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https://www.readbyqxmd.com/read/28636208/a-phase-i-trial-of-prn1008-a-novel-reversible-covalent-inhibitor-of-bruton-s-tyrosine-kinase-in-healthy-volunteers
#1
Patrick F Smith, Janakan Krishnarajah, Philip A Nunn, Ron J Hill, Dane Karr, D Tam, Mohammad Masjedizadeh, Jens O Funk, Steve G Gourlay
AIM: To evaluate the safety, tolerability, and PK/PD of PRN1008, a novel BTK inhibitor, in healthy volunteers, and thus determine the dose range for future clinical studies. METHODS: This was a two-part randomized, placebo controlled study in healthy volunteers using a liquid formulation. Part I was a single ascending dose design with dose levels of 50 to 1200 mg (n=6 active, 2 placebo per cohort); Part II was a multiple ascending dose design, with dose regimens ranging from 300 mg to 900 mg daily, either qd or bd for 10 days...
June 21, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28631386/toward-establishing-model-organisms-for-marine-protists-successful-transfection-protocols-for-parabodo-caudatus-kinetoplastida-excavata
#2
Fatma Gomaa, Paulo A Garcia, Jennifer Delaney, Peter R Girguis, Cullen R Buie, Virginia P Edgcomb
We developed protocols for, and demonstrated successful transfection of, the free-living kinetoplastid flagellate Parabodo caudatus with three plasmids carrying a fluorescence reporter gene (pEF-GFP with the EF1 alpha promoter, pUB-GFP with Ubiquitin C promoter, and pEYFP-Mitotrap with CMV promoter). We evaluated three electroporation approaches: 1) a square-wave electroporator designed for eukaryotes, 2) a novel microfluidic transfection system employing hydrodynamically-controlled electric field waveforms, and 3) a traditional exponential decay electroporator...
June 19, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28630717/arthroscopic-hip-preservation-surgery-practice-patterns-an-international-survey
#3
Kevin M Smith, Brayden J Gerrie, Patrick C McCulloch, Brian D Lewis, R Chad Mather, Geoffrey Van Thiel, Shane J Nho, Joshua D Harris
To design and conduct a survey analyzing pre-, intra- and post- hip arthroscopy practice patterns among hip arthroscopists worldwide. A 21-question, IRB-exempt, HIPAA-compliant, cross-sectional survey was conducted via email using SurveyMonkey to examine pre-operative evaluation, intra-operative techniques and post-operative management. The survey was administered internationally to 151 hip arthroscopists identified from publicly available sources. Seventy-five respondents completed the survey (151 ± 116 hip arthroscopy procedures per year; 8...
January 2017: Journal of Hip Preservation Surgery
https://www.readbyqxmd.com/read/28630465/changes-in-pore-structure-of-coal-caused-by-coal-to-gas-bioconversion
#4
Rui Zhang, Shimin Liu, Jitendra Bahadur, Derek Elsworth, Yi Wang, Guanglong Hu, Yanna Liang
Microbial enhanced coalbed methane (ME-CBM) recovery is critically examined as a viable technology for natural gas recovery from coalbed methane (CBM) reservoirs. Since the majority of gas-in-place (GIP) is stored as an adsorbed phase in fine pores of coal matrix, the nano-pore structure directly influences gas storage and transport properties. Only limited studies have quantified the alteration of the nano-pore structure due to ME-CBM treatment. This study examines the evolution of the pore structure using a combination of small angle X-ray scattering (SAXS), low-pressure N2 and CO2 adsorption (LPGA) and high-pressure methane adsorption methods...
June 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28630396/comparison-of-lavage-techniques-for-preventing-incision-infection-following-posterior-lumbar-interbody-fusion
#5
Jun Fei, Jianhua Gu
BACKGROUND The main purpose of this study was to compare the effects of various lavage techniques - traditional saline lavage (SL), pulse lavage (PL), closed drainage (CD), and iodine lavage (IL) - on preventing incision-related infection after posterior lumbar interbody fusion. MATERIAL AND METHODS Patients with prolapsed lumbar (intervertebral) discs (PLID) undergoing posterior lumbar interbody fusion surgery (PLIF) over the course of 2 years were included and were randomly allocated into 4 groups: the SL group, the PL group, the CD group, and the IL group...
