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https://www.readbyqxmd.com/read/28707744/the-impact-of-molecular-subtype-on-breast-cancer-recurrence-in-young-women-treated-with-contemporary-adjuvant-therapy
#1
Hanan Alabdulkareem, Tiffany Pinchinat, Sarah Khan, Alyssa Landers, Paul Christos, Rache Simmons, Tracy-Ann Moo
Breast cancer is the leading cause of cancer death in women younger than 40 years. Triple-negative breast cancer (TNBC) and human epidermal growth factor receptor-2 (HER2) positive subtypes have a particularly poor prognosis in this age group. The purpose of this study was to compare rates of recurrence among breast cancer subtypes in young patients treated with modern adjuvant systemic therapy. A retrospective review of breast cancer patients managed at a major academic breast center between May 2000 and November 2014 was performed...
July 14, 2017: Breast Journal
https://www.readbyqxmd.com/read/28612228/pleomorphic-lobular-carcinoma-in-situ-of-the-breast-a-single-institution-experience-with-clinical-follow-up-and-centralized-pathology-review
#2
Marina De Brot, Starr Koslow Mautner, Shirin Muhsen, Victor P Andrade, Anita Mamtani, Melissa Murray, Dilip Giri, Rita A Sakr, Edi Brogi, Tari A King
PURPOSE: The natural history of pleomorphic lobular carcinoma in situ (PLCIS) remains largely unknown. METHODS: A pathology database search (1995-2012) was performed to identify patients diagnosed with an LCIS variant. Patients with synchronous breast cancer and/or no evidence of pleomorphism were excluded. Original slides were re-evaluated by three pathologists to identify a consensus cohort of PLCIS. Borderline lesions with focal atypia were classified as LCIS with pleomorphic features (LCIS-PF)...
June 13, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28358936/association-of-radiotherapy-boost-for-ductal-carcinoma-in-situ-with-local-control-after-whole-breast-radiotherapy
#3
Meena S Moran, Yinjun Zhao, Shuangge Ma, Youlia Kirova, Alain Fourquet, Peter Chen, Karen Hoffman, Kelly Hunt, Julia Wong, Lia M Halasz, Gary Freedman, Robert Prosnitz, Michael Yassa, David H A Nguyen, Tarek Hijal, Bruce G Haffty, Elaine S Wai, Pauline T Truong
Importance: The use of a radiotherapy (RT) boost to the tumor bed after whole-breast RT (WBRT) for ductal carcinoma in situ (DCIS) is largely extrapolated from invasive cancer data, but robust evidence specific to DCIS is lacking. Objective: To compare ipsilateral breast tumor recurrence (IBTR) in women with DCIS treated with vs without the RT boost after breast-conserving surgery and WBRT. Design, Setting, and Participants: This retrospective analysis pooled deidentified patient-level data from 10 academic institutions in the United States, Canada, and France from January 1, 1980, through December 31, 2010...
March 30, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28285968/histologic-factors-predicting-invasion-in-patients-with-ductal-carcinoma-in-situ-dcis-in-the-preoperative-core-biopsy
#4
Areej M Al Nemer
BACKGROUND: It is desirable to decrease the underestimation rate of invasion in cases diagnosed as ductal carcinoma in situ (DCIS) in breast core needle biopsy (CNB) in order to determine the appropriate candidates for axillary staging. The objective of this study is to identify the predictors of invasion in histology. METHODS AND RESULTS: Consecutive 92 CNB's were retrospectively evaluated. The upstaging rate was 47.8% after surgery. Among all the evaluated parameters, high nuclear grade, single architectural pattern, marked periductal lymphocytic infiltration, partial myoepithelial loss and the presence of foci suspicious of microinvasion were the significant predictors of invasion (two tailed p values 0...
