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https://www.readbyqxmd.com/read/28884048/expression-levels-of-%C3%AE-catenin-and-galectin-3-in-meningioma-and-their-effect-on-brain-invasion-and-recurrence-a-tissue-microarray-study
#1
Rehab Allah Ahmed, Abdelhadi M Shebl, Hany Onsy Habashy
OBJECTIVE: Meningiomas are neoplasms that arise from the meninges of the central nervous system (CNS). They constitute about 25.6% of CNS tumors diagnosed in Egypt. Some morphological variants of meningiomas display aggressive behavior, leading to brain-invasive growth pattern. Although meningiomas are usually treated by complete surgical excision, the risk of postoperative recurrence remains. Hence, additional biomarkers for predicting aggressive behavior must be discovered. This study aims to explore the clinical and biological relevance of the protein expression levels of β-catenin and galectine-3 in meningioma and to understand the pathobiology of this neoplasm...
August 2017: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/28875469/a-panel-of-autoantibodies-against-neural-proteins-as-peripheral-biomarker-for-pesticide-induced-neurotoxicity
#2
Heba Allah Abd El Rahman, Mohamed Salama, Seham A Gad El-Hak, Mona A El-Harouny, Passent ElKafrawy, Mohamed B Abou-Donia
In the present study, we screened the sera of subjects chronically exposed to mixtures of pesticides (composed mainly of organophosphorus compounds (OPs) and others) and developed neurological symptoms for the presence of autoantibodies against cytoskeletal neural proteins. OPs have a well-characterized clinical profile resulting from acute cholinergic crisis. However, some of these compounds cause neuronal degeneration and demyelination known as organophosphorus compound-induced delayed neurotoxicity (OPIDN) and/or organophosphorus compound-induced chronic neurotoxicity (OPICN)...
September 5, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/28846406/ball-and-socket-assembly-of-binary-superatomic-solids-containing-trinuclear-nickel-cluster-cations-and-fulleride-anions
#3
Jessica L Shott, Matthew B Freeman, Nemah-Allah Saleh, Daniel S Jones, Daniel W Paley, Christopher Bejger
The superlattice structures of hierarchical cluster solids are dictated by short-range interactions between constituent building blocks. Here we show that shape complementary sites, as well as halogen and chalcogen bonding between exposed capping ligands and fullerides, govern the packing arrangement of the resulting binary solids. Four new superatomic solids, [Ni3(μ3-I)2(μ2-dppm)3(+)](C60(•-)) (1·C60), [Ni3(μ3-I)2(μ2-dppm)3(+)](C70(-))2 (1·C70), [Ni3(μ3-Te)2(μ2-dppm)3(+)](C60(•-)) (2·C60), and [Ni3(μ3-Te)2(μ2-dppm)3](C70(-))2 (2·C70), (dppm = Ph2PCH2PPh2) were prepared and crystallized from solution...
August 28, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28845718/nurses-experiences-of-grief-following-patient-death-a-qualitative-approach
#4
Inaam A Khalaf, Ghadeer Al-Dweik, Hana Abu-Snieneh, Laila Al-Daken, Ruba M Musallam, Mohammad BaniYounis, Rula Al-Rimawi, Atef Hassan Khatib, Abla Habeeb Allah, Maysoun Hussein Atoum, Arwa Masadeh
PURPOSE: To explore the lived experiences of nurses' feelings, emotions, grief reactions, and coping mechanisms following their patients' death. BACKGROUND: On a daily basis, nurses are experiencing patients' death, which exposes them to grief. Nurses' grief has not been sufficiently addressed in practice settings, although it has been a well-known threat to health and work performance. DESIGN: A qualitative design guided by a phenomenological approach was adopted...
August 1, 2017: Journal of Holistic Nursing: Official Journal of the American Holistic Nurses' Association
https://www.readbyqxmd.com/read/28842213/measles-in-pakistan-time-to-make-steps-towards-eradication
#5
Inayat Ur Rehman, Allah Bukhsh, Tahir Mehmood Khan
World Health Organization (WHO) measles surveillance data report a reduction in cases of measles globally from 67,524 cases in 2015 to 16,846 in 2016, and a reduction in deaths from 546,800 to 114,900 during period of 2000-14. Pakistan is among the five nations where almost a million children did not receive their first dose of measles vaccination, and outbreaks of the disease resulted in 4386 cases in 2011, 14,687 cases in 2012 with 310 deaths. In 2013, about 25,401 cases of measles were reported and 321 affected children died...
