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https://www.readbyqxmd.com/read/29333914/hybrid-pet-mri-imaging-in-healthy-unsedated-newborn-infants-with-quantitative-rcbf-measurements-using-15o-water-pet
#1
Julie B Andersen, Ulrich Lindberg, Oline V Olesen, Didier Benoit, Claes N Ladefoged, Henrik Bw Larsson, Liselotte Højgaard, Gorm Greisen, Ian Law
In this study, a new hybrid PET/MRI method for quantitative regional cerebral blood flow (rCBF) measurements in healthy newborn infants was assessed and the low values of rCBF in white matter previously obtained by arterial spin labeling (ASL) were tested. Four healthy full-term newborn subjects were scanned in a PET/MRI scanner during natural sleep after median intravenous injection of 14 MBq 15O-water. Regional CBF was quantified using a one-tissue-compartment model employing an image-derived input function (IDIF) from the left ventricle...
January 1, 2018: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29328889/respiratory-phenotypes-for-preterm-infants-children-and-adults-bronchopulmonary-dysplasia-and-more
#2
Joseph M Collaco, Sharon A McGrath-Morrow
Ongoing advancements in neonatal care since the late 1980's have led to increased numbers of premature infants surviving well beyond the neonatal period. As a result of increased survival, many individuals born preterm manifest chronic respiratory symptoms throughout infancy, childhood and adult life. The archetypical respiratory disease of prematurity, bronchopulmonary dysplasia (BPD), is the second most common chronic pediatric respiratory disease after asthma. However, there are several commonly held misconceptions...
January 12, 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29325234/prospective-associations-between-infant-sleep-at-12-months-and-autism-spectrum-disorder-screening-scores-at-24-months-in-a-community-based-birth-cohort
#3
A K Danny Nguyen, Laura E Murphy, Mehmet Kocak, Frances A Tylavsky, Linda S Pagani
BACKGROUND: Sleep problems have been associated with autism spectrum disorder (ASD) symptoms and diagnosis. However, past research has studied the simultaneous association of sleep problems with precursor ASD symptoms. Using data from a birth cohort, we estimate prospective associations between infant sleep characteristics at 12 months and later ASD screening scores at 24 months. METHODS: We obtained data from children (N = 1,096) and their mothers as participants in the Conditions Affecting Neurocognitive Development and Learning in Early Childhood longitudinal birth cohort study...
January 2, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29325155/sleep-findings-in-brazilian-children-with-congenital-zika-syndrome
#4
Luciana Pinato, Erlane M Ribeiro, Rebeka F P Leite, Thayse F Lopes, André L S Pessoa, Leila M Guissoni Campos, Giovanna E Piffer, Ana L D M Souza, Célia M Giacheti
Study Objectives: Zika virus infection during pregnancy may result in congenital Zika syndrome (CZS), whose characteristics are being described. Methods: The present study aimed to investigate the sleep characteristics of 136 infants/toddlers (88 with CZS and 48 with typical development (TD), age and gender matched, 60% girls and 40% boys in both groups) using the Brief Infant Sleep Questionnaire. The ages of children in both groups ranged from 5 to 24 months (CZS 15...
January 6, 2018: Sleep
https://www.readbyqxmd.com/read/29324729/vital-signs-trends-and-disparities-in-infant-safe-sleep-practices-united-states-2009-2015
#5
Jennifer M Bombard, Katherine Kortsmit, Lee Warner, Carrie K Shapiro-Mendoza, Shanna Cox, Charlan D Kroelinger, Sharyn E Parks, Deborah L Dee, Denise V D'Angelo, Ruben A Smith, Kim Burley, Brian Morrow, Christine K Olson, Holly B Shulman, Leslie Harrison, Carri Cottengim, Wanda D Barfield
There have been dramatic improvements in reducing infant sleep-related deaths since the 1990s, when recommendations were introduced to place infants on their backs for sleep. However, there are still approximately 3,500 sleep-related deaths among infants each year in the United States, including those from sudden infant death syndrome, accidental suffocation and strangulation in bed, and unknown causes. Unsafe sleep practices, including placing infants in a nonsupine (on side or on stomach) sleep position, bed sharing, and using soft bedding in the sleep environment (e...
