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https://www.readbyqxmd.com/read/28991025/the-costs-of-hiv-treatment-and-care-in-ghana
#1
Evelinn Mikkelsen, Jan A C Hontelez, Justice Nonvignon, Sam Amon, Felix A Asante, Moses K Aikins, Julie van de Haterd, Rob Baltussen
OBJECTIVE: To determine cost functions that describe the dynamics of costs of HIV treatment and care in Ghana by CD4 cell count at treatment initiation and over time on antiretroviral therapy (ART). DESIGN: We used detailed longitudinal healthcare utilization data from clinical health records of HIV-infected patients at seven Ghanaian ART clinics to estimate cost functions of treatment and care by CD4 cell count at treatment initiation and time on ART. METHODS: We developed two linear regression models; one with individual random effects to determine the relationship between CD4 cell count at ART initiation and costs of treatment and care, and one with individual fixed effects to determine the causal effect of time in care on costs of treatment and care...
October 23, 2017: AIDS
https://www.readbyqxmd.com/read/28985914/a-multinational-qualitative-investigation-of-the-perspectives-and-drivers-of-exercise-and-dietary-behaviors-in-people-living-with-hiv
#2
Allison R Webel, Joseph D Perazzo, Carol Dawson-Rose, Carolyn Smith, Patrice K Nicholas, Marta Rivero-Méndez, Solymar S Solís-Báez, Lucille Sanzero Eller, Mallory O Johnson, Inge B Corless, Teri Lindgren, William L Holzemer, Jeanne K Kemppainen, Paula Reid, Keitshokile Dintle Mogobe, Ella Matshediso, Kathleen Nokes, Carmen J Portillo
Globally, people living with HIV (PLWH) are at remarkably high risk for developing chronic comorbidities. While exercise and healthy eating reduce and mitigate chronic comorbidites, PLWH like many others, often fail to engage in recommended levels. We qualitatively examined the perspectives and contextual drivers of diet and exercise reported by PLWH and their health care providers. Two hundred and six participants across eight sites in the United States, Puerto Rico and Botswana described one overarching theme, Arranging Priorities, and four subthemes Defining Health, Perceived Importance of Diet and Exercise, Competing Needs, and Provider Influence...
October 2017: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/28979100/acceptability-of-community-based-adherence-clubs-among-health-facility-staff-in-south-africa-a-qualitative-study
#3
Ndumiso Tshuma, Ofentse Mosikare, Jessica A Yun, Olufunke A Alaba, Meera S Maheedhariah, Keith Muloongo, Peter S Nyasulu
BACKGROUND: Patient retention in care for HIV/AIDS is a critical challenge for antiretroviral treatment programs. Community-based adherence programs (CBAPs) as compared to health care facility-based adherence programs have been considered as one of the options to provide treatment maintenance support for groups of patients on antiretroviral therapy. Such an approach provides a way of enhancing self-management of the patient's condition. In addition, CBAPs have been implemented to support antiretroviral treatment expansion in resource-limited settings...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28975440/research-priorities-for-the-intersection-of-alcohol-and-hiv-aids-in-low-and-middle-income-countries-a-priority-setting-exercise
#4
Sara Gordon, Mary Jane Rotheram-Borus, Sarah Skeen, Charles Perry, Kendall Bryant, Mark Tomlinson
The harmful use of alcohol is a component cause for more than 200 diseases. The association between alcohol consumption, risk taking behavior and a range of infectious diseases such as HIV/AIDS is well established. The prevalence of HIV/AIDS as well as harmful alcohol use in low and middle income countries is high. Alcohol has been identified as a modifiable risk factor in the prevention and treatment of HIV/AIDS. The objective of this paper is to define research priorities for the interaction of alcohol and HIV/AIDS in low and middle income countries...
October 3, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28974351/accommodating-indigenous-nurse-initiated-and-managed-antiretroviral-therapy-nimart-reporting-in-a-developing-country-context
#5
Alistair M Brown
Financial reporting represents a critical tool in eliminating HIV across Papua New Guinea (PNG). Using the tenets of the theory of indigenous alternative reporting, this paper considers how the PNG Nursing Council may accommodate nurse-initiated and managed antiretroviral therapy (NIMART) reporting. Textual analysis of indigenous reporting expectations placed on the PNG Nursing Council are examined in a NIMART context to examine levels of reporting compliance exercised by council administrators from year-end reports (1980 to 2016) to accommodate NIMART reporting...