June 20, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28628271/surgical-treatment-of-trans-sphincteric-anal-fistulas-with-the-fat-graft-technique-a-minimally-invasive-procedure
#6
N Stroumza, G Fuzco, J Laporte, R Nail Barthelemy, S Houry, M Atlan
AIM: Anal fistulas are common pathologies with a significant social impact; however their treatment is often complex and the recurrence rate can be significant. Some surgical treatments for fistula are also associated with the risk of sphincter injury. In this technical note, we aim to evaluate the feasibility and efficacy of the Fat GRAFT technique (Fat Grafting in Anal Fistula Treatment) in the treatment of recurrent anal fistulas. METHOD: All patients presenting with recurrent trans-sphincteric anal fistulas over an 18-month period were included...
June 19, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28627821/the-value-of-serum-complement-c1q-in-the-diagnosis-of-acute-ischemic-stroke
#7
Xiaowen Zhao, Changmin Wang, Baojun Pang, Yingnan Zhu, Yi Zhang
BACKGROUND: To investigate the relationship between the levels of serum complement C1q and the risk and severity of acute ischemic stroke, a total of 154 patients with acute ischemic stroke and 42 healthy volunteers as normal controls were enrolled in the present study. METHODS: According to the onset time of stroke, patients were divided into three groups. Using an immune transmission turbidity method, the levels of serum complement C1q were detected to investigate the relationship between the level of serum complement C1q and the incidence and severity of acute ischemic stroke...
May 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28627504/nature-of-the-spin-glass-phase-in-dense-packings-of-ising-dipoles-with-random-anisotropy-axes
#8
Juan J Alonso, Bartolome Alles
Using tempered Monte Carlo simulations, we study the the spin-glass phase of dense packings of Ising dipoles pointing along random axes. We consider systems of dipoles (i) placed on the sites of a simple cubic lattice with lattice constant d, and (ii) placed at the center of random close packed spheres of diameter d that occupy a 64% of the volume. For both cases we find a spin-glass phase below a certain temperature T_sg . By analysing the data obtained for the overlap parameter, the associated correlation length, as well as the statistics of the overlap distributions of individual samples, we find a behavior consistent with quasi-long-range order in the spin-glass phase, similar to the one previously found in strongly diluted dipolar systems...
June 19, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28626551/pickering-emulsions-stabilized-by-coloured-organic-pigment-particles
#9
Bernard P Binks, Samuel O Olusanya
The possibility of stabilizing emulsions of water and non-polar alkane with pure, coloured organic pigment particles is explored. Seven pigment types each possessing a primary colour of the rainbow were selected. Their solubility in water or heptane was determined using a spectrophotometric method and their surface energies were derived from the contact angles of probe liquids on compressed disks of the particles. As expected, most of the pigments are relatively hydrophobic but pigment orange is quite hydrophilic...
January 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28625725/closing-the-gap-counting-and-sizing-of-particles-across-submicron-range-by-flow-cytometry-in-therapeutic-protein-products
#10
Liling Zhang, Shuai Shi, Valentyn Antochshuk
Quantification and size distribution characterization of subvisible particles in parenteral biopharmaceutics, present as both proteinaceous and nonproteinaceous particles in the size range from 0.1-100 μm, are important for biopharmaceutical industry due to their potential safety and efficacy implications. While a number of analytical techniques are available to count and size subvisible particles, characterization of particles ≤ 2 μm remains a significant challenge due to technical limitations of existing particle counting instruments...