May 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28133213/-a-case-of-recurrent-breast-cancer-with-adrenal-metastasis-resected-using-laparoscopic-surgery
#5
Hirotomo Murakami, Yoko Ohtani, Tatsuya Kinoshita, Kiyo Tanaka, Hiroyuki Yasojima, Makiko Mizutani, Shoji Nakamori, Mitsugu Sekimoto, Kiyoshi Mori, Masayuki Mano, Norikazu Masuda
We report a case of recurrent breast cancer with involvement of the right adrenal grand, which was resected using laparoscopic surgery. The patient was a 41-year-old woman who underwent duct-lobular segmentectomy for ductal carcinoma in situ. Histopathology showed microinvasion, and tested positive for ER and PR, but negative for HER2, so we applied radiation to the remaining breast and administered tamoxifen. After 9 months, local recurrence was detected and quadrantectomy with axillary lymph node dissection was performed...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133021/-breast-cancer-with-microinvasion-and-lymph-node-metastasis-diagnosed-by-microdochectomy-report-of-a-case
#6
Kenichi Sakurai, Shigeru Fujisaki, Keita Adachi, Shuhei Suzuki, Yuki Masuo, Saki Nagashima, Yukiko Hara, Tomohiro Hirano, Katsuhisa Enomoto, Ryouichi Tomita, Kenji Gonda
We report a case of breast cancer with microinvasion and lymph node metastasis. The patient was a 72-year-old woman who had spontaneous nipple discharge from her left breast. There was no detectable lesion on mammographyor duct endoscopy. Ultrasonography showed a low echoic lesion, 23×15mm in diameter, in the CD area of her left breast. Contrastenhanced MRI showed a high intensityarea, 25mm in diameter, in her left breast, so microdochectomywas performed. The histopathological diagnosis was invasive ductal carcinoma(invasion of 2mm)and the surgical margin was positive...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/27959581/quality-assurance-in-breast-pathology-lessons-learned-from-a-review-of-amended-reports
#7
REVIEW
Beth T Harrison, Deborah A Dillon, Andrea L Richardson, Jane E Brock, Anthony J Guidi, Susan C Lester
CONTEXT: -A review of amended pathology reports provides valuable information regarding defects in the surgical pathology process. OBJECTIVE: -To review amended breast pathology reports with emphasis placed on interpretative errors and their mechanisms of detection. DESIGN: -All amended pathology reports for breast surgical specimens for a 5-year period at a large academic medical center were retrospectively identified and classified based on an established taxonomy...
February 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/27692774/can-sentinel-lymph-node-biopsy-be-spared-in-papillary-carcinoma-of-the-breast
#8
Yihong Wang, Shaolei Lu, Theresa Graves, Madhu M Ouseph, Murray B Resnick, Evgeny Yakirevich
BACKGROUND: Papillary carcinoma (PC) of the breast represents ∼0.5% of all newly diagnosed cases of breast cancer and usually has an indolent course. The current data suggest lack of a consensus in the surgical management of this disease. Because patients can occasionally develop metastatic disease, sentinel lymph node (SLN) biopsy is often performed during surgery. MATERIALS AND METHODS: In the present study, we retrospectively evaluated the histologic characteristics of 99 cases of PC with or without associated frank invasive carcinoma, including 43 encapsulated or intracystic PCs, 24 solid PCs, and 32 intraductal PCs, and correlated these with the incidence of nodal metastasis...
April 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/27618803/sensitivity-of-breast-mri-for-ductal-carcinoma-in-situ-appearing-as-microcalcifications-only-on-mammography
#9
Pierluigi Rinaldi, Chiara Buccheri, Michela Giuliani, Enida Bufi, Maurizio Romani, Federica Patrolecco, Paolo Belli, Lorenzo Bonomo
PURPOSE: This study aims to investigate sensitivity of breast magnetic resonance imaging (MRI) for mammographic microcalcifications-only ductal carcinoma in situ (DCIS), based on its histopathology and mammographic extent of microcalcifications. METHODS: Mammograms were reviewed to measure the extent of microcalcifications. Sensitivity of MRI was calculated in the overall study population and in groups differing for DCIS nuclear grade, microinvasivity, and microcalcifications' extent...
November 2016: Clinical Imaging
https://www.readbyqxmd.com/read/27577080/biologic-behavior-and-long-term-outcomes-of-breast-ductal-carcinoma-in-situ-with-microinvasion
#10
Yan Fang, Jiayi Wu, Wei Wang, Xiaochun Fei, Yu Zong, Xiaosong Chen, Ou Huang, Jianrong He, Weiguo Chen, Yafen Li, Kunwei Shen, Li Zhu
BACKGROUND: Ductal carcinoma in situ with microinvasion (DCIS-Mi) generally has favorable prognosis, but the long-term outcomes of DCIS-Mi and the biologic evolution from ductal carcinoma in situ (DCIS), DCIS-Mi, to DCIS with T1a breast cancer (DCIS-T1a) has not been specified. The aim of our study was to explore the biological and prognostic features of DCIS-Mi, compared with pure DCIS and DCIS-T1a. RESULTS: After a median follow-up of 31 months, the 3-year estimated disease free survival(DFS) rate of DCIS-Mi patients was significantly lower than that of pure DCIS patients (89...
