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Asako Itakura, Yumiko Tani, Naoko Kaneko, Michihiro Hide
Little attention has been given to the burden of chronic urticaria (CU) in Japan compared with other skin diseases, such as atopic dermatitis (AD) and psoriasis. The primary objective of the RELEASE study was to evaluate the real-life quality-of-life impairment in CU patients in Japan. Data were collected from 1443 urticaria, 1668 AD and 435 psoriatic patients; 552 urticaria patients who presented urticaria symptoms for over 6 weeks were defined as CU. The mean Dermatology Life Quality Index (DLQI) total score was 4...
June 13, 2018: Journal of Dermatology
Marlene Elmelund, Niels Klarskov, Fin Biering-Sørensen
STUDY DESIGN: Cross-sectional study. OBJECTIVES: There is a knowledge gap on urinary incontinence in women with spinal cord injury. Hence, the aim of this study was to determine the prevalence and conditions associated with urinary incontinence in this population. SETTING: Clinic for Spinal Cord Injuries, Rigshospitalet, Denmark. METHODS: Women with a spinal cord injury between September 1999 and August 2016, who attended a consultation in our clinic during August 2010-August 2016, were included...
June 12, 2018: Spinal Cord
A Chiricozzi, V Bettoli, O De Pità, V Dini, G Fabbrocini, G Monfrecola, M L Musumeci, A Parodi, F Sampogna, A Pennella, F Buzzulini, G Gualberti, U di Luzio Paparatti, L Atzori
Hidradenitis suppurativa (HS) is a chronic relapsing inflammatory dermatosis of the body folds, characterized by nodules, abscesses, sinus tracts and numerous comorbidities, significantly impairing patients quality of life (QoL).1-5 Among skin diseases, HS has the largest impact on QoL6 . Few specific instruments are available to assess, in a comprehensive, psychosocial perspective, the burden of HS7 , and no qualitative studies exploring the experience of HS patients and their relationship with the physician are currently available...
June 12, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
Satu Turunen-Taheri, Per-Inge Carlsson, Ann-Christin Johnson, Sten Hellström
PURPOSE: The purpose of this study was to identify and report demographic data of patients with severe-to-profound hearing loss, assess participation in audiological rehabilitation and analyze the benefits of various rehabilitation methods. MATERIALS AND METHODS: Data on 4286 patients with severe-to-profound hearing impairments registered in the Swedish Quality Register of Otorhinolaryngology over a period from 2006-2015 were studied. Demographic data, gender differences, audiological rehabilitation and benefits of the rehabilitation were analyzed...
June 12, 2018: Disability and Rehabilitation
Angel A Escobedo, Pedro Almirall, Kurt Hanevik, Sérgio Cimerman, Alfonso J Rodríguez-Morales, Caridad Almanza, Jhossmar Auza-Santivañez
Although Giardia, the aetiological agent of giardiasis, is one of the most prevalent intestinal parasitic infections world-wide, for industrialised countries, it is mainly appreciated as an imported disease with the minimal local transmission. However, the current evidence challenges this perception; Giardia has relevance beyond the high prevalence areas. This infection may be asymptomatic or cause gastrointestinal complains and long-term sequelae, including irritable bowel syndrome, chronic fatigue and impaired child growth and cognitive development...
June 11, 2018: Epidemiology and Infection
Carlos Escobar, Vivencio Barrios, Luis Prieto, Jose Maria Lobos, Jose Polo, Diego Vargas, Paula Study Team
BACKGROUND: Achieving a good satisfaction with anticoagulant treatment should be a target in atrial fibrillation (AF) patients. OBJECTIVE: To ascertain the perception of patients regarding burdens and benefits of anticoagulation with vitamin K antagonists (VKA). METHODS: This was a multicenter cross-sectional/retrospective study conducted throughout Spain, in which AF patients taking VKA during the last year, attended at primary care setting were included...
June 7, 2018: Cardiovascular & Hematological Agents in Medicinal Chemistry
Deborah S Mack, Mara M Epstein, Catherine Dubé, Robin E Clark, Kate L Lapane
OBJECTIVE: United States (US) guidelines regarding when to stop routine breast cancer screening remain unclear. No national studies to-date have evaluated the use of screening mammography among US long-stay nursing home residents. This cross-sectional study was designed to identify prevalence, predictors, and geographic variation of screening mammography among that population in the context of current US guidelines. MATERIALS AND METHODS: Screening mammography prevalence, identified with Physician/Supplier Part B claims and stratified by guideline age classification (65-74, ≥75 years), was estimated for all women aged ≥65 years residing in US Medicare- and Medicaid- certified nursing homes (≥1 year) with an annual Minimum Data Set (MDS) 3...