September 21, 2017: Journal of the Association of Nurses in AIDS Care: JANAC
https://www.readbyqxmd.com/read/28948451/a-diagnostic-approach-to-stroke-in-young-adults
#6
REVIEW
Christopher A Stack, John W Cole
Optimal diagnosis and management of stroke in young adults benefit from a multidisciplinary team, including a vascular neurology specialist. In addition to the "standard" vascular risk factors including smoking, hypertension, diabetes, and hyperlipidemia, one needs to consider alternative etiologies including substance abuse, carotid/vertebral artery dissections, and rare genetic conditions among others. Once a young patient is determined to have had a stroke, the next question a clinician should ask is why did this patient have a stroke? A "heart to head" diagnostic approach is recommended...
September 25, 2017: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28937582/design-of-the-exercise-mri-evaluation-of-hiv-pulmonary-arterial-hypertension-longitudinal-determinants-exhalted-trial
#7
Mohamad Amer Alaiti, Aditya Goud, Gautam Ramani, Sashwatee Bagchi, Sadeer Al-Kindi, Steven Sawicki, Christopher Longenecker, Trevor Jenkins, David Pauza, Myung Park, Grace McComsey, Orlando Simonetti, Brian Hoit, Sanjay Rajagopalan
BACKGROUND: Pulmonary arterial hypertension (PAH) is a potentially serious cause of dyspnea and exercise limitation in patients with HIV infection. In this trial, we propose using exercise MRI in conjunction with cardiopulmonary testing to delineate PAH from other causes of cardiovascular dysfunction, identify individuals with exercise-induced PAH who are at high risk of developing resting PAH, and provide longitudinal estimates of progression of PAH and right ventricular function. METHODS: In this prospective observational study, HIV patients with dyspnea and exercise limitation in the absence of identifiable causes and those who meet the inclusion criteria will be enrolled based on resting pulmonary artery pressure (≤ or >40 mmHg) on a screening echocardiogram and exercise limitation on the Modified Medical Research Council dyspnea scale...
September 20, 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/28935198/obesity-in-america
#8
Raul J Rosenthal, John Morton, Stacy Brethauer, Samer Mattar, Eric De Maria, Jennifer K Benz, Jennifer Titus, David Sterrett
BACKGROUND: The prevalence of obesity in America continues to grow significantly. Awareness and understanding of the disease of obesity and treatment options for it appear to be lacking among the general US population. OBJECTIVE: This study aimed to identify misperceptions in diagnosis and treatment of obesity, struggles Americans face in obtaining treatment, consequences of obesity, and perceived barriers to weight loss. SETTING: University hospital, United States...
August 12, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28911124/assessment-of-quality-of-antiretroviral-therapy-services-in-india-2014-2015
#9
Bharat Bhushan Rewari, Reshu Agarwal, Ramesh Reddy Allam, Nalini Chava, A S Rathore
Background: Following a decade of provision of free antiretroviral therapy (ART) in India, a nationwide assessment of ART services was conducted to review quality of care at ART centers. This paper presents the methods and defines replicable model of undertaking large scale assessments. Methods: During the period January 2014-March 2015, 357 ART centers were reviewed under four domains, namely, operations, technical, monitoring and evaluation (M&E), and logistics...
September 1, 2017: International Health
https://www.readbyqxmd.com/read/28900756/systematic-review-of-interventions-for-depression-for-people-living-with-hiv-in-africa
#10
REVIEW
Sarah M Lofgren, Noeline Nakasujja, David R Boulware
Depression interventions for individuals with HIV/AIDS in Africa are being increasingly evaluated. MEDLINE was searched using key terms: depression, Africa, and HIV, to identify depression interventions for HIV-infected adults in Africa. Perinatal women were excluded. Results were extracted and relative change in depression scores for interventions and net effect calculated. The MEDLINE search yielded 18 articles. Six of seven studies evaluating feasibility were positive, and seven of seven studies evaluating acceptability were also positive...
September 12, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28862527/agency-lapse-in-condom-use-and-relationship-intimacy-among-female-sex-workers-in-jamaica
#11
Althea E Bailey, John Peter Figueroa
This paper explores barriers to consistent condom use among female sex workers in Jamaica in a qualitative study using grounded theory. Multiple perspectives were sought through 44 in-depth interviews conducted with female sex workers, clients, the partners of sex workers and facilitators of sex work. Poverty and lack of education or skills, severely limited support systems as well as childhood abuse served to push the majority of participants into sex work and created vulnerability to HIV and other STIs. Despite these constraints, women found ways to exercise agency, ensure condom use, adopt protective measures and gain economic advantage in various aspects of the Jamaican sex trade...