June 15, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28622752/microvascular-fluid-exchange-during-cpb-with-deep-hypothermia-circulatory-arrest-or-low-flow
#11
Bjørg Elvevoll, Paul Husby, Venny L Kvalheim, Lodve Stangeland, Arve Mongstad, Øyvind S Svendsen
OBJECTIVE: Use of deep hypothermic low-flow (DHLF) cardiopulmonary bypass (CPB) has been associated with higher fluid loading than the use of deep hypothermia circulatory arrest (DHCA). We evaluated whether these perfusion strategies influenced fluid extravasation rates and edema generation differently per-operatively. MATERIALS AND METHODS: Twelve anesthetized pigs, randomly allocated to DHLF (n = 6) or DHCA (n = 6), underwent 2.5 hours CPB with cooling to 20°C for 30 minutes (min), followed by 30 min arrested circulation (DHCA) or 30 min low-flow circulation (DHLF) before 90 min rewarming to normothermia...
June 1, 2017: Perfusion
https://www.readbyqxmd.com/read/28622388/correlation-of-ultrasound-bladder-vibrometry-assessment-of-bladder-compliance-with-urodynamic-study-results
#12
Mahdi Bayat, Viksit Kumar, Max Denis, Jeremy Webb, Adriana Gregory, Mohammad Mehrmohammadi, Mathew Cheong, Douglas Husmann, Lance Mynderse, Azra Alizad, Mostafa Fatemi
PURPOSE OR OBJECTIVE: The objective of this study is to assess correlation between bladder wall mechanical properties obtained by ultrasound bladder vibrometry (UBV) and urodynamic study (UDS) measurements in a group of patients undergoing clinical UDS procedure. MATERIALS AND METHODS: Concurrent UBV and UDS were performed on 70 patients with neurogenic bladders (56 male and 14 female). Bladder wall mechanical properties measured by UBV at different filling volumes were correlated with recorded detrusor pressure (Pdet) values...
2017: PloS One
https://www.readbyqxmd.com/read/28619178/changes-in-subcortical-shape-and-cognitive-function-in-patients-with-chronic-insomnia
#13
Dae Lim Koo, Jeong-Hyeon Shin, Jae-Sung Lim, Joon-Kyung Seong, Eun Yeon Joo
OBJECTIVE: The aim of this study was to examine morphological changes in subcortical structures via surface-based analysis and to correlate local shape changes with cognitive function. METHODS: We analyzed subcortical brain morphology and compared the shape changes with clinical and neuropsychological features in patients with chronic insomnia. RESULTS: Hippocampal atrophy was associated with higher Pittsburgh Sleep Quality Index scores (r = -0...
July 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28618745/effects-of-a-closed-system-suction-connector-on-airway-resistance-in-ventilated-neonates
#14
Sezin Ünal, Ebru Ergenekon, Ebru Kazanci, Selma Aktaş, Ferit Kulali, İbrahim Murat Hirfanoğlu, Canan Türkyilmaz, Yıldız Atalay
BACKGROUND/AIM: Increased airway resistance reduces the effectiveness of ventilation treatment. Endotracheal tubes (ETTs) and connectors contribute to resistance. However, the effect of a closed system suction (CSS) connector is not well known. We compared the in vivo resistance occurring with a CSS connector with that of the standard connector. MATERIALS AND METHODS: This prospective study was conducted at Gazi University Hospital's neonatal intensive care unit...
June 12, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28618160/vaccinia-virus-a11-is-required-for-membrane-rupture-and-viral-membrane-assembly
#15
Cristina Suarez, Simone Hoppe, Esthel Pénard, Paul Walther, Jacomine Krijnse Locker
While most enveloped viruses acquire their membrane from the host by budding or a wrapping process, collective data argue that nucleo-cytoplasmic large DNA viruses (NCLDVs) may be an exception. The prototype member of NCLDVs, vaccinia virus (VACV) may induce rupture of ER-derived membranes to build an open membrane sphere that closes after DNA uptake. This unconventional membrane assembly pathway is also used by at least three other members of the NCLDVs. In this study we identify the VACV gene product of A11, as required for membrane rupture, hence for VACV-membrane assembly and virion formation...
