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https://www.readbyqxmd.com/read/28928667/thirty-five-day-fluoxetine-treatment-limits-sensory-motor-deficit-and-biochemical-disorders-in-a-rat-model-of-decompression-sickness
#1
Caroline Cosnard, Sébastien De Maistre, Jacques H Abraini, Laurent Chazalviel, Jean-Eric Blatteau, Jean-Jacques Risso, Nicolas Vallée
According to the OECD statistical base for 2014, anti-depressants will, on average, be distributed at a rate of 62 daily doses per 1,000 inhabitants for the 25 countries surveyed (Health at a glance: Europe 2014; OECD Health Statistics; World Health Organization and OECD Health Statistics, 2014). Divers must be concerned. On another hand, divers are potentially exposed to decompression sickness including coagulation inflammation and ischemia, which can result in neurological lesions or even death. The purpose of this study is to assess whether chronic treatment with anti-depressants may represent a contraindication to the practice of an at-risk activity, such as, scuba diving, or even presents a benefit by attenuating the severity of the symptoms...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28927515/personal-and-perceived-depression-stigma-among-arab-adolescents-associations-with-depression-severity-and-personal-characteristics
#2
Latefa Ali Dardas, Susan G Silva, Moria J Smoski, Devon Noonan, Leigh Ann Simmons
BACKGROUND: In Arab communities, the selection, utilization, and attitudes towards mental health services are substantially affected by existing mental illness stigma. However, little is known about how the stigma of depression manifests among Arab adolescents, which makes it difficult to design, implement, and disseminate effective anti-stigma interventions for this vulnerable population. Therefore, the purpose of this study was to determine levels of depression stigma among Arab adolescents...
October 2017: Archives of Psychiatric Nursing
https://www.readbyqxmd.com/read/28891367/effect-of-foeniculum-vulgare-fennel-on-symptoms-of-depression-and-anxiety-in-postmenopausal-women-a-double-blind-randomised-controlled-trial
#3
Masumeh Ghazanfarpour, Fatemeh Mohammadzadeh, Paymaneh Shokrollahi, Talat Khadivzadeh, Mona Najaf Najafi, Hamidreza Hajirezaee, Maliheh Afiat
The aim of this study was to evaluate the effect of Foeniculum vulgare (fennel) on anxiety and depression symptoms in postmenopausal women. This study was a double-blind, randomised, placebo-controlled trial, in which 60 eligible postmenopausal women were selected and then randomly assigned to fennel and placebo groups. Then, symptoms of anxiety and depression were measured using Hospital Anxiety and Depression Scale (HADS) and Zung's Self Rating Depression Scale (SDS). Following the intervention, the score of HADS (depression and anxiety subgroups) and SDS did not show any significant decrease in the sample under study...
September 11, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28875858/managing-neuropathic-pain-in-multiple-sclerosis-pharmacological-interventions
#4
Samuel S Duffy, Justin G Lees, Chamini J Perera, Gila Moalem-Taylor
BACKGROUND: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS). Of the plethora of motor and sensory disturbances experienced by sufferers, neuropathic pain is a highly prevalent and debilitating symptom, and at present remains extremely difficult to treat. Common forms of neuropathic pain seen in MS patients include central neuropathic pain, Lhermitte's phenomenon and trigeminal neuralgia, which are all speculated to arise from specific patterns of lesion formation...
September 6, 2017: Medicinal Chemistry
https://www.readbyqxmd.com/read/28875366/saikosaponin-d-relieves-unpredictable-chronic-mild-stress-induced-depressive-like-behavior-in-rats-involvement-of-hpa-axis-and-hippocampal-neurogenesis
#5
Hong-Yan Li, Ying-Hua Zhao, Min-Jie Zeng, Fang Fang, Min Li, Ting-Ting Qin, Lu-Yu Ye, Hong-Wei Li, Rong Qu, Shi-Ping Ma
RATIONALE: Saikosaponin D (SSD), a major bioactive component isolated from Radix Bupleuri, has been reported to exert neuroprotective properties. OBJECTIVES: The present study was designed to investigate the anti-depressant-like effects and the potential mechanisms of SSD. METHODS: Behavioural tests including sucrose preference test (SPT), open field test (OFT) and forced swim test (FST) were performed to study the antidepressant-like effects of SSD...
