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https://www.readbyqxmd.com/read/28931039/abnormalities-in-substance-p-neurokinin-1-receptor-binding-in-key-brainstem-nuclei-in-sudden-infant-death-syndrome-related-to-prematurity-and-sex
#1
Fiona M Bright, Robert Vink, Roger W Byard, Jhodie R Duncan, Henry F Krous, David S Paterson
Sudden infant death syndrome (SIDS) involves failure of arousal to potentially life threatening events, including hypoxia, during sleep. While neuronal dysfunction and abnormalities in neurotransmitter systems within the medulla oblongata have been implicated, the specific pathways associated with autonomic and cardiorespiratory failure are unknown. The neuropeptide substance P (SP) and its tachykinin neurokinin-1 receptor (NK1R) have been shown to play an integral role in the modulation of homeostatic function in the medulla, including regulation of respiratory rhythm generation, integration of cardiovascular control, and modulation of the baroreceptor reflex and mediation of the chemoreceptor reflex in response to hypoxia...
2017: PloS One
https://www.readbyqxmd.com/read/28929527/music-exposure-and-maturation-of-late-preterm-sleep-wake-cycles-a-randomized-crossover-trial
#2
Adia Stokes, Alexander G Agthe, Dina El Metwally
AIM: To determine the effect of music on sleep-wake cycle (SWC) patterns in late preterm neonates. METHODS: In a masked crossover study, infants between 32-36 6/7 weeks gestation were randomized to music exposure either during the first six or last six hours of a 12-hour observation period. SWC characteristics were determined by continuous amplitude integrated electroencephalography (aEEG) read by two coders masked to exposure sequence. Analysis was done in paired comparisons...
September 20, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28922849/medullary-serotonin-neuron-abnormalities-in-an-australian-cohort-of-sudden-infant-death-syndrome
#3
Fiona M Bright, Roger W Byard, Robert Vink, David S Paterson
Serotonin (5-hydroxytryptamine [5-HT]) neurons in the medulla oblongata project extensively to key autonomic and respiratory nuclei in the brainstem and spinal cord regulating critical homeostatic functions. Multiple abnormalities in markers of 5-HT function in the medulla in sudden infant death syndrome (SIDS) have been reported, informing the hypothesis that at least a subset of SIDS cases is caused by deficits in 5-HT function resulting in impaired homeostatic responses to potentially life-threatening events during sleep...
October 1, 2017: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/28901633/response-to-mortazavi-s-comment
#4
Bellieni Carlo Valerio, Giuseppe Buonocore
Mortazavi's comment (1) on our letter (2) on whether electromagnetic fields (EMF) in incubators are a risk factor for autism contains several points that need to be corrected. First, we did not base our observations just on our previous papers as Mortazavi maintains. In fact, our observations were also based on several more papers about EMF in incubators, including the paper by Calvente et al, which was published in 2017 (3). Second, it is incorrect to write that a very simple intervention, such as changing the infants' sleep position, namely the position of the head and feet, can lead to a significant drop, as big as several orders of magnitude, in the infant's brain exposure (1), because in most incubators EMF levels are similar at all points of the mattress...
September 13, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28900155/inflexible-neurobiological-signatures-precede-atypical-development-in-infants-at-high-risk-for-autism
#5
Kristina Denisova, Guihu Zhao
Variability in neurobiological signatures is ubiquitous in early life but the link to adverse developmental milestones in humans is unknown. We examined how levels of signal and noise in movement signatures during the 1st year of life constrain early development in 71 healthy typically developing infants, either at High or Low familial Risk (HR or LR, respectively) for developing Autism Spectrum Disorders (ASD). Delays in early learning developmental trajectories in HR infants (validated in an analysis of 1,445 infants from representative infant-sibling studies) were predicted by worse stochastic patterns in their spontaneous head movements as early as 1-2 months after birth, relative to HR infants who showed more rapid developmental progress, as well as relative to all LR infants...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28899547/linear-dimensions-of-normal-upper-airway-structure-by-magnetic-resonance-imaging-in-chinese-han-infants-and-preschool-children
#6
Xiaoli Yi, Linyin Yao, Xinyu Yuan, Yongxiang Wei, Zhenchang Wang
OBJECTIVES: To establish normative data of upper airway structure in Chinese Han infants and preschool children. METHODS: Magnetic resonance imaging (MRI) scans of 521 Chinese Han infants and preschool children (225 girls, 296 boys) aged from 1 day to 72 months were selected from the children who underwent head MRI at the Capital Institute of Pediatrics Affiliated Children Hospital, Beijing, China. No subjects had sleep-disordered breathing or associated conditions that may have affected the upper airway anatomy...
September 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28899545/a-different-rhythm-of-life-sleep-patterns-in-the-first-4-years-of-life-and-associated-sociodemographic-characteristics-in-a-large-brazilian-birth-cohort
#7
Elena Netsi, Ina S Santos, Alan Stein, Fernando C Barros, Aluísio J D Barros, Alicia Matijasevich
OBJECTIVE: Sleep is an important marker of healthy development and has been associated with emotional, behavioral, and cognitive development. There is limited longitudinal data on children's sleep with only a few reports from low- and middle-income countries (LMICs). We investigate sleep parameters and associated sociodemographic characteristics in a population-based longitudinal study in Pelotas, Brazil. METHODS: Data from the Pelotas 2004 Birth Cohort were used (N = 3842)...
