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https://www.readbyqxmd.com/read/29027157/animal-models-for-bipolar-disorder-from-bedside-to-the-cage
#1
REVIEW
Dominik K E Beyer, Nadja Freund
Bipolar disorder is characterized by recurrent manic and depressive episodes. Patients suffering from this disorder experience dramatic mood swings with a wide variety of typical behavioral facets, affecting overall activity, energy, sexual behavior, sense of self, self-esteem, circadian rhythm, cognition, and increased risk for suicide. Effective treatment options are limited and diagnosis can be complicated. To overcome these obstacles, a better understanding of the neurobiology underlying bipolar disorder is needed...
October 13, 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/29017623/the-genealogy-of-the-clinical-syndrome-of-mania-signs-and-symptoms-described-in-psychiatric-texts-from-1880-to-1900
#2
K S Kendler
In 1800, mania was conceptualized as an agitated psychotic state. By 1900, it closely resembled its modern form. This paper reviews the descriptions of mania in Western psychiatry from 1880 to 1900, when Kraepelin was training and developing his concept of manic-depressive illness. Psychiatric textbooks published 1900-1960 described 22 characteristic manic symptoms/signs the presence of which were recorded in 25 psychiatric textbooks and three other key documents published 1880-1900. Descriptions of mania in these nineteenth century textbooks closely resembled those in the twentieth century, recording a mean (s...
October 11, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/29017197/-500-years-of-reformation-the-history-of-martin-luther-s-pathography-and-its-ethical-implications
#3
Birgit Braun, Thomas Loew
Introduction In the context of the 500th anniversary of the Reformation, it is time to take a survey of the history of Martin Luther's (1483-1546) pathography and to deduce possible conclusions from it for psychiatric practice. Results In a 1035-page work written in German between 1937 and 1941, the Dane Paul Reiter retrospectively diagnosed Luther as manic-depressive. In 1956, Grossmann was unable to prove persistent synchronicity of depressive mood and reduced motivation in Luther in the key years 1527 and 1528, which led him to conclude that Luther had a cyclothymic personality with a pyknic constitution...
October 2017: Fortschritte der Neurologie-Psychiatrie
https://www.readbyqxmd.com/read/29017067/clinically-relevant-response-and-remission-outcomes-in-cariprazine-treated-patients-with-bipolar-i-disorder
#4
Willie Earley, Suresh Durgam, Kaifeng Lu, Adam Ruth, György Németh, István Laszlovszky, Lakshmi N Yatham
BACKGROUND: Rates of response and remission are measures that endorse the clinical significance of treatment. Cariprazine is FDA approved for the acute treatment of schizophrenia and manic or mixed episodes associated with bipolar I disorder in adults. Post hoc analyses of pooled data from 3 pivotal trials of cariprazine in manic/mixed episodes associated with bipolar I disorder were conducted to investigate the effect of cariprazine on various criteria of response and remission. METHODS: The constituent studies were 3-week randomized, double-blind, placebo-controlled, multicenter, parallel-group phase II/III studies in adult patients (age 18-65 years) with bipolar I disorder (NCT00488618, NCT01058096, NCT01058668)...
September 25, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28983840/does-perfectionism-in-bipolar-disorder-pedigrees-mediate-associations-between-anxiety-stress-and-mood-symptoms
#5
Justine Corry, Melissa Green, Gloria Roberts, Janice M Fullerton, Peter R Schofield, Philip B Mitchell
BACKGROUND: Bipolar disorder (BD) and the anxiety disorders are highly comorbid. The present study sought to examine perfectionism and goal attainment values as potential mechanisms of known associations between anxiety, stress and BD symptomatology. Measures of perfectionism and goal attainment values were administered to 269 members of BD pedigrees, alongside measures of anxiety and stress, and BD mood symptoms. Regression analyses were used to determine whether perfectionism and goal attainment values were related to depressive and (hypo)manic symptoms; planned mediation models were then used to test the potential for perfectionism to mediate associations between anxiety/stress and BD symptoms...
