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https://www.readbyqxmd.com/read/29161262/the-value-of-confirmatory-testing-in-early-infant-hiv-diagnosis-programmes-in-south-africa-a-cost-effectiveness-analysis
#1
Lorna Dunning, Jordan A Francke, Divya Mallampati, Rachel L MacLean, Martina Penazzato, Taige Hou, Landon Myer, Elaine J Abrams, Rochelle P Walensky, Valériane Leroy, Kenneth A Freedberg, Andrea Ciaranello
BACKGROUND: The specificity of nucleic acid amplification tests (NAATs) used for early infant diagnosis (EID) of HIV infection is <100%, leading some HIV-uninfected infants to be incorrectly identified as HIV-infected. The World Health Organization recommends that infants undergo a second NAAT to confirm any positive test result, but implementation is limited. Our objective was to determine the impact and cost-effectiveness of confirmatory HIV testing for EID programmes in South Africa...
November 2017: PLoS Medicine
https://www.readbyqxmd.com/read/29161167/depression-and-marijuana-use-among-a-sample-of-urban-females-is-stage-of-development-important
#2
Leah Floyd Campbell
BACKGROUND: Increasing rates of marijuana use and high rates of depression among females are major public health concerns and ambiguous study results suggest a complex association between the two. Inconsistent findings may be due to differences in sample characteristics (e.g., females vs. males) and result from differences in the relationship over time (i.e., across developmental stages). OBJECTIVES: Presently, the extent to which the relationship between depression and marijuana use differed for females in emerging adulthood, compared to young adult females, was examined...
November 21, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/29161072/sexual-assertiveness-skills-and-sexual-decision-making-in-adolescent-girls-randomized-controlled-trial-of-an-online-program
#3
Laura Widman, Carol E Golin, Kristyn Kamke, Jeni L Burnette, Mitchell J Prinstein
OBJECTIVES: To evaluate the efficacy of an interactive, Web-based sexual health program (Health Education and Relationship Training [HEART]) for developing sexual assertiveness skills and enhancing sexual decision-making in adolescent girls. METHODS: Participants were 222 tenth-grade girls (mean age = 15.2; 38% White, 29% Hispanic, 25% Black) in the Southeastern United States who were randomized in fall 2015 to the HEART intervention or an attention-matched control...
November 21, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/29160949/failure-to-initiate-hiv-treatment-in-patients-with-high-cd4-counts-evidence-from-demographic-surveillance-in-rural-kwazulu-natal
#4
Jacob Bor, Calvin Chiu, Shahira Ahmed, Ingrid Katz, Matt Fox, Sydney Rosen, Manisha Yapa, Frank Tanser, Deenan Pillay, Till Bärnighausen
OBJECTIVES: To assess the relationship between CD4 count at presentation and ART uptake and assess predictors of timely treatment initiation in rural KwaZulu-Natal, South Africa. METHODS: We used Cox Proportional Hazards models to assess the association between first CD4 count and time from first CD4 to ART initiation amongst all treatment-naïve adults presenting to the Hlabisa HIV Treatment and Care Program between August 2011 and December 2012, with CD4<350 cells...
November 21, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29160948/disability-social-functioning-and-school-inclusion-among-older-children-and-adolescents-living-with-hiv-in-zimbabwe
#5
Ruramayi Rukuni, Grace McHugh, Edith Majonga, Katharina Kranzer, Hilda Mujuru, Shungu Munyati, Kusum Nathoo, Celia L Gregson, Hannah Kuper, Rashida A Ferrand
OBJECTIVE: Increasing numbers of children with HIV are surviving to adolescence and encountering multiple clinical and social consequences of longstanding HIV infection. We aimed to investigate the association between HIV and disability, social functioning and school inclusion among 6 to 16 year-olds in Zimbabwe. METHODS: HIV-infected children receiving antiretroviral therapy from a public sector HIV clinic, and HIV-uninfected children attending primary care clinics in the same catchment area were recruited...