January 12, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29317179/-adaptation-and-study-of-the-measurement-properties-of-a-sleep-questionnaire-for-infants-and-pre-school-children
#6
Pia Cassanello, Ana Díez-Izquierdo, Nuria Gorina, Nuria Matilla-Santander, Jose M Martínez-Sanchez, Albert Balaguer
INTRODUCTION: Although sleep disturbances in infants and toddlers are common, there is no suitable validated tool in Spanish to evaluate sleep disorders. The Brief Infant Sleep Questionnaire (BISQ) is a well-established multidimensional questionnaire widely used internationally. OBJECTIVES: To adapt the BISQ questionnaire to Spanish and analyse its reliability and validity. To explore its feasibility, both in the clinical context, and in epidemiological research...
January 6, 2018: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/29313308/noise-pollution-and-impact-on-children-health
#7
REVIEW
Alok Gupta, Anant Gupta, Khushbu Jain, Sweta Gupta
With rapid urbanization and life style changes, loud noise is omnipresent and has become a part of life. Indoor and outdoor environmental noise pollution have been documented as a serious health hazard with increasing adverse effects on fetus, infants, children, adolescents and adults. Noise induced hearing loss and non-auditory adverse effects due to noise pollution, are being increasingly diagnosed in all age groups including the fetus. Outdated motorized vehicles, machinery, increasing traffic, congested residential areas, crowded educational institutions and workplaces, unregulated commercial and industrial noise have become a source of noise pollution with long-term disability...
January 9, 2018: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29304420/local-changes-in-computational-non-rapid-eye-movement-sleep-depth-in-infants
#8
Anna-Liisa Satomaa, Outi Saarenpää-Heikkilä, Eero Huupponen, Turkka Kirjavainen, Juhani Heinonen, Sari-Leena Himanen
OBJECTIVE: Deep NREM sleep and its hallmark EEG phenomenon slow wave activity (SWA) are under homeostatic control in adults. SWA is also locally regulated as it increases in the brain areas that have been used intensively. Moreover, in children, SWA is a marker of cortical maturation. In the present study the local properties of NREM sleep depth were evaluated using the quantitative mean frequency method. We aimed to study if age is related to NREM sleep depth in young infants. In addition, we studied if young infants have local differences in their NREM sleep...
October 16, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29301586/effectiveness-of-a-psycho-educational-intervention-to-prevent-postpartum-parental-distress-and-enhance-infant-well-being-study-protocol-of-a-randomized-controlled-trial
#9
Marjolein Missler, Roseriet Beijers, Jaap Denissen, Annemieke van Straten
BACKGROUND: The first months after birth can be challenging for parents, leading to parental distress and decreased well-being. Parents with high levels of distress are found to respond less adequately and sensitively to their infant, which in turn affects infant well-being and health. The goal of this study is to examine the effectiveness of a psycho-educational intervention to prevent postpartum parental distress and enhance the quality of caregiving and infant well-being. In contrast to other interventions, this intervention will be (1) offered already before birth, (2) offered to all parents-to-be, regardless of their risk of postpartum distress, and (3) include fathers...
January 4, 2018: Trials
https://www.readbyqxmd.com/read/29300197/effectiveness-of-sucrose-used-routinely-for-pain-relief-and-neonatal-clinical-risk-in-preterm-infants-a-nonrandomized-study
#10
Beatriz Oliveira Valeri, Cláudia Maria Gaspardo, Francisco Eulógio Martinez, Maria Beatriz Martins Linhares
BACKGROUND: Preterm infants (PI) requiring the Neonatal Intensive Care Unit (NICU) are exposed to early repetitive pain/distress. Little is known about how pain relief strategies interact with infants'clinical health status, such as severity of illness with pain responses. This study aimed to examine main and interactive effects of routine sucrose intervention and neonatal clinical risk (NCR) on biobehavioral pain reactivity-recovery in PI during painful blood collection procedures. METHODS: Very-low birthweight PI (n=104) were assigned to Low and High Clinical Risk Groups, according to the Clinical Risk Index for Babies...