October 6, 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/28976944/the-new-news-about-lithium-an-underutilized-treatment-in-the-united-states
#6
Robert M Post
Lithium use for the treatment of mood disorders remains quite low, particularly in the United States compared to some European countries. Mogens Schou pioneered the study of lithium for prophylaxis of the recurrent mood disorder and encouraged its greater use. In an effort to further address the appropriate role of this drug, the multiple assets of lithium beyond its well-know anti-manic effect are reviewed, and a brief summary of its side effects is outlined. It appears that lithium has positive effects in depression and suicide prevention, cognition, and reducing the incidence of dementia...
October 4, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28976215/mania-following-antidepressant-discontinuation-in-depression-two-case-reports
#7
Cecilia Sze Nga Kwok, Leslie Eng Choon Lim
OBJECTIVE: Antidepressant-induced mania and an antidepressant discontinuation syndrome are well documented, whereas mania occurring after antidepressant cessation has been infrequently reported. METHOD: We describe antidepressant discontinuation-related mania in two Chinese patients, as well as a review of the literature on this phenomenon in unipolar depression. RESULTS: A 72-year-old man and a 65-year-old woman had late-onset depression with vascular risk factors, but no personal or family history of mood disorders...
September 1, 2017: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/28969438/adjunctive-bright-light-therapy-for-bipolar-depression-a-randomized-double-blind-placebo-controlled-trial
#8
Dorothy K Sit, James McGowan, Christopher Wiltrout, Rasim Somer Diler, John Jesse Dills, James Luther, Amy Yang, Jody D Ciolino, Howard Seltman, Stephen R Wisniewski, Michael Terman, Katherine L Wisner
OBJECTIVE: Patients with bipolar disorder have recurrent major depression, residual mood symptoms, and limited treatment options. Building on promising pilot data, the authors conducted a 6-week randomized double-blind placebo-controlled trial to investigate the efficacy of adjunctive bright light therapy at midday for bipolar depression. The aims were to determine remission rate, depression symptom level, and rate of mood polarity switch, as well as to explore sleep quality. METHOD: The study enrolled depressed adults with bipolar I or II disorder who were receiving stable dosages of antimanic medication (excluding patients with hypomania or mania, mixed symptoms, or rapid cycling)...
October 3, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28946761/randomized-double-blind-placebo-controlled-trial-of-asenapine-maintenance-therapy-in-adults-with-an-acute-manic-or-mixed-episode-associated-with-bipolar-i-disorder
#9
Armin Szegedi, Suresh Durgam, Mary Mackle, Sung Yun Yu, Xiao Wu, Maju Mathews, Ronald P Landbloom
OBJECTIVE: The authors determined the efficacy and safety of asenapine in preventing recurrence of any mood episode in adults with bipolar I disorder. METHOD: Adults with an acute manic or mixed episode per DSM-IV-TR criteria were enrolled in this randomized, placebo-controlled trial consisting of an initial 12- to 16-week open-label period and a 26-week double-blind randomized withdrawal period. The target asenapine dosage was 10 mg b.i.d. in the open-label period but could be titrated down to 5 mg b...
September 26, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28944987/the-international-society-for-bipolar-disorders-task-force-report-on-pediatric-bipolar-disorder-knowledge-to-date-and-directions-for-future-research
#10
REVIEW
Benjamin I Goldstein, Boris Birmaher, Gabrielle A Carlson, Melissa P DelBello, Robert L Findling, Mary Fristad, Robert A Kowatch, David J Miklowitz, Fabiano G Nery, Guillermo Perez-Algorta, Anna Van Meter, Cristian P Zeni, Christoph U Correll, Hyo-Won Kim, Janet Wozniak, Kiki D Chang, Manon Hillegers, Eric A Youngstrom
OBJECTIVES: Over the past two decades, there has been tremendous growth in research regarding bipolar disorder (BD) among children and adolescents (ie, pediatric BD [PBD]). The primary purpose of this article is to distill the extant literature, dispel myths or exaggerated assertions in the field, and disseminate clinically relevant findings. METHODS: An international group of experts completed a selective review of the literature, emphasizing areas of consensus, identifying limitations and gaps in the literature, and highlighting future directions to mitigate these gaps...
