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https://www.readbyqxmd.com/read/29341212/differential-role-of-pten-in-transforming-growth-factor-%C3%AE-tgf-%C3%AE-effects-on-proliferation-and-migration-in-prostate-cancer-cells
#1
Mawiyah N Kimbrough-Allah, Ana C Millena, Shafiq A Khan
BACKGROUND: Transforming growth factor-β (TGF-β) acts as a tumor suppressor in normal epithelial cells but as a tumor promoter in advanced prostate cancer cells. PI3-kinase pathway mediates TGF-β effects on prostate cancer cell migration and invasion. PTEN inhibits PI3-kinase pathway and is frequently mutated in prostate cancers. We investigated possible role(s) of PTEN in TGF-β effects on proliferation and migration in prostate cancer cells. METHODS: Expression of PTEN mRNA and proteins were determined using RT-PCR and Western blotting in RWPE1 and DU145 cells...
January 16, 2018: Prostate
https://www.readbyqxmd.com/read/29334205/overexpression-of-endometrial-estrogen-receptor-alpha-in-the-window-of-implantation-in-women-with-unexplained-infertility
#2
Mehran Dorostghoal, Hamid-O-Allah Ghaffari, Farideh Marmazi, Narjes Keikhah
Background: Failure in the endometrial receptivity may account for a significant number of infertility cases including unexplained infertility in women. Reduction in the endometrial estrogen receptor-alpha (ER-α) expression during implantation may be a critical event that coincides with the expression of specific genes and the formation of a receptive endometrium. The aim of the present study was to assess the expression of ER-α in the mid-secretory phase in the endometrium of women with unexplained infertility...
April 2018: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/29333939/parents-attitude-awareness-and-behaviour-towards-influenza-vaccination-in-pakistan
#3
Allah Bukhsh, Habib-Ur Rehman, Inayat Ur Rehman, Tahir Mehmood Khan, Tauqeer Hussain Mallhi
National immunization program of Pakistan does not include Influenza vaccines. The low rate of immunization might be attributed to the poor knowledge of influenza vaccination in Pakistan. Current study was aimed to assess the knowledge and attitude of influenza vaccination among parents. A questionnaire-based cross sectional study was conducted among randomly selected parents with at least one child aged >6 months. The responses were recorded against 27 items questionnaire assessing knowledge, perception, attitude and behaviours of parents...
January 15, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29329106/genetic-mutations-associated-with-neonatal-diabetes-mellitus-in-omani-patients
#4
Aisha Al Senani, Nishath Hamza, Hanan Al Azkawi, Manal Al Kharusi, Nashat Al Sukaiti, Maryam Al Badi, Moza Al Yahyai, Matthew Johnson, Elisa De Franco, Sarah Flanagan, Andrew Hattersley, Sian Ellard, Waad-Allah Mula-Abed
BACKGROUND: Neonatal diabetes mellitus (NDM) is a rare disorder worldwide where diabetes is diagnosed in the first 6 months of life. However, Oman has a relatively high incidence of NDM. METHODS: In this study, we investigated the genetic etiologies underlying NDM and their prevalence in Oman. We collected a cohort of 24 NDM patients, with and without genetic diagnosis, referred to our center from 2007 to 2015. All patients without a genetic diagnosis were tested for mutations in 23 NDM-associated genes using a custom-targeted next-generation sequencing (NGS) panel and methylation analysis of the 6q24 locus...
January 12, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29307157/the-effect-of-vestibular-rehabilitation-therapy-program-on-sensory-organization-of-deaf-children-with-bilateral-vestibular-dysfunction
#5
Amir Abbas Ebrahimi, Ali Ashraf Jamshidi, Guita Movallali, Mehdi Rahgozar, Hojjat Allah Haghgoo
The purpose of this study was to determine the effect of vestibular rehabilitation therapy program on the sensory organization of deaf children with bilateral vestibular dysfunction. This cross-sectional and analytic study was conducted on 24 students between the age of 7 and 12 years (6 girls and 18 boys) with the profound sensorineural hearing loss (PTA>90 dB). They were assessed through the balance subtest in Bruininks-Oseretsky test of motor proficiency (BOTMP). For children which the total score of the balance subtest was 3 standard deviation lower than their peers with typical development, vestibular function testing was completed pre-intervention...