August 24, 2017: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/28831818/clinical-pharmacokinetic-study-for-the-effect-of-glimepiride-matrix-tablets-developed-by-quality-by-design-concept
#6
Tarek A Ahmed, Mohammad A A Suhail, Khaled M Hosny, Fathy I Abd-Allah
OBJECTIVE: Implementation of a new pharmaceutical technique to improve aqueous solubility and thus dissolution, enhancement of drug permeation, and finally formulation of a controlled release tablet loaded with glimepiride (GLMP). SIGNIFICANCE: Improve GLMP bioavailability and pharmacokinetics in type II diabetic patients. METHODS: Different polymers were used to enhance aqueous GLMP solubility of which a saturated polymeric drug solution was prepared and physically adsorbed onto silica...
August 23, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28819169/cd206-m2-like-macrophages-regulate-systemic-glucose-metabolism-by-inhibiting-proliferation-of-adipocyte-progenitors
#7
Allah Nawaz, Aminuddin Aminuddin, Tomonobu Kado, Akiko Takikawa, Seiji Yamamoto, Koichi Tsuneyama, Yoshiko Igarashi, Masashi Ikutani, Yasuhiro Nishida, Yoshinori Nagai, Kiyoshi Takatsu, Johji Imura, Masakiyo Sasahara, Yukiko Okazaki, Kohjiro Ueki, Tadashi Okamura, Kumpei Tokuyama, Akira Ando, Michihiro Matsumoto, Hisashi Mori, Takashi Nakagawa, Norihiko Kobayashi, Kumiko Saeki, Isao Usui, Shiho Fujisaka, Kazuyuki Tobe
Adipose tissue resident macrophages have important roles in the maintenance of tissue homeostasis and regulate insulin sensitivity for example by secreting pro-inflammatory or anti-inflammatory cytokines. Here, we show that M2-like macrophages in adipose tissue regulate systemic glucose homeostasis by inhibiting adipocyte progenitor proliferation via the CD206/TGFβ signaling pathway. We show that adipose tissue CD206(+) cells are primarily M2-like macrophages, and ablation of CD206(+) M2-like macrophages improves systemic insulin sensitivity, which was associated with an increased number of smaller adipocytes...
August 18, 2017: Nature Communications
https://www.readbyqxmd.com/read/28807229/tagetones-a-and-b-new-cytotoxic-monocyclic-diterpenoids-from-flowers-of-tagetes-minuta
#8
Sabrin Ragab Mohamed Ibrahim, Gamal Abd Allah Mohamed
Tagetones A (1) and B (2), two new monocyclic diterpenoids were isolated from the n-hexane fraction of fresh flowers of Tagetes minuta L. (Asteraceae). Their structures were established by multiple spectroscopic methods (IR, HR-ESI-MS, and 1D-, and 2D-NMR), in addition to comparison with literature data. Compound 1 showed cytotoxic activity towards MCF7 and A549 cancer cells with IC50 values being 4.68 and 4.24 µmol·L(-1), respectively, compared to doxorubicin (IC50 0.13 and 1.12 µmol·L(-1), respectively)...
July 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28804579/validity-of-prostate-health-index-and-percentage-of-2-pro-prostate-specific-antigen-as-novel-biomarkers-in-the-diagnosis-of-prostate-cancer-omani-tertiary-hospitals-experience
#9
Safana S Al Saidi, Nafila B Al Riyami, Mohammed S Al Marhoon, Mohammed S Al Saraf, Salim S Al Busaidi, Riad Bayoumi, Waad-Allah S Mula-Abed
OBJECTIVES: Prostate cancer is the leading cancer in older men. The Ministry of Health Oman Cancer Incidence Registry 2013 lists cancer of the prostate as the first most common cancer in males. Therefore, early detection is important and prostate-specific antigen (PSA) is widely used as an established laboratory test. However, despite its wide use, its value in screening, particularly in asymptomatic males, is controversial when considering the risks and benefits of early detection. METHODS: This prospective, observational study included 136 males (67...
July 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/28803487/a-mechanism-based-approach-to-management-o-f-children-with-end-stage-liver-disease
#10
Allah B Haafiz
Due to parallel advances in surgical and acute care disciplines, liver transplantation (LT) has revolutionized the outlook for children with end-stage liver disease (ESLD). Contrary to advances in technical aspects of LT and the peri-operative care, pre-transplant management of ESLD remains quite a formidable challenge. Areas covered: This review provides mechanisms based management strategies to address common complications of ESLD including malnutrition, amended metabolic pathways, gastrointestinal dysfunction, and development of ascites...
