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https://www.readbyqxmd.com/read/29140985/notch-signaling-and-progenitor-ductular-reaction-in-steatohepatitis
#1
Carola M Morell, Romina Fiorotto, Marica Meroni, Aileen Raizner, Barbara Torsello, Massimiliano Cadamuro, Gaia Spagnuolo, Eleanna Kaffe, Salvatore Sutti, Emanuele Albano, Mario Strazzabosco
BACKGROUND AND OBJECTIVE: Persistent hepatic progenitor cells (HPC) activation resulting in ductular reaction (DR) is responsible for pathologic liver repair in cholangiopathies. Also, HPC/DR expansion correlates with fibrosis in several chronic liver diseases, including steatohepatitis. Increasing evidence indicates Notch signaling as a key regulator of HPC/DR response in biliary and more in general liver injuries. Therefore, we aimed to investigate the role of Notch during HPC/DR activation in a mouse model of steatohepatitis...
2017: PloS One
https://www.readbyqxmd.com/read/29139159/syntaxin1b-contributes-to-regulation-of-the-dopaminergic-system-through-gaba-transmission-in-the-cns
#2
Tomonori Fujiwara, Takefumi Kofuji, Tatsuya Mishima, Kimio Akagawa
In neuronal plasma membrane, two syntaxin isoforms, HPC-1/syntaxin1A (STX1A) and syntaxin1B (STX1B), are predominantly expressed as soluble N-ethylmaleimide-sensitive fusion attachment protein receptors, also known as t-SNAREs. We previously reported that glutamatergic and GABAergic synaptic transmission is impaired in Stx1b null mutant (Stx1b(-/-) ) mice, but is almost normal in Stx1a null mutant (Stx1a(-/-) ) mice. These observations suggested that STX1A and STX1B have distinct functions in fast synaptic transmission in the central nervous system (CNS)...
November 15, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29130518/automated-red-blood-cell-exchange-in-preparation-for-filgrastim-mobilization-of-autologous-peripheral-blood-hematopoietic-progenitor-cells-in-a-patient-with-sickle-cell-anemia
#3
Yong Zhao, Jeffrey A Bailey, Jeanne Linden, Patricia St Pierre, Jan Cerny, Michelle Vauthrin, Mindy Greene, Robert Weinstein
Increasing survival of patients with sickle cell anemia (SCA) well into adulthood results in a rising likelihood of developing hematological malignancy. High-dose chemotherapy with autologous hematopoietic progenitor cell (HPC) rescue is standard of care for several hematological malignancies, but the risk of severe or life-threatening vaso-occlusive phenomena during filgrastim mobilization of HPC for collection poses a potential barrier to this approach. We report the use of automated red cell exchange in preparation for filgrastim mobilization in a patient with homozygous SCA...
November 11, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/29127512/surgical-management-of-spinal-solitary-fibrous-tumor-hemangiopericytoma-a-case-series-of-20-patients
#4
Qi Jia, Zhenhua Zhou, Dan Zhang, Jian Yang, Chao Liu, Ting Wang, Zhipeng Wu, Cheng Yang, Haifeng Wei, Jian Zhao, Tielong Liu, Wang Zhou, Xinghai Yang, Jianru Xiao
PURPOSE: Spinal solitary fibrous tumor/hemangiopericytoma (SFT/HPC), a rare mesenchymal tumor that arises from pericytes of Zimmerman, comprises only 0.08% of all primary bone tumors and 0.1% of primary malignant bone tumor and rarely occurs in the spine. We attempt to correlate the clinical factors and different treatment options with the recurrence rate and overall survival of SFT/HPC over time. METHODS: A retrospective study of 20 patients with spinal osseous SFT/HPCs who were surgically treated in our center between 2003 and 2015 was performed...
November 10, 2017: European Spine Journal
https://www.readbyqxmd.com/read/29123927/locus-coeruleus-and-dopamine-dependent-memory-consolidation
#5
REVIEW
Miwako Yamasaki, Tomonori Takeuchi
Most everyday memories including many episodic-like memories that we may form automatically in the hippocampus (HPC) are forgotten, while some of them are retained for a long time by a memory stabilization process, called initial memory consolidation. Specifically, the retention of everyday memory is enhanced, in humans and animals, when something novel happens shortly before or after the time of encoding. Converging evidence has indicated that dopamine (DA) signaling via D1/D5 receptors in HPC is required for persistence of synaptic plasticity and memory, thereby playing an important role in the novelty-associated memory enhancement...
