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https://www.readbyqxmd.com/read/28543019/the-burden-of-chronic-spontaneous-urticaria-is-substantial-real-world-evidence-from-assure-csu
#1
Marcus Maurer, Mohamed Abuzakouk, Frédéric Bérard, Walter Canonica, Hanneke Oude Elberink, Ana Giménez-Arnau, Clive Grattan, Kelly Hollis, André Knulst, Jean-Philippe Lacour, Charles Lynde, Alexander Marsland, Doreen McBride, Alla Nakonechna, Javier Ortiz de Frutos, Christina Proctor, Gordon Sussman, Carolyn Sweeney, Haijun Tian, Karsten Weller, Daniel Wolin, Maria-Magdalena Balp
BACKGROUND: Chronic spontaneous urticaria (CSU) can be debilitating, difficult to treat, and frustrating for patients and physicians. Real-world evidence for the burden of CSU is limited. The objective of this study was to document disease duration, treatment history, and disease activity, as well as impact on health-related quality of life (HRQoL) and work among patients with inadequately controlled CSU, and to describe its humanistic, societal, and economic burden. METHODS: This international observational study assessed a cohort of 673 adult patients with CSU whose symptoms persisted for ≥12 months despite treatment...
May 19, 2017: Allergy
https://www.readbyqxmd.com/read/28542444/regional-brain-amyloid-%C3%AE-accumulation-associates-with-domain-specific-cognitive-performance-in-parkinson-disease-without-dementia
#2
Rizwan S Akhtar, Sharon X Xie, Yin J Chen, Jacqueline Rick, Rachel G Gross, Ilya M Nasrallah, Vivianna M Van Deerlin, John Q Trojanowski, Alice S Chen-Plotkin, Howard I Hurtig, Andrew D Siderowf, Jacob G Dubroff, Daniel Weintraub
Parkinson disease patients develop clinically significant cognitive impairment at variable times over their disease course, which is often preceded by milder deficits in memory, visuo-spatial, and executive domains. The significance of amyloid-β accumulation to these problems is unclear. We hypothesized that amyloid-β PET imaging by 18F-florbetapir, a radiotracer that detects fibrillar amyloid-β plaque deposits, would identify subjects with global cognitive impairment or poor performance in individual cognitive domains in non-demented Parkinson disease patients...
2017: PloS One
https://www.readbyqxmd.com/read/28538006/evaluation-and-management-of-patch-test-negative-patients-with-generalized-dermatitis
#3
Alison Spiker, Christen M Mowad
BACKGROUND: Patients with generalized dermatitis are common in dermatology practices. Allergic contact dermatitis is often suspected, and patients frequently undergo patch testing. When patch testing result is negative, further evaluation and management of these patients are challenging. OBJECTIVE: The purpose of this study was to survey members of the American Contact Dermatitis Society regarding the evaluation and management of patch test-negative patients with generalized dermatitis...
May 23, 2017: Dermatitis
https://www.readbyqxmd.com/read/28536235/a-case-of-acyclovir-neurotoxicity-presenting-with-atypical-cerebrospinal-fluid-findings
#4
Guramrinder Singh Thind, Richard Roach
An 82-year-old man with a history of end-stage renal disease presented with progressively worsening confusion and somnolence for the past 4-5 days. The patient was diagnosed with herpes zoster by his primary care physician 5 days ago and was started on a course of valacyclovir 1 g three times a day (dose not adjusted for renal impairment).A lumbar puncture was performed and cerebrospinal fluid (CSF) studies revealed 37 white blood cells (WBCs)/hpf (100% monocytes), protein 64 mg/dL and glucose 52 mg/dL...
May 22, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28535241/management-of-depression-in-older-adults-a-review
#5
Rob M Kok, Charles F Reynolds
Importance: Depression in older adults is a common psychiatric disorder affecting their health-related quality of life. Major depression occurs in 2% of adults aged 55 years or older, and its prevalence rises with increasing age. In addition, 10% to 15% of older adults have clinically significant depressive symptoms, even in the absence of major depression. Observations: Depression presents with the same symptoms in older adults as it does in younger populations...
