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https://www.readbyqxmd.com/read/27914357/moving-toward-heutagogical-learning-illuminating-undergraduate-nursing-students-experiences-in-a-flipped-classroom
#1
Rebecca D Green, Maura C Schlairet
BACKGROUND: Nurse educators rely on the tenets of educational theory and evidence-based education to promote the most effective curriculum and facilitate the best outcomes. The flipped classroom model, in which students assume personal responsibility for knowledge acquisition in a highly engaging and interactive environment, supports self-directed learning and the unique needs of clinical education. OBJECTIVE: To understand how students perceived their experiences in the flipped classroom and how students' learning dispositions were affected by the flipped classroom experience...
November 25, 2016: Nurse Education Today
https://www.readbyqxmd.com/read/27914352/searching-for-novel-modes-of-toxic-actions-of-oil-spill-using-e-%C3%A2-coli-live-cell-array-reporter-system-a-hebei-spirit-oil-spill-study
#2
Dawoon Jung, Miao Guan, Sangwoo Lee, Cheolmin Kim, Hyesoo Shin, Seongjin Hong, Un Hyuk Yim, Won Joon Shim, John P Giesy, Jong Seong Khim, Xiaowei Zhang, Kyungho Choi
Oil is a complex mixture of numerous compounds. Therefore, oil spills near shore can cause various adverse effects on coastal ecosystems. However, most toxicological assessments conducted on oil spill sites have focused on limited modes of toxic actions. In the present study, we utilized the Escherichia coli (E. coli) live cell array system (LCA) to identify novel modes of toxicities of the oil spill-affected sediments. For this purpose, sediment samples were collected from an area heavily polluted by Hebei Spirit oil spill (HSOS) incident of 2007...
November 30, 2016: Chemosphere
https://www.readbyqxmd.com/read/27914330/synergistic-effect-of-p-n-heterojunction-supporting-and-zeolite-nanoparticles-in-enhanced-photocatalytic-activity-of-nio-and-sno2
#3
Hadis Derikvandi, Alireza Nezamzadeh-Ejhieh
Increased photocatalytic activity of NiO and SnO2 was achieved by coupling and supporting of them onto clinoptilolite nanoparticles (NC) via calcination of Ni(II)-Sn(IV) - exchanged NC in photocatalytic degradation of metronidazole (MZ) aqueous solution. XRD, XRF, FTIR, SEM, X-ray mapping, DRS, TEM, BET Cyclic voltammetry and electrochemical impedance spectroscopy techniques (EIS) were used for characterization of samples. Red shift occurred in bang gap energies of the coupled semiconductors with respect to monocomponent one...
November 21, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27914317/the-disgust-related-images-dirti-database-validation-of-a-novel-standardized-set-of-disgust-pictures
#4
Anke Haberkamp, Julia Anna Glombiewski, Filipp Schmidt, Antonia Barke
Selecting appropriate stimuli is a major challenge of affective research. Although several standardized databases for affective pictures exist, none of them focus on discrete emotions such as disgust. Validated pictures inducing discrete emotions are still limited, and this presents a problem for researchers interested in studying different facets of disgust. In this paper, we introduce the DIsgust-RelaTed-Images (DIRTI) picture set. The set consists of 240 disgust-inducing pictures divided into six categories (food, animals, body products, injuries/infections, death, and hygiene)...
November 23, 2016: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/27914316/does-the-proportion-of-pay-linked-to-performance-affect-the-job-satisfaction-of-general-practitioners
#5
Thomas Allen, William Whittaker, Matt Sutton
There is concern that pay-for-performance (P4P) can negatively affect general practitioners (GPs) by reducing their autonomy, increasing their wage dispersion or eroding their intrinsic motivation. This is especially a concern for the Quality and Outcomes Framework (QOF), a highly powered P4P scheme for UK GPs. The QOF affected all GPs but the exposure of their income to P4P varied. GPs did not know their level of exposure before the QOF was introduced and could not choose or manage it. We examine whether changes in GPs' job satisfaction before and after the introduction of the QOF in 2004 were correlated with the proportion of their income that became exposed to P4P...