September 5, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28868126/repeated-systemic-administration-of-the-cinnamon-essential-oil-possesses-anti-anxiety-and-anti-depressant-activities-in-mice
#6
Reyhaneh Sohrabi, Nasim Pazgoohan, Hasan Rezaei Seresht, Bahareh Amin
OBJECTIVES: The present study aimed to evaluate the putative antidepressant and anti-anxiety effects of the cinnamon essential oil when administered acute (for 3 doses) and sub-acute (for 14 days) to mice. MATERIALS AND METHODS: In an acute experimental study, forced swim test (FST) was conducted to evaluate the antidepressant-like behavior of animals treated with the intraperitoneal (IP) essential oil of cinnamon in triple doses (0.5, 1, and 2 mg/kg). In a sub-acute study (14 days in 24-hr intervals) antidepressant-like effects of essential oil (0...
June 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28866407/removal-of-emerging-organic-contaminants-in-a-poplar-vegetation-filter
#7
V Martínez-Hernández, M Leal, R Meffe, A de Miguel, C Alonso-Alonso, I de Bustamante, J Lillo, I Martín, J J Salas
Vegetation filters (VFs), a type of land application system, are a robust technology based on natural treatment mechanisms for the removal of wastewater contaminants. Their capacity to attenuate emerging organic contaminants (EOCs) has not yet been evaluated. The present study reports the results of a 2-year EOC monitoring carried out using a poplar VF receiving wastewater primarily treated by an Imhoff tank. The compounds selected included analgesics, a β-adrenergic blocker, stimulants, an anticonvulsant, an anti-depressant, an anti-inflammatory, an antibiotic and analgesic and stimulant metabolites...
August 24, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28865495/repetitive-transcranial-magnetic-stimulation-rtms-for-treatment-resistant-major-depression-trmd-veteran-patients-study-protocol-for-a-randomized-controlled-trial
#8
Zhibao Mi, Kousick Biswas, J Kaci Fairchild, Anne Davis-Karim, Ciaran S Phibbs, Steven D Forman, Michael Thase, Gerald Georgette, Tamara Beale, David Pittman, Margaret Windy McNerney, Allyson Rosen, Grant D Huang, Mark George, Art Noda, Jerome A Yesavage
BACKGROUND: Evaluation of repetitive transcranial magnetic stimulation (rTMS) for treatment-resistant major depression (TRMD) in Veterans offers unique clinical trial challenges. Here we describe a randomized, double-blinded, intent-to-treat, two-arm, superiority parallel design, a multicenter study funded by the Cooperative Studies Program (CSP No. 556) of the US Department of Veterans Affairs. METHODS: We recruited medical providers with clinical expertise in treating TRMD at nine Veterans Affairs (VA) medical centers as the trial local investigators...
September 2, 2017: Trials
https://www.readbyqxmd.com/read/28865338/impact-of-restarting-home-neuropsychiatric-medications-on-sedation-outcomes-in-medical-intensive-care-unit-patients
#9
Mary K La, Melissa L Thompson Bastin, Jenee T Gisewhite, Carrie A Johnson, Alexander H Flannery
PURPOSE: This single-center, retrospective cohort study investigated the effects of timing of initiating home neuropsychiatric medications (NPMs) on sedation-related outcomes. MATERIALS AND METHODS: Subjects included adult medical intensive care unit (MICU) patients who had an NPM on their admission medication list; intubated before or on arrival to the intensive care unit (ICU); and were on benzodiazepine-based sedation. The intervention assessed was the timing of the initiation of home NPMs: early (≤5days) vs...
July 29, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28855946/evaluation-of-the-central-and-peripheral-effects-of-doxepin-on-carrageenan-induced-inflammatory-paw-edema-in-rat
#10
Mohsen Zabihi, Valiollah Hajhashemi, Mohsen Minaiyan, Ardeshir Talebi
The anti-inflammatory effects of anti-depressants have been demonstrated recently. Doxepin, a tricyclic antidepressant drug (TCA), has some special properties in comparison with the other members of its family. It has some H1, H2, alpha-1 adrenergic and muscarinic receptor blocking effects. It revealed also anti-nociceptive and relatively potent sedative effects. This study was aimed to evaluate its possible anti-inflammatory effect in a well-established animal model. Male Wistar rats weighing 200-250 g were used in carrageenan-induced inflammatory paw edema model...
