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https://www.readbyqxmd.com/read/29327566/upper-extremity-access-options-for-complex-endovascular-aortic-interventions
#1
Kedar S Lavingia, Anahita Dua, Jordan R Stern
The advancement of endovascular therapy has led to minimally invasive solutions to increasingly complex aortic pathology, including thoracoabdominal aneurysms and those involving the visceral segment. Upper extremity access is beneficial in a variety of these complex interventions, and may be absolutely required for certain procedures such as placement of parallel chimney grafts. Traditionally, the brachial artery has been the primary access site on the arm, using either a percutaneous or open approach. Brachial access is safe and effective, and remains suitable for the majority of clinical situations...
January 9, 2018: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29319031/association-of-comorbid-anxiety-and-depression-with-chronic-obstructive-pulmonary-disease
#2
Ruchi Dua, Anindya Das, Abhishek Kumar, Sandeep Kumar, Mayank Mishra, Kapil Sharma
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a disease with known systemic manifestations including psychiatric comorbidities most commonly being depression and/or anxiety. Studies regarding the association of these psychiatric comorbidities in terms of symptom scores, spirometric variables, and hospitalizations among patients of COPD are lacking, especially in India. MATERIALS AND METHODS: One hundred and twenty-eight patients of COPD attending the Outpatient Department of AIIMS Rishikesh, and fulfilling inclusion criteria were screened by Hospital Anxiety and Depression Scale, and those who scored above the cutoff underwent psychiatric evaluation using the International Classification of Diseases, Tenth Edition Diagnostic Criteria for Research for confirmation of their diagnosis...
January 2018: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/29288771/s-allyl-cysteine-regulates-the-tnf%C3%AE-induced-muscle-wasting-by-suppressing-proteolysis-and-regulating-the-inflammatory-molecules-in-skeletal-muscle-myotubes
#3
Vikas Dutt, Vikram Saini, Prachi Gupta, Nirmaljeet Kaur, Manju Bala, Ravindra Gujar, Anita Grewal, Sanjeev Gupta, Anita Dua, Ashwani Mittal
BACKGROUND: Elevated levels of inflammatory molecules are the key players in muscle wasting/atrophy leading to human morbidity. TNFα is a well-known pro-inflammatory cytokine implicated in the pathogenesis of muscle wasting under diverse clinical settings. S-allyl cysteine (SAC), an active component of garlic (Allium sativum), has established anti-oxidant and anti-inflammatory effects in various cell types. However, the impact of SAC on skeletal muscle pathology remains unexplored. Owing to the known anti-inflammatory properties of SAC, we investigate whether pre-treatment with SAC has a protective role in TNFα induced atrophy in cultured myotubes...
December 27, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29279882/new-therapeutic-directions-to-treat-underactive-bladder
#4
REVIEW
Toby C Chai, Tambudzai Kudze
Underactive bladder (UAB) is a term used to describe a constellation of symptoms that is perceived by patients suggesting bladder hypocontractility. Urodynamic measurement that suggest decreased contractility of the bladder is termed detrusor underactivity (DUA). Regulatory approved specific management options with clinically proven ability to increase bladder contractility do not currently exist. While DUA specific treatments presumably will focus on methods to increase efficiency of bladder emptying capability relying on augmenting the motor pathway in the micturition reflex, other approaches include methods to augment the sensory (afferent) contribution to the micturition reflex which could result in increased detrusor contractility...
December 2017: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/29276355/psychiatry-and-cinema-what-can-we-learn-from-the-magical-screen
#5
Soumitra DAS, Nimisha Doval, Shabna Mohammed, Neha Dua, Seshadri Sekhar Chatterjee
Cinema, a vehicle of social transformation sheds light on different aspects of mental illness. Due to its dramatic and stigmatising depictions, it often spreads a negative aspect of psychiatric disorders and the patients who are suffering from them. Though it brings out a few positive and inspiring stories, they are sparse in comparison to its negative views. Here, we are going to describe the dual impact of cinema on psychiatry.