November 24, 2016: Social Science & Medicine
https://www.readbyqxmd.com/read/27914299/the-effects-of-fluorine-substitution-on-the-chemical-properties-and-inhibitory-capacity-of-donepezil-anti-alzheimer-drug-density-functional-theory-and-molecular-docking-calculations
#6
Azita Khosravan, Safora Marani, Mohammad Sadegh Sadeghi Googheri
Drug fluorination has the potential to reproduce useful drugs with decreasing the side effect of them. Identifying the effect of this improvement on the chemical properties and biological interactions of drug symbolizes a meaningful progress in drug design. Here the fluorination of Donepezil as an anti-Alzheimer drug, including 7 fluorinated derivatives of it, was investigated computationally. In the first part of our calculations, the most important chemical properties of drug that affects the drug efficiency were investigated by applying the M06/6-31g (d, p) and M062X/6-31g (d, p) levels of theories...
November 25, 2016: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/27914298/effects-of-environmental-noise-exposure-on-dna-methylation-in-the-brain-and-metabolic-health
#7
Liqiong Guo, Peng-Hui Li, Hua Li, Elena Colicino, Silvia Colicino, Yi Wen, Ruiping Zhang, Xiaotian Feng, Timothy M Barrow, Akin Cayir, Andrea A Baccarelli, Hyang-Min Byun
Environmental noise exposure is associated with adverse effects on human health including hearing loss, heart disease, and changes in stress-related hormone levels. Alteration in DNA methylation in response to environmental exposures is a well-known phenomenon and it is implicated in many human diseases. Understanding how environmental noise exposures affect DNA methylation patterns may help to elucidate the link between noise and adverse effects on health. In this pilot study we examined the effects of environmental noise exposure on DNA methylation of genes related to brain function and investigated whether these changes are related with metabolic health...
November 30, 2016: Environmental Research
https://www.readbyqxmd.com/read/27914294/selective-agonism-of-mglu8-receptors-by-s-3-4-dicarboxyphenylglycine-does-not-affect-sleep-stages-in-the-rat
#8
María Cavas, Gianluigi Scesa, Mercedes Martín-López, José Francisco Navarro
BACKGROUND: Metabotropic glutamate receptors (mGlu) play a role in a number of physiological processes and behaviors, as well as in certain pathological conditions and diseases. New drugs targetting mGlu receptors are being developed with treatment purposes. Recent data indicates that glutamate is involved in sleep, and pharmacological manipulation of distinct subtypes of mGlu receptors affect sleep. Here the consequences of selective pharmacological agonism of mGlu8 receptor upon sleep and wakefulness are explored for the first time...
September 22, 2016: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/27914290/the-interaction-of-surfactants-with-plastic-and-copper-plumbing-materials-during-decontamination
#9
Karen S Casteloes, Gamini P Mendis, Holly K Avins, John A Howarter, Andrew J Whelton
The study goal was to examine the effectiveness of surfactants to decontaminate plastic and copper potable water plumbing components. Several common potable water pipe and gasket plastics were examined as well as Alconox(®) detergent, Dawn(®) soap, and MAGIT-DG 100 surfactants. Results showed that the MAGIT-DG 100 solutions permeated all plastics within 3days, effectively compromising tensile strength (-82%), physical dimension (+43% volume, +45% weight), and oxidative resistance (-15%). A variety of MAGIT-DG 100 solution compounds permeated plastic samples, not just the declared major ingredient...
November 25, 2016: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/27914274/the-adaptive-psychological-changes-of-elective-induction-of-labor-in-breastfeeding-women
#10
Vincenzo Zanardo, Martina Bertin, Laura Sansone, Laura Felice
BACKGROUND: Labor induction has been associated with breastfeeding suppression, but reasons for why this association exists have not been well determined. METHODS: We examined the influence of elective labor induction by vaginal prostaglandin at gestational week 41(+3)days on affective, cognitive, and behavioural adaptations early in puerperium and on breastfeeding pattern at 1 and 3months. RESULTS: One hundred and eighty consecutive puerperae were assigned to two groups: mothers having received vaginal prostaglandin E2 gel (Prepidil®, dinoprostone) before labor (PGE group, n=90) and mothers having received no treatment (unmedicated group, n=90)...
