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https://www.readbyqxmd.com/read/28324990/indirect-measurement-of-the-carotid-arterial-pressure-from-vibrocardiographic-signal-calibration-of-the-waveform-and-comparison-with-photoplethysmographic-signal
#1
L Casacanditella, G Cosoli, S Casaccia, E P Tomasini, L Scalise
The detection of arterial Blood Pressure waveform provides important information about the subject health status. Laser Doppler Vibrometry (LDV) is a non-contact technique with high sensitivity able to detect mechanical movements of the arterial wall; several previous studies have shown that LDV is able to characterize cardiac activity. Photoplethysmogram (PPG) quantifies the digital volume artery pulse, which has been demonstrated to be closely related to the pressure signal measured by an arterial tonometer...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28324943/overcoming-spatio-temporal-limitations-using-dynamically-scaled-in-vitro-pc-mri-a-flow-field-comparison-to-true-scale-computer-simulations-of-idealized-stented-and-patient-specific-left-main-bifurcations
#2
Susann Beier, John Ormiston, Mark Webster, John Cater, Stuart Norris, Pau Medrano-Gracia, Alistair Young, Kathleen Gilbert, Brett Cowan
The majority of patients with angina or heart failure have coronary artery disease. Left main bifurcations are particularly susceptible to pathological narrowing. Flow is a major factor of atheroma development, but limitations in imaging technology such as spatio-temporal resolution, signal-to-noise ratio (SNRv), and imaging artefacts prevent in vivo investigations. Computational fluid dynamics (CFD) modelling is a common numerical approach to study flow, but it requires a cautious and rigorous application for meaningful results...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28323828/liquid-handling-lego-robots-and-experiments-for-stem-education-and-research
#3
Lukas C Gerber, Agnes Calasanz-Kaiser, Luke Hyman, Kateryna Voitiuk, Uday Patil, Ingmar H Riedel-Kruse
Liquid-handling robots have many applications for biotechnology and the life sciences, with increasing impact on everyday life. While playful robotics such as Lego Mindstorms significantly support education initiatives in mechatronics and programming, equivalent connections to the life sciences do not currently exist. To close this gap, we developed Lego-based pipetting robots that reliably handle liquid volumes from 1 ml down to the sub-μl range and that operate on standard laboratory plasticware, such as cuvettes and multiwell plates...
March 2017: PLoS Biology
https://www.readbyqxmd.com/read/28323641/metal-artifacts-in-computed-tomography-for-radiation-therapy-planning-dosimetric-effects-and-impact-of-metal-artifact-reduction
#4
Drosoula Giantsoudi, Bruno De Man, Joost Verburg, Alexei Trofimov, Yannan Jin, Ge Wang, Lars Gjesteby, Harald Paganetti
A significant and increasing number of patients receiving radiation therapy present with metal objects close to, or even within, the treatment area, resulting in artifacts in computed tomography (CT) imaging, which is the most commonly used imaging method for treatment planning in radiation therapy. In the presence of metal implants, such as dental fillings in treatment of head-and-neck tumors, spinal stabilization implants in spinal or paraspinal treatment or hip replacements in prostate cancer treatments, the extreme photon absorption by the metal object leads to prominent image artifacts...
March 21, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28323592/measuring-uptake-and-elimination-of-nitrogen-in-humans-at-different-ambient-pressures
#5
Patrik Sundblad, Oskar Frånberg, Christoph Siebenmann, Mikael Gennser
BACKGROUND: To measure nitrogen (N2) wash-out and uptake requires elaborate set-ups, especially when doing the measurements at increased or decreased ambient pressure. Here we present a transportable device for quantifying N2 turnover in humans which can be used at different ambient pressures. METHODS: A modified close-circuit electronic rebreather was used to assess N2 turnover. Changes in N2 volume within the rebreathing circuit, reflecting N2 uptake or washout, were derived from the continuously monitored total system volume and the calculated volumes of oxygen and water vapor...
