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https://www.readbyqxmd.com/read/29033928/unexpectedly-high-prevalence-of-common-variable-immunodeficiency-in-finland
#1
Jannica S Selenius, Timi Martelius, Sampsa Pikkarainen, Sanna Siitonen, Eero Mattila, Risto Pietikäinen, Pekka Suomalainen, Arja H Aalto, Janna Saarela, Elisabet Einarsdottir, Asko Järvinen, Martti Färkkilä, Juha Kere, Mikko Seppänen
BACKGROUND: Common variable immunodeficiency (CVID) is the most common primary immunodeficiency. Prevalence varies greatly between countries and studies. Most diagnostic criteria include hypogammaglobulinemia and impaired vaccine response. AIM: To evaluate the minimum prevalence as well as the clinical and immunological phenotypes of CVID in Southern Finland. METHODS: We performed a cross-sectional study to assess all adult CVID patients followed up in three hospital districts in Southern and South-Eastern Finland between April 2007 and August 2015...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29031616/factors-affecting-the-selection-of-an-inhaler-device-for-copd-and-the-ideal-device-for-different-patient-profiles-results-of-epoca-delphi-consensus
#2
Marc Miravitlles, Juan José Soler-Cataluña, Bernardino Alcázar, José Luis Viejo, Francisco García-Río
BACKGROUND: This study aimed to identify the relevant factors for the choice of an inhaler device by physicians and the selection of the most important characteristics of a device according to different characteristics of patients with COPD. METHOD: In this two-round Delphi survey, 96 Spanish COPD-expert pulmonologists completed an internet-based, self-administered questionnaire, which consisted of a first part with 19 items related to the prioritization of the drug or the device, the experience, ability and preference of the patient, and the experience and preferences of the healthcare professional...
October 12, 2017: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29031345/rehabilitation-needs-of-the-elderly-patient-with-cancer
#3
REVIEW
Jesuel Padro-Guzman, Jennifer P Moody, Jessica L Au
Physiatrist taking care of the geriatric patient with cancer should be able to manage an array of conditions that might present from diagnosis throughout completion of treatments and beyond. The elderly cancer population is at greater risk of functional impairments. The physician should anticipate changes in clinical status and must adjust rehabilitation goals accordingly. Treatment options and rehabilitation goals should be tailored to help maximize quality of life in these patients.
November 2017: Physical Medicine and Rehabilitation Clinics of North America
https://www.readbyqxmd.com/read/29029561/women-with-psvt-are-often-misdiagnosed-referred-later-than-men-and-have-more-symptoms-after-ablation
#4
Carina Carnlöf, Marie Iwarzon, Mats Jensen-Urstad, Fredrik Gadler, Per Insulander
OBJECTIVES: Using a patient and gender perspective, this study evaluates the experiences and perspectives of referral for paroxysmal supraventricular tachycardia (PSVT), and symptoms, Health-Related Quality of Life (HRQOL) and functional impairment before and six months after ablation. DESIGN: This prospective study includes 214 (109 women) patients with PSVT who completed questionnaires before and after ablation addressing referral patterns, duration of arrhythmia, socioeconomic status, symptoms, HRQOL, and functional impairment...
October 13, 2017: Scandinavian Cardiovascular Journal: SCJ
https://www.readbyqxmd.com/read/29029554/cross-sectional-relationships-of-physical-activity-and-sedentary-behavior-with-cognitive-function-in-older-adults-with-probable-mild-cognitive-impairment
#5
Ryan S Falck, Glenn J Landry, John R Best, Jennifer C Davis, Bryan K Chiu, Teresa Liu-Ambrose
Background: Mild cognitive impairment (MCI) represents a transition between normal cognitive aging and dementia and may represent a critical time frame for promoting cognitive health through behavioral strategies. Current evidence suggests that physical activity (PA) and sedentary behavior are important for cognition. However, it is unclear whether there are differences in PA and sedentary behavior between people with probable MCI and people without MCI or whether the relationships of PA and sedentary behavior with cognitive function differ by MCI status...