November 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/29258372/stroke-burden-in-egypt-data-from-five-epidemiological-studies
#6
Foad Abd-Allah, Eman Khedr, Mohammed I Oraby, Ahmed Safwat Bedair, Shady Samy Georgy, Ramez Reda Moustafa
OBJECTIVES: Accurate data on the epidemiology of stroke in Egypt is scarce. The aim of this review is to address this issue based on available community-based studies and compare the resulting findings to those of other regional and international studies. METHOD: A systematic literature search was conducted to identify population-based epidemiological studies of stroke in Egyptians. Original articles published in English between 1990 and 2016 were included. Five studies from 5 different governorates in southern Egypt fulfilled the study criteria (Qena, Sohag, Assiut, New Valley and Red Sea)...
December 19, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/29258367/evaluation-of-prolonged-use-of-statins-on-the-clinical-and-biochemical-abnormalities-and-ovulation-dysfunction-in-single-young-women-with-polycystic-ovary-syndrome
#7
Emaduldin Seyam, Saad Al Gelany, Ahmed Abd Al Ghaney, Marwa Abd Allah Mohamed, Ayman Moheb Youseff, Emad Moussa Ibrahim, Eissa M Khalifa, Enas Hefzy
OBJECTIVE: The aim of the current work was to investigate the effects of prolonged use of Statins on the clinical and biochemical abnormalities and ovulation dysfunction in young single women with polycystic ovary syndrome (PCOS). PATIENTS AND METHODS: It was a randomized, double-blind, placebo-controlled study. Where 200 single young women with PCOS were randomized into either 100 (n = 100) women using Simvastatin 20 mg daily considered as group A (study group), or 100 (n = 100) women using placebo and considered as group B (control group), for six months treatment period...
December 19, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29249376/public-stroke-knowledge-awareness-and-response-to-acute-stroke-multi-center-study-from-4-egyptian-governorates
#8
Mohammad A Farrag, Mohammed I Oraby, Azza A Ghali, Osama A Ragab, Ahmed Nasreldein, Ghaydaa A Shehata, Eman Elfar, Foad Abd-Allah
BACKGROUND AND PURPOSE: Acute stroke treatment has significantly improved over the years in Egypt. However, there is often notable delay in pre-hospital and in-hospital management of acute stroke patients. The delay may be largely attributed to poor stroke knowledge and awareness of the general public and this study was aimed at the evaluation of the abovementioned factors. METHODS: Descriptive cross-sectional study involving 1154 participants from 4 governorates using a questionnaire in Arabic, collecting sociodemographic data, participants' risk factors, and knowledge and stroke awareness (risk factors, symptoms, prevention, treatment and prognosis, action in response to acute stroke)...
January 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29242974/effect-of-intramural-fibroid-on-uterine-and-endometrial-vascularity-in-infertile-women-scheduled-for-in-vitro-fertilization
#9
Ahmed Kamel, Akmal El-Mazny, Wafaa Ramadan, Suzy Abdelaziz, Sherine Gad-Allah, Hany Saad, Ahmed M Hussein, Emad Salah
PURPOSE: To study the effect of intramural fibroids on uterine and endometrial vascularity in infertile women scheduled for in-vitro fertilization (IVF). METHODS: 3D power Doppler was used to measure the endometrial volume and blood flow indices in 182 women with intramural fibroids not affecting the uterine cavity and compared them to a matched control group without fibroids. RESULTS: There was significantly increased vascularity in the endometrium of the fibroid group as denoted by higher endometrial VI (p = 0...