November 21, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29160515/visceral-leishmaniasis-and-leishmaniasis-hiv-coinfection-comparative-study
#6
João Victor Soares Coriolano Coutinho, Fabiana Silva Dos Santos, Rosângela do Socorro Pereira Ribeiro, Iara Brito Bucar Oliveira, Victória Bezerra Dantas, Ana Barbara Feliciano Souza Santos, Jéssyca Rodrigues Tauhata
INTRODUCTION: This study aimed to draw clinical and epidemiological comparisons between visceral leishmaniasis (VL) and VL associated with human immunodeficiency virus (HIV) infection. METHOD: Retrospective study. RESULTS: Of 473 cases of VL, 5.5% were coinfected with HIV. The highest proportion of cases of both VL and VL/HIV were found among men. A higher proportion of VL cases was seen in children aged 0-10 years, whereas coinfection was more common in those aged 18-50 years...
September 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29160507/epidemiological-profile-of-patients-co-infected-with-visceral-leishmaniasis-and-hiv-aids-in-northeast-brazil
#7
Graça Maria de Castro Viana, Marcos Antonio Custódio Neto da Silva, João Victor de Sousa Garcia, Helaine Dias Guimarães, Gelson Farias Arcos, Augusto Viana Arouche Santos, Pedro Viana da Paixão, Maria do Desterro Soares Brandão Nascimento, Carolina de Souza Galvão
INTRODUCTION: Visceral leishmaniasis (VL) and human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) co-infection has been a research topic of interest worldwide. In Brazil, it has been observed that there is a relative underreporting and failure in the understanding and management of this important association. The aim of this study was to analyze epidemiological and clinical aspects of patients with VL with and without HIV/AIDS. METHODS: We conducted an observational and analytical study of patients with VL followed in a Reference Service in the State of Maranhão, Brazil from 2007-2013...
September 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29160506/treatment-adherence-in-patients-living-with-hiv-aids-assisted-at-a-specialized-facility-in-brazil
#8
Simone Miyada, Artênio José Ísper Garbin, Renata Colturato Joaquim Gatto, Cléa Adas Saliba Garbin
INTRODUCTION: In the 1990s, Brazil adopted a public policy that allowed for universal, free access to antiretroviral therapy (ART). Since then, treatment adherence has become a new challenge for administrators of sexually transmitted disease/acquired immunodeficiency syndrome (STD/AIDS) policies. This study quantified adherence to ART and verified whether there is an association between sociodemographic variables and clinical/laboratory data in human immunodeficiency virus (HIV)-infected patients...
September 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29160443/body-fat-redistribution-and-changes-in-lipid-and-glucose-metabolism-in-people-living-with-hiv-aids
#9
Rebeca Antunes Beraldo, André Pereira Dos Santos, Mariana Palma Guimarães, Helena Siqueira Vassimon, Francisco José Albuquerque de Paula, Dalmo Roberto Lopes Machado, Maria Cristina Foss-Freitas, Anderson Marliere Navarro
INTRODUCTION: The HIV lipodystrophy syndrome is characterized by changes in metabolism, and body composition that increase cardiovascular risk of people living with HIV/AIDS (PLWHA) using highly active antiretroviral therapy (HAART). OBJECTIVE: To assess the prevalence of lipodystrophy and changes in lipid and glucose metabolism in PLWHA in use of HAART. METHODS: For the anthropometric evaluation we measured weight, height and abdominal circumference (AC)...
July 2017: Revista Brasileira de Epidemiologia, Brazilian Journal of Epidemiology
https://www.readbyqxmd.com/read/29160433/individual-and-contextual-level-factors-associated-with-client-initiated-hiv-testing
#10
Claudia Renata Dos Santos Barros, Eliana Miura Zucchi, Lilia Blima Schraiber, Ivan França
BACKGROUND: Knowing the reasons for seeking HIV testing is central for HIV prevention. Despite the availability of free HIV counseling and testing in Brazil, coverage remains lacking. METHODS: Survey of 4,760 respondents from urban areas was analyzed. Individual-level variables included sociodemographic characteristics; sexual and reproductive health; HIV/AIDS treatment knowledge and beliefs; being personally acquainted with a person with HIV/AIDS; and holding discriminatory ideas about people living with HIV...
