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https://www.readbyqxmd.com/read/29136551/efficient-and-relatively-safe-emulsification-microextraction-using-a-deep-eutectic-solvent-for-influential-enrichment-of-trace-main-anti-depressant-drugs-from-complicated-samples
#1
Ahmad Ghoochani Moghadam, Maryam Rajabi, Alireza Asghari
In this research work, an efficient, facile, prompt, and relatively safe enrichment procedure, named as air agitated-emulsification microextraction based on a low density-deep eutectic solvent (AA-EME-LD-DES), was applied for the first time to separate trace amounts of the drugs escitalopram, desipramine, and imipramine from complex sample solutions. This bio-degradable and cheap choline chloride-based extracting agent was readily prepared by the easy blending process at the ambient temperature, resulting in a eutectic liquid mixture with distinct features...
September 28, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29133948/increased-hippocampal-tail-volume-predicts-depression-status-and-remission-to-anti-depressant-medications-in-major-depression
#2
J J Maller, K Broadhouse, A J Rush, E Gordon, S Koslow, S M Grieve
Studies of patients with major depressive disorder (MDD) have consistently reported reduced hippocampal volumes; however, the exact pattern of these volume changes in specific anatomical subfields and their functional significance is unclear. We sought to clarify the relationship between hippocampal tail volumes and (i) a diagnosis of MDD, and (ii) clinical remission to anti-depressant medications (ADMs). Outpatients with nonpsychotic MDD (n=202) based on DSM-IV criteria and a 17-item Hamilton Rating Scale for Depression (HRSD17) score ⩾16 underwent pretreatment magnetic resonance imaging as part of the international Study to Predict Optimized Treatment for Depression (iSPOT-D)...
November 14, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/29133056/therapeutic-potential-of-songorine-a-diterpenoid-alkaloid-of-the-genus-aconitum
#3
REVIEW
Haroon Khan, Seyed Mohammad Nabavi, Antoni Sureda, Nikolay Mehterov, Diana Gulei, Ioana Berindan-Neagoe, Hiroaki Taniguchi, Atanas G Atanasov
Alkaloids are well-studied secondary metabolites, with recent preclinical studies evidencing that many of them exhibit anti-cancer, anti-depressant, anti-nociceptive, anti-inflammatory, anti-pyretic, anti-platelet, anti-oxidant, and anti-bacterial properties. Aconitum is a genus rich of diverse alkaloids. More than 450 alkaloids have been identified in a variety of species. Songorine is a C20 diterpenoid alkaloid and 12-keto analog of napelline, isolated from Aconitum soongaricum and was associated with a heterogeneous panel of biological functions...
November 10, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29128343/post-stroke-depression-mechanisms-and-pharmacological-treatment
#4
REVIEW
Roberto Federico Villa, Federica Ferrari, Antonio Moretti
Depression, the most frequent psychiatric disorder following ischaemic stroke, negatively affects survivals' functional outcome, response to rehabilitation and quality of life. Approximately, one-third of them are affected by post-stroke depression (PSD), making it a serious social and public health problem and anti-depressant preventive and curative therapies worth investigating. However, a two-way association between depression and stroke has been also established: stroke increases the risk of PSD, but depression is an independent risk factor for stroke...
November 8, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29126988/morinda-officinalis-how-a-comprehensive-review-of-traditional-uses-phytochemistry-and-pharmacology
#5
REVIEW
Jian-Hua Zhang, Hai-Liang Xin, Yue-Ming Xu, Yi Shen, Yu-Qiong He, Hsien-Yeh, Bing Lin, Hong-Tao Song, Juan-Liu, Hai-Yue Yang, Lu-Ping Qin, Qiao-Yan Zhang, Juan Du
ETHNOPHARMACOLOGICAL RELEVANCE: The medicinal plant Morinda officinalisHow. (MO) and its root have long been used in traditional medicines in China and northeast Asia as tonics for nourishing the kidney, strengthening the bone and enhancing immunofunction in the treatment of impotence, osteoporosis, depression and inflammatory diseases such as rheumatoid arthritis and dermatitis. AIM OF THE REVIEW: This review aims to sum up updated and comprehensive information about traditional usage, phytochemistry, pharmacology and toxicology of MO and provide insights intopotential opportunities for future research and development of this plant...
