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https://www.readbyqxmd.com/read/27933736/structural-insight-into-the-anti-prion-compound-inhibition-mechanism-of-native-prion-folding-over-misfolding
#1
Jiwon Choi, Rajiv Gandhi Govindaraj, Jae Wook Hyeon, Kyungro Lee, SongLing Ma, Su Yeon Kim, Jeongmin Lee, Kyoung Tai No
Transition of a physiological folded prion (PrP(C) ) into a pathogenic misfolded prion (PrP(S)(c) ) causes lethal neurodegenerative disorders and prion diseases. Anti-prion compounds have been developed to prevent this conversion; however, their mechanism of action remains unclear. Recently, we reported two anti-prion compounds, BMD29 and 35, identified by in silico and in vitro screening. In this study, we used extensive explicit-solvent molecular dynamics simulations to investigate ligand binding inhibition by anti-prion compounds in prion folding over misfolding behavior at acidic pH...
December 9, 2016: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/27929018/greenland-was-nearly-ice-free-for-extended-periods-during-the-pleistocene
#2
Joerg M Schaefer, Robert C Finkel, Greg Balco, Richard B Alley, Marc W Caffee, Jason P Briner, Nicolas E Young, Anthony J Gow, Roseanne Schwartz
The Greenland Ice Sheet (GIS) contains the equivalent of 7.4 metres of global sea-level rise. Its stability in our warming climate is therefore a pressing concern. However, the sparse proxy evidence of the palaeo-stability of the GIS means that its history is controversial (compare refs 2 and 3 to ref. 4). Here we show that Greenland was deglaciated for extended periods during the Pleistocene epoch (from 2.6 million years ago to 11,700 years ago), based on new measurements of cosmic-ray-produced beryllium and aluminium isotopes ((10)Be and (26)Al) in a bedrock core from beneath an ice core near the GIS summit...
December 7, 2016: Nature
https://www.readbyqxmd.com/read/27928609/characterization-of-phthalocyanine-functionalized-quantum-dots-by-dynamic-light-scattering-laser-doppler-and-capillary-electrophoresis
#3
Gonzalo Ramírez-García, David O Oluwole, Siphesihle Robin Nxele, Fanny d'Orlyé, Tebello Nyokong, Fethi Bedioui, Anne Varenne
In this work, we characterized different phtalocyanine-capped core/shell/shell quantum dots (QDs) in terms of stability, ζ-potential, and size at various pH and ionic strengths, by means of capillary electrophoresis (CE), and compared these results to the ones obtained by laser Doppler electrophoresis (LDE) and dynamic light scattering (DLS). The effect of the phthalocyanine metallic center (Zn, Al, or In), the number (one or four), and nature of substituents (carboxyphenoxy- or sulfonated-) of functionalization on the phthalocyanine physicochemical properties were evaluated...
December 7, 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27926995/frozen-but-no-accident-why-the-20-standard-amino-acids-were-selected
#4
REVIEW
Andrew J Doig
The 20 standard amino acids encoded by the Genetic Code were adopted during the RNA World, around 4 billion years ago. This amino acid set could be regarded as a frozen accident, implying that other possible structures could equally well have been chosen to use in proteins. Amino acids were not primarily selected for their ability to support catalysis, since the RNA World already had highly effective cofactors to perform reactions, such as oxidation, reduction and transfer of small molecules. Rather, they were selected to enable the formation of soluble structures with close-packed cores, allowing the presence of ordered binding pockets...
December 7, 2016: FEBS Journal
https://www.readbyqxmd.com/read/27924927/enhanced-cycling-stability-of-nico2s4-nio-core-shell-nanowire-arrays-for-all-solid-state-asymmetric-supercapacitors
#5
Yuanyuan Huang, Tielin Shi, Shulan Jiang, Siyi Cheng, Xiangxu Tao, Yan Zhong, Guanglan Liao, Zirong Tang
As a new class of pseudocapacitive material, metal sulfides possess high electrochemical performance. However, their cycling performance as conventional electrodes is rather poor for practical applications. In this article, we report an original composite electrode based on NiCo2S4@NiO core-shell nanowire arrays (NWAs) with enhanced cycling stability. This three-dimensional electrode also has a high specific capacitance of 12.2 F cm(-2) at the current density of 1 mA cm(-2) and excellent cycling stability (about 89% retention after 10,000 cycles)...