2017: Neural Plasticity
https://www.readbyqxmd.com/read/29118156/distribution-of-bacteria-in-dental-offices-and-the-impact-of-hydrogen-peroxide-disinfecting-wipes
#6
Charles P Gerba, Gerardo U Lopez, Luisa A Ikner
Purpose: The purpose of this study was to characterize the occurrence of heterotrophic plate count bacteria (HPCs), fecal bacterial indicators, and methicillin-resistant Staphylococcus aureus (MRSA) on hard, nonporous surfaces (fomites) commonly found in dental offices, and to assess the impact of a hygienic disinfection intervention on the reduction of these bacteria in the office setting.Methods: Samples of various fomites were collected from dental offices located in Arizona (6) and Illinois (4) and assayed for HPCs, total coliforms, Escherichia coli, and MRSA in order to establish baseline bacterial levels...
December 2016: Journal of Dental Hygiene: JDH
https://www.readbyqxmd.com/read/29111400/comparison-of-biofilm-cell-quantification-methods-for-drinking-water-distribution-systems
#7
Sharon A Waller, Aaron I Packman, Martina Hausner
Drinking water quality typically degrades after treatment during conveyance through the distribution system. Potential causes include biofilm growth in distribution pipes which may result in pathogen retention, inhibited disinfectant diffusion, and proliferation of bad tastes and odors. However, there is no standard method for direct measurement of biofilms or quantification of biofilm cells in drinking water distribution systems. Three methods are compared here for quantification of biofilm cells grown in pipe loops samplers: biofilm heterotrophic plate count (HPC), biofilm biovolume by confocal laser scanning microscopy (CLSM) and biofilm total cell count by flow cytometry (FCM) paired with Syto 9...
October 27, 2017: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/29102591/hippocampal-gene-expression-patterns-in-oxytocin-male-knockout-mice-are-related-to-impaired-social-interaction
#8
Virginia Meneghini Lazzari, Josi Maria Zimmermann-Peruzatto, Grasiela Agnes, Roberta Oriques Becker, Ana Carolina de Moura, Silvana Almeida, Renata Padilha Guedes, Marcia Giovenardi
Social interaction between animals is crucial for the survival and life in groups. It is well demonstrated that oxytocin (OT) and vasopressin (AVP) play critical roles in the regulation of social behaviors in mammals, however, other neurotransmitters and hormones are involved in the brain circuitry related to these behaviors. The present study aimed to investigate the gene expression of neurotransmitter receptors in the brain of OT knockout (OTKO) male mice. In this study, we evaluated the expression levels of the OT receptor (Oxtr), AVP receptors 1a and 1b (Avpr1a; Avpr1b), dopamine receptor 2 (Drd2), and the estrogen receptors alpha and beta (Esr1; Esr2) genes in the hippocampus (HPC), olfactory bulb (OB), hypothalamus (HPT) and prefrontal cortex (PFC)...
November 1, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29100558/immunohaematological-complications-in-patients-with-sickle-cell-disease-after-haemopoietic-progenitor-cell-transplantation-a-prospective-single-centre-observational-study
#9
Elizabeth S Allen, Kshitij Srivastava, Matthew M Hsieh, Courtney D Fitzhugh, Harvey G Klein, John F Tisdale, Willy A Flegel
BACKGROUND: Haemopoietic progenitor cell (HPC) transplantation can cure sickle cell disease. Non-myeloablative conditioning typically results in donor-derived erythrocytes and stable mixed chimerism of recipient-derived and donor-derived leucocytes. Exposure to donor antigens from the HPC graft and new red cell antibodies induced by transfusion can lead to immunohaematological complications. We assessed the incidence of such complications among HPC transplant recipients with sickle cell disease...
November 2017: Lancet Haematology
https://www.readbyqxmd.com/read/29095436/rna-sequencing-based-comparative-analysis-of-human-hepatic-progenitor-cells-and-their-niche-from-alcoholic-steatohepatitis-livers
#10
An Ceulemans, Stefaan Verhulst, Matthias Van Haele, Olivier Govaere, Juan-Jose Ventura, Leo A van Grunsven, Tania Roskams
Hepatic progenitor cells (HPCs) are small cells with a relative large oval nucleus and a scanty cytoplasm situated in the canals of Hering that express markers of (immature) hepatocytes and cholangiocytes. HPCs are present in large numbers in alcoholic steatohepatitis (ASH), one of the leading causes of chronic liver disease. To date, the mechanisms responsible for proliferation and differentiation of human HPCs are still poorly understood and the role of HPCs in ASH development is unknown. In this study, we aimed to characterise human HPCs and their interactions with other cells through comparison, on both protein and RNA level, of HPC-enriched cell populations from adult human liver tissue using different isolation methods...
