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https://www.readbyqxmd.com/read/28637788/the-effects-of-neuromodulation-in-a-novel-obese-prone-rat-model-of-detrusor-underactivity
#1
Eric J Gonzalez, Warren M Grill
Obesity is a global epidemic associated with an increased risk for lower urinary tract dysfunction. Inefficient voiding and urinary retention may arise in late-stage obesity when the expulsive force of the detrusor smooth muscle cannot overcome outlet resistance. Detrusor underactivity (DUA) and impaired contractility may contribute to the pathogenesis of non-obstructive urinary retention. We used cystometry and electrical stimulation of peripheral nerves (pudendal and pelvic n.) to characterize and improve bladder function in urethane-anesthetized obese-prone (OP) and obese-resistant (OR) rats following diet-induced obesity (DIO)...
June 21, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28618086/jordanian-nurses-perception-and-interventions-related-to-promoting-smoking-cessation
#2
Inaam A Khalaf, Fathieh Abu-Moghli, Susan A LaRocco, Dua' Yousef Al-Maharma
AIMS AND OBJECTIVES: This research aims to determine nurses' perceptions related to smoking cessation, health promotion, and interventions provided to hospitalized patients. BACKGROUND: Smoking is a major health problem in Jordan. The cost for treating smoking- related health conditions is a significant strain on the health care system. Nurses are in an ideal position to encourage smoking cessation. Little is known about Jordanian nurses' perceptions related to smoking cessation issues...
June 15, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28614437/chronic-disease-in-childhood-and-adolescence-continuity-of-care-in-the-health-care-network
#3
Vanessa Medeiros da Nóbrega, Maria Elizabete de Amorim Silva, Leiliane Teixeira Bento Fernandes, Claudia Silveira Viera, Altamira Pereira da Silva Reichert, Neusa Collet
OBJECTIVE: To evaluate the continuity of care for children and adolescents with chronic diseases in the health care network. METHODS: This qualitative study was conducted between February and October 2013 with 12 families, six health managers, and 14 health professionals from different health care services in a municipality of the state of Paraíba, Brazil, using focal groups, semi-structured interviews, and medical record consultation. The data were analyzed by triangulation and thematic analysis...
June 12, 2017: Revista da Escola de Enfermagem da U S P
https://www.readbyqxmd.com/read/28607217/hotspots-in-ptpn11-gene-among-indian-children-with-noonan-syndrome
#4
Dhanya Lakshmi Narayanan, Himani Pandey, Amita Moirangthem, Kausik Mandal, Rekha Gupta, Ratna Dua Puri, S J Patil, Shubha R Phadke
OBJECTIVES: To test for PTPN11 mutations in clinically diagnosed cases of Noonan syndrome. METHODS: Seventeen individuals with clinical diagnosis of Noonan syndrome were included in the study. Sanger sequencing of all the 15 exons of PTPN11 was done. A genotype-phenotype correlation was attempted. RESULTS: Mutation in PTPN11 was detected in 11 out of 17 (64.7 %) patients with Noonan syndrome; 72% had mutation in exon 3 and 27 % had mutation in exon 13...
June 4, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28602032/comparative-evaluation-of-efficacy-and-safety-of-calcipotriol-versus-tacalcitol-ointment-both-in-combination-with-nbuvb-phototherapy-in-the-treatment-of-stable-plaque-psoriasis
#5
Ishita Dua, Kamal Aggarwal, V K Jain
BACKGROUND: Vitamin D analogues and NBUVB phototherapy are both well-established modalities of treatment in psoriasis. The objective of this open label, intra individual, left right study was to compare two different Vitamin D analogues, calcipotriol and tacalcitol, in combination with NBUVB phototherapy in chronic stable plaque psoriasis. METHODS: Thirty patients with stable plaque psoriasis were enrolled for a 12 week clinical trial. The target lesion on left side was treated topically with tacalcitol ointment once daily, while that on the right side was treated with calcipotriol ointment twice daily...
