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https://www.readbyqxmd.com/read/27931917/co-occurrence-of-marfan-syndrome-and-bipolar-disorder-a-fifteen-year-follow-up
#1
Vijendra Nath Jha, Manoj Kumar, Jatin Tarwani
INTRODUCTION: Marfan syndrome, a chromosomal disorder, has been commonly associated with schizophrenia but no association with Bipolar affective disorder has been reported in the scientific literature. CASE REPORT: This case depicts the occurrence of Bipolar affective disorder in a previously undiagnosed case of Marfan syndrome. DISCUSSION: In this case patient had all manic episodes without any depressive or schizophrenia-like episodes, suggesting a diagnostic stability over a long period of over fifteen years...
December 2016: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/27920534/perceptions-and-impact-of-bipolar-disorder-in-japan-results-of-an-internet-survey
#2
Koichiro Watanabe, Eiji Harada, Takeshi Inoue, Yuka Tanji, Toshiaki Kikuchi
Bipolar disorder is a recurrent and episodic illness. This survey study assessed experiences and identified clinical insights of individuals with bipolar disorder. An Internet-based monitor system database was screened for patients with bipolar disorder in Japan (February and March 2013). Of 1,050 patients, 457 completed surveys, and results were analyzed with descriptive statistics. Approximately one-fourth of respondents were diagnosed with bipolar disorder on their first visit to medical institutions, although the most common initial diagnosis was depression/depressive state (65%)...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27914248/the-difficult-lives-of-individuals-with-bipolar-disorder-a-review-of-functional-outcomes-and-their-implications-for-treatment
#3
REVIEW
Michael J Gitlin, David J Miklowitz
BACKGROUND: Most longitudinal or treatment studies in bipolar disorder have used symptomatic or syndromal status as the primary outcome variable. More recently, psychosocial functioning has been highlighted as a key domain of outcome. Patients with bipolar disorder appear to be impaired in all functional domains, although the factors that cause impairment have not been clearly specified. METHODS: This paper reviews cross-sectional and longitudinal studies on functional impairment and its relationship to symptomatic, neurocognitive, personality, and stress variables in bipolar disorder; and the implications of these relationships for defining treatment targets...
November 22, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27907276/clinical-course-of-methamphetamine-induced-psychotic-disorder-in-a-3-month-follow-up
#4
Sakineh Javadian, Amir Shabani, Seyed Vahid Shariat
Objective: To assess the clinical course of patients with methamphetamine-induced psychotic disorder (MIPD) and any possible predictors of the clinical course in a 3-month follow-up. Methods: This prospective cohort study included 50 patients (7 female, 43 male) with MIPD and was performed from September 2014 to October 2015. Patients were assessed during hospitalization and in a follow-up visit 3 months later. Diagnoses were made using interviews based on the Structured Clinical Interview for DSM-IV Axis I Disorders...
November 3, 2016: Primary Care Companion to CNS Disorders
https://www.readbyqxmd.com/read/27878807/manic-switches-induced-by-antidepressants-an-umbrella-review-comparing-randomized-controlled-trials-and-observational-studies
#5
N Allain, C Leven, B Falissard, J-S Allain, J-M Batail, E Polard, F Montastruc, D Drapier, F Naudet
OBJECTIVE: We aimed to explore whether the prevalence of manic switch was underestimated in randomized controlled trials (RCTs) compared to observational studies (OSs). METHOD: Meta-analyses and simple and systematic reviews were identified by two reviewers in a blinded, standardized manner. All relevant references were extracted to include RCTs and OSs that provided data about manic switch prevalence after antidepressant treatment for a major depressive episode...
