Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#21
JOURNAL ARTICLE
Ramazan Duz
This study aims to investigate the relationship between different phases of bipolar disorder (depressive, manic, and euthymic) and myocardial deformation, assessed by echocardiography, compared to healthy controls. It seeks to elucidate whether these phases of bipolar disorder are associated with different myocardial strain patterns, thus contributing to the understanding of cardiovascular implications in bipolar disorder. A cross-sectional design was employed at Dursun Odabaş Medical Centre, Psychiatry Clinic of Van Yüzüncü Yl University...
March 29, 2024: Medicine (Baltimore)
#22
JOURNAL ARTICLE
Federica Klaus, Hui Xin Ng, Izabela G Barbosa, Alexandra Beunders, Farren Briggs, Katherine E Burdick, Annemieke Dols, Orestes Forlenza, Ariel Gildengers, Caitlin Millett, Benoit H Mulsant, Melis Orhan, Tarek K Rajji, Soham Rej, Martha Sajatovic, Kaylee Sarna, Sigfried Schouws, Ashley Sutherland, Antonio L Teixeira, Joy A Yala, Lisa T Eyler
BACKGROUND: Cognitive deficits in bipolar disorder (BD) impact functioning and are main contributors to disability in older age BD (OABD). We investigated the difference between OABD and age-comparable healthy comparison (HC) participants and, among those with BD, the associations between age, global cognitive performance, symptom severity and functioning using a large, cross-sectional, archival dataset harmonized from 7 international OABD studies. METHODS: Data from the Global Aging and Geriatric Experiments in Bipolar Disorder (GAGE-BD) database, spanning various standardized measures of cognition, functioning and clinical characteristics, were analyzed...
March 26, 2024: Journal of Affective Disorders
#23
JOURNAL ARTICLE
Prateek Uttreja, Ahmed Adel Ali Youssef, Indrajeet Karnik, Kavish Sanil, Nagarjuna Narala, Honghe Wang, Rasha M Elkanayati, Sateesh Kumar Vemula, Michael A Repka
Quetiapine fumarate (QTF) was approved for the treatment of schizophrenia and acute manic episodes. QTF can also be used as an adjunctive treatment for major depressive disorders. QTF oral bioavailability is limited due to its poor aqueous solubility and pre-systemic metabolism. The objective of the current investigation was the formulation development and manufacturing of solid self-nanoemulsifying drug delivery system (S-SNEDDS) formulation through a single-step continuous hot-melt extrusion (HME) process to address these drawbacks...
February 26, 2024: Pharmaceutics
#24
COMPARATIVE STUDY
Valerio Dell'Oste, Lionella Palego, Laura Betti, Sara Fantasia, Davide Gravina, Andrea Bordacchini, Virginia Pedrinelli, Gino Giannaccini, Claudia Carmassi
Post-traumatic stress disorder (PTSD) is a highly disabling mental disorder arising after traumatism exposure, often revealing critical and complex courses when comorbidity with bipolar disorder (BD) occurs. To search for PTSD or depression biomarkers that would help clinicians define BD presentations, this study aimed at preliminarily evaluating circulating brain-derived-neurotrophic factor (BDNF) levels in BD subjects with PTSD or experiencing a major depressive episode versus controls. Two bloodstream BDNF components were specifically investigated, the storage (intraplatelet) and the released (plasma) ones, both as adaptogenic/repair signals during neuroendocrine stress response dynamics...
March 20, 2024: International Journal of Molecular Sciences
#25
REVIEW
Pseudodementia in Patients with Unipolar and Bipolar Disorders: A Case Series and Literature Review.
Camilla Elefante, Giulio Emilio Brancati, Donatella Acierno, Gabriele Pistolesi, Sara Ricciardulli, Francesco Weiss, Francesca Romeo, Lorenzo Lattanzi, Icro Maremmani, Giulio Perugi
Even though pseudodementia has been historically linked to depression, other psychiatric conditions may cause reversible cognitive alterations. The purpose of this study is to improve our understanding of pseudodementia occurring throughout the entire bipolar spectrum. A systematic review was conducted according to PRISMA guidelines. PubMed, Scopus, and Web of Science databases were searched up to March 2023. Fifteen articles on patients with pseudodementia and bipolar disorder (BD), mania, hypomania, or mixed depression have been included...