December 1, 2016: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28319845/surface-transport-processes-in-charged-porous-media
#6
Jorge Gabitto, Costas Tsouris
Surface transport processes are very important in chemistry, colloidal sciences, engineering, biology, and geophysics. Natural or externally produced charges on surfaces create electrical double layers (EDLs) at the solid-liquid interface. The existence of the EDLs produces several complex processes including bulk and surface transport of ions. In this work, a model is presented to simulate bulk and transport processes in homogeneous porous media comprising big pores. It is based on a theory for capacitive charging by ideally polarizable porous electrodes without Faradaic reactions or specific adsorption of ions...
March 3, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28319499/developmental-venous-anomalies-mimicking-neoplasm-on-11c-methionine-pet-and-dsc-perfusion-mri
#7
Julie H Harreld, Mikhail Doubrovin, Elizabeth R Butch, Angela Edwards, Barry Shulkin
Elevated relative cerebral blood volume on perfusion MRI and increased uptake on C-methionine PET can be used to diagnose and guide biopsy of brain tumors but are not specific. We report increased uptake on C-methionine PET associated with 4 developmental venous anomalies (DVAs) in 3 children with brain tumors, which could potentially mimic tumor and misdirect biopsy. Because DVAs are not readily visible on CT, prevention of misdirected biopsy in patients with focally elevated C-methionine uptake and relative cerebral blood volume relies on close correlation with contrast-enhanced anatomic MRI to exclude DVA or other nonneoplastic etiology...
March 17, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28319054/association-of-attention-deficit-hyperactivity-disorder-and-autism-spectrum-disorders-with-mean-platelet-volume-and-vitamin-d
#8
Mesut Garipardic, Murat Doğan, Keziban Asli Bala, Tuba Mutluer, Sultan Kaba, Oktay Aslan, Lokman Üstyol
BACKGROUND The purpose of this study was to assess the values of the mean platelet volume (MPV) in children with attention deficit hyperactivity disorder (ADHD) and with autism spectrum disorders (ASDs) to determine the risk of cardiovascular disease in these 2 disorder groups. MATERIAL AND METHODS The study included a total of 79 patients with ADHD or ASDs and controls in the Van region of Turkey. The control group included subjects of matching age and sex with no ADHD, ASDs, or chronic disease and taking no vitamins...
March 20, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28315948/-18f-fmiso-pet-study-of-hypoxia-in-gliomas-before-surgery-correlation-with-molecular-markers-of-hypoxia-and-angiogenesis
#9
Lien Bekaert, Samuel Valable, Emmanuèle Lechapt-Zalcman, Keven Ponte, Solène Collet, Jean-Marc Constans, Guénaëlle Levallet, Karim Bordji, Edwige Petit, Pierre Branger, Evelyne Emery, Alain Manrique, Louisa Barré, Myriam Bernaudin, Jean-Sébastien Guillamo
PURPOSE: Hypoxia in gliomas is associated with tumor resistance to radio- and chemotherapy. However, positron emission tomography (PET) imaging of hypoxia remains challenging, and the validation of biological markers is, therefore, of great importance. We investigated the relationship between uptake of the PET hypoxia tracer [18F]-FMISO and other markers of hypoxia and angiogenesis and with patient survival. PATIENTS AND METHODS: In this prospective single center clinical study, 33 glioma patients (grade IV: n = 24, III: n = 3, and II: n = 6) underwent [18F]-FMISO PET and MRI including relative cerebral blood volume (rCBV) maps before surgery...
March 18, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28314539/immediate-effects-of-lumacaftor-ivacaftor-administration-on-lung-function-in-patients-with-severe-cystic-fibrosis-lung-disease
#10
Natalia Popowicz, Jamie Wood, Anna Tai, Sue Morey, Siobhain Mulrennan
Safety-data for lumacaftor/ivacaftor (LUM/IVA) combination therapy in patients with severe lung disease (percent predicted forced expiratory volume in 1s [ppFEV1] <40) remain limited. We report immediate post-dose respiratory-related adverse events in 12 patients with severe cystic fibrosis (CF) lung disease (median [IQR] ppFEV1: 34 [31-36]) prescribed LUM/IVA. All patients experienced a decline in ppFEV1 from baseline at 2-hours (median [IQR] relative change: -19 [-21 to -11]%, p<0.001) that persisted at 24-hours but recovered in most patients at 1-month...