November 23, 2016: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/27871720/-guidelines-for-the-prescription-of-mood-stabilizers-for-adolescents-a-literature-review
#6
G Munch, N Godart
INTRODUCTION: Adolescence is a unique phase of the human developmental process. In adolescents, psychotropic medications may have different efficacy and tolerance profiles compared to those at other stages of the lifespan. Mood stabilizers are a complex pharmacological category including lithium, some anticonvulsants, and some second generation antipsychotics. Focusing on this class of pharmacological agents, we aim to answer the following questions: in which indications and according to which modalities should mood stabilizers be prescribed during adolescence? METHODS: Information was sought from the websites of the French Haute Autorité de santé (HAS) and Agence nationale de sécurité du médicament et des produits de santé (ANSM), the American Food and Drug Administration (FDA) and the British National Institute for Health and Clinical Excellence (NICE)...
November 18, 2016: L'Encéphale
https://www.readbyqxmd.com/read/27869049/exclusion-of-overlapping-symptoms-in-dsm-5-mixed-features-specifier-heuristic-diagnostic-and-treatment-implications
#7
Gin S Malhi, Yulisha Byrow, Tim Outhred, Kristina Fritz
This article focuses on the controversial decision to exclude the overlapping symptoms of distractibility, irritability, and psychomotor agitation (DIP) with the introduction of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) mixed features specifier. In order to understand the placement of mixed states within the current classification system, we first review the evolution of mixed states. Then, using Kraepelin's original classification of mixed states, we compare and contrast his conceptualization with modern day definitions...
November 21, 2016: CNS Spectrums
https://www.readbyqxmd.com/read/27864531/familial-depressive-symptoms-and-delinquency-separate-self-reports-from-mothers-and-their-offspring
#8
Lee Ellis, Anthony Hoskin
Research has documented that both unipolar and bipolar depression are positively correlated with involvement in delinquency and crime. The present study sought to broaden the understanding of these relationships by looking for links between offending and family histories of depressive symptoms in relationship to offspring delinquency. More than 6,000 college students and their mothers provided self-reported information regarding feelings of depression. Students provided self-reports of involvement in various categories of offending and drug use from ages 10 through 18...
November 18, 2016: International Journal of Offender Therapy and Comparative Criminology
https://www.readbyqxmd.com/read/27847932/neurochemical-alterations-in-anterior-cingulate-cortex-in-bipolar-disorder-a-proton-magnetic-resonance-spectroscopy-study-1h-mrs
#9
Beata Galińska-Skok, Beata Konarzewska, Bożena Kubas, Eugeniusz Tarasów, Agata Szulc
OBJECTIVES: The aim of this study was to determine neurochemical alterations in bipolar disorder using proton magnetic resonance spectroscopy (1H-MRS). METHODS: We investigated a group of 27 patients diagnosed with bipolar disorder (with manic and mixed episodes, depression and after remission of symptoms) and 10 healthy subjects. MR imaging and 1H-MRS were performed on a 1.5 T scanner. Voxels of 8 cm3 were positioned in the anterior cingulate, left frontal lobe and left temporal lobe...
2016: Psychiatria Polska
https://www.readbyqxmd.com/read/27830449/understanding-early-age-of-onset-a-review-of-the-last-5%C3%A2-years
#10
REVIEW
Gabrielle A Carlson, Caroly Pataki
The age at onset of bipolar disorder ranging from childhood to adolescent to adult has significant implications for frequency, severity and duration of mood episodes, comorbid psychopathology, heritability, response to treatment, and opportunity for early intervention. There is increasing evidence that recognition of prodromal symptoms in at-risk populations and mood type at onset are important variables in understanding the course of this illness in youth. Very early childhood onset of symptoms including anxiety/depression, mood lability, and subthreshold manic symptoms, along with family history of a parent with early onset bipolar disorder, appears to predict the highest risk of early onset disorder with the most severe course...