November 30, 2016: Early Human Development
https://www.readbyqxmd.com/read/27914258/centralised-decentralised-or-hybrid-sanitation-systems-economic-evaluation-under-urban-development-uncertainty-and-phased-expansion
#11
Ivar Roefs, Brendo Meulman, Jan H G Vreeburg, Marc Spiller
Sanitation systems are built to be robust, that is, they are dimensioned to cope with population growth and other variability that occurs throughout their lifetime. It was recently shown that building sanitation systems in phases is more cost effective than one robust design. This phasing can take place by building small autonomous decentralised units that operate closer to the actual demand. Research has shown that variability and uncertainty in urban development does affect the cost effectiveness of this approach...
November 23, 2016: Water Research
https://www.readbyqxmd.com/read/27914237/religion-in-child-sexual-abuse-forensic-interviews
#12
Amy C Tishelman, Lisa A Fontes
Religion is an under-studied factor affecting children's sexual victimization and their willingness to discuss such experiences. In this qualitative study, 39 child forensic interviewers and child advocacy center (CAC) directors in the United States discussed religious influences on children's sexual abuse experiences, their relationships to CACs, and their disclosures in the forensic setting. Participants reported both harmonious and dissonant interactions between religiously observant children and families on one hand and child advocacy centers on the other...
November 30, 2016: Child Abuse & Neglect
https://www.readbyqxmd.com/read/27914234/food-gastrointestinal-ph-and-models-of-oral-drug-absorption
#13
REVIEW
Ahmad Y Abuhelwa, Desmond B Williams, Richard N Upton, David J R Foster
This article reviews the major physiological and physicochemical principles of the effect of food and gastrointestinal (GI) pH on the absorption and bioavailability of oral drugs, and the various absorption models that are used to describe/predict oral drug absorption. The rate and extent of oral drug absorption is determined by a complex interaction between a drug's physicochemical properties, GI physiologic factors, and the nature of the formulation administered. GI pH is an important factor that can markedly affect oral drug absorption and bioavailability as it may have significant influence on drug dissolution & solubility, drug release, drug stability, and intestinal permeability...
November 30, 2016: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/27914218/disruptive-influences-on-research-in-academic-pathology-departments-proposed-changes-to-the-common-rule-governing-informed-consent-for-research-use-of-biospecimens-and-to-rules-governing-return-of-research-results
#14
REVIEW
Mark E Sobel, Jennifer C Dreyfus
Academic pathology departments will be dramatically affected by proposed United States federal government regulatory initiatives. Pathology research will be substantially altered if proposed changes to the Common Rule (Code of Federal Regulations: Protection of Human Subjects title 45 CFR 46) and regulations governing the return of individual research results are approved and finalized, even more so now that the Precision Medicine initiative has been launched. Together, these changes are disruptive influences on academic pathology research as we know it, straining limited resources and compromising advances in diagnostic and academic pathology...
November 30, 2016: American Journal of Pathology
https://www.readbyqxmd.com/read/27914215/lysine-specific-demethylase-1-lsd1-inhibitor-s2101-induces-autophagy-via-the-akt-mtor-pathway-in-skov3-ovarian-cancer-cells
#15
Shujun Feng, Ye Jin, Mengjiao Cui, Jianhua Zheng
BACKGROUND S2101 is one of the most potent LSD1 inhibitors, which can inhibit ovarian cancer cells viability. This study aimed to detect the mechanism behind the anticancer properties of S2101 in SKOV3 ovarian cells. MATERIAL AND METHODS Cell viability was tested by Cell Counting Kit-8 (CCK-8) assay. Cellular apoptosis and autophagy were evaluated by flow cytometric analysis using Annexin-V/PI staining methods and Green fluorescent protein (GFP)-fused-LC3 (GFP-LC3), respectively. Western blotting was performed for analyzing the Bax, Bcl-2, mTOR, p- mTOR, p62, LC3-I, LC3-II, AKT, and p-AKT protein expression...