September 1, 2017: Culture, Health & Sexuality
https://www.readbyqxmd.com/read/28837922/development-of-glut4-selective-antagonists-for-multiple-myeloma-therapy
#12
Changyong Wei, Richa Bajpai, Horrick Sharma, Monique Heitmeier, Atul D Jain, Shannon M Matulis, Ajay K Nooka, Rama K Mishra, Paul W Hruz, Gary E Schiltz, Mala Shanmugam
Cancer cells consume more glucose to fuel metabolic programs fundamental to sustaining their survival, growth and proliferation. Among the fourteen SLC2A family members, GLUTs 1 and 4 are high-affinity glucose transporters. GLUT4 (SLC2A4) is highly expressed in muscle and adipose tissue. Basally retained within the cell, GLUT4 traffics to the plasma membrane (PM) in response to insulin and exercise-stimulation. The plasma cell malignancy multiple myeloma (MM) exhibits increased constitutive expression of GLUT4 on the PM, co-opting use of GLUT4 for survival and proliferation...
October 20, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28837562/interventions-to-address-unequal-gender-and-power-relations-and-improve-self-efficacy-and-empowerment-for-sexual-and-reproductive-health-decision-making-for-women-living-with-hiv-a-systematic-review
#13
Jennifer L Robinson, Manjulaa Narasimhan, Avni Amin, Sophie Morse, Laura K Beres, Ping Teresa Yeh, Caitlin Elizabeth Kennedy
BACKGROUND: Many women living with HIV experience gendered power inequalities, particularly in their intimate relationships, that prevent them from achieving optimal sexual and reproductive health (SRH) and exercising their rights. We assessed the effectiveness of interventions to improve self-efficacy and empowerment of women living with HIV to make SRH decisions through a systematic review. METHODS AND FINDINGS: We included peer-reviewed articles indexed in PubMed, PsycINFO, CINAHL, Embase, and Scopus published through January 3, 2017, presenting multi-arm or pre-post intervention evaluations measuring one of the following outcomes: (1) self-efficacy, empowerment, or measures of SRH decision-making ability, (2) SRH behaviors (e...
2017: PloS One
https://www.readbyqxmd.com/read/28826230/optimism-alongside-new-challenges-using-a-rehabilitation-framework-to-explore-experiences-of-a-qualitative-longitudinal-cohort-of-people-living-with-hiv-on-antiretroviral-treatment-in-lusaka-zambia
#14
Stephanie A Nixon, Virginia Bond, Patricia Solomon, Cathy Cameron, Chanda Mwamba, Jill Hanass-Hancock, Margaret C Maimbolwa, J Anitha Menon, Phillimon Simwaba, Robert Sinyinza, Margaret Siwale, Stephen Tattle, Tammy Yates
Previous research has demonstrated increased comorbidities related to the chronic effects of HIV. Rehabilitation science offers a useful approach for studying chronic illness. This longitudinal qualitative study used a rehabilitation science approach to explore the experiences over time of women and men living with HIV and on antiretroviral therapy (ART) in the high HIV-prevalence setting of Lusaka, Zambia. Thirty-five participants participated in a total of 99 in-depth interviews from 2012 to 2015. The central pattern that emerged across the participants' narratives was the paradoxical experience of profound optimism alongside significant new challenges...
August 21, 2017: AIDS Care
https://www.readbyqxmd.com/read/28825859/evaluating-the-effectiveness-of-physical-exercise-interventions-in-persons-living-with-hiv-overview-of-systematic-reviews
#15
Emiko Kamitani, Theresa Ann Sipe, Darrel H Higa, Mary M Mullins, Jesus Soares
Physical exercise (PE) has not been well studied in persons living with HIV (PLHIV). We conducted an overview of systematic reviews to assess the effectiveness of PE and to determine the most appropriate PE regimen for PLHIV. We used the CDC's Prevention Research Synthesis Project's database and manual searches to identify systematic reviews published between 1996 and 2013. We qualitatively synthesized the findings from five reviews to assess the effectiveness of PE and conducted meta-analyses on CD4 counts to identify the best PE regimen...
