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Yugal Kishore Mohanta, Debasis Nayak, Kunal Biswas, Sameer Kumar Singdevsachan, Elsayed Fathi Abd Allah, Abeer Hashem, Abdulaziz A Alqarawi, Dhananjay Yadav, Tapan Kumar Mohanta
The present study demonstrates an economical and eco-friendly method for the synthesis of silver nanoparticles (AgNPs) using the wild mushroom Ganoderma sessiliforme . The synthesis of AgNPs was confirmed and the products characterized by UV-visible spectroscopy, dynamic light scattering spectroscopy and X-ray diffraction analysis. Furthermore, Fourier transform infrared spectroscopy (ATR-FTIR) analysis was performed to identify the viable biomolecules involved in the capping and active stabilization of AgNPs...
March 14, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Hirokazu Sadahiro, Kyung-Don Kang, Justin T Gibson, Mutsuko Minata, Hai Yu, Junfeng Shi, Rishi Raj Chhipa, Zhihong Chen, Songjia Lu, Yannick Simoni, Takuya Furuta, Hemragul Sabit, Suojun Zhang, Soniya Bastola, Shinobu Yamaguchi, Heba Allah Alsheikh, Svetlana Komarova, Jun Wang, Sung-Hak Kim, Dolores Hambardzumyan, Xinghua Lu, Evan W Newell, Biplab Dasgupta, Mitsutoshi Nakada, Ly James Lee, Louis B Nabors, Lyse A Norian, Ichiro Nakano
Glioblastoma (GBM) is a lethal disease with no effective therapies available. We previously observed upregulation of the TAM (Tyro-3, Axl, and Mer) receptor tyrosine kinase family member AXL in mesenchymal GBM and showed that knockdown of AXL induced apoptosis of mesenchymal, but not proneural, glioma sphere cultures (GSC). In this study, we report that BGB324, a novel small molecule inhibitor of AXL, prolongs the survival of immunocompromised mice bearing GSC-derived mesenchymal GBM-like tumors. We show that protein S (PROS1), a known ligand of other TAM receptors, was secreted by tumor-associated macrophages/microglia and subsequently physically associated with and activated AXL in mesenchymal GSC...
March 12, 2018: Cancer Research
K A Bawa-Allah, J K Saliu, A A Otitoloju
This comparative analysis was carried out to monitor heavy metal concentrations in the Lagos Lagoon over the last 2 decades. Surface water and sediment samples were collected from stations on the Lagos Lagoon based on their suitability for comparative analysis and future monitoring. Heavy metal content in samples was determined using Flame atomic absorption spectrophotometry (FAAS). The concentrations in the samples were compared to those obtained by Don-Pedro et al. (West African Journal of Applied Ecology 5:103-114, 2004) in previous studies from the same sampling zones...
March 8, 2018: Bulletin of Environmental Contamination and Toxicology
Javid A Parray, Azra N Kamili, Sumira Jan, Mohammad Yaseen Mir, Nowsheen Shameem, Bashir A Ganai, Elsayed Fathi Abd Allah, Abeer Hashem, Abdulaziz A Alqarawi
Arnebia benthamii of the family Boraginaceae is a critically endangered nonendemic plant of the Kashmir Himalayas and is used to treat a number of human diseases. The current study was based on developing an in vitro micropropagation protocol vis-à-vis induction of various secondary metabolites under in vitro conditions for the possible biological activity. A tissue culture protocol was developed for A. benthamii for the first time in the Himalayan region using varied combinations and proper media formulations, including various adjuvants: Murashige and Skoog (MS) media, growth hormones, sugars, agar, and so forth...
2018: BioMed Research International
Aubid Allah Khan, Naveed Akhtar, Asadullah Madni, Nayab Tahir, Mubashar Rehman, Ahmed Raza, Aurangzeb Qadir
Tuberculosis (TB) is an infectious disease that is communicable from one person to another. Pakistan stands forefront among few unfortunate countries that still have heavy burden of TB infection. Being a developing country, TB patients in Pakistan have to face different socio-economic constraints that upset life of the patients as well as their families. A cross sectional survey was conducted in three selected districts, Lodharan, Bahawalpur and Bahawalnagar during February 2011 to June 2011. From three hundred selected patients 210 Were enrolled in study after receiving written consents...
May 2017: Acta Poloniae Pharmaceutica
Hebat-Allah S Abbas, Somaia S Abd El-Karim, Nayera A M Abdelwahed
The present study investigates, the synthesis of new derivatives of benzenesulfonamide nucleus hybridized with various substituted pyrazole 4, 8 and thiazole ring 6 using 4-amino-N-butylbenzenesulfonamide 1 as the key starting compound. Furthermore, 3,5-diaminopyrazole derivative 10 was allowed to react with different reagents such as an active methylene compounds, ketone dithioacetal, ethoxymethylene malononitrile and cyanoguanidine for a preparation of new benzenesulfonamide derivatives 11-18 conjugated with different substituted hetero-bicyclic ring systems...