January 3, 2018: Clinical Journal of Pain
https://www.readbyqxmd.com/read/29299793/bed-sharing-in-the-first-8-weeks-of-life-an-australian-study
#11
H M Cunningham, H Vally, L Bugeja
Background As the evidence continues to emerge about the relationship between sudden unexpected death in infancy (SUDI) and the way an infant sleeps, providing consistent and evidence-informed recommendations on how best to sleep infants is an ongoing challenge. A recent case series study in the state of Victoria, Australia, identified 45.8% of sleep-related infant deaths occurred whilst bed-sharing. This study prompted the need for further exploration of infant sleeping practices, including bed-sharing, in this population...
January 3, 2018: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/29299712/cardiovascular-autonomic-dysfunction-in-sudden-infant-death-syndrome
#12
REVIEW
Rosemary S C Horne
A failure of cardiorespiratory control mechanisms, together with an impaired arousal response from sleep, are believed to play an important role in the final event of sudden infant death syndrome (SIDS). The 'triple risk model' describes SIDS as an event that results from the intersection of three overlapping factors: (1) a vulnerable infant, (2) a critical developmental period in homeostatic control and (3) an exogenous stressor. In an attempt to understand how the triple risk hypothesis is related to infant cardiorespiratory physiology, many researchers have examined how the known risk and protective factors for SIDS alter infant cardiovascular control during sleep...
January 3, 2018: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/29286936/haddad-syndrome-novel-association-with-braf-mutation
#13
Suleiman Al Dakhoul
This is a report of a 36 week male infant who suffered abdominal distension and difficulty opening bowels within first few days of life and showed a pattern of hypoventilation and apnea associated with sleep. His diagnostic studies confirmed the diagnosis of congenital central hypoventilation syndrome CCHS (PHOX2B mutation) and Hirschsprung's disease and later found a further mutation of BRAF oncogene. This describes a novel association between these mutations and the shared qualities of tumorigenesis between BRAF and PHOX2B...
2017: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/29277462/a-randomized-controlled-trial-to-prevent-infant-overweight-in-a-high-risk-population
#14
Elizabeth Reifsnider, David P McCormick, Karen W Cullen, Michael Todd, Michael W Moramarco, Martina R Gallagher, Lucia Reyna
INTRODUCTION: Infants are at risk of overweight. Infant overweight predisposes child, adolescent, and adult to obesity. OBJECTIVES: We hypothesized that parent education, initiated prenatally, and provided in the home, would reduce the incidence of infant overweight at age 12 months. METHODS: Pregnant obese Latina women were recruited at WIC and randomized to intervention versus control. Intervention subjects received home visits by trained Spanish-fluent community health workers who provided counseling on infant growth, breastfeeding, nutrition, child development, sleep, physical activity, and safety...
December 22, 2017: Academic Pediatrics
https://www.readbyqxmd.com/read/29243157/why-is-a-prone-sleeping-position-dangerous-for-certain-infants
#15
Roger W Byard, Fiona Bright, Robert Vink
The prone (face down) sleeping position is known to be associated with a significantly increased risk of sudden and unexpected death in infancy (sudden infant death syndrome or SIDS), however, the reasons for this are unclear. Suggested mechanisms have involved suffocation from occlusion of the external airways by soft bedding/pillows or from flattening of the nose with backward displacement of the tongue, rebreathing of carbon dioxide, blunting of arousal responses with decreased cardiac responses to auditory stimulation, diaphragmatic splinting or fatigue, lowering of vasomotor tone with tachycardia, nasopharyngeal bacterial overgrowth, overheating, alteration of sleep patterns, compromise of cerebral blood flow and upper airway obstruction from distortion of nasal cartilages...
