Arnau Ramos-Prats, Pawel Matulewicz, Marie-Luise Edenhofer, Kai-Yi Wang, Chia-Wei Yeh, Ana Fajardo-Serrano, Michaela Kress, Kai Kummer, Cheng-Chang Lien, Francesco Ferraguti
Subtype 5 metabotropic glutamate receptors (mGlu5 ) are known to play an important role in regulating cognitive, social and valence systems. However, it remains largely unknown at which circuits and neuronal types mGlu5 act to influence these behavioral domains. Altered tissue- or cell-specific expression or function of mGlu5 has been proposed to contribute to the exacerbation of neuropsychiatric disorders. Here, we examined how these receptors regulate the activity of somatostatin-expressing (SST+) neurons, as well as their influence on behavior and brain rhythmic activity...
April 4, 2024: Molecular Psychiatry