November 7, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29126980/brain-derived-neurotrophic-factor-in-adjuvant-induced-arthritis-in-rats-relationship-with-inflammation-and-endothelial-dysfunction
#6
Martin Pedard, Céline Demougeot, Clément Prati, Christine Marie
OBJECTIVES: Both peripheral and central brain-derived neurotrophic factor (BDNF) levels are decreased in depression and normalized by efficient anti-depressive therapies. While depression symptoms are frequent in rheumatoid arthritis, BDNF has been poorly investigated in this pathology. Therefore, the present study explored cerebral and peripheral BDNF in arthritis rats as well as the link between brain BDNF and the two factors recently involved in the pathogenesis of depression and present in rheumatoid arthritis namely inflammation and endothelial dysfunction...
November 7, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29119301/whole-body-vibration-added-to-treatment-as-usual-is-effective-in-adolescents-with-depression-a-partly-randomized-three-armed-clinical-trial-in-inpatients
#7
Heidrun Lioba Wunram, Stefanie Hamacher, Martin Hellmich, Maxi Volk, Franziska Jänicke, Franziska Reinhard, Wilhelm Bloch, Philipp Zimmer, Christine Graf, Eckhard Schönau, Gerd Lehmkuhl, Stephan Bender, Oliver Fricke
There is growing evidence for the effectiveness of exercise in the treatment of adult major depression. With regard to adolescents, clinical trials are scarce. Due to the inherent symptoms of depression (lack of energy, low motivation to exercise), endurance training forms could be too demanding especially in the first weeks of treatment. We hypothesized that an easy-to-perform passive muscular training on a whole body vibration (WBV) device has equal anti-depressive effects compared to a cardiovascular training, both administered as add-ons to treatment as usual (TAU)...
November 8, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/29117851/estimating-individual-benefits-of-medical-or-behavioral-treatments-in-severely-ill-patients
#8
Francisco J Diaz
There is a need for statistical methods appropriate for the analysis of clinical trials from a personalized-medicine viewpoint as opposed to the common statistical practice that simply examines average treatment effects. This article proposes an approach to quantifying, reporting and analyzing individual benefits of medical or behavioral treatments to severely ill patients with chronic conditions, using data from clinical trials. The approach is a new development of a published framework for measuring the severity of a chronic disease and the benefits treatments provide to individuals, which utilizes regression models with random coefficients...
January 1, 2017: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/29109161/combating-multi-drug-resistant-pathogens-with-host-directed-non-antibiotic-therapeutics
#9
Jourdan A Andersson, Jian Sha, Michelle L Kirtley, Emily Reyes, Eric C Fitts, Sara M Dann, Ashok K Chopra
Earlier, we reported that 3 Food and Drug Administration-approved drugs, trifluoperazine (TFP, anti-psychotic), amoxapine (AXPN, anti-depressant), and doxapram (DXP, breathing stimulant), identified from an in vitro murine macrophage cytotoxicity screen, provided 40-60% protection to mice against pneumonic plague when administered at the time of infection for 1-3 days. In this study, the therapeutic potential of these drugs was further evaluated in mice when administered up to 48 h post-infection against pneumonic plague...
November 6, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29100860/development-of-new-quality-measures-for-hospital-based-care-of-suicidal-youth
#10
Layla Parast, Naomi S Bardach, Q Burkhart, Laura P Richardson, J Michael Murphy, Courtney A Gidengil, Maria T Britto, Marc N Elliott, Rita Mangione-Smith
OBJECTIVES: To develop, validate, and test the feasibility of implementation of four new quality measures assessing ED and inpatient care for suicidal youth. METHODS: Four quality measures were developed to assess hospital-based care for suicidal youth. These measures, focused on counseling caregivers about a) restricting access to lethal means of self-harm and b) benefits and risks of anti-depressant medications, were operationalized into 2 caregiver surveys, assessing ED and inpatient quality, respectively...