June 11, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/28600476/phase-ib-study-of-lumretuzumab-plus-cetuximab-or-erlotinib-in-solid-tumor-patients-and-evaluation-of-her3-and-heregulin-as-potential-biomarkers-of-clinical-activity
#6
Didier Meulendijks, Wolfgang Jacob, Emile E Voest, Morten Mau-Sørensen, Maria Martinez-Garcia, Alvaro Taus, Tania Fleitas, Andres Cervantes, Martijn Lolkema, Marlies Hg Langenberg, Maja J A de Jonge, Stefan Sleijfer, Ji-Youn Han, Antonio Calles, Enriqueta Felip, Sang-We Kim, Jan H M Schellens, Sabine Wilson, Marlene Thomas, Maurizio Ceppi, Georgina Meneses-Lorente, Ian James, Suzana Vega Harring, Rajiv Dua, Maitram Nguyen, Lori Steiner, Celine Adessi, Francesca Michielin, Birgit Bossenmaier, Martin Weisser, Ulrik Lassen
<br /> <p>This study investigated the safety, clinical activity and target-associated biomarkers of lumretuzumab, a humanized, glycoengineered, anti-HER3 monoclonal antibody (mAb), in combination with the EGFR-blocking agents erlotinib or cetuximab in patients with advanced HER3-positive carcinomas.</p> <br />Experimental Design: <br /> <p>The study included two parts: dose escalation and dose extension phases with lumretuzumab in combination with either cetuximab or erlotinib, respectively...
June 9, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28594521/pediatric-distal-radius-fractures
#7
Karan Dua, Joshua M Abzug, Andrea Sesko Bauer, Roger Cornwall, Theresa O Wyrick
Distal radius fractures are the most common orthopaedic injury that occur in the pediatric population. The annual incidence of distal radius fractures has increased as a result of earlier participation in sporting activities, increased body mass index, and decreased bone mineral density. Most distal radius fractures are sustained after a fall onto an outstretched arm that results in axial compression on the extremity or from direct trauma to the extremity. Physeal fractures of the distal radius are described based on the Salter-Harris classification system...
February 15, 2017: Instructional Course Lectures
https://www.readbyqxmd.com/read/28594518/pediatric-phalanx-fractures
#8
Joshua M Abzug, Karan Dua, Andrea Sesko Bauer, Roger Cornwall, Theresa O Wyrick
Phalangeal fractures are the most common type of hand fracture that occurs in the pediatric population and account for the second highest number of emergency department visits in the United States for fractures. The incidence of phalangeal fractures is the highest in children aged 10 to 14 years, which coincides with the time that most children begin playing contact sports. Younger children are more likely to sustain a phalangeal fracture in the home setting as a result of crush and laceration injuries. Salter-Harris type II fractures of the proximal phalanx are the most common type of finger fracture...
February 15, 2017: Instructional Course Lectures
https://www.readbyqxmd.com/read/28594494/carpal-tunnel-syndrome-initial-management-and-the-treatment-of-recalcitrant-patients
#9
Karan Dua, A Lee Osterman, Joshua M Abzug
Carpal tunnel syndrome (CTS) is a focal compressive neuropathy of the median nerve at the level of the wrist. CTS is the most common type of compressive neuropathy that occurs in the upper extremity. Typically, patients with CTS have paresthesia, pain, and numbness in the radial three and one-half digits. Nighttime symptoms are more common earlier in the disease process, with daytime symptoms becoming more frequent as CTS progresses. Electrodiagnostic studies may be performed to confirm a diagnosis of CTS or to obtain a baseline before surgical treatment; however, electrodiagnostic studies may be normal in a subset of patients who have CTS...
February 15, 2017: Instructional Course Lectures
https://www.readbyqxmd.com/read/28591353/noncommunicable-diseases-and-the-use-of-health-services-analysis-of-the-national-health-survey-in-brazil
#10
Deborah Carvalho Malta, Regina Tomie Ivata Bernal, Margareth Guimarães Lima, Silvânia Suely Caribé de Araújo, Marta Maria Alves da Silva, Maria Imaculada de Fátima Freitas, Marilisa Berti de Azevedo Barros
OBJECTIVE: To assess whether sex, education level, and health insurance affect the use of health services among the adult Brazilian population with chronic noncommunicable diseases (NCD). METHODS: Data from a cross-sectional survey were analyzed, the National Health Survey (PNS). Frequency of use of services in the population that referred at least one NCD were compared with the frequency from a population that did not report NCD, according to sex, education level, health insurance, and NCD number (1, 2, 3, 4, or more)...
