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Core Stabilization

Alex Schudel, Lauren F Sestito, Susan N Thomas
Nitric oxide (NO) is a therapeutic implicated for the treatment of diseases affecting lymphatic tissues, which range from infectious and cardiovascular diseases to cancer. Existing technologies available for NO therapy, however, provide poor bioactivity within lymphatic tissues. In this work, we address this technology gap with a NO encapsulation and delivery strategy leveraging the formation of S-nitrosothiols on lymphatic-targeting Pluronic-stabilized, poly(propylene sulfide)-core nanoparticles (SNO-NP). We evaluated in vivo the lymphatic versus systemic delivery of NO resulting from intradermal administration of SNO-NP benchmarked against a commonly used, commercially available small molecule S-nitrosothiol NO donor, examined signs of toxicity systemically as well as localized to the site of injection, and investigated SNO effects on lymphatic transport and NP uptake by LN-resident cells...
January 20, 2018: Journal of Biomedical Materials Research. Part A
Hongwei Cheng, Xiaoshan Fan, Xiaoyuan Wang, Enyi Ye, Xian Jun Loh, Zibiao Li, Yun-Long Wu
In this report, a new star-like copolymer -CD-g-(PNIPAAm-b-POEGA)x consisting of a -CD core, grafted with temperature-responsive poly(N-isopropylacrylamide) (PNIPAAm) and biocompatible poly(oligo(ethylene glycol) acrylate) (POEGA) in a block copolymer of the arms, was used to deliver chemotherapeutics to drug resistant cancer tumours. The first step of the self-assembly process involves the encapsulation of chemotherapeutics through host-guest inclusion complexation between the -cyclodextrin cavity and the anti-cancer drug...
January 19, 2018: Biomacromolecules
Tanvir Ahmed, Javid Atai
The existence and stability of quiescent Bragg grating solitons are systematically investigated in a dual-core fiber, where one of the cores is uniform and has Kerr nonlinearity while the other one is linear and incorporates a Bragg grating with dispersive reflectivity. Three spectral gaps are identified in the system, in which both lower and upper band gaps overlap with one branch of the continuous spectrum; therefore, these are not genuine band gaps. However, the central band gap is a genuine band gap. Soliton solutions are found in the lower and upper gaps only...
September 2017: Physical Review. E
Kathrin S Bieri, Kelly Goodwin, Emin Aghayev, Hans-Joachim Riesner, Ralph Greiner-Perth
PURPOSE:  The primary aim of dynamic stabilization is to stabilize the spine and preserve function without overstressing adjacent segments, which is a potential risk of fusion surgery. However, direct comparative analyses of the two approaches are still limited, and little is known about the association of patient-reported outcomes with these treatment options. OBJECTIVE:  To compare the clinical outcomes of dynamic posterior stabilization using the DSS Stabilization System (Paradigm Spine, LLC, New York, New York, United States) versus posterior lumbar intervertebral fusion (PLIF) based on data from a spine registry...
January 18, 2018: Journal of Neurological Surgery. Part A, Central European Neurosurgery
Kunzhen Li, Shikuo Li, Fangzhi Huang, Xin-Yao Yu, Yan Lu, Lei Wang, Hong Chen, Hui Zhang
The hierarchical porous structure with phosphorus-doped Ni(OH)2 (P-Ni(OH)2) rods as the core and MnO2 nanosheets as the shell is fabricated directly by growth on a three-dimensional (3D) flexible Ni foam (NF) via a two-step hydrothermal process. As a binder-free electrode material, this unique hybrid structure exhibits excellent electrochemical properties, including an ultrahigh areal capacitance of 5.75 F cm-2 at a current density of 2 mA cm-2 and great cyclic stability without capacitance loss at a current density of 20 mA cm-2 after 10 000 cycles...
January 18, 2018: Nanoscale
Min Wu, Juan Li, Ruqin Zhang, Xia Tian, Zhaoxiang Han, Xiaoqing Lu, Kunpeng Guo, Zhike Liu, Zhongqiang Wang
Two spiroannulated molecular structures with dithiafulvenyl units functionalized at the 2,2',7,7'- (SFX-DTF1) and 2,3',6,'7- (SFX-DTF2) positions of a spiro[fluorene-9,9'-xanthene] core were synthesized. Studies revealed the hole mobility was significantly influenced by the dithiafulvenyl functionalized positions in the molecular structure. To explore their primary applications as hole-transporting materials in perovskite solar cells, SFX-DTF1-based devices exhibited a power conversion efficiency of 10.67% without the use of p-type dopants, yielding good air stability...
January 18, 2018: Organic Letters
V Shiltsev, Y Alexahin, A Burov, A Valishev
Modern and future particle accelerators employ increasingly higher intensity and brighter beams of charged particles and become operationally limited by coherent beam instabilities. Usual methods to control the instabilities, such as octupole magnets, beam feedback dampers, and use of chromatic effects, become less effective and insufficient. We show that, in contrast, Lorentz forces of a low-energy, magnetically stabilized electron beam, or "electron lens," easily introduce transverse nonlinear focusing sufficient for Landau damping of transverse beam instabilities in accelerators...