October 1, 2017: Physical Therapy
https://www.readbyqxmd.com/read/29020012/wearable-sensors-objectively-measure-gait-parameters-in-parkinson-s-disease
#6
Johannes C M Schlachetzki, Jens Barth, Franz Marxreiter, Julia Gossler, Zacharias Kohl, Samuel Reinfelder, Heiko Gassner, Kamiar Aminian, Bjoern M Eskofier, Jürgen Winkler, Jochen Klucken
Distinct gait characteristics like short steps and shuffling gait are prototypical signs commonly observed in Parkinson's disease. Routinely assessed by observation through clinicians, gait is rated as part of categorical clinical scores. There is an increasing need to provide quantitative measurements of gait, e.g. to provide detailed information about disease progression. Recently, we developed a wearable sensor-based gait analysis system as diagnostic tool that objectively assesses gait parameter in Parkinson's disease without the need of having a specialized gait laboratory...
2017: PloS One
https://www.readbyqxmd.com/read/28993037/reversible-stress-cardiomyopathy-secondary-to-aneurysmal-subarachnoid-hemorrhage-a-case-report
#7
Konstantinos Lampropoulos, Evangelos Giannoulis, Bazoukis George, Gary Tse, Epameinondas Triantafyllou, Athanasios Triantafyllou
BACKGROUND: Acute cerebral incidents have been correlated with cardiac manifestations. Specifically, subarachnoid hemorrhage has been correlated with a syndrome described as neurogenic stress cardiomyopathy and mimics acute coronary syndrome. CASE REPORT: A 55-year-old woman presented at the Emergency Department of our hospital complaining of vomiting and headache of sudden onset. Computed tomography angiography revealed a ruptured aneurysm at the tip of the basilar artery and the patient underwent a successful complete embolism of the sac of the aneurysm...
October 6, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28991827/sepsis-survivors-admitted-to-skilled-nursing-facilities-cognitive-impairment-activities-of-daily-living-dependence-and-survival
#8
William J Ehlenbach, Andrea Gilmore-Bykovskyi, Michael D Repplinger, Ryan P Westergaard, Elizabeth A Jacobs, Amy J H Kind, Maureen Smith
OBJECTIVE: Severe sepsis survivors frequently experience cognitive and physical functional impairment. The degree of impairment and its association with mortality is understudied, particularly among those discharged to a skilled nursing facility. Our objective was to quantify the cognitive and physical impairment among severe sepsis survivors discharged to a skilled nursing facility and to investigate the relationship between impairment and long-term mortality. DESIGN: Retrospective cohort study...
October 6, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28988103/opioid-tapering-in-patients-with-prescription-opioid-use-disorder-a-retrospective-study
#9
Kehua Zhou, Peng Jia, Swati Bhargava, Yong Zhang, Taslima Reza, Yuan Bo Peng, Gary G Wang
BACKGROUND AND AIMS: Opioid use disorder (OUD) refers to a maladaptive pattern of opioid use leading to clinically significant impairment or distress. OUD causes, and vice versa, misuses and abuse of opioid medications. Clinicians face daily challenges to treat patients with prescription opioid use disorder. An evidence-based management for people who are already addicted to opioids has been identified as the national priority in the US; however, options are limited in clinical practices...
October 4, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/28982484/medical-licensure-questions-and-physician-reluctance-to-seek-care-for-mental-health-conditions
#10
Liselotte N Dyrbye, Colin P West, Christine A Sinsky, Lindsey E Goeders, Daniel V Satele, Tait D Shanafelt
OBJECTIVE: To determine whether state medical licensure application questions (MLAQs) about mental health are related to physicians' reluctance to seek help for a mental health condition because of concerns about repercussions to their medical licensure. METHODS: In 2016, we collected initial and renewal medical licensure application forms from 50 states and the District of Columbia. We coded MLAQs related to physicians' mental health as "consistent" if they inquired only about current impairment from a mental health condition or did not ask about mental health conditions...
