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https://www.readbyqxmd.com/read/28536200/modulation-of-sensory-information-processing-by-a-neuroglobin-in-caenorhabditis-elegans
#1
Shigekazu Oda, Yu Toyoshima, Mario de Bono
Sensory receptor neurons match their dynamic range to ecologically relevant stimulus intensities. How this tuning is achieved is poorly understood in most receptors. The roundworm Caenorhabditis elegans avoids 21% O2 and hypoxia and prefers intermediate O2 concentrations. We show how this O2 preference is sculpted by the antagonistic action of a neuroglobin and an O2-binding soluble guanylate cyclase. These putative molecular O2 sensors confer a sigmoidal O2 response curve in the URX neurons that has highest slope between 15 and 19% O2 and approaches saturation when O2 reaches 21%...
June 6, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28495447/characterization-of-gene-expression-associated-with-the-adaptation-of-the-nematode-c-elegans-to-hypoxia-and-reoxygenation-stress-reveals-an-unexpected-function-of-the-neuroglobin-glb-5-in-innate-immunity
#2
Binyamin Zuckerman, Zohar Abergel, Veronica Zelmanovich, Leonor Romero, Rachel Abergel, Leonid Livshits, Yoav Smith, Einav Gross
Oxygen (O2) is a double-edged sword to cells, for while it is vital for energy production in all aerobic animals and insufficient O2 (hypoxia) can lead to cell death, the reoxygenation of hypoxic tissues may trigger the generation of reactive oxygen species (ROS) that can destroy any biological molecule. Indeed, both hypoxia and hypoxia-reoxygenation (H/R) stress are harmful, and may play a critical role in the pathophysiology of many human diseases, such as myocardial ischemia and stroke. Therefore, understanding how animals adapt to hypoxia and H/R stress is critical for developing better treatments for these diseases...
May 8, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28378164/computational-evidence-support-the-hypothesis-of-neuroglobin-also-acting-as-an-electron-transfer-species
#3
Licia Paltrinieri, Giulia Di Rocco, Gianantonio Battistuzzi, Marco Borsari, Marco Sola, Antonio Ranieri, Laura Zanetti-Polzi, Isabella Daidone, Carlo Augusto Bortolotti
Neuroglobin (Ngb) is a recently identified hexa-coordinated globin, expressed in the nervous system of humans. Its physiological role is still debated: one hypothesis is that Ngb serves as an electron transfer (ET) species, possibly by reducing cytochrome c and preventing it to initiate the apoptotic cascade. Here, we use the perturbed matrix method (PMM), a mixed quantum mechanics/molecular dynamics approach, to investigate the redox thermodynamics of two neuroglobins, namely the human Ngb and GLB-6 from invertebrate Caenorhabditis elegans...
April 4, 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/28323151/a-proteasome-inhibitor-produced-by-burkholderia-pseudomallei-modulates-intracellular-growth
#4
Sariqa Wagley, Muthita Vanaporn, Darawan Rinchai, Laura Conejero, Ganjana Lertmemongkolchai, Gregory J Bancroft, Richard W Titball
The NRPS/PKS cluster encodes the enzymes necessary for glidobactin synthesis it is partially conserved in various members of the Burkholderia genus including B. pseudomallei. In this study we have shown that the insertional inactivation or deletion of glbC in this cluster in B. pseudomallei could reduce the ability of the bacterium to survive or grow in murine macrophages or in human neutrophils. Exogenously added proteasome inhibitors were able to chemically complement the mutation. The insertional inactivation or deletion of glbC increased virulence in an acute model of infection in Balb/c or C57BL/6 mice but virulence in a chronic model of infection was similar to that of the wild type...
March 18, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28321889/antihyperglycaemic-activity-of-the-methanol-extract-from-leaves-of-eremophila-maculata-scrophulariaceae-in-streptozotocin-induced-diabetic-rats
#5
Fadia S Youssef, Mohamed L Ashour, Sherif S Ebada, Mansour Sobeh, Hesham A El-Beshbishy, Abdel Nasser Singab, Michael Wink
OBJECTIVES: This study was designed to evaluate the antihyperglycaemic activity of the methanol leaf extract of Eremophila maculata (EMM) both in vitro and in vivo. METHODS: The antihyperglycaemic activity was assessed in vitro using differentiated 3T3-L1 adipocytes, whereas in-vivo effect was evaluated in streptozotocin-induced diabetic rats. Chemical profiling of EMM was done using LC-ESI-MS techniques. Molecular modelling experiments of the identified compounds were performed using C-Docker protocol...
