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https://www.readbyqxmd.com/read/30025311/association-between-irritability-and-suicide-related-outcomes-across-the-life-course-systematic-review-of-both-community-and-clinical-studies
#1
REVIEW
Massimiliano Orri, Lea C Perret, Gustavo Turecki, Marie-Claude Geoffroy
BACKGROUND: Irritability is gaining considerable attention as a risk factor for suicide-related outcomes (suicide mortality, attempt, and ideation). However, the evidence of this association is scant. We conducted a systematic review of the evidence regarding the associations between irritability and suicide-related outcomes across the life-course. METHODS: We conducted a systematic search on Medline and PsycINFO (up to January 2018) for original articles published in English investigating the association between irritability and suicide-related outcomes...
July 4, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/30025284/the-prevalence-of-diagnosed-obsessive-compulsive-disorder-and-associated-comorbidities-a-population-based-canadian-study
#2
Sydney Osland, Paul D Arnold, Tamara Pringsheim
The objective of this study was to provide epidemiological data regarding obsessive compulsive disorder (OCD) in Canada, and examine related conditions, childhood experiences and healthcare utilization. A Statistics Canada population-based health survey was utilized (N = 25,097). The prevalence of diagnosed OCD in Canada was 0.93% (95% CI 0.75-1.11). People with OCD were younger and more likely to have lower incomes. They were more likely to have mood disorders including depression and bipolar disorder (both diagnosed conditions and by screening), and generalized anxiety disorder...
July 11, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/30025123/systemic-7-8-dihydroxyflavone-treatment-protects-immature-retinas-against-hypoxic-ischemic-injury-via-m%C3%A3-ller-glia-regeneration-and-mapk-erk-activation
#3
Hsiu-Mei Huang, Chao-Ching Huang, Meng-Han Tsai, Yi-Chieh Poon, Ying-Chao Chang
Purpose: Perinatal hypoxic-ischemic (HI) injury causes significant damages in the immature retina. The brain-derived neurotrophic factor is well known for its neuroprotective role but has limited clinical applications. A selective agonist of tyrosine kinase receptor B, 7,8-dihydroxyflavone (DHF), is a powerful therapeutic tool, when administered systemically. However, it remains unclear whether DHF treatment can protect the immature retinas against HI injury. Methods: Postnatal (P) day 7 rat pups were intraperitoneally injected with DHF or vehicle 2 hours before and 18 hours after being subjected to HI injury...
June 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/30024721/mode-selective-raman-imaging-of-dopamine-human-dopamine-transporter-interaction-in-live-cells
#4
Achut Prasad Silwal, H Peter Lu
Dopamine (DA) is the catecholamine neurotransmitter which interacts with dopamine receptors (DARs) to generate dopaminergic signals in nervous system. Dopamine transporter (DAT) interacts with DA to maintain DA's homeostasis in synaptic and perisynaptic space. DAT and DARs have great importance in central nervous system (CNS) since they are associated to the targeted binding of drugs. Interactions of DA, or its analogue with DARs, or DAT have been studied extensively to understand the mechanism of the dopaminergic signaling process and several neurodegenerative diseases including schizophrenia, Parkinson's diseases, addiction, attention deficit hyperactivity disorder (ADHD), and bipolar disorder...
July 19, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/30024639/the-feasibility-and-acceptability-of-a-novel-anxiety-in-bipolar-disorder-intervention-compared-to-treatment-as-usual-a-randomized-controlled-trial
#5
Steven H Jones, Dawn Knowles, Elizabeth Tyler, Fiona Holland, Sarah Peters, Fiona Lobban, Brian Langshaw, Claire Hilton, Rita Long, Kay Gantt, Rebecca Owen, Chris Roberts, Lisa Riste
BACKGROUND: Comorbid anxiety is common in bipolar disorder (BD) and associated with worse clinical outcomes including increased suicidality. Despite effective psychological treatments for anxiety, research into treating anxiety in BD is underdeveloped. This paper describes a novel psychological intervention to address anxiety in context of bipolar disorder (AIBD). METHODS: Adults with BD and clinically significant anxiety symptoms were randomized to AIBD plus treatment as usual (TAU) or TAU alone...
