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https://www.readbyqxmd.com/read/29457216/n-acetylcysteine-for-major-mental-disorders-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#1
W Zheng, Q-E Zhang, D-B Cai, X-H Yang, Y Qiu, G S Ungvari, C H Ng, M Berk, Y-P Ning, Y-T Xiang
OBJECTIVE: This systematic review and meta-analysis of randomized controlled trials (RCTs) examined the efficacy and safety of adjunctive N-acetylcysteine (NAC), an antioxidant drug, in treating major depressive disorder (MDD), bipolar disorder, and schizophrenia. METHODS: The PubMed, Cochrane Library, PsycINFO, CNKI, CBM, and WanFang databases were independently searched and screened by two researchers. Standardized mean differences (SMDs), risk ratios, and their 95% confidence intervals (CIs) were computed...
February 18, 2018: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/29457195/the-association-between-mood-state-and-chronobiological-characteristics-in-bipolar-i-disorder-a-naturalistic-variable-cluster-analysis-based-study
#2
Robert Gonzalez, Trisha Suppes, Jamie Zeitzer, Colleen McClung, Carol Tamminga, Mauricio Tohen, Angelica Forero, Alok Dwivedi, Andres Alvarado
BACKGROUND: Multiple types of chronobiological disturbances have been reported in bipolar disorder, including characteristics associated with general activity levels, sleep, and rhythmicity. Previous studies have focused on examining the individual relationships between affective state and chronobiological characteristics. The aim of this study was to conduct a variable cluster analysis in order to ascertain how mood states are associated with chronobiological traits in bipolar I disorder (BDI)...
February 19, 2018: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/29451588/religiosity-depression-and-quality-of-life-in-bipolar-disorder-a-two-year-prospective-study
#3
André Stroppa, Fernando A Colugnati, Harold G Koenig, Alexander Moreira-Almeida
OBJECTIVE: Few quantitative studies have examined the effect of religious involvement on the course of bipolar disorder (BD). We investigated the effects of religious activity and coping behaviors on the course of depression, mania, and quality of life (QoL) in patients with BD. METHODS: Two-year longitudinal study of 168 outpatients with BD. Linear regression was used to examine associations between religious predictors and outcome variables (manic symptoms, depression, QoL), controlling for sociodemographic variables...
February 15, 2018: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/29449055/adjunctive-antidepressants-in-bipolar-depression-a-cohort-study-of-six-and-twelve-months-rehospitalization-rates
#4
Yahav Shvartzman, Amir Krivoy, Avi Valevski, Shay Gur, Abraham Weizman, Eldar Hochman
Although antidepressants (ADs) are widely used in bipolar depression, there is weak evidence for their effectiveness and safety in this condition. Furthermore, there is a paucity of studies on the risk-benefit ratio of AD maintenance treatment in bipolar disorder (BD). We compared rehospitalization rates of patients with BD-I depressive episode who were discharged with mood stabilizers (MSs) and/or atypical antipsychotics (AAPs) with or without adjunctive AD. Ninety-eight patients with BD-I who were hospitalized with a depressive episode between 2005 and 2013 were retrospectively followed for 6-months and 1-year rehospitalization rates, as well as time to rehospitalization, according to treatment at discharge: MSs and/or AAPs with or without AD...
February 12, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29441650/incidence-prevalence-and-clinical-correlates-of-antidepressant-emergent-mania-in-bipolar-depression-a-systematic-review-and-meta-analysis
#5
REVIEW
Michele Fornaro, Annalisa Anastasia, Stefano Novello, Andrea Fusco, Marco Solmi, Francesco Monaco, Nicola Veronese, Domenico De Berardis, Andrea de Bartolomeis
BACKGROUND: Treatment-emergent mania (TEM) represents a common phenomenon inconsistently reported across primary studies, warranting further assessment. METHODS: A systematic review and meta-analysis following the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) and Meta-Analysis of Observational Studies in Epidemiology (MOOSE) guidelines were conducted. Major electronic databases were searched from inception to May 2017 to assess the incidence and prevalence rates and clinical features associated with manic switch among bipolar depressed patients receiving antidepressants, using meta-regression and subgroup analysis...
