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Microinvasive breast carcinoma

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https://www.readbyqxmd.com/read/27692774/can-sentinel-lymph-node-biopsy-be-spared-in-papillary-carcinoma-of-the-breast
#1
Yihong Wang, Shaolei Lu, Theresa Graves, Madhu M Ouseph, Murray B Resnick, Evgeny Yakirevich
BACKGROUND: Papillary carcinoma (PC) of the breast represents ∼0.5% of all newly diagnosed cases of breast cancer and usually has an indolent course. The current data suggest lack of a consensus in the surgical management of this disease. Because patients can occasionally develop metastatic disease, sentinel lymph node (SLN) biopsy is often performed during surgery. MATERIALS AND METHODS: In the present study, we retrospectively evaluated the histologic characteristics of 99 cases of PC with or without associated frank invasive carcinoma, including 43 encapsulated or intracystic PCs, 24 solid PCs, and 32 intraductal PCs, and correlated these with the incidence of nodal metastasis...
September 8, 2016: Clinical Breast Cancer
https://www.readbyqxmd.com/read/27618803/sensitivity-of-breast-mri-for-ductal-carcinoma-in-situ-appearing-as-microcalcifications-only-on-mammography
#2
Pierluigi Rinaldi, Chiara Buccheri, Michela Giuliani, Enida Bufi, Maurizio Romani, Federica Patrolecco, Paolo Belli, Lorenzo Bonomo
PURPOSE: This study aims to investigate sensitivity of breast magnetic resonance imaging (MRI) for mammographic microcalcifications-only ductal carcinoma in situ (DCIS), based on its histopathology and mammographic extent of microcalcifications. METHODS: Mammograms were reviewed to measure the extent of microcalcifications. Sensitivity of MRI was calculated in the overall study population and in groups differing for DCIS nuclear grade, microinvasivity, and microcalcifications' extent...
August 6, 2016: Clinical Imaging
https://www.readbyqxmd.com/read/27577080/biologic-behavior-and-long-term-outcomes-of-breast-ductal-carcinoma-in-situ-with-microinvasion
#3
Yan Fang, Jiayi Wu, Wei Wang, Xiaochun Fei, Yu Zong, Xiaosong Chen, Ou Huang, Jianrong He, Weiguo Chen, Yafen Li, Kunwei Shen, Li Zhu
BACKGROUND: Ductal carcinoma in situ with microinvasion (DCIS-Mi) generally has favorable prognosis, but the long-term outcomes of DCIS-Mi and the biologic evolution from ductal carcinoma in situ (DCIS), DCIS-Mi, to DCIS with T1a breast cancer (DCIS-T1a) has not been specified. The aim of our study was to explore the biological and prognostic features of DCIS-Mi, compared with pure DCIS and DCIS-T1a. RESULTS: After a median follow-up of 31 months, the 3-year estimated disease free survival(DFS) rate of DCIS-Mi patients was significantly lower than that of pure DCIS patients (89...
August 26, 2016: Oncotarget
https://www.readbyqxmd.com/read/27406051/review-of-the-national-external-quality-assessment-eqa-scheme-for-breast-pathology-in-the-uk
#4
Emad A Rakha, Rachel L Bennett, Derek Coleman, Sarah E Pinder, Ian O Ellis
BACKGROUND: The National Health Service Breast Screening Programme (NHSBSP; pathology) external quality assurance (EQA) scheme aims to provide a mechanism for examination and monitoring of concordance of pathology reporting within the UK. This study aims to review the breast EQA scheme performance data collected over a 24-year period following its introduction. METHODS: Data on circulations, number of cases and diagnosis were collected. Detailed analyses with and without combinations of certain diagnostic entities, and over different time periods were performed...
July 12, 2016: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/27402610/an-examination-of-the-local-cellular-immune-response-to-examples-of-both-ductal-carcinoma-in-situ-dcis-of-the-breast-and-dcis-with-microinvasion-with-emphasis-on-tertiary-lymphoid-structures-and-tumor-infiltrating-lymphoctytes
#5
Ahrong Kim, Sun-Hee Heo, Young-Ae Kim, Gyungyub Gong, Hee Jin Lee
OBJECTIVES: We tried to describe cellular immune response (tertiary lymphoid structures (TLSs), lymphoid aggregates, tumor infiltrating lymphocytes (TILs)) in neoplastic microenvironment of ductal carcinoma in situ (DCIS) with or without associated microinvasion. METHODS: The histopathologic parameters of 177 DCIS and 27 DCIS with microinvasion were evaluated. We determined number of ducts involved by DCIS, and calculated percentage of these ducts surrounded by TLSs...