December 14, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29230230/comparative-performance-of-ground-vs-aerially-assessed-rgb-and-multispectral-indices-for-early-growth-evaluation-of-maize-performance-under-phosphorus-fertilization
#10
Adrian Gracia-Romero, Shawn C Kefauver, Omar Vergara-Díaz, Mainassara A Zaman-Allah, Boddupalli M Prasanna, Jill E Cairns, José L Araus
Low soil fertility is one of the factors most limiting agricultural production, with phosphorus deficiency being among the main factors, particularly in developing countries. To deal with such environmental constraints, remote sensing measurements can be used to rapidly assess crop performance and to phenotype a large number of plots in a rapid and cost-effective way. We evaluated the performance of a set of remote sensing indices derived from Red-Green-Blue (RGB) images and multispectral (visible and infrared) data as phenotypic traits and crop monitoring tools for early assessment of maize performance under phosphorus fertilization...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29223450/pesticide-degrading-natural-multidrug-resistance-bacterial-flora
#11
REVIEW
Kirubakaran Rangasamy, Murugan Athiappan, Natarajan Devarajan, Gopinath Samykannu, Javid A Parray, K N Aruljothi, Nowsheen Shameem, Abdulaziz A Alqarawi, Abeer Hashem, Elsayed Fathi Abd Allah
Multidrug-resistant (MDR) bacteria are a growing threat to humans across the world. Antibiotic resistance is a global problem that has developed through continuous antibiotic use, combinatorial antibiotic use, pesticide-antibiotic cross-resistance, and horizontal gene transfer, as well as various other modes. Pesticide-antibiotic cross-resistance and the subsequent expansion of drug-resistant bacteria are critically documented in this review, the primary focus of which is to assess the impact of indiscriminate pesticide use on the development of microbial communities with parallel pesticide and multidrug resistance...
December 6, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29219625/utility-of-point-shear-wave-elastography-in-characterisation-of-focal-liver-lesions
#12
Maha Hasab-Allah, Rabab Mamoun Salama, Mohamed Saeed Marie, Ahmed Alsaeed Mohammed Mandur, Heba Omar
No abstract text is available yet for this article.
December 8, 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29208173/transforming-growth-factor-%C3%AE-1-gene-polymorphism-and-osteoporosis-in-postmenopausal-egyptian-women
#13
Inass M Taha, Azza M Abdu Allah, Maha A F Hamoudah, S Justin Carlus
Transforming growth factor-β1 (TGF-β1) is a wide spread bone matrix protein that affect the function, formation and cell-cell interactions of osteoclasts and osteoblasts to regulate bone remodeling and sustain adequate bone mass. The aim of this study is to evaluate the role of the two polymorphism of transforming growth factor-β1 T869C and C-509T in developing osteoporosis in postmenopausal Egyptian women. This study was performed on 138 postmenopausal osteoporosis/osteopenic women and 128 postmenopausal female control group...
November 30, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/29206666/immediate-effects-of-simultaneous-application-of-transcutaneous-electrical-nerve-stimulation-and-ultrasound-phonophoresis-on-active-myofascial-trigger-points-a-randomized-controlled-trial
#14
Mary Kamal Nassif Takla, Soheir Shethata Rezk-Allah Rezk
OBJECTIVE: was to investigate the efficacy of phonophoresis with combined therapy (PH-CT) on active myofascial trigger points (MTrPs). PARTICIPANTS: One hundred participants with acute mechanical neck pain and at least one active MTrP in the upper trapezius were randomly assigned into 4 equal groups. INTERVENTION: Groups consisted of; diclofenac PH-CT; diclofenac phonophoresis (PH); ultrasound (US) with coupling gel and sham-US; applied for 10 minutes over MTrP...
December 5, 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/29201123/the-effect-of-kinesio-taping-on-handgrip-and-active-range-of-motion-of-hand-in-children-with-cerebral-palsy
#15
Zabih Allah RASTIl, Alireza Shamsoddini, Hamid Dalvand, Sina Labaf
Objective: Kinesio taping is a relatively new technique, which uses in rehabilitation of neurologic diseases. The aim of this study was to investigate the effects of Kinesio taping on hand grip and active range of motion of hand in children with cerebral palsy (CP). Materials and Methods: In this experimental study with pre-test and three post-tests, 32 children with CP randomly were placed in experimental (n=17) and control group (n=15).Kinesio taping was applied on dorsum of forearm and hand...
2017: Iranian Journal of Child Neurology
https://www.readbyqxmd.com/read/29197956/comparative-effects-of-biochar-slag-and-ferrous-mn-ore-on-lead-and-cadmium-immobilization-in-soil
#16
Sajid Mehmood, Muhammad Rizwan, Saqib Bashir, Allah Ditta, Omar Aziz, Li Zhe Yong, Zhihua Dai, Muhammad Akmal, Waqas Ahmed, Muhammad Adeel, Muhammad Imtiaz, Shuxin Tu
A variety of remediation approaches have been applied to the heavy metals-contaminated soils, however, the immobilization of metals in co-contaminated soils still not cleared. Therefore, an incubation study was conducted to evaluate the instantaneous effects of different concentrations of biochar (BC), slag (SL) and Fe-Mn ore (FMO) on immobilization of Pb and Cd through the Toxicity Characteristic Leaching Procedure (TCLP) by following the the European Community Bureau of Reference (BCR), CaCl2 and NH4NO3. The sequential extraction of BCR showed decrease in acid soluble fractions, while the residual proportions of Pb and Cd were enhanced with increasing concentrations of SL and BC...
