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https://www.readbyqxmd.com/read/28204814/fisetin-regulates-astrocyte-migration-and-proliferation-in%C3%A2-vitro
#1
Nan Wang, Fang Yao, Ke Li, Lanlan Zhang, Guo Yin, Mingjun Du, Bingyi Wu
Fisetin (3,3',4',7-tetrahydroxyflavone) is a plant flavonol found in fruits and vegetables that has been reported to inhibit migration and proliferation in several types of cancer. Reactive astrogliosis involves astrocyte migration and proliferation, and contributes to the formation of glial scars in central nervous system (CNS) disorders. However, the effect of fisetin on the migration and proliferation of astrocytes remains unclear. In this study, we found that fisetin inhibited astrocyte migration in a scratch-wound assay and diminished the phosphorylation of focal adhesion kinase (FAK; Tyr576/577 and paxillin (Tyr118)...
February 15, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28154522/metal-dyshomeostasis-and-their-pathological-role-in-prion-and-prion-like-diseases-the-basis-for-a-nutritional-approach
#2
REVIEW
Mattia Toni, Maria L Massimino, Agnese De Mario, Elisa Angiulli, Enzo Spisni
Metal ions are key elements in organisms' life acting like cofactors of many enzymes but they can also be potentially dangerous for the cell participating in redox reactions that lead to the formation of reactive oxygen species (ROS). Any factor inducing or limiting a metal dyshomeostasis, ROS production and cell injury may contribute to the onset of neurodegenerative diseases or play a neuroprotective action. Transmissible spongiform encephalopathies (TSEs), also known as prion diseases, are a group of fatal neurodegenerative disorders affecting the central nervous system (CNS) of human and other mammalian species...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28091927/effect-of-new-antiviral-agent-camphecin-on-behavior-of-mice
#3
A V Babina, V A Lavrinenko, O I Yarovaya, N F Salakhutdinov
We studied the effect of camphecin (1,7,7-trimethylbicyclo[2.2.1]heptan-2-ylidene-aminoethanol) on mouse behavior in the open-field test. Camphecin possesses antiviral activity and inhibits viral replication, but its influence on the nervous system is poorly studied. Single camphecin injection produced no significant changes in behavioral patterns. Chronic camphecin administration (5 times over 2 weeks) to mice of different strains had no significant influence on open field behavior (motor, exploratory activity, anxiety, emotional state and vegetative functions)...
January 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27951614/nerve-sparing-and-surgery-for-deep-infiltrating-endometriosis-pessimism-of-the-intellect-or-optimism-of-the-will
#4
Basma Darwish, Horace Roman
Nerve-sparing surgery is an emerging technique for surgery-related dysfunction. Within the past 15 years, an essential progress in recognition and understanding of the anatomy of the pelvic autonomous nervous system has been made. Surgical preservation of vegetative nerves has become well known in many cancer centers. The technique has led to improvement of the quality of life following oncologic radical procedures. Positive results have led to the adoption of such techniques in the surgical treatment of deep infiltrating endometriosis in an aim to prevent urinary, rectal, and sexual dysfunction...
January 2017: Seminars in Reproductive Medicine
https://www.readbyqxmd.com/read/27933574/-long-term-hrv-analysis-shows-stress-reduction-by-magnesium-intake
#5
Elmar Wienecke, Claudia Nolden
BACKGROUND: Mental pressure and stress represent an ever-increasing socio-political challenge. The heart rate variability (HRV) measurement, which has its origin in the cardiac function diagnosis, gives information on the neurovegetative activity. A low HRV shows an imbalance of the sympathetic and parasympathetic efferents and thus is an indicator of stress. METHOD: A randomized, controlled, two-armed parallel study with 100 participants and a period of 90 days was performed...