June 1, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/28591352/depression-and-health-behaviors-in-brazilian-adults-pns-2013
#11
Marilisa Berti de Azevedo Barros, Margareth Guimarães Lima, Renata Cruz Soares de Azevedo, Lhais Barbosa de Paula Medina, Claudia de Souza Lopes, Paulo Rossi Menezes, Deborah Carvalho Malta
OBJECTIVE: To evaluate the prevalence of health-related behaviors according to presence and type of depression in Brazilian adults. METHODS: Based on a sample of 49,025 adults (18 to 59 years) from the National Survey on Health 2013 (PNS 2013), we estimated the prevalence of health-related behaviors (smoking; passive smoking; frequent or risky alcohol consumption; leisure time physical activity; time watching TV; and eating pattern indicators), according to the presence of depression (minor and major), evaluated by the Patient Health Questionnaire - 9 (PHQ-9), and the report of depressive mood (in up to seven days or more than seven days) over a two-week period...
June 1, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/28591351/use-of-and-access-to-health-services-in-brazil-2013-national-health-survey
#12
Sheila Rizzato Stopa, Deborah Carvalho Malta, Camila Nascimento Monteiro, Célia Landmann Szwarcwald, Moisés Goldbaum, Chester Luiz Galvão Cesar
OBJECTIVE: To analyze the use of health services in the Brazilian population by sociodemographic factors, according to data from the 2013 Brazilian National Health Survey. METHODS: The study analyzed data from 205,000 Brazilian citizens in all age groups who participated in the Brazilian National Health Survey, a cross-sectional study carried out in 2013. Prevalence and confidence intervals were estimated for indicators related to access to and use of health services according to age group, level of education of head of household, and Brazilian macroregions...
June 1, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/28591320/degree-of-agreement-between-cardiovascular-risk-stratification-tools
#13
Guilherme Thomé Garcia, Ana Maria Nunes de Faria Stamm, Ariel Córdova Rosa, Antônio Carlos Marasciulo, Rodrigo Conill Marasciulo, Cristian Battistella, Alexandre Augusto de Costa Remor
Background: Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in Brazil, and primary prevention care may be guided by risk stratification tools. The Framingham (FRS) and QRISK-2 (QRS) risk scores estimate 10-year overall cardiovascular risk in asymptomatic individuals, but the instrument of choice may lead to different therapeutic strategies. Objective: To evaluate the degree of agreement between FRS and QRS in 10-year overall cardiovascular risk stratification in disease-free individuals...
May 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28591301/a-grounded-theory-study-of-the-intention-of-nurses-to-leave-the-profession
#14
Leyla Alilu, Vahid Zamanzadeh, Leila Valizadeh, Hosein Habibzadeh, Mark Gillespie
Objective: this study explores the process of the development of an intention to leave bedside nursing. Method: the process was studied from the perspective of 21 nurses using the grounded theory method. Data were collected using semi-structured interviews and the constant comparative method of Corbin and Strauss was used for data analysis. Results: according to the participants, the two main categories, "social image of nursing", and "culture and structure of the bedside", were the contextual factors that influence why nurses are leaving bedside care provision...
June 5, 2017: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/28587935/human-antimicrobial-peptides-in-ocular-surface-defense
#15
REVIEW
Imran Mohammed, Dalia G Said, Harminder S Dua
Sight depends on the passage of light through the transparent cornea and being focused on the fovea. Its exposed position renders it vulnerable to microbial infection. The cornea has developed a wide array of defense mechanisms against infection, of which endogenous antimicrobial peptides (AMPs) are key. AMPs are essentially small molecular weight cationic peptides with a wide range of activity against virus, bacteria, fungi and parasites. Some proteins such as RNases and S100As are also included in this group...