August 2017: AIDS Education and Prevention: Official Publication of the International Society for AIDS Education
https://www.readbyqxmd.com/read/28806196/the-costs-of-hiv-treatment-and-care-in-ghana-a-longitudinal-multi-site-analysis
#16
Evelinn Mikkelsen, Jan Hontelez, Justice Nonvignon, Sam Amon, Felix A Asante, Moses K Aikins, Julie van de Haterd, Rob Baltussen
OBJECTIVE: To determine cost-functions that describe the dynamics of costs of HIV treatment and care in Ghana by CD4 cell count at treatment initiation and over time on antiretroviral therapy (ART). DESIGN: We used detailed longitudinal healthcare utilization data from clinical health records of HIV-infected patients at seven Ghanaian ART clinics to estimate cost-functions of treatment and care by CD4 cell count at treatment initiation and time on ART. METHODS: We developed two linear regression models; one with individual random effects to determine the relationship between CD4 cell count at ART initiation and costs of treatment and care, and one with individual fixed effects to determine the causal effect of time in care on costs of treatment and care...
August 12, 2017: AIDS
https://www.readbyqxmd.com/read/28802211/research-priority-setting-for-integrated-early-child-development-and-violence-prevention-ecd-in-low-and-middle-income-countries-an-expert-opinion-exercise
#17
Mark Tomlinson, Mark Jordans, Harriet MacMillan, Theresa Betancourt, Xanthe Hunt, Christopher Mikton
Child development in low and middle income countries (LMIC) is compromised by multiple risk factors. Reducing children's exposure to harmful events is essential for early childhood development (ECD). In particular, preventing violence against children - a highly prevalent risk factor that negatively affects optimal child development - should be an intervention priority. We used the Child Health and Nutrition Initiative (CHNRI) method for the setting of research priorities in integrated Early Childhood Development and violence prevention programs (ECD+)...
August 9, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28750615/implications-of-male-circumcision-for-women-in-papua-new-guinea-a-transformational-grounded-theory-study
#18
Michelle Redman-MacLaren, Jane Mills, Rachael Tommbe, David MacLaren, Rick Speare, William J H McBride
BACKGROUND: Male circumcision reduces the risk of female-to-male transmission of human immunodeficiency virus (HIV) and is being explored for HIV prevention in Papua New Guinea (PNG). PNG has a concentrated HIV epidemic which is largely heterosexually transmitted. There are a diverse range of male circumcision and penile modification practices across PNG. Exploring the implications of male circumcision for women in PNG is important to inform evidence-based health policy that will result in positive, intended consequences...
July 27, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/28750251/blood-borne-virus-testing-of-2250-patients-in-an-unusual-repeated-dental-patient-notification-exercise-challenges-faced-and-lessons-learnt
#19
H J Henderson, L Hopps, K M Roy
OBJECTIVES: The objectives of this study were to ascertain the risk created for patients of two dental practices where infection control was found to be inadequate, and if the risk was deemed to be significant, initiate an investigation involving notification and blood borne virus (BBV) testing to establish if any patient-to-patient BBV transmissions had occurred as a result of these infection control breaches. STUDY DESIGN: A case study. METHODS: A public health investigation and patient notification...
October 2017: Public Health
https://www.readbyqxmd.com/read/28746573/quality-of-life-socioeconomic-and-clinical-factors-and-physical-exercise-in-persons-living-with-hiv-aids
#20
Rafaela Catherine da Silva Cunha de Medeiros, Jason Azevedo de Medeiros, Tatiane Andreza Lima da Silva, Ricardo Dias de Andrade, Danielle Coutinho de Medeiros, Juliany de Souza Araújo, Antônio Manuel Gouveia de Oliveira, Marcos Aurélio de Albuquerque Costa, Paulo Moreira Silva Dantas
OBJECTIVE: To analyze whether socioeconomic and clinical aspects and the aspects of healthy life habits are associated with the quality of life of persons living with HIV/AIDS. METHODS: This is a cross-sectional exploratory quantitative research, with 227 persons living with HIV/AIDS, treated at two hospitals of reference between April 2012 and June 2014. We used structured questionnaires to assess socioeconomic aspects (gender, age, education level, marital status, race, socioeconomic status, dependents on family income, employment relationship), clinical parameters (time of disease diagnosis, use and time of medication, CD4 T-cell count, and viral load), and practice of physical exercise...
July 20, 2017: Revista de Saúde Pública
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