October 25, 2017: Shanghai Archives of Psychiatry
https://www.readbyqxmd.com/read/29250217/atrial-fibrillation-is-associated-with-increased-pacemaker-implantation-rates-in-the-placement-of-aortic-transcatheter-valve-partner-trial
#6
Angelo B Biviano, Tamim Nazif, Jose Dizon, Hasan Garan, Mark Abrams, Jessica Fleitman, Dua Hassan, Samir Kapadia, Vasilis Babaliaros, Ke Xu, Josep Rodes-Cabau, Wilson Y Szeto, William F Fearon, Danny Dvir, Todd Dewey, Mathew Williams, Steven Kindsvater, Michael J Mack, John G Webb, D Craig Miller, Craig R Smith, Martin B Leon, Susheel Kodali
Atrial fibrillation (AF) is associated with worse outcomes in many cardiovascular diseases. There are few data examining pacemaker implantation rates and indications in patients with AF who undergo transcatheter aortic valve replacement (TAVR). To examine the impact of AF on the incidence of and indications for pacemakers in patients undergoing TAVR, we evaluated data of 1723 patients without pre-existing pacemakers who underwent TAVR in the Placement of AoRTic TraNscathetER Valve (PARTNER) trial. Permanent pacemaker implantation rates and indications were compared in groups based on baseline and discharge heart rhythm: sinus rhythm (SR) vs...
June 2017: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/29249232/an-integrated-pathology-and-ultrasonography-based-simulation-for-training-in-performing-kidney-biopsy%C3%A2
#7
Shree G Sharma, John M Arthur, Stephen M Bonsib, Kevin D Phelan, Manisha Singh, Nithin Karakala, Kelly W Bulloch, Vandana Dua Niyyar, Juan Carlos Q Velez
BACKGROUND: Medical practice trends and limitations in trainees' duty hours have diminished the interest and exposure of nephrology fellows to percutaneous kidney biopsy (PKB). We hypothesized that an integrated nephrology-pathology-led simulation may be an effective educational tool. MATERIALS AND METHODS: A 4-hour PKB simulation workshop (KBSW), led by two ultrasonography (US)-trained nephrologists and two nephropathologists, consisted of 6 stations: 1) diagnostic kidney US with live patients, 2) kidney pathology with plasticine models of embedded torso cross-sections, 3) US-based PKB with mannequin (Blue Phantom™), 4) kidney pathology with dissected cadavers, 5) US-based PKB in lightly-embalmed cadavers, and 6) tissue retrieval adequacy examination by microscope...
December 18, 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/29246889/nerve-terminals-at-the-human-corneoscleral-limbus
#8
Mouhamed A Al-Aqaba, Fady S Anis, Imran Mohammed, Harminder S Dua
AIMS: To demonstrate and characterise distinct subepithelial compact nerve endings (CNE) at the human corneoscleral limbus. METHODS: Ten fresh human donor corneoscleral discs (mean age, 67 years) and 26 organ-cultured corneoscleral rims (mean age, 59 years) were studied. All samples were subjected to enzyme histochemical staining related to endogenous acetylcholinesterase present in nerve tissue and H&E staining. Whole-mount en face imaging with NanoZoomer digital pathology microscope and serial cross-section imaging with light microscope were undertaken...
December 15, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29244982/diagnostic-dilemma-primary-peritoneal-mesothelioma-with-para-occupational-asbestos-exposure
#9
Kirby R Qin, Divyanshu Dua
No abstract text is available yet for this article.
December 2017: Journal of Global Oncology
https://www.readbyqxmd.com/read/29241979/acalabrutinib-in-relapsed-or-refractory-mantle-cell-lymphoma-ace-ly-004-a-single-arm-multicentre-phase-2-trial
#10
Michael Wang, Simon Rule, Pier Luigi Zinzani, Andre Goy, Olivier Casasnovas, Stephen D Smith, Gandhi Damaj, Jeanette Doorduijn, Thierry Lamy, Franck Morschhauser, Carlos Panizo, Bijal Shah, Andrew Davies, Richard Eek, Jehan Dupuis, Eric Jacobsen, Arnon P Kater, Steven Le Gouill, Lucie Oberic, Taduesz Robak, Todd Covey, Richa Dua, Ahmed Hamdy, Xin Huang, Raquel Izumi, Priti Patel, Wayne Rothbaum, J Greg Slatter, Wojciech Jurczak
BACKGROUND: Bruton tyrosine kinase is a clinically validated target in mantle cell lymphoma. Acalabrutinib (ACP-196) is a highly selective, potent Bruton tyrosine kinase inhibitor developed to minimise off-target activity. METHODS: In this open-label, phase 2 study, oral acalabrutinib (100 mg twice per day) was given to patients with relapsed or refractory mantle cell lymphoma, until disease progression or unacceptable toxicity. The primary endpoint was overall response assessed according to the Lugano classification, and safety analyses were done in all participants...
