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https://www.readbyqxmd.com/read/29653381/swelling-of-fiber-reinforced-soft-tissues-is-affected-by-fiber-orientation-fiber-stiffness-and-lamella-structure
#1
Bo Yang, Grace D O'Connell
Native and engineered fiber-reinforced tissues are composites comprised of stiff collagen fibers embedded within an extrafibrillar matrix that is capable of swelling by absorbing water molecules. Tissue swelling is important for understanding stress distributions between collagen fibers and extrafibrillar matrix, as well as for understanding mechanisms of tissue failure. The swelling behavior of fiber-reinforced tissues in the musculoskeletal system has been largely attributed to the glycosaminoglycan content...
April 3, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29652320/-bronchial-fistula-management-is-the-exit-found
#2
I Ya Motus, A V Bazhenov, A S Tsvirenko, R T Basyrov, P M Kholny, L V Kardapoltsev, P P Pechnikov
AIM: To present treatment of bronchial fistulas by using of occluders. MATERIAL AND METHODS: For the period from March 2015 to October 2016 Atrial Septal Defect (ASD) occluders have been used for bronchial fistulas occlusion (Lepu Medical Technology Co., Ltd.; Lifetech Scientific Co., Ltd.). These are devices designed to close ventricular and atrial septal defects. The procedure was performed in 8 patients with main bronchus fistula occurred after pulmonectomy for tuberculosis in 5 patients and lung cancer in 3 patients...
2018: Khirurgiia
https://www.readbyqxmd.com/read/29652256/exploiting-distant-homologues-for-phasing-through-the-generation-of-compact-fragments-local-fold-refinement-and-partial-solution-combination
#3
Claudia Millán, Massimo Domenico Sammito, Airlie J McCoy, Andrey F Ziem Nascimento, Giovanna Petrillo, Robert D Oeffner, Teresa Domínguez-Gil, Juan A Hermoso, Randy J Read, Isabel Usón
Macromolecular structures can be solved by molecular replacement provided that suitable search models are available. Models from distant homologues may deviate too much from the target structure to succeed, notwithstanding an overall similar fold or even their featuring areas of very close geometry. Successful methods to make the most of such templates usually rely on the degree of conservation to select and improve search models. ARCIMBOLDO_SHREDDER uses fragments derived from distant homologues in a brute-force approach driven by the experimental data, instead of by sequence similarity...
April 1, 2018: Acta Crystallographica. Section D, Structural Biology
https://www.readbyqxmd.com/read/29651634/air-quality-and-passenger-comfort-in-an-air-conditioned-bus-micro-environment
#4
Xiaoxuan Zhu, Li Lei, Xingshen Wang, Yinghui Zhang
In this study, passenger comfort and the air pollution status of the micro-environmental conditions in an air-conditioned bus were investigated through questionnaires, field measurements, and a numerical simulation. As a subjective analysis, passengers' perceptions of indoor environmental quality and comfort levels were determined from questionnaires. As an objective analysis, a numerical simulation was conducted using a discrete phase model to determine the diffusion and distribution of pollutants, including particulate matter with a diameter < 10 μm (PM10 ), which were verified by experimental results...
April 12, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29651108/3d-artificial-round-section-micro-vessels-to-investigate-endothelial-cells-under-physiological-flow-conditions
#5
Riccardo Sfriso, Shengye Zhang, Colette Andrea Bichsel, Oliver Steck, Alain Despont, Olivier Thierry Guenat, Robert Rieben
In the context of xenotransplantation, in ischemia/reperfusion injury as well as in cardiovascular research, the study of the fascinating interplay between endothelial cells (EC) and the plasma cascade systems often requires in vitro models. Blood vessels are hardly reproducible with standard flat-bed culture systems and flow-plate assays are limited in their low surface-to-volume ratio which impedes the study of the anticoagulant properties of the endothelial cells. According to the 3R regulations (reduce, replace and refine animal experimentation) we developed a closed circuit microfluidic in vitro system in which endothelial cells are cultured in 3D round section microchannels and subjected to physiological, pulsatile flow...