September 25, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28922738/mixed-symptoms-in-major-depressive-and-bipolar-disorders-a-systematic-review
#11
REVIEW
Gustavo H Vázquez, María Lolich, Casimiro Cabrera, Ruzica Jokic, Dusan Kolar, Leonardo Tondo, Ross J Baldessarini
BACKGROUND: The DSM-5 mixed features specifier for mood disorders encourages renewed interest in mixed states and led us to pool research findings regarding prevalence of mixed features in episodes of major depressive (MDD) and bipolar disorders (BD). METHODS: We systematically searched to July 2017 for reports on mixed symptoms in depressive episodes of MDD and in depression and mania or hypomania in types I and II BD. For primary mood-states and diagnostic groups we compared rates of the presence of mixed symptoms: as defined by DSM-5 (≥3 features opposite to the dominant mood-polarity but not overlapping those of the primary disorder) or as having any ≥3 features of opposite polarity...
January 1, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28918859/a-preliminary-study-of-bipolar-disorder-type-i-by-mass-spectrometry-based-serum-lipidomics
#12
Henrique C Ribeiro, Aline Klassen, Mariana Pedrini, Michelle S Carvalho, Lucas B Rizzo, Mariane N Noto, Maiara Zeni-Graiff, Sumit Sethi, Francisco A H Fonseca, Ljubica Tasic, Mirian A F Hayashi, Quirino Cordeiro, Elisa Brietzke, Alessandra Sussulini
The present study aimed at investigating possible alterations in the serum lipid profile of euthymic patients with bipolar disorder type I (BD) compared to healthy controls (HC). Thirty-five individuals from both genders were recruited, with 14 diagnosed and treated as BD patients (BD group) and 21 healthy subjects (HC group). Clinical assessment was based on the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I), Young Mania Rating Scale (YMRS), and 17-items of Hamilton Depression Rating Scale (HDRS-17) data, which were used to confirm diagnosis, to verify psychiatric comorbidities, and to estimate the severity of manic and depressive symptoms...
August 21, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28918761/quality-of-life-in-bipolar-disorder-towards-a-dynamic-understanding
#13
E Morton, G Murray, E E Michalak, R W Lam, S Beaulieu, V Sharma, P Cervantes, S V Parikh, L N Yatham
BACKGROUND: Although quality of life (QoL) is receiving increasing attention in bipolar disorder (BD) research and practice, little is known about its naturalistic trajectory. The dual aims of this study were to prospectively investigate: (a) the trajectory of QoL under guideline-driven treatment and (b) the dynamic relationship between mood symptoms and QoL. METHODS: In total, 362 patients with BD receiving guideline-driven treatment were prospectively followed at 3-month intervals for up to 5 years...
September 18, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28918419/-about-the-association-between-antipsychotic-medication-and-cardiovascular-morbidity-epidemiology-and-possible-background-mechanisms
#14
Gabor Gaszner, Gabor Barna, Peter Dome
The history of antipsychotics began with the discovery of chlorpromazine in the 1950s. Since then this group of medications has become one of the most important element of the armamentarium of psychopharmacology. While initially these pharmacons were used in the treatment of psychotic states (including psychotic mania) in the last approximately 10-15 years new indications - such as treatment of depressive, manic and mixed states and also mood-stabilization in bipolar disorder and also the treatment of major depressive disorder - for several second-generation antipsychotic (SGA) agents have been introduced...
June 2017: Neuropsychopharmacologia Hungarica
https://www.readbyqxmd.com/read/28918417/-clinical-features-of-psychotic-and-non-psychotic-bipolar-patients
#15
Zsuzsanna Belteczki, Zoltan Rihmer, Julia Ujvari
BACKGROUND: Psychotic symptoms are common in the case of manic, depressive and mixed episodes of bipolar disorder; however, the assessment of delusions and hallucinations is frequently improper, thus the patients presenting also psychotic symptoms are treated based on their diagnosis of schizophrenia, schizoaffective disorder or paranoia. Psychotic symptoms in bipolar disorder result less favourable outcomes and course of illness. METHODS: 365 patients (106 males, 259 females) were hospitalized in or institution from January 1st 2015 to September 30th 2016, who were diagnosed with bipolar disorder according to the ICD-10 criteria...
