Hsiang-Ching Huang, Yi-Hsien Hsieh, Chi-Hao Hsiao, Chia-Yen Lin, Shian-Shiang Wang, Kuo-Hao Ho, Lun-Ching Chang, Huei-Mei Huang, Shun-Fa Yang, Ming-Hsien Chien
Monoamine oxidase B (MAOB), a neurotransmitter-degrading enzyme, was reported to reveal conflicting roles in various cancers. However, the functional role of MAOB and impacts of its genetic variants on prostate cancer (PCa) is unknown. Herein, we genotyped four loci of MAOB single-nucleotide polymorphisms (SNPs), including rs1799836 (A/G), rs3027452 (G/A), rs6651806 (A/C) and rs6324 (G/A) in 702 PCa Taiwanese patients. We discovered that PCa patients carrying the MAOB rs6324 A-allele exhibited an increased risk of having a high initial prostate-specific antigen (iPSA) level (>10 ng/mL)...
April 2024: Journal of Cellular and Molecular Medicine