February 14, 2018: Bipolar Disorders
https://www.readbyqxmd.com/read/29433074/the-relationship-between-inflammatory-state-and-quantity-of-affective-episodes-in-bipolar-disorder
#6
Robert Queissner, René Pilz, Nina Dalkner, Armin Birner, Susanne A Bengesser, Martina Platzer, Frederike T Fellendorf, Nora Kainzbauer, Simone Herzog-Eberhard, Carlo Hamm, Bernd Reininghaus, Sieglinde Zelzer, Harald Mangge, Rodrigo B Mansur, Roger S McIntyre, Hans-Peter Kapfhammer, Eva Z Reininghaus
OBJECTIVES: Immunological/inflammatory processes have been proposed to play an important role in the pathophysiology of mood disorders, including bipolar disorder (BD). The present study aimed to examine the influence of immune activation, measured on the basis of inflammatory markers, on the course of illness, proxied by the number of affective episodes, in patients with BD. METHODS: We investigated the relationship between high-sensitive CRP (hsCRP) and Interleukin 6 (IL-6), two inflammatory markers and characteristics of course of illness (e...
February 3, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29426253/symptom-profile-of-psychiatric-patients-with-psychosis-or-psychotic-mood-disorder-in-prison
#7
J van Beek, P J Vuijk, J M Harte, E J A Scherder
There is evidence that psychiatric patients with psychotic or manic disorders who are incarcerated suffer from the same symptoms as psychiatric patients who are treated in the community. There are also indications that their symptoms might be more severe. The aim of this study was to examine the severity of psychotic and manic symptoms, as well as to collect information about the emotional functioning of patients admitted to a prison psychiatric ward. Incarcerated patients with a diagnosis of psychotic or a manic disorder were examined with the Brief Psychiatric Rating Scale-Expanded (BPRS-E)...
February 1, 2018: International Journal of Offender Therapy and Comparative Criminology
https://www.readbyqxmd.com/read/29407766/dopamine-d3-receptor-blockade-rescues-hyper-dopamine-activity-induced-deficit-in-novel-object-recognition-memory
#8
Pi-Kai Chang, Lung Yu, Jin-Chung Chen
Patients afflicted with bipolar disorder demonstrate significant impairments in recognition and episodic memory during acute depressive and manic episodes. These impairments and the related pathophysiology may result from over-activation of the brain dopamine (DA) system. In order to model overactive DA transmission in a well-established novel object recognition (NOR) memory test, we used DA transporter knockdown (DAT-KD) mice, which exhibit reduced DAT expression and display hyper-dopaminergic phenotypes. DAT-KD mice exhibited impaired NOR memory compared to wild-type (WT) mice...
February 1, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29407727/dna-redox-modulations-and-global-dna-methylation-in-bipolar-disorder-effects-of-sex-smoking-and-illness-state
#9
Deniz Ceylan, Gustavo Scola, Zeliha Tunca, Cameron Isaacs-Trepanier, Güneş Can, Ana C Andreazza, L Trevor Young, Ayşegül Özerdem
DNA redox modulations and methylation have been associated with bipolar disorder (BD) pathophysiology. We aimed to investigate DNA redox modulation and global DNA methylation and demethylation levels in patients with BD during euthymia, mania or depression in comparison to non-psychiatric controls. The roles of sex and smoking as susceptibility factors for DNA redox modulations and global DNA methylation and demethylation were also explored. Levels of 5-methylcytosine (5-mC), 5-hydroxymethylcytosine (5-hmC) and 8-hydroxy-2'-deoxyguanosine (8-OHdG) were assessed in DNA samples of 75 patients with DSM-IV BD type I (37 euthymic, 18 manic, 20 depressive) in comparison to 60 non-psychiatric controls...
December 27, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29407357/measuring-racing-thoughts-in-healthy-individuals-the-racing-and-crowded-thoughts-questionnaire-rctq
#10
Luisa Weiner, Sébastien Weibel, Wagner de Sousa Gurgel, Ineke Keizer, Marianne Gex-Fabry, Anne Giersch, Gilles Bertschy
Racing thoughts refer to an acceleration and overproduction of thoughts, which have been associated with manic and mixed episodes. Phenomenology distinguishes 'crowded' from 'racing' thoughts, associated with mixed depression and mania, respectively. Recent data suggest racing thoughts might also be present in healthy individuals with sub-affective traits and symptoms. We investigated this assumption, with a 34-item self-rating scale, the Racing and Crowded Thoughts Questionnaire (RCTQ), and evaluated its reliability, factor structure, and concurrent validity...