October 31, 2017: Academic Pediatrics
https://www.readbyqxmd.com/read/29099859/agomelatine-venlafaxine-and-running-exercise-effectively-prevent-anxiety-and-depression-like-behaviors-and-memory-impairment-in-restraint-stressed-rats
#11
Sarawut Lapmanee, Jantarima Charoenphandhu, Jarinthorn Teerapornpuntakit, Nateetip Krishnamra, Narattaphol Charoenphandhu
Several severe stressful situations, e.g., natural disaster, infectious disease out break, and mass casualty, are known to cause anxiety, depression and cognitive impairment, and preventive intervention for these stress complications is worth exploring. We have previously reported that the serotonin-norepinephrine-dopamine reuptake inhibitor, venlafaxine, as well as voluntary wheel running are effective in the treatment of anxiety- and depression-like behaviors in stressed rats. But whether they are able to prevent deleterious consequences of restraint stress in rats, such as anxiety/depression-like behaviors and memory impairment that occur afterward, was not known...
2017: PloS One
https://www.readbyqxmd.com/read/29096164/potential-factors-impacting-health-related-quality-of-life-among-patients-with-epilepsy-results-from-the-united-arab-emirates
#12
Taoufik Alsaadi, Seada Kassie, Khadija El Hammasi, Tarek M Shahrour, Mustafa Shakra, Lamya Turkawi, Wassim Nasreddine, Mufeed Raoof
PURPOSE: to investigate potential factors impacting HRQOL among PWE at a medical facility in the UAE. METHODS: Depression, anxiety, and health-related quality of life were assessed in 160 adult patients with epilepsy from September 2014 to January 2015 at Sheikh Khalifa Medical City (SKMC). The World Health Organization Quality of Life abbreviated scale (WHOQOL-BREF), the Patient Health Questionnaire nine-item (PHQ-9) depression scale, and Generalized Anxiety Disorder seven-item (GAD-7) scale were administered...
October 28, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29076953/acetyl-l-carnitine-supplementation-and-the-treatment-for-depressive-symptoms-a-systematic-review-and-meta-analysis
#13
Nicola Veronese, Brendon Stubbs, Marco Solmi, Olesya Ajnakina, Andre F Carvalho, Stefania Maggi
OBJECTIVE: Deficiency of acetyl-L-carnitine (ALC) appears to play a role in the risk of developing depression, indicating dysregulation of fatty acids transport across the inner membrane of mitochondria. However, the data regarding ALC supplementation in humans are limited.. We thus conducted a systematic review and meta-analysis investigating the effect of ALC on depressive symptoms across randomized controlled trials (RCTs). METHODS: A literature search in major databases, without language restriction, was undertaken from inception until 30 December 2016...
October 25, 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/29073219/environmental-enrichment-accelerates-ocular-dominance-plasticity-in-mouse-visual-cortex-whereas-transfer-to-standard-cages-resulted-in-a-rapid-loss-of-increased-plasticity
#14
Evgenia Kalogeraki, Justyna Pielecka-Fortuna, Siegrid Löwel
In standard cage (SC) raised mice, experience-dependent ocular dominance (OD) plasticity in the primary visual cortex (V1) rapidly declines with age: in postnatal day 25-35 (critical period) mice, 4 days of monocular deprivation (MD) are sufficient to induce OD-shifts towards the open eye; thereafter, 7 days of MD are needed. Beyond postnatal day 110, even 14 days of MD failed to induce OD-plasticity in mouse V1. In contrast, mice raised in a so-called "enriched environment" (EE), exhibit lifelong OD-plasticity...
2017: PloS One
https://www.readbyqxmd.com/read/29070884/telmisartan-activates-ppar%C3%AE-to-improve-symptoms-of-unpredictable-chronic-mild-stress-induced-depression-in-mice
#15
Yingxiao Li, Kai-Chun Cheng, Keng-Fan Liu, Wen-Huang Peng, Juei-Tang Cheng, Ho-Shan Niu
Major depression is a common mental disorder that has been established to be associated with a decrease in serotonin and/or serotonin transporters in the brain. Peroxisome proliferator-activated receptor δ (PPARδ) has been introduced as a potential target for depression treatment. Telmisartan was recently shown to activate PPARδ expression; therefore, the effectiveness of telmisartan in treating depression was investigated. In unpredictable chronic mild stress (UCMS) model, treatment with telmisartan for five weeks notably decrease in the time spent in the central and the reduced frequency of grooming and rearing in open filed test (OFT) and the decreased sucrose consumption in sucrose preference test (SPT) compared with the paradigms...