December 3, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27914214/antithrombin-improves-the-maternal-and-neonatal-outcomes-but-not-the-angiogenic-factors-in-extremely-growth-restricted-fetuses-at-28-weeks-of-gestation
#16
Midori Fujisaki, Ken Furuta, Masanao Ohhashi, Seishi Furukawa, Yuki Kodama, Yasuyuki Kawagoe, Hiroshi Sameshima, Tsuyomu Ikenoue
AIMS: Severe preterm fetal growth restriction (FGR) remote from term is problematic. We aimed to investigate the effect of maternally-administered antithrombin on maternal and neonatal outcomes. A prospective, one-arm, pilot study was performed in 14 women with severe FGR (≤5th centile) at <28 weeks of gestation, without hypertensive disorders. Maternal plasma concentrations of soluble Feline McDonough Sarcoma (FMS)-like trypsin kinase-1 (sFlt-1) and placental growth factor (PlGF) were measured and categorized into three groups: group 1; low sFlt-1 and high PlGF, group 2; moderate sFlt-1 and low PlGF, and group 3; high sFlt-1 and low PlGF...
December 3, 2016: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/27914205/mitochondrial-genotype-and-phenotypic-plasticity-of-gene-expression-in-response-to-cold-acclimation-in-killifish
#17
Timothy M Healy, Heather J Bryant, Patricia M Schulte
Adjustments of aerobic metabolic processes are critical components of organismal responses to environmental change that require tight co-ordination between the nuclear and mitochondrial genomes. Intraspecific differences in mitochondrial genotype can affect gene transcription in both genomes. Thus, variation in mitochondrial genotype may be associated with differences in the plasticity of gene expression when organisms are faced with changes in environmental conditions. Cold acclimation is known to result in metabolic responses involving increases in mitochondrial amount and capacity, suggesting that low temperatures may pose a particular challenge when co-ordinating the functions of the nuclear and mitochondrial genomes...
December 3, 2016: Molecular Ecology
https://www.readbyqxmd.com/read/27914196/ecological-caring-revisiting-the-original-ideas-of-caring-science
#18
Helena Dahlberg, Albertine Ranheim, Karin Dahlberg
The aim of this empirically grounded philosophical paper is to explore the notion of holistic care with the intention to expand it into a notion of ecological care and in such a way revisit the original ideas of caring science. The philosophical analysis, driven by lifeworld theory and especially Merleau-Ponty's philosophy, is firmly rooted in contemporary clinical care. We used interview data from patients in a study at an anthroposophic clinic in Sweden, which forms part of an ecological community with, for example, ecological agriculture...
2016: International Journal of Qualitative Studies on Health and Well-being
https://www.readbyqxmd.com/read/27914187/enhanced-nutrition-improves-growth-and-increases-blood-adiponectin-concentrations-in-very-low-birth-weight-infants
#19
Elin W Blakstad, Sissel J Moltu, Britt Nakstad, Marit B Veierød, Kenneth Strømmen, Pétur B Júlíusson, Astrid N Almaas, Arild E Rønnestad, Kristin Brække, Christian A Drevon, Per O Iversen
BACKGROUND: Adequate nutrient supply is essential for optimal postnatal growth in very low birth weight (VLBW, birth weight<1,500 g) infants. Early growth may influence the risk of metabolic syndrome later in life. OBJECTIVE: To evaluate growth and blood metabolic markers (adiponectin, leptin, and insulin-like growth factor-1 (IGF-1)) in VLBW infants participating in a randomized nutritional intervention study. DESIGN: Fifty VLBW infants were randomized to an enhanced nutrient supply or a standard nutrient supply...
2016: Food & Nutrition Research
https://www.readbyqxmd.com/read/27914182/positive-feelings-during-pregnancy-early-feeding-practices-and-infant-health
#20
Melissa A McManus, Ali A Khalessi, Joyce Lin, Jahanzeb Ashraf, Stephanie M Reich
BACKGROUND: Early parenting practices, like infant feeding, can impact children's physical health. Additionally, negative prenatal maternal affect can influence feeding choices, like breastfeeding, and can have a detrimental effect on children's health. However, little is known about the contribution of positive maternal affect during pregnancy on feeding practices and children's health. METHOD: This study explored whether positive prenatal feelings influenced children's health during the first 18 months, and whether early feeding practices mediated the relationship between these two variables...
December 3, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
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