June 3, 2017: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/28587912/development-of-groundwater-vulnerability-zones-in-a-data-scarce-eogenetic-karst-area-using-head-guided-zonation-and-particle-tracking-simulation-methods
#16
Dua K S Y Klaas, Monzur Alam Imteaz, Arul Arulrajah
Delineation of groundwater vulnerability zones based on a valid groundwater model is crucial towards an accurate design of management strategies. However, limited data often restrain the development of a robust groundwater model. This study presents a methodology to develop groundwater vulnerability zones in a data-scarce area. The Head-Guided Zonation (HGZ) method was applied on the recharge area of Oemau Spring in Rote Island, Indonesia, which is under potential risk of contamination from rapid land use changes...
May 28, 2017: Water Research
https://www.readbyqxmd.com/read/28587082/natural-products-as-alternative-choices-for-p-glycoprotein-p-gp-inhibition
#17
REVIEW
Saikat Dewanjee, Tarun K Dua, Niloy Bhattacharjee, Anup Das, Moumita Gangopadhyay, Ritu Khanra, Swarnalata Joardar, Muhammad Riaz, Vincenzo De Feo, Muhammad Zia-Ul-Haq
Multidrug resistance (MDR) is regarded as one of the bottlenecks of successful clinical treatment for numerous chemotherapeutic agents. Multiple key regulators are alleged to be responsible for MDR and making the treatment regimens ineffective. In this review, we discuss MDR in relation to P-glycoprotein (P-gp) and its down-regulation by natural bioactive molecules. P-gp, a unique ATP-dependent membrane transport protein, is one of those key regulators which are present in the lining of the colon, endothelial cells of the blood brain barrier (BBB), bile duct, adrenal gland, kidney tubules, small intestine, pancreatic ducts and in many other tissues like heart, lungs, spleen, skeletal muscles, etc...
May 25, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28573367/3d-microfabricated-scaffolds-and-microfluidic-devices-for-ocular-surface-replacement-a-review
#18
Elisabetta Prina, Pritesh Mistry, Laura E Sidney, Jing Yang, Ricky D Wildman, Marina Bertolin, Claudia Breda, Barbara Ferrari, Vanessa Barbaro, Andrew Hopkinson, Harminder S Dua, Stefano Ferrari, Felicity R A J Rose
In recent years, there has been increased research interest in generating corneal substitutes, either for use in the clinic or as in vitro corneal models. The advancement of 3D microfabrication technologies has allowed the reconstruction of the native microarchitecture that controls epithelial cell adhesion, migration and differentiation. In addition, such technology has allowed the inclusion of a dynamic fluid flow that better mimics the physiology of the native cornea. We review the latest innovative products in development in this field, from 3D microfabricated hydrogels to microfluidic devices...
June 1, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/28562813/opioid-analgesic-administration-in-patients-with-suspected-drug-use
#19
Maria Clara Giorio Dutra Kreling, Cibele Andrucioli de Mattos-Pimenta
Objective: To identify the prevalence of patients suspected of drug use according to the nursing professionals' judgement, and compare the behavior of these professionals in opioid administration when there is or there is no suspicion that patient is a drug user. Method: A cross-sectional study with 507 patients and 199 nursing professionals responsible for administering drugs to these patients. The Chi-Square test, Fisher's Exact and a significance level of 5% were used for the analyzes...
May 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/28562811/use-of-the-diffusion-of-innovation-model-in-venous-ulcers-by-specialized-professionals
#20
Eline Lima Borges, Maria Helena Larcher Caliri, Vanderlei José Haas, Aidê Ferreira Ferraz, Josimare Otoni Spira, Ana Carolina Tyrone
Objective: To analyze the influence of the evidence and of the opinion of peers on the decisions of specialists regarding the agreement with recommendations for prevention and treatment of venous ulcer. Methods: This is a quasi-experimental study with two interventions: provision of studies with the evidence of the recommendations and provision of the opinion of peers, with sample of 73 specialized doctors and nurses. Delphi technique was used in the search for agreement, with three rounds...
May 2017: Revista Brasileira de Enfermagem
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