December 2016: MMW Fortschritte der Medizin
https://www.readbyqxmd.com/read/27891602/cannabimimetic-phytochemicals-in-the-diet-an-evolutionary-link-to-food-selection-and-metabolic-stress-adaptation
#6
REVIEW
Jürg Gertsch
The endocannabinoid system (ECS) is a major lipid signalling network that plays important pro-homeostatic (allostatic) roles not only in the nervous system but also in peripheral organs. There is increasing evidence that there is a dietary component in the modulation of the ECS. Cannabinoid receptors in hominids co-evolved with diet, and the ECS constitutes a feedback loop for food selection and energy metabolism. Here, it is postulated that the mismatch of ancient lipid genes of hunter-gatherers and pastoralists with the high-carbohydrate diet introduced by agriculture could be compensated for via dietary modulation of the ECS...
November 27, 2016: British Journal of Pharmacology
https://www.readbyqxmd.com/read/27889752/dietary-and-alcohol-intake-and-central-nervous-system-tumors-in-adults-results-of-the-cerenat-multicenter-case-control-study
#7
Benjamin Allès, Camille Pouchieu, Anne Gruber, Pierre Lebailly, Hugues Loiseau, Pascale Fabbro-Peray, Luc Letenneur, Isabelle Baldi
BACKGROUND: Little is known about the relationship between diet and central nervous system (CNS) tumors, especially in terms of their histological subtypes. This study investigated the overall associations between food groups, alcohol intake and CNS tumors, and in particular about the associations between neuroepithelial tumors and meningiomas. METHODS: Data were collected through the CERENAT (CEREbral tumors: a NATional study) case-control study conducted in France during the period 2004-2010...
2016: Neuroepidemiology
https://www.readbyqxmd.com/read/27810179/diurnal-and-nocturnal-cardiovascular-variability-and-heart-rate-arousal-response-in-idiopathic-hypersomnia
#8
Emilia Sforza, Frédéric Roche, Jean Claude Barthélémy, Vincent Pichot
OBJECTIVES: Autonomic nervous system dysfunction has been described in narcolepsy with cataplexy affecting sympathetic functions. In this study we analyzed whether altered diurnal and nocturnal cardiovascular control is present in idiopathic hypersomnia (IH). METHODS: Fourteen drug-free patients aged 26.2 ± 7 years and 14 age-matched controls were examined. Clinical data, 24-h polysomnography, heart rate (HR) variability, and the HR response to spontaneous arousal were available...
August 2016: Sleep Medicine
https://www.readbyqxmd.com/read/27793778/aav-mediated-gene-delivery-attenuates-neuroinflammation-in-feline-sandhoff-disease
#9
Allison M Bradbury, Tiffany A Peterson, Amanda L Gross, Stephen Z Wells, Victoria J McCurdy, Karen G Wolfe, John C Dennis, Brandon L Brunson, Heather Gray-Edwards, Ashley N Randle, Aime K Johnson, Edward E Morrison, Nancy R Cox, Henry J Baker, Miguel Sena-Esteves, Douglas R Martin
Sandhoff disease (SD) is a lysosomal storage disorder characterized by the absence of hydrolytic enzyme β-N-acetylhexosaminidase (Hex), which results in storage of GM2 ganglioside in neurons and unremitting neurodegeneration. Neuron loss initially affects fine motor skills, but rapidly progresses to loss of all body faculties, a vegetative state, and death by five years of age in humans. A well-established feline model of SD allows characterization of the disease in a large animal model and provides a means to test the safety and efficacy of therapeutic interventions before initiating clinical trials...
January 6, 2017: Neuroscience
https://www.readbyqxmd.com/read/27757935/impact-of-salt-intake-on-the-pathogenesis-and-treatment-of-hypertension
#10
Petra Rust, Cem Ekmekcioglu
Excessive dietary salt (sodium chloride) intake is associated with an increased risk for hypertension, which in turn is especially a major risk factor for stroke and other cardiovascular pathologies, but also kidney diseases. Besides, high salt intake or preference for salty food is discussed to be positive associated with stomach cancer, and according to recent studies probably also obesity risk. On the other hand a reduction of dietary salt intake leads to a considerable reduction in blood pressure, especially in hypertensive patients but to a lesser extent also in normotensives as several meta-analyses of interventional studies have shown...