April 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29650791/impairments-in-adipose-tissue-microcirculation-in-type-2-diabetes-mellitus-assessed-by-real-time-contrast-enhanced-ultrasound
#6
Donghua Hu, Devika Remash, Ryan D Russell, Timothy Greenaway, Stephen Rattigan, Kathryn A Squibb, Graeme Jones, Dino Premilovac, Stephen M Richards, Michelle A Keske
BACKGROUND: In obesity and type 2 diabetes mellitus (T2D), adipose tissue expansion (because of larger adipocytes) results in reduced microvascular density which is thought to lead to adipocyte hypoxia, inflammation, and reduced nutrient delivery to the adipocyte. Adipose tissue microvascular responses in humans with T2D have not been extensively characterized. Furthermore, it has not been determined whether impaired microvascular responses in human adipose tissue are most closely associated with adiposity, inflammation, or altered metabolism...
April 2018: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29648983/enhancement-of-brain-d-serine-mediates-recovery-of-cognitive-function-after-tbi
#7
Sigal Liraz-Zaltsman, Barbara Slusher, Dana Atrakchi-Baranes, Kinneret Rosenblatt, Yael Friedman Levi, Efrat Leah Kesner, Alcino J Silva, Anat Biegon, Esther Shohami
Cognitive deficits, especially memory loss, are common and devastating neuropsychiatric sequelae of traumatic brain injury (TBI). The deficits may persist for a long time and may be accompanied by increased risk of developing early onset dementia. Past attempts to reverse the neuropsychological effects of brain injury with glutamate-N-methyl-D-aspartate (NMDA) antagonists failed to show any benefits or worsened the outcome, suggesting activation, rather than blockage, of the NMDA receptor (NMDAR) may be useful in the sub-acute period after TBI and stroke...
March 14, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29645352/the-uk-rope-study-efficacy-and-safety-of-prostate-artery-embolisation-for-benign-prostatic-hyperplasia-an-observational-study-and-propensity-matched-comparison-with-transurethral-resection-of-the-prostate
#8
A F Ray, J Powell, M J Speakman, N T Longford, R DasGupta, T Bryant, S Modi, J Dyer, M Harris, G Carolan-Rees, N Hacking
OBJECTIVES: The UK Register of Prostate Embolisation (UK ROPE) study aimed to assess the efficacy and safety of Prostate Artery Embolisation (PAE) for Lower Urinary Tract Symptoms secondary to Benign Prostatic Hyperplasia (LUTS/BPH) patients. The main secondary aim was an indirect comparison with transurethral resection of the prostate (TURP). SUBJECTS/PATIENTS AND METHODS: As a joint initiative between BSIR, BAUS and NICE, this study recruited 305 patients across 17 UK urological / interventional radiology centres: 216 PAE, 89 TURP...
April 12, 2018: BJU International
https://www.readbyqxmd.com/read/29644717/diets-of-reef-dwelling-labrids-choerodon-species-vary-with-body-size-season-and-habitat-influence-of-foraging-ability-specialization-and-opportunism
#9
E Lek, M E Platell, D V Fairclough, N G Hall, I C Potter
Contemporary multivariate statistics were used to test the hypotheses that the dietary compositions of three populations of labrids on the west Australian coast are related to body size and undergo seasonal changes and to elucidate the relative extents and basis for any dietary differences within and between those populations. Gut content analyses determined the dietary compositions of Choerodon rubescens in marine waters of the outer reefs in the World Heritage Area of Shark Bay (26° S; 114° E) and of Choerodon schoenleinii in inner protected reefs of that large embayment...
April 2018: Journal of Fish Biology
https://www.readbyqxmd.com/read/29644221/physiologic-factors-influencing-the-arterial-to-end-tidal-co-2-difference-and-the-alveolar-dead-space-fraction-in-spontaneously-breathing-anesthetised-horses
#10
Martina Mosing, Stephan H Böhm, Anthea Rasis, Giselle Hoosgood, Ulrike Auer, Gerardo Tusman, Regula Bettschart-Wolfensberger, Johannes P Schramel
The arterial to end-tidal CO2 difference (P(a-ET) CO2 ) and alveolar dead space fraction (VDalvfrac  = P(a-ET) CO2 /PaCO2 ), are used to estimate Enghoff's "pulmonary dead space" (V/QEng ), a factor which is also influenced by venous admixture and other pulmonary perfusion abnormalities and thus is not just a measure of dead space as the name suggests. The aim of this experimental study was to evaluate which factors influence these CO2 indices in anesthetized spontaneously breathing horses. Six healthy adult horses were anesthetized in dorsal recumbency breathing spontaneously for 3 h...