July 2017: Revista Brasileira de Epidemiologia, Brazilian Journal of Epidemiology
https://www.readbyqxmd.com/read/29159965/improvement-in-lipids-after-switch-to-boosted-atazanavir-or-darunavir-in-children-adolescents-with-perinatally-acquired-hiv-on-older-protease-inhibitors-results-from-the-pediatric-hiv-aids-cohort-study
#11
J Jao, W Yu, K Patel, T L Miller, B Karalius, M E Geffner, L A DiMeglio, A Mirza, J S Chen, M Silio, E J McFarland, R B Van Dyke, D Jacobson
OBJECTIVES: Dyslipidaemia is common in perinatally HIV-infected (PHIV) youth receiving protease inhibitors (PIs). Few studies have evaluated longitudinal lipid changes in PHIV youth after switch to newer PIs. METHODS: We compared longitudinal changes in fasting lipids [total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and TC:HDL-C ratio] in PHIV youth enrolled in the Pediatric HIV/AIDS Cohort Study (PHACS) Adolescent Master Protocol (AMP) study who switched to atazanavir/ritonavir (ATV/r)- or darunavir/ritonavir (DRV/r)-based antiretroviral therapy (ART) from an older PI-based ART and those remaining on an older PI...
November 21, 2017: HIV Medicine
https://www.readbyqxmd.com/read/29159595/resilience-and-physical-and-mental-well-being-in-adults-with-and-without-hiv
#12
Jennifer A McGowan, James Brown, Fiona C Lampe, Marc Lipman, Colette Smith, Alison Rodger
Resilience has been related to improved physical and mental health, and is thought to improve with age. No studies have explored the relationship between resilience, ageing with HIV, and well-being. A cross sectional observational study performed on UK HIV positive (N = 195) and HIV negative adults (N = 130). Associations of both age and 'time diagnosed with HIV' with resilience (RS-14) were assessed, and the association of resilience with depression, anxiety symptoms (PHQ-9 and GAD-7), and problems with activities of daily living (ADLs) (Euroqol 5D-3L)...
November 20, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/29159533/reduced-bone-mineral-density-in-human-immunodeficiency-virus-infected-individuals-a-meta-analysis-of-its-prevalence-and-risk-factors
#13
S S L Goh, P S M Lai, A T B Tan, S Ponnampalavanar
A meta-analysis was conducted to evaluate the prevalence of osteopenia/osteoporosis in human immunodeficiency virus (HIV)-infected individuals. The prevalence of osteopenia/osteoporosis in HIV-infected and antiretroviral therapy (ART)-treated individuals was significantly higher than respective controls. Evidence regarding bone loss within first year of HIV infection or ART initiation was preliminary. PURPOSE: The aim of the study is to systematically review published literature on the prevalence of osteopenia/osteoporosis and its associated risk factors in HIV-infected individuals...
November 20, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29158917/lipodystrophy-among-hiv-infected-patients-attending-care-and-treatment-clinics-in-dar-es-salaam
#14
Marina Njelekela, Rose Mpembeni, Alfa Muhihi, Nzovu Ulenga, Eric Aris, Deodatus Kakoko
Background: HIV infection and long-term HAART use are associated with metabolic and morphological changes. We assessed prevalence, types, and risk factors associated with lipodystrophy among HIV-infected adults attending CTC in Dar es Salaam, Tanzania. Methods: Analysis included 466 HIV-infected patients. Study protocol involved administration of structured questionnaire to collect sociodemographic and clinical information. Diagnosis of lipodystrophy was based on physician clinical assessment...
2017: AIDS Research and Treatment
https://www.readbyqxmd.com/read/29158864/-chronic-kidney-disease-associated-factors-etiologies-clinical-and-biological-parameters-at-lubumbashi-city-in-democratic-republic-of-congo
#15
Serge Muleka Ngoie, Philippe Mulenga, Olivier Mukuku, Christian Ngama Kakisingi, Cédrick Milindi Sangwa, Pascal Tshimwang Nawej, Claude Mulumba Mwamba, Dophra Nkulu Ngoy, Faustin Wa Pa Manda Muteta
Introduction: Chronic kidney disease is fast becoming a worldwide public health problem due to the increase of hypertension and diabetes mellitus, its main risk factors. In countries like DRC where majority of population are in the low income bracket, very few studies about this disease, usually diagnosed at a very advanced stage have been conducted. As a result of such, cases are not always properly taken care of and managed. Methods: We opted for a descriptive cross-sectional study and it was conducted during the period from July 2014 to July 2015 at CMDC dialysis service...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/29157301/family-support-discrimination-and-quality-of-life-among-art-treated-hiv-infected-patients-a-two-year-study-in-china
#16
Jun-Fang Xu, Zhong-Qiang Ming, Yu-Qian Zhang, Pei-Cheng Wang, Jun Jing, Feng Cheng
BACKGROUND: By September 2016, approximately 653,865 people in China were living with HIV/AIDS (PLWHA) and 492,725 people were receiving antiretroviral therapy (ART). PLWHA frequently experience discrimination in all domains of their personal and social lives. The World Health Organization includes discrimination in its list of social determinants of health factors that have been linked to poor physical and psychological health. This paper identifies the family support enjoyed and discrimination faced by people infected with HIV and examines the effect they have on patients' quality of life (QOL) as they undergo ART in China...