August 2017: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28837263/magnetic-micro-solid-phase-extraction-based-on-magnetite-mcm-41-with-gc-ms-for-the-determination-of-anti-depressant-drugs-in-biological-fluids
#11
Sazlinda Kamaruzaman, Mohd Marsin Sanagi, Noorfatimah Yahaya, Wan Aini Wan Ibrahim, Salasiah Endud, Wan Nazihah Wan Ibrahim
A new facile magnetic micro-solid-phase extraction coupled to gas chromatography and mass spectrometry detection was developed for extraction and determination of selected anti-depressant drugs in biological fluids using magnetite-MCM-41 as adsorbent. The synthesized sorbent was characterized by several spectroscopic techniques. The maximum extraction efficiency for extraction of 500 μg/L anti-depressant drugs from aqueous solution was obtained with 15 mg of magnetite-MCM-41 at pH 12. The analyte was desorbed using 100 μL of acetonitrile prior to gas chromatography determination...
August 24, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28818747/antidepressant-like-activity-of-methyl-jasmonate-involves-modulation-of-monoaminergic-pathways-in-mice
#12
Solomon Umukoro, Adaeze Adebesin, Gladys Agu, Osarume Omorogbe, Stephen Babajide Asehinde
PURPOSE: The efficacy of current antidepressant drugs has been compromised by adverse effects, low remission and delay onset of action necessitating the search for alternative agents. Methyl jasmonate (MJ), a bioactive compound isolated from Jasminum grandiflorum has been shown to demonstrate antidepressant activity but its mechanism of action remains unknown. Thus, the role of monoaminergic systems in the antidepression-like activity of MJ was investigated in this study. MATERIALS AND METHODS: Mice were given i...
August 14, 2017: Advances in Medical Sciences
https://www.readbyqxmd.com/read/28815415/type-2-diabetes-with-comorbid-depression-in-relation-to-cognitive-impairment-an-opportunity-for-prevention
#13
David A Zhang, Vicky Lam, Vanessa Chu, Ming Li
Studies show poor glycemic control is associated with increased risk of dementia among patients with Type 2 diabetes, indicating potential for prevention of dementia with improved glycemia. Emerging evidence suggests that a relationship between short-term glycemic control and cognitive function exists in Type 2 diabetes. However, detailed mechanisms relating diabetic dementia are lacking, as other concurrent conditions, such as depression, may also increase the risk of dementia in Type 2 diabetes. We examined the effects of glycemic control and depression on cognitive function in 88 patients (mean age, 67 ± 4 years) whose A1c (glycosylated hemoglobin) levels, comorbid depression, mini-mental state examination (MMSE) scores were recorded at baseline...
August 16, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28810562/anti-depressant-like-effects-of-jieyu-chufan-capsules-in-a-mouse-model-of-unpredictable-chronic-mild-stress
#14
Hui Zhao, Bingyu Liang, Linjie Yu, Yun Xu
Jieyu chufan (JYCF) is a well-known Chinese traditional medicine used for depression; however, the molecular mechanism underlying its anti-depressant action has remained elusive. In the present study, the anti-depressant effects of JYCF and the potential mechanisms were investigated in a mouse model. Five groups of 12 C57BL/6 mice each were used in the study, including a normal control group (NC group), a model control group (MC group) and three groups, which received different doses of JYCF (1.25, 2.5 and 5 g/kg) orally for 21 days (JYCF groups)...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28803855/elucidating-the-functions-of-brain-gsk3%C3%AE-possible-synergy-with-gsk3%C3%AE-upregulation-and-reversal-by-antidepressant-treatment-in-a-mouse-model-of-depressive-like-behaviour
#15
Dmitrii Pavlov, Nataliia Markova, Lucien Bettendorff, Vladimir Chekhonin, Igor Pomytkin, Viktoria Lioudyno, Andrei Svistunov, Eugene Ponomarev, Klaus-Peter Lesch, Tatyana Strekalova
Glycogen synthase kinase 3 (GSK3) has been linked to the mechanisms of stress, mood regulation, and the effects of antidepressants. The functions of the GSK3β isoform have been extensively investigated, but little is known about the α-isoform, although they may functionally related. In a recently established modified swim test with a third delayed swim exposure, brain GSK3β mRNA expression positively correlated with floating behaviour on the third test. A two-week-long pretreatment regime with imipramine (7...