June 4, 2018: Journal of Geriatric Oncology
De Yun Wang, Sang-Heon Cho, Horng-Chyuan Lin, Aloke Gopal Ghoshal, Abdul Razak Bin Abdul Muttalif, Sanguansak Thanaviratananich, Kaan Tunceli, Eduardo Urdaneta, Dongmu Zhang, Rab Faruqi
BACKGROUND: Allergic rhinitis (AR), asthma, chronic obstructive pulmonary disease (COPD), and rhinosinusitis are common and little studied in the Asia-Pacific region. OBJECTIVES: We sought to investigate real-world practice patterns for these respiratory diseases in India, Korea, Malaysia, Singapore, Taiwan, and Thailand. METHODS: This cross-sectional observational study enrolled adults (age ≥18 years) presenting to general practitioners (GP) or specialists for physician-diagnosed AR, asthma, COPD, or rhinosinusitis...
June 6, 2018: International Archives of Allergy and Immunology
M P Pereira, S Basta, J Moore, S Ständer
BACKGROUND: Prurigo nodularis (PN) is a chronic skin condition characterised by intensely pruritic, hyperkeratotic papulonodular lesions that dramatically impairs patients' quality of life. Management of the condition is challenging, and there is no approved therapy in the United States or in Europe. OBJECTIVE: The key aim of this survey was to examine current perceptions of PN diagnosis and management among members of the European Academy of Dermatology and Venereology (EADV)...
June 5, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
Chiara Russo, Catherine Terret, Claire Cropet, Gilles Albrand
OBJECTIVES: The management of cancer in aging people remains a challenge for physicians. Specialists agree on the assistance provided by a multidimensional geriatric assessment (MGA) to guide the cancer treatment decision-making process. We aim to explore the use of MGA in treatment decision and to identify MGA parameters likely to influence the planned cancer treatment. MATERIAL AND METHODS: We conducted a single-site retrospective study in patients older than 65 years suffering from various types of cancer who underwent MGA before cancer treatment decision...
June 1, 2018: Journal of Geriatric Oncology
Daniel T Myran, Jillian Bardsley, Tania El Hindi, Kristine Whitehead
BACKGROUND: Abortion has been decriminalized in Canada since 1988 and is considered an essential medical service. There is concern that decreasing numbers of abortion providers may impair access to abortion. This study examined the quantity of exposure and education that Canadian family medicine residents receive on abortion during training and their preparation to provide abortions. In addition, the study assessed residents' attitudes, intention and expressed competency to provide abortion in future practice and the association between medical training and changes in these factors...
June 1, 2018: BMC Medical Education
Neuza Silva, Monika Bullinger, Helena Moreira, Maria Cristina Canavarro, Carlos Carona
Most children and adolescents with chronic health conditions have impaired health-related quality of life and are at high risk of internalizing and externalizing problems. However, few patients present clinically significant symptoms. Using a decision-tree approach, this study aimed to identify risk profiles for psychological problems based on measures that can be easily scored and interpreted by healthcare professionals in pediatric settings. The participants were 736 children and adolescents between 8-18 years of age with asthma, epilepsy, cerebral palsy, type-1diabetes or obesity...
2018: PloS One
Marzena Jakimowicz-Tylicka, Michał Chmielewski, Izabella Kuźmiuk-Glembin, Piotr Skonieczny, Grażyna Dijakiewicz, Grażyna Zdrojewska, Bolesław Rutkowski, Leszek Tylicki, Alicja Dębska Ślizień
BACKGROUND: Dietary supplements (DS) are available over the counter, but patients with impaired renal function are specifically at risk for toxicity when consuming certain DS. The aim of this study was to evaluate the prevalence and characteristics of DS use in patients with chronic kidney disease (CKD). MATERIAL AND METHODS: A cross-sectional, controlled DS use survey (22 questions) was conducted among 180 CKD patients (stage 1-5, dialysis, kidney transplant), with 60 patients without CKD serving as controls...
May 30, 2018: Acta Biochimica Polonica
Qingqing Huang, Xiping Liang, Shiqiang Wang, Xiaosong Mu
Both migraine and obesity are prevalent disorders in the general population, which are characterized by disability and impaired quality of life. Although so many researches had studied the association between migraine and obesity, there are still no full knowledge of the relationship between body mass index (BMI) and migraine, especially chronic migraine (CM). In this study, we analyzed a previous epidemiological survey data of primary headache patients in Chongqing, which surveyed consecutive neurological outpatients through face-to-face interview with physicians using a headache questionnaire...