October 19, 2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27706034/neurodegenerative-diseases-might-citrus-flavonoids-play-a-protective-role
#11
REVIEW
Santa Cirmi, Nadia Ferlazzo, Giovanni E Lombardo, Elvira Ventura-Spagnolo, Sebastiano Gangemi, Gioacchino Calapai, Michele Navarra
Neurodegenerative diseases (ND) result from the gradual and progressive degeneration of the structure and function of the central nervous system or the peripheral nervous system or both. They are characterized by deterioration of neurons and/or myelin sheath, disruption of sensory information transmission and loss of movement control. There is no effective treatment for ND, and the drugs currently marketed are symptom-oriented, albeit with several side effects. Within the past decades, several natural remedies have gained attention as potential neuroprotective drugs...
September 30, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27599807/haemophilus-parainfluenzae-endocarditis-with-systemic-embolisation-following-maxillary-sinusitis
#12
Margarida Barreto Cortes, Vitor Teixeira, Samuel Raimundo Fernandes, Fernanda Rego
The authors present a case of a man with Haemophilus parainfluenzae endocarditis complicated with embolisation to the central nervous system. The patient had no evidence of endocarditis by transoesophageal and transthoracic echocardiograms at baseline, but shortly after developed large mitral valve vegetations with valve rupture. The case highlights how rapidly structural valve damage can ensue despite good clinical and laboratorial antibiotic response.
September 6, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27538603/electrophysiological-assessment-of-nociception-in-patients-with-parkinson-s-disease-a-multi-methods-approach
#13
Janosch A Priebe, Miriam Kunz, Christian Morcinek, Peter Rieckmann, Stefan Lautenbacher
OBJECTIVE: Nociceptive abnormalities indicating increased pain sensitivity have been reported in patients with Parkinson's disease (PD). The disturbances are mostly responsive to dopaminergic (DA) treatment; yet, there are conflicting results. The objective of the present study was to investigate pain processing and nociception in PD patients in a more comprehensive manner than previous studies. For this purpose, a multi-methods approach was used in order to monitor different levels of the central nervous system (spinal, subcortical-vegetative, cortical)...
September 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27538283/-correlation-between-haemostatic-and-vegetate-nervous-system-parameters-under-examination-stress
#14
R I Zhdanov, A N Doinikova, S I Zhdanova, Yu V Chernokhvostov, E S Gadzhieva, V G Dvoenosov
The work is aimed to an assessment of the correlation between of autonomic nervous system tone and the level of reactivity of the students' cardiovascular system and hemostasis system under examination stress. It was found that the students under exam stress are characterized with high values of respiration rate and with lower ones of tidal volume. The value of respiratory minute volume decreases in male students due to the bronchoconstrictor effects of stress at the tracheobronchial tree. This finding confirms a statistically significant reduction in the flow of small, medium and large bronchi, indicating an increased parasympathetic nervous system tone...
March 2016: Zhurnal Vyssheĭ Nervnoĭ Deiatelnosti Imeni I P Pavlova
https://www.readbyqxmd.com/read/27517659/correlation-of-cardiac-troponin-i-levels-with-infective-endocarditis-its-adverse-clinical-outcomes
#15
Zubair Ahmed Thoker, Khursheed Aslam Khan, Imtiyaz Rashid, Zafar
BACKGROUND: To study the association of increased cardiac troponin I levels in infective endocarditis (IE) with its adverse clinical outcomes including in-hospital mortality, perivalvular invasive infection and central nervous system events. METHODS: A prospective cohort study of 26 patients comprising of 19 males and 7 females with an average age of 28years diagnosed with IE using Modified Duke Criteria were taken. A blood sample was drawn from each patient and all samples were analyzed for quantitative estimation of troponin I using ELISA technique...