May 2017: Acta Poloniae Pharmaceutica
Mahmoud Hashemi Tabar, Mohammad Reza Tabandeh, Eskandar Moghimipour, Dian Dayer, Ata A Ghadiri, Elham Allah Bakhshi, Mahmoud Orazizadeh, Mohammad Ali Ghafari
Pancreatic and duodenal homeobox 1 (Pdx1) and Sonic hedgehog (Shh) are the key regulators of beta-cell function. In vitro experiments have shown that there is significant cooperation between Pdx1 and Shh with regard to the production and maintenance of insulin-producing cells (IPCs). In this study, the combined effect of Pdx1 overexpression and Shh manipulation on the function of adipose tissue-derived IPCs was determined. A eukaryotic expression vector ( Pdx1- pCDNA3.1(+)) was constructed and transfected into a Chinese hamster ovary (CHO) cell line...
March 2018: FEBS Open Bio
Asad Nawaz, Allah Bakhsh Javaid, Sana Irshad, Seyed Hossein Hoseinifar, Hanguo Xiong
The gut immune system is, the main option for maintaining host's health, affected by numerous factors comprising dietary constituents and commensal bacteria. These dietary components that affect the intestinal immunity and considered as an alternative of antibiotics are called immunosaccharides. Fructooligosaccharide (FOS), Galactooligosaccharide (GOS), inulin, dietary carbohydrates, and xylooligosaccharide (XOS) are among the most studied prebiotics in human as well as in aquaculture. Although prebiotics and probiotics have revealed potential as treatment for numerous illnesses in both human and fish, a comprehensive understanding of the molecular mechanism behind direct and indirect effect on the intestinal immune response will help more and perhaps extra effective therapy intended for ailments...
March 3, 2018: Fish & Shellfish Immunology
Atif Adnan, Xiaoni Zhan, Kadirya Kasim, Allah Rakha, Xing Jia Xin
Forensic statistical parameters based on allelic frequencies of commonly used short tandem repeats were estimated for the Han population of Jiangsu province from P.R. China. The 6-dye GlobalFiler™ PCR amplification kit incorporates 21 autosomal STRs, providing reliable DNA typing results with enhanced the power of discrimination. Here, we analyzed the GlobalFiler™ STR loci in 516 unrelated individuals from Jiangsu Han population. A total of 256 alleles were observed ranging between 5 and 35.2 repeat units, and SE33 showed the greatest power of discrimination (34 alleles) in Jiangsu Han population...
March 2, 2018: International Journal of Legal Medicine
Samir A Salama, Hany H Arab, Hany A Omar, Hesham S Gad, Gamil M Abd-Allah, Ibrahim A Maghrabi, Majed M Al Robaian
UVA comprises more than 90% of the solar UV radiation reaching the Earth. Artificial lightening lamps have also been reported to emit significant amounts of UVA. Exposure to UVA has been associated with dermatological disorders including skin cancer. At the molecular level, UVA damages different cellular biomolecules and triggers inflammatory responses. The current study was devoted to investigate the potential protective effect of L-carnitine against UVA-induced skin tissue injury using rats as a mammalian model...
February 27, 2018: Chemico-biological Interactions
Hanifeh Erie, Hami Kaboosi, Naeme Javid, Hesamaddin Shirzad-Aski, Masoumeh Taziki, Maya Babaee Kuchaksaraee, Ezzat Allah Ghaemi
Background and Objectives: Tuberculosis (TB) is still responsible for a wide range of deaths worldwide. Beijing genotype is one of the most important and virulent strains in Mycobacterium tuberculosis . This study was designed for determination Beijing genotypes of M. tuberculosis in Golestan province, north of Iran. Materials and Methods: In the current descriptive study, 238 clinical MTB isolates, obtained from patients with pulmonary and extra-pulmonary TB in north of Iran, were evaluated...
December 2017: Iranian Journal of Microbiology
Muayyad M Ahmad, Ruba Musallam, Abla Habeeb Allah, Laila Al-Daken, Hana Abu-Snieneh, Ghadeer Al-Dweik
Objective: This study aimed to evaluate the maturity level of stigma as a concept in nursing and its relationship to care provided for patients with cancer. Methods: The four principles of Morse and his colleagues were used to evaluate the maturity level of the stigma concept: epistemological, logical, pragmaticl, and linguistic. Analysis was conducted with the literature published between 2006 and 2016. Results: The findings of this study suggest that the concept of stigma in nursing is immature, defined inconsistently, and measured with different instruments...
February 26, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Mehrez E El-Naggar, Emad K Radwan, Shaimaa T El-Wakeel, Hany Kafafy, Tarek A Gad-Allah, Amer S El-Kalliny, Tharwat I Shaheen
Recently, naturally occurring biopolymers have attracted the attention as potential adsorbents for the removal of water contaminants. In this work, we present the development of microcrystalline cellulose (MCC)-based nanogel grafted with acrylamide and acrylic acid in the presence of methylene bisacrylamide and potassium persulphate as a crosslinking agent and initiator, respectively. World-class facilities such as X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), surface analysis, field emission scanning electron microscopy (FE-SEM), high resolution transmission electron microscopy (HR-TEM) and zeta sizer were used to characterize the synthesized MCC based nanogel...