2018: Behavioural Neurology
Yuki Omori, Takashi Kanbayashi, Yohei Sagawa, Aya Imanishi, Ko Tsutsui, Yuya Takahashi, Masahiro Takeshima, Manabu Takaki, Seiji Nishino, Tetsuo Shimizu
Objectives: Delayed sleep phase syndrome (DSPS) is a chronic dysfunction of circadian rhythm of the subject that impairs functioning in social, occupational, or other spheres. High rate of depression is found among DSPS patients. Aripiprazole (APZ), a second-generation antipsychotic, is effective in treatment of depression as well as schizophrenia. Recently, few case reports show the effectiveness of APZ in treating DSPS and non-24-hour sleep-wake rhythm disorder. Therefore, we tried to treat DSPS with depression using APZ...
2018: Neuropsychiatric Disease and Treatment
Antonio Riccardo Buonomo, Emanuela Zappulo, Giulio Viceconte, Riccardo Scotto, Guglielmo Borgia, Ivan Gentile
Alemtuzumab is a monoclonal anti CD-52 antibody recently approved for use in relapsing-remitting multiple sclerosis(MS). Given that the targeted antigen is primarily expressed on B and T lymphocytes, the administration of this biological drug is associated with rapid but protracted peripheral lymphopenia. Areas covered: The impact on infective risk of this immune impairment is still to be fully understood. In this review, we attempt to summarize all the available literature concerning opportunistic infections occurring in patients with MS receiving alemtuzumab...
June 11, 2018: Expert Opinion on Drug Safety
Gustavo N Cecchino, Juan A García-Velasco
PURPOSE OF REVIEW: Surgery has traditionally been the primary treatment option for endometriosis-related infertility of any phenotype. However, advances and refinements of assisted reproductive technologies (ART) permit a more conservative approach in many scenarios. This review summarizes the latest findings in the field of reproductive medicine, which have supported a paradigm shift towards more conservative management of ovarian endometrioma. RECENT FINDINGS: The presence of ovarian endometrioma per se is likely to impair ovarian reserve and alter ovarian functional anatomy...
May 29, 2018: Current Opinion in Obstetrics & Gynecology
J J Wu, C Lin, L Sun, O Goldblum, A Zbrozek, R Burge, M Augustin, S R Feldman
BACKGROUND: The clinical meaningfulness of improvements in the Work Productivity and Activity Impairment Questionnaire for Psoriasis (WPAI-PsO) reported by patients with psoriasis in response to treatment is unknown due to the lack of any publications that report minimal clinically importance differences (MCID) for WPAI-PsO outcomes. OBJECTIVE: To determine the MCIDs for the work productivity loss and activity impairment domains of the Work Productivity and Activity Impairment Questionnaire for Psoriasis (WPAI-PsO) using results from three phase 3 trials of ixekizumab...
May 30, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
A Hajek, C Brettschneider, H van den Bussche, H Kaduszkiewicz, A Oey, B Wiese, S Weyerer, J Werle, A Fuchs, M Pentzek, J Stein, T Luck, H Bickel, E Mösch, K Heser, M Bleckwenn, M Scherer, S G Riedel-Heller, W Maier, H-H König
OBJECTIVES: The aim of this study was to identify determinants of outpatient health care utilization among the oldest old in Germany longitudinally. DESIGN: Multicenter prospective cohort "Study on Needs, health service use, costs and health-related quality of life in a large sample of oldest-old primary care patients (85+)" (AgeQualiDe). SETTING: Individuals in very old age were recruited via GP offices at six study centers in Germany...
2018: Journal of Nutrition, Health & Aging
T Rune Nielsen, Birthe Hjorth Svensson, Gitte Rohr, Hanne Gottrup, Karsten Vestergaard, Peter Høgh, Gunhild Waldemar
Background Although general recommendations for diagnostic disclosure of dementia are available, little is known about how these recommendations are implemented. The aim of the current study was to investigate the process and content of dementia diagnostic disclosure meetings, and to compare key aspects of disclosing a diagnosis of dementia and mild cognitive impairment. Method A total of 54 specialist physicians in Danish dementia diagnostic departments completed an online survey on their practices regarding diagnostic disclosure of dementia and mild cognitive impairment...
January 1, 2018: Dementia
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