May 23, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28533106/trans-sectoral-care-of-geriatric-cancer-patients-based-on-comprehensive-geriatric-assessment-and-patient-reported-quality-of-life-results-of-a-multicenter-study-to-develop-and-pilot-test-a-patient-centered-interdisciplinary-care-concept-for-geriatric-oncology
#6
Heike Schmidt, Stephanie Boese, Katharina Lampe, Karin Jordan, Eckhard Fiedler, Ursula Müller-Werdan, Andreas Wienke, Dirk Vordermark
OBJECTIVES: For older patients with cancer the maintenance of independence, functionality and health-related quality of life (HRQOL) is of great importance. Aiming to maintain HRQOL of older patients with cancer we developed an interdisciplinary care program based on comprehensive geriatric assessment (CGA) and patient-reported HRQOL comprising tailored supportive measures and telephone-based counseling during 6month aftercare. MATERIALS AND METHODS: Pilot-testing of the intervention took place in three centers at the University Hospital Halle to examine feasibility, acceptance and potential benefit...
May 19, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28530076/-osteoporosis-and-diabetes-in-which-way-are-they-related
#7
REVIEW
Osnat Tell-Lebanon, Pnina Rotman-Pikielny
Diabetes and osteoporosis are common diseases with growing prevalence in the aging population. Many recent studies have reported an association between diabetes mellitus and an increased osteoporotic fracture rate. Compared to control subjects, decreased bone mineral density has been observed in patients with type 1 diabetes mellitus, while those with type 2 diabetes display a unique skeletal phenotype of increased bone mineral density, but impaired architectural structure and mineral properties. Accumulation of advanced glycation end products changes collagen structure and suppression of bone turnover causes impairment of repair and adaptation mechanisms...
November 2016: Harefuah
https://www.readbyqxmd.com/read/28525629/the-association-of-perceived-memory-loss-with-osteoarthritis-and-related-joint-pain-in-a-large-appalachian-population
#8
Kim E Innes, Usha Sambamoorthi
Objective. : Previous studies have documented memory impairment in several chronic pain syndromes. However, the potential link between memory loss and osteoarthritis (OA), the second most common cause of chronic pain, remains little explored. In this cross-sectional study, we examine the association of perceived memory loss to OA and assess the potential mediating influence of sleep and mood disturbance in a large Appalachian population. Design.:  Cross-sectional...
May 19, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28525252/-medical-supply-planning-dynamic-registry-of-physicians-sixth-reform-of-the-state-and-numerus-clausus
#9
N Benahmed, A De Wever, M Pirson
INTRODUCTION: The last few years have seen major changes in the Belgian medical planning. The paper aims to describe them and to assess how they will affect the medical demography. METHOD: Grey literature review and federal and federated entities legislation summary. RESULTS: A new dynamic register allows a better knowledge of medical workforce in all sectors of labour market. Recent legislation evolutions induce fragmentation of competences related to human resource for health planning : federal authorities are responsive for the fixation of number of GP and specialists and community authorities for registration of health professionals and fixation of sub-quotas in different branches of specialised medicine...
2017: Revue Médicale de Bruxelles
https://www.readbyqxmd.com/read/28523416/utility-of-ct-oral-contrast-administration-in-the-emergency-department-of-a-quaternary-oncology-hospital-diagnostic-implications-turnaround-times-and-assessment-of-ed-physician-ordering
#10
Corey T Jensen, Katherine J Blair, Ott Le, Jia Sun, Wei Wei, Brinda Rao Korivi, Ajaykumar C Morani, Nicolaus A Wagner-Bartak
PURPOSE: To compare studies with and without oral contrast on performance of multidetector computed tomography (CT) and the order to CT examination turnaround time in cancer patients presenting to the emergency department (ED). To the best of our knowledge, oral contrast utility has not previously been specifically assessed in cancer patients presenting to the emergency department. MATERIALS & METHODS: Retrospective review of CT abdomen examinations performed in oncology patients presenting to the emergency department during one month...