December 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27924295/dataset-on-the-physical-characterization-of-biopolymer-coated-magnetic-nanoparticles
#6
Shazia Bano, Muhammad Afzal
The data presented in this article is related to the research article entitled "Paclitaxel loaded magnetic nanocomposites with folate modified chitosan/carboxymethyl surface; a vehicle for imaging and targeted drug delivery" (S. Bano, M. Afzal, M.M. Waraich, K. Alamgir, S. Nazir, 2016) [1]. It contains the absorbance spectra, band gap energies of pure nickel-ferrite nano cores (NFs), and calibration curve of Paclitaxel. Thermal stability analysis of pure NFs, chitosan (CS) and carboxymethyl cellulose (CMC)-conjugated NFs samples is also included in the data...
December 2016: Data in Brief
https://www.readbyqxmd.com/read/27923907/deubiquitinase-usp13-maintains-glioblastoma-stem-cells-by-antagonizing-fbxl14-mediated-myc-ubiquitination
#7
Xiaoguang Fang, Wenchao Zhou, Qiulian Wu, Zhi Huang, Yu Shi, Kailin Yang, Cong Chen, Qi Xie, Stephen C Mack, Xiuxing Wang, Angel M Carcaboso, Andrew E Sloan, Gaoliang Ouyang, Roger E McLendon, Xiu-Wu Bian, Jeremy N Rich, Shideng Bao
Glioblastoma is the most lethal brain tumor and harbors glioma stem cells (GSCs) with potent tumorigenic capacity. The function of GSCs in tumor propagation is maintained by several core transcriptional regulators including c-Myc. c-Myc protein is tightly regulated by posttranslational modification. However, the posttranslational regulatory mechanisms for c-Myc in GSCs have not been defined. In this study, we demonstrate that the deubiquitinase USP13 stabilizes c-Myc by antagonizing FBXL14-mediated ubiquitination to maintain GSC self-renewal and tumorigenic potential...
December 6, 2016: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/27923764/applications-of-deep-eutectic-solvents-in-biotechnology-and-bioengineering-promises-and-challenges
#8
REVIEW
Yves Paul Mbous, Maan Hayyan, Adeeb Hayyan, Won Fen Wong, Mohd Ali Hashim, Chung Yeng Looi
Deep eutectic solvents (DESs) have been touted recently as potential alternatives to ionic liquids (ILs). Although they possess core characteristics that are similar to those of ILs (e.g., low volatility, non-flammability, low melting points, low vapor pressure, dipolar nature, chemical and thermal stability, high solubility, and tuneability), DESs are superior in terms of the availability of raw materials, the ease of storage and synthesis, and the low cost of their starting materials. As such, they have become the subject of intensive research in various sectors, notably the chemical, electrochemical, and biological sectors...
December 3, 2016: Biotechnology Advances
https://www.readbyqxmd.com/read/27923697/layer-by-layer-nanoparticle-platform-for-cancer-active-targeting
#9
Min Sung Suh, Jie Shen, Liisa T Kuhn, Diane J Burgess
Nanoparticles as drug delivery carriers have been investigated over the last few decades, particularly for cancer treatment. The rationale in developing such nanoparticles is to maximize drug efficacy while minimizing toxic side effects. This can be most effectively achieved through target specific drug delivery. A novel biocompatible nanoparticle platform prepared using the core-shell self-assembly technique is reported. The core consists of calcium phosphate which is biocompatible and pH-sensitive, and the shell is composed of biocompatible polymers (hyaluronic acid, CD44 targeting moiety; and chitosan, physical cross-linker)...
December 5, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27923696/correlating-gastric-emptying-of-amphotericin-b-and-paracetamol-solid-lipid-nanoparticles-with-changes-in-particle-surface-chemistry
#10
Hilda Amekyeh, Nashiru Billa, Clive Roberts
Oral delivery of pharmaceuticals requires that they retain their physical and chemical attributes during transit within the gastrointestinal (GI) tract, for the manifestation of desired therapeutic profiles. Solid lipid nanoparticles (SLNs) are used as carriers to improve the absorption of hydrophobic drugs. In this study, we examine the stability of amphotericin B (AmB) and paracetamol (PAR) SLNs in simulated GI fluids during gastric emptying. On contact with the simulated fluids, the particles increased in size due to ingress of the dissolution media into the particles...
December 5, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27923618/novel-3-methylindoline-inhibitors-of-ezh2-design-synthesis-and-sar
#11
Amantullah Ansari, Sharad Satalkar, Varshavekumar Patil, Amit S Shete, Simranjeet Kaur, Ashu Gupta, Siddhartha Singh, Mohd Raja, Daniel L Severance, Sebastián Bernales, Sarvajit Chakravarty, David T Hung, Son M Pham, Francisco J Herrera, Roopa Rai
EZH2 (enhancer of zeste homologue 2) is the catalytic subunit of the polycomb repressive complex 2 (PRC2) that catalyzes the methylation of lysine 27 of histone H3 (H3K27). Dysregulation of EZH2 activity is associated with several human cancers and therefore EZH2 inhibition has emerged as a promising therapeutic target. Several small molecule EZH2 inhibitors with different chemotypes have been reported in the literature, many of which use a bicyclic heteroaryl core. Herein, we report the design and synthesis of EZH2 inhibitors containing an indoline core...