December 14, 2017: Forensic Science, Medicine, and Pathology
https://www.readbyqxmd.com/read/29241201/cot-death-history-of-an-iatrogenic-disaster
#16
Michael Obladen
Since antiquity, cot death has been explained as accidental suffocation, overlaying, or smothering. Parents were blamed for neglect or drunkenness. A cage called arcuccio was invented around 1570 to protect the sleeping infant. Up to the 19th century, accidents were registered as natural causes of death. From 1830, accidental suffocation became unacceptable for physicians and legislators, and "natural" explanations for the catastrophe were sought, with parents being consoled rather than blamed. Two assumed causes had serious consequences: thymus hyperplasia was irradiated, causing thyroid cancer, and the concept of central apnea was widely accepted, which led to home monitors and distracted from epidemiological evidence...
December 15, 2017: Neonatology
https://www.readbyqxmd.com/read/29230867/sleep-patterns-and-problems-in-infants-and-young-children-in-ireland
#17
S Hanafin
BACKGROUND: There is an increasing recognition that sleep is an important aspect of health and well-being, and this is particularly the case in infancy and early childhood where sleep behaviours and patterns can result in substantial problems. METHODS: This paper draws on Wave 1, 2, and 3 data from Growing Up in Ireland, the national longitudinal study of children in Ireland to provide an overview of sleep patterns in a population of children aged 9 months (n = 11,112), 3 years (n = 9,790), and 5 years (n = 8,996)...
December 12, 2017: Child: Care, Health and Development
https://www.readbyqxmd.com/read/29226192/qualitative-assessment-of-pregnant-women-s-perceptions-of-infant-sleep-boxes
#18
Carolyn R Ahlers-Schmidt, Christy Schunn, Michelle L Redmond, Sharla Smith, Molly Brown, Stephanie N Kuhlmann, Matthew Engel, Mary Benton
Although several states have implemented programs providing boxes for infant sleep, safe sleep experts express concern regarding the paucity of safety and efficacy research on boxes. The purpose of this study was to assess pregnant women's perceptions regarding use of baby sleep boxes. A convenience sample was recruited from a community prenatal education program. Twenty-eight women were administered a brief semistructured interview about their knowledge of baby sleep boxes, opinions about the boxes, and questions they would have...
2017: Global Pediatric Health
https://www.readbyqxmd.com/read/29224235/long-term-cardiovascular-re-programming-by-short-term-perinatal-exposure-to-nicotine-s-main-metabolite-cotinine
#19
Stefano Bastianini, Viviana Lo Martire, Alessandro Silvani, Giovanna Zoccoli, Chiara Berteotti, Hugo Lagercrantz, Anders Arner, Gary Cohen
AIM: Gather "proof-of-concept" evidence of the adverse developmental potential of cotinine (a seemingly benign biomarker of recent nicotine / tobacco smoke exposure). METHODS: Pregnant C57 mice drank nicotine or cotinine-laced water for 6wks from conception (NPRE = 2% saccharin+100μg nicotine/ml; CPRE = 2% saccharin + 10μg cotinine/ml) or 3wks after birth (CPOST = 2% saccharin + 30μg cotinine/ml). Controls drank 2% saccharin (CTRL). At 17±1weeks (male pups; CTRL n=6; CPOST n=6; CPRE n=8; NPRE n=9) we assessed (i) cardiovascular control during sleep; (ii) arterial reactivity ex vivo; (iii) expression of genes involved in arterial constriction / dilation...
December 9, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/29221913/facial-asymmetry-correction-with-moulded-helmet-therapy-in-infants-with-deformational-skull-base-plagiocephaly
#20
Matthias Kreutz, Brigitte Fitze, Christoph Blecher, Augello Marcello, Ruben Simon, Rebecca Cremer, Hans-Florian Zeilhofer, Christoph Kunz, Johannes Mayr
PURPOSE: The recommendation issued by the American Academy of Pediatrics in the early 1990s to position infants on their back during sleep to prevent sudden infant death syndrome (SIDS) has dramatically reduced the number of deaths due to SIDS but has also markedly increased the prevalence of positional skull deformation in infants. Deformation of the base of the skull occurs predominantly in very severe deformational plagiocephaly and is accompanied by facial asymmetry, as well as an altered ear position, called ear shift...
October 16, 2017: Journal of Cranio-maxillo-facial Surgery
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