March 19, 2024: Journal of Clinical Medicine
#26
JOURNAL ARTICLE
Maksymilian Rejek, Błażej Misiak
BACKGROUND: The intricate correlation between environmental exposures and mental health outcomes is increasingly acknowledged in psychiatric research. This study investigated the relationship between cumulative environmental risk factors, as represented by the exposome score (ES), and various domains of psychopathology within a non-clinical sample using a network analysis. METHODS: We recruited 1100 participants (aged 18-35 years, 51.4% females) via a computer-assisted web interview, assessing psychopathological symptoms using standardized questionnaires...
February 29, 2024: Brain Sciences
#27
JOURNAL ARTICLE
M N Dmitriev, D O Baeva, M S Slavgorodskaya
A large number of people who have had COVID-19 have developed mental symptoms and mood disorders. Anxiety and depression prevail among affective pathology. Evidence is accumulating that the Sars-CoV-2 virus can induce mania or hypomania in people with no personal psychopathological history. Some clinical, anamnestic and paraclinical patterns of new-onset mania and hypomania have been found. In cases of severe manic symptoms, it is possible to quickly assume the occurrence of bipolar affective disorder. The predominance of depressive and anxiety syndromes in the long-term disease and the presence of vivid vegetative symptoms can mask brief and syndromally incomplete episodes of hypomania, which distorts the understanding of the disease as a bipolar disorder...
2024: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
#28
JOURNAL ARTICLE
Laura Palagini, Gaspare Alfi, Riccardo Gurrieri, Eric Annuzzi, Valerio Caruso, Matteo Gambini, Giovanna Grenno, Marco Trivella, Silvio Presta, Mario Miniati, Stefano Pini, Giulio Perugi, Angelo Gemignani
Insomnia disorder may affect mental health, increasing suicidal risk. Targeting insomnia is crucial in the clinical practice. Sixty-six consecutive patients with insomnia disorder according with the DSM-5-TR criteria were treated with the dual orexin receptor antagonist, daridorexant 50 mg. Baseline (T0), 1 month (T1) and 3 month (T2) evaluations were performed. Insomnia severity (Insomnia Severity Index), mood, anxiety symptoms and suicidal risk (Beck Depression Inventory-II, Young Mania Rating Scale, Self-Reported Anxiety Scale, Suicidal Ideation Scale), dysfunctional insomnia-cognitive factors and pre-sleep arousal (Dysfunctional Beliefs About Sleep, Pre-Sleep Arousal Scale) were evaluated...
March 24, 2024: Journal of Sleep Research
#29
JOURNAL ARTICLE
Martha Sajatovic, Soham Rej, Osvaldo P Almeida, Kursat Altinbas, Vicent Balanzá-Martínez, Izabela G Barbosa, Alexandra J M Beunders, Hilary P Blumberg, Farren B S Briggs, Annemiek Dols, Brent P Forester, Orestes V Forlenza, Ariel G Gildengers, Esther Jimenez, Federica Klaus, Beny Lafer, Benoit Mulsant, Benson Mwangi, Paula Villela Nunes, Andrew T Olagunju, Stephen Oluwaniyi, Melis Orhan, Regan E Patrick, Joaquim Radua, Tarek Rajji, Kaylee Sarna, Sigfried Schouws, Christian Simhandl, Harmehr Sekhon, Jair C Soares, Ashley N Sutherland, Antonio L Teixeira, Shangying Tsai, Sonia Vidal-Rubio, Eduard Vieta, Joy Yala, Lisa T Eyler
OBJECTIVES: The Global Aging & Geriatric Experiments in Bipolar Disorder Database (GAGE-BD) project pools archival datasets on older age bipolar disorder (OABD). An initial Wave 1 (W1; n = 1369) analysis found both manic and depressive symptoms reduced among older patients. To replicate this finding, we gathered an independent Wave 2 (W2; n = 1232, mean ± standard deviation age 47.2 ± 13.5, 65% women, 49% aged over 50) dataset. DESIGN/METHODS: Using mixed models with random effects for cohort, we examined associations between BD symptoms, somatic burden and age and the contribution of these to functioning in W2 and the combined W1 + W2 sample (n = 2601)...