August 10, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28792172/concept-and-identification-of-soft-bipolarity-in-patients-presenting-with-depression-need-for-careful-screening-by-physicians
#16
Pooja Patnaik Kuppili, Priyanka Yadav, Raman Deep Pattanayak
The bipolar spectrum is a broader concept, which questions the strict dichotomous categorical division of erstwhile manic-depressive illness into two discrete categories viz. bipolar disorder and major depressive disorder, thereby overlooking a wide 'spectrum' of patients which lie 'in between' the two extremes. The presence of underlying bipolar 'spectrum' or 'soft bipolarity' often goes undetected in patients presenting with major depression. This sub-group of patients may not stabilize with indiscriminate use of anti-depressant drugs, and without proper management, it may be associated with continued non-responsive symptoms, increased suicidality and poorer prognosis...
July 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28792097/a-closer-lens-cancer-survivors-supportive-intervention-preferences-and-interventions-received
#17
Joanna J Arch, Rachel Vanderkruik, Alex Kirk, Alaina L Carr
BACKGROUND: Cancer survivor preferences for formal interventions designed to provide psychological support remain relatively unknown. To address this gap, we evaluated cancer survivors' preferences for psychological intervention, whom they preferred to recommend such intervention, and how their preferences compared with what they currently received. METHODS: U.S. cancer survivors (n = 345) who were at least 2 months post-treatment for diverse forms of cancer were recruited online to complete a survey study...
August 9, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28789578/accelerated-itbs-treatment-in-depressed-patients-differentially-modulates-reward-system-activity-based-on-anhedonia
#18
Romain Duprat, Guo-Rong Wu, Rudi De Raedt, Chris Baeken
OBJECTIVES: Accelerated intermittent theta-burst stimulation (aiTBS) anti-depressive working mechanisms are still unclear. Because aiTBS may work through modulating the reward system and the level of anhedonia may influence this modulation, we investigated the effect of aiTBS on reward responsiveness in high and low anhedonic MDD patients. METHODS: In this registered RCT (NCT01832805), 50 MDD patients were randomised to a sham-controlled cross-over aiTBS treatment protocol over the left dorsolateral prefrontal cortex (DLPFC)...
August 9, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28782622/banxia-houpu-decoction-restores-glucose-intolerance-in-cums-rats-through-improvement-of-insulin-signaling-and-suppression-of-nlrp3-inflammasome-activation-in-liver-and-brain
#19
Ke-Ke Jia, Yan-Jing Zheng, Yan-Xiu Zhang, Jia-Hui Liu, Rui-Qing Jiao, Ying Pan, Ling-Dong Kong
ETHNOPHARMACOLOGICAL RELEVANCE: Banxia-houpu decoction is a famous formula in traditional Chinese medicine (TCM) with the powerful anti-depressant activity. AIM OF THE STUDY: This study aimed to investigate the effect of Banxia-houpu decoction on glucose intolerance associated with anhedonia in chronic unpredictable mild stress (CUMS) rats, then to explore its underlying pharmacological mechanisms. MATERIALS AND METHODS: After 6-week CUMS procedure, male Wistar rats were given Banxia-houpu decoction (3...
August 4, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28777476/clinical-depression-as-an-unfavorable-prognostic-factor-following-kidney-transplantation-how-can-we-explain-it
#20
Jeffrey J Gaynor, Gaetano Ciancio
In this issue Lentine et al(1) provide a well thought-out analysis of the prognostic value of antidepressant medication use (as a surrogate measure of clinical depression) on post-transplant outcome. Specifically, they show that among 72,054 SRTR patients receiving a kidney transplant during 2008-2015, anti-depressant use (obtained from pharmaceutical fill records) within one year of transplant and during the first year post-transplant (12.6% and 18.0% of patients, respectively) correlated with a significantly higher death rate during the first and 2(nd) year post-transplant (P<...
August 4, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
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