May 18, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28521822/central-nervous-system-manganese-induced-lesions-and-clinical-consequences-in-patients-with-hereditary-hemorrhagic-telangiectasia
#11
M M Serra, C H Besada, A Cabana Cal, A Saenz, C V Stefani, D Bauso, A B Golimstok, J C Bandi, D H Giunta, C M Elizondo
BACKGROUND: Around 47-74% of patients with hereditary hemorrhagic telangiectasia (HHT) have hepatic vascular malformations (HVMs); magnetic resonance images (MRI) of the central nervous system (CNS) might show in T1 sequences a hyper-intensity signal in different areas, mainly in the basal ganglia (BG) as consequence of manganese (Mn) deposits as observed in cirrhotic patients. These patients might suffer from different neuropsychiatric disorders (hepatic encephalopathy). In HHT patients, even in the presence of hepatic shunts, hepatocellular function is usually preserved...
May 18, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/28516352/air-pollution-and-respiratory-health-among-diabetic-and-non-diabetic-subjects-in-pune-india-results-from-the-wellcome-trust-genetic-study
#12
Morteza Abdullatif Khafaie, Sundeep Santosh Salvi, Chittaranjan Sakerlal Yajnik, Ajay Ojha, Behzad Khafaie, Sharad Damodar Gore
Diabetics may be more vulnerable to the harmful effects of ambient air pollutants than healthy individuals. But, the risk factors that lead to susceptibility to air pollution in diabetics have not yet been identified. We examined the effect of exposure to ambient PM10 on chronic symptoms and the pulmonary function tests (PFT) in diabetic and non-diabetic subjects. Also, to investigate possible determinants of susceptibility, we recruited 400 type 2 diabetic and 465 healthy subjects who were investigated for chronic respiratory symptoms (CRSs) and then underwent measurement of forced vital capacity (FVC) and forced expiratory volume 1 (FEV1) according to standard protocol...
May 17, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28511984/comparison-of-three-cognitive-exams-in-cardiac-arrest-survivors
#13
Allison C Koller, Jon C Rittenberger, Melissa J Repine, Patrick W Morgan, Jeffrey Kristan, Clifton W Callaway
BACKGROUND: Cognitive deficits may detract from quality of life after cardiac arrest. Their pattern and prevalence are not well documented. We used the Computer Assessment of Mild Cognitive Impairment (CAMCI), the Montreal Cognitive Assessment (MOCA) and the 41 Cent Test (41CT) to assess cognitive impairment in cardiac arrest survivors and examine the exams' diagnostic accuracy. We hypothesized that the scores of these exams would indicate the presence of cognitive impairment in arrest survivors, that the overall scores on the three study assessments would correlate with one another, and that the 41CT, MOCA, and executive function element of the CAMCI would vary independently from other non-executive CAMCI components, reflecting executive function impairment after cardiac arrest...
May 13, 2017: Resuscitation
https://www.readbyqxmd.com/read/28511141/the-co-occurrence-of-depressive-symptoms-and-cognitive-impairment-and-its-relationship-with-self-care-behaviors-among-community-dwelling-older-adults-with-diabetes
#14
Chia-Lin Li, Yi-Chen Chiu, Yuh-Bin Bai, Jen-Der Lin, Fiona Stanaway, Hsing-Yi Chang
AIMS: The aims of the present study were to investigate the co-occurrence of depressive symptoms and cognitive impairment in community dwelling older adults with diabetes and its relationship with specific diabetes self-care behaviors. METHODS: We analyzed data from two national samples of older adults (65years or older) with self-reported physician-diagnosed diabetes (N=1034), who participated in the 2005 or 2009 National Health Interview Survey in Taiwan. The Mini-Mental State Examination was used to assess cognitive function...
May 5, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28506978/addition-of-blood-pressure-and-weight-transmissions-to-standard-remote-monitoring-of-implantable-defibrillators-and-its-association-with-mortality-and-rehospitalization
#15
M Obadah Al-Chekakie, Haikun Bao, Paul W Jones, Kenneth M Stein, Lucas Marzec, Paul D Varosy, Frederick A Masoudi, Jeptha P Curtis, Joseph G Akar
BACKGROUND: Among patients with implantable defibrillators (ICD), use of remote patient monitoring (RPM) is associated with lower risk of death and rehospitalization. Standard ICD RPM can be supplemented with weight and blood pressure data. It is not known whether standard RPM plus routine weight and blood pressure transmission (RPM+) is associated with better outcomes. METHODS AND RESULTS: RPM+ patients (n=4106) were compared with patients who only transmitted standard ICD RPM data (n=14 183)...