June 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28295436/a-systematic-review-of-gay-lesbian-and-bisexual-research-samples-in-couple-and-family-therapy-journals
#6
Erica E Hartwell, Julianne M Serovich, Sandra J Reed, Danielle Boisvert, Teresa Falbo
The purpose of this study is to review samples from research on gay, lesbian, and bisexual (GLB) issues and to evaluate the suitability of this body of research to support affirmative and evidence-based practice with GLB clients. The authors systematically reviewed the sampling methodology and sample composition of GLB-related research. All original, quantitative articles focusing on GLB issues published in couple and family therapy (CFT)-related journals since 1975 were coded (n = 153). Results suggest that within the GLB literature base there is some evidence of heterocentrism as well as neglect of issues of class, race, and gender...
March 11, 2017: Journal of Marital and Family Therapy
https://www.readbyqxmd.com/read/28284748/sexual-and-behavioral-health-disparities-among-sexual-minority-hispanics-latinos-findings-from-the-national-health-and-nutrition-examination-survey-2001-2014
#7
Omar Martinez, Ji Hyun Lee, Frank Bandiera, E Karina Santamaria, Ethan C Levine, Don Operario
INTRODUCTION: Hispanics/Latinos (henceforth, Latinos) are the largest minority group in the U.S. With growing health disparities among this group, the highest burden remains among sexual and gender minority Latinos. Differences regarding sexual orientation have not been fully explored within this group using national representative samples. This study analyzed sexual and behavioral health disparities associated with sexual minority status among Latinos in the U.S. METHODS: The study included data from 5,598 Latino adults who participated in the 2001-2014 waves of the National Health and Nutrition Examination Survey...
March 8, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28182351/increased-red-cell-distribution-width-is-strong-inflammatory-marker-of-liver-diseases-in-a-guangxi-population
#8
Fang Lan, Huiping Wei, Xuan Zhu, Shan Li, Xue Qin
BACKGROUND: Red cell distribution width (RDW), part of a routine complete blood count in a clinical laboratory, has been widely and routinely used in the diagnosis of various diseases. The aim of the present study was to investigate the relationship between increased RDW and liver diseases and whether RDW is a new inflammatory marker for liver diseases in a Guangxi population. METHODS: A total of 735 patients were enrolled in our study, including 113 patients with chronic hepatitis B (CHB), 133 liver cirrhosis (LC) patients, 105 patients with hepatocellular carcinoma (HCC), 55 alcoholic hepatitis (AH) patients, 44 chronic hepatitis C (CHC) patients, and 285 healthy persons...
February 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28009687/eus-guided-versus-percutaneous-gallbladder-drainage-isn-t-it-time-to-convert
#9
Amy Tyberg, Monica Saumoy, Enrique V Sequeiros, Marc Giovannini, Everson Artifon, Anthony Teoh, Jose Nieto, Amit P Desai, Nikhil A Kumta, Monica Gaidhane, Reem Z Sharaiha, Michel Kahaleh
BACKGROUND AND AIMS: Endoscopic ultrasound-guided drainage (EUS-GLB) is a minimally invasive option for patients with cholecystitis who are poor surgical candidates. Compared with percutaneous drainage (PC-GLB), earlier studies have demonstrated similar efficacy with improved quality of life. We present a multicenter, international experience comparing PC-GLB and EUS-GLB in nonsurgical patients with cholecystitis. METHODS: All patients who underwent either PC-GLB drainage or EUS-GLB drainage from 7 centers between January 2010 and December 2015 were included...
December 22, 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27919602/hematocrit-and-plasma-albumin-levels-difference-may-be-a-potential-biomarker-to-discriminate-preeclampsia-and-eclampsia-in-patients-with-hypertensive-disorders-of-pregnancy
#10
Dong-Mei Dai, Jing Cao, Hong-Mei Yang, Hai-Mei Sun, Yu Su, Yuan-Yuan Chen, Xiao Fang, Wang-Bin Xu
BACKGROUND: We evaluated whether alterations of hemoglobin (HB), hematocrit (HCT), serum albumin level (ALB), and the difference of HCT and ALB can be used in the diagnosis of preeclampsia and eclampsia in patients with hypertensive disorders of pregnancy (HDP). METHODS: A total of 509 individuals were recruited and divided into 4 groups: Group 1, 170 healthy non-pregnant women; Group 2, 125 normal pregnant women; Group 3, 105 pregnant women diagnosed with gestational and chronic hypertension; Group 4, 109 pregnant women diagnosed as having preeclampsia and eclampsia...