December 2, 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/29187735/mitochondrial-genomes-uncover-the-maternal-history-of-the-pamir-populations
#17
Min-Sheng Peng, Weifang Xu, Jiao-Jiao Song, Xing Chen, Xierzhatijiang Sulaiman, Liuhong Cai, He-Qun Liu, Shi-Fang Wu, Yun Gao, Najmudinov Tojiddin Abdulloevich, Manilova Elena Afanasevna, Khudoidodov Behruz Ibrohimovich, Xi Chen, Wei-Kang Yang, Miao Wu, Gui-Mei Li, Xing-Yan Yang, Allah Rakha, Yong-Gang Yao, Halmurat Upur, Ya-Ping Zhang
The Pamirs, among the world's highest mountains in Central Asia, are one of homelands with the most extreme high altitude for several ethnic groups. The settlement history of modern humans on the Pamirs remains still opaque. Herein, we have sequenced the mitochondrial DNA (mtDNA) genomes of 382 individuals belonging to eight populations from the Pamirs and the surrounding lowlands in Central Asia. We construct the Central Asian (including both highlanders and lowlanders) mtDNA haplogroup tree at the highest resolution...
November 29, 2017: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/29186028/responsive-proteins-in-wheat-cultivars-with-contrasting-nitrogen-efficiencies-under-the-combined-stress-of-high-temperature-and-low-nitrogen
#18
Peerzada Yasir Yousuf, Elsayed Fathi Abd Allah, Mohd Nauman, Ambreen Asif, Abeer Hashem, Abdulaziz A Alqarawi, Altaf Ahmad
Productivity of wheat (Triticumaestivum) is markedly affected by high temperature and nitrogen deficiency. Identifying the functional proteins produced in response to these multiple stresses acting in a coordinated manner can help in developing tolerance in the crop. In this study, two wheat cultivars with contrasting nitrogen efficiencies (N-efficient VL616 and N-inefficient UP2382) were grown in control conditions, and under a combined stress of high temperature (32 °C) and low nitrogen (4 mM), and their leaf proteins were analysed in order to identify the responsive proteins...
November 29, 2017: Genes
https://www.readbyqxmd.com/read/29182986/amelioration-of-cadmium-induced-testes-damage-in-rats-by-the-bone-marrow-mesenchymal-stem-cells
#19
Heba Allah M Elbaghdady, Maha A Alwaili, Reda S El-Demerdash
Cadmium (Cd) and its compounds are highly toxic to virtually all organ systems of the mammals. Cd-induced testicular injuries have been reported in various animal species, using different protocols. The self-renewal capacity and the ability to generate different specialized cell types make the mesenchymal stem cells (MSCs) one of the ideal choices for restoring tissue damages of various etiologies. The use of bone marrow-derived MSCs (BM-MSCs) is among the most recent strategies to repair the Cd-induced testicular damage, but empirical studies in this regard are largely missing...
November 25, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29175802/review-ethnomedicinal-phytochemical-and-antibacterial-activities-of-medicinal-flora-of-pakistan-used-against-pseudomonas-aeruginosa-a-review
#20
Roqaia Bibi, Akash Tariq, Sakina Mussarat, Shahid Niaz Khan, Hazir Rahman, Elsayed Fathi Abd Allah, Riaz Ullah, Muhammad Adnan
Medicinal plants have been used from ancient time against different infectious diseases caused by microorganisms across the globe. The present review represents different medicinal plants of Pakistan used traditionally for the treatment of variety of ailments caused by Pseudomonas aeruginosa, their in-vitro activities against P. aeruginosa and phytochemistry. These plants were extracted with different solvents that showed good in-vitro activities against P. aeruginosa, due to the presence of active phytoconstituents including alkaloids, terpenoids etc...
November 2017: Pakistan Journal of Pharmaceutical Sciences
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