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https://www.readbyqxmd.com/read/29144558/association-of-oxidative-stress-with-clinical-characteristics-in-patients-with-rheumatoid-arthritis
#1
Sinan Kardeş, Mine Karagülle, İlker Durak, Aslıhan Avcı, Müfit Zeki Karagülle
BACKGROUND: Few studies examining the association between oxidative stress and clinical parameters or disease activity in rheumatoid arthritis (RA) patients are available. Therefore, the objective of this study was to test whether oxidative stress has any association with clinical parameters and disease activity in patients with RA. MATERIALS AND METHODS: In this post hoc cross-sectional study, 45 RA patients treated with traditional disease-modifying antirheumatic drugs (DMARDs) ± low-dose glucocorticoids ± non-steroidal analgesics for at least 3 months were analyzed...
November 16, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29073617/preimplantation-factor-pif-promotes-hla-g-e-f-c-expression-in-jeg-3-choriocarcinoma-cells-and-endogenous-progesterone-activity
#2
Miya Soukaina Hakam, Jose Maria Miranda-Sayago, Soren Hayrabedyan, Krassimira Todorova, Patrick Simon Spencer, Asma Jabeen, Eytan R Barnea, Nelson Fernandez
BACKGROUND/AIMS: Pregnancy success requires mandatory maternal tolerance of the semi/ allogeneic embryo involving embryo-derived signals. Expression levels of PreImplantation Factor (PIF), a novel peptide secreted by viable embryos, correlate with embryo development, and its early detection in circulation correlates with a favourable pregnancy outcome. PIF enhances endometrial receptivity to promote embryo implantation. Via the p53 pathway, it increases trophoblast invasion, improving cell survival / immune privilege...
October 27, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29069304/estradiol-dependent-stimulation-and-suppression-of-gonadotropin-releasing-hormone-gnrh-neuron-firing-activity-by-corticotropin-releasing-hormone-crh-in-female-mice
#3
Chayarndorn Phumsatitpong, Suzanne M Moenter
GnRH neurons are the final central regulators of reproduction, integrating various inputs that modulate fertility. Stress typically inhibits reproduction but can be stimulatory; stress effects can also be modulated by steroid milieu. CRH released during the stress response may suppress reproduction independent of downstream glucocorticoids. We hypothesized CRH suppresses fertility by decreasing GnRH neuron firing activity. To test this, mice were ovariectomized and either implanted with an estradiol capsule (OVX+E) or not treated further (OVX) to examine the influence of estradiol on GnRH neuron response to CRH...
October 20, 2017: Endocrinology
https://www.readbyqxmd.com/read/29051981/preoperative-optimization-of-patients-with-inflammatory-bowel-disease-undergoing-gastrointestinal-surgery-a-systematic-review
#4
REVIEW
Marie Strøm Zangenberg, Nir Horesh, Uri Kopylov, Alaa El-Hussuna
PURPOSE: Surgical management of inflammatory bowel disease (IBD) is a challenging task. The aim of preoperative optimization (PO) is to decrease the risk of complications and reduce the length of postoperative stay. The aim of this study was to review and grade the available evidence, attain clear recommendations, and point out potential future research. METHODS: Studies were identified from electronic databases (PubMed, Embase, and Cochrane Library) and scanning reference lists in relevant papers...
October 19, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29024164/understanding-role-of-steroids-in-typical-and-atypical-brain-development-advantages-of-using-a-brain-in-a-dish-approach
#5
REVIEW
Dwaipayan Adhya, Emily Annuario, Madeline A Lancaster, Jack Price, Simon Baron-Cohen, Deepak P Srivastava
Steroids have an important role in growth, development, sexual differentiation and reproduction. All four classes of steroids, androgens, estrogens, progestogens and glucocorticoids, have varying effects on the brain. Androgens and estrogens are involved in the sexual differentiation of the brain, and also influence cognition. Progestogens such as progesterone and its metabolites have been shown to be involved in neuroprotection, although their protective effects are timing dependent. Glucocorticoids are linked with stress and memory performance, also in a dose- and time-dependent manner...