October 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/28982207/transient-receptor-potential-vanilloid-1-inhibitors-block-laparotomy-and-opioid-induced-infarct-size-reduction-in-rats
#11
Helen M Heymann, Yun Wu, Yao Lu, Nir Qvit, Garrett J Gross, Eric R Gross
BACKGROUND AND PURPOSE: In light of the opioid epidemic, physicians are increasingly prescribing non-opioid analgesics to surgical patients. Transient receptor potential vanilloid 1 (TRPV1) inhibitors are potentially alternative pain therapeutics for surgery. Here we examined in rodents whether cardioprotection conferred by two occurrences during surgery, a laparotomy or morphine delivery, is mediated by TRPV1. We further tested whether an experimental analgesic peptide (known as P5) targeted against the TRPV1 C-terminus region interferes with laparotomy- or morphine-induced cardioprotection...
October 5, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28982206/-in-exchange-with-copd-patients-towards-a-patient-oriented-communication
#12
N M Stenzel, K Kenn, G Steinkamp
The quality of life can be severely impaired in patients with COPD. In addition to physical restraints, they often suffer from psychological comorbidities (e. g. anxiety, depression). Psychological comorbidities are often associated with dysfunctional beliefs about the illness and its treatment. Such dysfunctional beliefs, in turn, are likely to negatively affect patients' quality of life as well as their communication with physicians and their illness behavior in general. It is therefore important for physicians to adapt their communication to account for patients' dysfunctional beliefs...
October 5, 2017: Pneumologie
https://www.readbyqxmd.com/read/28973066/adherence-to-depression-treatment-in-primary-care-a-randomized-clinical-trial
#13
Jo Anne Sirey, Samprit Banerjee, Patricia Marino, Martha L Bruce, Ashley Halkett, Molly Turnwald, Claire Chiang, Brian Liles, Amanda Artis, Fred Blow, Helen C Kales
Importance: Nonadherence to antidepressant medication is common and leads to poor outcomes. Early nonadherence is especially problematic. Objective: To test the effectiveness of a psychosocial intervention to improve early adherence among older patients whose primary care physician newly initiated an antidepressant for depression. Design, Setting, and Participants: The Treatment Initiation and Participation Program (TIP) was offered in a 2-site randomized clinical effectiveness study between January 2011 and December 2014 at primary care practices in New York, New York, and Ann Arbor, Michigan...
September 27, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28971459/scheduling-and-modeling-a-cognitive-assessment-guide-for-screening-ad-by-primary-care-physicians
#14
Maria Sagiadinou, Antigoni Avramouli, Panayiotis M Vlamos
New research data on Alzheimer's Disease define it as a clinicobiological entity, which has a long preclinical and presymptomatic phase. Emphasis has been given in early detection and diagnosis, which will allow professionals, caregivers and patients themselves to plan and adjust better to the response of the disease. Primary care physicians, who most often are the first to witness and perceive cognitive impairment, may play a central role in the diagnostic procedure, but frequently they are reluctant to be engaged to the screening procedure...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28971158/scorpion-related-cardiomyopathy-and-acute-pulmonary-edema-in-a-child-who-is-stung-by-leiurus-abdullahbayrami
#15
Mehmet Dokur, Mustafa Dogan, Ersen Aydin Yagmur
Venom of Leiurus abdullahbayrami (Scorpiones: Buthidae) is an extremely toxic one and it stimulates voltage-gated sodium and potassium channels. In case of a stung by this scorpion; excessive catecholamine release occur and it impairs left ventricle contractility and consequently a heart failure occurs (scorpion sting-related cardiomyopathy). In addition to this cardiac-induced acute pulmonary, edema may occur in severe cases too. An 11-year-old male child who was stung by a scorpion (species: Leiurus abdullahbayrami) consulted to the Emergency Room...
