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https://www.readbyqxmd.com/read/28102561/stressful-life-events-and-catechol-o-methyl-transferase-comt-gene-in-bipolar-disorder
#1
Georgina M Hosang, Helen L Fisher, Sarah Cohen-Woods, Peter McGuffin, Anne E Farmer
BACKGROUND: A small body of research suggests that gene-environment interactions play an important role in the development of bipolar disorder. The aim of the present study is to contribute to this work by exploring the relationship between stressful life events and the catechol-O-methyl-transferase (COMT) Val(158) Met polymorphism in bipolar disorder. METHODS: Four hundred eighty-two bipolar cases and 205 psychiatrically healthy controls completed the List of Threatening Experiences Questionnaire...
January 19, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28098427/emergence-of-mania-in-two-middle-aged-patients-with-a-history-of-unipolar-treatment-refractory-depression-receiving-vagus-nerve-stimulation
#2
Naji C Salloum, Marie C Walker, Sunil Gangwani, Charles R Conway
OBJECTIVES: We report on two patients who experienced emergence of full manic symptoms while receiving vagal nerve stimulation (VNS). METHODS: Two patients, both with a well-documented and verified history of longstanding unipolar depression, were initiated on VNS for treatment of their severe major depressive episodes. RESULTS: The two patients had emergence of full manic symptoms after 8 and 9 months of VNS, respectively. Manic symptoms were adequately managed with standard treatments (mood stabilizer and electroconvulsive therapy) and VNS was continued in the two subjects for up to 5 years without any further occurrences of manic/hypomanic episodes...
January 18, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28096676/aripiprazole-augmentation-in-managing-comorbid-obsessive-compulsive-disorder-and-bipolar-disorder-a-case-with-suicidal-attempts
#3
Jianbo Lai, Qiaoqiao Lu, Peng Zhang, Tingting Xu, Yi Xu, Shaohua Hu
Comorbid obsessive-compulsive disorder (OCD) and bipolar disorder (BD) have long been an intractable problem in clinical practice. The increased risk of manic/hypomanic switch hinders the use of antidepressants for managing coexisting OCD symptoms in BD patients. We herein present a case of a patient with BD-OCD comorbidity, who was successfully treated with mood stabilizers and aripiprazole augmentation. The young female patient reported recurrent depressive episodes and aggravating compulsive behaviors before hospitalization...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28094461/comparison-of-the-32-item-hypomania-checklist-hcl-32-the-33-item-hypomania-checklist-hcl-33-and-the-mood-disorders-questionnaire-mdq-for-bipolar-disorder
#4
Yuan Feng, Yuan-Yuan Wang, Wei Huang, Gabor S Ungvari, Chee H Ng, Gang Wang, Zhen Yuan, Yu-Tao Xiang
AIM: Bipolar disorder (BD) is frequently misdiagnosed as major depression and hence reliable and culturally appropriate screening tools are needed. This study compared the 32-item Hypomania Checklist (HCL-32), the 33-item Hypomania Checklist (HCL-33), and the Mood Disorders Questionnaire (MDQ) for BD. METHODS: Altogether, 350 depressed patients were included. The HCL-32, the HCL-33 and the MDQ were completed by patients to identify manic and/or hypomanic symptoms...
January 17, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28079488/association-analysis-of-ank3-variants-with-bipolar-disorder-in-the-korean-population
#5
Chul-Hyun Cho, Soojin Kim, Dongho Geum, Heon-Jeong Lee
BACKGROUND: Bipolar disorder (BD) is a major psychiatric disorder characterized by alternating mood episodes, including major depressive, hypomanic, and manic episodes. Previous genetic studies of BD have reported several genes as potentially associated with BD. The ANK3 gene has been identified as a possible BD susceptibility gene in genome-wide association analyses. AIMS: The goal of the present study was to evaluate the association of ANK3 variants with BD in the Korean population...