July 19, 2018: Depression and Anxiety
https://www.readbyqxmd.com/read/30024576/amplitude-loss-of-the-high-frequency-flicker-electroretinogram-in-early-diabetic-retinopathy
#6
J Jason McAnany, Jason C Park, Felix Y Chau, Yannek I Leiderman, Jennifer I Lim, Norman P Blair
PURPOSE: To evaluate retinal dysfunction in diabetic patients who have mild or no nonproliferative diabetic retinopathy (DR) using the high-frequency flicker electroretinogram. METHODS: Light-adapted flicker electroretinograms were recorded from 15 diabetic patients who have no clinically apparent retinopathy, 15 diabetic patients who have mild nonproliferative DR, and 15 nondiabetic, age-equivalent controls. Electroretinograms were elicited by full-field flicker at 2 temporal frequencies, 31...
July 16, 2018: Retina
https://www.readbyqxmd.com/read/30024046/experimental-noxious-stimulation-of-the-right-masseter-muscle-does-not-affect-bilateral-masseter-and-temporalis-muscle-activity-and-force-parameters-during-standardized-isometric-biting-tasks
#7
Isbel Sandoval, Polyana Moura Ferreira, Fabian Obregon, Terry Whittle, Greg M Murray
AIM: To determine if the electromyographic (EMG) activity of the left and right masseter and anterior temporalis muscles is altered by experimental right masseter muscle noxious stimulation during goal-directed isometric biting tasks in asymptomatic humans. METHODS: Isometric biting tasks (slow and fast ramp biting tasks, 2-step biting task) were performed on an intraoral force transducer in 18 participants during the following blocks: baseline block, hypertonic saline infusion into the right masseter muscle (painful block), and isotonic saline infusion into the right masseter (control block)...
July 19, 2018: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/30023567/poly-l-lysine-coated-liquid-crystal-droplets-for-sensitive-detection-of-dna-and-their-applications-in-controlled-release-of-drug-molecules
#8
Indu Verma, Sumyra Sidiq, Santanu Kumar Pal
Interactions between DNA and adsorbed poly(l-lysine) (PLL) on liquid crystal (LC) droplets were investigated using polarizing optical microcopy and epi-fluorescence microscopy. Earlier, we demonstrated that adsorption of PLL to the LC/aqueous interface resulted in homeotropic orientation of the LC and thus exhibited a radial configuration of the LC confined within the droplets. Subsequent adsorption of DNA (single-stranded DNA/double-stranded DNA) at PLL-coated LC droplets was found to trigger an LC reorientation within the droplets, leading to preradial/bipolar configuration of those droplets...
November 30, 2017: ACS Omega
https://www.readbyqxmd.com/read/30023451/integrated-psychological-therapy-for-people-with-bipolar-disorder-and-co-morbid-alcohol-use-a-feasibility-and-acceptability-randomised-controlled-trial
#9
Steven Jones, Heather Robinson, Lisa Riste, Chris Roberts, Sarah Peters, Lucy Bateman, Emma Weymouth, Christine Barrowclough
Background: Co-morbid substance misuse, particularly alcohol, is common in bipolar disorder (BD) and associated with worse treatment outcomes. Research into psychological interventions for substance misuse in BD is at an early stage and no studies have specifically targeted problematic alcohol use. This paper describes the context and protocol for a feasibility and acceptability randomised controlled trial (RCT) evaluating a novel intervention combining motivational interviewing and cognitive behavioural therapy (MI-CBT) for participants with BD and problematic alcohol use, developed in collaboration with people with lived experience of both issues...
June 2018: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/30022520/statins-and-cognition-in-late-life-bipolar-disorder
#10
Soham Rej, Sarah Waters Schulte, Tarek K Rajji, Ariel G Gildengers, Dielle Miranda, Mahesh Menon, Meryl A Butters, Benoit H Mulsant
OBJECTIVES: Recent data suggests that statins have positive effects on cognition in older adults. Studies in patients with mood disorders have found contradicting positive and negative effects of statins on mood and cognition, with limited data in bipolar disorder (BD). The objective of this study was to assess the association between statin use and cognition in older adults with BD. METHODS: In a cross-sectional sample of 143 euthymic older adults with BD (age ≥ 50), statin users (n = 48) and nonusers (n = 95) were compared for cognitive outcomes: Global and cognitive domain z-scores were calculated from detailed neuropsychological batteries using normative data from healthy comparators (n = 87)...