October 12, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/28991360/low-dose-naltrexone-a-novel-treatment-for-hailey-hailey-disease
#6
V Campbell, C McGrath, A Corry
Hailey-Hailey disease (chronic benign familial pemphigus) is a rare inherited dermatosis typically characterised by erosions at intertriginous sites preceded by minor trauma or stress. We report a case of treatment resistant Hailey-Hailey disease, having failed topical and oral steroids, prophylactic acyclovir and doxycycline, and systemic therapies including dapsone, acitretin and ciclosporin. Low dose naltrexone (LDN) 4.5mg one daily was commenced following an incidental benefit in this patient's similarly affected sister...
October 9, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28985338/rfamide-related-peptide-3-and-the-trade-off-between-reproductive-and-ingestive-behavior
#7
Jill E Schneider, Noah A Benton, Kim A Russo, Candice M Klingerman, Wilbur P Williams, Jessica Simberlund, Amir Abdulhay, Jeremy M Brozek, Lance J Kriegsfeld
Ingestive and sex behaviors are important for individual survival and reproductive success, but when environmental energy availability is limited, individuals of many different species make a trade-off, forfeiting sex for ingestive behavior. For example, food-deprived female Syrian hamsters (Mesocricetus auratus) forego vaginal scent marking and lordosis (sex behaviors) in favor of foraging, hoarding, and eating food (ingestive behavior). Reproductive processes tend to be energetically costly, and individual survival requires homeostasis in metabolic energy...
July 27, 2017: Integrative and Comparative Biology
https://www.readbyqxmd.com/read/28968051/gps-have-key-role-in-improving-outcomes-in-acute-asthma
#8
Helen L Grover, Bernard G Higgins
Asthma deaths in the UK remain among the highest in Europe. The 2014 National Review of Asthma Deaths looked at detailed data over a 12-month period assessing 195 patients who died from asthma and highlighted the avoidable factors in patient deaths. Although faults were found in secondary care, many of the problems related to poor management of patients in the community, both in terms of regular surveillance and assessment and treatment at the onset of attacks. Features which indicate a high risk of severe attacks include: previous admission to intensive care, particularly if requiring mechanical ventilation; previous admission with asthma especially in the past year or repeated emergency admissions; history of worsening asthma in January or February; use of three or more classes of asthma medication; heavy use of beta-2 agonists; anxiety traits; and marital stress...
November 2016: Practitioner
https://www.readbyqxmd.com/read/28959852/-subacute-toxicity-metabonomics-of-jinlingzi-powder-based-on-lc-ms
#9
Shu-Jie Shen, Su-Fang Shui, Bing-Kun Xiao, Jian-Yun Yang, Rong-Qing Huang
To further understand the metabolic characteristics of Jinlingzi powder toxicity effect in rats and explore the effect of Jinlingzi powder on unknown biological pathways in the treatment process. In this experiment, the effect of three doses of Jinlingzi powder decoction on rat liver and kidney was investigated to explore the characteristics and rules of Jinlingzi powder on in vivo metabonomic changes in rats. First, urine and serum samples of the rats were used for LC-MS analysis. Under the XCMS online analysis, 44 differential substances were found in the identification of metabolites...
February 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28922579/evaluating-real-time-effects-of-topical-1-1000-epinephrine-in-endoscopic-sinus-and-skull-base-surgery-on-hemodynamic-parameters-through-intraoperative-arterial-line-monitoring
#10
Michael T Yim, Omar G Ahmed, Masayoshi Takashima
BACKGROUND: Administration of topical 1:1000 epinephrine is commonly used in practice to achieve vasoconstriction during endoscopic sinus surgery and skull-base surgery; however, real-time effects on cardiovascular changes from systemic absorption have not been well studied. METHODS: Twenty-six patients undergoing endoscopic transsphenoidal resection of a pituitary lesion at a single institution were included into the study. Following arterial line placement by anesthesiology, 6 cottonoid pledgets soaked in 1:1000 epinephrine were placed into the bilateral nasal passages...