September 27, 2016: Oncotarget
https://www.readbyqxmd.com/read/27406051/review-of-the-national-external-quality-assessment-eqa-scheme-for-breast-pathology-in-the-uk
#11
Emad A Rakha, Rachel L Bennett, Derek Coleman, Sarah E Pinder, Ian O Ellis
BACKGROUND: The National Health Service Breast Screening Programme (NHSBSP; pathology) external quality assurance (EQA) scheme aims to provide a mechanism for examination and monitoring of concordance of pathology reporting within the UK. This study aims to review the breast EQA scheme performance data collected over a 24-year period following its introduction. METHODS: Data on circulations, number of cases and diagnosis were collected. Detailed analyses with and without combinations of certain diagnostic entities, and over different time periods were performed...
January 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/27402610/an-examination-of-the-local-cellular-immune-response-to-examples-of-both-ductal-carcinoma-in-situ-dcis-of-the-breast-and-dcis-with-microinvasion-with-emphasis-on-tertiary-lymphoid-structures-and-tumor-infiltrating-lymphoctytes
#12
Ahrong Kim, Sun-Hee Heo, Young-Ae Kim, Gyungyub Gong, Hee Jin Lee
OBJECTIVES: We tried to describe cellular immune response (tertiary lymphoid structures (TLSs), lymphoid aggregates, tumor infiltrating lymphocytes (TILs)) in neoplastic microenvironment of ductal carcinoma in situ (DCIS) with or without associated microinvasion. METHODS: The histopathologic parameters of 177 DCIS and 27 DCIS with microinvasion were evaluated. We determined number of ducts involved by DCIS, and calculated percentage of these ducts surrounded by TLSs...
July 2016: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/27334212/utilization-of-axillary-surgery-for-patients-with-ductal-carcinoma-in-situ-a-report-from-the-national-cancer-data-base
#13
Megan E Miller, Alexandra Kyrillos, Katharine Yao, Olga Kantor, Jennifer Tseng, David J Winchester, Lawrence N Shulman
BACKGROUND: This study evaluated the use of axillary surgery (AS), including sentinel lymph node biopsy (SLNB), for patients with ductal carcinoma in situ (DCIS) and the factors associated with its use. To determine whether utilization of SLNB is appropriate, predictors of SLNB performance were compared with factors predictive of tumor upstaging. METHODS: The National Cancer Data Base was utilized to identify patients with American Joint Committee on Cancer (AJCC) clinical stage 0 breast cancer treated from 2004 to 2013...
October 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27312540/ductal-carcinoma-in-situ-and-ductal-carcinoma-in-situ-with-microinvasion-correlation-of-fdg-uptake-with-histological-and-biological-prognostic-factors
#14
Ye Young Seo, Ie Ryung Yoo, Sonya Youngju Park, Jin Kyoung Oh, Sung Hoon Kim, Hyung Sun Sohn
BACKGROUND: Several studies investigated the correlation between the intensity of fluorodeoxyglucose (FDG) uptake and some histological and biological characteristics in breast cancer. Ductal carcinoma in situ (DCIS) is generally thought to be a precursor lesion of invasive breast cancer. The aim of this study was to assess the correlation between FDG uptake values on positron emission tomography/computed tomography (PET/CT) with histological and biological prognostic factors in DCIS and ductal carcinoma in situ with microinvasion (DCIS-Mi)...
May 2017: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/27279686/diagnostic-pitfall-in-a-case-of-ductal-carcinoma-in-situ-with-microinvasion
#15
Yasmin A Momin, Medha P Kulkarni, Bhakti D Deshmukh, Kalpana R Sulhyan
We report a case of microinvasive carcinoma of the breast cytologically diagnosed as ductal carcinoma - in situ in an 80-year-old lady with a breast lump. Extensive sampling of mastectomy specimen showed ductal carcinoma in situ (DCIS). Many ducts showed stromal reaction - periductal sclerosis and lymphocytic infiltration-features suggestive of microinvasion. However, no definite invasion was noted histologically. Immunohistochemical study highlighted the microinvasive foci.