June 2017: Neuropsychopharmacologia Hungarica
https://www.readbyqxmd.com/read/28911851/cortisol-awakening-response-in-patients-with-bipolar-disorder-during-acute-episodes-and-partial-remission-a-pilot-study
#16
Ming-Chyi Huang, Shan-Chi Chuang, Mei-Chih Meg Tseng, Yi-Ling Chien, Shih-Cheng Liao, Hsi-Chung Chen, Po-Hsiu Kuo
This exploratory study examined the cortisol awakening response (CAR) in patients with bipolar disorder (BPD) at acute phases and partial remission of manic or depressive episodes. Saliva samples of twenty-seven BPD inpatients and 25 healthy controls were collected to determine the CAR patterns, and 12 patients were sampled again at partial remission. BPD patients exhibited a non-enhanced CAR pattern. Lower cortisol expression and a blunted CAR distinguished bipolar-depressive patients from the controls. The intra-individual follow-up for both patient groups revealed a non-significant improvement in CAR patterns, indicating a trend of a normalized CAR after partial remission for BPD patients...
September 1, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28904603/mindfulness-based-treatment-for-bipolar-disorder-a-systematic-review-of-the-literature
#17
REVIEW
Sanja Bojic, Rodrigo Becerra
Despite the increasing number of studies examining the effects of mindfulness interventions on symptoms associated with Bipolar Disorder (BD), the effectiveness of this type of interventions remains unclear. The aim of the present systematic review was to (i) critically review all available evidence on Mindfulness Based Cognitive Therapy (MBCT) as a form of intervention for BD; (ii) discuss clinical implications of MBCT in treating patients with BD; and (iii) provide a direction for future research. The review presents findings from 13 studies (N = 429) that fulfilled the following selection criteria: (i) included BD patients; (ii) presented results separately for BD patients and control groups (where a control group was available); (iii) implemented MBCT intervention; (iv) were published in English; (v) were published in a peer reviewed journal; and (vi) reported results for adult participants...
August 2017: Europe's journal of psychology
https://www.readbyqxmd.com/read/28888714/the-diagnosis-and-management-of-bipolar-i-and-ii-disorders-clinical-practice-update
#18
REVIEW
William V Bobo
Bipolar disorders, including bipolar I disorder (BP-I) and bipolar II disorder (BP-II), are common, potentially disabling, and, in some cases, life-threatening conditions. Bipolar disorders are characterized by alternating episodes of mania or hypomania and depression, or mixtures of manic and depressive features. Bipolar disorders present many diagnostic and therapeutic challenges for busy clinicians. Adequate management of bipolar disorders requires pharmacotherapy and psychosocial interventions targeted to the specific phases of illness...
October 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/28883733/fan-the-flame-trazodone-induced-mania-in-a-unipolar-depressed-patient-with-stable-sertraline-treatment
#19
Jianbo Hu, Jianbo Lai, Hanzhi Zheng, Shaohua Hu, Yi Xu
Depressed patients often complain of sleep disturbance. Routine antidepressive strategies sometimes fail to deal with this intractable issue. Indeed, the supplementation of sleep promoting antidepressants (eg, trazodone, mirtazapine, and agomelatine) is prevalent in clinical practice. However, the combination of different antidepressants may increase the affective lability. Herein, we document a patient with unipolar depression who was compliant with sertraline treatment and who dramatically switched to mania after adding trazodone as a sleeping aid...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28882405/efficacy-of-quetiapine-xr-vs-placebo-as-concomitant-treatment-to-mood-stabilizers-in-the-control-of-subthreshold-symptoms-of-bipolar-disorder-results-from-a-pilot-randomized-controlled-trial
#20
Marina Garriga, Eva Solé, Ana González-Pinto, Gabriel Selva-Vera, Belén Arranz, Benedikt L Amann, Jerónimo Saiz-Ruiz, Josefina Pérez-Blanco, Eduard Vieta
Patients with bipolar disorder (BD) do not always achieve full remission between episodes. Subthreshold symptoms (depressive, manic or mixed) represent a major cause of relapse and disability in these patients. Immediate release (IR) and extended release (XR) formulations of quetiapine are both indicated for short and long-term treatment of BD. The aim of this study was to evaluate the efficacy of quetiapine XR vs placebo in subthreshold symptomatology when added to previous mood stabilizer treatment. A pilot phase IIIB, multicentre, prospective, placebo controlled, randomized, double blinded study of 12 weeks follow-up was performed (NCT01197846)...
September 4, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
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