2018: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29630104/early-diagnostic-role-of-psa-combined-mir-155-detection-in-prostate-cancer
#11
T Guo, X-X Wang, H Fu, Y-C Tang, B-Q Meng, C-H Chen
OBJECTIVE: As a kind of malignant tumor in the male genitourinary system, prostate cancer exhibits significantly increased occurrence. Prostate-specific antigen (PSA) expression can be seen in the prostate cancer, prostatitis, and other diseases, therefore, lack of diagnostic specificity. The miR-155 expression is abnormally increased in the tumors. Therefore, this study aims to explore the clinical significance of PSA combined miR-155 detection in the early diagnosis of prostate cancer...
March 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29628218/effects-of-sex-hormones-and-age-on-brain-volume-in-post-menopausal-women
#12
Gwang-Won Kim, Kwangsung Park, Gwang-Woo Jeong
BACKGROUND: Investigation of the effect of sex hormones on the brain volume in women provides a unique opportunity to examine menopause-related morphometric alterations. AIM: To evaluate brain morphological alterations in post-menopausal women using voxel-based morphometry and its correlations with sex hormone levels. METHODS: 20 Pre-menopausal women and 20 post-menopausal women underwent structural MRI. OUTCOMES: T1-weighted magnetic resonance data were acquired and serum sex hormones including total estrogen, estriol, estradiol (E2), follicle-stimulating hormone, free testosterone, SHBG, and luteinizing hormone were measured...
April 5, 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29628040/-patterns-of-brain-ageing
#13
Carlos Fernández Viadero, Rosario Verduga Vélez, Dámaso Crespo Santiago
Neuroplasticity lends the brain a strong ability to adapt to changes in the environment that occur during ageing. Animal models have shown alterations in neurotransmission and imbalances in the expression of neural growth factor. Changes at the morphometric level are not constant. Volume loss is related to alterations in neuroplasticity and involvement of the cerebral neuropil. Although there are no conclusive data, physical exercise improves the molecular, biological, functional and behavioural-cognitive changes associated with brain ageing...
June 2017: Revista Española de Geriatría y Gerontología
https://www.readbyqxmd.com/read/29627534/assessment-of-the-effects-of-discontinuous-sources-of-contamination-through-biomarker-analyses-on-caged-mussels
#14
A De Los Ríos, B Echavarri-Erasun, M-H Dévier, K Le Menach, H Budzinski, M Ortiz-Zarragoitia, A Orbea, J A Juanes, M P Cajaraville
The present study analysed potential adverse effects of discontinuous sources of contamination, namely the discharge of a combined sewer overflow (CSO) and of runoff in an urban area, the Bay of Santander (North Iberian Peninsula). Water samples and caged mussels were used to analyse concentrations of contaminants and biological responses. Mussels (Mytilus galloprovincialis) were transplanted to a marina receiving runoff from a petrol station and to a CSO discharge site. Samples were collected in synchrony with heavy rains along 62days...
April 5, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29627154/how-to-close-classic-bladder-exstrophy-are-subspecialty-training-and-technique-important
#15
Brian M Inouye, J Todd Purves, Jonathan C Routh, Mahir Maruf, Daniel Friedlander, John Jayman, John P Gearhart
INTRODUCTION: Successful primary closure is one of the main factors for achieving continence in a classic bladder exstrophy (CBE) patient. Even with contemporary management, patients still have failed primary closures. We sought to understand the role of training, surgical technique, and their impacts on outcomes of CBE closure. MATERIALS AND METHODS: A retrospective cohort study from the largest single-institution database of primary and re-closure CBE patients in the world was performed...
