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https://www.readbyqxmd.com/read/28340448/structural-correlates-of-creative-thinking-in-patients-with-bipolar-disorder-and-healthy-controls-a-voxel-based-morphometry-study
#1
Pei-Chi Tu, Yi-Hsuan Kuan, Cheng-Ta Li, Tung-Ping Su
BACKGROUND: This study investigated the structural correlates of creative thinking in patients with bipolar disorder (BD) to understand the possible neural mechanism of creative thinking in BD. METHODS: We recruited 59 patients with BD I or BD II (35.3±8.5 y) and 56 age- and sex-matched controls (HCs; 34±7.4 y). Each participant underwent structural magnetic resonance imaging and evaluation of creative thinking, which was assessed using two validated tools: the Chinese version of the Abbreviated Torrance Test for Adults for divergent thinking and the Chinese Word Remote Associates Test for remote association...
March 12, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28340442/neurocognitive-performance-as-an-endophenotype-for-mood-disorder-subgroups
#2
Alison K Merikangas, Lihong Cui, Monica E Calkins, Tyler M Moore, Ruben C Gur, Raquel E Gur, Kathleen R Merikangas
BACKGROUND: There is growing evidence that neurocognitive function may be an endophenotype for mood disorders. The goal of this study is to examine the specificity and familiality of neurocognitive functioning across the full range of mood disorder subgroups, including Bipolar I (BP-I), Bipolar II (BP-II), Major Depressive Disorders (MDD), and controls in a community-based family study. METHODS: A total of 310 participants from 137 families with mood spectrum disorders (n=151) and controls (n=159) completed the University of Pennsylvania's Computerized Neurocognitive Battery (CNB) that assessed the accuracy and speed of task performance across five domains...
March 10, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28340429/simple-index-of-functional-connectivity-at-rest-in-multiple-sclerosis-fatigue
#3
Korhan Buyukturkoglu, Camillo Porcaro, Carlo Cottone, Andrea Cancelli, Matilde Inglese, Franca Tecchio
OBJECTIVE: To investigate the EEG-derived functional connectivity at rest (FCR) patterns of fatigued Multiple Sclerosis (MS) patients in order to find good parameters for a future EEG-Neurofeedback intervention to reduce their fatigue symptoms. METHODS: We evaluated FCR between hemispheric homologous areas, via spectral coherence between pairs of corresponding left and right bipolar derivations, in the Theta, Alpha and Beta bands. We estimated FCR in 18MS patients with different levels of fatigue and minimal clinical severity and in 11 age and gender matched healthy controls...
February 28, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28340110/peri-mitral-atrial-flutter-personalized-ablation-strategy-based-on-arrhythmogenic-substrate
#4
Jinbo Yu, Kai Chen, Bing Yang, Fengxiang Zhang, Weizhu Ju, Hongwu Chen, Gang Yang, Mingfang Li, Benqi Wang, Kai Gu, Feifan Ouyang, Siew Yen Ho, Sunny Po, Minglong Chen
Aims: The aim of this study is to characterize the arrhythmogenic substrate for peri-mitral atrial flutter (PMAFL), thereby determining a personalized ablation strategy to treat PMAFL. Methods and results: Thirty-six consecutive PMAFL patients (mean age: 63.8 ± 11.3, 23 males) underwent detailed three-dimensional electroanatomic mapping in left atrium (LA). The LA was divided into septal-anterior wall (SAW), posterior inferior wall (PIW), and mitral isthmus (MI) region, respectively...
March 1, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28339618/telomere-length-oxidative-stress-inflammation-and-bdnf-levels-in-siblings-of-patients-with-bipolar-disorder-implications-for-accelerated-cellular-aging
#5
Mirela Paiva Vasconcelos-Moreno, Gabriel Rodrigo Fries, Carolina Gubert, Bárbara Tietböhl Martins Quadros Dos Santos, Adam Fijtman, Juliana Sartori, Pamela Ferrari, Lucas Kich Grun, Mariana Migliorini Parisi, Fátima Theresinha Costa Rodrigues Guma, Florencia Maria Barbé-Tuana, Flávio Kapczinski, Adriane Ribeiro Rosa, Lakshmi N Yatham, Marcia Kauer-Sant'Anna
Background: Growing evidence supports the existence of neurobiological trait abnormalities in individuals at genetic risk for bipolar disorder. The aim of this study was to examine potential differences in brain-derived neurotrophic factor, cytokines, oxidative stress, and telomere length markers between patients with bipolar disorder, their siblings, and healthy controls. Methods: Thirty-six patients with bipolar disorder type I, 39 siblings, and 44 healthy controls were assessed...