July 19, 2018: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/30022319/prevalence-of-seasonal-depression-in-a-prospective-cohort-study
#11
Anna Wirz-Justice, Vladeta Ajdacic, Wulf Rössler, Hans-Christoph Steinhausen, Jules Angst
The prevalence of autumn/winter seasonality in depression has been documented in the longitudinal Zurich cohort study by five comprehensive diagnostic interviews at intervals over more than 20 years (N = 499). Repeated winter major depressive episodes (MDE-unipolar + bipolar) showed a prevalence of 3.44% (5× more women than men), whereas MDE with a single winter episode was much higher (9.96%). A total of 7.52% suffered from autumn/winter seasonality in major and minor depressive mood states. The clinical interviews revealed novel findings: high comorbidity of Social Anxiety Disorder and Agoraphobia within the repeated seasonal MDE group, high incidence of classic diurnal variation of mood (with evening improvement), as well as a high rate of oversensitivity to light, noise, or smell...
July 18, 2018: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/30022042/nitrated-meat-products-are-associated-with-mania-in-humans-and-altered-behavior-and-brain-gene-expression-in-rats
#12
Seva G Khambadkone, Zachary A Cordner, Faith Dickerson, Emily G Severance, Emese Prandovszky, Mikhail Pletnikov, Jianchun Xiao, Ye Li, Gretha J Boersma, C Conover Talbot, Wayne W Campbell, Christian S Wright, C Evan Siple, Timothy H Moran, Kellie L Tamashiro, Robert H Yolken
Mania is a serious neuropsychiatric condition associated with significant morbidity and mortality. Previous studies have suggested that environmental exposures can contribute to mania pathogenesis. We measured dietary exposures in a cohort of individuals with mania and other psychiatric disorders as well as in control individuals without a psychiatric disorder. We found that a history of eating nitrated dry cured meat but not other meat or fish products was strongly and independently associated with current mania (adjusted odds ratio 3...
July 18, 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/30020838/biophysical-basis-of-subthalamic-local-field-potentials-recorded-from-deep-brain-stimulation-electrodes
#13
Nicholas Maling, Scott F Lempka, Zack Blumenfeld, H M Bronte-Stewart, Cameron C McIntyre
Clinical deep brain stimulation (DBS) technology is evolving to enable chronic recording of local field potentials (LFPs) that represent electrophysiological biomarkers of the underlying disease state. However, little is known about the biophysical basis of LFPs, or how the patient's unique brain anatomy and electrode placement impact the recordings. Therefore, we developed a patient-specific computational framework to analyze LFP recordings within a clinical DBS context. We selected a subject with Parkinson's disease implanted with a Medtronic Activa PC+S DBS system and reconstructed their subthalamic nucleus (STN) and DBS electrode location using medical imaging data...
July 18, 2018: Journal of Neurophysiology
https://www.readbyqxmd.com/read/30019743/-treatment-resistant-constipation-and-the-need-for-chronic-use-of-laxatives-following-lithium-administration
#14
J Newell
Just a few days after the introduction of lithium therapy to treat a 35-year old man suffering from a bipolar disorder, complaints of constipation arose. The issue persisted despite numerous trials with first and second line laxatives at adequate dose and duration over a period of several weeks. After the singular administration of highly dosed macrogol laxatives with electrolytes, a lower dosage was established as maintenance treatment, yielding promising results. However, the potential interactions as well as the possible fluctuations in serum lithium levels when combining a maintenance treatment of both lithium and laxatives remains to be evaluated...
2018: Tijdschrift Voor Psychiatrie
https://www.readbyqxmd.com/read/30019742/-the-diagnosis-of-unipolar-versus-bipolar-disorders-using-neuroimaging
#15
M M Rive, H G Ruhé, D J Veltman, A H Schene
Clinical differentiation between unipolar and bipolar depression can be a challenge. Additional diagnostic tools based on biomarkers could help resolve ambiguous cases. In this article we discuss studies from the dissertation 'Bipolar or unipolar? A brain teasing question', investigating to which extent neuroimaging could contribute to such detection.<br /> AIM: To investigate whether neuroimaging can aid in differentiating between uni- and bipolar disorder.<br /> METHOD: An analysis of the brain anatomy and functioning in medication-free uni- and bipolar participants and healthy controls using magnetic resonance imaging (MRI)...