March 14, 2017: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/28303745/grid-therapy-using-high-definition-multileaf-collimators-realizing-benefits-of-the-bystander-effect
#11
Valery Peng, Natalka Suchowerska, Linda Rogers, Elizabeth Claridge Mackonis, Samantha Oakes, David R McKenzie
BACKGROUND: In microbeam radiotherapy (MRT), parallel arrays of high-intensity synchrotron x-ray beams achieve normal tissue sparing without compromising tumor control. Grid-therapy using clinical linacs has spatial modulation on a larger scale and achieves promising results for palliative treatments of bulky tumors. The availability of high definition multileaf collimators (HDMLCs) with 2.5 mm leaves provides an opportunity for grid-therapy to more closely approach MRT. However, challenges to the wider implementation of grid-therapy remain because spatial modulation of the target volume runs counter to current radiotherapy practice and mechanisms for the beneficial effects of MRT are not fully understood...
March 17, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28302713/family-cord-blood-banking-for-sickle-cell-disease-a-twenty-year-experience-in-two-dedicated-public-cord-blood-banks
#12
Hanadi Rafii, Françoise Bernaudin, Helene Rouard, Valérie Vanneaux, Annalisa Ruggeri, Marina Cavazzana, Valerie Gauthereau, Aurélie Stanislas, Malika Benkerrou, Mariane De Montalembert, Christele Ferry, Robert Girot, Cecile Arnaud, Annie Kamdem, Joelle Gour, Claudine Touboul, Audrey Cras, Mathieu Kuentz, Claire Rieux, Fernanda Volt, Barbara Cappelli, Karina T Maio, Annalisa Paviglianiti, Chantal Kenzey, Jerome Larghero, Eliane Gluckman
Efforts to implement family cord blood banking have been developed in the past decades for siblings requiring stem cell transplantation for conditions such as sickle cell disease. However, public banks are faced with challenging decisions about the units to be stored, discarded, or used for other endeavors. We report here 20 years of experience in family cord blood banking for sickle cell disease in two dedicated public banks. Participants were pregnant women who had previous child diagnosed with homozygous sickle cell disease...
March 16, 2017: Haematologica
https://www.readbyqxmd.com/read/28301774/geometric-principles-for-designing-highly-symmetric-self-assembling-protein-nanomaterials
#13
Todd O Yeates
Emerging protein design strategies are enabling the creation of diverse, self-assembling supramolecular structures with precision on the atomic scale. The design possibilities include various types of architectures: finite cages or shells, essentially unbounded two-dimensional and three-dimensional arrays (i.e., crystals), and linear or tubular filaments. In nature, structures of those types are generally symmetric, and, accordingly, symmetry provides a powerful guide for developing new design approaches. Recent design studies have produced numerous protein assemblies in close agreement with geometric specifications...
February 23, 2017: Annual Review of Biophysics
https://www.readbyqxmd.com/read/28301763/lovesick-how-couples-relationships-influence-health
#14
Janice K Kiecolt-Glaser, Stephanie J Wilson
This review highlights recent advances in research addressing intimate partner relationships and health. Consideration of the strong mutual influences that the members of a couple have on each other's mental and physical health trajectories provides a new way to view the health implications of couples' convergence or interdependence; marital closeness can have a clear downside when one partner has mental or physical health problems. Couples' interconnectedness can also be leveraged to promote better treatment outcomes...
March 16, 2017: Annual Review of Clinical Psychology
https://www.readbyqxmd.com/read/28300028/comparison-of-allogeneic-and-syngeneic-rat-glioma-models-by-using-mri-and-histopathologic-evaluation
#15
Elena Biasibetti Alberto Valazza Maria T Capucchio Laura Annovazzi Luigi Battaglia Daniela Chirio Marina Gallarate Marta Mellai Elisabetta Muntoni Elena Peira Chiara Riganti Davide Schiffer Pierpaolo Panciani And Michele Lanotte
Research in neurooncology traditionally requires appropriate in vivo animal models, on which therapeutic strategies aretestedbefore human trials are designed and proceed. Several reproducible animal experimental models, in which human physiologic conditions can be mimicked, are available for studying glioblastoma multiforme. In an ideal rat model, the tumor is of glial origin,grows in predictable and reproducible patterns, closely resembles human gliomas histopathologically, and is weakly or nonimmunogenic...