September 18, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28873505/enhanced-recovery-after-surgery-pain-management
#11
REVIEW
Susan M Nimmo, Irwin T H Foo, Hugh M Paterson
Effective pain management is fundamental to enhanced recovery after surgery. Selection of strategies should be tailored to patient and operation. As well as improving the quality of recovery, effective analgesia reduces the host stress response, facilitates mobilization and allows resumption of oral intake. Multi-modal regimens combining paracetamol, non-steroidal anti-inflammatory agents where indicated, a potent opioid and a local anaesthetic technique achieve effective analgesia while limiting the dose and thereby side effects of any one agent...
October 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28853293/predictors-of-vasopressin-responsiveness-in-critically-ill-adults
#12
Brittainy Allen, Bridgette Kram, Shawn Kram, Jennifer Schultheis, Steven Wolf, Daniel Gilstrap, Mark Shapiro
BACKGROUND: Vasopressin is commonly used as an adjunct vasopressor in shock. However, response to vasopressin varies among critically ill patients. OBJECTIVE: To identify patient-specific factors that are associated with vasopressin responsiveness in critically ill adults. METHODS: This retrospective, multicenter study included adult patients who were admitted to an intensive care unit (ICU) and received vasopressin for shock. Patients were excluded if they received vasopressin for less than 30 minutes, if vasopressin was initiated prior to ICU arrival, or if an additional vasopressor was initiated within 30 minutes of starting vasopressin...
August 1, 2017: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/28843114/clinical-and-radiological-predictors-of-outcome-in-tubercular-meningitis-a-prospective-study-of-209-patients
#13
M Modi, K Sharma, S Prabhakar, M K Goyal, A Takkar, N Sharma, A Garg, S Faisal, N Khandelwal, P Singh, J Sachdeva, R Shree, V Rishi, V Lal
OBJECTIVES: The predictors of poor outcome in tuberculous meningitis (TBM) remain to be delineated. We determined role of various clinical, radiological and cerebrospinal fluid (CSF) parameters in prediction of outcome in TBM. PATIENTS AND METHODS: Current study was a prospective observational study including 209 patients of TBM. All patients underwent detailed evaluation including Gadolinium enhanced Magnetic resonance imaging (GdMRI) of brain as well as tests to detect evidence of tuberculosis elsewhere in body...
October 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28822384/clinical-characteristics-of-trauma-patients-requiring-hydrocortisone-treatment-for-refractory-hypotension
#14
Gina Kim, Jeffrey Young
Corticosteroids play an important role in responding to physiologic stress in the human body. However, its application in critical care remains heavily debated. The purpose of this study was to identify patient characteristics associated with receiving stress-dose steroids during the intensive care unit stay after traumatic injury and its effect on in-hospital mortality. Patients admitted to the University of Virginia trauma center between January 1, 2011, and December 31, 2015, were identified using our Trauma Registry...
August 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28808397/genistein-attenuated-gastric-injury-on-indomethacin-induced-gastropathy-in-rats
#15
Sarocha Vivatvakin, Duangporn Werawatganon, Kanjana Somanawat, Naruemon Klaikeaw, Prasong Siriviriyakul
OBJECTIVES: To investigates the mucoprotective effect of genistein on gastric injury in rats with indomethacin (IMN)-induced gastropathy. METHODS: Male Sprague-Dawley rats were randomly divided into three groups. Group 1 (control; n = 6) was given distilled water (DW). Group 2 (IMN; n = 6) was given indomethacin (IMN) 150 mg/kg dissolved in 5% sodium bicarbonate (NaHCO3(-)) 1 mL/rat via intragastric tube at time 0 and 4 h. Group 3 (genistein; n = 6) was given genistein 100 mg/kg dissolved in 0...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28776498/methylprednisolone-prevents-bacterial-translocation-in-thioacetamide-induced-liver-failure-in-rats
#16
Murat Muhsin Muhip Harputluoğlu, İsmail Temel, Ulvi Demirel, Yüksel Seçkin, Murat Aladağ, Barış Otlu, Neşe Karadağ, Fatma Özyalın, Nilay Aydoğan, Engin Burak Selçuk
BACKGROUND/AIMS: Steroids have been shown to prevent intestinal oxidative stress. We investigated the effects of methylprednisolone on intestinal oxidative damage and bacterial translocation in thioacetamide-induced liver failure in rats. MATERIALS AND METHODS: Group 1 (n=8) was the control group. In group 2 (n=8), the thioacetamide group, rats received 300 mg/kg intraperitoneal thioacetamide daily for 2 days. In group 3 (n=8), the thioacetamide+methylprednisolone group, treatment with methylprednisolone (30 mg/kg intraperitoneal) was commenced 48 h before the first dose of thioacetamide...