April 2016: Journal of Cytology
https://www.readbyqxmd.com/read/27207096/should-new-no-ink-on-tumor-lumpectomy-margin-guidelines-be-applied-to-ductal-carcinoma-in-situ-dcis-a-retrospective-review-using-shaved-cavity-margins
#16
Andrea L Merrill, Rong Tang, Jennifer K Plichta, Upahvan Rai, Suzanne B Coopey, Maureen P McEvoy, Kevin S Hughes, Michelle C Specht, Michele A Gadd, Barbara L Smith
BACKGROUND: No consensus exists for clear margins for breast-conserving surgery for pure ductal carcinoma in situ (DCIS). We examined the implications of applying a "no ink on tumor" standard for pure DCIS by correlating clear margin width with rates of residual disease. METHODS: Lumpectomies with complete shaved cavity margins (SCMs) for pure DCIS at our institution from 2004 to 2007 were reviewed and patients with microinvasive cancer or multifocal disease requiring multiple wires excluded...
October 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27081649/sentinel-lymph-node-biopsy-in-clinically-detected-ductal-carcinoma-in-situ
#17
Ahmed Yahia Al-Ameer, Sahar Al Nefaie, Badria Al Johani, Ihab Anwar, Taher Al Tweigeri, Asma Tulbah, Mohmmed Alshabanah, Osama Al Malik
AIM: To study the indications for sentinel lymph node biopsy (SLNB) in clinically-detected ductal carcinoma in situ (CD-DCIS). METHODS: A retrospective analysis of 20 patients with an initial diagnosis of pure DCIS by an image-guided core needle biopsy (CNB) between June 2006 and June 2012 was conducted at King Faisal Specialist Hospital. The accuracy of performing SLNB in CD-DCIS, the rate of sentinel and non-sentinel nodal metastasis, and the histologic underestimation rate of invasive cancer at initial diagnosis were analyzed...
April 10, 2016: World Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27067690/-a-case-of-glycogen-rich-clear-cell-carcinoma-of-the-breast-with-extensive-intraductal-components-and-micrometastases-to-the-axillary-lymph-node
#18
Hirohito Seki, Kenichi Sasaki, Shojiro Morinaga, Fumiki Asanuma, Hisashi Yanaihara, Munehisa Kaneda, Keiichi Suzuki, Yoshiyuki Ishii, Noriki Kamiya, Masayoshi Osaku, Tadashi Ikeda
A 48-year-old woman had a left breast mass identified during routine breast cancer screening. The mammogram showed pleomorphic-segmental microcalcifications in the mediolateral-oblique view of the left breast. Ultrasonography showed a hypoechoic mass approximately 3.7 cm in diameter with multiple calcifications. Contrast-enhanced magnetic resonance imaging of the breast showed non-mass like enhancement of approximately 4 cm in diameter in the C area of the left breast. She was diagnosed with glycogen-rich clear cell carcinoma (GRCC) by ultrasound-guided vacuum-assisted biopsy...
February 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/27030304/two-progressive-pathways-of-microinvasive-carcinoma-low-grade-luminal-pathway-and-high-grade-her2-pathway-based-on-high-tumour-infiltrating-lymphocytes
#19
Michi Morita, Rin Yamaguchi, Maki Tanaka, Gary M Tse, Miki Yamaguchi, Hiroko Otsuka, Naoki Kanomata, Shigeki Minami, Susumu Eguchi, Hirohisa Yano
AIMS: While cancer immunity is involved in tumour progression from the very early stage, no detailed study has been reported on the relationship between 'early-stage' breast cancer and tumour-infiltrating lymphocytes (TILs). We focused on microinvasive carcinoma to investigate the relationship between histological tumour factors and immunity in 'early' breast cancer. METHODS: Of 2593 resected breast carcinomas, 46 microinvasive carcinomas (1.8%) were included. The relationships between tumour characteristics (invasive form, grade, comedo, subtype) and immunological characteristics (TIL, healing) were examined...
October 2016: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/27029367/-analysis-of-the-reported-data-of-national-rural-cervical-cancer-screening-project-from-2012-to-2013-china
#20
X M Luo, L Song, J L Wu, Y Liu, J L Di, B Song, R M Zheng, L Ma
OBJECTIVE: To analyze the reported data of national rural cervical cancer screening project from 2012 to 2013 and to evaluate the project implementation condition. METHODS: Data of the national breast carcinoma and cervical cancer (two-cancer) screening project for rural women were collected from the online report system of key women and children's public health service programs.The screening items included: preliminary screening of cervical lesions (cervical cytology, using Traian Bethesda System(TBS) or Pap grading for classification and reporting), acetate/iodide staining (VIA/VILI), colposcopy, histopathological examination, and pathological diagnosis...
April 2016: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
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