November 25, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27922833/x-ray-photoelectron-spectroscopy-and-transmission-electron-microscopy-analysis-of-silver-coated-gold-nanorods-designed-for-bionanotechnology-applications
#12
Fumiya Watanabe, Zeid A Nima, Takumi Honda, Masatoshi Mitsuhara, Minoru Nishida, Alexandru S Biris
Multicomponent nano-agents were designed and built via a core-shell approach to enhance their surface enhanced Raman scattering (SERS) signals. These nano-agents had 36 nm × 12 nm gold nanorod cores coated by 4 nm thick silver shell films and a subsequent thin bifunctional thiolated polyethylene glycol (HS-PEG-COOH) layer. Ambient time-lapsed SERS signal measurements of these functionalized nanorods taken over a two-week period indicated no signal degradation, suggesting that large portions of the silver shells remained in pure metallic form...
December 6, 2016: Nanotechnology
https://www.readbyqxmd.com/read/27922204/encapsulation-of-bimetallic-metal-nanoparticles-into-robust-zr-based-metal-organic-frameworks-evaluation-of-the-catalytic-potential-for-size-selective-hydrogenation
#13
Christoph Rösler, Stefano Dissegna, Victor Lopez Rechac, Max Kauer, Penghu Guo, Stuart Turner, Kevin Ollegott, Hirokazu Kobayashi, Tomokazu Yamamoto, Daniel Peeters, Yuemin Wang, Syo Matsumura, Gustaaf Van Tendeloo, Hiroshi Kitagawa, Martin Muhler, Francesc X Llabrés I Xamena, Roland A Fischer
The realization of metal NPs with bimetallic character and distinct composition for specific catalytic applications is an intensively studied field. Due to the synergy between metals, most of the bimetallic particles exhibit unique properties, only hardly provided by the individual monometallic counterparts. However, as small sized NPs possess high surface energy, agglomeration during catalytic reactions is favored. Sufficient stabilization can be achieved by confinement of NPs in porous support materials. In this sense, especially MOFs gained a lot of attention during the last years, however, encapsulation of bimetallic species remains challenging...
December 6, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27921382/core-shell-silk-hydrogels-with-spatially-tuned-conformations-as-drug-delivery-system
#14
Le-Ping Yan, Joaquim M Oliveira, Ana L Oliveira, Rui L Reis
Hydrogels of spatially controlled physicochemical properties are appealing platforms for tissue engineering and drug delivery. In this study, core-shell silk fibroin (SF) hydrogels of spatially controlled conformation were developed. The core-shell structure in the hydrogels was formed by means of soaking the preformed (enzymatically crosslinked) random coil SF hydrogels in methanol. When increasing the methanol treatment time from 1 to 10 min, the thickness of the shell layer can be tuned from about 200 to about 850 μm as measured in wet status...
December 5, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27920900/polyelectrolyte-coating-on-superparamagnetic-iron-oxide-nanoparticles-as-interface-between-magnetic-core-and-biorelevant-media
#15
Etelka Tombácz, Katalin Farkas, Imre Földesi, Márta Szekeres, Erzsébet Illés, Ildikó Y Tóth, Daniel Nesztor, Tamás Szabó
Nanoparticles do not exist in thermodynamical equilibrium because of high surface free energy, thus they have only kinetic stability. Spontaneous changes can be delayed by designed surface coating. In biomedical applications, superparamagnetic iron oxide nanoparticles (SPIONs) require an optimized coating in order to fulfil the expectation of medicine regulatory agencies and ultimately that of biocompatibility. In this work, we show the high surface reactivity of naked SPIONs due to ≡Fe-OH sites, which can react with H(+)/OH(-) to form pH- and ionic strength-dependent charges...