August 4, 2017: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/28764794/exploration-of-knowledge-and-understanding-in-patients-with-primary-adrenal-insufficiency-a-mixed-methods-study
#17
L M Shepherd, A A Tahrani, C Inman, W Arlt, D M Carrick-Sen
BACKGROUND: Primary adrenal insufficiency (PAI) is a rare and severe condition requiring lifelong steroid replacement. During acute illness or stressful events, it is important to appropriately adjust glucocorticoid dose; failure to do so may lead to an adrenal crisis. The aim of the study was to explore patients PAI knowledge and understanding of the condition, steroid replacement adjustment during acute illness or stress and provided education. METHODS: Ten adult patients with PAI were purposefully recruited from two hospitals in a tertiary NHS Trust in England, UK...
August 1, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28758231/redefining-the-stress-cortisol-response-to-surgery
#18
Bernard Khoo, Piers R Boshier, Alexander Freethy, George Tharakan, Samerah Saeed, Neil Hill, Emma L Williams, Krishna Moorthy, Neil Tolley, Long R Jiao, Duncan Spalding, Fausto Palazzo, Karim Meeran, Tricia Tan
BACKGROUND: Cortisol levels rise with the physiological stress of surgery. Previous studies have used older, less-specific assays, have not differentiated by severity or only studied procedures of a defined type. The aim of this study was to examine this phenomenon in surgeries of varying severity using a widely used cortisol immunoassay. METHODS: Euadrenal patients undergoing elective surgery were enrolled prospectively. Serum samples were taken at 8 am on surgical day, induction and 1 hour, 2 hour, 4 hour and 8 hour after...
July 31, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28750356/combined-calcitriol-and-menadione-reduces-experimental-murine-triple-negative-breast-tumor
#19
Luciana Bohl, Solange Guizzardi, Valeria Rodríguez, Lucila Hinrichsen, Viviana Rozados, David Cremonezzi, Nori Tolosa de Talamoni, Gabriela Picotto
BACKGROUND: Calcitriol (D) or 1,25(OH)2D3 inhibits the growth of several tumor cells including breast cancer cells, by activating cell death pathways. Menadione (MEN), a glutathione-depleting compound, may be used to potentiate the antiproliferative actions of D on cancer cells. We have previously shown in vitro that MEN improved D-induced growth arrest on breast cancer cell lines, inducing oxidative stress and DNA damage via ROS generation. Treatment with MEN+D resulted more effective than D or MEN alone...
October 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28721596/central-adrenal-insufficiency-following-traumatic-brain-injury-a-missed-diagnosis-in-the-critically-injured
#20
Eileen Fan, Peter W Skippen, Michael A Sargent, David D Cochrane, Jean-Pierre Chanoine
BACKGROUND: High-dose steroid administration is no longer recommended in the treatment of acute traumatic brain injury (TBI) as it failed to prove beneficial in improving patients' outcome. However, a masked benefit of steroid administration in TBI management was that it provided corticosteroid replacement therapy in patients with TBI-related central adrenal insufficiency. CASE PRESENTATION: We report the case of a 12-year-old boy who suffered a severe TBI from a motor vehicle accident that resulted in complete deficiency of anterior pituitary function...
December 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
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