December 11, 2017: Lancet
https://www.readbyqxmd.com/read/29235170/scaling-up-integrated-early-childhood-development-programs-lessons-from-four-countries
#11
R Pérez-Escamilla, V Cavallera, M Tomlinson, T Dua
BACKGROUND: There is still limited knowledge regarding the translation of early child development (ECD) knowledge into effective policies and large-scale programmes. A variety of frameworks that outline the key steps in scaling up exist, but we argue that taking a complex adaptive systems (CAS) approach assists in understanding the complex, dynamic processes that result in programmes being taken to scale. OBJECTIVES: The objective of this study is to examine the process of scaling up four major country-level ECD programmes through the application of a CAS framework...
January 2018: Child: Care, Health and Development
https://www.readbyqxmd.com/read/29233670/safety-and-efficacy-of-lumen-apposing-metal-stents-with-and-without-simultaneous-double-pigtail-plastic-stents-for-draining-pancreatic
#12
Murad Aburajab, Zachary Smith, Abdul Khan, Kulwinder Dua
BACKGROUND AND AIMS: Lumen-apposing metal stents (LAMSs) are used to perform necrosectomy in walled-off necrosis (WON). Although necrosectomy is not required for pancreatic pseudocyst (PP), an increasing number of PPs are also being drained with LAMSs in view of their ease of deployment. The aim of the present study was to evaluate the safety and efficacy of using LAMSs to drain PPs. METHODS: At one tertiary center, from January 2014 to May 2016, all consecutive patients with PPs were drained by LAMSs, and the data were retrospectively reviewed...
December 9, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29221873/modeling-and-prediction-of-regional-municipal-solid-waste-generation-and-diversion-in-canada-using-machine-learning-approaches
#13
Miyuru Kannangara, Rahul Dua, Leila Ahmadi, Farid Bensebaa
The main objective of this study was to develop models for accurate prediction of municipal solid waste (MSW) generation and diversion based on demographic and socio-economic variables, with planned application of generating Canada-wide MSW inventories. Models were generated by mapping residential MSW quantities with socio-economic and demographic parameters of 220 municipalities in the province of Ontario, Canada. Two machine learning algorithms, namely decision trees and neural networks, were applied to build the models...
December 5, 2017: Waste Management
https://www.readbyqxmd.com/read/29217445/factors-that-predict-failure-to-meet-mips-quality-measures-for-asymptomatic-carotid-endarterectomy
#14
Anahita Dua, Steven Koprowski, Fadwa Ali, Sapan S Desai
INTRODUCTION: The Physician Quality Reporting System (PQRS) created by the Centers for Medicare and Medicaid Services (CMS) financially penalizes providers who fail to meet expected quality of care measures. The purpose of this study is to evaluate the factors that predict failure to meet PQRS measures for carotid endarterectomy (CEA). METHODS: PQRS measures 260 (discharge by postoperative day 2 following CEA in asymptomatic patients) and 346 (rate of postoperative stroke or death following CEA in asymptomatic patients) were evaluated using hospital records from the state of Florida from 2008-2012...
December 4, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29214652/pharmacology-in-translation-the-preclinical-and-early-clinical-profile-of-the-novel-%C3%AE-2-3-functionally-selective-gabaa-receptor-positive-allosteric-modulator-pf-06372865
#15
Sarah A Nickolls, Rachel Gurrell, Guido van Amerongen, Juha Kammonen, Lishuang Cao, Adam R Brown, Clara Stead, Andy Mead, Christine Watson, Cathleen Hsu, Robert M Owen, Andy Pike, Rebecca L Fish, Laigao Chen, Ruolun Qiu, Evan D Morris, Gang Feng, Mark Whitlock, Donal Gorman, Joop van Gerven, David S Reynolds, Pinky Dua, Richard P Butt
BACKGROUND AND PURPOSE: Benzodiazepines (BZDs), non-selective positive allosteric modulators (PAMs) of GABAA receptors, have significant side-effects that limit their clinical utility. As many of these side-effects are mediated by the α1 subunit there has been a concerted effort to develop α2/3 subtype-selective PAMs. EXPERIMENTAL APPROACH: In vitro screening assays were used to identify molecules with functional selectivity for receptors containing α2/3 subunits over those containing α1 subunits...