March 2024: International Journal of Geriatric Psychiatry
#30
Marcelo Francia, Merel Bot, Toni Boltz, Juan F De la Hoz, Marco Boks, René Kahn, Roel Ophoff
Bipolar disorder (BD) is a heritable disorder characterized by shifts in mood that manifest in manic or depressive episodes. Clinical studies have identified abnormalities of the circadian system in BD patients as a hallmark of underlying pathophysiology. Fibroblasts are a well-established in vitro model for measuring circadian patterns. We set out to examine the underlying genetic architecture of circadian rhythm in fibroblasts, with the goal to assess its contribution to the polygenic nature of BD disease risk...
March 5, 2024: bioRxiv
#31
JOURNAL ARTICLE
Fangming Xu, Yu Su, Xiaobo Wang, Tianle Zhang, Tingting Xie, Yumei Wang
STUDY DESIGN: A prospective study. BACKGROUND: This study aims to investigate the relationship between different states of bipolar disorder (BD) and plasma inflammatory proteins, which may be used as their biomarkers. MATERIALS AND METHODS: We totally collected admission plasma from 16 healthy subjects and 32 BD patients, including 16 patients with BD manic episodes (BD-M) and 16 patients with BD depressive episodes (BD-D). Ten samples in each group were analyzed by proximity extension assays of 92 inflammation-related proteins, and all samples were verified by ELISA...
March 13, 2024: International Immunopharmacology
#32
JOURNAL ARTICLE
Rotem Dan, Alexis E Whitton, Michael T Treadway, Ashleigh V Rutherford, Poornima Kumar, Manon L Ironside, Roselinde H Kaiser, Boyu Ren, Diego A Pizzagalli
Clinical assessments often fail to discriminate between unipolar and bipolar depression and identify individuals who will develop future (hypo)manic episodes. To address this challenge, we developed a brain-based graph-theoretical predictive model (GPM) to prospectively map symptoms of anhedonia, impulsivity, and (hypo)mania. Individuals seeking treatment for mood disorders (n = 80) underwent an fMRI scan, including (i) resting-state and (ii) a reinforcement-learning (RL) task. Symptoms were assessed at baseline as well as at 3- and 6-month follow-ups...
March 13, 2024: Neuropsychopharmacology
#33
JOURNAL ARTICLE
Yuan Yang, Tong Guo, Qian Zhao, Yang Li, Teris Cheung, Lei Zhang, Xuequan Zhu, Todd Jackson, Xiao-Hong Li, Yu-Tao Xiang
Bipolar disorder (BD) is a major mental disorder that significantly impairs behavior and social functioning. This study assessed the network structure of prodromal symptoms in patients with BD prior to their index mood episode. Semi-structured interviews were conducted with the Bipolar Prodrome Symptom Scale-Retrospective (BPSS-R) to examine patients' prodromal symptoms. Network analysis was conducted to elucidate inter-relations between prodromal symptoms. A total of 120 eligible patients participated in this study...
March 5, 2024: Psychiatry Research
#34
REVIEW
Jean-Baptiste Belge, Bernard G C C Sabbe
INTRODUCTION: Non-adherence to medication significantly affects bipolar disorder outcomes. Long-Acting Injectable antipsychotics show promise by ensuring adherence and averting relapses. AREAS COVERED: This narrative review sought to evaluate the efficacy of second-generation injectable antipsychotics in bipolar disorder through searches in Embase, MEDLINE, and PsycInfo for randomized controlled trials and mirror-image studies.Risperidone and aripiprazole Long-Acting Injectables demonstrated effectiveness in preventing mood recurrences compared to placebos in adults with bipolar disorder...
March 11, 2024: Expert Opinion on Pharmacotherapy
#35
JOURNAL ARTICLE
Kenneth Graham Drinkwater, Andrew Denovan, Neil Dagnall
Within non-clinical samples the relationship between paranormal belief (PB) and well-being varies as a function of level of psychopathology. Accordingly, believers are best conceptualised as a heterogeneous set of sub-groups. The usefulness of previous findings has been restricted by conceptual methodological limitations. Specifically, overreliance on cross-sectional design, the assumption that believers constitute a homogeneous group, and consideration of direct effects. Acknowledging these limitations, the present study investigated whether profile membership derived from PB and psychopathology (schizotypy and manic-depressive experience) predicted well-being (i...