January 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/27752453/the-2015-annual-meeting-of-setac-german-language-branch-in-zurich-7-10-september-2015-ecotoxicology-and-environmental-chemistry-from-research-to-application
#11
Inge Werner, Annette Aldrich, Benjamin Becker, Dennis Becker, Markus Brinkmann, Michael Burkhardt, Norbert Caspers, Sophie Campiche, Nathalie Chèvre, Rolf-Alexander Düring, Beate I Escher, Fabian Fischer, Sabrina Giebner, Katharina Heye, Henner Hollert, Marion Junghans, Cornelia Kienle, Katja Knauer, Muris Korkaric, Veronika Märkl, Jane Muncke, Jörg Oehlmann, Georg Reifferscheid, Daniel Rensch, Andreas Schäffer, Sabrina Schiwy, Simon Schwarz, Helmut Segner, Eszter Simon, Rita Triebskorn, Etiënne L M Vermeirssen, Thomas Wintgens, Markus Zennegg
This report provides a brief review of the 20th annual meeting of the German Language Branch of the Society of Environmental Toxicology and Chemistry (SETAC GLB) held from September 7th to 10th 2015 at ETH (Swiss Technical University) in Zurich, Switzerland. The event was chaired by Inge Werner, Director of the Swiss Centre for Applied Ecotoxicology (Ecotox Centre) Eawag-EPFL, and organized by a team from Ecotox Centre, Eawag, Federal Office of the Environment, Federal Office of Agriculture, and Mesocosm GmbH (Germany)...
2016: Environmental Sciences Europe
https://www.readbyqxmd.com/read/27752452/the-german-postgraduate-degree-program-in-ecotoxicology-setac-glb-and-gdch-a-success-story
#12
EDITORIAL
Klaus Peter Ebke, Jan Ahlers, Thomas Braunbeck, Jörg Oehlmann, Toni Ratte, Ralf B Schäfer, Adolf Eisenträger, Andreas Schäffer
This article gives a comprehensive overview on the strategy, the development and the progress of the German postgraduate degree program in ecotoxicology (SETAC GLB and GDCh). The program soon prompted positive results: more than 10 years now the courses had an average enrolment rate of 90 %, and employment-seeking graduates from the first courses mostly succeeded in quickly finding employment relevant to their training. With over 450 students enrolled to date, the degree program contributes significantly to the field of Environmental Chemistry and Ecotoxicology...
2016: Environmental Sciences Europe
https://www.readbyqxmd.com/read/27739095/ceratonia-siliqua-l-immature-carob-bean-inhibits-intestinal-glucose-absorption-improves-glucose-tolerance-and-protects-against-alloxan-induced-diabetes-in-rat
#13
Kaïs Rtibi, Slimen Selmi, Dhekra Grami, Khouloud Saidani, Hichem Sebai, Mohamed Amri, Bruno Eto, Lamjed Marzouki
BACKGROUND: This study was designed to investigate the effects of immature carob pod aqueous extract (ICPAE) on intestinal glucose absorption in vitro and in vivo using an oral glucose tolerance test (OGTT) as well as the potential antidiabetic effect in alloxan-induced diabetic rats. OGTT was carried by administration of glucose (2 g kg(-1) , p.o.) and after treatment with extract (50, 100 and 200 mg kg(-1) body weight). Diabetes was induced by single intraperitoneal injection of alloxan (150 mg kg(-1) )...
October 14, 2016: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/27695650/globin-based-redox-signaling
#14
COMMENT
Sasha De Henau, Bart P Braeckman
In recent years, moderate levels of reactive oxygen species (ROS) have become recognized as signaling cues that participate at all levels of cellular organization. Globins, with their redox-active heme iron and ubiquitous presence, seem ideally suited to participate in ROS metabolism. Here we comment on our recent findings that show the participation of a globin, GLB-12, in a redox signaling pathway in Caenorhabditis elegans. We found that GLB-12 produces superoxide, a type of ROS, after which this is converted to what appears to be a hydrogen peroxide gradient over the plasma membrane by the activity of intracellular and extracellular superoxide dismutases...
2016: Worm
https://www.readbyqxmd.com/read/27608634/effect-of-dietary-protein-sources-on-production-performance-egg-quality-and-plasma-parameters-of-laying-hens
#15
Xiaocui Wang, Haijun Zhang, Hao Wang, Jing Wang, Shugeng Wu, Guanghai Qi
OBJECTIVE: This study was conducted to evaluate the effects of dietary protein sources (soybean meal, SBM; low-gossypol cottonseed meal, LCSM; double-zero rapeseed meal, DRM) on laying performance, egg quality, and plasma parameters of laying hens. METHODS: A total of 432 32-wk-old laying hens were randomly divided into 6 treatments with 6 replicates of 12 birds each. The birds were fed diets containing SBM, LCSM100, or DRM100 individually or in combination with an equal amount of crude protein (CP) (LCSM50, DRM50, and LCSM50-DRM50)...