January 26, 2018: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/29397672/depression-and-mania-induce-pro-inflammatory-activation-of-macrophages-following-application-of-serum-from-individuals-with-bipolar-disorder
#11
Pamela Ferrari, Mariana Migliorini Parisi, Rafael Colombo, Matheus Becker, Gabriel Fries, Bruna Maria Ascoli, Luiza Paul Géa, Márcia Kauer-Sant Anna, Flávio Kapczinski, Fábio Klamt, Fátima T C R Guma, Adriane Ribeiro Rosa, Florencia M Barbé-Tuana
Objective: Evidence has suggested that immune imbalance is involved with bipolar disorder (BD); however, its precise mechanism is poorly understood. This study investigated whether biochemical changes in the serum from BD patients could modulate the phenotype of cultured macrophages. Methods: Eighteen subjects with BD and five healthy individuals were included in this study. The human monocyte cell line U-937 was activated with phorbol 12-myristate 13-acetate (PMA) and polarization was induced with RPMI-1640 media supplemented with 10% serum from each patient for 24 hours...
February 28, 2018: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29391394/testing-frameworks-for-personalizing-bipolar-disorder
#12
Amy L Cochran, André Schultz, Melvin G McInnis, Daniel B Forger
The hallmark of bipolar disorder is a clinical course of recurrent manic and depressive symptoms of varying severity and duration. Mathematical modeling of bipolar disorder holds the promise of an ability to personalize diagnoses, to predict future mood episodes, to directly compare diverse datasets, and to link basic mechanisms to behavioral data. Several modeling frameworks have been proposed for bipolar disorder, which represent competing hypothesis about the basic framework of the disorder. Here, we test these hypotheses with self-report assessments of mania and depression symptoms from 178 bipolar patients followed prospectively for 4 or more years...
February 2, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29385961/national-estimates-of-recovery-remission-from-serious-mental-illness
#13
Mark S Salzer, Eugene Brusilovskiy, Greg Townley
OBJECTIVE: A broad range of estimates of recovery among previously institutionalized persons has been reported, but no current, community-based national estimate of recovery from serious mental illness exists. This study reports recovery rate results, based on a remission definition, and explores related demographic factors. METHODS: A national, geographically stratified, and random cross-sectional survey conducted from September 2014 to December 2015 resulted in responses from more than 41,000 individuals...
February 1, 2018: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/29374602/reduction-in-endogenous-cardiac-steroids-protects-the-brain-from-oxidative-stress-in-a-mouse-model-of-mania-induced-by-amphetamine
#14
Anastasia Hodes, Tzuri Lifschytz, Haim Rosen, Hagit Cohen-Ben Ami, David Lichtstein
OBJECTIVES: Bipolar disorder (BD) is a severe mental illness characterized by episodes of mania and depression. Numerous studies have implicated the involvement of endogenous cardiac steroids (CS), and their receptor, Na+, K+ -ATPase, in BD. The aim of the present study was to examine the role of brain oxidative stress in the CS-induced behavioral effects in mice. METHODS: Amphetamine (AMPH)-induced hyperactivity, assessed in the open-field test, served as a model for manic-like behavior in mice...
January 25, 2018: Brain Research Bulletin
https://www.readbyqxmd.com/read/29373619/a-brief-history-of-polarity-in-mood-and-its-diagnostic-evolution
#15
Omar Khan, Nagy A Youssef
BACKGROUND: We reviewed the historical development of diagnostic nomenclature and classification systems of mood disorders. METHODS: A literature search in PubMed and Google Scholar was performed using multiple search terms. Also, the criteria and classification of various mood disorders were reviewed and compared across all editions of DSM. We also reviewed several books and the references of the found articles. RESULTS: This review describes the historical development of the concepts and diagnostic nomenclature of mood disorders, including the encompassing of most of the now major depressive disorder under the prior manic-depressive illness...
