Pei Feng, Peizhuo Pang, Zehang Sun, Zhongyu Xie, Tingting Chen, Shan Wang, Qian Cao, Rujia Mi, Chenying Zeng, Yixuan Lu, Wenhui Yu, Huiyong Shen, Yanfeng Wu
BACKGROUND: Mesenchymal stem cells (MSCs) are pluripotent stem cells capable of differentiating into osteocytes, adipocytes and chondrocytes. However, in osteoporosis, the balance of differentiation tipped toward adipogenesis and the key mechanism is controversial. Researches have shown that, as upstream regulatory elements of gene expression, enhancers involved in the expression of identity genes. In this study, we identified enhancers-mediated gene FOXO3 promoting MSC adipogenic differentiation by activating autophagy...
December 1, 2023: Biochimica et Biophysica Acta. Molecular Basis of Disease