September 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28899531/sleep-disorders-and-allergic-diseases-in-chinese-toddlers
#8
Xu Wang, Xiang Gao, Qian Yang, Xia Wang, Shenghui Li, Fan Jiang, Jun Zhang, Fengxiu Ouyang
OBJECTIVE: Optimal sleep is important for child growth, development, and immune function. We aimed to explore whether sleep disorders were associated with the risk of allergic diseases in Chinese toddlers. METHODS: This study included 566 children (aged 23.9 ± 0.7 months; 51.1% boys) in Shanghai, China. Sleep parameters (total sleep time, sleep onset latency, nocturnal awaking and snoring) were assessed by an expanded version of the Brief Infant Sleep Questionnaire (BISQ-expanded)...
September 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28892546/insomnia-in-infants-and-young-children
#9
Judith A Owens, Maile Moore
Sleep problems in infants and young children are common and often underdiagnosed. The potential negative outcomes that chronic disrupted sleep can have on a child's daytime functioning, as well as the adverse impact it can have on the family, are well known. There is considerable evidence to support the use of behavioral interventions to treat childhood insomnia. These strategies not only produce reliable and durable positive changes in sleep in most young children, but may also improve child and family well-being without negative effects on a child's social-emotional development...
September 1, 2017: Pediatric Annals
https://www.readbyqxmd.com/read/28888494/stress-anxiety-depression-and-sleep-disturbance-among-jordanian-mothers-and-fathers-of-infants-admitted-to-neonatal-intensive-care-unit-a-preliminary-study
#10
Dua'a Fayiz Al Maghaireh, Khatijah Lim Abdullah, Mei Chan Chong, Yan Piaw Chua, Mariam Mefleh Al Kawafha
PURPOSE: To investigate the stressors and stress levels among Jordanian parents of infants in the NICU and their relationship to three factors: anxiety, depression and sleep disturbance. DESIGN AND METHODS: A cross-sectional survey was conducted in two hospitals in Jordan among 310 parents of infants in the NICU by using PSS: NICU and PROMIS. RESULTS: Both parents experienced high levels of stress, anxiety, depression and sleep disturbance...
September 2017: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/28885813/asleep-at-the-wheel-obstructive-sleep-apnea
#11
Richard J Fantus
Left untreated, OSA can lead to hypertension, stroke, congestive heart failure, and atrial fibrillation and s associated with type 2 diabetes and depression.... OSA strikes people of any age, including infants, and is most commonly seen in overweight or obese men older than 40 years of age.
June 2017: Bulletin of the American College of Surgeons
https://www.readbyqxmd.com/read/28881073/parental-professional-help-seeking-for-infant-sleep
#12
Pei-Wen Hsu, Wei-Wen Wu, Yi-Ching Tung, Karen A Thomas, Shao-Yu Tsai
AIMS: To explore the perceptions and experiences of parental professional help-seeking for infant sleep and sleep-related concerns. BACKGROUND: Infant sleep is a frequent concern for parents. However, very little is known about the reasons parents seek, do not seek, or delay seeking professional attention about their concerns related to infant sleep. DESIGN AND METHODS: A qualitative study design was used. Twenty audiotaped interviews with parents of healthy 12-month-old infants were conducted at a university-affiliated hospital or parents' homes depending on where parents felt more comfortable discussing their personal views and medical help-seeking experiences...
September 7, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28873072/amplitude-integrated-eeg-and-brain-sparing-in-preterm-small-for-gestational-age-infants
#13
Isabel Benavente-Fernández, Simón P Lubián-López, Pamela Zafra-Rodríguez, Almudena Alonso-Ojembarrena, Antonio Segado-Arenas, Alfonso M Lechuga-Sancho
PURPOSE: Preterm small-for-gestational-age (SGA) infants are at risk for a high mortality rate and impaired cognitive development. Only a few studies have focused on amplitude-integrated EEG (aEEG) in preterm SGA infants. They have been shown to have a slower rate of brain maturation, but these findings have not consistently been related to neurodevelopmental outcomes. The aim of our study was to evaluate early aEEG monitoring in SGA compared with adequate-for-gestational-age preterms...
September 2017: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
https://www.readbyqxmd.com/read/28869923/infant-maternal-and-familial-predictors-and-correlates-of-regulatory-problems-in-early-infancy-the-differential-role-of-infant-temperament-and-maternal-anxiety-and-depression
#14
Julia Martini, Johanna Petzoldt, Susanne Knappe, Susan Garthus-Niegel, Eva Asselmann, Hans-Ulrich Wittchen
BACKGROUND: Excessive infant crying, feeding and sleeping problems are likely to emerge from the complex interplay of various factors. AIMS: To investigate the role of infant (e.g., temperament), maternal (e.g., anxiety and depressive disorders), and familial (e.g., social support) factors as potential precursors of infant regulatory problems. STUDY DESIGN: Prospective-longitudinal study. SUBJECTS: 286 mother-infant dyads were investigated from early pregnancy until 16 months postpartum via questionnaires and interviews...