December 2016: Current Psychiatry Reports
https://www.readbyqxmd.com/read/27824775/evaluation-of-bipolar-disorder-in-children-and-adolescents-referred-to-a-mood-service-diagnostic-pathways-and-manic-dimensions
#11
Ana P Ferreira-Maia, Alexandre C Boronat, Miguel A Boarati, Lee Fu-I, Yuan-Pang Wang
OBJECTIVES: Few studies have examined pediatric mental health services for early-onset bipolar disorder (BD). The goal of this study was to describe diagnostic pathways and manic dimensions in BD among referred children and adolescents. METHODS: Data were obtained from a review of the charts of 814 subjects, 2 to 17 years of age, with a complaint of mood disturbances who were referred between 2003 and 2012 to a university-based child and adolescent clinic that specializes in mood disorders...
November 2016: Journal of Psychiatric Practice
https://www.readbyqxmd.com/read/27816941/the-international-college-of-neuro-psychopharmacology-cinp-treatment-guidelines-for-bipolar-disorder-in-adults-cinp-bd-2017-part-2-review-grading-of-the-evidence-and-a-precise-algorithm
#12
REVIEW
Konstantinos N Fountoulakis, Lakshmi Yatham, Heinz Grunze, Eduard Vieta, Allan Young, Pierre Blier, Siegfried Kasper, Hans Jurgen Moeller
BACKGROUND: The current paper includes the systematic search of the literature, the detailed presentation of the results and the grading of treatment options in terms of efficacy and tolerability/safety. MATERIAL AND METHODS: The PRISMA method was used in the search of the literature with the combination of the words 'bipolar', 'manic', 'mania', 'manic depression' and 'manic depressive' with 'randomized', and 'algorithms' with 'mania', 'manic', 'bipolar', 'manic-depressive' or 'manic depression'...
November 5, 2016: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27810714/symptom-quality-versus-quantity-in-judging-prognosis-using-nesarc-predictive-validators-to-locate-uncomplicated-major-depression-on-the-number-of-symptoms-severity-continuum
#13
Jerome C Wakefield, Mark F Schmitz
BACKGROUND: Uncomplicated major depressive disorder (UMDD) is defined as MDD that does not include any of six pathosuggestive features: more than six months duration, marked functional impairment, sense of worthlessness, suicidal ideation, psychotic ideation, and psychomotor retardation. Complicated MDD (CMDD) includes all episodes containing one or more of these features. UMDD has been shown to be lower than CMDD and indistinguishable from no-MDD-history on predictive pathology validators...
October 14, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27804862/a-magnetic-resonance-spectroscopy-study-of-lovastatin-for-treating-bipolar-mood-disorder-a-4-week-randomized-double-blind-placebo-controlled-clinical-trial
#14
Mehrzad Lotfi, Sara Shafiee, Ahmd Ghanizadeh, Motahar Omrani Sigaroudi, Leila Rzeghian
BACKGROUND: No trial have examined the effect of lovastatin on the brain metabolites in patients with bipolar mood disorder. OBJECTIVES: Current medications for treating bipolar disorders cause metabolic syndrome. it is supposed that lovastatin not only decreases the rate of metabolic syndrome but also impacts some brain metabolitis and their ratio like common treatments that are measured by Magnetic Resonance Spectroscopy . METHODS: 27 manic phase patients were randomly allocated into two groups,lovastatin and placebo as their adjuant medication...
October 28, 2016: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/27800654/biological-hypotheses-and-biomarkers-of-bipolar-disorder
#15
REVIEW
Ekaterina Sigitova, Zdeněk Fišar, Jana Hroudová, Tereza Cikánková, Jiří Raboch
The most common mood disorders are major depressive disorders and bipolar disorders. The pathophysiology of bipolar disorder is complex, multifactorial, and not fully understood. Creation of new hypotheses in the field gives impetus for studies and searching new biomarkers of the bipolar disorder. Conversely, new biomarkers facilitate not only diagnosis of a disorder and monitoring of biological effects of treatment, but also formulation of new hypotheses of the causes and pathophysiology of the bipolar disorder...