September 29, 2017: Physical Review Letters
Yuan Pan, Kaian Sun, Shoujie Liu, Xing Cao, Konglin Wu, Weng-Chon Cheong, Zheng Chen, Yu Wang, Yang Li, Yunqi Liu, Dingsheng Wang, Qing Peng, Chen Chen, Yadong Li
The construction of highly active and stable non-noble metal electrocatalysts for hydrogen and oxygen evolution reactions electrocatalysts is a major challenge for overall water splitting. Herein, we report a novel hybrid nanostructure with CoP na-noparticles (NPs) embedded in N-doped carbon nanotube hollow polyhedron (NCNHP) through a pyrolysis-oxidation-phosphidation strategy derived from core-shell ZIF-8@ZIF-67. Benefiting from the synergistic effects between highly active CoP NPs and NCNHP, the CoP/NCNHP hybrid exhibited outstanding bifunctional electrocatalytic performances...
January 17, 2018: Journal of the American Chemical Society
I V Zelepukin, V O Shipunova, A B Mirkasymov, P I Nikitin, M P Nikitin, S M Deyev
The creation of markers that provide both visual and quantitative information is of considerable importance for the mapping of tissue macrophages and other cells. We synthesized magnetic and magneto-fluorescent nanomarkers for the labeling of cells which can be detected with high sensitivity by the magnetic particle quantification (MPQ) technique. For stabilization under physiological conditions, the markers were coated with a dense silica shell. In this case, the size and zeta-potential of nanoparticles were controlled by a modified Stober reaction...
October 2017: Acta Naturae
Mst Ara Gulshan, Md Motiar Rahman, Shigeyoshi Matsumura, Tsunehiko Higuchi, Naoki Umezawa, Yoshiya Ikawa
Group I intron ribozymes share common core elements that form a three-dimensional structure responsible for their catalytic activity. This core structure is unstable without assistance from additional factors that stabilize its tertiary structure. We examined biogenic triamine and tetraamine and also their fragments for their abilities to stabilize a structurally unstable group I ribozyme, ΔP5 ribozyme, derived from the Tetrahymena group I intron ribozyme by deleting its large activator module. Biogenic triamine (spermidine) and tetraamine (spermine) efficiently activated the ΔP5 ribozyme under conditions where the ribozyme was virtually inactive...
January 12, 2018: Biochemical and Biophysical Research Communications
Carlos Eduardo Castro, Caroline Arana da Silva Ribeiro, Alex C Alavarse, Lindomar J C Albuquerque, Maria Cristina Carlan da Silva, Eliézer Jager, František Surman, Vanessa Schmidt, Cristiano Giacomelli, Fernando Carlos Giacomelli
The development of nanovehicles for intracellular drug delivery is strongly bound to the understating and control of nanoparticles cellular uptake process, which in turn is governed by surface chemistry. In this study, we explored the synthesis, characterization and cellular uptake of block copolymer assemblies consisting of a pH-responsive poly[2-(diisopropylamino)ethyl methacrylate] (PDPA) core stabilized by three different biocompatible hydrophilic shells (a zwitterionic type poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) layer, a highly hydrated poly(ethylene oxide) (PEO) layer with stealth effect, and an also proven non-toxic and non-immunogenic poly(N-(2-hydroxypropyl)methacrylamide) (PHPMA) layer)...
January 16, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Selma S Alkafeef, Clinton Yu, Lan Huang, Haoping Liu
The pathogenic fungus Candida albicans can undergo phenotypic switching between two heritable states: white and opaque. This phenotypic plasticity facilitates its colonization in distinct host niches. The master regulator WOR1 is exclusively expressed in opaque phase cells. Positive feedback regulation by Wor1 on the WOR1 promoter is essential for opaque formation, however the underlying mechanism of how Wor1 functions is not clear. Here, we use tandem affinity purification coupled with mass spectrometry to identify Wor1-interacting proteins...
January 16, 2018: PLoS Genetics
Roberto Quaranta, Jakob Fell, Frank Rühle, Jyoti Rao, Ilaria Piccini, Marcos J Araúzo-Bravo, Arie O Verkerk, Monika Stoll, Boris Greber
The transcription factor ISL1 is thought to be key for conveying the multipotent and proliferative properties of cardiac precursor cells. Here, we investigate its function upon cardiac induction of human embryonic stem cells. We find that ISL1 does not stabilize the transient cardiac precursor cell state but rather serves to accelerate cardiomyocyte differentiation. Conversely, ISL1 depletion delays cardiac differentiation and respecifies nascent cardiomyocytes from a ventricular to an atrial identity. Mechanistic analyses integrate this unrecognized anti-atrial function of ISL1 with known and newly identified atrial inducers...