October 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29057467/vortioxetine-exerts-antiinflammatory-and-immunomodulatory-effects-on-human-monocytes-macrophages
#16
Maria Talmon, Silvia Rossi, Anna Pastore, Carlo Ignazio Cattaneo, Sandra Brunelleschi, Luigia Grazia Fresu
BACKGROUND AND PURPOSE: A crosstalk between the immune system and depression has been postulated, with a key role played by monocytes/macrophages and cytokines. In this paper we examined whether vortioxetine, a multimodal anti-depressive drug, was endowed of antiinflammatory and anti-oxidative activity, leading to immunomodulatory effects on human monocytes and macrophages. EXPERIMENTAL APPROACHES: Human monocytes were isolated from buffy coats and used as such or differentiated into M1 and M2 macrophages...
October 22, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29031144/senegenin-exerts-anti-depression-effect-in-mice-induced-by-chronic-un-predictable-mild-stress-via-inhibition-of-nf-%C3%AE%C2%BAb-regulating-nlrp3-signal-pathway
#17
Hongwei Li, Shiyi Lin, Tingting Qin, Hongyan Li, Zhanqiang Ma, Shiping Ma
Depressive disorder is a kind of affective disturbance disease. Emerging evidence has suggested that inflammation may contribute to the pathologic process of depressive disorder. Senegenin (SEN), a major bioactive constituent in Polygala tenuifolia Willd, has much bioactivity including anti-inflammatory and neuroprotection effects. However, the mechanism of its anti-depressant effect in mice remains unknown. This study aimed to explore the anti-depressant effects of SEN on behavioral changes and inflammatory responses in mice induced by chronic un-predictable mild stress (CUMS)...
October 11, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29020098/treatment-with-high-dose-antidepressants-severely-exacerbates-the-pathological-outcome-of-experimental-escherichia-coli-infections-in-poultry
#18
Sofie Kromann, Egle Kudirkiene, Lili Li, Ida Thoefner, Elisabeth Daldorph, Jens Peter Christensen, Hecheng Meng, Rikke Heidemann Olsen
There is an urgent need for novel antibiotics as the current antibiotics are losing their value due to increased resistance among clinically important bacteria. Sertraline, an on-marked anti-depressive drug, has been shown to modify bacterial activity in vitro, including increasing the susceptibility of Escherichia coli to antibiotics. The aim of the present study was to investigate if the antimicrobial activity of sertraline could be documented under clinical settings, hereunder if sertraline could potentiate the effect of tetracycline in treatment of an experimentally induced ascending infection in poultry...
2017: PloS One
https://www.readbyqxmd.com/read/29017624/sociodemographic-inequalities-in-the-management-of-depression-in-adults-aged-55-and-over-an-analysis-of-english-primary-care-data
#19
K Walters, M Falcaro, N Freemantle, M King, Y Ben-Shlomo
BACKGROUND: We do not know how primary care treatment of depression varies by age across both psychotropic medication and psychological therapies. METHODS: Cohort study including 19 710 people aged 55+ with GP recorded depression diagnoses and 26 276 people with recorded depression symptoms during the period 2009-2013, from 373 General Practices in The Health Improvement Network (THIN) database in England. Main outcomes were initiation of treatment with anti-depressants, anxiolytics, hypnotics, anti-psychotic drugs, referrals to psychological therapies within 6 months of onset...
October 11, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28992673/reflux-hypersensitivity-a-new-functional-esophageal-disorder
#20
REVIEW
Takahisa Yamasaki, Ronnie Fass
Reflux hypersensitivity, recently introduced by Rome IV as a new functional esophageal disorder, is currently considered as the presence of typical heartburn symptoms in patients with normal upper endoscopy and esophageal biopsies, normal esophageal pH test and with evidence of a close correlation between patients' heartburn and reflux events. Reflux hypersensitivity is very common and together with functional heartburn accounts for more than 90% of the heartburn patients who failed treatment with proton pump inhibitor twice daily...
October 30, 2017: Journal of Neurogastroenterology and Motility
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