January 30, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28339432/bipolar-versus-unipolar-intraarticular-pulsed-radiofrequency-thermocoagulation-in-chronic-knee-pain-treatment-a-prospective-randomized-trial
#6
Ersel Gulec, Hayri Ozbek, Sinan Pektas, Geylan Isik
BACKGROUND: Chronic knee pain is a major widespread problem causing significant impairment of daily function. Pulsed radiofrequency has been shown to reduce severe chronic joint pain as a non-pharmacological and less invasive treatment method. OBJECTIVE: We aimed to compare the effectiveness of unipolar and bipolar intraarticular pulsed radiofrequency methods in chronic knee pain control. STUDY DESIGN: Prospective, randomized, double-blind study...
March 2017: Pain Physician
https://www.readbyqxmd.com/read/28339282/melatonin-for-reducing-weight-gain-following-administration-of-atypical-antipsychotic-olanzapine-for-adolescents-with-bipolar-disorder-a-randomized-double-blind-placebo-controlled-trial
#7
Seyed-Ali Mostafavi, Mahmoud Solhi, Mohammad-Reza Mohammadi, Shahin Akhondzadeh
OBJECTIVES: We aimed to evaluate melatonin effectiveness in weight gain reduction following olanzapine use for 11-17-year-old bipolar disorder patients. EXPERIMENTAL DESIGN: Seventy-seven adolescent outpatients, subsequent to their initial diagnosis of bipolar I disorder by a psychiatrist, entered this study. After assessing inclusion and exclusion criteria, 48 patients consented to participate. Twenty-four patients were allocated to receive olanzapine, lithium carbonate, and melatonin, and 24 patients were allocated to receive olanzapine, lithium carbonate, and placebo by simple randomization...
March 24, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28335531/associations-among-substance-use-mental-health-disorders-and-self-harm-in-a-prison-population-examining-group-risk-for-suicide-attempt
#8
Madison L Gates, Asher Turney, Elizabeth Ferguson, Veronica Walker, Michelle Staples-Horne
Substance use disorders (SUD) and mental health disorders are significant public health issues that co-occur and are associated with high risk for suicide attempts. SUD and mental health disorders are more prevalent among offenders (i.e., prisoners or inmates) than the non-imprisoned population, raising concerns about the risk of self-harm. This cross-sectional study examined the population of a state prison system (10,988 out of 13,079) to identify associations among SUD (alcohol, cannabis, intravenous drugs, narcotics, and tobacco smoking), mental health disorders (anxiety, bipolar, depression, and psychotic disorders), and suicide attempts...
March 20, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28334950/downstream-targets-of-gwas-detected-genes-for-breast-lung-and-prostate-and-colon-cancer-converge-to-g1-s-transition-pathway
#9
Olga Y Gorlova, Eugene I Demidenko, Christopher I Amos, Ivan P Gorlov
Genome-wide association studies (GWASs) identified over 500 single nucleotide polymorphisms (SNPs) influencing cancer risk. It is logical to expect the cancer-associated genes to cluster in pathways directly involved in carcinogenesis, e.g. cell cycle. Nevertheless, analyses of the GWAS-detected cancer risk genes usually show no or weak enrichment by known cancer genes.We hypothesized that GWAS-detected cancer risk-associated genes function as upstream regulators of the genes directly involved in carcinogenesis...
March 1, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28334676/manual-motor-speed-dysfunction-as-a-neurocognitive-endophenotype-in-euthymic-bipolar-disorder-patients-and-their-healthy-relatives-evidence-from-a-5-year-follow-up-study
#10
P Correa-Ghisays, V Balanzá-Martínez, G Selva-Vera, J Vila-Francés, E Soria-Olivas, J Vivas-Lalinde, C San Martín, A M Borrás, R Ayesa-Arriola, J Sanchez-Moreno, J Sánchez-Ort, B Crespo-Facorro, E Vieta, R Tabarés-Seisdedos
BACKGROUND: Few studies have examined Manual Motor Speed (MMS) in bipolar disorder (BD). The aim of this longitudinal, family study was to explore whether dysfunctional MMS represents a neurocognitive endophenotype of BD. METHODS: A sample of 291 subjects, including 131 BD patients, 77 healthy first-degree relatives (BD-Rel), and 83 genetically-unrelated healthy controls (HC), was assessed with the Finger-Tapping Test (FTT) on three occasions over a 5-year period...