August 28, 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28764965/atorvastatin-repurposing-for-the-treatment-of-cryptosporidiosis-in%C3%A2-experimentally-immunosuppressed-mice
#11
Noha Madbouly Taha, Hebat-Allah Salah A Yousof, Shaimaa H El-Sayed, Azza Ibrahim Younis, Mohamed Sherif Ismail Negm
The present study was conducted on 200 male mice for the detection of the effect of Atorvastatin on Cryptosporidium spp. infection versus the commercially used drug Nitazoxanide in experimentally immunosuppressed mice. Atorvastatin was used alone at low dose (20 mg/kg), high dose (40 mg/kg), and combined with Nitazoxanide (1000 mg/kg) with either the low dose or high dose for five consecutive days. Parasitological assessment of the drug effect was done using Modified Z-N staining of stool samples collected from mice...
July 29, 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/28757053/cryopreservation-of-indian-red-jungle-fowl-gallus-gallus-murghi-semen-with-polyvinylpyrrolidone
#12
Bushra Allah Rakha, Muhammad Sajjad Ansari, Shamim Akhter, Zartasha Zafar, Iftikhar Hussain, Julian Santiago-Moreno, Elisabeth Blesbois
The Indian red jungle fowl is a sub-species of the genus Gallus native to South Asia; facing high risk of extinction in its native habitat. During cryopreservation, permeable cryoprotectants like glycerol are usually employed and we previously showed encouraging results with 20% glycerol. Because bird spermatozoa contain very little intracellular water, the possibility of replacing an internal cryoprotectant by an external one is opened. In the present study, we tested the replacement of internal cryoprotectant glycerol by the external cryoprotectant Polyvinylpyrrolidone (PVP)...
July 27, 2017: Cryobiology
https://www.readbyqxmd.com/read/28755654/effects-of-bone-marrow-mesenchymal-stem-cells-conditioned-medium-on-tibial-partial-osteotomy-model-of-fracture-healing-in-hypothyroidism-rats
#13
Niloofar Sefati, Mohsen Norouzian, Hojjat-Allah Abbaszadeh, Mohammad-Amin Abdollahifar, Abdollah Amini, Mohammad Bagheri, Arefeh Aryan, Fatemeh Fadaei Fathabady
Background: Hypothyroidism is associated with dysfunction of the bone turnover with reduced osteoblastic bone formation and osteoclastic bone resorption. Mesenchyme stem cells (MSCs) secrete various factors and cytokines that may stimulate bone regeneration. The aim of this study was to determine the effects of MSCs-conditioned medium (CM) in hypothyroidism male rats after inducing bone defect. Methods: : In this study, 24 male rats were randomly assigned to three groups: (I) hypothyroidism+bone defect (HYPO), (II) hypothyroidism+bone defect+CM (HYPO+CM), and (III) no hypothyroidism+bone defect (control)...
July 30, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28749097/lymphoepithelioma-like-carcinoma-of-the-breast-mimicking-granulomatous-mastitis-case-report-and-review-of-the-literature
#14
Dalia M Abouelfad, Noha N Yassen, Hebat Allah A Amin, Marwa E Shabana
Lymphoepithelioma-like carcinoma (LELC) of the breast is an exceedingly rare variant of mammary cancer. To our knowledge, only twenty - one cases have been reported in the literature. Diagnosis of this type of mammary carcinoma may be challenging, owing to its rarity and the histopathological similarity to common inflammatory and malignant lesions of the breast mainly granulomatous mastitis, medullary carcinoma, pleomorphic lobular carcinoma, lymphoma and other hematological malignancies. Our case is the 22nd case of lymphoepithelioma-like carcinoma reported in the breast, presenting with a palpable tender mass in a post-menopausal female...
July 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28734663/mtdna-sequence-diversity-of-hazara-ethnic-group-from-pakistan
#15
Allah Rakha, Fatima, Min-Sheng Peng, Atif Adan, Rui Bi, Memona Yasmin, Yong-Gang Yao
The present study was undertaken to investigate mitochondrial DNA (mtDNA) control region sequences of Hazaras from Pakistan, so as to generate mtDNA reference database for forensic casework in Pakistan and to analyze phylogenetic relationship of this particular ethnic group with geographically proximal populations. Complete mtDNA control region (nt 16024-576) sequences were generated through Sanger Sequencing for 319 Hazara individuals from Quetta, Baluchistan. The population sample set showed a total of 189 distinct haplotypes, belonging mainly to West Eurasian (51...