March 15, 2017: Comparative Medicine
https://www.readbyqxmd.com/read/28299687/a-mini-electrochemical-system-with-integrated-micropipet-tip-and-pencil-graphite-electrode-for-measuring-cytotoxicity
#16
Dong-Mei Wu, Xiao-Ling Guo, Qian Wang, Jin-Lian Li, Ji-Wen Cui, Shi Zhou, Su-E Hao
A novel mini-electrochemical system has been developed for evaluating cytotoxicity of anticancer drugs based on trace cell samples. The mini-electrochemical system was integrated by using pencil graphite modified with threonine as working electrode, an Ag/AgCl reference electrode and a micropipet tip as electrochemical cell. The mini-electrochemical system dramatically reduces sample volumes from 500 μL in a traditional electrochemical system to 10 μL, and exhibits excellent electrocatalytic activity toward oxidation of purine from MCF-7 cells due to increased sensitivity provided by threonine...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28298013/does-subjective-improvement-in-adults-with-intracranial-arachnoid-cysts-justify-surgical-treatment
#17
Katrin Rabiei, Per Hellström, Mats Högfeldt-Johansson, Magnus Tisell
OBJECTIVE Subjective improvement of patients who have undergone surgery for intracranial arachnoid cysts has justified surgical treatment. The current study aimed to evaluate the outcome of surgical treatment for arachnoid cysts using standardized interviews and assessments of neuropsychological function and balance. The relationship between arachnoid cyst location, postoperative improvement, and arachnoid cyst volume was also examined. METHODS The authors performed a prospective, population-based study. One hundred nine patients underwent neurological, neuropsychological, and physiotherapeutic examinations...
February 17, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28298006/nuclear-magnetic-resonance-diffusion-pore-imaging-experimental-phase-detection-by-double-diffusion-encoding
#18
Kerstin Demberg, Frederik Bernd Laun, Johannes Windschuh, Reiner Umathum, Peter Bachert, Tristan Anselm Kuder
Diffusion pore imaging is an extension of diffusion-weighted nuclear magnetic resonance imaging enabling the direct measurement of the shape of arbitrarily formed, closed pores by probing diffusion restrictions using the motion of spin-bearing particles. Examples of such pores comprise cells in biological tissue or oil containing cavities in porous rocks. All pores contained in the measurement volume contribute to one reconstructed image, which reduces the problem of vanishing signal at increasing resolution present in conventional magnetic resonance imaging...
February 2017: Physical Review. E
https://www.readbyqxmd.com/read/28297450/dosimetric-comparison-between-cone-iris-based-and-incise-mlc-based-cyberknife-plans-for-single-and-multiple-brain-metastases
#19
Si Young Jang, Ron Lalonde, Cihat Ozhasoglu, Steven Burton, Dwight Heron, M Saiful Huq
We performed an evaluation of the CyberKnife InCise MLC by comparing plan qualities for single and multiple brain lesions generated using the first version of InCise MLC, fixed cone, and Iris collimators. We also investigated differences in delivery efficiency among the three collimators. Twenty-four patients with single or multiple brain mets treated previously in our clinic on a CyberKnife M6 using cone/Iris collimators were selected for this study. Treatment plans were generated for all lesions using the InCise MLC...
September 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28297426/mri-geometric-distortion-impact-on-tangential-whole-breast-imrt
#20
Amy Walker, Peter Metcalfe, Gary Liney, Vikneswary Batumalai, Kylie Dundas, Carri Glide-Hurst, Geoff P Delaney, Miriam Boxer, Mei Ling Yap, Jason Dowling, David Rivest-Henault, Elise Pogson, Lois Holloway
The purpose of this study was to determine the impact of magnetic resonance imaging (MRI) geometric distortions when using MRI for target delineation and planning for whole-breast, intensity-modulated radiotherapy (IMRT). Residual system distortions and combined systematic and patient-induced distortions are considered. This retrospective study investigated 18 patients who underwent whole-breast external beam radiotherapy, where both CT and MRIs were acquired for treatment planning. Distortion phantoms were imaged on two MRI systems, dedicated to radiotherapy planning (a wide, closed-bore 3T and an open-bore 1T)...
September 2016: Journal of Applied Clinical Medical Physics
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