January 12, 2017: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/28077190/measures-of-the-dsm-5-mixed-features-specifier-of-major-depressive-disorder
#6
Mark Zimmerman
During the past two decades, a number of studies have found that depressed patients frequently have manic symptoms intermixed with depressive symptoms. While the frequency of mixed syndromes are more common in bipolar than in unipolar depressives, mixed states are also common in patients with major depressive disorder. The admixture of symptoms may be evident when depressed patients present for treatment, or they may emerge during ongoing treatment. In some patients, treatment with antidepressant medication might precipitate the emergence of mixed states...
January 12, 2017: CNS Spectrums
https://www.readbyqxmd.com/read/28072644/use-of-an-analog-scale-in-the-treatment-of-patients-with-bipolar-disorder-to-optimize-assessment-and-clinical-outcome
#7
Sheldon H Preskorn
This column explains how a clinician can use an analog scale for patients with bipolar disorder: (1) to elucidate the course of the illness in a specific patient and (2) to assess response to treatment. This scale complements other standardized rating scales, such as the Young Mania Rating Scale, because its anchors are tailored to each specific patient in terms of the worst depressive or hypomanic/manic episode (ie, a -10 or +10, respectively) the person has ever experienced. The scale also allows clinicians to track how the individual patient's episodes have responded to treatment in the past, including whether the patient ever has achieved a full remission (ie, score of 0) following the initial onset of the disorder...
January 2017: Journal of Psychiatric Practice
https://www.readbyqxmd.com/read/28068464/clinical-outcomes-in-children-and-adolescents-with-bipolar-disorder-and-substance-use-disorder-comorbidity
#8
Taiane de Azevedo Cardoso, Karen Jansen, Cristian Patrick Zeni, João Quevedo, Giovana Zunta-Soares, Jair C Soares
OBJECTIVE: To assess the global functioning and clinical outcomes of children and adolescents with bipolar disorder, children and adolescents with bipolar disorder and substance use disorder (SUD) comorbidity and healthy controls. METHODS: This study had a cross-sectional design. Participants were children and adolescents aged between 6 and 17 years, and data were collected between 2003 and 2015. Psychiatric diagnosis was established according to DSM-IV criteria using the Kiddie-SADS-Present and Lifetime Version or the Mini-International Neuropsychiatric Interview for Children and Adolescents...
January 3, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28066002/management-of-obsessive-compulsive-disorder-comorbid-with-bipolar-disorder
#9
REVIEW
Firoz Kazhungil, E Mohandas
Obsessive-compulsive disorder (OCD) is one of the most common comorbidities in bipolar disorder (BD). Clinicians often get perplexed in making treatment decisions when encountering comorbid OCD and BD as treatment of OCD by pharmacotherapy may induce or exacerbate mood instability and psychotherapeutic approaches for OCD may not be feasible in acute manic or depressive state of BD. In this study, we reviewed literature, whether existing guideline-based treatments of BD may be effective in OCD and whether newer agents will be of use for treating this comorbidity...
July 2016: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/28063385/the-effect-of-premorbid-intelligence-on-neurocognitive-and-psychosocial-functioning-in-bipolar-disorder
#10
Diego J Martino, Marina P Valerio, Alejandro G Szmulewicz, Sergio A Strejilevich
BACKGROUND: The aim of this study was to assess if premorbid IQ moderates the association between measures of clinical severity and neurocognitive or psychosocial functioning in euthymic patients with bipolar disorder. METHODS: One hundred and nineteen outpatients and forty healthy controls were included. The length of illness, number of previous hypo/manic and depressive episodes, episode density, and history of psychosis assessed clinical severity. Performances in verbal memory, attention, and executive functions, as well as level of psychosocial functioning were used as outcomes...
January 2, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28061921/bipolar-disorder-in-aviation-medicine
#11
Alpo Vuorio, Tanja Laukkala, Pooshan Navathe, Bruce Budowle, Robert Bor, Antti Sajantila
BACKGROUND: One of the most difficult challenges in aviation medicine is to diagnose, as early as possible, pilots with psychiatric disorders that may impair pilot performance and increase the risk of incidents and accidents. This diagnosis applies particularly to bipolar disorder (BD), where return to flying duty is not an option in the majority of cases. BD is a long-term mental disorder presenting remittent depressive, hypomanic, manic, or mixed episodes between low symptomatic or asymptomatic intermediate periods...