March 29, 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29625480/microvascular-density-is-associated-with-retinal-ganglion-cell-axonal-volume-in-the-laminar-compartments-of-the-human-optic-nerve-head
#16
Min H Kang, Mengchen Suo, Chandrakumar Balaratnasingam, Paula K Yu, William H Morgan, Dao-Yi Yu
Purpose: To quantify associations between microvascular density and retinal ganglion cell (RGC) axonal volume in the laminar compartments of the human optic nerve head (ONH). Methods: Eleven normal human ONHs were evaluated. Antibodies were used to label the vascular endothelium (factor VIII-related antigen/von Willebrand factor antibody) and RGC axons (neurofilament heavy antibody). Three-dimensional analysis of confocal scanning laser microscope images was used to study microvascular density and RGC axonal volume in the prelaminar, anterior lamina cribrosa, posterior lamina cribrosa, and retrolaminar compartments...
March 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29623552/first-in-human-intraoperative-near-infrared-fluorescence-imaging-of-glioblastoma-using-cetuximab-irdye800
#17
Sarah E Miller, Willemieke S Tummers, Nutte Teraphongphom, Nynke S van den Berg, Alifia Hasan, Robert D Ertsey, Seema Nagpal, Lawrence D Recht, Edward D Plowey, Hannes Vogel, Griffith R Harsh, Gerald A Grant, Gordon H Li, Eben L Rosenthal
INTRODUCTION: Maximizing extent of surgical resection with the least morbidity remains critical for survival in glioblastoma patients, and we hypothesize that it can be improved by enhancements in intraoperative tumor detection. In a clinical study, we determined if therapeutic antibodies could be repurposed for intraoperative imaging during resection. METHODS: Fluorescently labeled cetuximab-IRDye800 was systemically administered to three patients 2 days prior to surgery...
April 6, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29619647/assessment-of-cerebral-hemodynamic-parameters-using-pulsatile-versus-non-pulsatile-cerebral-blood-outflow-models
#18
Agnieszka Uryga, Magdalena Kasprowicz, Leanne Calviello, Rolf R Diehl, Katarzyna Kaczmarska, Marek Czosnyka
BACKGROUND: Prior methods evaluating the changes in cerebral arterial blood volume (∆Ca BV) assumed that brain blood transport distal to big cerebral arteries can be approximated with a non-pulsatile flow (CFF) model. In this study, a modified ∆Ca BV calculation that accounts for pulsatile blood flow forward (PFF) from large cerebral arteries to resistive arterioles was investigated. The aim was to assess cerebral hemodynamic indices estimated by both CFF and PFF models while changing arterial blood carbon dioxide concentration (EtCO2 ) in healthy volunteers...
April 4, 2018: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/29618981/influence-of-endurance-training-during-childhood-on-total-hemoglobin-mass
#19
Nicole Prommer, Nadine Wachsmuth, Ina Thieme, Christian Wachsmuth, Erica M Mancera-Soto, Andreas Hohmann, Walter F J Schmidt
Elite endurance athletes are characterized by markedly increased hemoglobin mass (Hbmass). It has been hypothesized that this adaptation may occur as a response to training at a very young age. Therefore, the aim of this study was to monitor changes in Hbmass in children aged 8-14 years following systematic endurance training. In the first study, Hbmass, VO2max, and lean body mass (LBM) were measured in 17 endurance-trained children (13 boys and 4 girls; aged 9.7 ± 1.3 years; training history 1.5±1.8 years; training volume 3...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29618801/respiration-and-the-watershed-of-spinal-csf-flow-in-humans
#20
Steffi Dreha-Kulaczewski, Mareen Konopka, Arun A Joseph, Jost Kollmeier, Klaus-Dietmar Merboldt, Hans-Christoph Ludwig, Jutta Gärtner, Jens Frahm
The dynamics of human CSF in brain and upper spinal canal are regulated by inspiration and connected to the venous system through associated pressure changes. Upward CSF flow into the head during inspiration counterbalances venous flow out of the brain. Here, we investigated CSF motion along the spinal canal by real-time phase-contrast flow MRI at high spatial and temporal resolution. Results reveal a watershed of spinal CSF dynamics which divides flow behavior at about the level of the heart. While forced inspiration prompts upward surge of CSF flow volumes in the entire spinal canal, ensuing expiration leads to pronounced downward CSF flow, but only in the lower canal...
April 4, 2018: Scientific Reports
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