2018: Tijdschrift Voor Psychiatrie
https://www.readbyqxmd.com/read/30019638/involvement-of-heme-oxygenase-1-in-neuropsychiatric-and-neurodegenerative-diseases
#16
Vivian B Neis, Priscila B Rosa, Morgana Moretti, Ana Lucia S Rodrigues
Heme oxygenase (HO) family catalyzes the conversion of heme into free iron, carbon monoxide and biliverdin. It possesses two well characterized isoforms: HO-1 and HO-2. Under brain physiological conditions, the expression of HO-2 is constitutive, abundant and ubiquitous, whereas HO-1 mRNA and protein are restricted to small populations of neurons and neuroglia. HO-1 is an inducible enzyme that has been shown to participate as an essential defensive mechanism for neurons exposed to oxidant challenges, being related to antioxidant defenses in certain neuropathological conditions...
July 17, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/30018414/vitamin-d-folate-and-the-intracranial-volume-in-schizophrenia-and-bipolar-disorder-and-healthy-controls
#17
Tiril P Gurholt, Kåre Osnes, Mari Nerhus, Kjetil N Jørgensen, Vera Lonning, Akiah O Berg, Ole A Andreassen, Ingrid Melle, Ingrid Agartz
Vitamin D and folate deficiency are considered risk factors for schizophrenia and bipolar disorders, but it is unknown how vitamin D and folate influence the growing brain, cranium or the clinical phenotype. Serum vitamin D and folate levels are in part genetically regulated. We investigated whether adult vitamin D and folate levels are associated with the intracranial volume (ICV) under the hypothesis that developmental vitamin D or folate levels influence neurodevelopment and that current levels are associated with ICV...
July 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30018369/role-of-disordered-bipolar-complexions-on-the-sulfur-embrittlement-of-nickel-general-grain-boundaries
#18
Tao Hu, Shengfeng Yang, Naixie Zhou, Yuanyao Zhang, Jian Luo
Minor impurities can cause catastrophic fracture of normally ductile metals. Here, a classic example is represented by the sulfur embrittlement of nickel, whose atomic-level mechanism has puzzled researchers for nearly a century. In this study, coupled aberration-corrected electron microscopy and semi-grand-canonical-ensemble atomistic simulation reveal, unexpectedly, the universal formation of amorphous-like and bilayer-like facets at the same general grain boundaries. Challenging the traditional view, the orientation of the lower-Miller-index grain surface, instead of the misorientation, dictates the interfacial structure...
July 17, 2018: Nature Communications
https://www.readbyqxmd.com/read/30017778/speech-structure-links-the-neural-and-socio-behavioural-correlates-of-psychotic-disorders
#19
Lena Palaniyappan, Natália Bezerra Mota, Shamuz Oowise, Vijender Balain, Mauro Copelli, Sidarta Ribeiro, Peter F Liddle
BACKGROUND: A longstanding notion in the concept of psychosis is the prominence of loosened associative links in thought processes. Assessment of such subtle aspects of thought disorders has proved to be a challenging task in clinical practice and to date no surrogate markers exist that can reliably track the physiological effects of treatments that could reduce thought disorders. Recently, automated speech graph analysis has emerged as a promising means to reliably quantify structural speech disorganization...
July 11, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/30017527/extent-and-magnitude-of-low-voltage-areas-assessed-by-ultra-high-density-electroanatomical-mapping-correlate-with-left-atrial-function
#20
F Hohendanner, I Romero, F Blaschke, F R Heinzel, B Pieske, L-H Boldt, A S Parwani
INTRODUCTION: The extent of left atrial (LA) adverse remodeling as a cardiac disease marker has become increasingly important. In patients with atrial fibrillation (AF), atrial remodeling (AR) is accompanied by increased mortality. The relation between LA function and the extent of low-voltage areas (LVAs) has not yet been systematically investigated. METHODS: In patients with AF undergoing catheter-ablation, LA was studied using echocardiography and ultra-high-density mapping (Rhythmia®)...
July 9, 2018: International Journal of Cardiology
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