March 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/27599793/evaluation-of-hepatorenal-impairments-in-wistar-rats-coexposed-to-low-dose-lead-cadmium-and-manganese-insights-into-oxidative-stress-mechanism
#16
Olusola Olalekan Oladipo, Joseph Olusegun Ayo, Suleiman Folorunsho Ambali, Bisalla Mohammed
The study aims to evaluate effects of chronic low-dose coexposure to lead (Pb), cadmium (Cd) and manganese (Mn) on hepatorenal toxicity and oxidative stress. Young male Wistar rats were treated with Pb acetate (1.4 mg/kg BW), Cd chloride (0.01 mg/kg BW), Mn chloride (0.14 mg/kg BW) and their combination (Pb + Cd + Mn) by oral gavage, for 15 weeks. Liver enzymes, albumin (Alb), globulin (Glb), total protein, creatinine, urea and electrolyte concentrations were measured in the serum. Hepatic and renal malondialdehyde (MDA), glutathione peroxidase-1 (GPx1) and metallothionein-1 (MT1) concentrations were measured by enzyme immunoassay technique...
November 2016: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/27431768/accessible-weight-loss-adapting-a-lifestyle-intervention-for-adults-with-impaired-mobility
#17
Andrea C Betts, Katherine Froehlich-Grobe
BACKGROUND: Despite disparities in obesity between those with and without disability, there is limited evidence to guide weight loss intervention in people with impaired mobility (IM), particularly those with severe impairments. OBJECTIVE: Examine the usability, feasibility, and effectiveness of adapting an existing evidence-based weight loss program for people with IM. METHODS: In this single-group pre-test post-test pilot study, 10 overweight or obese individuals with permanent IM (e...
January 2017: Disability and Health Journal
https://www.readbyqxmd.com/read/27338061/predictive-value-of-plasma-%C3%AE-2-microglobulin-on-human-body-function-and-senescence
#18
X-M Dong, R Cai, F Yang, Y-Y Zhang, X-G Wang, S-L Fu, J-R Zhang
OBJECTIVE: To explore the correlation between plasma β2-microglobulin (β2-MG) as senescence factor with age, heart, liver and kidney function as well as the predictive value of β2-MG in human metabolism function and senescence. PATIENTS AND METHODS: 387 cases of healthy people of different ages were selected and the automatic biochemical analyzer was used to test β2-MG in plasma based on immunoturbidimetry and also all biochemical indexes. The correlation between β2-MG and age, gender and all biochemical indexes was analyzed...
June 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27303333/best-alternatives-to-cronbach-s-alpha-reliability-in-realistic-conditions-congeneric-and-asymmetrical-measurements
#19
Italo Trizano-Hermosilla, Jesús M Alvarado
The Cronbach's alpha is the most widely used method for estimating internal consistency reliability. This procedure has proved very resistant to the passage of time, even if its limitations are well documented and although there are better options as omega coefficient or the different versions of glb, with obvious advantages especially for applied research in which the ítems differ in quality or have skewed distributions. In this paper, using Monte Carlo simulation, the performance of these reliability coefficients under a one-dimensional model is evaluated in terms of skewness and no tau-equivalence...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27105522/low-preoperative-albumin-globulin-score-predicts-favorable-survival-in-esophageal-squamous-cell-carcinoma
#20
Fei Zhang, Peng Sun, Zhi-Qiang Wang, De Shen Wang, Yun Wang, Dong-Sheng Zhang, Feng-Hua Wang, Jian-Hua Fu, Rui-Hua Xu, Yu-Hong Li
This study retrospectively investigated the prognostic significance of the preoperative albumin-globulin score (AGS) and albumin/globulin ratio (AGR) in esophageal squamous cell carcinoma (ESCC). A cohort of 458 newly diagnosed ESCC patients who underwent radical esophagectomy in Sun Yat-sen University Cancer Center (Guangzhou, China) between January 2006 and December 2010 were selected into this study. The optimal cut-off value was identified to be 45.6 g/L, 26.9 g/L and 1.30 for albumin (ALB), globulin (GLB) and AGR in terms of survival, respectively...
May 24, 2016: Oncotarget
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