October 31, 2016: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/27794254/does-stress-play-a-significant-role-in-bipolar-disorder-a-meta-analysis
#16
REVIEW
Claudia Lex, Eva Bäzner, Thomas D Meyer
BACKGROUND: There is evidence that stressful life events (LE) play a crucial role in the etiology of bipolar affective disorder (BD). However, primary studies, as well as narrative reviews, have provided mixed results. The present meta-analysis combined and analyzed previous data in order to address these inconsistencies. METHOD: Forty-two studies published in 53 records were identified by systematically searching MEDLINE, PsychINFO, and PSYCHINDEX using the terms "bipolar disorder" OR "manic-depressive" OR "bipolar affective disorder" OR "mania" AND "stress" OR "life event" OR "daily hassles" OR "goal attainment"...
October 11, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27794238/l-methylfolate-for-bipolar-i-depressive-episodes-an-open-trial-proof-of-concept-registry
#17
Andrew A Nierenberg, Rebecca Montana, Gustavo Kinrys, Thilo Deckersbach, Steven Dufour, Ji Hyun Baek
BACKGROUND: L-methylfolate is a compelling candidate to treat bipolar I major depressive episodes. While approved as an adjunct for unipolar major depressive disorder, no studies have been done to assess the tolerability, safety, and efficacy of L-methylfolate for bipolar depression. As a first step, we developed a registry of bipolar patients treated with L-methylfolate to examine tolerability and outcomes. METHODS: Subjects (N=10) received treatment as usual plus daily L-methylfolate 15mg for 6 weeks in this open-label registry...
October 1, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27770296/lithium-in-bipolar-disorder-optimizing-therapy-using-prolonged-release-formulations
#18
REVIEW
Paolo Girardi, Roberto Brugnoli, Giovanni Manfredi, Gabriele Sani
Lithium has been a gold standard in the treatment of bipolar disorder (BD) for several decades. Despite a general reduction in the use of lithium over the past several years, it is effective in the management of both manic and depressive episodes in BD and continues to be recommended as a first-line mood stabilizer. This review provides an overview of the pharmacology of lithium and highlights its clinical profile in the management of BD, focusing on the potential advantages of prolonged-release (PR) versus immediate-release (IR) formulations of lithium...
December 2016: Drugs in R&D
https://www.readbyqxmd.com/read/27766498/mood-spectrum-comorbidity-in-patients-with-anorexia-and-bulimia-nervosa
#19
Mario Miniati, Antonella Benvenuti, Elena Bologna, Alessandra Maglio, Biagio Cotugno, Gabriele Massimetti, Simona Calugi, Mauro Mauri, Liliana Dell'Osso
PURPOSE: To investigate the presence of mood spectrum signs and symptoms in patients with anorexia nervosa, restricting subtype (AN-R) or bulimia nervosa (BN). METHOD: 55 consecutive female patients meeting DSM-IV criteria for eating disorders (EDs) not satisfying DSM-IV criteria for Axis I mood disorders were evaluated with the Lifetime Mood Spectrum Self-Report (MOODS-SR) and the Mini-International Neuropsychiatric Interview (MINI). The MOODS-SR explored the subthreshold comorbidity for mood spectrum symptoms in patients not reaching the threshold for a mood disorder Axis I diagnosis...
October 20, 2016: Eating and Weight Disorders: EWD
https://www.readbyqxmd.com/read/27759213/early-report-on-brain-arousal-regulation-in-manic-vs-depressive-episodes-in-bipolar-disorder
#20
Dirk Alexander Wittekind, Janek Spada, Alexander Gross, Tilman Hensch, Philippe Jawinski, Christine Ulke, Christian Sander, Ulrich Hegerl
OBJECTIVES: The arousal regulation model of affective disorders attributes an important role in the pathophysiology of affective disorders to dysregulation of brain arousal regulation. According to this model, sensation avoidance and withdrawal in depression and sensation seeking and hyperactivity in mania can be explained as auto-regulatory attempts to counteract a tonically high (depression) or unstable (mania) arousal. The aim of this study was to compare brain arousal regulation between manic and depressive bipolar patients and healthy controls...
September 2016: Bipolar Disorders
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