December 6, 2016: Interface Focus
https://www.readbyqxmd.com/read/27918989/ph-responsive-polymeric-micelles-based-on-poly-ethyleneglycol-b-poly-2-diisopropylamino-ethyl-methacrylate-block-copolymer-for-enhanced-intracellular-release-of-anticancer-drugs
#16
Zhigang Xu, Peng Xue, Yong-E Gao, Shiying Liu, Xiaoxiao Shi, Meili Hou, Yuejun Kang
We present a pH-responsive poly(ethyleneglycol)-b-poly(2-(diisopropylamino) ethyl methacrylate) block copolymer (MPEG-PPDA) that can self-assemble into micelles at very low critical micelle concentration. The formed micelles exhibit superior stability in physiological environment and pH-triggered transforming capability between self-assembly and disassembly. Moreover, the resulting micelles can load hydrophobic anticancer drug molecules such as doxorubicin in the core of micelles. The pH-triggered drug release kinetics matches the classical hydrazone bond model...
November 27, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27918836/evolvix-best-names-for-semantic-reproducibility-across-code2brain-interfaces
#17
Laurence Loewe, Katherine S Scheuer, Seth A Keel, Vaibhav Vyas, Ben Liblit, Bret Hanlon, Michael C Ferris, John Yin, Inês Dutra, Anthony Pietsch, Christine G Javid, Cecilia L Moog, Jocelyn Meyer, Jerdon Dresel, Brian McLoone, Sonya Loberger, Arezoo Movaghar, Morgaine Gilchrist-Scott, Yazeed Sabri, Dave Sescleifer, Ivan Pereda-Zorrilla, Andrew Zietlow, Rodrigo Smith, Samantha Pietenpol, Jacob Goldfinger, Sarah L Atzen, Erika Freiberg, Noah P Waters, Claire Nusbaum, Erik Nolan, Alyssa Hotz, Richard M Kliman, Ayalew Mentewab, Nathan Fregien, Martha Loewe
Names in programming are vital for understanding the meaning of code and big data. We define code2brain (C2B) interfaces as maps in compilers and brains between meaning and naming syntax, which help to understand executable code. While working toward an Evolvix syntax for general-purpose programming that makes accurate modeling easy for biologists, we observed how names affect C2B quality. To protect learning and coding investments, C2B interfaces require long-term backward compatibility and semantic reproducibility (accurate reproduction of computational meaning from coder-brains to reader-brains by code alone)...
December 5, 2016: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/27917827/the-n14-anti-afamin-antibody-fab-a-rare-vl1-cdr-glycosylation-crystallographic-re-sequencing-molecular-plasticity-and-conservative-versus-enthusiastic-modelling
#18
Andreas Naschberger, Barbara G Fürnrohr, Tihana Lenac Rovis, Suzana Malic, Klaus Scheffzek, Hans Dieplinger, Bernhard Rupp
The monoclonal antibody N14 is used as a detection antibody in ELISA kits for the human glycoprotein afamin, a member of the albumin family, which has recently gained interest in the capture and stabilization of Wnt signalling proteins, and for its role in metabolic syndrome and papillary thyroid carcinoma. As a rare occurrence, the N14 Fab is N-glycosylated at Asn26L at the onset of the VL1 antigen-binding loop, with the α-1-6 core fucosylated complex glycan facing out of the L1 complementarity-determining region...
December 1, 2016: Acta Crystallographica. Section D, Structural Biology
https://www.readbyqxmd.com/read/27916697/composition-dependent-structural-changes-and-antitumor-activity-of-asc-dp-dspe-peg-nanoparticles
#19
Kenjirou Higashi, Fusako Mibu, Kengo Saito, Waree Limwikrant, Keiji Yamamoto, Kunikazu Moribe
Ascorbyl 2,6-dipalmitate (ASC-DP) and distearoyl phosphatidylethanolamine polyethylene glycol 2000 (DSPE-PEG) formed stable nanoparticles at a molar ratio of less than or equal to 2:1 after dispersing the solvent-evaporated film in water. The mean particle sizes measured by dynamic light scattering were within the range of ca. 100-160nm. Composition-dependent changes of the ASC-DP and DSPE-PEG molecular states within the film were analyzed by wide-angle X-ray diffraction and infrared (IR) and solid-state nuclear magnetic resonance (NMR) spectroscopy...
December 1, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27915290/localized-structural-frustration-for-evaluating-the-impact-of-sequence-variants
#20
Sushant Kumar, Declan Clarke, Mark Gerstein
Population-scale sequencing is increasingly uncovering large numbers of rare single-nucleotide variants (SNVs) in coding regions of the genome. The rarity of these variants makes it challenging to evaluate their deleteriousness with conventional phenotype-genotype associations. Protein structures provide a way of addressing this challenge. Previous efforts have focused on globally quantifying the impact of SNVs on protein stability. However, local perturbations may severely impact protein functionality without strongly disrupting global stability (e...
December 1, 2016: Nucleic Acids Research
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