September 2017: Turkish Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28970332/intragastric-meal-distribution-during-gastric-emptying-scintigraphy-for-assessment-of-fundic-accommodation-correlation-with-symptoms-of-gastroparesis
#16
Perry Orthey, Daohai Yu, Mark L Van Natta, Frederick V Ramsey, Jesus R Diaz, Paige A Bennett, Andrei H Iagaru, Roberto Salas Fragomeni, Richard W McCallum, Irene Sarosiek, William L Hasler, Gianrico Farrugia, Madhusudan Grover, Kenneth L Koch, Linda Nguyen, William J Snape, Thomas L Abell, Pankaj J Pasricha, James Tonascia, Frank Hamilton, Henry P Parkman, Alan H Maurer
Impaired fundic accommodation (FA) limits fundic relaxation and ability to act as a reservoir for food. Assessing intragastric meal distribution (IMD) during gastric emptying scintigraphy (GES) allows for a simple measure of FA. GOALS: 1) Evaluate nuclear medicine and radiology physician trained readers' visual assessment of FA from solid-meal GES; 2) Develop software to quantify GES intragastric meal distribution (IMD); 3) Correlate symptoms of gastroparesis with IMD and GE. Methods: After training to achieve consensus interpretation of GES FA, 4 readers interpreted FA in 148 GES studies from normal volunteers and patients...
September 28, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28965701/environmental-exposure-to-manganese-in-air-tremor-motor-and-cognitive-symptom-profiles
#17
E S Kornblith, S L Casey, D T Lobdell, M A Colledge, R M Bowler
BACKGROUND: Excessive exposure to manganese (Mn) may cause parkinsonian-like motor and tremor symptoms and adverse cognitive effects, including problems with executive functioning (EF), resembling those found in later-stage Parkinson's disease (PD). Studies seeking to differentiate PD patients into subgroups with associated cognitive and functional outcomes using motor and tremor symptoms identified tremor-dominant (TD) and non-tremor dominant (NTD) subtypes. It is unclear whether differing patterns of pathophysiology and symptoms exist in Mn neurotoxicity, as they do in PD...
September 28, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28959482/sleep-apnoea-and-stroke
#18
REVIEW
Sameer Sharma, Antonio Culebras
Sleep disorders have been known to physicians for a long time. In his famous aphorisms, Hippocrates said "Sleep or watchfulness exceeding that which is customary, augurs unfavorably". Modern medicine has been able to disentangle some of the phenomena that disturb sleep. Among the most notable offenders is sleep apnoea that has gained prominence in the past few decades. It is being proposed as one of the potentially modifiable risk factors for vascular diseases including stroke. The pathological mechanisms linking sleep apnoea to vascular risk factors include hypoxia, cardiac arrhythmias, dysautonomia, impaired glucose tolerance, hypertension, dyslipidaemia and inflammation...
December 2016: Stroke and Vascular Neurology
https://www.readbyqxmd.com/read/28953608/the-impact-and-financial-burden-of-pulmonary-arterial-hypertension-on-patients-and-caregivers-results-from-a-national-survey
#19
Zhenguo Zhai, Xia Zhou, Shuai Zhang, Wanmu Xie, Jun Wan, Tuguang Kuang, Yuanhua Yang, Huan Huang, Chen Wang
Pulmonary arterial hypertension (PAH) is a chronic progressive devastating disease. Symptom burden might impair health-related quality of life of patients. Furthermore, treatment on this disease brings significant financial burden to patients' families. Both physiological and psychological symptoms have been reported, but limited evidence regarding the impact of PAH on patients and caregivers exists, especially the emotional issues and their association with patients' health quality. The main purpose of this study was to describe the impact of PAH on patients and their caregivers in a Chinese population...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28944220/determinants-for-further-wishes-for-cosmetic-and-reconstructive-interventions-in-1652-patients-with-surgical-treated-carcinomas-of-the-oral-cavity
#20
Henrik Holtmann, Simon Spalthoff, Nils-Claudius Gellrich, Jörg Handschel, Julian Lommen, Norbert R Kübler, Gertrud Krüskemper, Majeed Rana, Karoline Sander
BACKGROUND: The impairment of the appearance is a major problem for patients with carcinomas of the oral cavity. These patients want to recover their preoperative facial appearance. Some do not realize that this is not always possible and hence develop a desire for further cosmetic and reconstructive surgery (CRS) which often causes psychological problems. METHOD: The desire of patients for CRS (N = 410; 26%) has been acquired in this DÖSAK rehab study including multiple reasons such as medical, functional, aesthetic and psychosocial aspects...
December 2017: Maxillofacial Plastic and Reconstructive Surgery
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