2024: PloS One
#36
JOURNAL ARTICLE
Nahal Abbasi, Yasaman Mirabzadeh, Golnaz Khesali, Zahra Ebrahimkhani, Hanie Karimi, Salar Vaseghi
BACKGROUND: Rapid-eye movement (REM) sleep deprivation (SD) can induce manic-like behaviors in rodents. On the other hand, lithium, as one of the oldest drugs used in neuropsychiatric disorders, is still one of the best drugs for the treatment and control of bipolar disorder. In this study, we aimed to investigate the role of chronic short-term REM SD in the induction of manic-like behaviors in female rats. METHODS: The rats were exposed to REM SD for 14 days (6 hours/day)...
March 2, 2024: Psychopharmacology
#37
Yuka Shimada, Yasunori Oda, Shintaro Shibata, Yuki Hirose, Tsuyoshi Sasaki
We describe a 32-year-old Japanese female with hypersomnia and bipolar disorder. She had developed hypersomnia and sleep attacks in her teens. She was misdiagnosed with narcolepsy at a neurology department and then received methylphenidate (MPH) for many years. After giving birth, she developed postpartum depression and suffered from mood swings and irritability. Following 10-year treatment with methylphenidate, she experienced MPH-induced psychosis when she was in a manic state. Her psychosis improved rapidly with the cessation of methylphenidate...
January 2024: Curēus
#38
JOURNAL ARTICLE
Fabiana Corsi-Zuelli, Diego Quattrone, Taciana Cristina Carvalho Ragazzi, Camila Marcelino Loureiro, Rosana Shuhama, Paulo Rossi Menezes, Paulo Louzada-Junior, Cristina Marta Del-Ben
BACKGROUND: There is limited evidence as to whether the immune protein profile is associated with a particular symptomatology pattern across the psychosis continuum . METHODS: We estimated two bifactor models of general and specific dimensions of psychotic experiences in unaffected siblings of patients ( n = 52) and community controls ( n = 200), and of psychotic symptoms in first-episode psychosis (FEP) patients ( n = 110). We evaluated associations between these transdiagnostic dimensions and trait (TNF- α , IFN- γ ), state (IL-6, IL-1 β ), and regulatory (TGF- β , IL-10, IL-4) cytokines...
February 28, 2024: Psychological Medicine
#39
JOURNAL ARTICLE
Jin Hong Park, Megan Kummerlowe, David C Fipps, Christopher L Sola
No abstract text is available yet for this article.
March 1, 2024: Journal of ECT
#40
Identifying genetic differences between bipolar disorder and major depression through multiple GWAS.
Georgia Panagiotaropoulou, Kajsa-Lotta Georgii Hellberg, Jonathan R I Coleman, Darsol Seok, Janos Kalman, Philip B Mitchell, Peter R Schofield, Andreas J Forstner, Michael Bauer, Laura J Scott, Carlos N Pato, Michele T Pato, Qingqin S Li, George Kirov, Mikael Landén, Lina Jonsson, Bertram Müller-Myhsok, Jordan W Smoller, Elisabeth B Binder, Tanja M Brückl, Darina Czamara, Sandra Van der Auwera, Hans J Grabe, Georg Homuth, Carsten O Schmidt, James B Potash, Raymond J DePaulo, Fernando S Goes, Dean F MacKinnon, Francis M Mondimore, Myrna M Weissman, Jianxin Shi, Mark A Frye, Joanna M Biernacka, Andreas Reif, Stephanie H Witt, René R Kahn, Marco M Boks, Michael J Owen, Katherine Gordon-Smith, Brittany L Mitchell, Nicholas G Martin, Sarah E Medland, Lisa Jones, James A Knowles, Douglas F Levinson, Michael C O'Donovan, Cathryn M Lewis, Gerome Breen, Thomas Werge, Andrew J Schork, Roel Ophoff, Stephan Ripke, Loes Olde Loohuis
BACKGROUND: Accurate diagnosis of bipolar disorder (BD) is difficult in clinical practice, with an average delay between symptom onset and diagnosis of about 7 years. A key reason is that the first manic episode is often preceded by a depressive one, making it difficult to distinguish BD from unipolar major depressive disorder (MDD). AIMS: Here, we use genome-wide association analyses (GWAS) to identify differential genetic factors and to develop predictors based on polygenic risk scores that may aid early differential diagnosis...
January 30, 2024: medRxiv
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