November 2, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29094480/myocardial-infarction-does-not-affect-circulating-hematopoietic-stem-and-progenitor-cell-self-renewal-ability-in-a-rat-model
#11
J M Kröpfl, C M Spengler, A Frobert, G Ajalbert, M N Giraud
Due to the importance of peripheral blood hematopoietic stem and progenitor cells (HPCs) in post-acute regeneration after acute myocardial infarction (MI), the present study aimed to investigate count and secondary replating capacity/self-renewal ability of HPCs in peripheral blood before and two weeks after MI. In nine female Lewis inbred rats (n = 9), myocardial infarction was induced by ligation of the left coronary artery while another nine had surgery without ligation for control purposes. Myocardial infarction was confirmed by troponin I concentrations 24 h after MI...
November 2, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/29089934/prebiotic-and-synbiotic-modifications-of-beta-oxidation-and-lipogenic-gene-expression-after-experimental-hypercholesterolemia-in-rat-liver
#12
Claudia C Alves, Dan L Waitzberg, Laila S de Andrade, Laís Dos Santos Aguiar, Milene B Reis, Camila C Guanabara, Odair A Júnior, Daniel A Ribeiro, Priscila Sala
Background and aims: Non-alcoholic fatty liver disease (NAFLD) is characterized by the presence of fat in hepatocytes because of decreased β-oxidation and increased lipogenesis. Prebiotics, probiotics, and synbiotic have modulatory effects on intestinal microbiota and may influence the gut-liver axis. Our aim was to evaluate the effects of prebiotic, probiotics, and synbiotic on liver histopathology and gene expression related to β-oxidation and lipogenesis after hypercholesterolemia. Methods: Wistar male adult rats (n = 40) were submitted to hypercholesterolemic conditions (HPC) (60 days)...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29079799/emergence-of-early-alterations-in-network-oscillations-and-functional-connectivity-in-a-tau-seeding-mouse-model-of-alzheimer-s-disease-pathology
#13
A Ahnaou, D Moechars, L Raeymaekers, R Biermans, N V Manyakov, A Bottelbergs, C Wintmolders, K Van Kolen, T Van De Casteele, J A Kemp, W H Drinkenburg
Synaptic dysfunction and disconnectivity are core deficits in Alzheimer's disease (AD), preceding clear changes in histopathology and cognitive functioning. Here, the early and late effects of tau pathology induction on functional network connectivity were investigated in P301L mice. Multichannel EEG oscillations were used to compute (1) coherent activity between the prefrontal cortex (PFC) and hippocampus (HPC) CA1-CA3 networks; (2) phase-amplitude cross frequency coupling (PAC) between theta and gamma oscillations, which is instrumental in adequate cognitive functioning; (3) information processing as assessed by auditory evoked potentials and oscillations in the passive oddball mismatch negativity-like (MMN) paradigm...
October 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29072456/hierarchically-porous-carbon-derived-from-polyhipe-for-supercapacitor-and-deionization-applications
#14
Wei Hu, Feifei Xie, Yuquan Li, Zhengchen Wu, Ke Tian, Miao Wang, Likun Pan, Lei Li
Hierarchically porous carbon (HPC) materials with interconnected porous texture are produced from a porous poly(divinylbenzene) precursor, which is synthesized by polymerizing high-internal-phase emulsions. After carbonation, the macroporous structures of the poly(divinylbenzene) precursor are preserved and enormous micro-/mesopores via carbonation with KOH are produced, resulting in an interconnected hierarchically porous network. The prepared HPC has a maximum specific surface area of 2189 m(2) g(-1). The electrode materials for supercapacitors and capacitive deionization devices employing the formed HPC exhibit a high specific capacity of 88 mA h g(-1) through a voltage range of 1 V (319 F g(-1) at 1 A g(-1)) and a superior electrosorption capacity of 21...
November 7, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29070040/care-of-the-dialysis-patient-primary-provider-involvement-and-resource-utilization-patterns-a-cohort-study
#15
Bjorg Thorsteinsdottir, Priya Ramar, LaTonya J Hickson, Megan S Reinalda, Robert C Albright, Jon C Tilburt, Amy W Williams, Paul Y Takahashi, Molly M Jeffery, Nilay D Shah
BACKGROUND: Efficient and safe delivery of care to dialysis patients is essential. Concerns have been raised regarding the ability of accountable care organizations to adequately serve this high-risk population. Little is known about primary care involvement in the care of dialysis patients. This study sought to describe the extent of primary care provider (PCP) involvement in the care of hemodialysis patients and the outcomes associated with that involvement. METHODS: In a retrospective cohort study, patients accessing a Midwestern dialysis network from 2001 to 2010 linked to United States Renal Database System and with >90 days follow up were identified (n = 2985)...