July 10, 2017: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/28734275/low-level-of-autophagy-related-gene-10-atg10-expression-in-the-6-hydroxydopamine-rat-model-of-parkinson-s-disease
#16
Marzieh Shams Nooraei, Ali Noori-Zadeh, Shahram Darabi, Farzad Rajaei, Zohreh Golmohammadi, Hojjat Allah Abbaszadeh
Background: Autophagy is a mechanism disassembling the damaged organelles from the cell. This study attempted to examine the expression of several autophagy-related genes in Parkinson’s disease (PD) rat model. Methods: The male Wistar rats were divided into three groups as control, sham, and lesion. In the latter group, the PD rat model was induced by the injection of 6-hydroxydopamine in the striatum.The behavioral test was conducted one (baseline) and four weeks after the surgery through apomorphine hydrochloride...
July 23, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28725507/giant-cell-tumor-of-the-capitate-treated-with-excision-and-midcarpal-fusion
#17
Ayat Allah Oufkir, Cyril Lazerges, Bertrand Coulet, Michel Chammas
Background  Giant cell tumor (GCT) of bone is rare in the carpus, and only 11 cases have been reported in the capitate bone. The problem with this location is the high recurrence rate due to easy extension to the adjacent joint spaces and bones. We describe a case of GCT on the capitate bone and the treatment in comparison with the previously reported cases. Case Description  The case report concerns a 48-year-old woman with a GCT of the capitate diagnosed on curettage. The treatment consisted of large resection with the lunatum and third metacarpal arthrodesis, with a successful union at 2 years follow-up, no recurrence, and an improved function of the wrist...
August 2017: Journal of Wrist Surgery
https://www.readbyqxmd.com/read/28717335/evaluation-of-therapeutic-effectiveness-of-prescribed-medications-in-patients-with-type-2-diabetes-mellitus-findings-from-a-tertiary-care-hospital-lahore-pakistan
#18
Bareera Rana, Allah Bukhsh, Tahir Mehmood Khan, Ammar Sarwar, Muhammad Ovais Omer, Shazia Qasim Jamshed
AIM: The present study was aimed to highlight the current prescribing pattern of oral hypoglycemia in type 2 diabetes mellitus and to evaluate the therapeutic effectiveness of these therapeutic categories in achieving target glycemic control. METHODS: This is a prospective, cross-sectional, observational study of 6 months' duration conducted in a tertiary care hospital of Lahore, Pakistan. RESULTS: The current research recruited 145 patients presented in diabetes management center of a tertiary care hospital in Lahore, Pakistan...
April 2017: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/28712172/laparoscopic-sleeve-gastrectomy-a-prospective-follow-up-of-30-patients
#19
Asad Ali Toor, Muhammad Waris Farooka, Mahmood Ayyaz, Zeeshan Razzaq, Awais Amjad Malik, Allah Nawaz, Asif Mahmood, Henry Paul Redmond
BACKGROUND: Morbid obesity has become a surgically treatable problem. Laparoscopic sleeve gastrectomy is becoming a popular choice both for surgeons and patients due to effectiveness and low complication rates. METHODS: It was a prospective case series spanning over 6 years. Patient enrolment started from January 2009 and data collection completed in January 2015. Patient with BMI (weight in kilogram/height in meter square) of more than 35 were included in the study...
January 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28706241/abnormal-paraventricular-nucleus-of-hypothalamus-and-growth-retardation-associated-with-loss-of-nuclear-receptor-gene-coup-tfii
#20
Su Feng, Can Xing, Tingyu Shen, Yunbo Qiao, Ran Wang, Jun Chen, Jiaoyang Liao, Zhuo Lu, Xiong Yang, Saber Mohamed Abd-Allah, Jinsong Li, Naihe Jing, Ke Tang
The paraventricular nucleus of hypothalamus plays important roles in the regulation of energy balance and fetal growth. However, the molecular mechanisms underlying its formation and function have not been clearly elucidated. Various mutations in the human COUP-TFII gene, which encodes a nuclear receptor, result in growth retardation, congenital diaphragmatic hernia and congenital heart defects. Here, we show that COUP-TFII gene is expressed in the developing hypothalamus in mouse. The ventral forebrain-specific RXCre/+; COUP-TFII (F/F) mutant mice display growth retardation...
July 13, 2017: Scientific Reports
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