July 2016: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/27334212/utilization-of-axillary-surgery-for-patients-with-ductal-carcinoma-in-situ-a-report-from-the-national-cancer-data-base
#6
Megan E Miller, Alexandra Kyrillos, Katharine Yao, Olga Kantor, Jennifer Tseng, David J Winchester, Lawrence N Shulman
BACKGROUND: This study evaluated the use of axillary surgery (AS), including sentinel lymph node biopsy (SLNB), for patients with ductal carcinoma in situ (DCIS) and the factors associated with its use. To determine whether utilization of SLNB is appropriate, predictors of SLNB performance were compared with factors predictive of tumor upstaging. METHODS: The National Cancer Data Base was utilized to identify patients with American Joint Committee on Cancer (AJCC) clinical stage 0 breast cancer treated from 2004 to 2013...
October 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27312540/ductal-carcinoma-in-situ-and-ductal-carcinoma-in-situ-with-microinvasion-correlation-of-fdg-uptake-with-histological-and-biological-prognostic-factors
#7
Ye Young Seo, Ie Ryung Yoo, Sonya Youngju Park, Jin Kyoung Oh, Sung Hoon Kim, Hyung Sun Sohn
BACKGROUND: Several studies investigated the correlation between the intensity of fluorodeoxyglucose (FDG) uptake and some histological and biological characteristics in breast cancer. Ductal carcinoma in situ (DCIS) is generally thought to be a precursor lesion of invasive breast cancer. The aim of this study was to assess the correlation between FDG uptake values on positron emission tomography/computed tomography (PET/CT) with histological and biological prognostic factors in DCIS and ductal carcinoma in situ with microinvasion (DCIS-Mi)...
June 16, 2016: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/27279686/diagnostic-pitfall-in-a-case-of-ductal-carcinoma-in-situ-with-microinvasion
#8
Yasmin A Momin, Medha P Kulkarni, Bhakti D Deshmukh, Kalpana R Sulhyan
We report a case of microinvasive carcinoma of the breast cytologically diagnosed as ductal carcinoma - in situ in an 80-year-old lady with a breast lump. Extensive sampling of mastectomy specimen showed ductal carcinoma in situ (DCIS). Many ducts showed stromal reaction - periductal sclerosis and lymphocytic infiltration-features suggestive of microinvasion. However, no definite invasion was noted histologically. Immunohistochemical study highlighted the microinvasive foci.
April 2016: Journal of Cytology
https://www.readbyqxmd.com/read/27207096/should-new-no-ink-on-tumor-lumpectomy-margin-guidelines-be-applied-to-ductal-carcinoma-in-situ-dcis-a-retrospective-review-using-shaved-cavity-margins
#9
Andrea L Merrill, Rong Tang, Jennifer K Plichta, Upahvan Rai, Suzanne B Coopey, Maureen P McEvoy, Kevin S Hughes, Michelle C Specht, Michele A Gadd, Barbara L Smith
BACKGROUND: No consensus exists for clear margins for breast-conserving surgery for pure ductal carcinoma in situ (DCIS). We examined the implications of applying a "no ink on tumor" standard for pure DCIS by correlating clear margin width with rates of residual disease. METHODS: Lumpectomies with complete shaved cavity margins (SCMs) for pure DCIS at our institution from 2004 to 2007 were reviewed and patients with microinvasive cancer or multifocal disease requiring multiple wires excluded...
October 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27081649/sentinel-lymph-node-biopsy-in-clinically-detected-ductal-carcinoma-in-situ
#10
Ahmed Yahia Al-Ameer, Sahar Al Nefaie, Badria Al Johani, Ihab Anwar, Taher Al Tweigeri, Asma Tulbah, Mohmmed Alshabanah, Osama Al Malik
AIM: To study the indications for sentinel lymph node biopsy (SLNB) in clinically-detected ductal carcinoma in situ (CD-DCIS). METHODS: A retrospective analysis of 20 patients with an initial diagnosis of pure DCIS by an image-guided core needle biopsy (CNB) between June 2006 and June 2012 was conducted at King Faisal Specialist Hospital. The accuracy of performing SLNB in CD-DCIS, the rate of sentinel and non-sentinel nodal metastasis, and the histologic underestimation rate of invasive cancer at initial diagnosis were analyzed...