September 1, 2017: Early Human Development
https://www.readbyqxmd.com/read/28868896/stock-photographs-do-not-comply-with-infant-safe-sleep-guidelines
#15
Michael H Goodstein, Elena Lagon, Theodore Bell, Brandi L Joyner, Rachel Y Moon
We evaluated images in popular stock photography websites for adherence with American Academy of Pediatrics (AAP) guidelines for safe infant sleep practices. Three top stock photo websites were used to collect photographs generated from key phrases. All images depicting an infant sleep environment were analyzed for consistency with AAP guidelines. Descriptive statistics, chi-square and z test of proportions, were conducted. A total of 1233 of 1947 stock photographs showed sleeping infants on a flat surface...
September 1, 2017: Clinical Pediatrics
https://www.readbyqxmd.com/read/28866969/a-scoping-review-of-use-of-wearable-devices-to-evaluate-outcomes-in-survivors-of-critical-illness
#16
Samuel Gluck, Lee-Anne S Chapple, Marianne J Chapman, Theodore J Iwashyna, Adam M Deane
OBJECTIVE: Wearable devices using new technology may be a cost-effective method to assess functional outcomes in survivors of critical illness. Our primary objective was to review the extent to which wearable devices such as smartphones, pedometers, accelerometers and global positioning systems have been used to evaluate outcomes in survivors of an intensive care unit admission. DESIGN: We included studies of patients surviving an ICU admission and which measured outcomes using wearable devices...
September 2017: Critical Care and Resuscitation: Journal of the Australasian Academy of Critical Care Medicine
https://www.readbyqxmd.com/read/28860172/the-effect-of-inert-gas-choice-on-multiple-breath-washout-in-healthy-infants-differences-in-lung-function-outcomes-and-breathing-pattern
#17
Per Magnus Gustafsson, Lovisa Bengtsson, Anders Lindblad, Paul David Robinson
Detrimental effects on breathing pattern during multiple breath inert gas washout (MBW) have been described with different inhaled gases (100% oxygen, O2, and sulfur hexafluoride, SF6) but detailed comparisons are lacking. N2 and SF6 based tests were performed during spontaneous quiet sleep in 10 healthy infants aged 0.7-1.3 years using identical hardware. Differences in breathing pattern pre and post 100% O2 and 4% SF6 exposure were investigated, and the results obtained compared (FRC and Lung Clearance Index, LCI)...
August 31, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28856907/to-add-or-not-to-add-probiotics-to-infant-formulae-an-updated-systematic-review
#18
A Skórka, M Pieścik-Lech, M Kołodziej, H Szajewska
We updated evidence on the effects of the administration of probiotic-supplemented infant formulae (IF) compared with unsupplemented IF. Five databases were searched up to September 2016 for randomised controlled trials. Twenty publications were identified, including five new RCTs. Supplementation of IF with Bifidobacterium lactis Bb12, either alone or with Streptococcus thermophilus, had no effect on growth, respiratory illness, antibiotic use, stool frequency or consistency. However, there was a significant reduction in the number of episodes of gastrointestinal infections (Bb12) and a lower frequency of colic or irritability (when both strains were used)...
August 31, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/28852074/mapping-white-matter-microstructure-in-the-one-month-human-brain
#19
D C Dean, E M Planalp, W Wooten, N Adluru, S R Kecskemeti, C Frye, C K Schmidt, N L Schmidt, M A Styner, H H Goldsmith, R J Davidson, A L Alexander
White matter microstructure, essential for efficient and coordinated transmission of neural communications, undergoes pronounced development during the first years of life, while deviations to this neurodevelopmental trajectory likely result in alterations of brain connectivity relevant to behavior. Hence, systematic evaluation of white matter microstructure in the normative brain is critical for a neuroscientific approach to both typical and atypical early behavioral development. However, few studies have examined the infant brain in detail, particularly in infants under 3 months of age...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28842258/children-s-sleep-habits-questionnaire-infant-version
#20
Cláudia Alexandra Castro Dias, Bárbara Fernandes de Carvalho Figueiredo, Tiago Miguel Pires Pinto
OBJECTIVES: This study proposed a version of the Children's Sleep Habits Questionnaire for infants under 12 months (CSHQ-I). METHODS: The sample was comprised of 299 infants, aged between 2 weeks and 12 months. RESULTS: Exploratory factor analysis revealed four subscales: Bedtime Resistance, Sleep Anxiety, Positive Sleep Habits, and Daytime Sleepiness. The CSHQ-I total scale presented good test-retest reliability and internal consistency. The CSHQ-I also showed good concurrent validity, with significant associations found between the CSHQ-I total scale and subscales and a measure of infant sleep-wake behaviors...
August 22, 2017: Jornal de Pediatria
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