February 2018: Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists
https://www.readbyqxmd.com/read/29373050/diagnostic-accuracy-of-the-casi-4r-psychosis-subscale-for-children-evaluated-in-pediatric-outpatient-clinics
#16
Sabeen H Rizvi, Stephanie Salcedo, Eric A Youngstrom, Lindsey K Freeman, Kenneth D Gadow, Mary A Fristad, Boris Birmaher, Robert A Kowatch, Sarah M Horwitz, Thomas W Frazier, L Eugene Arnold, H Gerry Taylor, Robert L Findling
Diagnostic accuracy of the Diagnostic and Statistical Manual of Mental Disorders-oriented Child and Adolescent Symptom Inventory (CASI-4R) Psychotic Symptoms scale was tested using receiver operating characteristic analyses to identify clinically significant psychotic symptoms. Participants were new outpatients (N = 700), ages 6.0 to 12.9 years (M = 9.7, SD = 1.8) at 9 child outpatient mental health clinics, who participated in the Longitudinal Assessment of Manic Symptoms (LAMS) Study baseline assessment...
January 26, 2018: Journal of Clinical Child and Adolescent Psychology
https://www.readbyqxmd.com/read/29366645/serum-nerve-growth-factor-beta-brain-and-glial-derived-neurotrophic-factor-levels-and-psychopathology-in-unmedicated-patients-with-schizophrenia
#17
Che-Sheng Chu, Chin-Liang Chu, Chih-Ching Wu, Ti Lu
BACKGROUND: There is accumulating evidence that neurotrophic factors may be involved in the pathophysiology of patients with schizophrenia. This study aimed to explore the relationship between serum nerve growth factor beta (NGF-beta), brain-derived neurotrophic factor (BDNF), and glial-derived neurotrophic factor (GDNF) levels and psychopathology in unmedicated patients with schizophrenia. METHODS: Serum NGF-beta, BDNF, and GDNF levels were determined using enzyme-linked-immunosorbent assay (ELISA) in the serum of 30 unmedicated patients with schizophrenia...
January 20, 2018: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29361880/an-overview-of-pharmacotherapy-for-bipolar-i-disorder
#18
Anne Michal Morsel, Manuel Morrens, Bernard Sabbe
Bipolar I disorder (BD I) is complex with a chronic course that significantly impacts a sufferer's quality of life. As of right now, there are many available treatments that aim to rapidly treat manic or depressive episodes and stabilize mood. The purpose of this report is to provide an up-to-date comprehensive review of the available evidence-based trials of pharmacotherapy for the treatment of BD I. Areas covered: This paper reviews randomized active comparator-controlled or placebo-controlled trials evaluating the use of current pharmacotherapy in adults with BD I from phase III to clinical practice...
January 23, 2018: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/29360052/the-impact-of-affective-temperaments-on-clinical-and-functional-outcome-of-bipolar-i-patients-that-initiated-or-changed-pharmacological-treatment-for-mania
#19
G Perugi, D Cesari, G Vannucchi, G Maccariello, M Barbuti, A De Bartolomeis, A Fagiolini, G Maina
BACKGROUND: Affective temperaments have been shown to impact on the clinical manifestations and the course of bipolar disorder. We investigated their influence on clinical features and functional outcome of manic episode. METHOD: In a naturalistic, multicenter, national study, a sample of 194 BD I patients that initated or changed pharmacological treatment for DSM-IV-TR manic episode underwent a comprehensive evaluation including briefTEMPS-M, CTQ, YMRS, MADRS, FAST, and CGI-BP...
January 19, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29356281/episode-forecasting-in-bipolar-disorder-is-energy-better-than-mood
#20
Abigail Ortiz, Kamil Bradler, Arend Hintze
OBJECTIVE: Bipolar disorder is a severe mood disorder characterized by alternating episodes of mania and depression. Several interventions have been developed to decrease high admission rates and high suicides rates associated with the illness, including psychoeducation and early episode detection, with mixed results. More recently, machine learning approaches have been used to aid clinical diagnosis or to detect a particular clinical state; however, contradictory results arise from confusion around which of the several automatically generated data are the most contributory and useful to detect a particular clinical state...
January 22, 2018: Bipolar Disorders
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