December 7, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29199592/nephrotoxicity-in-rats-exposed-to-paracetamol-the-protective-role-of-moralbosteroid-a-steroidal-glycoside
#16
Gaurav Gupta, Dinesh Kumar Chellappan, Irene Satiko Kikuchi, Terezinha de Jesus Andreoli Pinto, Kavita Pabreja, Mohit Agrawal, Yogendra Singh, Juhi Tiwari, Kamal Dua
Paracetamol (PCM) has an acceptable safety profile when used at prescribed doses. However, it is now understood that paracetamol can damage the kidneys when administered as an overdose. In addition, oxidative stress can play a major role in causing nephrotoxicity. This investigation studies the efficacy of moralbosteroid isolated from M. alba stem bark. Nephrotoxicity was induced with administration of paracetamol. Nephroprotection was studied using two doses of the extract. The experimental animals were divided into four groups (n = 6)...
2017: Journal of Environmental Pathology, Toxicology and Oncology
https://www.readbyqxmd.com/read/29198937/cardiopulmonary-exercise-testing-in-the-evaluation-of-liver-disease-in-adults-who-have-had-the-fontan-operation
#17
Anushree Agarwal, Colin Cunnington, Aarthi Sabanayagam, Lucas Zier, Charles E McCulloch, Ian S Harris, Elyse Foster, Dougal Atkinson, Angela Bryan, Petra Jenkins, Jaspal Dua, Michael J Parker, Devinda Karunaratne, John A Moore, Jeffrey Meadows, Bernard Clarke, Johann Andreas Hoschtitzky, Vaikom Subramanian Mahadevan
BACKGROUND: Liver disease (LD) is a long-term complication in patients with a single ventricle who have had the Fontan operation. A decline in cardiopulmonary exercise testing (CPET) variables is associated with increased risk of hospitalization, but its association with LD is unknown. AIM: To determine the association between CPET variables and LD in adults who have had the Fontan operation. METHODS: We retrospectively reviewed the medical records from two tertiary institutions...
November 30, 2017: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/29193851/survival-of-corneal-nerve-sheath-structures-in-organ-cultured-donor-corneas
#18
Virinder K Dhillon, Mohamed S Elalfy, Marco Messina, Mouhamed Al-Aqaba, Harminder S Dua
PURPOSE: To study the morphology of human corneal nerves in eye bank organ-cultured corneas and in corneal grafts post-transplantation. METHODS: Thirty-seven organ-cultured corneas were divided into: Group-A, anterior 300-400 μm of 20 corneas used for Descemets stripping endothelial keratoplasty, and Group-B, 17 full-thickness corneas unsuitable for transplantation. Corneas whole mounts were stained for nerves using acetylcholinesterase technique and examined by NanoZoomer digital pathology microscope...
November 29, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29192691/patient-understanding-of-commonly-used-oral-medicine-terminology
#19
E Hayes, R Dua, E Yeung, K Fan
Introduction Communication within the doctor-patient relationship is complex due to a variety of reasons; a patient's understanding may not correspond with the clinician's vocabulary, resulting in misunderstanding, anxiety and ill-informed decision making. We investigated the understanding of terminology commonly used in oral and maxillofacial surgery and oral medicine clinics.Methods We investigated patients' understanding using a questionnaire-based study in the out-patient setting. Age, gender, first language and highest educational level were recorded...
December 1, 2017: British Dental Journal
https://www.readbyqxmd.com/read/29185148/therapeutic-prospects-of-micrornas-in-cancer-treatment-through-nanotechnology
#20
REVIEW
Rajendra Awasthi, Michael John Rathbone, Philip Michael Hansbro, Mary Bebawy, Kamal Dua
MicroRNAs (miRNAs) represent a new class of diagnostic and prognostic biomarker as well as new therapeutic targets in cancer therapy. miRNAs are gaining significant interest due to extensive advancements in knowledge since their discovery and, more recently, their translational application as therapeutic moieties and targets in the management of disease. miRNAs used in the treatment of cancer would position them as a new class of emerging therapeutic agents. Indeed, numerous candidate miRNAs have been identified as having therapeutic application in the treatment of cancer, but there is still much to learn about how to transform these into effective, patient-compliant, and targeted drug delivery systems...
November 28, 2017: Drug Delivery and Translational Research
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