January 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28031070/mixed-features-in-bipolar-disorder
#12
Eva Solé, Marina Garriga, Marc Valentí, Eduard Vieta
Mixed affective states, defined as the coexistence of depressive and manic symptoms, are complex presentations of manic-depressive illness that represent a challenge for clinicians at the levels of diagnosis, classification, and pharmacological treatment. The evidence shows that patients with bipolar disorder who have manic/hypomanic or depressive episodes with mixed features tend to have a more severe form of bipolar disorder along with a worse course of illness and higher rates of comorbid conditions than those with non-mixed presentations...
December 29, 2016: CNS Spectrums
https://www.readbyqxmd.com/read/28008318/alterations-in-cerebrospinal-fluid-in-patients-with-bipolar-syndromes
#13
Dominique Endres, Rick Dersch, Tilman Hottenrott, Evgeniy Perlov, Simon Maier, Dietrich van Calker, Benedikt Hochstuhl, Nils Venhoff, Oliver Stich, Ludger Tebartz van Elst
Bipolar disorder (BD) is a severe and lifelong condition. Primary endogenic polygenetic forms are common. Secondary organic forms have received increasing interest recently due to the detection of immunological encephalopathies that mimic various psychiatric syndromes, including BD. However, only limited data about routine findings of cerebrospinal fluid (CSF) analyses in BD are available. Therefore, we investigated the frequency of alterations in the CSF in patients with BD and the association with autoantibodies, cerebral magnetic resonance imaging, and electroencephalography findings...
2016: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28006664/the-high-burden-of-traumatic-brain-injury-and-comorbidities-amongst-homeless-adults-with-mental-illness
#14
Jane Topolovec-Vranic, Andree Schuler, Agnes Gozdzik, Julian Somers, Paul-Émile Bourque, C James Frankish, Jalila Jbilou, Sarah Pakzad, Luis Ivan Palma Lazgare, Stephen W Hwang
OBJECTIVE: characterize the prevalence of self-reported head injury with loss of consciousness (LOC) and associated demographic, clinical and service use factors in a sample of homeless adults with mental illness. METHOD: Participants in the At Home/Chez Soi study were interviewed at the time of study enrollment regarding their history of head injuries, mental and physical health diagnoses and justice system and healthcare interactions. Sociodemographic and clinical data were also collected...
December 3, 2016: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28004626/treating-mixed-mania-hypomania-a-review-and-synthesis-of-the-evidence
#15
Minoru Takeshima
The DSM-5 incorporates a broad concept of mixed states and captured ≥3 nonoverlapping symptoms of the opposite polarity using a "with mixed features" specifier to be applied to manic/hypomanic and major depressive episodes. Pharmacotherapy of mixed states is challenging because of the necessity to treat both manic/hypomanic and depressive symptoms concurrently. High-potency antipsychotics used to treat manic symptoms and antidepressants can potentially deteriorate symptoms of the opposite polarity. This review aimed to provide a synthesis of the current evidence for pharmacotherapy of mixed states with an emphasis on mixed mania/hypomania...
December 22, 2016: CNS Spectrums
https://www.readbyqxmd.com/read/28003938/an-interventional-study-on-the-clinical-usefulness-and-outcomes-of-electroconvulsive-therapy-in-medication-resistant-mental-disorders
#16
Rameshwar S Manhas, Raheel Mushtaq, Shah Faisal Ahmad Tarfarosh, Sheikh Shoib, Mohammad Maqbool Dar, Arshad Hussain, Tabindah Shah, Sahil Shah, Mushbiq Manzoor
BACKGROUND: Resistance to recommended medications has been an issue in dealing with a number of psychiatric ailments, and it is showing up as an ongoing challenge for contemporary mental health experts. Resistant psychiatric disorders not only increase the morbidity of patients suffering from such severe conditions but also intensify the problems of their caretakers. This has vigorously started to cause the costs to increase for healthcare services. Thanks to electroconvulsive therapy (ECT), we now have an effective method that is proving to be a fruitful final course of action in this micro-epidemic of resistant psychiatric diseases...