October 25, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/29066481/acetylsalicylic-acid-during-leukapheresis-reduces-the-incidence-of-clotting-in-hematopoietic-progenitor-cell-products
#16
Soumya Pandey, Michele Cottler-Fox
INTRODUCTION: Clots may be seen during hematopoietic progenitor cell (HPC) collection or on product arrival to the cell therapy processing laboratory. We have always given one 81 mg acetylsalicylic acid (ASA) when clotting is seen during collection if there is no allergy, but hypothesized that the incidence of clotting would decrease if ASA was given to all autologous collectors with a platelet count of ≥80×10(9)/L prior to collection (pre-emptively). METHODS: Autologous HPC were collected using the Spectra Optia instrument or Cobe Spectra instrument (Terumo BCT(®), Lakewood, CO) with heparinized citrate...
September 2017: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/29054542/cortical-hippocampal-functional-connectivity-during-covert-consolidation-sub-serves-associative-learning-evidence-for-an-active-rest-state
#17
Mathura Ravishankar, Alexandra Morris, Ashley Burgess, Dalal Khatib, Jeffrey A Stanley, Vaibhav A Diwadkar
We studied modulation of undirected functional connectivity (uFC) in cortical-hippocampal sub-networks during associative learning. Nineteen healthy individuals were studied (fMRI acquired on a Siemens Verio 3T), and uFC was studied between nodes in a network of regions identified by standard activation models based on bivariate correlational analyses of time series data. The paradigm alternated between Memory Encoding, Rest and Retrieval. "Rest" intervals promoted covert consolidation. Over the task, performance was broadly separable into linear (Early) and asymptomatic (Late) regimes, with late performance reflecting successful memory consolidation...
October 18, 2017: Brain and Cognition
https://www.readbyqxmd.com/read/29049339/reliability-of-transcardiopulmonary-thermodilution-cardiac-output-measurement-in-experimental-aortic-valve-insufficiency
#18
Martin Petzoldt, Constantin J Trepte, Jan Ridder, Stefan Maisch, Philipp Klapsing, Jan F Kersten, Hans Peter Richter, Jens C Kubitz, Daniel A Reuter, Matthias S Goepfert
BACKGROUND: Monitoring cardiac output (CO) is important to optimize hemodynamic function in critically ill patients. The prevalence of aortic valve insufficiency (AI) is rising in the aging population. However, reliability of CO monitoring techniques in AI is unknown. The aim of this study was to investigate the impact of AI on accuracy, precision, and trending ability of transcardiopulmonary thermodilution-derived COTCPTD in comparison with pulmonary artery catheter thermodilution COPAC...
2017: PloS One
https://www.readbyqxmd.com/read/29049281/unmet-needs-for-analyzing-biological-big-data-a-survey-of-704-nsf-principal-investigators
#19
Lindsay Barone, Jason Williams, David Micklos
In a 2016 survey of 704 National Science Foundation (NSF) Biological Sciences Directorate principal investigators (BIO PIs), nearly 90% indicated they are currently or will soon be analyzing large data sets. BIO PIs considered a range of computational needs important to their work, including high performance computing (HPC), bioinformatics support, multistep workflows, updated analysis software, and the ability to store, share, and publish data. Previous studies in the United States and Canada emphasized infrastructure needs...
October 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/29045779/hierarchically-porous-graphitic-carbon-with-simultaneously-high-surface-area-and-colossal-pore-volume-engineered-via-ice-templating
#20
Luis Estevez, Venkateshkumar Prabhakaran, Adam L Garcia, Yongsoon Shin, Jinhui Tao, Ashleigh M Schwarz, Jens Darsell, Priyanka Bhattacharya, Vaithiyalingam Shutthanandan, Ji-Guang Zhang
Developing hierarchical porous carbon (HPC) materials with competing textural characteristics such as surface area and pore volume in one material is difficult to accomplish-particularly for an atomically ordered graphitic carbon. Herein we describe a synthesis strategy to engineer tunable HPC materials across micro- meso- and macroporous length scales, allowing the fabrication of a graphitic HPC material (HPC-G) with both very high surface area (>2500 m(2)/g) and pore volume (>11 cm(3)/g), the combination of which has not been attained previously...
October 18, 2017: ACS Nano
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