May 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/28505701/-compatibility-of-work-and-family-life-survey-of-physicians-in-the-munich-metropolitan-area
#16
Meike Lauchart, Philipp Ascher, Karin Kesel, Sabine Weber, Beatrice Grabein, Bertram Schneeweiss, Cordula Fischer-Truestedt, Michael Schoenberg, Gudrun Rogler, Claudia Borelli
Aim Investigation of the compatibility of work and family life for physicians in the Munich metropolitan area. Methods Survey of a representative sample of 1,800 physicians using a questionnaire. Results Men were less satisfied (7% very satisfied vs. 21%) with compatibility between work and family life than women. The group least satisfied overall was hospital-based physicians (p=0.000, chi-square=122.75). Women rather than men cut back their career due to children, perceived their professional advancement as impaired, desisted from establishing private practice or quit hospital employment altogether...
May 15, 2017: Das Gesundheitswesen
https://www.readbyqxmd.com/read/28505049/perceived-impairment-in-sports-participation-in-adolescents-with-inflammatory-bowel-diseases-a-preliminary-examination
#17
Jill M Plevinsky, Andrea A Wojtowicz, Natasha Poulopoulos, Kristin L Schneider, Rachel N Greenley
OBJECTIVE: Physical activity is important for adolescents with inflammatory bowel diseases (IBD) given the increased risk of developing osteoporosis and the increased risk of IBD-related complications among those with IBD and obesity. Symptoms like fatigue, abdominal pain, nausea, and frequent bowel movements can interfere with physical activity. Sports participation is an important source of physical activity for adolescents; however, the extent to which IBD interferes with sports participation is unstudied...
May 12, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28504012/inpatient-glycemic-management-in-internal-medicine-an-observational-multicenter-study-in-nanjing-china
#18
Shujie Hao, Ning Zhang, Anne Folta Fish, Xiaodan Yuan, Lin Liu, Fan Li, Zhaohui Fang, Qingqing Lou
Aims To evaluate the prevalence of hyperglycemia among inpatients in internal medicine, and specifically, to assess the glycemic management of inpatients in non-endocrinology departments in three large urban hospitals in China. Methods A multicenter observational study was conducted using electronic health records, and a survey of 1939 patients who were admitted to internal medicine units and followed until discharge. Those with previously diagnosed diabetes, newly diagnosed diabetes, or impaired fasting glucose were included...
May 13, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28501874/screening-tool-for-early-postnatal-prediction-of-retinopathy-of-prematurity-in-preterm-newborns-step-rop
#19
Caroline A Ricard, Christiane E L Dammann, Olaf Dammann
BACKGROUND: Retinopathy of prematurity (ROP) is a disorder of the preterm newborn characterized by neurovascular disruption in the immature retina that may cause visual impairment and blindness. OBJECTIVE: To develop a clinical screening tool for early postnatal prediction of ROP in preterm newborns based on risk information available within the first 48 h of postnatal life. METHODS: Using data submitted to the Vermont Oxford Network (VON) between 1995 and 2015, we created logistic regression models based on infants born <28 completed weeks gestational age...
May 13, 2017: Neonatology
https://www.readbyqxmd.com/read/28501143/do-we-know-how-to-diagnose-epilepsy-early-in-alzheimer-s-disease
#20
REVIEW
B Cretin, N Philippi, O Bousiges, L Dibitonto, F Sellal, C Martin-Hunyadi, F Blanc
Epilepsy is an increasingly recognized comorbidity in Alzheimer's disease (AD). First described as generalized in dementia patients, epileptic AD patients are nowadays fully described in earlier stages of the disease (with mild or subjective cognitive impairment). At such early stages, patients may present not only with generalized seizures, but also with focal seizures (commonly localized in the frontal or temporal lobe). Thus, partial or generalized epilepsy is part of the semiological spectrum of AD that should be borne in mind at all stages of disease to ensure early identification and prevent the risk of repeated seizures (such as accidents, injury, progression of cognitive impairment)...
May 10, 2017: Revue Neurologique
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