October 17, 2016: Curēus
https://www.readbyqxmd.com/read/27998326/reward-related-neural-activity-and-structure-predict-future-substance-use-in-dysregulated-youth
#17
M A Bertocci, G Bebko, A Versace, S Iyengar, L Bonar, E E Forbes, J R C Almeida, S B Perlman, C Schirda, M J Travis, M K Gill, V A Diwadkar, J L Sunshine, S K Holland, R A Kowatch, B Birmaher, D A Axelson, T W Frazier, L E Arnold, M A Fristad, E A Youngstrom, S M Horwitz, R L Findling, M L Phillips
BACKGROUND: Identifying youth who may engage in future substance use could facilitate early identification of substance use disorder vulnerability. We aimed to identify biomarkers that predicted future substance use in psychiatrically un-well youth. METHOD: LASSO regression for variable selection was used to predict substance use 24.3 months after neuroimaging assessment in 73 behaviorally and emotionally dysregulated youth aged 13.9 (s.d. = 2.0) years, 30 female, from three clinical sites in the Longitudinal Assessment of Manic Symptoms (LAMS) study...
December 21, 2016: Psychological Medicine
https://www.readbyqxmd.com/read/27997288/associations-of-perceived-parental-psychopathology-with-mental-health-burden-and-lifetime-drug-use-in-gay-bisexual-and-other-ymsm-the-p18-cohort-study
#18
Perry N Halkitis, Marybec Griffin-Tomas, Michael D Levy, Richard E Greene, Farzana Kapadia
Parental mental health may be a critical component in understanding the overlapping health burdens of mental health symptomatology and drug use in young men who have sex with men (YMSM), yet studies of YMSM have not fully examined these associations. To understand these relationships, data drawn from a study of gay, bisexual, and other YMSM were used examine associations between perceived parental psychopathology and the mental health symptomatology and drug use of YMSM. Findings suggest that YMSM reporting at least one parent with perceived depression, manic depression, schizophrenia, or antisocial behavior anytime during their childhoods were more likely to report higher levels of both depressive symptomatology and post-traumatic stress disorder (PTSD) than those reporting no perception of any of these psychopathologies in their parents...
December 20, 2016: Journal of Homosexuality
https://www.readbyqxmd.com/read/27992834/modality-shift-effect-in-psychiatric-disorders%C3%A2-%C3%A2-a-new-look-at-an-old-paradigm
#19
P J Krag, R W Licht, R E Nielsen
BACKGROUND: There is a long tradition of reaction time studies in experimental psychopathology. Even though a diminishing interest in this paradigm has been seen over the last years, it is in line with more recent biological approaches to examine psychiatric disorders cross-diagnostically. METHODS: Patients (n=95) with a positive subtype of schizophrenia (n=22), a negative subtype of schizophrenia (n=18), a full major depressive episode (n=19), a full manic episode (n=16), or a mood disorder in remission (n=20) and subjects with no known psychiatric disorder (n=30), respectively, participated in a computer-based reaction time test consisting of four trials with 55 short visual and auditory stimuli presented in a random sequence...
December 16, 2016: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/27987053/protection-against-hormone-mediated-mood-symptoms
#20
Leah C Susser, Alison D Hermann
We present the case of a woman with bipolar I disorder with severe premenstrual mood instability, confusion, and psychosis resembling the clinical features of postpartum psychosis when estrogen levels are expected to be low, and hypomania when estrogen levels are expected to be elevated. While depressive symptoms across the menstrual cycle have been extensively documented in the literature, there is little information regarding manic and hypomanic symptoms. In addition, we describe the successful treatment of her menstrual-cycle related symptoms...
December 16, 2016: Archives of Women's Mental Health
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