January 16, 2018: ELife
Charles W Mcmonnies
PURPOSE: To examine the factors which contribute to tear stability and the validity and reliability of methods used for assessing tear break up time which is a core part of an examination of tear stability in dry eye patients. METHODS: A review of publications which are relevant to tear stability and its assessment. RESULTS: Tear break up time may be more invasive than intended if difficulty avoiding blinking during assessment results in reflex tearing...
January 11, 2018: Journal of Optometry
Bassel Akache, Felicity C Stark, Umar Iqbal, Wangxue Chen, Yimei Jia, Lakshmi Krishnan, Michael J McCluskie
Archaeosomes are liposomes comprised of ether lipids derived from various archaea. Unlike conventional ester-linked liposomes, archaeosomes exhibit high pH and thermal stability. As adjuvants, archaeosomes can induce robust, long-lasting humoral and cell-mediated immune responses and enhance protection in murine models of infectious disease and cancer. Archaeosomes constituted with total polar lipids (TPL) of various archaea are relatively complex, comprising >10 different lipid compounds. Archaeosomes can be constituted with semi-synthetic glycerolipids built on ether-linked isoprenoid phytanyl cores with varied synthetic glycol- and amino-head groups...
January 16, 2018: Human Vaccines & Immunotherapeutics
Tran Duy Thanh, Nguyen Dinh Chuong, Hoa Van Hien, Nam Hoon Kim, Joong-Hee Lee
Development of robust, cost-effective, and efficient catalyst is extremely necessary for oxygen reduction reaction (ORR) in fuel cell applications. Herein, we reported a well-defined nanostructured catalyst of highly dispersed CuAg@Ag core-shell nanoparticles (NPs) encapsulated nitrogen-doped graphene nanosheets (CuAg@Ag/N-GNS) to exhibit superior catalytic activity towards the ORR in alkaline medium. The synergistic effects produced from the unique properties of CuAg@Ag core-shell NPs and N-GNS nanosheets made such a novel nanohybrid to display a comparable catalytic behaviour to commercial Pt/C product...
January 16, 2018: ACS Applied Materials & Interfaces
Zhi Yue, Jana Shen
Solution pH plays an important role in protein dynamics, stability, and folding; however, detailed mechanisms remain poorly understood. Here we use continuous constant pH molecular dynamics in explicit solvent with pH replica exchange to describe the pH profile of the folding cooperativity of a miniprotein BBL, which has drawn intense debate in the past. Our data reconciled the two opposing hypotheses (downhill vs. two-state) and uncovered a sparsely populated unfolding intermediate. As pH is lowered from 7 to 5, the folding barrier vanishes...
January 16, 2018: Physical Chemistry Chemical Physics: PCCP
Lei He, Zhenyu Meng, Dechen Xu, Fangwei Shao
G-quadruplexes (GQ) folded by the oncogenic G-rich sequences are the promising targets for developing anticancer therapeutic molecules. However, the current drug development mainly focused on non-covalent dynamic binders to stabilize GQ structures, while the covalent targeting from inorganic complexes via chelating principles, as a potent therapeutic strategy was surprisingly lack of exploration. Herein, a series of dinuclear platinum complexes, [(Pt(Dip)Cl)2(μ-diamine)](NO3)2 (Dip: 4,7-diphenyl-1,10-phenanthroline), were designed to contain two dual-functional Pt cores connected by an alkyl linkage...
January 15, 2018: Scientific Reports
Meng Wang, Zhijian Peng, Jingwen Qian, Hong Li, Zengying Zhao, Xiuli Fu
As an important member of two-dimensional transition metal dichalcogenides, MoSe2 has a wide range of photoelectrochemical properties. However, MoSe2 alone can not directly be used as photocatalyst for its poor performance owing to the strong recombination of photogenerated electron-hole pairs. Here, we propose a novel C fibers@MoSe2 nanoplates core-shell composite, which was prepared by a facile, one-step thermal evaporation method. The composite has a remarkable feature of numerous MoSe2 thin nanoplates grown in-situ, densely and even vertically on the surface of the C fibers...
January 10, 2018: Journal of Hazardous Materials
Huang Wen, Hua Li, Suisui He, Fengjuan Chen, Erli Ding, Sha Liu, Baodui Wang, Yong Peng
Although substantial efforts have been made toward the synthesis of noble metal-semiconductor heteronanostructures, direct in situ synthesis of two-dimensional (2D) core-shell semiconductor@noble metal heterostructured nanosheets remains largely unexplored. Herein, we report the synthesis of a novel 2D core-shell CuFeSe2@Au heterostructured nanosheet with an amorphous core and a crystalline shell based on the reversed growth of Au nanosheets on the CuFeSe2 frameworks under near-infrared (NIR) illumination. The nanosheet exhibits strong absorbance in the NIR region, and the valence band top of CuFeSe2@Au nanosheets is higher than the oxidation potential of O2/H2O...
January 15, 2018: Nanoscale
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