April 10, 2016: World Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27067690/-a-case-of-glycogen-rich-clear-cell-carcinoma-of-the-breast-with-extensive-intraductal-components-and-micrometastases-to-the-axillary-lymph-node
#11
Hirohito Seki, Kenichi Sasaki, Shojiro Morinaga, Fumiki Asanuma, Hisashi Yanaihara, Munehisa Kaneda, Keiichi Suzuki, Yoshiyuki Ishii, Noriki Kamiya, Masayoshi Osaku, Tadashi Ikeda
A 48-year-old woman had a left breast mass identified during routine breast cancer screening. The mammogram showed pleomorphic-segmental microcalcifications in the mediolateral-oblique view of the left breast. Ultrasonography showed a hypoechoic mass approximately 3.7 cm in diameter with multiple calcifications. Contrast-enhanced magnetic resonance imaging of the breast showed non-mass like enhancement of approximately 4 cm in diameter in the C area of the left breast. She was diagnosed with glycogen-rich clear cell carcinoma (GRCC) by ultrasound-guided vacuum-assisted biopsy...
February 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/27030304/two-progressive-pathways-of-microinvasive-carcinoma-low-grade-luminal-pathway-and-high-grade-her2-pathway-based-on-high-tumour-infiltrating-lymphocytes
#12
Michi Morita, Rin Yamaguchi, Maki Tanaka, Gary M Tse, Miki Yamaguchi, Hiroko Otsuka, Naoki Kanomata, Shigeki Minami, Susumu Eguchi, Hirohisa Yano
AIMS: While cancer immunity is involved in tumour progression from the very early stage, no detailed study has been reported on the relationship between 'early-stage' breast cancer and tumour-infiltrating lymphocytes (TILs). We focused on microinvasive carcinoma to investigate the relationship between histological tumour factors and immunity in 'early' breast cancer. METHODS: Of 2593 resected breast carcinomas, 46 microinvasive carcinomas (1.8%) were included. The relationships between tumour characteristics (invasive form, grade, comedo, subtype) and immunological characteristics (TIL, healing) were examined...
October 2016: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/27029367/-analysis-of-the-reported-data-of-national-rural-cervical-cancer-screening-project-from-2012-to-2013-china
#13
X M Luo, L Song, J L Wu, Y Liu, J L Di, B Song, R M Zheng, L Ma
OBJECTIVE: To analyze the reported data of national rural cervical cancer screening project from 2012 to 2013 and to evaluate the project implementation condition. METHODS: Data of the national breast carcinoma and cervical cancer (two-cancer) screening project for rural women were collected from the online report system of key women and children's public health service programs.The screening items included: preliminary screening of cervical lesions (cervical cytology, using Traian Bethesda System(TBS) or Pap grading for classification and reporting), acetate/iodide staining (VIA/VILI), colposcopy, histopathological examination, and pathological diagnosis...
April 2016: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/26818833/consistency-in-recognizing-microinvasion-in-breast-carcinomas-is-improved-by-immunohistochemistry-for-myoepithelial-markers
#14
G Cserni, C A Wells, H Kaya, P Regitnig, A Sapino, G Floris, T Decker, M P Foschini, P J van Diest, D Grabau, A Reiner, J DeGaetano, E Chmielik, A Cordoba, X Andreu, V Zolota, E Charafe-Jauffret, A Ryska, Z Varga, N Weingertner, J P Bellocq, I Liepniece-Karele, G Callagy, J Kulka, H Bürger, P Figueiredo, J Wesseling, I Amendoeira, D Faverly, C M Quinn, S Bianchi
Microinvasion is the smallest morphologically identifiable stage of invasion. Its presence and distinction from in situ carcinoma may have therapeutic implications, and clinical staging also requires the recognition of this phenomenon. Microinvasion is established on the basis of several morphological criteria, which may be difficult and not perfectly reproducible among pathologists. The aim of this study was to assess the consistency of diagnosing microinvasion in the breast on traditional haematoxylin and eosin (HE) stained slides and to evaluate whether immunohistochemistry (IHC) for myoepithelial markers could improve this...
April 2016: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/26622778/sentinel-lymph-node-biopsy-in-patients-with-breast-ductal-carcinoma-in-situ-chinese-experiences
#15
Xiao Sun, Hao Li, Yan-Bing Liu, Zheng-Bo Zhou, Peng Chen, Tong Zhao, Chun-Jian Wang, Zhao-Peng Zhang, Peng-Fei Qiu, Yong-Sheng Wang
The axillary treatment of patients with ductal carcinoma in situ (DCIS) remains controversial. The aim of the present study was to evaluate the roles of sentinel lymph node biopsy (SLNB) in patients with breast DCIS. A database containing the data from 262 patients diagnosed with breast DCIS and 100 patients diagnosed with DCIS with microinvasion (DCISM) who received SLNB between January 2002 and July 2014 was retrospectively analyzed. Of the 262 patients with DCIS, 9 presented with SLN metastases (3 macrometastases and 6 micrometastases)...