February 21, 2018: International Journal of Biological Macromolecules
Kifayat Ullah Khan, Maqarab Shah, Habib Ahmad, Shujaul Mulk Khan, Inayat Ur Rahman, Zafar Iqbal, Raees Khan, Elsayed Fathi Abd Allah, Abdulaziz Abdullah Alqarawi, Abeer Hashem, Abdullah Aldubise
In the study area, the traditional knowledge regarding the uses of local wild medicinal plants for the health care of human and domestic animals is totally in hold of old people. The young ones are unaware about such an indispensable practices. The objective of the current study was to transfer this sort of precious knowledge from old members of the community to young generations in documented form.
February 2018: Saudi Journal of Biological Sciences
Mohammed A Kassem, Mohamed A Megahed, Sherif K Abu Elyazid, Fathy I Abd-Allah, Tamer M Abdelghany, Ahmed M Al-Abd, Khalid M El-Say
Serious adverse effects and low selectivity to cancer cells are the main obstacles of long term therapy with Tamoxifen (Tmx). This study aimed to develop Tmx-loaded span-based nano-vesicles for delivery to malignant tissues with maximum efficacy. The effect of three variables on vesicle size (Y1 ), zeta potential (Y2 ), entrapment efficiency (Y3 ) and the cumulative percent release after 24 h (Y4 ) were optimized using Box-Behnken design. The optimized formula was prepared and tested for its stability in different storage conditions...
February 22, 2018: AAPS PharmSciTech
Judith Didi-Kouko Coulibaly, Mireille Yeboua, Alphonsine Kouassi Mbengue, Emile Allah Kouadio, Henriette Anzouan-Kacou Kissi, Allah Yves-Omer Binan, Marie-Jeanne Lohoues Kouacou, Alain Attia, Dowlo N'dri Athanase Yao, Toussaint Toutou, Innocent Adoubi, Pascal Pineau
No abstract text is available yet for this article.
February 16, 2018: Bulletin du Cancer
Azza M Abdu Allah, Sally M El-Hefnway, Alshimaa M Alhanafy, Ahmed M Zahran, Heba E Kasem
Leptin plays an important role in carcinogenesis as leptin/leptin receptor signaling promotes the angiogenesis, proliferation, and inhibits epithelial cell apoptosis. Variants in the leptin receptor gene have potential associations with renal cell carcinoma (RCC). We aimed to investigate association of rs1137101 (A/G) polymorphism at LEPR gene with risk of RCC and patients survival. 123 individuals were classified into group I: 73 RCC patients and group II: 50 healthy controls. Genotyping of the Gln223Arg (A/G) polymorphism rs1137101 at LEPR gene was analyzed using allelic discrimination assay by Real-Time PCR technique...
February 16, 2018: Molecular and Cellular Biochemistry
Ali Asghar Peyvandi, Navid Ahmady Roozbahany, Hassan Peyvandi, Hojjat-Allah Abbaszadeh, Niloofar Majdinasab, Mohammad Faridan, Somayeh Niknazar
Previous animal studies have shown that stromal cell-derived factor-1 (SDF-1)/CXC chemokine receptor-4 (CXCR4) signaling pathway plays an important role in the targeted migration of bone marrow-derived mesenchymal stem cells (BMSCs) to the injured area. In the present study, we aimed to investigate the potential role of chemotactic SDF-1/CXCR4 signaling pathway in the homing of transplanted BMSCs to the injured cochlea after noise-induced hearing loss (NIHL) in a rat model. White noise exposure (110 dB) paradigm was used for hearing loss induction in male rats for 6 hours in 5 days...
January 2018: Neural Regeneration Research
Amin Allah Dashtiyan, Masood Sepehrimanesh, Nader Tanideh, Mohammad Esmaeil Afzalpour
The aim of this study was to investigate the effect of endurance training with and without vitamin E on the expression of p53 and Phosphatase and tension homolog (PTEN) tumor suppressor genes of prostate glands in male rats. For this purpose, 50 Sprague-Dawley male rats were randomly assigned into 5 groups: (1) control group (CON, n = 10), (2) sham (S, n = 10), (3) endurance training (ET, n = 10), (4) endurance training + vitamin E (ET + VE, n = 10), (5) vitamin E (VE, n = 10). Endurance training protocol was implemented for 6 weeks, 6 days per week, in accordance with the overload principle...
June 2017: Biochimie open
Ahmad Sher, Muhammad Suleman, Abdul Qayyum, Abdul Sattar, Allah Wasaya, Muhammad Ijaz, Ahmad Nawaz
Sunflower (Helianthus annuus L.) is a major oilseed crop grown for its edible oil across the globe including Pakistan. In Pakistan, the production of edible oil is less than the required quantity; the situation is being worsened with the increasing population. Thus, there is dire need to grow those sunflower genotypes which perform better under a given set of agronomic practices. In this 2-year study, we compared four sunflower genotypes, viz., Armoni, Kundi, Sinji, and S-278 for their yield potential, oil contents, fatty acid composition, and profitability under three sowing methods, viz...
February 14, 2018: Environmental Science and Pollution Research International
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