March 16, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28334448/carotid-artery-bursting-pressure-and-seal-time-after-multiple-uses-of-a-vessel-sealing-device
#11
Jocelin S Blake, Brian J Trumpatori, Kyle G Mathews, Emily H Griffith
OBJECTIVE: To determine any loss of function of a single-use bipolar vessel sealing device after repeated sterilization and use on canine carotid arteries. STUDY DESIGN: Ex vivo; randomized block design (dog). SAMPLE POPULATION: Carotid artery segments (n = 90) from 15 canine cadavers. METHODS: Six 10-mm LigaSure Atlas 20 cm devices (Covidien Inc, Minneapolis, Minnesota) were used to seal canine carotid artery segments in one cadaver, then resterilized using ethylene oxide and reused in a second cadaver, and so on, for a total of 15 uses/15 cadavers per LigaSure...
March 23, 2017: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/28334377/lrit3-differentially-affects-connectivity-and-synaptic-transmission-of-cones-to-on-and-off-bipolar-cells
#12
Marion Neuillé, Yan Cao, Romain Caplette, Debbie Guerrero-Given, Connon Thomas, Naomi Kamasawa, José-Alain Sahel, Christian P Hamel, Isabelle Audo, Serge Picaud, Kirill A Martemyanov, Christina Zeitz
Purpose: Mutations in LRIT3 lead to complete congenital stationary night blindness (cCSNB). Using a cCSNB mouse model lacking Lrit3 (nob6), we recently have shown that LRIT3 has a role in the correct localization of TRPM1 (transient receptor potential melastatin 1) to the dendritic tips of ON-bipolar cells (BCs), contacting both rod and cone photoreceptors. Furthermore, postsynaptic clustering of other mGluR6 cascade components is selectively eliminated at the dendritic tips of cone ON-BCs...
March 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28334111/g%C3%AE-2-regulates-the-multipolar-bipolar-transition-of-newborn-neurons-in-the-developing-neocortex
#13
Ye Guo, Xiaoxiao He, Lu Zhao, Lin Liu, Huifang Song, Xudong Wang, Jiahui Xu, Xingda Ju, Weixiang Guo, Xiaojuan Zhu
Proper neuronal migration is critical for the formation of the six-layered neocortex in the mammalian brain. However, the precise control of neuronal migration is not well understood. Heterotrimeric guanine nucleotide binding proteins (G proteins), composed of Gα and Gβγ, transduce signals from G protein-coupled receptors to downstream effectors and play crucial roles in brain development. However, the functions of individual subunits of G proteins in prenatal brain development remain unclear. Here, we report that Gβ2 is expressed in the embryonic neocortex, with abundant expression in the intermediate zone, and is significantly upregulated in differentiated neurons...
February 23, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28332227/general-features-of-inhibition-in-the-inner-retina
#14
Katrin Franke, Tom Baden
Visual processing starts in the retina. Within only two synaptic layers, a large number of parallel information channels emerge, each encoding a highly processed feature like edges or the direction of motion. Much of this functional diversity arises in the inner plexiform layer, where inhibitory amacrine cells modulate the excitatory signal of bipolar and ganglion cells. Studies investigating individual amacrine cell circuits like the starburst or A17 circuit have demonstrated that single types can possess specific morphological and functional adaptations to convey a particular function in one or a small number of inner retinal circuits...
March 23, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28332124/use-of-physical-restraints-among-patients-with-bipolar-disorder-in-ethiopian-mental-specialized-hospital-outpatient-department-cross-sectional-study
#15
Habte Belete
BACKGROUND: Even though United Nation announced that all persons with a mental illness shall be treated with humanity and respect for the inherent dignity of the human being, up to now, the use of coercion (physical restrain) is still considered as unavoidable in managing abnormal behavior of psychiatric patients. But, there is no information regarding the magnitude and contributing factors of physical restrain among bipolar patients in low-income countries like Ethiopia. METHODS: A cross-sectional study was conducted at Amanuel Mental Specialized Hospital from May 1 to June 1, 2015 among 400 participants who were selected by systematic random sampling technique...