November 21, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/29157275/the-prevent-study-to-evaluate-the-effectiveness-and-acceptability-of-a-community-based-intervention-to-prevent-childhood-tuberculosis-in-lesotho-study-protocol-for-a-cluster-randomized-controlled-trial
#17
Yael Hirsch-Moverman, Andrea A Howard, Koen Frederix, Limakatso Lebelo, Anneke Hesseling, Sharon Nachman, Joanne E Mantell, Tsepang Lekhela, Llang Bridget Maama, Wafaa M El-Sadr
BACKGROUND: Effective, evidence-based interventions to prevent childhood tuberculosis (TB) in high TB/HIV-burden, resource-limited settings are urgently needed. There is limited implementation of evidence-based contact management strategies, including isoniazid preventive therapy (IPT), for child contacts of TB cases in Lesotho. METHODS/DESIGN: This mixed-methods implementation science study utilizes a two-arm cluster-randomized trial design with randomization at the health facility level...
November 21, 2017: Trials
https://www.readbyqxmd.com/read/29157230/barriers-and-facilitators-to-implementing-an-evidence-based-woman-focused-intervention-in-south-african-health-services
#18
Brittni N Howard, Richard Van Dorn, Bronwyn J Myers, William A Zule, Felicia A Browne, Tara Carney, Wendee M Wechsberg
BACKGROUND: Since the beginning of the HIV epidemic, numerous behavior change, risk-reduction, and biomedical interventions have been developed and tested. While some of these interventions have shown to be efficacious in randomized trials, it often takes almost two decades for an intervention to be translated into practice. Meanwhile, South Africa continues to have among the highest prevalence of HIV globally, with women of childbearing age bearing the burden of the epidemic. Given the urgency of the HIV epidemic among vulnerable women in South Africa, it is imperative that evidence-based interventions be implemented rapidly into practice...
November 21, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/29155891/the-burden-of-gynecomastia-among-men-on-antiretroviral-therapy-in-zomba-malawi
#19
Victor Singano, Alemayehu Amberbir, Daniela Garone, Christopher Kandionamaso, Jack Msonko, Monique van Lettow, Kondwani Kalima, Yamikani Mataka, Gift Kawalazira, Gabriel Mateyu, Aunex Kwekwesa, Alfred Matengeni, Joep J van Oosterhout
BACKGROUND: Many Africans who are on life-saving ART face challenges from a variety of toxicities. After the introduction of a standardized first-line efavirenz-containing ART regimen, reports of gynecomastia appeared in Malawian popular media, however data on the prevalence and risk factors of gynecomastia from Africa are lacking. METHODS: We conducted a cross-sectional study in males ≥18 years registered on ART at the HIV clinic in Zomba Central Hospital. Men who reported to have ever experienced breast or nipple enlargement received a standard questionnaire and underwent physical examination...
2017: PloS One
https://www.readbyqxmd.com/read/29155877/immune-response-profiles-of-calves-following-vaccination-with-live-bcg-and-inactivated-mycobacterium-bovis-vaccine-candidates
#20
E M D L van der Heijden, J Chileshe, J C M Vernooij, C Gortazar, R A Juste, I Sevilla, J E Crafford, V P M G Rutten, A L Michel
Conventional control and eradication strategies for bovine tuberculosis (BTB) face tremendous difficulties in developing countries; countries with wildlife reservoirs, a complex wildlife-livestock-human interface or a lack of veterinary and veterinary public health surveillance. Vaccination of cattle and other species might in some cases provide the only suitable control strategy for BTB, while in others it may supplement existing test-and-slaughter schemes. However, the use of live BCG has several limitations and the global rise of HIV/AIDS infections has furthermore warranted the exploration of inactivated vaccine preparations...
2017: PloS One
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