming Yang
A novel, minimally invasive interventional technique, radiofrequency heat (RFH), has been suggested to improve the efficacy of chemotherapy for solid organ tumors. However, the treatment for prostate cancer has not been completely characterized. The aim of the present study was to investigate the in vitro and in vivo efficiency of chemotherapy in combination with RFH for the treatment of prostate cancer. The following four treatment groups were included: i) No treatment (control); ii) RFH-only; iii) chemotherapy (docetaxel)-only; and iv) combination therapy of docetaxel and RFH in human prostate cancer (HPC) cell lines and mice with HPC xenografts...
December 2017: Oncology Letters
Alessandra Natale, Joost Boeckmans, Terry Desmae, Veerle De Boe, Joery De Kock, Tamara Vanhaecke, Vera Rogiers, Robim M Rodrigues
Phospholipidosis is a metabolic disorder characterized by intracellular accumulation of phospholipids. It can be caused by short-term or chronic exposure to cationic amphiphilic drugs (CAD). These compounds bind to phospholipids, leading to inhibition of their degradation and consequently to their accumulation in lysosomes. Drug-induced phospholipidosis (DIPL) is frequently at the basis of discontinuation of drug development and post-market drug withdrawal. Therefore, reliable human-relevant in vitro models must be developed to speed up the identification of compounds that are potential inducers of phospholipidosis...
December 14, 2017: Toxicology Letters
Panagiotis Samaras, Markus F Rütti, Burkhardt Seifert, Helga Bachmann, Urs Schanz, Maya Eisenring, Christoph Renner, Antonia Maria Müller, Adrian Schmidt, Axel Mischo, Ivo Fuchs, Mario Bargetzi, Markus G Manz, Roger Stupp, Ulf Petrausch, Frank Stenner-Liewen
Vinorelbine combined with filgrastim (r-metHuG-CSF) at a dose of 10 µg/kg of body weight (BW) per day is a reliable and well tolerated regimen for mobilization of hematopoietic progenitor cells (HPC) in patients with multiple myeloma. This prospective randomized phase 2 study was initiated to assess the feasibility of a reduced filgrastim dosage. Vinorelbine was combined with either standard dosed filgrastim (10 µg/kg body weight (BW) per day) or reduced dosed filgrastim (5 µg/kg BW per day). Leukapheresis sessions were planned to start at day 8 and were continued until the predefined target amount of 4 x 106 HPC/kg BW was collected...
December 12, 2017: Biology of Blood and Marrow Transplantation
Jacob M Luber, Braden T Tierney, Evan M Cofer, Chirag J Patel, Aleksandar D Kostic
Motivation: Across biology we are seeing rapid developments in scale of data production without a corresponding increase in data analysis capabilities. Results: Here, we present Aether (, an intuitive, easy-to-use, cost-effective, and scalable framework that uses linear programming (LP) to optimally bid on and deploy combinations of underutilized cloud computing resources. Our approach simultaneously minimizes the cost of data analysis and provides an easy transition from users' existing HPC pipelines...
December 8, 2017: Bioinformatics
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