June 15, 2017: Cellular Microbiology
https://www.readbyqxmd.com/read/28613303/buckling-in-armored-droplets
#16
François Sicard, Alberto Striolo
The buckling mechanism in droplets stabilized by solid particles (armored droplets) is tackled at a mesoscopic level using dissipative particle dynamics simulations. We consider one spherical water droplet in a decane solvent coated with nanoparticle monolayers of two different types: Janus (particles whose surface shows two regions with different wetting properties) and homogeneous. The chosen particles yield comparable initial three-phase contact angles, selected to maximize the adsorption energy at the interface...
June 14, 2017: Nanoscale
https://www.readbyqxmd.com/read/28612863/in-mofs-based-on-amide-functionalised-flexible-linkers
#17
J Haddad, G F S Whitehead, A P Katsoulidis, M J Rosseinsky
Two new amide functionalised metal-organic frameworks, In(OH)CSA and In(OH)PDG, were synthesized using two flexible linkers, N-(4-carboxyphenyl)succinamic acid (CSA) and N,N'-(1,4-phenylenedicarbonyl)diglycine (PDG), respectively. Both structures consist of corner-sharing {InO4(OH)2} octahedra in the form of trans indium hydroxide chains, which are interconnected by the dicarboxylate linkers to form stacked 2-dimensional layers. The different symmetries and configurations of the flexible and rigid features on the linkers results in different supramolecular interactions dominating between linkers, resulting in different shaped pores and functional group orientation...
June 14, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/28612555/-bone-morphogenetic-proteins-from-ct26-regulate-the-expression-of-pd-l1-in-murine-dendritic-cells-and-macrophages
#18
Mao-Yuan Zhao, Yu-Yi Wang, Chi Du, Feng Luo
OBJECTIVES: To analyze the influence of bone morphogenetic proteins (BMPs) from CT26 on PD-L1 of dendritic cells and macrophages. METHODS: In vivo, we respectively inoculated CT26 colon cancer cells subcutaneously and intraperitoneally to BALB/c mice.The mice were randomly assigned to three groups and treated with normal saline; BMPs inhibitor LDN193189; BMPs inhibitor LDN193189 combined with paclitaxel, respectively. The treatments started on the eighth day after inoculating, when the tumor volume reached 150 mm(3) or the abdominal circumference was greater than 6 cm...
January 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28610569/a-novel-tamponade-agent-for-management-of-post-partum-hemorrhage-adaptation-of-the-xstat-mini-sponge-applicator-for-obstetric-use
#19
Maria I Rodriguez, Jeffrey T Jensen, Kenton Gregory, Mary Bullard, Paul Longo, Jerry Heidel, Alison Edelman
BACKGROUND: Although uterine tamponade is an effective treatment for postpartum hemorrhage (PPH), current methods have key limitations in their use, particularly in low resource settings. The XStat™ Mini Sponge Dressing (MSD) is approved for the management of non-compressible wounds in the battlefield/trauma setting. The MSD applies highly compressed medical sponges capable of stopping high-flow arterial bleeding within seconds. The objective of our study was to adopt the MSD for use in managing PPH...
June 13, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28610458/large-scale-parallel-genome-assembler-over-cloud-computing-environment
#20
Arghya Kusum Das, Praveen Kumar Koppa, Sayan Goswami, Richard Platania, Seung-Jong Park
The size of high throughput DNA sequencing data has already reached the terabyte scale. To manage this huge volume of data, many downstream sequencing applications started using locality-based computing over different cloud infrastructures to take advantage of elastic (pay as you go) resources at a lower cost. However, the locality-based programming model (e.g. MapReduce) is relatively new. Consequently, developing scalable data-intensive bioinformatics applications using this model and understanding the hardware environment that these applications require for good performance, both require further research...
May 23, 2017: Journal of Bioinformatics and Computational Biology
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