September 2015: Oncology Letters
https://www.readbyqxmd.com/read/26509833/predictive-factors-for-invasive-cancer-in-surgical-specimens-following-an-initial-diagnosis-of-ductal-carcinoma-in-situ-after-stereotactic-vacuum-assisted-breast-biopsy-in-microcalcification-only-lesions
#16
Hatice Gümüş, Philippa Mills, David Fish, Metehan Gümüş, Karina Cox, Haresh Devalia, Sue Jones, Peter Jones, Ali R Sever
PURPOSE: The aim of this study was to determine the incidence of invasive breast carcinoma in patients with preoperative diagnosis of ductal carcinoma in situ (DCIS) by stereotactic vacuum-assisted biopsy (SVAB) performed for microcalcification-only lesions, and to identify the predictive factors of invasion. METHODS: From 2000 to 2010, the records of 353 DCIS patients presenting with microcalcification-only lesions who underwent SVAB were retrospectively reviewed...
January 2016: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/26324758/sonographic-features-of-ductal-carcinoma-in-situ-of-the-breast-with-microinvasion-correlation-with-clinicopathologic-findings-and-biomarkers
#17
COMPARATIVE STUDY
Jie-Jie Yao, Wei-Wei Zhan, Man Chen, Xiao-Xiao Zhang, Ying Zhu, Xiao-Chun Fei, Xiao-Song Chen
OBJECTIVES: To compare the sonographic results, clinicopathologic characteristics, and biomarkers in pure ductal carcinoma in situ (DCIS) of the breast and DCIS with microinvasion. METHODS: A total of 218 patients with pathologically proven DCIS based on sonography in our hospital (2009-2013) were retrospectively enrolled. Clinicopathologic characteristics and biomarkers were examined. Grayscale sonographic results were investigated according to the American College of Radiology Breast Imaging Reporting and Data System lexicon, and color Doppler sonography was used to assess the vascularization distribution and degree...
October 2015: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/26314790/radiotherapy-after-mastectomy-for-screen-detected-ductal-carcinoma-in-situ
#18
K Clements, D Dodwell, G Lawrence, G Ball, A Francis, S Pinder, E Sawyer, M Wallis, A M Thompson
BACKGROUND: A role for radiotherapy after mastectomy for ductal carcinoma in situ (DCIS) is unclear. Using a prospective audit of DCIS detected through the NHS Breast Screening Programme we sought to determine a rationale for the use of post mastectomy radiotherapy for DCIS. METHODS: Over a nine year period, from 9972 patients with screen-detected DCIS and complete surgical, pathology, radiotherapy and follow up data, 2944 women underwent mastectomy for DCIS of whom 33 (1...
October 2015: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/26089220/acr-appropriateness-criteria%C3%A2-ductal-carcinoma-in-situ
#19
REVIEW
Seth A Kaufman, Eleanor E R Harris, Lisa Bailey, Manjeet Chadha, Sharon C Dutton, Gary M Freedman, Sharad Goyal, Michele Y Halyard, Kathleen C Horst, Kristina L M Novick, Catherine C Park, W Warren Suh, Deborah Toppmeyer, Jennifer Zook, Bruce G Haffty
Ductal carcinoma in situ (DCIS) is a breast neoplasm with potential for progression to invasive cancer. Management commonly involves excision, radiotherapy, and hormonal therapy. Surgical assessment of regional lymph nodes is rarely indicated except in cases of microinvasion or mastectomy. Radiotherapy is employed for local control in breast conservation, although it may be omitted for select low-risk situations. Several radiotherapy techniques exist beyond standard whole-breast irradiation (ie, partial-breast irradiation [PBI], hypofractionated whole-breast radiation); evidence for these is evolving...
June 2015: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/26063655/intratumoral-metabolic-heterogeneity-predicts-invasive-components-in-breast-ductal-carcinoma-in-situ
#20
Hai-Jeon Yoon, Yemi Kim, Bom Sahn Kim
OBJECTIVES: This study investigated whether texture-based imaging parameters could identify invasive components of ductal carcinoma in situ (DCIS). METHODS: We enrolled 65 biopsy-confirmed DCIS patients (62 unilateral, 3 bilateral) who underwent (18) F-FDG PET, diffusion-weighted imaging (DWI), or breast-specific gamma imaging (BSGI). We measured SUV max and intratumoral metabolic heterogeneity by the area under the curve (AUC) of cumulative SUV histograms (CSH) on PET, tumour-to-normal ratio (TNR) and coefficient of variation (COV) as an index of heterogeneity on BSGI, minimum ADC (ADC min ) and ADC difference (ADC diff ) as an index of heterogeneity on DWI...
December 2015: European Radiology
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