December 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/28332123/self-poisoning-suicide-deaths-in-people-with-bipolar-disorder-characterizing-a-subgroup-and-identifying-treatment-patterns
#16
Ayal Schaffer, Lauren M Weinstock, Mark Sinyor, Catherine Reis, Benjamin I Goldstein, Lakshmi N Yatham, Anthony J Levitt
OBJECTIVE: To characterize self-poisoning suicide deaths in BD compared to other suicide decedents. METHODS: Extracted coroner data from all suicide deaths (n = 3319) in Toronto, Canada from 1998 to 2012. Analyses of demographics, clinical history, recent stressors, and suicide details were conducted in 5 subgroups of suicide decedents: BD self-poisoning, BD other methods, non-BD self-poisoning, non-BD other methods, and unipolar depression self-poisoning. Toxicology results for lethal and present substances were also compared between BD and non-BD self-poisoning subgroups as well as between BD and unipolar depression self-poisoning subgroups...
December 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/28332122/cognitive-impairments-and-predominant-polarity-in-bipolar-disorder-a-cross-sectional-study
#17
Gabriel Okawa Belizario, Alexandre Duarte Gigante, Cristiana Castanho de Almeida Rocca, Beny Lafer
BACKGROUND: Bipolar disorder (BD) patients exhibit cognitive impairments during euthymic states. Studies suggest that manic episodes may be correlated to cognitive impairments. The present study investigated the relationship between predominant polarity and the cognitive deficits frequently detected in bipolar patients. We hypothesize that mania predominant polarity (MPP) patients should exhibit greater cognitive impairments in comparison to depressive (DPP) and indefinite predominant polarity (IPP) patients and healthy control (HC) individuals...
December 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/28332121/impairment-in-emotion-perception-from-body-movements-in-individuals-with-bipolar-i-and-bipolar-ii-disorder-is-associated-with-functional-capacity
#18
Anja Vaskinn, Trine Vik Lagerberg, Thomas D Bjella, Carmen Simonsen, Ole A Andreassen, Torill Ueland, Kjetil Sundet
BACKGROUND: Individuals with bipolar disorder present with moderate impairments in social cognition during the euthymic state. The impairment extends to theory of mind and to the perception of emotion in faces and voices, but it is unclear if emotion perception from body movements is affected. The main aim of this study was to examine if participants with bipolar disorder perform worse than healthy control participants on a task using point-light displays of human full figures moving in a manner indicative of a basic emotion (angry, happy, sad, fearful, neutral/no emotion)...
December 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/28331326/lithium-in-late-life-mania-a-systematic-review
#19
REVIEW
Pasquale De Fazio, Raffaele Gaetano, Mariarita Caroleo, Maria Pavia, Giovanbattista De Sarro, Andrea Fagiolini, Cristina Segura-Garcia
The prevalence of mania among >65-year-olds ranges from 0.1% to 0.4% and its treatment is a particular challenge for clinicians. Although lithium is the treatment of choice for bipolar disorder (BD), its use in elderly population was recently questioned. This study provides a comprehensive review of literature on the efficacy and tolerability of lithium as a pharmacologic treatment for mania in elderly BD patients. We conducted a systematic review, based on PRISMA guidelines, of articles published between 1970 and August 2016 and indexed in the following databases: EMBASE, MEDLINE, Cochrane Library Databases and PsycINFO...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28331323/bipolar-disorder-recurrence-prevention-using-self-monitoring-daily-mood-charts-case-reports-from-a-5-year-period
#20
Norio Yasui-Furukori, Kazuhiko Nakamura
Mood symptoms in bipolar disorders are significantly related to psychosocial events, and the personalized identification of symptom triggers is important. Ecological momentary assessments have been used in paper-and-pencil form to explore emotional reactivity to daily life stress in patients with bipolar disorder. However, there are few data on long-term recurrence prevention effects using ecological momentary assessments. Subjects were three outpatients with bipolar disorder who had a history of at least one admission...
2017: Neuropsychiatric Disease and Treatment
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