November 1, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27295518/the-historical-origins-of-the-vegetative-state-received-wisdom-and-the-utility-of-the-text
#16
Zoe M Adams, Joseph J Fins
The persistent vegetative state (PVS) is one of the most iconic and misunderstood phrases in clinical neuroscience. Coined as a diagnostic category by Scottish neurosurgeon Bryan Jennett and American neurologist Fred Plum in 1972, the phrase "vegetative" first appeared in Aristotle's treatise On the Soul (circa mid-fourth century BCE). Aristotle influenced neuroscientists of the nineteenth and early-twentieth centuries, Xavier Bichat and Walter Timme, and informed their conceptions of the vegetative nervous system...
June 13, 2016: Journal of the History of the Neurosciences
https://www.readbyqxmd.com/read/27271831/-correction-of-the-functional-state-of-the-autonomous-nervous-system-in-the-women-presenting-with-the-postmastectomy-syndrome-at-the-stationary-stage-of-the-rehabilitative-treatment
#17
T E Odinets, Yu A Briskin
UNLABELLED: A frequent consequence of the treatment of breast cancer is the postmastectomy syndrome that combines psycho-emotional and functional disorders in various body systems. AIM: The objective of the present study was to evaluate the influence of the program of differential physical rehabilitation on the functional state of the autonomic nervous system in the women with the postmastectomy syndrome at the stationary stage of the rehabilitative treatment. MATERIAL AND METHODS: The study included 50 presenting with the postmastectomy syndrome following radical mastectomy as described by J...
May 2016: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
https://www.readbyqxmd.com/read/27249920/-prophylaxis-of-infiltrative-inflammatory-complications-of-the-wounds-healing-in-patients-operated-on-for-noncomplicated-hernia-of-anterior-abdominal-wall
#18
O P Zhuchenko
The results of investigation of the inflammatory processes dynamics in operative wounds in 238 patients after surgical intervention, performed for noncomplicated hernias of anterior abdominal wall of various localization, as well as the impact of polarized light on correction of the vegetative nervous system disorders, for prophylaxis of infiltrative-purulent complications were analyzed.
January 2016: Klinichna Khirurhiia
https://www.readbyqxmd.com/read/27237579/the-current-situation-on-major-depressive-disorder-in-china-research-on-mechanisms-and-clinical-practice
#19
REVIEW
Zhenghua Hou, Wenhao Jiang, Yingying Yin, Zhijun Zhang, Yonggui Yuan
Depression is the most disabling disorder worldwide that accounts for the highest proportion of global burden attributable to mental disorders. Major depressive disorder (MDD) is characterized by deep sadness, reduced energy, vegetative nervous system dysregulation, cognitive dysfunction, and even a high suicidal tendency. Although other treatment choices are available, antidepressant medication is the front-line treatment option for MDD. Regarding clinical efficacy, only ~50% of patients respond to frontline antidepressants, and <33% obtain remission...
August 2016: Neuroscience Bulletin
https://www.readbyqxmd.com/read/27192850/-characteristics-of-combined-anesthesia-with-epidural-componente-depending-on-vegetative-nervous-system-type
#20
F J Hasanov, A A Aslanov, N F Muradov, K N Namazova
The research objective was to study the characteristics of combined anesthesia with epidural componente (CAEC) depending on vegetative nervous system type (VNS) in patients who underwent large scale traumatic surgical operations on abdominal cavity organs. The scientific research was conducted in Anaesthesiology--Reanimation Department of the Scientific Surgical Centre named after acad. MA. Topchubashev, the Ministry of Health of the Azerbaijan Republic. The research objects were 69 patients who underwent operations in conditions of CAEC due to different serious surgical pathologies of abdominal cavity organs...
January 2016: Anesteziologiia i Reanimatologiia
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